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Conserved domains on  [gi|760031442|ref|WP_043714418|]
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two-component system regulatory protein YycI [Symbiobacterium thermophilum]

Protein Classification

two-component system regulatory protein YycI( domain architecture ID 10008884)

two-component system regulatory protein YycI is a membrane-anchored periplasmic protein that, together with YycH, regulates the activity of the two-component system WalR/WalK (also called YycFG), which regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance, and antibiotic resistance

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YycI COG4853
YycI protein, regulator of the WalKR two-component signal transduction system [Signal ...
1-284 4.73e-50

YycI protein, regulator of the WalKR two-component signal transduction system [Signal transduction mechanisms];


:

Pssm-ID: 443881  Cd Length: 259  Bit Score: 165.87  E-value: 4.73e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442   1 MDWTRARAILIAAFTVVNLILAYSLWGPKGELDPGEPtarSQLVQLRTRLDERGLILPNavTLPTTPHPMRFLRVEFRpN 80
Cdd:COG4853    1 MDWSKIKTIFIIVFLILNIFLLFQLIEKQQENQVLSS---LSETTIEERLKADNITLKT--DLPKETPPGSYLSAKFK-D 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442  81 PTKAPpvdepsegapaASRLRSRYDAAARETVLEpvdGAGGTPVDLSDRLLLRQvAEDFLRANGLFPHDVQLSGIflREN 160
Cdd:COG4853   75 FTEAE-----------LEQLKGQKVKISDNTKLY---STLKEPIKISDKDDLED-LEDFVKSNVLFGKEYQYWKY--DSD 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442 161 GAMVEFVPTYDGLPVF---SGYLRVYLSPQG-VERVAHHWVEPVGfKPGAPKAVRAASEALLRLA--GHLEPGDgqvrTI 234
Cdd:COG4853  138 GNTIVFFQTYDGRPIYynqNAQLTFYLNDDNeITSYTQTYLDDIE-ELGEKKDLISAIKAIETLYenNELPSNS----TI 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 760031442 235 VDVRLGYYSgpsvTVPgaeEISAWETVPVWRITLDNG---QVYYVNAFNGELE 284
Cdd:COG4853  213 TDIKLGYYS----LVQ---LSDTQVLAPTWRITVENEdgtEIYFVNAITGEII 258
 
Name Accession Description Interval E-value
YycI COG4853
YycI protein, regulator of the WalKR two-component signal transduction system [Signal ...
1-284 4.73e-50

YycI protein, regulator of the WalKR two-component signal transduction system [Signal transduction mechanisms];


Pssm-ID: 443881  Cd Length: 259  Bit Score: 165.87  E-value: 4.73e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442   1 MDWTRARAILIAAFTVVNLILAYSLWGPKGELDPGEPtarSQLVQLRTRLDERGLILPNavTLPTTPHPMRFLRVEFRpN 80
Cdd:COG4853    1 MDWSKIKTIFIIVFLILNIFLLFQLIEKQQENQVLSS---LSETTIEERLKADNITLKT--DLPKETPPGSYLSAKFK-D 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442  81 PTKAPpvdepsegapaASRLRSRYDAAARETVLEpvdGAGGTPVDLSDRLLLRQvAEDFLRANGLFPHDVQLSGIflREN 160
Cdd:COG4853   75 FTEAE-----------LEQLKGQKVKISDNTKLY---STLKEPIKISDKDDLED-LEDFVKSNVLFGKEYQYWKY--DSD 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442 161 GAMVEFVPTYDGLPVF---SGYLRVYLSPQG-VERVAHHWVEPVGfKPGAPKAVRAASEALLRLA--GHLEPGDgqvrTI 234
Cdd:COG4853  138 GNTIVFFQTYDGRPIYynqNAQLTFYLNDDNeITSYTQTYLDDIE-ELGEKKDLISAIKAIETLYenNELPSNS----TI 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 760031442 235 VDVRLGYYSgpsvTVPgaeEISAWETVPVWRITLDNG---QVYYVNAFNGELE 284
Cdd:COG4853  213 TDIKLGYYS----LVQ---LSDTQVLAPTWRITVENEdgtEIYFVNAITGEII 258
YycI pfam09648
YycI protein; This domain is exclusively found in YycI proteins in the low GC content Gram ...
122-279 1.26e-09

YycI protein; This domain is exclusively found in YycI proteins in the low GC content Gram positive species. These two domains share the same structural fold with domains two and three of YycH pfam07435. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localized to the periplasmic space as shown by PhoA fusion studies.


Pssm-ID: 430732  Cd Length: 231  Bit Score: 56.97  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442  122 TPVDLSDRLLLRQVaEDFLRANGLFPH--DVQLSGIFlrENGAMVEFVPTYDGLPVFS--GYLRVYLSP----QGVERVA 193
Cdd:pfam09648  75 KPIKISKDDNLKDL-NDFLNDKKNVLKgkDYQYWKEL--SSKKTIVYFQKYKGKPIYDndAQLVFYLNNdneiTSYTQTY 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442  194 HHWVEPVGFKpgapKAVRAASEALLRLAGHLEPGDGQvrTIVDVRLGYYSgpsvtVPGAEEISAWETVPVWRITLDNG-- 271
Cdd:pfam09648 152 LEDIKELREK----KELISARRAIETLYTNNELKNNS--KVTWIKLGYYS-----LLQQTVRSKQVYVPTWRITIENKss 220
                         170
                  ....*....|.
gi 760031442  272 ---QVYYVNAF 279
Cdd:pfam09648 221 kevQIYFVNAF 231
 
Name Accession Description Interval E-value
YycI COG4853
YycI protein, regulator of the WalKR two-component signal transduction system [Signal ...
1-284 4.73e-50

YycI protein, regulator of the WalKR two-component signal transduction system [Signal transduction mechanisms];


Pssm-ID: 443881  Cd Length: 259  Bit Score: 165.87  E-value: 4.73e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442   1 MDWTRARAILIAAFTVVNLILAYSLWGPKGELDPGEPtarSQLVQLRTRLDERGLILPNavTLPTTPHPMRFLRVEFRpN 80
Cdd:COG4853    1 MDWSKIKTIFIIVFLILNIFLLFQLIEKQQENQVLSS---LSETTIEERLKADNITLKT--DLPKETPPGSYLSAKFK-D 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442  81 PTKAPpvdepsegapaASRLRSRYDAAARETVLEpvdGAGGTPVDLSDRLLLRQvAEDFLRANGLFPHDVQLSGIflREN 160
Cdd:COG4853   75 FTEAE-----------LEQLKGQKVKISDNTKLY---STLKEPIKISDKDDLED-LEDFVKSNVLFGKEYQYWKY--DSD 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442 161 GAMVEFVPTYDGLPVF---SGYLRVYLSPQG-VERVAHHWVEPVGfKPGAPKAVRAASEALLRLA--GHLEPGDgqvrTI 234
Cdd:COG4853  138 GNTIVFFQTYDGRPIYynqNAQLTFYLNDDNeITSYTQTYLDDIE-ELGEKKDLISAIKAIETLYenNELPSNS----TI 212
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 760031442 235 VDVRLGYYSgpsvTVPgaeEISAWETVPVWRITLDNG---QVYYVNAFNGELE 284
Cdd:COG4853  213 TDIKLGYYS----LVQ---LSDTQVLAPTWRITVENEdgtEIYFVNAITGEII 258
YycI pfam09648
YycI protein; This domain is exclusively found in YycI proteins in the low GC content Gram ...
122-279 1.26e-09

YycI protein; This domain is exclusively found in YycI proteins in the low GC content Gram positive species. These two domains share the same structural fold with domains two and three of YycH pfam07435. Both, YycH and YycI are always found in pair on the chromosome, downstream of the essential histidine kinase YycG. Additionally, both proteins share a function in regulating the YycG kinase with which they appear to form a ternary complex. Lastly, the two proteins always contain an N-terminal transmembrane helix and are localized to the periplasmic space as shown by PhoA fusion studies.


Pssm-ID: 430732  Cd Length: 231  Bit Score: 56.97  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442  122 TPVDLSDRLLLRQVaEDFLRANGLFPH--DVQLSGIFlrENGAMVEFVPTYDGLPVFS--GYLRVYLSP----QGVERVA 193
Cdd:pfam09648  75 KPIKISKDDNLKDL-NDFLNDKKNVLKgkDYQYWKEL--SSKKTIVYFQKYKGKPIYDndAQLVFYLNNdneiTSYTQTY 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 760031442  194 HHWVEPVGFKpgapKAVRAASEALLRLAGHLEPGDGQvrTIVDVRLGYYSgpsvtVPGAEEISAWETVPVWRITLDNG-- 271
Cdd:pfam09648 152 LEDIKELREK----KELISARRAIETLYTNNELKNNS--KVTWIKLGYYS-----LLQQTVRSKQVYVPTWRITIENKss 220
                         170
                  ....*....|.
gi 760031442  272 ---QVYYVNAF 279
Cdd:pfam09648 221 kevQIYFVNAF 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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