NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|757782660|ref|WP_043001244|]
View 

MULTISPECIES: MFS transporter [Citrobacter]

Protein Classification

MFS transporter( domain architecture ID 11487773)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
5-410 0e+00

MdfA family multidrug efflux MFS transporter;


:

Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 668.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660   5 LQQGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPV 84
Cdd:PRK15402   1 LSPLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  85 MLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAW 164
Cdd:PRK15402  81 MLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 165 VHVLPWEGMFVLFAALAAIAFFGLQRAMPETATRIGEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPI 244
Cdd:PRK15402 161 IHVLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 245 IIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGWPIVLGLLIAAAATVVSSHAYLWMTAGLSVYA 324
Cdd:PRK15402 241 ILISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 325 FGIGVANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIELSKHAYLLGGNGLFSLFNLASGMLWLLLMFIFLKDKQA 404
Cdd:PRK15402 321 FGIGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPM 400


                 ....*.
gi 757782660 405 GNTREG 410
Cdd:PRK15402 401 GNAHEG 406
 
Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
5-410 0e+00

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 668.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660   5 LQQGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPV 84
Cdd:PRK15402   1 LSPLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  85 MLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAW 164
Cdd:PRK15402  81 MLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 165 VHVLPWEGMFVLFAALAAIAFFGLQRAMPETATRIGEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPI 244
Cdd:PRK15402 161 IHVLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 245 IIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGWPIVLGLLIAAAATVVSSHAYLWMTAGLSVYA 324
Cdd:PRK15402 241 ILISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 325 FGIGVANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIELSKHAYLLGGNGLFSLFNLASGMLWLLLMFIFLKDKQA 404
Cdd:PRK15402 321 FGIGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPM 400


                 ....*.
gi 757782660 405 GNTREG 410
Cdd:PRK15402 401 GNAHEG 406
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 19-398 3.03e-78

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 246.72  E-value: 3.03e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  19 PLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLA 98
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  99 TLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFA 178
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 179 ALAAIAFFGLQRAMPETATRIGEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYG 258
Cdd:cd17320  161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 259 LLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGWPIVLGLLIAAAATVVSSHAYLWMTAGLSVYAFGIGVANAGLVRLT 338
Cdd:cd17320  241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 339 LFASDMSKGTVSAAMGMLQMLIFTVGIELSKHAYlLGGNGLFSLFNLASGMLWLLLMFIF 398
Cdd:cd17320  321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLP-NGTALPMGLLILVLGLLALLLLILL 379
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 32-369 3.75e-27

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 111.32  E-value: 3.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660   32 GNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLL 111
Cdd:TIGR00710  20 GIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  112 RFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGLQRA 191
Cdd:TIGR00710 100 RFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  192 MPETATRIGEPLSLKALGNdYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAG 271
Cdd:TIGR00710 180 LPETLPYEARIQISTYFET-FLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFG 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  272 NLMLARLTARRTVRSLIIMGGWPIVLGLLIAAAATVVSSHAYLWMTAGLSVYAFGIGVANAGLVRLTLFASDMSKGTVSA 351
Cdd:TIGR00710 259 GFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASA 338

                         330
                  ....*....|....*....
gi 757782660  352 AMGMLQM-LIFTVGIELSK 369
Cdd:TIGR00710 339 LFGTLRLvLGAIVGYLVSL 357
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-359 4.56e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.45  E-value: 4.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  13 RQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWF 92
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  93 IVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEG 172
Cdd:COG2814   86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 173 MFVLFAALAAIAFFGLQRAMPETatrigEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQL 252
Cdd:COG2814  166 VFLVNAVLALLALLLLLRLLPES-----RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 253 SSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGgwpivLGLLIAAAATVVSSHAYLWMTAGLSVYAFGIGVANA 332
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG-----LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315

                        330       340
                 ....*....|....*....|....*...
gi 757782660 333 GLVRLTL-FASDMSKGTVSAAMGMLQML 359
Cdd:COG2814  316 LLQALVAeLAPPEARGRASGLYNSAFFL 343
MFS_1 pfam07690
Major Facilitator Superfamily;
58-364 1.79e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.91  E-value: 1.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660   58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  138 VCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGLQRAMPETATRIGEPLSLKALGNDYRLVLK 217
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  218 NGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGwpIVL 297
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL--LLL 275

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 757782660  298 GLLIAAAATVVSSHAYLWMTAGLSVYAFGIGVANAGLVRLTLFASDMSK-GTVSAAMGMLQMLIFTVG 364
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEErGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
5-410 0e+00

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 668.57  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660   5 LQQGARLGRQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPV 84
Cdd:PRK15402   1 LSPLARLGRQALLFPLCLVLFEFATYIANDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  85 MLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAW 164
Cdd:PRK15402  81 MLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 165 VHVLPWEGMFVLFAALAAIAFFGLQRAMPETATRIGEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPI 244
Cdd:PRK15402 161 IHVLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRDYKLVLKNRRFVAGALALGLVSLPLLAWIALSPV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 245 IIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGWPIVLGLLIAAAATVVSSHAYLWMTAGLSVYA 324
Cdd:PRK15402 241 ILISGEQLSSYEYGLLQVPVFGALIAGNLTLARLTSRRPLRSLIRMGLWPMVAGLLLAALATVISSHAYLWLTAGLSLYA 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 325 FGIGVANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIELSKHAYLLGGNGLFSLFNLASGMLWLLLMFIFLKDKQA 404
Cdd:PRK15402 321 FGIGLANAGLYRLTLFSSDVSKGTVSAAMGMLSMLIFTVGIELSKHAYLGGGNGLFNLFNLANGLLWLLLVRIFLKDKPM 400


                 ....*.
gi 757782660 405 GNTREG 410
Cdd:PRK15402 401 GNAHEG 406
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
1-403 1.96e-103

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 312.53  E-value: 1.96e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660   1 MQNRLQQGARLGRqALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIG 80
Cdd:PRK15403   1 MQRMPRFFARHAA-TLFFPMALILYDFAAYLTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  81 RRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLV 160
Cdd:PRK15403  80 RRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 161 GAAWVHVLPWEGMFVLFAALAAIAFFGLQRAMPETATRIGEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIA 240
Cdd:PRK15403 160 GAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPFSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 241 QSPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTvRSLIIMGGWPIVL-GLLIAAAATVVSSHAYLWMTAG 319
Cdd:PRK15403 240 VSPVILIDAGGMTTSQFAWTQVPVFGAVIVANAIVARFVKDPT-EPRFIWRAVPIQLvGLALLIVGNLLWPHVWLWSVLG 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 320 LSVYAFGIGVANAGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGIELSKHAYLLGGNGLFSLFNLASGMLWLLLMFIFL 399
Cdd:PRK15403 319 TSLYAFGIGLIFPTLFRFTLFSNNLPKGTVSASLNMVILMVMAVSVEIGRWLWFNGGRLPFHLLAVVAGVIVVFTLAGLL 398


                 ....
gi 757782660 400 KDKQ 403
Cdd:PRK15403 399 NRVR 402
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 19-398 3.03e-78

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 246.72  E-value: 3.03e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  19 PLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLA 98
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  99 TLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFA 178
Cdd:cd17320   81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 179 ALAAIAFFGLQRAMPETATRIGEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYG 258
Cdd:cd17320  161 LLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 259 LLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGWPIVLGLLIAAAATVVSSHAYLWMTAGLSVYAFGIGVANAGLVRLT 338
Cdd:cd17320  241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 339 LFASDMSKGTVSAAMGMLQMLIFTVGIELSKHAYlLGGNGLFSLFNLASGMLWLLLMFIF 398
Cdd:cd17320  321 LEPFPHVAGTASALLGFLQFLIGALAGALVGLLP-NGTALPMGLLILVLGLLALLLLILL 379
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 32-369 3.75e-27

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 111.32  E-value: 3.75e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660   32 GNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLL 111
Cdd:TIGR00710  20 GIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  112 RFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGLQRA 191
Cdd:TIGR00710 100 RFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  192 MPETATRIGEPLSLKALGNdYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAG 271
Cdd:TIGR00710 180 LPETLPYEARIQISTYFET-FLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFG 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  272 NLMLARLTARRTVRSLIIMGGWPIVLGLLIAAAATVVSSHAYLWMTAGLSVYAFGIGVANAGLVRLTLFASDMSKGTVSA 351
Cdd:TIGR00710 259 GFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASA 338

                         330
                  ....*....|....*....
gi 757782660  352 AMGMLQM-LIFTVGIELSK 369
Cdd:TIGR00710 339 LFGTLRLvLGAIVGYLVSL 357
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
13-359 4.56e-27

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 110.45  E-value: 4.56e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  13 RQALLFPLCLVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWF 92
Cdd:COG2814    6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  93 IVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEG 172
Cdd:COG2814   86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 173 MFVLFAALAAIAFFGLQRAMPETatrigEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQL 252
Cdd:COG2814  166 VFLVNAVLALLALLLLLRLLPES-----RPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 253 SSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGgwpivLGLLIAAAATVVSSHAYLWMTAGLSVYAFGIGVANA 332
Cdd:COG2814  241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIG-----LLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFP 315

                        330       340
                 ....*....|....*....|....*...
gi 757782660 333 GLVRLTL-FASDMSKGTVSAAMGMLQML 359
Cdd:COG2814  316 LLQALVAeLAPPEARGRASGLYNSAFFL 343
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 22-399 2.81e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 94.42  E-value: 2.81e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  22 LVLYEFSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLL 101
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 102 AQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWV--HVLPWEGMFVLFAA 179
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 180 LAAIAFFGLQRAMPET---ATRIGEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYE 256
Cdd:cd06174  161 LALLAAILLLLVVPDPpesARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 257 YGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGwpiVLGLLIAAAATVVSSHAYLWMTAGLSVYAFGIGVANAGLVR 336
Cdd:cd06174  241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIG---LLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757782660 337 LTLFASDMSKGTVSAAMGMLQMLIFTVGIELSkhAYLLGGNGLFSLFNLASGMLWLLLMFIFL 399
Cdd:cd06174  318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLLA--GFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 32-399 1.82e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 83.39  E-value: 1.82e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  32 GNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLL 111
Cdd:cd17474   14 GVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 112 RFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVlPWEGMFVLFAALAAIAFFGLQRA 191
Cdd:cd17474   94 RALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPVAFLAILFL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 192 MPETATRigEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAG 271
Cdd:cd17474  173 LPEPKEK--AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALG 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 272 NLMLARLTARRtvrsliIMGGWPIVLGLLIAAAATVV--SSHAYLWMTAGLSVYAFGIGVANAGL-VRLTLFASDMSKGT 348
Cdd:cd17474  251 SLFVGRLLKKR------FGARRILVIGLLLYALSLLLlgFVPSLALLLIAIVLFGLGLGLNLPLLtTLVTELAPEEERGT 324

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 757782660 349 VSAAMGMLQMLIFTVGIELSkhAYLLGGNGLFSLFNLASGMLWLLLMFIFL 399
Cdd:cd17474  325 ASSLYNFVRFLGQAVGPLLF--GLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
30-245 1.75e-16

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 80.71  E-value: 1.75e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  30 YIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFT 109
Cdd:PRK11043  19 FLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 110 LLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITA-LMANVALiAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGL 188
Cdd:PRK11043  99 VLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFAtIMPLVAL-SPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPT 177

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 757782660 189 QRAMPETATRIGEPLSLkalgnDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPII 245
Cdd:PRK11043 178 LRLKPSKKARKQSQDAL-----TFKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFI 229
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
34-174 1.11e-15

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 78.03  E-value: 1.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  34 DMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRF 113
Cdd:PRK11102   8 DMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRF 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757782660 114 LQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMF 174
Cdd:PRK11102  88 LHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIF 148
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 27-303 2.84e-15

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 75.62  E-value: 2.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  27 FSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIE 106
Cdd:COG0477   24 FLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPE 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFF 186
Cdd:COG0477  104 LLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALV 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 187 gLQRAMPETATRIGEPLSLKALGndyrLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFG 266
Cdd:COG0477  184 -LRLRLPESRGLLLALLALALAA----LLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLL 258

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 757782660 267 ALIAGNLMLARLTARRTVRSLIIMGGWPIVLGLLIAA 303
Cdd:COG0477  259 LAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 27-399 1.35e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 71.45  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  27 FSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIE 106
Cdd:cd17325    6 FLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFF 186
Cdd:cd17325   86 QLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 187 GLQRAMPETA-TRIGEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIF 265
Cdd:cd17325  166 LALLLLPEPRpPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 266 GALIAGNLMLARLTARRTVRSLIIMGGWPIVLGLLIAAAATvvsshAYLWMTAGLSVYAFGIGVAN-AGLVRLTLFASDM 344
Cdd:cd17325  246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT-----SFWLLLLLLALLGLGLGLVFpATLALLADIVPPE 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 757782660 345 SKGTVSAAMGMLQMLIFTVGIELSkhAYLLGGNGLFSLFnLASGMLWLLLMFIFL 399
Cdd:cd17325  321 GRGTAMGLFNTAFSLGMVLGPLLG--GFLYDAFGFATPF-LAAAALLLLAAVLFL 372
MFS_1 pfam07690
Major Facilitator Superfamily;
58-364 1.79e-13

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 70.91  E-value: 1.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660   58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:pfam07690  38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPE 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  138 VCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGLQRAMPETATRIGEPLSLKALGNDYRLVLK 217
Cdd:pfam07690 118 ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  218 NGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGwpIVL 297
Cdd:pfam07690 198 LRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL--LLL 275

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 757782660  298 GLLIAAAATVVSSHAYLWMTAGLSVYAFGIGVANAGLVRLTLFASDMSK-GTVSAAMGMLQMLIFTVG 364
Cdd:pfam07690 276 ILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEErGTASGLYNTAGSLGGALG 343
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 71-365 5.97e-13

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 69.51  E-value: 5.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  71 LLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVA 150
Cdd:cd17321   50 LAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVV 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 151 LIAPLLGPLVGAAWVHVLPWEGMFVlfaalaaiaffglqrampetatrIGEPLSLKALgndyrLVLKNgrFVAGALALGF 230
Cdd:cd17321  130 GIGAALGPLLGGLLLELFGWRWIFL-----------------------INVPIGLVAL-----LLART--FSGAVLAAFL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 231 VSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGwpIVLGLLIAAAATVVSS 310
Cdd:cd17321  180 LGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL--LLTAVGLLLLALLGAD 257

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 757782660 311 HAYLWMTAGLSVYAFGIGVANAGLVRLTLFASDMSK-GTVSAAMGMLQMLIFTVGI 365
Cdd:cd17321  258 SSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKaGAASGILNTARQLGGALGV 313
emrD PRK11652
multidrug transporter EmrD;
58-223 9.37e-13

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 69.17  E-value: 9.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:PRK11652  49 MAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGT 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 138 VCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGLQRAMPETATRIGEPlslKALGNDYRLVLK 217
Cdd:PRK11652 129 QLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPETRPADARR---TRVLASYRTLLS 205


                 ....*.
gi 757782660 218 NGRFVA 223
Cdd:PRK11652 206 NRRFNC 211
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
58-365 6.15e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 66.43  E-value: 6.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:COG2271   51 ASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 138 VCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFglqrampetatrigeplslkalgndyrlvlk 217
Cdd:COG2271  131 ERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL------------------------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 218 nGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRsliimGGWPIVL 297
Cdd:COG2271  180 -LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-----RKLVLAI 253

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 298 GLLIAAAATVVSSHA--YLWMTAGLSVYAFGIGVANAglVRLTLFASDMSKGTVSAAMGMLQMLIFTVGI 365
Cdd:COG2271  254 GLLLAALALLLLALLpsPALAIALLFLAGFGLGGAFG--LLWALAAELFPKKARGTASGLVNTFGFLGGA 321
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 27-170 9.46e-11

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 62.98  E-value: 9.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  27 FSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIE 106
Cdd:cd17323    9 FVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIA 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757782660 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPW 170
Cdd:cd17323   89 MLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGW 152
2_A_01_02 TIGR00880
Multidrug resistance protein;
59-195 1.89e-10

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 58.43  E-value: 1.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660   59 TAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAV 138
Cdd:TIGR00880   5 AGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEE 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 757782660  139 CIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGLQRAMPET 195
Cdd:TIGR00880  85 RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 58-365 3.56e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 61.03  E-value: 3.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:cd17324   40 VSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPE 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 138 VCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGLQRAMPETATRIGEPLSLKAlgnDYRLVLK 217
Cdd:cd17324  120 KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLS---SLLLLLR 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 218 NGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGWPIVL 297
Cdd:cd17324  197 NPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA 276

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 757782660 298 GLLIAAAAtvvssHAYLWMTAGLSVYAFGIGVANAGlvrLTLFASDMSKGTVSAAMGmLQMLIFTVGI 365
Cdd:cd17324  277 LLLLTLLG-----PSPLLLLVGLVLWGLGFFAAHSA---LQTRVLRLAPEARGLASS-LYLAAYNLGG 335
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
32-175 6.67e-10

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 60.42  E-value: 6.67e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  32 GNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLL 111
Cdd:PRK10473  18 GIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAG 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757782660 112 RFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFV 175
Cdd:PRK10473  98 RFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFY 161
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 67-397 1.06e-08

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 56.46  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  67 FLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGIslCFIGAVGYAAIQESFEEAVCIKITALM 146
Cdd:cd17472   47 IFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALI 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 147 ANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGLQRAMPETATRIGEPLSLKALgndYRLVLKNGRFVAGAL 226
Cdd:cd17472  125 GASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKK---LKKLLKNKRLLRLDF 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 227 ALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGgwpiVLGLLIAAAAT 306
Cdd:cd17472  202 SIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSS----ILLIAVGFLLL 277

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 307 VVSSHAYLWMTAGLSVYAFGIGVANAGLVRL-TLFASDMSKGTVSAAMGMLQMLIFTVGIELSKHAYLLGGNGLFSLFNL 385
Cdd:cd17472  278 LFAATSLWLLIIGLIIFFIGFNLLEALLPSLvSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTIL 357

                        330
                 ....*....|..
gi 757782660 386 ASGMLWLLLMFI 397
Cdd:cd17472  358 ILALLWLLVSFL 369
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 59-365 4.15e-08

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 54.49  E-value: 4.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  59 TAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAV 138
Cdd:cd17502   37 TAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 139 CIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVlfaalaaiaffglqrampetatrIGEPLSLKALgndyrLVLKN 218
Cdd:cd17502  117 RGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFY-----------------------INLPIGGLAL-----ALLRT 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 219 grFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTAR-RTVRSLIIMGGwpiVL 297
Cdd:cd17502  169 --ILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKtGRYKPLIVIGT---IL 243

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 298 GLLIAAAATVVSSHAYLWMTAGLSV-YAFGIGVAN-AGLVRLTLFASDMSKGTVSAAMGMLQMLIFTVGI 365
Cdd:cd17502  244 MSVGAGLLTTLTLDTSKWLLIGYLIlLGLGLGIGFqQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGV 313
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 58-175 4.85e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 54.51  E-value: 4.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:cd17365   40 GSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPAR 119

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 757782660 138 VCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFV 175
Cdd:cd17365  120 RRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFL 157
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
58-332 5.91e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.12  E-value: 5.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:COG2223   46 FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPD 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 138 VCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGLQRAMPETATriGEPLSLKALGNDYRLVLK 217
Cdd:COG2223  126 RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA--GAAAAAKASLRDQLEALR 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 218 NGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQ--VPIFGAL--IAGNLMLARLTARRTvrsLIIMGgw 293
Cdd:COG2223  204 DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAalFALLGALgrPLGGWLSDRIGGRRV---LLIVF-- 278

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 757782660 294 pivLGLLIAAAATVVSSHAYLWMTAGLSVYAFGIGVANA 332
Cdd:COG2223  279 ---ALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG 314
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 53-132 1.28e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 52.97  E-value: 1.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  53 WVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQE 132
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 75-365 1.45e-07

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 52.96  E-value: 1.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  75 LSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAP 154
Cdd:cd17503   54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 155 LLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFglqrampetatrIGEPLSLKalgndyrlVLKNGRFVAGALALGFVSLP 234
Cdd:cd17503  134 AIGPTLGGWLTDNLSWRWIFYINLPIGILALL------------LAPLLDLR--------LFKDRNFTLGLLLSFLLGLG 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 235 LLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLIIMGGWPIVLGLLIAAAATVVSShaYL 314
Cdd:cd17503  194 LFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDTS--LW 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 757782660 315 WMTAGLSVYAFGIGVANAGLVRLTLfaSDMSKGTVSAA---MGMLQMLIFTVGI 365
Cdd:cd17503  272 LIILPLFIRGLGMGLVFMPLNTLAL--NSLPPEQIGDAtalFNTIRQLGGSIGT 323
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 62-175 2.02e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 52.69  E-value: 2.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  62 LAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIK 141
Cdd:cd17371   44 LAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGK 123

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 757782660 142 ITALMANV----ALIAPLLGPLVGAAWVHVLPWEGMFV 175
Cdd:cd17371  124 ALGYVQSGwavgWLLATLLAALLFPLLPPEIAWRVLFL 161
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 58-196 2.15e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 52.74  E-value: 2.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660   58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:TIGR00895  58 FSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKR 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 757782660  138 VCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFGLQRAMPETA 196
Cdd:TIGR00895 138 FRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESI 196
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 35-364 2.64e-07

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 52.19  E-value: 2.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  35 MIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFL 114
Cdd:cd17504   14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 115 QGISLCFIGaVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAFFglqrAMPE 194
Cdd:cd17504   94 QGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAA----LVPL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 195 TATRIgepLSLKALGndyrLVLKNGRFVAGALALGFVSLPLLawiAQSPIIIISGeqLSSYEYGLLQVPIFGALIAGNLM 274
Cdd:cd17504  169 IDLRL---LRRRNVL----LANITALLAGFGMFMVFQLLPQL---LQLPTPTGFG--LGITEAGLLLLPGALVMLIAGPL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 275 LARLTARRTVRSLIIMGGwpIVLGLLIAAAATVVSSHAylWMTAGLSVYAFGIGVANAGLVRLTLFASDMSKgtVSAAMG 354
Cdd:cd17504  237 AGRLIARVGPRRVLLIGL--VISAVGLLLLALLHSSLW--ALVVALLLIGIGLGLAFASLPNIVVESVPPDR--TGIATG 310

                        330
                 ....*....|
gi 757782660 355 MLQmLIFTVG 364
Cdd:cd17504  311 MNT-VLRTIG 319
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 31-400 5.45e-07

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 51.08  E-value: 5.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  31 IGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLA-----GVVWFIVTCLATLLAQSI 105
Cdd:cd06173   13 LGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 106 EQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAALAAIAF 185
Cdd:cd06173   93 WLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSA 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 186 FGLQ--RAMPETATRIGEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVP 263
Cdd:cd06173  173 LLLLfiRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAA 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 264 IFGALIAGNLMLARLTARRTVRSLIIMGGWPIVLGLLIAAAatvvsSHAYLWMTAGLSVYAFGIGVANAGL-VRLTLFAS 342
Cdd:cd06173  253 FGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL-----SPSLWLLLAALFLLGLAGGLFNVPLnTLLQLRVP 327

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 757782660 343 DMSKGTVSAAMGMLQMLIFTVGIELSkhAYLLGGNGLFSLFNLASGMLWLLLMFIFLK 400
Cdd:cd06173  328 DELRGRVFSVYNALNSGAMPLGALLA--GLLADALGLSAVFLLAGALLLLAALLLLLL 383
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 41-169 9.61e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 50.29  E-value: 9.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  41 LAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLC 120
Cdd:cd17316   25 LAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIG 104

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 757782660 121 FIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLP 169
Cdd:cd17316  105 GEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLS 153
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 27-161 1.42e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 49.90  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  27 FSTYIGNDMIQPGMLAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIE 106
Cdd:cd17489    6 FFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 757782660 107 QFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVG 161
Cdd:cd17489   86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALG 140
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 58-356 1.83e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.41  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  58 MTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEA 137
Cdd:cd17319   44 ASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPAR 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 138 VCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFVLFAAlaaiaffglqrampetatrigepLSLKALGNDYRLVLK 217
Cdd:cd17319  124 ERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGL-----------------------LGLLLAVLWWFYLRQ 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 218 NGRFVAGALALGFVSLPLLAWIaqsPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSliimGGWPIVL 297
Cdd:cd17319  181 VWGLALGYFGINYALYGLLTWL---PTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA----RRLVIII 253

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 757782660 298 GLLIAAAATVVSSHAY-LWMT-AGLSVYAFGIGVANAGL-VRLTLFASDMSKGTVSAAMGML 356
Cdd:cd17319  254 GLLLAAVGLLLAYLTTsPVVAvILLSLAGFGIGAASPVFwSLPADLLPGEAAATAGGLINSG 315
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 22-326 3.24e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 45.68  E-value: 3.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  22 LVLYEFSTYIGNDMIQPGM-LAVVEQYQAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATL 100
Cdd:cd17329    4 LLIGSFLNRLGFFMVWPFMaIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 101 LAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVALIAPLLGPLVGaAWVHVLPWEGMFVLFAAL 180
Cdd:cd17329   84 FAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLG-GLLLLYSFRLLFLAAAVL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 181 AAIAFFGLQRAMPETATRIgEPLSLKALGNDYRLVLKNGRFVAGALALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLL 260
Cdd:cd17329  163 FLLAALVLLFLLPETRPKR-RAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLL 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 757782660 261 qVPIFGALI-AGNLMLARLTARRTVRSLIIMGgwpivLGLLIAAAATVVSSHAYLWMTAGLSVYAFG 326
Cdd:cd17329  242 -LALNALLIvLLQFPVARLVERFRLRKILMIG-----ILLFAIGFAVLAFANTLAVLILAMIVLTLG 302
MFS_YdiM_like cd17396
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ...
 72-174 1.72e-04

Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340954 [Multi-domain]  Cd Length: 384  Bit Score: 43.49  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  72 LGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIKITALMANVAL 151
Cdd:cd17396   55 AGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPKASGSANILVKAFVSF 134

                         90       100
                 ....*....|....*....|...
gi 757782660 152 IAPLLGPLVGAawvhvLPWEGMF 174
Cdd:cd17396  135 GQFLLPFIIAF-----LAANNLW 152
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 54-117 2.06e-04

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 43.23  E-value: 2.06e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 757782660  54 VPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGI 117
Cdd:cd17377   41 VSLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGV 104
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
20-131 7.90e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 7.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  20 LCLVLYEFSTYIGNDMIQPGMLAVVEQY-QAGIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLA 98
Cdd:COG2211  231 LLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                         90       100       110
                 ....*....|....*....|....*....|...
gi 757782660  99 TLLAQSiEQFTLLrflqgISLCFIGAVGYAAIQ 131
Cdd:COG2211  311 LFFLGP-GNLWLL-----LVLAALAGIGLGAIL 337
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 55-119 8.79e-04

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 41.12  E-value: 8.79e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 757782660  55 PTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISL 119
Cdd:cd17374   38 SVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAV 102
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 52-163 5.71e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.69  E-value: 5.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  52 DWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQ 131
Cdd:cd17477   31 ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLN 110

                         90       100       110
                 ....*....|....*....|....*....|..
gi 757782660 132 ESFEEAVCIKITALMANVALIAPLLGPLVGAA 163
Cdd:cd17477  111 ALATNENRGRVLGLYSTVLGLGFALGPLLLAL 142
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 64-117 6.51e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 38.71  E-value: 6.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 757782660  64 GGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGI 117
Cdd:cd17358   53 GALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGF 106
Sugar_tr pfam00083
Sugar (and other) transporter;
60-119 6.64e-03

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 38.41  E-value: 6.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 757782660   60 AYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVT---CLATLLAQSIEQFTLLRFLQGISL 119
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGavlQGAAKGKWSVYQLIVGRVLVGIGV 116
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 50-175 6.75e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 38.31  E-value: 6.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  50 GIDWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLA-TLLAQSIEQFTLLRFLQGISLCFIGAVGYA 128
Cdd:cd17477  221 SVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLlPLVPGLPLALLVLLFLWGGAAGPLYTLALA 300

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 757782660 129 AIQESFEEAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFV 175
Cdd:cd17477  301 LAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFL 347
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 62-128 7.48e-03

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 38.29  E-value: 7.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 757782660  62 LAGGMFLQWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYA 128
Cdd:cd17444   46 LVGLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYA 112
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
58-175 7.86e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 38.31  E-value: 7.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  58 MTAYLAGGMFLQWLLGPLSDRIGRR--PVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFE 135
Cdd:COG2271  222 LSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 757782660 136 EAVCIKITALMANVALIAPLLGPLVGAAWVHVLPWEGMFV 175
Cdd:COG2271  302 KKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 71-361 8.59e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 37.94  E-value: 8.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  71 LLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFIGAVGYAAIQESFEEAVCIK----ITALM 146
Cdd:cd17473   54 LAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKmlglQSAAM 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 147 ANVALIAPLLGPLVGAawvhvLPWEGMFVLFAALAAIAFFGLqRAMPETATRIGEPLSLKALGNDYrlvLKNGRFVAGAL 226
Cdd:cd17473  134 SLGGVVFLLLGGALAE-----IGWRAPFLVYLLALPVLILVL-LFLPEPARKSKSAASPGAATAAA---LPWKRVLPIYF 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660 227 ALGFVSLPLLAWIAQSPIIIISGEQLSSYEYGLLQVPIFGALIAGNLMLARLTARRTVRSLiimggwpIVLGLLIAAAAT 306
Cdd:cd17473  205 LAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRL-------LAIGFALMALGF 277

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 757782660 307 VVSSHAYLWMTAGLSVYAFGIGVANAGLVRLTLFASDMSKGTVSAAMGMLQMLIF 361
Cdd:cd17473  278 LLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFF 332
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 53-122 9.06e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 38.01  E-value: 9.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757782660  53 WVPTSMTayLAGGMFLqWLLGPLSDRIGRRPVMLAGVVWFIVTCLATLLAQSIEQFTLLRFLQGISLCFI 122
Cdd:cd17476   37 WLAASYS--LTVGTFI-LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFL 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH