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Conserved domains on  [gi|757599193|ref|WP_042846839|]
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MULTISPECIES: phosphoethanolamine transferase CptA [Providencia]

Protein Classification

alkaline phosphatase family protein( domain architecture ID 581061)

alkaline phosphatase (ALP) family protein may catalyze the hydrolysis of substrates; the ALP superfamily includes alkaline phosphatases and sulfatases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ALP_like super family cl23718
alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and ...
 11-567 0e+00

alkaline phosphatases and sulfatases; This family includes alkaline phosphatases and sulfatases. Alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH. Alkaline phosphatase exists as a dimer, each monomer binding 2 zinc atoms and one magnesium atom, which are essential for enzymatic activity. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. Both alkaline phosphatase and sulfatase are essential for human metabolism. Deficiency of individual enzyme cause genetic diseases.


The actual alignment was detected with superfamily member NF012179:

Pssm-ID: 474031  Cd Length: 556  Bit Score: 981.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  11 SWISLFWLLIYFWYFSSLLQLYVLVTGQSNSIGLRDSLLYSSLWLIPALLFPKKIKLVAGLIGIVLWLSSVVALAYFVVY 90
Cdd:NF012179   1 DWAGLGWLLLFFWYFSGLTQALILLSGTSGFAGFRDALLLSSLWLIPVLLFPRRTRLLAAVIGVVLWAASLAALSYFVIY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  91 GHQISQSVMFVMFETNTNEAGEFLKQYFSFKVVGVILAYTVVAIFLWTRLKPVTLPKSGRIGISLLILIILFGIPYYNKG 170
Cdd:NF012179  81 GQEFSQSVIFVMFESNTNEAGEYLSQYFSWWIVLALLAYTAVAILLWTRLRPVYLPRPWRWPVSVLLLVALIGYPLYKQT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 171 IKQDRPIANVASYVNSKLAYAAPWQFVSGYLLYKNQLANMEELIRDNSKIPPLENFVDANGNTPRTFVLVIGESTSRDRM 250
Cdd:NF012179 161 VIQHRPFADALEKVESRMEPAVPWQFVVGYRQYRQQLDNMQGLLNSNSALPPLANLKDSSGNAPRTLVLVIGESTQRGRM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 251 SLYGYTRPTTPELDELARDYPtNLSVFNDVVTSRPYTIEALQQILTFATQTEPELFNSRPSIMNMMKQAGFKTFWITNQQ 330
Cdd:NF012179 241 SLYGYPRETTPELDALKASDP-NLTVFNNVVTPRPYTIEALQQVLTFADEENPDLYLTTPSLMNMMKQAGYKTFWITNQQ 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 331 TMTERNTLLTAFSRQTDKQYYLNNDMAQSSRIYDDVVFAPFKEALADPAEKKFIVVHLLGTHMRYEFRYPEEKAIFKGKD 410
Cdd:NF012179 320 TMTKRNTMLTTFSQQTDEQVYLNNQRNQNARQYDGNVLAPFKKALADPAPKKFIVVHLLGTHMKYQYRYPEDYDKFTGRT 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 411 DVVPKNLNEDEVNDYNAYDNAQHYNDYVVSTLIKDFDSSKENGFLVFFSDHGEDVYDTPPHKMLGRSEGKPSKVIYNVPF 490
Cdd:NF012179 400 QGVPAGLSDDQLETYNSYDNAVLYNDFVVSSLIKDYAATDPNGFLLYLSDHGEDVYDSPPHDTLGRNEGKPTRPMYTIPF 479

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 757599193 491 LVWQSPEWLNTHQFDLNDKTTRPFSTMDFIYAWSDLAGLNYTGFESQKSLFNNEFKPQPRYIGDPENKSSLMLYDDL 567
Cdd:NF012179 480 LLWTSPKWQAAHPRDFSADVNRPYSSSHLIHTWSDLAGLSYDGYDPTKSLVSPQFKARPRWIGNPYKKNGLIDFDLL 556
 
Name Accession Description Interval E-value
CptA NF012179
phosphoethanolamine transferase CptA;
11-567 0e+00

phosphoethanolamine transferase CptA;


Pssm-ID: 333729  Cd Length: 556  Bit Score: 981.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  11 SWISLFWLLIYFWYFSSLLQLYVLVTGQSNSIGLRDSLLYSSLWLIPALLFPKKIKLVAGLIGIVLWLSSVVALAYFVVY 90
Cdd:NF012179   1 DWAGLGWLLLFFWYFSGLTQALILLSGTSGFAGFRDALLLSSLWLIPVLLFPRRTRLLAAVIGVVLWAASLAALSYFVIY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  91 GHQISQSVMFVMFETNTNEAGEFLKQYFSFKVVGVILAYTVVAIFLWTRLKPVTLPKSGRIGISLLILIILFGIPYYNKG 170
Cdd:NF012179  81 GQEFSQSVIFVMFESNTNEAGEYLSQYFSWWIVLALLAYTAVAILLWTRLRPVYLPRPWRWPVSVLLLVALIGYPLYKQT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 171 IKQDRPIANVASYVNSKLAYAAPWQFVSGYLLYKNQLANMEELIRDNSKIPPLENFVDANGNTPRTFVLVIGESTSRDRM 250
Cdd:NF012179 161 VIQHRPFADALEKVESRMEPAVPWQFVVGYRQYRQQLDNMQGLLNSNSALPPLANLKDSSGNAPRTLVLVIGESTQRGRM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 251 SLYGYTRPTTPELDELARDYPtNLSVFNDVVTSRPYTIEALQQILTFATQTEPELFNSRPSIMNMMKQAGFKTFWITNQQ 330
Cdd:NF012179 241 SLYGYPRETTPELDALKASDP-NLTVFNNVVTPRPYTIEALQQVLTFADEENPDLYLTTPSLMNMMKQAGYKTFWITNQQ 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 331 TMTERNTLLTAFSRQTDKQYYLNNDMAQSSRIYDDVVFAPFKEALADPAEKKFIVVHLLGTHMRYEFRYPEEKAIFKGKD 410
Cdd:NF012179 320 TMTKRNTMLTTFSQQTDEQVYLNNQRNQNARQYDGNVLAPFKKALADPAPKKFIVVHLLGTHMKYQYRYPEDYDKFTGRT 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 411 DVVPKNLNEDEVNDYNAYDNAQHYNDYVVSTLIKDFDSSKENGFLVFFSDHGEDVYDTPPHKMLGRSEGKPSKVIYNVPF 490
Cdd:NF012179 400 QGVPAGLSDDQLETYNSYDNAVLYNDFVVSSLIKDYAATDPNGFLLYLSDHGEDVYDSPPHDTLGRNEGKPTRPMYTIPF 479

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 757599193 491 LVWQSPEWLNTHQFDLNDKTTRPFSTMDFIYAWSDLAGLNYTGFESQKSLFNNEFKPQPRYIGDPENKSSLMLYDDL 567
Cdd:NF012179 480 LLWTSPKWQAAHPRDFSADVNRPYSSSHLIHTWSDLAGLSYDGYDPTKSLVSPQFKARPRWIGNPYKKNGLIDFDLL 556
PRK10649 PRK10649
phosphoethanolamine transferase CptA;
1-568 0e+00

phosphoethanolamine transferase CptA;


Pssm-ID: 182617 [Multi-domain]  Cd Length: 577  Bit Score: 813.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193   1 MVNTTRSAR--FSWISLFWLLIYFWYFSSLLQLYVLVTGQSNSIGLRDSLLYSSLWLIPALLFPKKIKLVAGLIGIVLWL 78
Cdd:PRK10649   1 MHSTKVQAKplFSWKALGWALLFFWFFSTLLQAIIYISGYSGTNGFRDALLFSSLWLIPVFLFPRRIRIIAAVIGVVLWA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  79 SSVVALAYFVVYGHQISQSVMFVMFETNTNEAGEFLKQYFSFKVVGVILAYTVVAIFLWTRLKPVTLPKSGRIGISLLIL 158
Cdd:PRK10649  81 ASLAALCYYVIYGQEFSQSVLFVMFETNTNEASEYLSQYFSLKIVLIALAYTAVAVLLWTRLRPVYIPWPWRYVVSFALL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 159 IILFGIPYYNKGIKQDRPIANVASYVNSKLAYAAPWQFVSGYLLYKNQLANMEELIRDNSKIPPLENFVDANGNTPRTFV 238
Cdd:PRK10649 161 YGLILHPIAMNTFIKHKPFEKTLDKLASRMEPAAPWQFLTGYYQYRQQLNSLQKLLNENAALPPLANLKDESGNAPRTLV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 239 LVIGESTSRDRMSLYGYTRPTTPELDELaRDYPTNLSVFNDVVTSRPYTIEALQQILTFATQTEPELFNSRPSIMNMMKQ 318
Cdd:PRK10649 241 LVIGESTQRGRMSLYGYPRETTPELDAL-HKTDPGLTVFNNVVTSRPYTIEILQQALTFADEKNPDLYLTQPSLMNMMKQ 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 319 AGFKTFWITNQQTMTERNTLLTAFSRQTDKQYYLNNDMAQSSRIYDDVVFAPFKEALADPAEKKFIVVHLLGTHMRYEFR 398
Cdd:PRK10649 320 AGYKTFWITNQQTMTARNTMLTVFSRQTDKQYYMNQQRTQNAREYDTNVLKPFSEVLADPAPKKFIIVHLLGTHIKYKYR 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 399 YPEEKAIFKGKDDVVPKNLNEDEVNDYNAYDNAQHYNDYVVSTLIKDFDSSKENGFLVFFSDHGEDVYDTPPHKMLGRSE 478
Cdd:PRK10649 400 YPENQGKFDDRTGHVPPGLNADELESYNDYDNANLYNDHVVASLIKDFKATDPNGFLVYFSDHGEEVYDTPPHKTQGRNE 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 479 GKPSKVIYNVPFLVWQSPEWLNTHQFDLNDKTTRPFSTMDFIYAWSDLAGLNYTGFESQKSLFNNEFKPQPRYIGDPENK 558
Cdd:PRK10649 480 DNPTRHMYTIPFLLWTSEKWQAAHPRDFSQDVDRKYSLAELIHTWSDLAGLSYDGYDPTRSLVNPQFKETPRWIGNPYKK 559

                        570
                 ....*....|
gi 757599193 559 SSLMLYDDLK 568
Cdd:PRK10649 560 NALIDYDTLP 569
LptA cd16017
Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine ...
 233-530 5.60e-97

Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase; Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.


Pssm-ID: 293741 [Multi-domain]  Cd Length: 288  Bit Score: 296.84  E-value: 5.60e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 233 TPRTFVLVIGESTSRDRMSLYGYTRPTTPELDELARdyptNLSVFNDVVTSRPYTIEALQQILTFATQTEPELFNSRPSI 312
Cdd:cd16017    1 KPKNVVLVIGESARRDHMSLYGYPRDTTPFLSKLKK----NLIVFDNVISCGTSTAVSLPCMLSFANRENYDRAYYQENL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 313 MNMMKQAGFKTFWITNQQTMTERNTLLTAFSRQTdkQYYLNNDMAQSSRIYDDVVFAPFKEALADPAEKKFIVVHLLGTH 392
Cdd:cd16017   77 IDLAKKAGYKTYWISNQGGCGGYDTRISAIAKIE--TVFTNKGSCNSSNCYDEALLPLLDEALADSSKKKLIVLHLMGSH 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 393 MRYEFRYPEEKAIFKGKDDVVPKNLNEDEVndYNAYDNAQHYNDYVVSTLIKDFDSSKENGFLVFFSDHGEDVYDtppHK 472
Cdd:cd16017  155 GPYYDRYPEEFAKFTPDCDNELQSCSKEEL--INAYDNSILYTDYVLSQIIERLKKKDKDAALIYFSDHGESLGE---NG 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 757599193 473 MLGRSEGKPSKVIYNVPFLVWQSPEWLNTHQFD-LNDKTTRPFSTMDFIYAWSDLAGLN 530
Cdd:cd16017  230 LYLHGAPYAPKEQYHVPFIIWSSDSYKQRYPVErLRANKDRPFSHDNLFHTLLGLLGIK 288
OpgE COG2194
Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall ...
 6-547 3.86e-68

Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441797 [Multi-domain]  Cd Length: 537  Bit Score: 229.74  E-value: 3.86e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193   6 RSARFSWI-SLFWLLIYFWYFssLLQLYVLVTGQSNSIGLRDSLLYSSLWLIPALLFPKKIKLVAGLIGIVLWLSSVVAL 84
Cdd:COG2194    8 SPLKLILLlALYFALFLNLPF--WGRLLAILPLDGVNLLFLLSLPLLLLAALNLLLSLLAWRYLFKPLLILLLLISAAAS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  85 AYFVVYGHQISQSVMFVMFETNTNEAGEFLkqyfSFKVVGVILAYTVV--AIFLWTRLKPVTLPKSGRIGISLLILI--- 159
Cdd:COG2194   86 YFMDFYGVVIDYGMIQNVLETDPAEASELL----SPKLILWLLLLGVLpaLLLWRVRIRYRPLLRELGQRLALLLLAllv 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 160 -ILFGIPYYnkgikqdrpiANVASYV--NSKLAYAA-PWQFVSGYLLYKNQLANMEEL----IRDNSKIPPlenfvdaNG 231
Cdd:COG2194  162 iVLLALLFY----------KDYASFFrnHKELRYLInPSNFIYALGKYAKARYFAAPLplqpLGADAKLAA-------AG 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 232 NTPRTFVLVIGESTSRDRMSLYGYTRPTTPELDELArdyptNLSVFNDVVTSRPYTIEALQQILTFATQTE--PELFNSR 309
Cdd:COG2194  225 AKPTLVVLVVGETARADNFSLNGYARDTTPELAKEK-----NLVSFRDVTSCGTATAVSVPCMFSRLGRADydPQRALNQ 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 310 PSIMNMMKQAGFKTFWITNQQTMTERNTLLTAFSRQTDKqyylNNDMAQSSRIYDDVVFAPFKEALADPAEKKFIVVHLL 389
Cdd:COG2194  300 ENLLDVLQRAGVKVLWRDNQSGCKGVCDRVPTIDLTADN----LPPLCDGGECLDEVLLDGLDEALADLAGDKLIVLHQM 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 390 GTH-MRYEFRYPEEKAIFKGKDDV-VPKNLNEDEVNdyNAYDNAQHYNDYVVSTLIKDFDS--SKENGFLVFFSDHGEDV 465
Cdd:COG2194  376 GSHgPAYYKRYPPEFRKFTPTCDTnDLQNCSREELV--NAYDNTILYTDYVLSQVIDLLKAkqDRYDTAMLYVSDHGESL 453

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 466 YDT------PPHKMlgrsegkPSKVIYNVPFLVWQSPEWLNTHQFD---LNDKTTRPFSTMDFIYAWSDLAGLNYTGFES 536
Cdd:COG2194  454 GENglylhgTPYAI-------APDEQTHVPMIMWLSDGYAQRYGIDfacLKARADKPYSHDNLFHTLLGLLDVRTSVYDP 526

                        570
                 ....*....|.
gi 757599193 537 QKSLFNNEFKP 547
Cdd:COG2194  527 ELDILAPCRRA 537
Sulfatase pfam00884
Sulfatase;
235-529 5.61e-49

Sulfatase;


Pssm-ID: 459979 [Multi-domain]  Cd Length: 298  Bit Score: 171.84  E-value: 5.61e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  235 RTFVLVIGESTSRDRMSLYGYTRPTTPELDELArdypTNLSVFNDVVTSRPYTIEALQQILT--------FATQTEPELF 306
Cdd:pfam00884   1 PNVVLVLGESLRAPDLGLYGYPRPTTPFLDRLA----EEGLLFSNFYSGGTLTAPSRFALLTglpphnfgSYVSTPVGLP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  307 NSRPSIMNMMKQAGFKT--------FWITNQ-------QTMTERNTLLTAFSRQTDKQYYLNNDMAqssriYDDVVFAPF 371
Cdd:pfam00884  77 RTEPSLPDLLKRAGYNTgaigkwhlGWYNNQspcnlgfDKFFGRNTGSDLYADPPDVPYNCSGGGV-----SDEALLDEA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  372 KEALADPAEKKFIVVHLLGTHMRYEF--RYPEEKAIFKGkddvvpknLNEDEVNDYNAYDNAQHYNDYVVSTLIKDFDSS 449
Cdd:pfam00884 152 LEFLDNNDKPFFLVLHTLGSHGPPYYpdRYPEKYATFKP--------SSCSEEQLLNSYDNTLLYTDDAIGRVLDKLEEN 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  450 --KENGFLVFFSDHGEDVYDTPPHKMLGRSEGKPsKVIYNVPFLVWQSPEWlntHQFDLNDKTTrpfSTMDFIYAWSDLA 527
Cdd:pfam00884 224 glLDNTLVVYTSDHGESLGEGGGYLHGGKYDNAP-EGGYRVPLLIWSPGGK---AKGQKSEALV---SHVDLFPTILDLA 296


                  ..
gi 757599193  528 GL 529
Cdd:pfam00884 297 GI 298
 
Name Accession Description Interval E-value
CptA NF012179
phosphoethanolamine transferase CptA;
11-567 0e+00

phosphoethanolamine transferase CptA;


Pssm-ID: 333729  Cd Length: 556  Bit Score: 981.82  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  11 SWISLFWLLIYFWYFSSLLQLYVLVTGQSNSIGLRDSLLYSSLWLIPALLFPKKIKLVAGLIGIVLWLSSVVALAYFVVY 90
Cdd:NF012179   1 DWAGLGWLLLFFWYFSGLTQALILLSGTSGFAGFRDALLLSSLWLIPVLLFPRRTRLLAAVIGVVLWAASLAALSYFVIY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  91 GHQISQSVMFVMFETNTNEAGEFLKQYFSFKVVGVILAYTVVAIFLWTRLKPVTLPKSGRIGISLLILIILFGIPYYNKG 170
Cdd:NF012179  81 GQEFSQSVIFVMFESNTNEAGEYLSQYFSWWIVLALLAYTAVAILLWTRLRPVYLPRPWRWPVSVLLLVALIGYPLYKQT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 171 IKQDRPIANVASYVNSKLAYAAPWQFVSGYLLYKNQLANMEELIRDNSKIPPLENFVDANGNTPRTFVLVIGESTSRDRM 250
Cdd:NF012179 161 VIQHRPFADALEKVESRMEPAVPWQFVVGYRQYRQQLDNMQGLLNSNSALPPLANLKDSSGNAPRTLVLVIGESTQRGRM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 251 SLYGYTRPTTPELDELARDYPtNLSVFNDVVTSRPYTIEALQQILTFATQTEPELFNSRPSIMNMMKQAGFKTFWITNQQ 330
Cdd:NF012179 241 SLYGYPRETTPELDALKASDP-NLTVFNNVVTPRPYTIEALQQVLTFADEENPDLYLTTPSLMNMMKQAGYKTFWITNQQ 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 331 TMTERNTLLTAFSRQTDKQYYLNNDMAQSSRIYDDVVFAPFKEALADPAEKKFIVVHLLGTHMRYEFRYPEEKAIFKGKD 410
Cdd:NF012179 320 TMTKRNTMLTTFSQQTDEQVYLNNQRNQNARQYDGNVLAPFKKALADPAPKKFIVVHLLGTHMKYQYRYPEDYDKFTGRT 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 411 DVVPKNLNEDEVNDYNAYDNAQHYNDYVVSTLIKDFDSSKENGFLVFFSDHGEDVYDTPPHKMLGRSEGKPSKVIYNVPF 490
Cdd:NF012179 400 QGVPAGLSDDQLETYNSYDNAVLYNDFVVSSLIKDYAATDPNGFLLYLSDHGEDVYDSPPHDTLGRNEGKPTRPMYTIPF 479

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 757599193 491 LVWQSPEWLNTHQFDLNDKTTRPFSTMDFIYAWSDLAGLNYTGFESQKSLFNNEFKPQPRYIGDPENKSSLMLYDDL 567
Cdd:NF012179 480 LLWTSPKWQAAHPRDFSADVNRPYSSSHLIHTWSDLAGLSYDGYDPTKSLVSPQFKARPRWIGNPYKKNGLIDFDLL 556
PRK10649 PRK10649
phosphoethanolamine transferase CptA;
1-568 0e+00

phosphoethanolamine transferase CptA;


Pssm-ID: 182617 [Multi-domain]  Cd Length: 577  Bit Score: 813.94  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193   1 MVNTTRSAR--FSWISLFWLLIYFWYFSSLLQLYVLVTGQSNSIGLRDSLLYSSLWLIPALLFPKKIKLVAGLIGIVLWL 78
Cdd:PRK10649   1 MHSTKVQAKplFSWKALGWALLFFWFFSTLLQAIIYISGYSGTNGFRDALLFSSLWLIPVFLFPRRIRIIAAVIGVVLWA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  79 SSVVALAYFVVYGHQISQSVMFVMFETNTNEAGEFLKQYFSFKVVGVILAYTVVAIFLWTRLKPVTLPKSGRIGISLLIL 158
Cdd:PRK10649  81 ASLAALCYYVIYGQEFSQSVLFVMFETNTNEASEYLSQYFSLKIVLIALAYTAVAVLLWTRLRPVYIPWPWRYVVSFALL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 159 IILFGIPYYNKGIKQDRPIANVASYVNSKLAYAAPWQFVSGYLLYKNQLANMEELIRDNSKIPPLENFVDANGNTPRTFV 238
Cdd:PRK10649 161 YGLILHPIAMNTFIKHKPFEKTLDKLASRMEPAAPWQFLTGYYQYRQQLNSLQKLLNENAALPPLANLKDESGNAPRTLV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 239 LVIGESTSRDRMSLYGYTRPTTPELDELaRDYPTNLSVFNDVVTSRPYTIEALQQILTFATQTEPELFNSRPSIMNMMKQ 318
Cdd:PRK10649 241 LVIGESTQRGRMSLYGYPRETTPELDAL-HKTDPGLTVFNNVVTSRPYTIEILQQALTFADEKNPDLYLTQPSLMNMMKQ 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 319 AGFKTFWITNQQTMTERNTLLTAFSRQTDKQYYLNNDMAQSSRIYDDVVFAPFKEALADPAEKKFIVVHLLGTHMRYEFR 398
Cdd:PRK10649 320 AGYKTFWITNQQTMTARNTMLTVFSRQTDKQYYMNQQRTQNAREYDTNVLKPFSEVLADPAPKKFIIVHLLGTHIKYKYR 399

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 399 YPEEKAIFKGKDDVVPKNLNEDEVNDYNAYDNAQHYNDYVVSTLIKDFDSSKENGFLVFFSDHGEDVYDTPPHKMLGRSE 478
Cdd:PRK10649 400 YPENQGKFDDRTGHVPPGLNADELESYNDYDNANLYNDHVVASLIKDFKATDPNGFLVYFSDHGEEVYDTPPHKTQGRNE 479

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 479 GKPSKVIYNVPFLVWQSPEWLNTHQFDLNDKTTRPFSTMDFIYAWSDLAGLNYTGFESQKSLFNNEFKPQPRYIGDPENK 558
Cdd:PRK10649 480 DNPTRHMYTIPFLLWTSEKWQAAHPRDFSQDVDRKYSLAELIHTWSDLAGLSYDGYDPTRSLVNPQFKETPRWIGNPYKK 559

                        570
                 ....*....|
gi 757599193 559 SSLMLYDDLK 568
Cdd:PRK10649 560 NALIDYDTLP 569
LptA cd16017
Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine ...
 233-530 5.60e-97

Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase; Lipooligosaccharide Phosphoethanolamine Transferase A (LptA) or Lipid A Phosphoethanolamine Transferase catalyzes the modification of the lipid A headgroups by phosphoethanolamine (PEA) or 4-amino-arabinose residues. Lipopolysaccharides, also called endotoxins, protect bacterial pathogens from antimicrobial peptides and have roles in virulence. The PEA modified lipid A increases resistance to the cationic cyclic polypeptide antibiotic, polymyxin. Lipid A PEA transferases usually consist of a transmembrane domain anchoring the enzyme to the periplasmic face of the cytoplasmic membrane.


Pssm-ID: 293741 [Multi-domain]  Cd Length: 288  Bit Score: 296.84  E-value: 5.60e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 233 TPRTFVLVIGESTSRDRMSLYGYTRPTTPELDELARdyptNLSVFNDVVTSRPYTIEALQQILTFATQTEPELFNSRPSI 312
Cdd:cd16017    1 KPKNVVLVIGESARRDHMSLYGYPRDTTPFLSKLKK----NLIVFDNVISCGTSTAVSLPCMLSFANRENYDRAYYQENL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 313 MNMMKQAGFKTFWITNQQTMTERNTLLTAFSRQTdkQYYLNNDMAQSSRIYDDVVFAPFKEALADPAEKKFIVVHLLGTH 392
Cdd:cd16017   77 IDLAKKAGYKTYWISNQGGCGGYDTRISAIAKIE--TVFTNKGSCNSSNCYDEALLPLLDEALADSSKKKLIVLHLMGSH 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 393 MRYEFRYPEEKAIFKGKDDVVPKNLNEDEVndYNAYDNAQHYNDYVVSTLIKDFDSSKENGFLVFFSDHGEDVYDtppHK 472
Cdd:cd16017  155 GPYYDRYPEEFAKFTPDCDNELQSCSKEEL--INAYDNSILYTDYVLSQIIERLKKKDKDAALIYFSDHGESLGE---NG 229

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 757599193 473 MLGRSEGKPSKVIYNVPFLVWQSPEWLNTHQFD-LNDKTTRPFSTMDFIYAWSDLAGLN 530
Cdd:cd16017  230 LYLHGAPYAPKEQYHVPFIIWSSDSYKQRYPVErLRANKDRPFSHDNLFHTLLGLLGIK 288
OpgE COG2194
Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall ...
 6-547 3.86e-68

Phosphoethanolamine transferase for periplasmic glucans OpgE, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441797 [Multi-domain]  Cd Length: 537  Bit Score: 229.74  E-value: 3.86e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193   6 RSARFSWI-SLFWLLIYFWYFssLLQLYVLVTGQSNSIGLRDSLLYSSLWLIPALLFPKKIKLVAGLIGIVLWLSSVVAL 84
Cdd:COG2194    8 SPLKLILLlALYFALFLNLPF--WGRLLAILPLDGVNLLFLLSLPLLLLAALNLLLSLLAWRYLFKPLLILLLLISAAAS 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  85 AYFVVYGHQISQSVMFVMFETNTNEAGEFLkqyfSFKVVGVILAYTVV--AIFLWTRLKPVTLPKSGRIGISLLILI--- 159
Cdd:COG2194   86 YFMDFYGVVIDYGMIQNVLETDPAEASELL----SPKLILWLLLLGVLpaLLLWRVRIRYRPLLRELGQRLALLLLAllv 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 160 -ILFGIPYYnkgikqdrpiANVASYV--NSKLAYAA-PWQFVSGYLLYKNQLANMEEL----IRDNSKIPPlenfvdaNG 231
Cdd:COG2194  162 iVLLALLFY----------KDYASFFrnHKELRYLInPSNFIYALGKYAKARYFAAPLplqpLGADAKLAA-------AG 224

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 232 NTPRTFVLVIGESTSRDRMSLYGYTRPTTPELDELArdyptNLSVFNDVVTSRPYTIEALQQILTFATQTE--PELFNSR 309
Cdd:COG2194  225 AKPTLVVLVVGETARADNFSLNGYARDTTPELAKEK-----NLVSFRDVTSCGTATAVSVPCMFSRLGRADydPQRALNQ 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 310 PSIMNMMKQAGFKTFWITNQQTMTERNTLLTAFSRQTDKqyylNNDMAQSSRIYDDVVFAPFKEALADPAEKKFIVVHLL 389
Cdd:COG2194  300 ENLLDVLQRAGVKVLWRDNQSGCKGVCDRVPTIDLTADN----LPPLCDGGECLDEVLLDGLDEALADLAGDKLIVLHQM 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 390 GTH-MRYEFRYPEEKAIFKGKDDV-VPKNLNEDEVNdyNAYDNAQHYNDYVVSTLIKDFDS--SKENGFLVFFSDHGEDV 465
Cdd:COG2194  376 GSHgPAYYKRYPPEFRKFTPTCDTnDLQNCSREELV--NAYDNTILYTDYVLSQVIDLLKAkqDRYDTAMLYVSDHGESL 453

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 466 YDT------PPHKMlgrsegkPSKVIYNVPFLVWQSPEWLNTHQFD---LNDKTTRPFSTMDFIYAWSDLAGLNYTGFES 536
Cdd:COG2194  454 GENglylhgTPYAI-------APDEQTHVPMIMWLSDGYAQRYGIDfacLKARADKPYSHDNLFHTLLGLLDVRTSVYDP 526

                        570
                 ....*....|.
gi 757599193 537 QKSLFNNEFKP 547
Cdd:COG2194  527 ELDILAPCRRA 537
Sulfatase pfam00884
Sulfatase;
235-529 5.61e-49

Sulfatase;


Pssm-ID: 459979 [Multi-domain]  Cd Length: 298  Bit Score: 171.84  E-value: 5.61e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  235 RTFVLVIGESTSRDRMSLYGYTRPTTPELDELArdypTNLSVFNDVVTSRPYTIEALQQILT--------FATQTEPELF 306
Cdd:pfam00884   1 PNVVLVLGESLRAPDLGLYGYPRPTTPFLDRLA----EEGLLFSNFYSGGTLTAPSRFALLTglpphnfgSYVSTPVGLP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  307 NSRPSIMNMMKQAGFKT--------FWITNQ-------QTMTERNTLLTAFSRQTDKQYYLNNDMAqssriYDDVVFAPF 371
Cdd:pfam00884  77 RTEPSLPDLLKRAGYNTgaigkwhlGWYNNQspcnlgfDKFFGRNTGSDLYADPPDVPYNCSGGGV-----SDEALLDEA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  372 KEALADPAEKKFIVVHLLGTHMRYEF--RYPEEKAIFKGkddvvpknLNEDEVNDYNAYDNAQHYNDYVVSTLIKDFDSS 449
Cdd:pfam00884 152 LEFLDNNDKPFFLVLHTLGSHGPPYYpdRYPEKYATFKP--------SSCSEEQLLNSYDNTLLYTDDAIGRVLDKLEEN 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  450 --KENGFLVFFSDHGEDVYDTPPHKMLGRSEGKPsKVIYNVPFLVWQSPEWlntHQFDLNDKTTrpfSTMDFIYAWSDLA 527
Cdd:pfam00884 224 glLDNTLVVYTSDHGESLGEGGGYLHGGKYDNAP-EGGYRVPLLIWSPGGK---AKGQKSEALV---SHVDLFPTILDLA 296


                  ..
gi 757599193  528 GL 529
Cdd:pfam00884 297 GI 298
PRK09598 PRK09598
phosphoethanolamine--lipid A transferase EptA;
66-544 7.33e-32

phosphoethanolamine--lipid A transferase EptA;


Pssm-ID: 236581 [Multi-domain]  Cd Length: 522  Bit Score: 129.13  E-value: 7.33e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  66 KLVAGLIGIVLWLSSVVALAYFVVYGHQISQSVMFVMFETNTNEAGEFL--KQYFSFKVVGVILAYTVVAIflwtRLKpv 143
Cdd:PRK09598  71 RRLMRLSAIVFSLLNSIAFYFINTYKVFLNKSMMGNVLNTNTAESSGFLsvKLFIYIVVLGVLPGYIIYKI----PLK-- 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 144 tlpKSGRIGISLLILIILFgipyynkgIKQDRPIANVASYV----NSKL--AYAAPWQFVSGYLLYKNQLA--NMEELIR 215
Cdd:PRK09598 145 ---NSSKKAPFAAILALVL--------IFLASAFANSKNWLwfdkHAKFlgGLILPWSYSVNTFRVSAHKFfaPTIKPLL 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 216 DNSKIPPLENFVdangntprtFVLVIGESTSRDRMSLYGYTRPTTPELDELARDYPtnLSVFNdVVTSRPYTIEALQQIL 295
Cdd:PRK09598 214 PPLFSPNHSKSV---------VVLVIGESARKHNYALYGYEKPTNPRLSKRLATHE--LTLFN-ATSCATYTTASLECIL 281

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 296 TFATQTEPELFNSRPsimNMMKQAGFKTFWITNQQTmtERNTLLTAFsrqtDKQYYLNNDMAQSSRIYDDVVFAPFKEAL 375
Cdd:PRK09598 282 DSSFKNTSNAYENLP---TYLTRAGIKVFWRSANDG--EPNVKVTSY----LKNYELIQKCPNCEAPYDESLLYNLPELI 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 376 -ADPAEKKFIVVHLLGTH-MRYEFRYPEEKAIFKGK-DDVVPKNLNEDEVndYNAYDNAQHYNDYVVSTLIKDFDSSKEN 452
Cdd:PRK09598 353 kASSNENVLLILHLAGSHgPNYDNKYPLNFRVFKPVcSSVELSSCSKESL--INAYDNTIFYNDYLLDKIISMLKNLKQP 430

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 453 GFLVFFSDHGEDVYDTPPHkMLGRSEGKPSKVIYNVPFLVWQSPEWLNTHqfdLNDKTTRPfSTMDFIYAwsdlAGLNYT 532
Cdd:PRK09598 431 ALMIYLSDHGESLGEGAFY-LHGIPKSIAPKEQYEIPFIVWASDSFKKQH---SIIQTQTP-INQNVIFH----SVLGVF 501

                        490
                 ....*....|..
gi 757599193 533 GFESQKSLFNNE 544
Cdd:PRK09598 502 DFKNPSAVYRPS 513
MdoB COG1368
Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope ...
 12-547 1.63e-23

Phosphoglycerol transferase MdoB/OpgB, AlkP superfamily [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440979 [Multi-domain]  Cd Length: 576  Bit Score: 104.74  E-value: 1.63e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  12 WISLFWLLIYFWYFSSLLQLYVLVtgQSNSIGLRDSLLYSSLWLI------PALLFPKKIKLVAGLIGIVLWLSSVVA-L 84
Cdd:COG1368    5 FLLLLSLRLVFLLFNFDLSLGEIL--QAFLYGLRFILYLLLLLLLllllllPLLFRRPKLRWIYLLLVLLLLLLLLVAdI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  85 AYFVVYGHQISQSVMFVMfeTNTNEAGEFLKQYFSFKVVGVILAYTVVAIFLWTRLKPVTLPKSGRIGISLLILIILFGI 164
Cdd:COG1368   83 LYYRFFGDRLNFSDLDYL--GDTGEVLGSLLSSYDLLLLLDLLLLLLLLLLLYRLLKKLRKSLPWRKRLALLLLLLALLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 165 PYYNkgIKQDRPI----ANVASYVNSKLAYAAPWQFVSGYLLYK-NQLANMEELIRDNSKIPPLENFVDANGNT-PRTFV 238
Cdd:COG1368  161 LGIR--LGEDRPLnlsdAFSRNNFVNELGLNGPYSFYDALRNNKaPATYSEEEALEIKKYLKSNRPTPNPFGPAkKPNVV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 239 LVIGESTSRDRMSLYGYTRPTTPELDELARDYptnlSVFNDVVTSRPYTIEALQQILT--FATQTEP----ELFNSRPSI 312
Cdd:COG1368  239 VILLESFSDFFIGALGNGKDVTPFLDSLAKES----LYFGNFYSQGGRTSRGEFAVLTglPPLPGGSpykrPGQNNFPSL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 313 MNMMKQAGFKT-FWITNQQTMTERNTLLTA--FSRQTDKQYYlNNDMAQSSRIYDDVVFAPFKEALADPAEKKFIVVHLL 389
Cdd:COG1368  315 PSILKKQGYETsFFHGGDGSFWNRDSFYKNlgFDEFYDREDF-DDPFDGGWGVSDEDLFDKALEELEKLKKPFFAFLITL 393

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 390 GTHMRYEfrYPEEKaifkgkddvvpKNLNEDEVNDYNAYDNAQHYNDYVVSTLIKDFDSSK--ENGFLVFFSDHGEDVYD 467
Cdd:COG1368  394 SNHGPYT--LPEED-----------KKIPDYGKTTLNNYLNAVRYADQALGEFIEKLKKSGwyDNTIFVIYGDHGPRSPG 460

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 468 TPPHKMLGRSegkpskviYNVPFLVWqSPEWLNTHQFDlndkttRPFSTMDFIYAWSDLAGLNYTGFES-QKSLFNNEFK 546
Cdd:COG1368  461 KTDYENPLER--------YRVPLLIY-SPGLKKPKVID------TVGSQIDIAPTLLDLLGIDYPSYYAfGRDLLSPDTD 525


                 .
gi 757599193 547 P 547
Cdd:COG1368  526 P 526
PRK11560 PRK11560
kdo(2)-lipid A phosphoethanolamine 7''-transferase;
208-499 7.88e-16

kdo(2)-lipid A phosphoethanolamine 7''-transferase;


Pssm-ID: 183198 [Multi-domain]  Cd Length: 558  Bit Score: 80.47  E-value: 7.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 208 ANMEELIRDNSKIPPLENF--VDANGNTPRTFVLVIGESTSRDRMSLYGYTRPTTPELDElardyPTNLSVFndvvtsRP 285
Cdd:PRK11560 219 AQVDESSDNNSLLNPAKKFtyQAPKGVDDTYVVFIIGETTRWDHMGILGYERNTTPKLAQ-----EKNLAAF------RG 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 286 Y---TIEALQQILTF----ATQTEPELFNSRPSIMNMMKQAGFKTFWITNQQTMTerntlltaFSRQTDKQYYLNNDMAQ 358
Cdd:PRK11560 288 YscdTATKLSLRCMFvregGAEDNPQRTLKEQNVFAVLKQLGFSSELFAMQSEMW--------FYNNTMADNYAYREQIG 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 359 SS-----RIYDDVVFAP-FKEALAD-PAEKKFIVVHLLGTHMRYEFRYPEEKAIFK----GKDDVVPKnlneDEVndYNA 427
Cdd:PRK11560 360 AEprnrgKPVDDMLLVDeMKQSLGRnPDGKHLIILHTKGSHYNYTQRYPRSFARYQpeciGVDSGCSK----AQL--INS 433

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 757599193 428 YDNAQHYNDYVVSTLIkdfDSSKENGFLVFF-SDHGEDVYD------TPphkmlgRSEGKPSKviYNVPFLVWQSPEWL 499
Cdd:PRK11560 434 YDNSVLYVDHFISSVI---DQLRDKKAIVFYaADHGESINErehlhgTP------REMAPPEQ--FRVPMMVWMSDKYL 501
sulfatase_like cd16148
uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from ...
 234-493 3.87e-14

uncharacterized sulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293767 [Multi-domain]  Cd Length: 271  Bit Score: 72.97  E-value: 3.87e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 234 PRTFVLVIgESTSRDRMSLYGYTRPTTPELDELARDyptnlSV-FNDVVTSRPYTIEALQQILT----FATQTEPELFN- 307
Cdd:cd16148    1 MNVILIVI-DSLRADHLGCYGYDRVTTPNLDRLAAE-----GVvFDNHYSGSNPTLPSRFSLFTglypFYHGVWGGPLEp 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 308 SRPSIMNMMKQAGFKTFWITNQQTMTERNTLLTAFSRqTDKQYYLNNDMAQSSRIYDDVVFAPFKEALADPAEKK--FIV 385
Cdd:cd16148   75 DDPTLAEILRKAGYYTAAVSSNPHLFGGPGFDRGFDT-FEDFRGQEGDPGEEGDERAERVTDRALEWLDRNADDDpfFLF 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 386 VHLLGTHMRYefrypeekaifkgkddvvpknlnedevndynAYDNAQHYNDYVVSTLIKDFDSSK--ENGFLVFFSDHGE 463
Cdd:cd16148  154 LHYFDPHEPY-------------------------------LYDAEVRYVDEQIGRLLDKLKELGllEDTLVIVTSDHGE 202

                        250       260       270
                 ....*....|....*....|....*....|
gi 757599193 464 DVYDtppHKMLGRSEGKPSKVIYNVPFLVW 493
Cdd:cd16148  203 EFGE---HGLYWGHGSNLYDEQLHVPLIIR 229
PRK11598 PRK11598
putative metal dependent hydrolase; Provisional
 9-508 7.72e-14

putative metal dependent hydrolase; Provisional


Pssm-ID: 183224 [Multi-domain]  Cd Length: 545  Bit Score: 74.33  E-value: 7.72e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193   9 RFSWISLFWLLIYFWYFSslLQLYVLVTGQSNSI----GLRDSLLYSSlwlIPALLFpKKIKLVAGLIgIVLWLSSVV-- 82
Cdd:PRK11598   7 RPSLNLLTFLLLAAFYIT--LCLNIAFYKQVLQLlpldSLHNVLVFAS---MPVVAF-SVINIVFTLL-SFPWLRRPLac 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193  83 -------ALAYFVV-YGHQISQSVMFVMFETNTNEAGEFLK-QYFSFKVVGVILAytvVAIFLWTRLKPVTLPKSGRIGI 153
Cdd:PRK11598  80 lfilvgaAAQYFMMtYGIVIDRSMIQNIFETTPAESFALMTpQMLLWLGLSGVLP---ALIACWIKIRPATPRWRSVLFR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 154 SLLILIILFGipyynkgikqdrpIANVASYV----------NSKLAYA-APWQFVSGYLLYKNQ--LANMEeLIR---DN 217
Cdd:PRK11598 157 LANILVSVLL-------------ILLVAALFykdyaslfrnNKELVKSlTPSNSIVASWSWYSHqrLANLP-LVRigeDA 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 218 SKIPPLenfvdANGNTPRTFVLVIGESTSRDRMSLYGYTRPTTPeldELARD----YPTNLSVFNDVVTSRPYTIEALQQ 293
Cdd:PRK11598 223 HKNPLM-----QNQKRKNLTILVVGETSRAENFSLGGYPRETNP---RLAKDnviyFPHTTSCGTATAVSVPCMFSNMPR 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 294 iltfaTQTEPELFNSRPSIMNMMKQAGFKTFWITN------------QQTMTERNTlltafsrqtdkqyylnNDMAQSSR 361
Cdd:PRK11598 295 -----KHYDEELAHHQEGLLDIIQRAGINVLWNDNdggckgacdrvpHQDVTALNL----------------PGQCIDGE 353

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 362 IYDDVVFAPFKEALADPAEKKFIVVHLLGTH-MRYEFRYPEEKAIFKGKDDVvpknlNEDEVNDY----NAYDNAQHYND 436
Cdd:PRK11598 354 CYDEVLFHGLENYINNLQGDGVIVLHTIGSHgPTYYNRYPPQFRKFTPTCDT-----NEIQTCTQqqlvNTYDNTILYVD 428

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 437 YVVSTLIKDFDS--SKENGFLVFFSDHGED-----VY--DTPphKMLGRSEGKpskviyNVPFLVWQSPEWlnTHQFDLN 507
Cdd:PRK11598 429 YIVDKAINLLKQhqDKFNTSLVYLSDHGESlgengIYlhGLP--YAIAPDQQT------HVPMLLWLSPDY--QKRYGVD 498


                 .
gi 757599193 508 D 508
Cdd:PRK11598 499 Q 499
LTA_synthase cd16015
Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer ...
 235-519 2.62e-13

Lipoteichoic acid synthase like; Lipoteichoic acid (LTA) is an important cell wall polymer found in Gram-positive bacteria. It may contain long chains of ribitol or glycerol phosphate. LTA synthase catalyzes the reaction to extend the polymer by the repeated addition of glycerolphosphate (GroP) subunits to the end of the growing chain.


Pssm-ID: 293739 [Multi-domain]  Cd Length: 283  Bit Score: 70.40  E-value: 2.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 235 RTFVLVIGESTSRDRMSLYGYTRPTTPELDELARDyptNLSvFNDVVTS--RPYTIEALQQILT-------FATQTEPEL 305
Cdd:cd16015    1 PNVIVILLESFSDPYIDKDVGGEDLTPNLNKLAKE---GLY-FGNFYSPgfGGGTANGEFEVLTglpplplGSGSYTLYK 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 306 FNSRPSIMNMMKQAGFKT-FWITNQQTMTERNTLLTA--FSRQTDKQYYLNNDMAQSSR-IYDDVVFAPFKEALADPAEK 381
Cdd:cd16015   77 LNPLPSLPSILKEQGYETiFIHGGDASFYNRDSVYPNlgFDEFYDLEDFPDDEKETNGWgVSDESLFDQALEELEELKKK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 382 K-FIVVHLLGTHMRYEfrYPEEKAIFKGKDDVVPKNLNEdevndynaYDNAQHYNDYVVSTLIKDFDSSK--ENGFLVFF 458
Cdd:cd16015  157 PfFIFLVTMSNHGPYD--LPEEKKDEPLKVEEDKTELEN--------YLNAIHYTDKALGEFIEKLKKSGlyENTIIVIY 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 757599193 459 SDHGedvydtPPHKMLGRSEGKPSKVIYNVPFLVWqSPEWLNthqfdlNDKTTRPFSTMDF 519
Cdd:cd16015  227 GDHL------PSLGSDYDETDEDPLDLYRTPLLIY-SPGLKK------PKKIDRVGSQIDI 274
SGSH cd16027
N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) ...
 237-462 8.00e-06

N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase); N-sulfoglucosamine sulfohydrolase (SGSH) belongs to the sulfatase family and catalyses the cleavage of N-linked sulfate groups from the GAGs heparin sulfate and heparin. The active site is characterized by the amino-acid sequence motif C(X)PSR that is highly conserved among most sulfatases. The cysteine residue is post-translationally converted to a formylglycine (FGly) residue, which is crucial for the catalytic process. Loss of function of SGSH results a disease called mucopolysaccharidosis type IIIA (Sanfilippo A syndrome), a fatal childhood-onset neurodegenerative disease with mild facial, visceral and skeletal abnormalities.


Pssm-ID: 293751 [Multi-domain]  Cd Length: 373  Bit Score: 48.27  E-value: 8.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 237 FVLVIGESTSRDrMSLYGYTRPTTPELDELARDyptnlSV-FNDVVT-------SR--------PYTIEALQQiltfaTQ 300
Cdd:cd16027    3 ILWIIADDLSPD-LGGYGGNVVKTPNLDRLAAE-----GVrFTNAFTtapvcspSRsalltglyPHQNGAHGL-----RS 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 301 TEPELFNSRPSIMNMMKQAGFKTFwitnqqtmterNTLLTAFSRQTDKQYYLNNDMAQSSRIYDDVVFAPFKEALADPAE 380
Cdd:cd16027   72 RGFPLPDGVKTLPELLREAGYYTG-----------LIGKTHYNPDAVFPFDDEMRGPDDGGRNAWDYASNAADFLNRAKK 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 381 KK--FIVVHLLGTHMRYEFrYPEEKAIFKGKDDVVPKNLNEDEV--NDYnaydnAQHYN-----DYVVSTLIKDFDSSK- 450
Cdd:cd16027  141 GQpfFLWFGFHDPHRPYPP-GDGEEPGYDPEKVKVPPYLPDTPEvrEDL-----ADYYDeierlDQQVGEILDELEEDGl 214

                        250
                 ....*....|...
gi 757599193 451 -ENGFLVFFSDHG 462
Cdd:cd16027  215 lDNTIVIFTSDHG 227
AslA COG3119
Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];
248-566 4.02e-05

Arylsulfatase A or related enzyme, AlkP superfamily [Inorganic ion transport and metabolism];


Pssm-ID: 442353 [Multi-domain]  Cd Length: 393  Bit Score: 46.02  E-value: 4.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 248 DRMSLYGYTRPTTPELDELARDyptnlSV-FNDVVT-------SR--------PYTIealqQILTFATQTEPELFNSRPS 311
Cdd:COG3119   37 GDLGCYGNPLIKTPNIDRLAAE-----GVrFTNAYVtspvcspSRaslltgryPHRT----GVTDNGEGYNGGLPPDEPT 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 312 IMNMMKQAGFKTFWIT-NQQTMTErntLLTAFSRQtdkqyYLNnDMAQSSRiyddvvfaPFkealadpaekkFIVVHLLG 390
Cdd:COG3119  108 LAELLKEAGYRTALFGkWHLYLTD---LLTDKAID-----FLE-RQADKDK--------PF-----------FLYLAFNA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 391 THMRYEFRyPEEKAIFKGKDDVVPKNLNEDEVNDYNAYDNAQHYNDYVVST------LIKDFDSSK--ENGFLVFFSDHG 462
Cdd:COG3119  160 PHAPYQAP-EEYLDKYDGKDIPLPPNLAPRDLTEEELRRARAAYAAMIEEVddqvgrLLDALEELGlaDNTIVVFTSDNG 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193 463 EDVYDtppHKMLGR----SEGkpskvIYNVPFLVWQsPEWLNTHQfdlndKTTRPFSTMDfIYAW-SDLAGLNYT----G 533
Cdd:COG3119  239 PSLGE---HGLRGGkgtlYEG-----GIRVPLIVRW-PGKIKAGS-----VSDALVSLID-LLPTlLDLAGVPIPedldG 303

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 757599193 534 fESQKSLFNNEfKPQPR---YIGDPENKSSLMLYDD 566
Cdd:COG3119  304 -RSLLPLLTGE-KAEWRdylYWEYPRGGGNRAIRTG 337
EptA_B_N pfam08019
Phosphoethanolamine transferase EptA/EptB; This entry represents a domain found in a group of ...
 49-148 1.96e-03

Phosphoethanolamine transferase EptA/EptB; This entry represents a domain found in a group of bacterial phosphoethanolamine transferases, including eptA from Helicobacter pylori and eptB from Escherichia coli EC:2.7.8.42. This domain is found immediately N-terminal to the sulphatase domain in many sulphatases.


Pssm-ID: 429788 [Multi-domain]  Cd Length: 151  Bit Score: 39.04  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 757599193   49 LYSSLWLIPALL-FPKKIKLVAGLigiVLWLSSVVAlaYFVV-YGHQISQSVMFVMFETNTNEAGEflkqYFSFKVVGVI 126
Cdd:pfam08019   1 LFAALNLLLSLLsWRYLLKPLLIL---LLLLSAAAS--YFMDtYGVVIDRDMIQNVLETDVAEASD----LLSPKLLLYL 71

                          90       100
                  ....*....|....*....|....
gi 757599193  127 LAYTVVAIFL--WTRLKPVTLPKS 148
Cdd:pfam08019  72 LLLGVLPALLlwRVRIRYRPWLRE 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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