|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
11-411 |
2.70e-84 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 262.12 E-value: 2.70e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 11 WLYIMPIIFITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWG 90
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVA-APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 91 ACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREM 170
Cdd:cd17319 80 LFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 171 FIIEGVPAIIWAFCWWVLVkdkpeqvkwladdekaalkaqlekeqegikavrnygeafrsRNVILLCMQYFAWSIGVYGF 250
Cdd:cd17319 160 FIIEGLLGLLLAVLWWFYL-----------------------------------------RQVWGLALGYFGINYALYGL 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 251 VLWLPSIIRSGGaNLGMVEVGWLSSVPYLAATIAMILASWASDKL--QNRKLFVWPLLLIAAFAFIGSWAVGanHFWISY 328
Cdd:cd17319 199 LTWLPTYLKQAR-GFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTT--SPVVAV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 329 TLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLT 408
Cdd:cd17319 276 ILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
...
gi 755041493 409 LIV 411
Cdd:cd17319 356 LLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
20-411 |
1.87e-70 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 227.99 E-value: 1.87e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 20 ITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVV 99
Cdd:TIGR00893 1 LVTVINYLDRANLSFA-APMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 100 NNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAI 179
Cdd:TIGR00893 80 GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 180 IWAFCWWVLVKDKPEQVKWLADDEKAALKAQLEKEQEGIKAVRN----YGEAFRSRNVILLCMQYFAWSIGVYGFVLWLP 255
Cdd:TIGR00893 160 IWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGPSTPkkyqIKELLKDRRVWGLALGQFLVNIGLGFFLTWFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 256 SIIRSGGAnLGMVEVGWLSSVPYLAATIAMILASWASDKLQNR--KLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLVI 333
Cdd:TIGR00893 240 TYLVQERG-LSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRgkSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALAL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 334 AGAAMYAPY--GPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTLIV 411
Cdd:TIGR00893 319 VALGFFGLGagAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALALIGALSYLLL 398
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-413 |
4.46e-62 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 204.72 E-value: 4.46e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 9 KRWLYIMPIIFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLIL 88
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPP-LQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 89 WGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWR 168
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 169 EMFIIEGVPAIIWAFCwwvlvkdkpeqvkwladdekaalkaqlekeqegikavrnygeafrsrNVILLCMQYFAWSIGVY 248
Cdd:COG2271 165 AAFLILGLPGLLLALL-----------------------------------------------RFWLLALAYFLVYFALY 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 249 GFVLWLPSIIRSGGaNLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKlfVWPLLLIAAFAFIGSWAVG-ANHFWIS 327
Cdd:COG2271 198 GFLTWLPTYLVEVR-GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR--KLVLAIGLLLAALALLLLAlLPSPALA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 328 YTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGsPSASYIFMGVALFVSVWL 407
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALL 353
|
....*.
gi 755041493 408 TLIVKP 413
Cdd:COG2271 354 ALLLLR 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
8-421 |
2.34e-53 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 182.77 E-value: 2.34e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 8 AKRWLyIMPIIFITYSLAYLDRANFSFAsAAGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLI 87
Cdd:COG2223 1 SGRWR-VLLLATLAFFLAFGVWYLWSVL-APPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 88 LWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGW 167
Cdd:COG2223 79 LLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 168 REMFIIEGVPAIIWAFCWWVLVKDKPEQVkwlADDEKAALKAQLekeqegikavrnygEAFRSRNVILLCMQYFAWSIGV 247
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLFLRDPPAGA---AAAAKASLRDQL--------------EALRDPRFWLLSLLYFGTFGSF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 248 YGFVLWLPSIIRSgGANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGAnhFWIS 327
Cdd:COG2223 222 IGFSSWLPPYLVD-QFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS--LWLF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 328 YTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWL 407
Cdd:COG2223 299 LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVL 378
|
410
....*....|....
gi 755041493 408 TLIVKPANNQQAPA 421
Cdd:COG2223 379 TLLLYRRPRRAAAA 392
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-338 |
1.30e-42 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 154.71 E-value: 1.30e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 12 LYIMPIIFITYSLAYLDRANFSFASAAGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGA 91
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 92 CASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTvlwmSVVSGYLIQSF------ 165
Cdd:cd17327 84 LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLG----SIFGGLLAYGVfkilgv 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 166 ----GWREMFIIEGVPAIIWAFCWWVLVKDKPEQVKWLADDEKAALKAQLEKEQEG-------IKAVRnygEAFRSRNVI 234
Cdd:cd17327 160 gglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGkgdqkfkWKQIK---EAFKDPRTW 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 235 LLCMQYFAWSIGVYGFVLWLPSIIRSGGANLgmVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFV--WPLLLIAAFA 312
Cdd:cd17327 237 LLFLFFFCSQITNNGISNFLPLILKSLGFYS--LQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAifACVLALVGSI 314
|
330 340
....*....|....*....|....*.
gi 755041493 313 FIGSWAVGANHFWISYTLLVIAGAAM 338
Cdd:cd17327 315 ILLAAPNPPGAYFAAYILGGGSYAGF 340
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-377 |
1.32e-39 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 145.25 E-value: 1.32e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 18 IFITYSLAYLDRANFSFASAAGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTG 97
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 98 VVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVP 177
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 178 AIIWAFCWWVLVKDKPEqvkwladdekaalKAQLEKEQEGIKAVRNYGEAFRSRNVILLCMqYFAWSIGVYGFVLWLPSI 257
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES-------------KRPKPAEEARLSLIVAWKALLRDPVLWLLLA-LLLFGFAFFGLLTYLPLY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 258 IRSggANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAA 337
Cdd:pfam07690 227 QEV--LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFG 304
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 755041493 338 MYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:pfam07690 305 FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-383 |
2.33e-33 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 129.03 E-value: 2.33e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 19 FITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGV 98
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPY-LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 99 VNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFL--------ILGNPVTVLWMSvvsgyliQSFGWREM 170
Cdd:TIGR00881 80 STSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWncshnvggGLLPPLVLFGIA-------ELYSWHWV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 171 FIIEGVPAIIWAFCWWVLVKDKPEQVKWLADDE---KAALKAQLEKEQEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGV 247
Cdd:TIGR00881 153 FIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEmpnEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVR 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 248 YGFVLWLPsIIRSGGANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAA--FAFIGSWAVGANHFW 325
Cdd:TIGR00881 233 TGILDWSP-LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALiiVSLLVYWLNPAANPL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 755041493 326 ISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:TIGR00881 312 MDLICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
40-373 |
1.07e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 120.85 E-value: 1.07e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAV 119
Cdd:COG2814 36 IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAII-WAFCWWVLVKDKPEQVKw 198
Cdd:COG2814 116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAARA- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 199 laddekaalkaqlekeqegiKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSgGANLGMVEVGWLSSVPY 278
Cdd:COG2814 195 --------------------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE-VLGLSASAAGLLLALFG 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 279 LAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWavgANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVA 358
Cdd:COG2814 254 LGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEAR 330
|
330
....*....|....*
gi 755041493 359 GGAMALINSMGALGS 373
Cdd:COG2814 331 GRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-409 |
3.67e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 120.22 E-value: 3.67e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 18 IFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTG 97
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPA-LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 98 VVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQ--SFGWREMFIIEG 175
Cdd:cd06174 80 FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 176 VPAIIWAFCWWVLVKDKPEQvkwladdekaalKAQLEKEQEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLP 255
Cdd:cd06174 160 ALALLAAILLLLVVPDPPES------------ARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 256 SIIRSGGANLGmVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAvgANHFWISYTLLVIAG 335
Cdd:cd06174 228 LFLLDLGGLSV-AVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL--APSLLLLLLLLLLLG 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755041493 336 AAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTL 409
Cdd:cd06174 305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
42-412 |
8.02e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 116.14 E-value: 8.02e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 42 EDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKPEQVKwlad 201
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN---- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 202 dekaalkaqlEKEQEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGaNLGMVEVGWLSSVPYLAA 281
Cdd:cd17325 180 ----------KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG-GLSPAQIGLLFGAQGLAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 282 TIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAiipEMLPRNVAGGA 361
Cdd:cd17325 249 ALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA---DIVPPEGRGTA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 755041493 362 MALINSMGALGSFFGSWFVGYLNgSTGSPSASYIFMGVALFVSVWLTLIVK 412
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLLGGFLY-DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
40-411 |
6.78e-27 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 111.12 E-value: 6.78e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAV 119
Cdd:COG2807 44 IRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 120 MPAMLIYISNWFTKSeRSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKPeqvkwl 199
Cdd:COG2807 124 NVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP------ 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 200 addekaalkaqleKEQEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGanLGMVEVGWLSSVPYL 279
Cdd:COG2807 197 -------------AAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAG--LSAATAGLLLSLFQL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 280 AATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFWISytlLVIAGAAMYAPYGPFFAIIPEMLPR-NVA 358
Cdd:COG2807 262 AGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLW---AVLLGLGQGGLFPLALTLIGLRARTpAEA 338
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 755041493 359 GGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTLIV 411
Cdd:COG2807 339 AALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-405 |
4.30e-25 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 105.38 E-value: 4.30e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 17 IIFITYSLAYLDRANFSFASAA-GINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASL 95
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVlAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 96 TGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRA----NTFLILGNPVTVLWMSVVSGYLIQSFGWREMF 171
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFAlgllQSGWALGALLAALVASLLIPLLSGDWGWRILF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 172 IIEGVPAIIWAFCWwvlvkdkpeqvkwladdekaalkaqlekeqegikavrnygeafrsRNVILLCMQYFAWSIGVYGFV 251
Cdd:cd17316 163 LIGALPALLALLLR---------------------------------------------RRTLLLILLWFFISFGYYGLT 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 252 LWLPSIIRSGGaNLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIgSWAVGANHFWISYTLL 331
Cdd:cd17316 198 TFLPTYLQTVL-GLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALP-LFYLLSGSPTLLLLLL 275
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755041493 332 VIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSV 405
Cdd:cd17316 276 FILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
47-383 |
6.31e-25 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 105.39 E-value: 6.31e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 47 TKGIssLLGAlFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNI--PMLAAIRFILGVVEAAVMPAML 124
Cdd:cd17318 57 TQGI--ILSS-FFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGgyGALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 125 IYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVkdkpeqvkwladdek 204
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 205 aalkaqlekeqegikavrnygeafrsRNVILLCMQYFAWSIGVYGFVLWLPSIIRS-GGANLGmvEVGWLSSVPYLAATI 283
Cdd:cd17318 199 --------------------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDvLHFNIK--SNGFLSSLPYLAMWI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 284 AMILASWASDKLQN---------RKLF-VWPLLLIAAFAFIGSWavGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEML 353
Cdd:cd17318 251 CSIVGGYLADWLRSrgilstttvRKLFtSIGFLGPGVFLIALGY--LGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLA 328
|
330 340 350
....*....|....*....|....*....|
gi 755041493 354 PrNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:cd17318 329 P-NYAGTLMGITNTAATIAGIISPLIVGAI 357
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
36-383 |
1.60e-24 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 104.36 E-value: 1.60e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 36 SAAGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVV 115
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 116 EAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGV-PAIIWAFCWWVL------ 188
Cdd:TIGR00895 119 LGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLpesidf 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 189 -VKDKPEQVKWLADDEKAALKAQLEKEQEGIKAVRNYGEAF--------RSRNVILLCMQYFAWSIGVYGFVLWLPSIIR 259
Cdd:TIGR00895 199 lVSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVfkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLPKLMV 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 260 SGGANLGMVeVGWLSSVpYLAATIAMILASWASDKLQNRKLFVWPlLLIAAFAFIGswAVGANHFWISYTLLVIAGAAMY 339
Cdd:TIGR00895 279 ELGFSLSLA-ATGGALF-NFGGVIGSIIFGWLADRLGPRVTALLL-LLGAVFAVLV--GSTLFSPTLLLLLGAIAGFFVN 353
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 755041493 340 APYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:TIGR00895 354 GGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
16-411 |
1.30e-23 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 101.93 E-value: 1.30e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 16 PIIFITYSLAYLDRanFSFASAAG-INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACAS 94
Cdd:cd17328 2 AVLFLINLLNYMDR--FTIAGVLPdIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 95 LTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSF-GWREMFII 173
Cdd:cd17328 80 LSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 174 EGVPAIIWAFCWWVLVKDKPEQvkwlADDEKAALKAQLEKEQEGIKAVrnygeaFRSRNVILLCMQYFAWSIGVYGFVLW 253
Cdd:cd17328 160 TGVLGVLLAILLLLFVREPPRG----AAEGGVMAKSTATSFLADLKAL------AKNPSFILSTLGFTAVSFVTGALAFW 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 254 LPSIIRSGGANLGMVEV---GWLSSVPYLAATIAMILASWASDKLQNRKLFVWPL-----LLIAAFAFIGSWAVGANHFW 325
Cdd:cd17328 230 APTFFLRAFGVGDLSSAdvgLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLvcavgLLAAAPFLFLALVLALSNLL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 326 ISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMG-ALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVS 404
Cdd:cd17328 310 LAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLShLLGDAGSPYLIGLISDLLRQNKDSPLAEAASLQYA 389
|
....*..
gi 755041493 405 VWLTLIV 411
Cdd:cd17328 390 LLLCSFV 396
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
18-411 |
5.72e-23 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 100.01 E-value: 5.72e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 18 IFITYSLAYLDRANFSFASAaGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTG 97
Cdd:cd17345 8 IFIGYAGYYLVRNNFSLAQP-YLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 98 VVN----NIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFG---WREM 170
Cdd:cd17345 87 FVPsatsSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 171 FIIEGVPAIIWAFCWWVLVKDKPEQV------KWLADDEKAALKAQLEKEQEGIKAVRNYgeAFRSRNVILLCMQYFAWS 244
Cdd:cd17345 167 FIFPAIIAIIVAVIVLFLGKDTPESEglppieEYKGDYPEEADGEEEEQELSAWEIFVKY--VLKNKLLWYIAIANVFVY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 245 IGVYGFVLWLPsIIRSGGANLGMVEVGWLSSVPYLAATIAMILASWASDKL-QNRKLFVWPLLLIAAFAFIGSWAVGANH 323
Cdd:cd17345 245 LVRYGILDWAP-TYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLfKGRRAPTGIIFMILVIVALIVYWLAPNV 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 324 FWIsYTLLVIAGAAMyapYGPFFAI---IPEMLPRNVAGGAMALINSMGAL-GSFFGSWFVGYLNGSTGSpSASYIFMGV 399
Cdd:cd17345 324 LVD-LIALIALGFLI---YGPVMLIglqALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGW-NGGFIVLLA 398
|
410
....*....|..
gi 755041493 400 ALFVSVWLTLIV 411
Cdd:cd17345 399 SCILAIIFLALV 410
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
19-389 |
1.74e-22 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 98.01 E-value: 1.74e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 19 FITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGV 98
Cdd:cd17380 5 FLATCICYADRVNMPIAIVP-MAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 99 V--NNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGV 176
Cdd:cd17380 84 LaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 177 PAIIWAFCWWVLVKdkpeqvkwladdekaalkaqlekeqegikavrnygeAFRSRNVILLCMQYfawsiGVYGFVLWLPS 256
Cdd:cd17380 164 LGLLWALVWLIYLP------------------------------------PVWAIIVAHFCMNW-----GFYILLSWLPT 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 257 IIRSGGANLGmvEVGWLSSVPYLAATIAMILASWASDKLQN--------RKLF-VWPLLLIAAFAFIGSWavgANHFWIS 327
Cdd:cd17380 203 YFHEVLVPLA--KGWVFNVVPWLVMFPSSNVAGWLADHLISrgwtvtsvRKLMqSIGFLGPALFLLLLSH---TDSFSLA 277
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755041493 328 YTLLVIAGAAMYAPYGPFFAIIPEMLPRNvAGGAMALINSMGALGSFFGSWFVGYLNGSTGS 389
Cdd:cd17380 278 LLCMSVALGLSAFSSSGVLVNHQDIAPNY-AGIVFGISNTAGTIPGIVGVYLTGYILEATGS 338
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
40-404 |
2.55e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 97.62 E-value: 2.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAV 119
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKPEQVKwl 199
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKP-- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 200 addekaalkaqlekeqEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANLGMVEVGWLSSVpYL 279
Cdd:cd17324 183 ----------------GSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLF-GV 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 280 AATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWavgANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAG 359
Cdd:cd17324 246 AGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLL---GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGL 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 755041493 360 GA---MALINSMGALGSFFGSWFVGYLnGSTGSPSASYIFMGVALFVS 404
Cdd:cd17324 323 ASslyLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLA 369
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
37-411 |
1.23e-21 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 95.34 E-value: 1.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 37 AAGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVE 116
Cdd:cd17365 22 APALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 117 AAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAfcwwVLVkdkpeqv 196
Cdd:cd17365 102 GAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILL----PLL------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 197 kwladdekaalkaqlekeqegikavrnygeafrsRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANLGmvEVGWLSSV 276
Cdd:cd17365 171 ----------------------------------RGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLS--QALTITLL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 277 PYLAATIAMILASWASDKLQNRKLFVWPLLLiaAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRN 356
Cdd:cd17365 215 LNIGGVIGSLLLGWLADRFGPKRVLALFFAL--GAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTE 292
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 755041493 357 VAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTLIV 411
Cdd:cd17365 293 VRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLL 347
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
10-402 |
1.47e-20 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 92.34 E-value: 1.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 10 RWlYIMPIIFITYSLAYLDRANFSFASAaGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILW 89
Cdd:cd17312 1 RW-RIFLGVFLGYAAYYVCRKNFSVAKP-PIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 90 GACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWRE 169
Cdd:cd17312 79 ALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 170 MFIIEGVPAIIWAFCWWVLVKDKPeqvkwladdekaalkaqlekeqegikavrnygeafrsRNVILLCMQYFAWSIGVYG 249
Cdd:cd17312 159 AFLVPGIVGLVVAIILFFFLRDSP-------------------------------------PYVWVLSLAYAFVYIVRYA 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 250 FVLWLPSIIrSGGANLGMVEVGWLSSVPYLAATIAMILASWASDKL--QNRKLFVWPLLLIAAFAFIGSWAVGANhFWIS 327
Cdd:cd17312 202 CLDWGPLYL-YEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHN-KLLS 279
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755041493 328 YTLLVIAGAAMYAPYGPFFAIIPEMLPR-NVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALF 402
Cdd:cd17312 280 IVLLFLIGFFVGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALL 355
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
42-418 |
1.54e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 92.61 E-value: 1.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 42 EDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMP 121
Cdd:COG0738 36 DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 122 AMLIYISNWFTKSERSRANTFLILgNPVTVLWMSVVSGYLIQ---SFGWREMFIIEGVPAIIWAFCWWvlvkdkpeqvkw 198
Cdd:COG0738 116 AANPYVAALGPETAASRLNLLHAF-FSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALLFL------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 199 laddeKAALKAQLEKEQEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGaNLGMVEVGWLSSVPY 278
Cdd:COG0738 183 -----RSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL-GLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 279 LAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIgswAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNvA 358
Cdd:COG0738 257 GGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLL---ALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKR-T 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 359 GGAMALINSMGALGSFFGSWFVGYLNGSTGsPSASYIFMGVALFVSVWLTLIVKPANNQQ 418
Cdd:COG0738 333 AAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
35-409 |
2.65e-19 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 88.83 E-value: 2.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 35 ASAAGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGV 114
Cdd:cd17475 17 ALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 115 VEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKPE 194
Cdd:cd17475 97 GYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 195 qvkwladdeKAALKAQLEKEQEGIKAVRnygeafRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGAnLGMVEVGWLS 274
Cdd:cd17475 177 ---------ASAATESASTLLRSLKEVL------RNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLG-LSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 275 SVPYLAATIAMILASWASDKL--QNRKLFVWPLLLIAAFAFIG-SWAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPE 351
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVlSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 755041493 352 MLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTL 409
Cdd:cd17475 321 SAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
40-408 |
2.61e-17 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 83.07 E-value: 2.61e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGA-CASLTGVVNNIPMLAAIRFILGVVEAA 118
Cdd:cd17341 25 IRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIpLLALALAVSSYWGLLVLGFLLGFAGAN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 119 VMPAMlIYISNWFTKSERSRANTFLI----LGNPVTVLWMSVVSGYLIQ---SFGWREMFIIEGVPAIIWAFCWWVLVKD 191
Cdd:cd17341 105 FASGQ-PWASFWFPKEKIGGAAGGIAgagnMGVAVSQLLAPLIAGAIVFdggFVGWRNAFFVPGILLAIAAVLVLLFGDD 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 192 KPEQVKWLADDEKAALKAqlekeqegikavrnygeaFRSRNVILLCMQYFAwSIGVY-GFVLWLPSIIRSGgANLGMVEV 270
Cdd:cd17341 184 LPTGKASALEFLKVQLAV------------------LKNYRTWILSLLYGV-TFGSFvGFSNVLPTYFKTR-FGLPLVTA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 271 GWLSSVPYLAATIAMILASWASDKLQNRK--LFVWPLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAI 348
Cdd:cd17341 244 GILAALFPLAGALARPAGGWLSDRFGGRRrlWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSVFRM 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 349 IPEMLPRNVaGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLT 408
Cdd:cd17341 324 VPFIFRREL-GAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
58-405 |
1.31e-16 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 81.71 E-value: 1.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 58 FFLGYFFFQIPGALYAERRSVRKLI----FIC-----LILWGACASLTGVVnnipmlaAIRFILGVVEAAVMPAMLIYIS 128
Cdd:TIGR00894 85 HFYGQIIIQIPVGYLAGKYVFKWSIgigmFLSsvisiVIPWAAGGGIALVV-------FCRVIQGLAQGSVSPATHKIIV 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 129 NWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSF-GWREMFIIEGVPAIIWAFCWWVLVKDKPEQVKWLADDEKAAL 207
Cdd:TIGR00894 158 KWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYI 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 208 KAQLEKEQEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSggaNLGM--VEVGWLSSVPYLAATIAM 285
Cdd:TIGR00894 238 NSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISW---VLRVsgKENGLLSSLPYLFAWLCS 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 286 ILASWASDKLQNRKLFVwpllLIAA---FAFIGSWAVGA---------NHFWISYTLLVIAGAAMYAPYGPFFAIIPEML 353
Cdd:TIGR00894 315 IFAGYLADFLKSSKTLS----LTAArkiFNGIGGLGPGIfayalpylsAAFYLTIIILTLANAVSSGPLAGVLINSLDLA 390
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 755041493 354 PRnVAGGAMALINSMGALGSFFGSWFVGyLNGSTGSPSASYIFMGVALFVSV 405
Cdd:TIGR00894 391 PR-FLGFIKGITGLPGFIGGLIASTLAG-NILSQDSKNVWLIVFLIMAFVNI 440
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
52-410 |
4.33e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 79.58 E-value: 4.33e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 52 SLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVV-----NNIPMLAAIRFILGVVEAAVMPAMLIY 126
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLallgsLSLWLLLVLAFLLGIASAFFGPARQAL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 127 ISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKPEQVKwladdekaa 206
Cdd:cd06173 117 LPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPG--------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 207 lkaqlEKEQEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANLGMVEVGWLSSVPYLAATIAMI 286
Cdd:cd06173 188 -----ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGAL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 287 LASWASDKLQNRKLFVWPLLLIAAFAFIGSWAvgaNHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALIN 366
Cdd:cd06173 263 LLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN 339
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 755041493 367 SMGALGSFFGSWFVGYLnGSTGSPSASYIFMGVALFVSVWLTLI 410
Cdd:cd06173 340 ALNSGAMPLGALLAGLL-ADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
73-411 |
6.94e-16 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 78.77 E-value: 6.94e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 73 AERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRA----NTFLILGNP 148
Cdd:cd17473 59 ADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMlglqSAAMSLGGV 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 149 VTVLwmsvVSGYLIqSFGWREMFIIEGVPAIIWAFCWWVLvkdkPEqvkwladdekaalKAQLEKEQEGIKAVRNygEAF 228
Cdd:cd17473 139 VFLL----LGGALA-EIGWRAPFLVYLLALPVLILVLLFL----PE-------------PARKSKSAASPGAATA--AAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 229 RSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGaNLGMVEVGWLSSVpylaATIAMILASWASDKLQNRKLFVWPLLLI 308
Cdd:cd17473 195 PWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERG-GGSAALIGLALAI----ASLAGAIGALLFGRLKRRLGKRRLLAIG 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 309 AAFafigsWAVGANHFWISYTLLVIAGAAMYAPYG-----PF-FAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGY 382
Cdd:cd17473 270 FAL-----MALGFLLLALASGLWVVLLGAILAGLGfglllPTlNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGP 344
|
330 340
....*....|....*....|....*....
gi 755041493 383 LNGSTGSPSASYIFMGVALFVSVWLTLIV 411
Cdd:cd17473 345 LVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-410 |
1.05e-15 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 78.11 E-value: 1.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 19 FITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGV 98
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPA-LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 99 VNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQ----SFGWREMFIIE 174
Cdd:cd17371 84 AQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLFLLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 175 GVPAIIwafCWWV--LVKDKPEqvkwladdekaALKAQLEKEQEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFVL 252
Cdd:cd17371 164 ALPALL---VLFIrrFVKEPPQ-----------WQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGIT 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 253 -WLPSIIRsGGANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFvwpllliaAFAFIGSWAVGANHFWI--SYT 329
Cdd:cd17371 230 tWLPSYLT-GERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNF--------ALFALGSAISILLYFFLplSPT 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 330 LLVIAGAA----MYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSV 405
Cdd:cd17371 301 LILILGFPlgffASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGL 380
|
....*
gi 755041493 406 WLTLI 410
Cdd:cd17371 381 VLALL 385
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
42-409 |
4.62e-15 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 76.06 E-value: 4.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 42 EDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17478 24 AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 122 AMLIYISNwFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKPEQVKwlad 201
Cdd:cd17478 104 EGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAK---- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 202 dekaalkaqleKEQEGIKAVRNYGEAFRSrnVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANLgmVEVGWLSSVPYLAA 281
Cdd:cd17478 179 -----------KAAAKSSARSTLKGVWRA--LLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSL--VFAGLLLSLFLFAG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 282 TIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGanhfWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNV---A 358
Cdd:cd17478 244 AIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG----IWSYILLVLAGFLLFASFPVTVVLAQELLPGNVglaS 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 755041493 359 GGAMALINSMGALgsffGSWFVGYLnGSTGSPSASYIFMGVALFVSVWLTL 409
Cdd:cd17478 320 GLMMGLSFGLGGI----GAPVLGAL-ADAFGLESVLLILALLPLLGALLAF 365
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-291 |
3.45e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 72.92 E-value: 3.45e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 1 MKSSTNAAKRWLY-IMPIIFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVR 79
Cdd:COG0477 1 MSSTDAAPTRRRRrALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 80 KLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSG 159
Cdd:COG0477 80 RVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 160 YLIQSFGWREMFIIEGVPAIIwAFCWWVLVKDKPEQVKWLADDEKAALKAQLEKEQEGIKAVRNYGEAFRSRNVILLCMQ 239
Cdd:COG0477 160 LLVAALGWRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 755041493 240 YFAWSIGVYGFVLWLPSIIRSGGANLGMVEVGWLSSVPYLAATIAMILASWA 291
Cdd:COG0477 239 LLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLL 290
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
40-404 |
7.41e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 66.53 E-value: 7.41e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAV 119
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 120 MPAMLI-YISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKPEqvkw 198
Cdd:cd17355 109 LAAVAFaTVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPA---- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 199 laddEKAALKAQLEKEQEGIKAVRnygEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGanLGMVEVGWLSSVPY 278
Cdd:cd17355 185 ----DLALRAYDDASPASPGSTLK---EALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRG--ISPAAAAVALALIG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 279 LAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLViaGAAMYAPYGPFFAIIPEMLPRNVA 358
Cdd:cd17355 256 LFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALF--GLGWGATVPLTAALAARYFGARSY 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 755041493 359 GGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVS 404
Cdd:cd17355 334 GTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIA 379
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
40-411 |
1.14e-11 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 66.11 E-value: 1.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAV 119
Cdd:PRK12307 44 IKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGE 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTvlwmSVVSGYLIQSF----GWREMFIIEGVPAIIWAFcwwvLVKDKPEQ 195
Cdd:PRK12307 124 YACASTYAVESWPKHLKSKASAFLVSGFGIG----NIIAAYFMPSFaeayGWRAAFFVGLLPVLLVIY----IRARAPES 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 196 VKWLAD---DEKAALKAQLEKEQEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFvlwLPSIIRSGGANLGMVEVgw 272
Cdd:PRK12307 196 KEWEEAklsGKGKHSQSAWSVFSLSMKGLFNRAQFPLTLCVFIVLFSIFGANWPIFGL---LPTYLAGEGFDTGVVSN-- 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 273 LSSVPYLAATIAMILASWASDKLQNRKLFVwpLLLIAAFAFI---------GSWAVGANHFWISYTLLVIAGAAmyapyg 343
Cdd:PRK12307 271 LMTAAAFGTVLGNIVWGLCADRIGLKKTFS--IGLLMSFLFIfplfripqdNYLLLGACLFGLMATNVGVGGLV------ 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 344 PFFaiIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGspsasyifMGVALF--VSVWLTLIV 411
Cdd:PRK12307 343 PKF--LYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMG--------LGAALTfiVAFWTATIL 402
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
40-408 |
6.29e-11 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 63.75 E-value: 6.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAV 119
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAII-WAFCWWVLVKDKPEqvkw 198
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLlLLLVLLFLPETLPE---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 199 laDDEKAALKAQLekeqegikavRNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPsIIRSGGANLGMVEVGWLSSVPY 278
Cdd:cd17320 181 --EKRKPLLSSLL----------RAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAP-FIYIEQLGLSPAQFGLLFALNA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 279 LAATIAMILASWASDKLQNRKLFVW--PLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRn 356
Cdd:cd17320 248 IALILGSLLNGRLVRRFGPRRLLRLglLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPH- 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 755041493 357 VAGGAMALINSMGALGSFFGSWFVGYL-NGSTGSPSASYIFMGVALFVSVWLT 408
Cdd:cd17320 327 VAGTASALLGFLQFLIGALAGALVGLLpNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
40-411 |
7.46e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 63.36 E-value: 7.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAV 119
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 120 MPAMLIYISNWFTKSERSRAntfliLGNPVTVLWMSVVSGYLIQSF----GWREMFIIEGVPAIIWAFCWWVLVKDKPEQ 195
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKA-----MGLYEAALGLGIAVGPLLGGLlaaiSWRYPFFLLAALIPVAFLAILFLLPEPKEK 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 196 VKWLADDEKAALKAqlekeqegikavrnygeAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSgGANLGMVEVGWLSS 275
Cdd:cd17474 180 AKSSSATKLRDLKK-----------------ALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLEL-LYGISPIIIGLLFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 276 VPYLAATIAmilASWASDKLQNRKLFVWplLLIAAFAFIGSWAVGANhFWISYTLLVIAGAAMYAPYGPFFAIIPEML-- 353
Cdd:cd17474 242 GWSVLLALG---SLFVGRLLKKRFGARR--ILVIGLLLYALSLLLLG-FVPSLALLLIAIVLFGLGLGLNLPLLTTLVte 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 354 --PRNVAGGAMALINSMGALGSFFGSWFVGYLnGSTGSPSASYIFMGVALFVSVWLTLIV 411
Cdd:cd17474 316 laPEEERGTASSLYNFVRFLGQAVGPLLFGLL-LEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
79-403 |
9.91e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 63.38 E-value: 9.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 79 RKLIFICLILWGACASLT------GVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKS-ERSRANTFLILGNPVTV 151
Cdd:COG2211 81 RPWILIGAIPLALSFVLLftapdlSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYeERTRLSSWRFAFAGLGG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 152 LWMSVVSGYLIQSF------GWREMFIIEGVPAIIWAFCWWVLVKDKPEqvkwladdekaalkaqleKEQEGIKAVRNYG 225
Cdd:COG2211 161 LLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPV------------------PEEEKVSLKESLK 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 226 EAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSggaNLGMVE--VGWLSSVPYLAATIAMILASWASDKLQNRKLFVW 303
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKY---VLGLSAalVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFII 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 304 pLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLP-------RNVAGGAMALINSMGALGSFFG 376
Cdd:COG2211 300 -GLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALA 378
|
330 340 350
....*....|....*....|....*....|..
gi 755041493 377 SWFVGYLNGSTG-----SPSASYIFMGVALFV 403
Cdd:COG2211 379 GALAGLLLALFGyvagaAQSPSALTGIRLLFF 410
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
12-378 |
5.93e-10 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 60.88 E-value: 5.93e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 12 LYIMPIIFITYSLAYLDRANFSFASAAGINeDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGA 91
Cdd:PRK11663 22 RHILITMYLGYALFYFTRKSFNAAMPEMLA-DLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 92 CASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSER----SRANTFLILGNPVTVLwmsvVSGYLIQSFGW 167
Cdd:PRK11663 101 INILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERggwwAIWNTAHNVGGALIPL----VVGAIALHYGW 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 168 REMFIIEGVPAIIWAF--CWwvLVKDKPEQV------KWLADdekaALKAQLEKEQEGI---KAVRNYgeAFRSRNVILL 236
Cdd:PRK11663 177 RYGMMIAGIIAIVVGLflCW--RLRDKPQAMglpsvgEWRHD----ALELAQQQEGAGLsrkEILTKY--VLLNPYIWLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 237 CMQYFAwsigVYgfvlwlpsIIRSG---GANLGMVEVGWLSSVPYLAAT--------IAMILASWASDKL--QNRKlfvw 303
Cdd:PRK11663 249 SFSYVL----VY--------VVRAAindWGNLYMSETLGVDLVTANSAVsmfelggfIGALVAGWGSDKLfnGNRG---- 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 304 PLLLIAA---FAFIGS-WAVGANHFWISYTLLVIAGaamyapygpFFAIIPEML---------PRNVAGGAMALINSMGA 370
Cdd:PRK11663 313 PMNLIFAagiLLSVGSlWLMPFASYVMQAACFFTIG---------FFVFGPQMLigmaaaecsHKEAAGAATGFVGLFAY 383
|
....*...
gi 755041493 371 LGSFFGSW 378
Cdd:PRK11663 384 LGAALSGY 391
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
228-426 |
6.60e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 60.37 E-value: 6.60e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 228 FRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANLGMVevGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLL 307
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQA--GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 308 IAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYgpfFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLnGST 387
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAA---LALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL-ADL 160
|
170 180 190
....*....|....*....|....*....|....*....
gi 755041493 388 GSPSASYIFMGVALFVSVWLTLIVKPANNQQAPARMMRA 426
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS 199
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
236-431 |
8.48e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 60.28 E-value: 8.48e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 236 LCMQYFAWSIGVYGFVLWLPSIIRSGGAnlGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIG 315
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGA--SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 316 SWAvgaNHFWISYTLLVIAGAAMyAPYGP-FFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGsPSASY 394
Cdd:cd17325 79 AFA---TSYWQLLLARFLQGLAS-AAVWPaAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPF 153
|
170 180 190
....*....|....*....|....*....|....*..
gi 755041493 395 IFMGVALFVSVWLTLIVKPANNQQAPARMMRAGRPST 431
Cdd:cd17325 154 LVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRS 190
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
64-412 |
9.02e-10 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 59.93 E-value: 9.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 64 FFQIPGALYAERRSVRKL-IFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISnWFTKSERSRANTF 142
Cdd:cd17490 46 LLRIPLGILSDRIGKRKLfIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYAS-YFPPDEAAKAMGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 143 LILGNPVTVLWMSVVSGYLIQSFGWREMF---IIEGVPAIIWAFcwwvlvkdkpeqvkwladdekaALKAQLEKEQEGIK 219
Cdd:cd17490 125 INLVNNLGQLIAFLIGGLIAEHFGMRAPFllaALAGVLGFILSL----------------------FIKEERREKKPVLT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 220 AVRNYGEAFRSRNVIL-----LCMQYFAWSiGVYGFVlwlPSIIRSGGANLGmvEVGWLSSVPYLAATIAMILASW-ASD 293
Cdd:cd17490 183 ELKELLSVLKDKKLLFfsllaILQQMITFS-TTFGFT---PLIAKQLGASSF--QLGLLSIIYLLPNALASLLSGTlFYK 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 294 KLQNRKLFVWPLLLIAAFAFIgswAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGS 373
Cdd:cd17490 257 KLGERNTIIIGFLLLGAYCFL---IPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGM 333
|
330 340 350
....*....|....*....|....*....|....*....
gi 755041493 374 FFGSWFVGYLNGSTGSpSASYIFMGVALFVSVWLTLIVK 412
Cdd:cd17490 334 FLGPVLVGIISEAFGL-QTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
40-411 |
1.22e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 59.55 E-value: 1.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLaairfILGVVEAAV 119
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLL-----FLGYGVLGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 120 MPAMLIYIS------NWFtKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKP 193
Cdd:cd17353 104 IGAGIGYITpvstavKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 194 EqvkwladDEKAALKAQLEKEQEGIKAVRNYGEAFRSRNVILLCMQYF-AWSIGVYGFVLWlpSIIRSGGANLGMVEVGW 272
Cdd:cd17353 183 K-------GWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFlNATAGLMLIGQA--KPIGQEFAGLDAGIAAL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 273 LSSVPYLAATIAMILASWASDKLqNRKLFVWPLLLIAAFAFIGSWAVGANhfwisYTLLVIAGAAMYAPYGPFFAIIPEM 352
Cdd:cd17353 254 AVSILSIFNGGGRPFWGWLSDKI-GRKNTLSIAFLIQGVAMFLLPFIGSV-----AVLFVLGVALIGFCYGGGFALFPAL 327
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755041493 353 LPR----NVAGGAMALINSMGALGSFFGSwFVGYLNGSTGSPSASYIFMGVALFVSVWLTLIV 411
Cdd:cd17353 328 TADffgtKNAGTNYGLLYTAKGVGGLIGP-IIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
42-412 |
1.33e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 59.63 E-value: 1.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 42 EDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd06180 27 AELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSV-VSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKPEQVKWLA 200
Cdd:cd06180 107 FGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLlVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEAS 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 201 DDEKAalkaqlekeqegikavrnygeAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGAnlGMVEVGWLSSVPYLA 280
Cdd:cd06180 187 AAESA---------------------PGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGA--GSLLAGLLWSLFGLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 281 ATIAMILASWASDKLQNRKLFVWPLLliaafafIGSWAVGANHFWISYTLLVIaGAAMYApyGPFFAIIPEMLPR----- 355
Cdd:cd06180 244 AVPSCFLWGALSDRWGTRRALAANLL-------VQAVGVLLPLLSPGPAGLVL-SAVLFG--GTFMAITALVMALarela 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 755041493 356 -NVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTLIVK 412
Cdd:cd06180 314 pPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
42-411 |
1.87e-09 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 59.10 E-value: 1.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 42 EDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPML-AAIRFILGVVEAAVM 120
Cdd:cd17352 31 EEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLyLTYGVLGGLGLGLIY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 121 PAMLIYISNWFTKsERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCwwvlvkdkpeqvkwla 200
Cdd:cd17352 111 SPAIVIVGQYFEK-KRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVC---------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 201 ddekAALkaqlekeqegikavrnyGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANlgMVEVGWLSSVPYLA 280
Cdd:cd17352 174 ----GLL-----------------LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGID--ESDAAFLLSIIGIS 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 281 ATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVgANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGG 360
Cdd:cd17352 231 DIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPL-ATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSN 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 755041493 361 AMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTLIV 411
Cdd:cd17352 310 AYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
50-409 |
2.21e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 58.36 E-value: 2.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 50 ISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISN 129
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 130 WFTKSERSRANTFLILGNPVTVLWMSVVsGYLIQSfgWREMFIIEGVPAIIWAFCWWVLvkdkpeqvkwladdekaalka 209
Cdd:cd17317 106 IVGPKYRSFVGILFGLFWALGYMLLALL-AYLIRD--WRWLQLAISLPGLLFLLLLWWL--------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 210 qlekeqegikavrnygeafrSRNVILLCMQYFAWSIGVYGFVLwlpsIIRSGGANL-------GMVEVgwlssvpylaat 282
Cdd:cd17317 162 --------------------PRRTIIVGLIWFVTSLVYYGLSL----NSSNLGGNLylnfflsGLVEI------------ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 283 IAMILASWASDKLqNRKLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAM 362
Cdd:cd17317 206 PAYFLALLLLDRL-GRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGV 284
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 755041493 363 ALINSMGALGSFFGSwFVGYLngSTGSPSASYIFMGVALFVSVWLTL 409
Cdd:cd17317 285 GLCSTVARVGAILAP-FIVLL--GKIGPLLPLIIFGVLALLGGLLTL 328
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
236-422 |
3.03e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.20 E-value: 3.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 236 LCMQYFAWSIGVYGFVLWLPSIIrSGGANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIG 315
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLL-AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 316 SWAvgaNHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYI 395
Cdd:pfam07690 80 LFA---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLI 156
|
170 180
....*....|....*....|....*..
gi 755041493 396 FMGVALFVSVWLTLIVKPANNQQAPAR 422
Cdd:pfam07690 157 LAILSLLAAVLLLLPRPPPESKRPKPA 183
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
43-405 |
3.46e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.99 E-value: 3.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 43 DLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPA 122
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 123 MLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGV-PAIIWAFCWwvLVKDKPEqvkwlad 201
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVlALLALLLVF--LVKDPPP------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 202 dekaalkaqlEKEQEGIKAVRNYGeAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSgganLGMVEVGWLSSVPYLAA 281
Cdd:cd17489 176 ----------VAAEEAEAGTRAFR-RLVEKKVLPPALILFLASIAYGAISTFLPLYAAE----RGISNAGLFFTVYAIAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 282 TIAMILASWASDKLqNRKLFVWPLLLIAAFAFIGSWAvgANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGA 361
Cdd:cd17489 241 LLSRPFSGKLSDRK-GPKTVIIPGLLLLALGLLLLSF--AGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAA 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 755041493 362 MALINSMGALGSFFGSWFVGYLNGSTGsPSASYIFMGVALFVSV 405
Cdd:cd17489 318 NGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLAL 360
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
79-376 |
4.73e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.57 E-value: 4.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 79 RKLIF-ICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVV 157
Cdd:cd17321 60 RKRVFlIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 158 SGYLIQSFGWREMFIIeGVPAIIWAFcwwVLVKdkpeqvkwladdekaalkaqlekeqegikavrnygeAFRSRNVILLC 237
Cdd:cd17321 140 GGLLLELFGWRWIFLI-NVPIGLVAL---LLAR------------------------------------TFSGAVLAAFL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 238 MqyfawSIGVYGFVLWLPSIIrSGGANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSW 317
Cdd:cd17321 180 L-----GAALGGLLFLLPLYL-QGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 755041493 318 AVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFG 376
Cdd:cd17321 254 LGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
73-377 |
5.73e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.59 E-value: 5.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 73 AERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVL 152
Cdd:cd17503 55 ADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 153 WMSVVSGYLIQSFGWREMFIIEGVPAIIwafCWWVLvkdkpeqvkwladdekAALKAQLekeqegikavrnygeaFRSRN 232
Cdd:cd17503 135 IGPTLGGWLTDNLSWRWIFYINLPIGIL---ALLLA----------------PLLDLRL----------------FKDRN 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 233 VILLCMQYFAWSIGVYGFVLWLPSIIrSGGANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFA 312
Cdd:cd17503 180 FTLGLLLSFLLGLGLFGAMFLLPLYL-QNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGT 258
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755041493 313 FIGSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:cd17503 259 LLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGT 323
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
51-406 |
9.53e-09 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 57.28 E-value: 9.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 51 SSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTG---VVNNIPMLAAIRFILGVVEAAVMPAMLIYI 127
Cdd:pfam00083 48 SGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGaakGKWSVYQLIVGRVLVGIGVGGASVLAPMYI 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 128 SNWFTKSERSRA----NTFLILGNPVTVlWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFC--------WWVLVKDKPEQ 195
Cdd:pfam00083 128 SEIAPKKLRGALgslyQLAITFGILLAY-IFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGllflpespRWLVEKGRLEE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 196 VK---------WLADDEKAALKAQLEKEQEGIKAvrNYGEAFRSRNV---ILLCMQYFAW--SIGVYGFVLWLPSIIRsg 261
Cdd:pfam00083 207 ARevlaklrgvPDVDRELDEIKDSLEAGQEAEKA--SWKELFSTKTRrqrLLIGVMLQIFqqLTGINAIFYYSTTIFE-- 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 262 gaNLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLL-LIAAFAFIGSWAVGANHFWISYTLLVIAGAAMY- 339
Cdd:pfam00083 283 --NLGLSDSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAgMAICFVILGIVALLGVSKSDWAGIVAIVFIALFi 360
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755041493 340 APYGP-----FFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVW 406
Cdd:pfam00083 361 AFFAMgwgpvPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIF 432
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
40-376 |
2.04e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 55.66 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAV 119
Cdd:cd17323 25 IAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIegvpAIIWAFCWWVLVkdkpeqvkwl 199
Cdd:cd17323 105 LAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWF----LAIISGFCLILI---------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 200 addekaalkaqlekeqegikavrnygeAFRSRNVILLCMqYFAWSIGVYGFVLWLPSIIRSGGANLGMVEVGwlssVPYL 279
Cdd:cd17323 171 ---------------------------FLFLPIVLLLGL-YVGLVYAILYLFLTAFPYVFGEVYGFSPGEVG----LMYL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 280 AATIAMILASWASDKLQNRKLFVW--------------PLLLIAAFA-----FIGSWAVGANHFWISYTL-LVIAGAAMY 339
Cdd:cd17323 219 PIGIGALIGSIIGGRLSDYYYRRLkkknggkpepearlPPAFIGAFLfpiglFIFGWTIYPHIHWIVPIIgSAFFGFGLM 298
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 755041493 340 APYGPFFAIIPEMLPRNVAGGAMA---LINSMGALGSFFG 376
Cdd:cd17323 299 LIFQSSLTYLVDSYPKYAASALAAntlVRSIFAAIFPLFA 338
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
279-405 |
2.69e-08 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 55.61 E-value: 2.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 279 LAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFW-ISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNV 357
Cdd:cd17369 275 VVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWlIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRV 354
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 755041493 358 AGGAMALINSMGA-LGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSV 405
Cdd:cd17369 355 RYTGASLGYQLGAiLGGGFAPLIATALVAATGSWWPVALYLAALAVISL 403
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
64-411 |
3.28e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 55.30 E-value: 3.28e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 64 FFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFI--LGVVEAAVMPAMLIYISnwftksERSRANT 141
Cdd:cd17472 47 IFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALqgSGAISSVVMALLADLTR------EENRTKA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 142 FLILGNPVTVLWM-SVVSGYLIQS-FGWREMFIIEGVPAIIwAFCWWVLVKDKPEQVKWLADDEKAALKAQLekeqegik 219
Cdd:cd17472 121 MALIGASIGIAFAiSMVLGPLLAAhLGVSGLFLITAILSLV-SLLILLFFVPDPPKIVQISEKEKKKLKKLL-------- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 220 avrnygeafRSRNVILLCMQYFAWSIGVYGFVLWLP---SIIRSGGANLGMVevgwlssvpYLAATIAMILASWASDKLQ 296
Cdd:cd17472 192 ---------KNKRLLRLDFSIFILHFVLMAFFYILPlllTQLGGGKGQLWKV---------YLPAILIGFILMVPFVIYA 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 297 NRKLFVWPLLLIA----AFAFIGSWAVGANHFWIS-YTLLVIAGAAMYAPYGPffAIIPEMLPRNVAGGAMALINSMGAL 371
Cdd:cd17472 254 EKKGKMKQVFVSSilliAVGFLLLLFAATSLWLLIiGLIIFFIGFNLLEALLP--SLVSKIAPKEYRGTAMGIYNTSQFL 331
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 755041493 372 GSFFGSWFVGYLNgstGSPSASYIFMGVALFVSVWLTLIV 411
Cdd:cd17472 332 GSFLGGALGGLLW---GLLGYSSVFLTILILALLWLLVSF 368
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
14-381 |
4.88e-08 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 54.72 E-value: 4.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 14 IMPIIFITYSLAYLDRANFSFASAAgINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACA 93
Cdd:cd17488 4 ILASMFIGYAVFYLTRKSFNAAMPA-MLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIIN 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 94 SLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFII 173
Cdd:cd17488 83 ILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 174 EGVPAIIWAFCWWVLVKDKPEQVKWLADDEKAALKAQLekeqegikAVRNYGEAFRSrnvillcmQYFAWSigvygfvlw 253
Cdd:cd17488 163 PGIIAILMGIVLCWRLRDRPPYIWLLAFCYVLVYVVRT--------AINDWGNLYLS--------ETHGYS--------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 254 lpsiIRSGGANLGMVEVGWLssvpylaatIAMILASWASDKL--QNRklfvWPLLLIAA----FAFIGSWAVGANHFWIS 327
Cdd:cd17488 218 ----LVKANSAVSLFEVGGL---------IGALVAGWGSDKLfkGNR----GPMNLIFAlgllVSVGALWLVPVHSYWLL 280
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 755041493 328 YTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVG 381
Cdd:cd17488 281 ATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLA 334
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
41-189 |
6.59e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.12 E-value: 6.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 41 NEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVM 120
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755041493 121 PAMLIYISNWFTKSERSRA----NTFLILGNPVTvlwmSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLV 189
Cdd:cd17325 307 PATLALLADIVPPEGRGTAmglfNTAFSLGMVLG----PLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
47-188 |
8.61e-08 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 53.88 E-value: 8.61e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 47 TKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLI--------FICLILWGACASLTGVVnnipmlAAIRFILGVVEAA 118
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFglaifvtsTLNMLIPIAARVHYGCV------IFVRILQGLVEGV 120
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 119 VMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVL 188
Cdd:cd17382 121 TYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV 190
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
58-409 |
1.44e-07 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 53.48 E-value: 1.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 58 FFLGYFFFqipGALyAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERS 137
Cdd:TIGR00898 140 VLLGSFVF---GYL-SDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRA 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 138 RANTFLILGNPVTVLWMSVVsGYLIQSfgWREMFIIEGVPAIIWAFCWWVLvkdkPEQVKWLADD---EKA--------- 205
Cdd:TIGR00898 216 IVGTLIQVFFSLGLVLLPLV-AYFIPD--WRWLQLAVSLPTFLFFLLSWFV----PESPRWLISQgriEEAlkilqriak 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 206 ---------ALKAQLEKEQEGIKAVRNYGEAFRSRNV----ILLCMQYFAWSIGVYGFVLWLPSIirsgGANL------- 265
Cdd:TIGR00898 289 ingkklpaeVLSLSLEKDLSSSKKQYSFLDLFRTPNLrkttLCLMMLWFTTAFSYYGLVLDLGNL----GGNIyldlfis 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 266 GMVEVgwlssvpylaatIAMILASWASDKLQNRKLFVwPLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYGPF 345
Cdd:TIGR00898 365 GLVEL------------PAKLITLLLIDRLGRRYTMA-ASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMV 431
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755041493 346 FAIIPEMLPRNVAGGAMALINSMGALGSFFgSWFVGYLNGStgSPSASYIFMGVALFVSVWLTL 409
Cdd:TIGR00898 432 YLYTAELYPTVVRNLGVGVCSTMARVGSII-SPFLVYLGEK--WLFLPLVLFGGLALLAGILTL 492
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
12-374 |
4.48e-07 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 51.57 E-value: 4.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 12 LYIMPIIFITYSLAYLDRANFSFASAAGINEdLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGA 91
Cdd:cd17343 2 LTIFASMFVGYTLYYFNRKSFSFVLPSLMNE-LGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 92 CASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMF 171
Cdd:cd17343 81 TTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 172 IIEGVPAIIWAFCWWVLVKDKPEQVKwLADDEKAALKAQLEKEQEGIKAVRnygEAFRSRNVILLCMQYFAWSIGVYGFV 251
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVG-LNNIEEEESKGKKKKSPRGESTLK---ELLLSPFLWLLSLGYLVVFGVKTAVT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 252 LW--------LPSIIRSGGANLGMVEVGWLssvpyLAATIAMILASWASDKLQNRK-------LFVWPLLLIAA--FAFI 314
Cdd:cd17343 237 DWgqlfliqdKGQSALTGSSFMSSLEVGGF-----VGSIAAGYLSDWAVAKHGSSSrgnprmpLALVFMAGLTVslHLFR 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 315 GSWAVGANHFWIsYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSF 374
Cdd:cd17343 312 VHITSDSSELFI-LLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGV 370
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
43-411 |
7.43e-07 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 51.04 E-value: 7.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 43 DLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPA 122
Cdd:cd17358 35 SLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 123 MLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLiqsfGWREMFIIEGVPAIIWAFCWWVLvkdkPEQVKWLA-- 200
Cdd:cd17358 115 VPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFL----PWRTLALIGAIPPVVFLILLFFI----PESPRWLAkk 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 201 --------------------DDEKAALKAQLEKEQEGIKAVRnYGEAFRSRN----VILLCMQYFAWSIGVYGFVLWLPS 256
Cdd:cd17358 187 greeeaekslqflrgkdadiSKEAAEIQEELAELEKEAKESS-FSDLFQRKYlkplVIGLGLMLFQQLSGINAVIFYASS 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 257 IIRSGG----ANLGMVEVGwlssvpyLAATIAMILASWASDKLQNRklfvwPLLLI-AAFAFIGSWAVGAnHFWI----- 326
Cdd:cd17358 266 IFDEAGsgldPNTATIIIG-------VVQVVGTLVATLLVDRLGRR-----PLLLVsAIGMGIGLLALGL-YFYLqehga 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 327 ---SYTLLVIAGAAMY-----APYGP-FFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFM 397
Cdd:cd17358 333 llsSVSWLPLVGLVIYiisfsIGLGPlPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAWGASGTFWIFA 412
|
410
....*....|....
gi 755041493 398 GVALFVSVWLTLIV 411
Cdd:cd17358 413 GICGLALVFVLLFV 426
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
53-189 |
9.03e-07 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 50.93 E-value: 9.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 53 LLGAlFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPM--LAAIRFILGVVEAAVMPAMLIYISNW 130
Cdd:cd17381 70 ILGS-FFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAgyLIAVRALEGLGEGVTFPAMHAMWASW 148
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 755041493 131 FTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLV 189
Cdd:cd17381 149 APPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV 207
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
42-407 |
1.12e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 50.25 E-value: 1.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 42 EDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 122 AMLIYISNWFTKSERSRantflILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVkdkpeqvkwlad 201
Cdd:cd17477 104 VSESWLNALATNENRGR-----VLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLL------------ 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 202 dekAALKAQLEKEQEGIKAVRNYGeafrsRNVILLCMQYFAWSIGVYGFVLWLPsiIRSGGANLGMVEVGWLSSVPYLAA 281
Cdd:cd17477 167 ---LTRRAAPEIEEAESISLRRLL-----RIAPLALLGAFVAGFLEGAFYSLLP--LYGLRLGLSVAQAALLLAAFVLGG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 282 TIAMILASWASDKLQNRKLFVWpLLLIAAFAFIGsWAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGA 361
Cdd:cd17477 237 LLLQWPLGWLADRFDRRRVLLG-CALLGALAALL-LPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 755041493 362 MALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWL 407
Cdd:cd17477 315 NAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
233-429 |
1.13e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 50.26 E-value: 1.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 233 VILLCMQYFAWSIGVYgfvlwLPSIIRSGGanLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFA 312
Cdd:COG2807 25 LVALNLRPAITSVGPL-----LPEIRADLG--LSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 313 FIGSWAVGANHFWISYTLLVIAGAAMYAPygpFFAIIPEMLPRNVaGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSA 392
Cdd:COG2807 98 LLRSLAPSVALLLAGTALIGAGIAVGNVL---LPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGA 173
|
170 180 190
....*....|....*....|....*....|....*..
gi 755041493 393 SYIFMGVALFVSVWLTLIVKPANNQQAPARMMRAGRP 429
Cdd:COG2807 174 LAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRS 210
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
50-406 |
1.69e-06 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 50.69 E-value: 1.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 50 ISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFIC-----LILWGACASLtgVVNNIPMLAAIRFILGVVEAAVMPAML 124
Cdd:PRK08633 48 LTAIVNALFLLPFLLLSSPAGFLADKFSKNRVIRIVklfevGLTLLIVLAY--YLGWFWLAFAVTFLLGAQSAIYSPAKY 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 125 IYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFG-----------WREMFIIEGVPAIIWAFCWwvLVKDKP 193
Cdd:PRK08633 126 GIIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNgntpseilgriAPAGLVLLAVAVLGLIFAY--RLPKVP 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 194 EQVKWLADDEKAALKAQLekeQEGIKAVrnygeafRSRNVILLC---MQYFaWSIGvygfVLWLPSIIRSGGANLGMVEV 270
Cdd:PRK08633 204 AAAPEVFDKKKYLFPKLL---WRNLKLL-------RSDRVLWLAiigLSYF-WFIS----QLAQANFPAYAKEVLGLDNT 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 271 gWLSSVPYLAATIAMILASWASDKLQNRK--LFVWPL--LLIAAFAFIGSWavgANHFWISYTLLVIAG--AAMYAPygP 344
Cdd:PRK08633 269 -FQVQYLLAASAIGIGIGSLLAGRLSGRHieLGLVPLgaLGLALSLFLLPT---APSLASVLVLFFLFGfsAGLFIV--P 342
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755041493 345 FFAIIPEMLPRNVAGGAMA---LINSMGALGSFFGSWFVGYLNGSTgsPSASYIFMGVALFVSVW 406
Cdd:PRK08633 343 LNALIQFRAPEKELGKVLAannFLQNVGMLLFLALTTLFSGLGLSP--AGLFYLIALVTLIGTLY 405
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
229-429 |
4.51e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 48.27 E-value: 4.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 229 RSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANLGMVevGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLI 308
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQL--GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 309 AAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYgpfFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTG 388
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGA---LALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 755041493 389 SPSASYIFMGVALFVSVWLTLIVKPANNQQAPARMMRAGRP 429
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALL 207
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
42-194 |
8.46e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.56 E-value: 8.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 42 EDLGITKGISSLLGALFFLGYFFFQIPGALYAER--RSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAV 119
Cdd:COG2271 209 EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGA 288
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755041493 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKPE 194
Cdd:COG2271 289 FGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
242-407 |
1.06e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 242 AWSIGVYGFVLwlPSIIRSGGANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGa 321
Cdd:cd17316 12 AYDFFLIGFVA--PVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPT- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 322 nhFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSA---SYIFMG 398
Cdd:cd17316 89 --PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGwriLFLIGA 166
|
....*....
gi 755041493 399 VALFVSVWL 407
Cdd:cd17316 167 LPALLALLL 175
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
52-342 |
1.58e-05 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 46.93 E-value: 1.58e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 52 SLLGAL---FFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGV-----VNNIPMLAAIRFILGVVEAAVMPAM 123
Cdd:cd17344 62 ELLGALdsaFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLgyywnIHSLWYFVVVQILAGLFQSTGWPSV 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 124 LIYISNWFTKSERSrantfLILGnpvtvLWMSVVS-----GYLIQ----SFGWREMFIiegVPAIIWAF----CWWVLVK 190
Cdd:cd17344 142 VACVGNWFGKGKRG-----LIMG-----IWNSHTSvgnilGSLIAgifvSSAWGLSFI---VPGIIIAAmgvlVFLFLVE 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 191 DKPEQVKWLaddekaalkaqlekeqegikavrnygeafrsrnvilLCMqYFAWSIGvYGFVLWLPSIIrSGGANLGMVEV 270
Cdd:cd17344 209 HPPGVIEFS------------------------------------LCL-FFAKLVS-YTFLYWLPLYI-SNTAILSAKKA 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755041493 271 GWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPY 342
Cdd:cd17344 250 GDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMTTNIVLLIVCGLLVNGPY 321
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
164-411 |
2.06e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 46.42 E-value: 2.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 164 SFGWREMFIIEGVPAIIWAFCWWVLVKDKPEQVKwladdekaalkaqLEKEQEGIKAVRNYgeafrsrnvillcmqyFAW 243
Cdd:cd17339 149 GGGWRGALAIWALPALLALLIWLPQLRRRKRAAA-------------AAAPLTKISVWRSP----------------LAW 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 244 SIGV---------YGFVLWLPSIIRSGGanLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFI 314
Cdd:cd17339 200 QVTLfmglqsllfYTLMAWLPTILIDAG--LSAATAGWLLSLFQLVGIPASLLVPILATRLKNQRPIVVLLAVLFIIGVL 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 315 GSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMAliNSMGALGSFFGSWFVGYLNGSTGSPSASY 394
Cdd:cd17339 278 GLLFAPTALALLWAVLLGLGGGAAFSLALTLISLRSSDPAEAAALSGMA--QSVGYLLAALGPLLFGVLHDLTGSWTAPL 355
|
250
....*....|....*..
gi 755041493 395 IFMGVALFVSVWLTLIV 411
Cdd:cd17339 356 VLLLALTVLQLVAGLGA 372
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
79-383 |
2.14e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.42 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 79 RKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVvEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVS 158
Cdd:cd17504 61 KKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI-GGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 159 GYLIQSFGWREMFIIEGVPAIIWAFCwwvlvkdkpeqvkwladdekaalkaqlekeqegIKAVRNygEAFRSRNVILLCM 238
Cdd:cd17504 140 GWIVQHLGWRWIFWTAAPVAVLLAAL---------------------------------VPLIDL--RLLRRRNVLLANI 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 239 QYFAWSIGVYGFVLWLPSII---RSGGANLGMVEVGWLssvpYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIG 315
Cdd:cd17504 185 TALLAGFGMFMVFQLLPQLLqlpTPTGFGLGITEAGLL----LLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVG 260
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 316 SWAVGANHF--WISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYL 383
Cdd:cd17504 261 LLLLALLHSslWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
42-188 |
2.71e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.07 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 42 EDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd06173 237 EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNV 316
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755041493 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVL 188
Cdd:cd06173 317 PLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
234-377 |
5.51e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 45.31 E-value: 5.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 234 ILLCMQYFAWSIGVYGFVLWLPSIIRSGGanlGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAF 313
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG---PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSI 77
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755041493 314 IGSWAVGANHFWISYTLLVIAGAAMyapyGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:cd06179 78 VAGTAKSVNMLIGGQALIGIGAGTQ----GLGAAVASELVPNKYRGLVQGVVNLVASPGSALGP 137
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
52-401 |
5.65e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.00 E-value: 5.65e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 52 SLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWF 131
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 132 TKSERSR---ANTFLILGNPVTVLWMSVVsgyLIQSFGWREMFIIEGVPAIIWAFCWWVLvkdkpeqvKWLADDEKAALK 208
Cdd:cd17333 114 EESSATRlnvLHGFFGLGALIGPLIATSL---LTSELSWSWAYLIIGLIYLLLAILILLT--------LFPELPSARNPQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 209 AQLEKEQEGIKavrnygEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSI-IRSGGANLGMveVGWLSSVPYLAATIAMIL 287
Cdd:cd17333 183 QSVGAFSASAS------RLLRNPSIILGALALFLYVGAETAFSSWVPSYlVEKKHVSDGL--AGYLLSGFWVGITIGRLL 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 288 ASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLviaGAAMYAPYGPFFAIIPEMLPRNvAGGAMALINS 367
Cdd:cd17333 255 GGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALL---GLFMAALFPTILSLGISNLPYA-KGKGTSVLLA 330
|
330 340 350
....*....|....*....|....*....|....
gi 755041493 368 MGALGSFFGSWFVGYLNGSTGSPSASYIFMGVAL 401
Cdd:cd17333 331 AGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYA 364
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
68-391 |
7.18e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.95 E-value: 7.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 68 PGALYAER---RSVRKLIFICLI-LWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFL 143
Cdd:PRK11551 65 PGALLGGRladRIGRKRILIVSVaLFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLM 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 144 ILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAfcwwvlvkdkPEQVKWLADDEKAALKAQLEKEQEGIKAVRn 223
Cdd:PRK11551 145 YCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLV----------PLLMRWLPESRAFAQAAGAGKQRAPVLRAL- 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 224 YGEAfRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGanLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKL--- 300
Cdd:PRK11551 214 FGEG-RATATLLLWISYFFTLIVLYFLLNWLPSLLVGQG--LSRSQAGLVQIAFNIGGALGSLLIGALMDRLRPRRVvll 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 301 -FVWPLLLIAAFAFIGSWAVganhfwisyTLLVIAGAAMYAPYGP--FFAIIPEMLPRNVAGGAMALINSMGALGSFFGS 377
Cdd:PRK11551 291 iYAGILASLAALAAAPSFAG---------MLLAGFAAGLFVVGGQsvLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGP 361
|
330
....*....|....
gi 755041493 378 WFVGYLNGSTGSPS 391
Cdd:PRK11551 362 LLAGQLLALGRSTV 375
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
257-405 |
7.61e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 44.46 E-value: 7.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 257 IIRSGGANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIgswAVGANHFWISYTLLVIAGA 336
Cdd:cd17370 223 ILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLG---FALGSSLWLLLLGFILWGL 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755041493 337 AMYAPYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLnGSTGSPSASYIFMGVALFVSV 405
Cdd:cd17370 300 YMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL-WDLISPSAAFLFSAVLALIAL 367
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
79-406 |
1.09e-04 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 44.10 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 79 RKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRA---NTFLIlgnpVTVLWMS 155
Cdd:cd17359 66 RKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLvslNQLMI----VFGQLLA 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 156 VVSGYLIQSF---------GWREMFIIEGVPAIIWAFCWWVLvkdkPEQVKWLADDEKAALkaqlekeqegikavrnyge 226
Cdd:cd17359 142 YIVNYLIANAggadwlgaeGWRWMLGLEAIPAILFLLGMLFI----PESPRWLVSKGKPIL------------------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 227 afrsrnVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANLGMVEVGwlSSVPYLAATIAMILASWASDKLQNRKLFVWPLL 306
Cdd:cd17359 199 ------IIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQ--TIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSI 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 307 LIAAFAFIGSWA-----VGANHFWISYTLLVIAGAAMYAPYGPF-FAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFV 380
Cdd:cd17359 271 GMAISLLLIGTAfyfapGSQASGIVALVLILLFVAFFAMSWGPVtWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTF 350
|
330 340
....*....|....*....|....*...
gi 755041493 381 GYLNGSTGSPSASYIF--MGVALFVSVW 406
Cdd:cd17359 351 PILLAAFGLAFTFLIFavICVLAFLFVW 378
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
270-422 |
1.25e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 270 VGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANH--FWISYTLLVIAGAAMyAPYGP-FF 346
Cdd:cd06173 36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlsLWLLLVLAFLLGIAS-AFFGPaRQ 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755041493 347 AIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGsTGSPSASYIFMGVALFVSVWLTLIVKPANNQQAPAR 422
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVA-LLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGES 189
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
42-190 |
1.41e-04 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 43.73 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 42 EDLGITK---GISSLLGALFFLGYFFFqipGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAA 118
Cdd:cd17335 226 QDLGGSKtliGLLWTVGVVSEIPFFFF---SSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFAL 302
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755041493 119 VMPAMLIYISNWFTKSERSRANTFL-ILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVK 190
Cdd:cd17335 303 VWAAAVSYASAAAPPGLRATAQGLLqGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLIQR 375
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
40-403 |
1.62e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.76 E-value: 1.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAV 119
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 120 MPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQsFGWREMFIIEGVPAIIWAFCWWVLVKDKPEQvkwl 199
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAAAVLFLLAALVLLFLLPETRPK---- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 200 addekaalkaqlEKEQEGIKAVRNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANlGMVEVGWLSSVPYL 279
Cdd:cd17329 181 ------------RRAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL-GESLLGLLLALNAL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 280 AATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLVIaGAAMYAPYGPffAIIPEMLPRNVAG 359
Cdd:cd17329 248 LIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTL-GEMLVFPAVQ--TLVAALAPPDKRG 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 755041493 360 GAMALINSMGALGSFFGSWFVGYLngsTGSPSASYIFMGVALFV 403
Cdd:cd17329 325 SYMGFYALAWGLGRAIGPLVGGLL---LDLLGPGLPWLILAALG 365
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
254-410 |
2.96e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.95 E-value: 2.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 254 LPSIIRSGGANLgmVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFvwpllLIAAFAF-IGSWAVG-ANHFWISYTLL 331
Cdd:cd17503 19 LPTIMGDLGASL--DTVQWVITSYLLALAIMIPLSGWLADRFGTRRLF-----LTALALFtLGSLLCGlAPNLASLIIFR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 332 VI--AGAAMYAPYGpfFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTL 409
Cdd:cd17503 92 ILqgFGGGVLIPLA--QTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL 169
|
.
gi 755041493 410 I 410
Cdd:cd17503 170 L 170
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
280-413 |
3.39e-04 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 42.75 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 280 AATIAMILASWASDKLQNRKLFVWPLLLIAAFAF-IGSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVA 358
Cdd:cd17368 270 ANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYpVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVR 349
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 755041493 359 GGAMALINSMG-ALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTLIVKP 413
Cdd:cd17368 350 STGFSLVYALAvAIFGGFAQFIVTWLIELTGSPLAPAWYLMGAALLGLLATLMLRE 405
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
42-259 |
3.53e-04 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 42.60 E-value: 3.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 42 EDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMP 121
Cdd:cd17438 27 KDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGGSLP 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 122 AMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGW-------------REMFIIEGVPAIIWAfcwwVL 188
Cdd:cd17438 107 IVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWgfsmgtnyhfhswRVFVIICALPCIASI----IA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 189 VKDKPEQVKWLAD----DEKAALKAQL-------EKEQEGIKAVRNygeaFRSRNVILLCMQYFAWSIGVYGFVLWLPSI 257
Cdd:cd17438 183 LKFMPESPRFLLEmgkhDEAWMILKNIhdtnmraKGTPEKVFTVSN----IKRKNTLFLAVVWFTMAFSYYGLTVWFPDM 258
|
..
gi 755041493 258 IR 259
Cdd:cd17438 259 IR 260
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
40-186 |
3.56e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.59 E-value: 3.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVV--NNIPMLAAIRFILGVVEA 117
Cdd:cd17316 204 LQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLlsGSPTLLLLLLFILSFFVG 283
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 118 AVMPAMLIYISNWFTKSERSRANTFLI-LGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWW 186
Cdd:cd17316 284 GVWGALYAYLAELFPTEVRATGVGLSYnLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
79-402 |
3.99e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.18 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 79 RKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVS 158
Cdd:cd17315 64 RKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 159 GYLIQSF--GWREMFIIEGVPAIIWAFCWWVLVKDKPEQVkwladdekaalkaqlekeqegikavrnygeafrsrNVILL 236
Cdd:cd17315 144 LALSLSPpgWWRLMFALAAVPALLQLLLMFFLPESRALLV-----------------------------------GVGLQ 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 237 CMQYFAwsiGVYGFVLWLPSIIRSGGANLGMVEVGWLSSVPYLAATiamILASWASDKLQNRKLFVWPLLLIAAFAFIGS 316
Cdd:cd17315 189 LLQQLT---GINAVMYYAPTIFKSAGGGTASILASIIVGVVNLLAT---LVAIRLVDKVGRRPLLLIGFAGMAASLLLLA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 317 WAVGANHFWISYTLLVIAGAAMYA-----PYGPFFAII-PEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSP 390
Cdd:cd17315 263 IAFLLPALAKAAGWLALLGILLYIaafamGAGPVPWLLlSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTIGLA 342
|
330
....*....|..
gi 755041493 391 SASYIFMGVALF 402
Cdd:cd17315 343 GVFIFFAAVCLL 354
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
52-407 |
7.64e-04 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 41.48 E-value: 7.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 52 SLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIP---MLAAIRFILGVVEAAVMPAMLIYIS 128
Cdd:cd17357 52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKspeLLIFGRFLVGIACGLSTGFVPMYLQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 129 NWFTKSERSRANTFLILGNPVTVLWMSVVSgyLIQSFG----WREMFIIEGVPAIIWAFCWWVLvkdkPEQVKWL---AD 201
Cdd:cd17357 132 EISPSELRGALGSLTQIGVTLGILLGQVFG--LPSVLGtetlWPYLLFFPGIPALLQLAALPFF----PESPKFLlisKG 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 202 DEKAALKA----------------QLEKEQEGIKAVRNYG--EAFRSRN--------VILLCMQYFA--WSIGVYGFvlw 253
Cdd:cd17357 206 DEEEAEKSlkflrgieddvdqeleEIKKESEQMGDQKQVSlmQLLRDPSlrlplllvLVVSASQQFSgiNAIFFYST--- 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 254 lpSIIRSggANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIgsWAVGANHF----WISYT 329
Cdd:cd17357 283 --FIFEN--AGFSPQLAEWANLGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAVALLL--MSVFLFLSeqnsWMSYG 356
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 330 LLV-----IAGAAMYAPYGPFFaIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNgSTGSPSASYIFMGVALFVS 404
Cdd:cd17357 357 CIVaiflfIFFFAIGLGPIPWF-IGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQ-SIGGGFVFIIFAIPCALFL 434
|
...
gi 755041493 405 VWL 407
Cdd:cd17357 435 LYL 437
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
236-419 |
9.21e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 41.15 E-value: 9.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 236 LCMQYFAWSIGVYGFVLWLPSIIRSggANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIaAFAFIG 315
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEA--FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLI-SLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 316 SWAvgANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNvAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYI 395
Cdd:cd17333 78 IFA--TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYL 154
|
170 180
....*....|....*....|....
gi 755041493 396 FMGVALFVSVWLTLIVKPANNQQA 419
Cdd:cd17333 155 IIGLIYLLLAILILLTLFPELPSA 178
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
238-422 |
1.11e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.10 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 238 MQYFAWSIGVYGFVLWLPsIIRSGGANLGmvEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSW 317
Cdd:cd17355 11 ILILSWGIRYYFGVFIIP-IIAEFGWSRA--VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 318 AVGANHFWISYTLLVIAGAAMYapYGPFFAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFM 397
Cdd:cd17355 88 ATSLWQLYLLWGLLGGGGAGTL--AAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLA 165
|
170 180
....*....|....*....|....*..
gi 755041493 398 GVALFVS--VWLTLIVKPANNQQAPAR 422
Cdd:cd17355 166 LLALLVLvpVLLLLRRRPADLALRAYD 192
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
253-422 |
1.92e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.23 E-value: 1.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 253 WLPSIIRSGGANLGMVevGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAvgaNHFWISYTLLV 332
Cdd:cd17478 18 LLPLLIAKLGLSYAQA--GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA---PNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 333 IAGA--AMYAPYGpffAIIPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPsASYIFMGVALFVSVWLTLI 410
Cdd:cd17478 93 LAGIgsAAFHPEG---ARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGL-GLLILLIIPGLAVALLLLR 168
|
170
....*....|..
gi 755041493 411 VKPANNQQAPAR 422
Cdd:cd17478 169 LRPLKKPEAKKA 180
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
40-190 |
1.99e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 40.28 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 40 INEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAv 119
Cdd:PRK11102 17 IAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAA- 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755041493 120 mPAMLI--YISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVK 190
Cdd:PRK11102 96 -ASVVInaLMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
17-183 |
2.10e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.10 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 17 IIFITYSLAYLDRANFSFASAAGINEDLGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRK-LIFICLILWGACASL 95
Cdd:cd06174 207 LLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKpLLLIGLLLMALGLAL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 96 TGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVVSGYLI-QSFGWREMFIIE 174
Cdd:cd06174 287 LLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVL 366
|
....*....
gi 755041493 175 GVPAIIWAF 183
Cdd:cd06174 367 AVLLLLAAI 375
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
51-411 |
2.21e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 40.03 E-value: 2.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 51 SSLLGALFFlgyfffQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNW 130
Cdd:cd17362 47 GSLLGALLG------SLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAET 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 131 FTKSER----SRANTFLILGnpvtvlwmsVVSGYLIQSF------GWREMFIIEGVPAIIWAFCWWVLvkdkPEQVKWLA 200
Cdd:cd17362 121 SPSHIRgllvSLKELFIVLG---------ILLGYVSGYAfadvvgGWRYMYGLAAPPALLLGIGMWFL----PPSPRWQG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 201 ddekaalkaqlekeqegikavrnygeAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGG----ANLGMVEVGwLSSV 276
Cdd:cd17362 188 --------------------------NYRKPLIIGLGLVLFQQITGQPSVLYYAATIFKSAGfsaaSDATLVSVG-LGVF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 277 PYLAATIAMILAswasDKLQNRKLF-------VWPLLLIAAFAFIGSwAVGANHFWISYTLLVIAGAAMYAPYGPF-FAI 348
Cdd:cd17362 241 KLLMTIVAVLLV----DKLGRRPLLlggvsgmVVSLFLLAAYNLFVQ-MGPAGLAWLSLVALLLYVGAYQISFGPIsWLM 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755041493 349 IPEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTLIV 411
Cdd:cd17362 316 VSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLPLQELIGLPGTFLGFGVIGVLALLFIYFTV 378
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
44-411 |
2.40e-03 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 40.09 E-value: 2.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 44 LGITKGISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNI-PMLAAIRFILGVVEAAVMPA 122
Cdd:cd17314 33 FGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLAGYTYLSYVFNSfPLSYACFVFIGAGTGILYGS 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 123 MLIYISNWFTkSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWAFCWWVLVKDKPEqvkwladD 202
Cdd:cd17314 113 AVLVTTQYFP-DTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGFKEPP-------D 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 203 EKAALKAQLEKEQegikavrNYGEAFRSRNVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANLGMVEVGWLSsVPYLAAT 282
Cdd:cd17314 185 NQARLHVQKKKTQ-------TMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTKLMS-IYGLFNA 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 283 IAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAIIPEMLPRNVAGGAM 362
Cdd:cd17314 257 FGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLY 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 755041493 363 ALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTLIV 411
Cdd:cd17314 337 GILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
79-206 |
2.48e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 40.07 E-value: 2.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 79 RKLIFICLILWGACASLT-GVVNNIPMLAAIRFILGVVEAAVMPAMLIYISNWFTKSERSRANTFLILGNPVTVLWMSVV 157
Cdd:PRK03893 84 RRLAMVISIVLFSVGTLAcGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQV 163
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 755041493 158 SGYLIQSFGWREMFIIEGVPAIiwaFCWWvLVKDKPEQVKWLADDEKAA 206
Cdd:PRK03893 164 YSLVVPVWGWRALFFIGILPII---FALW-LRKNLPEAEDWKEKHAGKA 208
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
269-412 |
4.77e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 39.09 E-value: 4.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 269 EVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPYGPFFAi 348
Cdd:cd17319 39 QYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALA- 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755041493 349 ipEMLPRNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPSASYIFMGVALFVSVWLTLIVK 412
Cdd:cd17319 118 --EWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLR 179
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
50-410 |
4.83e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 4.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 50 ISSLLGALFFLGYFFFQIPGALYAERRSVRKLIFICLILWGACASLTGVVNNIPMLAAIRFILGVVEAAVMPAmLIYISN 129
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVA-QAYIAD 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 130 WFTKSERSRANTFLILGNPVTVLWMSVVSGYLIQSFGWREMFIIEGVPAIIWA-FCWWVLVKdkpeqVKWLaddekaalk 208
Cdd:cd17330 114 ITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLvLVLFFLPP-----LRRL--------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 209 aqlekeqegikavrnygeafrsrnVILLCMQYFAWSIGVYGFVLWLPSIIRSGGANLGMVevgwLSSVPYLAATIAMILA 288
Cdd:cd17330 180 ------------------------LLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLL----LALVGIAGILAQLLLI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 289 SWASDKLQNRKLFVWPLLLIAAFAFIGSWAVGANHFWISYTLLVIAGAAMYAPygpFFAIIPEMLPRNVAGGAMALINSM 368
Cdd:cd17330 232 PRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPA---LSALLSKSVPSKEQGKAQGIIQSL 308
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 755041493 369 GALGSFFGSWFVGYLNGSTGsPSASYIFMGVALFVSVWLTLI 410
Cdd:cd17330 309 QSLARIIGPLLAGPLYSFLG-PGVPFLLAAGLLLIALFLLSL 349
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
241-410 |
7.65e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 38.34 E-value: 7.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 241 FAWSIGVYGFVLWLPsIIRSGGANLGMVEVGWLSSVPYLAATIAMILASWASDKLQNRKLFVWPLLLIAA----FAFIGS 316
Cdd:COG2211 20 LGLNLAFGLLSAYLL-YFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWILIGAiplaLSFVLL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755041493 317 WAVGANHFWISYTLLVIAGAAMYAPYG----PFFAIIPEMLP-RNVAGGAMALINSMGALGSFFGSWFVGYLNGSTGSPS 391
Cdd:COG2211 99 FTAPDLSPTGKLIYALVTYLLLGLAYTlvniPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA 178
|
170 180
....*....|....*....|....
gi 755041493 392 AS-----YIFMGVALFVSVWLTLI 410
Cdd:COG2211 179 ALgyrltALIFAVLGLLAFLLTFF 202
|
|
| |
