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Conserved domains on  [gi|754869839|ref|WP_042230458|]
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MULTISPECIES: AraC family transcriptional regulator [Lactococcus]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 12084213)

AraC family transcriptional regulator with an AraC family helix-turn-helix (HTH) domain and a cupin-like domain as its effector/ligand-binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-268 1.24e-24

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 94.93  E-value: 1.24e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839   185 KISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKIRSEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 754869839   265 KEFR 268
Cdd:smart00342  81 SEYR 84
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
28-82 5.11e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


:

Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 44.45  E-value: 5.11e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 754869839  28 PHLHFDIELAFVLEGAGQVITQEQCFEIKAGQAIIFNSCQVHEL--SSSDSMKLLIL 82
Cdd:COG1917   38 WHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFrnLGDEPAVLLVV 94
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-268 1.24e-24

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 94.93  E-value: 1.24e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839   185 KISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKIRSEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 754869839   265 KEFR 268
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
142-270 1.27e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 89.07  E-value: 1.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 142 LLLDRLLSISEYSILSSSEQNKLMDLQERMERISSYIHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKI 221
Cdd:COG2207  125 LLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLREL 204

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 754869839 222 RSEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLPKEFRKN 270
Cdd:COG2207  205 RLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKR 253
HTH_18 pfam12833
Helix-turn-helix domain;
191-270 6.83e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 79.56  E-value: 6.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839  191 IASHEGLSRTYFSHFFKSNFGINFNEYLNKIRSEKARTLL-SSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLPKEFRK 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 754869839  270 N 270
Cdd:pfam12833  81 R 81
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
141-270 5.74e-12

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 65.08  E-value: 5.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 141 SLLLDRLLSISEYSILSSSEQNklmdlQERMERISSYIHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNK 220
Cdd:PRK13503 148 ILFMQLLVLLRKSSLQENGENS-----DARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNR 222

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 754869839 221 IRSEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLPKEFRKN 270
Cdd:PRK13503 223 LRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIRQG 272
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
28-82 5.11e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 44.45  E-value: 5.11e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 754869839  28 PHLHFDIELAFVLEGAGQVITQEQCFEIKAGQAIIFNSCQVHEL--SSSDSMKLLIL 82
Cdd:COG1917   38 WHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFrnLGDEPAVLLVV 94
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 27-80 4.41e-04

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 38.01  E-value: 4.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 754869839   27 KPHLH-FDIELAFVLEGAGQVITQEQCFEIKAGQAIIFNSCQVHELS--SSDSMKLL 80
Cdd:pfam07883  12 PPHRHpGEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRFRntGDEPARLL 68
cupin_MAE_RS03005 cd06987
Microcystis aeruginosa MAE_RS03005 and related proteins, cupin domain; This family includes ...
 28-84 7.54e-03

Microcystis aeruginosa MAE_RS03005 and related proteins, cupin domain; This family includes bacterial and some eukaryotic proteins homologous to MAE_RS03005, a Microcystis aeruginosa protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380392 [Multi-domain]  Cd Length: 122  Bit Score: 35.70  E-value: 7.54e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 754869839  28 PHLH-FDIELAFVLEGAGQVITQEQCFEIKAGQAIIFNSCQVHELSSSDSMKLLILQF 84
Cdd:cd06987   43 PNTHpAAHEMFFVLAGEGRAYCDGQRVPLRPGDALVVPPGSEHVIENTGSGRLYCLTL 100
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
185-268 1.24e-24

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 94.93  E-value: 1.24e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839   185 KISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKIRSEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLP 264
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 754869839   265 KEFR 268
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
142-270 1.27e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 89.07  E-value: 1.27e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 142 LLLDRLLSISEYSILSSSEQNKLMDLQERMERISSYIHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKI 221
Cdd:COG2207  125 LLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLREL 204

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 754869839 222 RSEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLPKEFRKN 270
Cdd:COG2207  205 RLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKR 253
HTH_18 pfam12833
Helix-turn-helix domain;
191-270 6.83e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 79.56  E-value: 6.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839  191 IASHEGLSRTYFSHFFKSNFGINFNEYLNKIRSEKARTLL-SSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLPKEFRK 269
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 754869839  270 N 270
Cdd:pfam12833  81 R 81
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 169-269 1.95e-18

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 84.72  E-value: 1.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 169 ERMERISSYIHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKIRSEKARTLLSSSkDNLLNIAYMCGFSD 248
Cdd:COG2169   84 DLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTG-LSVTDAAYAAGFGS 162

                         90       100
                 ....*....|....*....|.
gi 754869839 249 IRTLNTAFLKSYGVLPKEFRK 269
Cdd:COG2169  163 LSRFYEAFKKLLGMTPSAYRR 183
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 169-269 2.32e-17

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 80.97  E-value: 2.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 169 ERMERISSYIHENYDHKISLEMIASHEGLS-RTyFSHFFKSNFGINFNEYLNKIRSEKARTLLSSSKDNLLNIAYMCGFS 247
Cdd:COG4977  210 PRLARAQAWMEANLEEPLSVDELARRAGMSpRT-LERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFG 288

                         90       100
                 ....*....|....*....|..
gi 754869839 248 DIRTLNTAFLKSYGVLPKEFRK 269
Cdd:COG4977  289 SASHFRRAFRRRFGVSPSAYRR 310
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
141-270 5.74e-12

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 65.08  E-value: 5.74e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 141 SLLLDRLLSISEYSILSSSEQNklmdlQERMERISSYIHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNK 220
Cdd:PRK13503 148 ILFMQLLVLLRKSSLQENGENS-----DARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNR 222

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 754869839 221 IRSEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLPKEFRKN 270
Cdd:PRK13503 223 LRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRDIRQG 272
PRK10371 PRK10371
transcriptional regulator MelR;
176-271 3.87e-10

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 59.83  E-value: 3.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 176 SYIHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKIRSEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTA 255
Cdd:PRK10371 198 GFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYST 277

                         90
                 ....*....|....*.
gi 754869839 256 FLKSYGVLPKEFRKNS 271
Cdd:PRK10371 278 FGKYVGMSPQQYRKLS 293
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
143-271 2.75e-08

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 54.21  E-value: 2.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 143 LLDRLLsISEYSILSSSEQnKLMDlqERMERISSYIHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKIR 222
Cdd:PRK10572 161 LLERLL-LRCMEAIPESLH-PPMD--PRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQR 236

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 754869839 223 SEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLPKEFRKNS 271
Cdd:PRK10572 237 ISRAKLLLQTTRMPIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRARC 285
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 178-219 3.03e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 43.30  E-value: 3.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 754869839  178 IHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLN 219
Cdd:pfam00165   1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
117-277 3.06e-06

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 47.98  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 117 LLLQAALSyfaddknnsLRTHGYTSlllDRLLSISEysilssSEQNKLMdlqerMERISSYIHENYDhkisLEMIASHEG 196
Cdd:PRK13501 151 LLLQLAIV---------LKRHRYRA---EQAHLLPD------GEQLDLI-----MSALQQSLGAYFD----MADFCHKNQ 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 197 LSRTYFSHFFKSNFGINFNEYLNKIRSEKARTLLSSSKDNLLNIAYMCGFSDIRTLNTAFLKSYGVLPKEFRKNSVLFPN 276
Cdd:PRK13501 204 LVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQRFIRSPV 283


                 .
gi 754869839 277 L 277
Cdd:PRK13501 284 L 284
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
28-82 5.11e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 44.45  E-value: 5.11e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 754869839  28 PHLHFDIELAFVLEGAGQVITQEQCFEIKAGQAIIFNSCQVHEL--SSSDSMKLLIL 82
Cdd:COG1917   38 WHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFrnLGDEPAVLLVV 94
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
171-268 2.32e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 45.05  E-value: 2.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 171 MERISSYIHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKIRSEKARTLLSSSKDNLLNIAYMCGFSDIR 250
Cdd:PRK13502 178 LDKLITALANSLECPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSN 257

                         90
                 ....*....|....*...
gi 754869839 251 TLNTAFLKSYGVLPKEFR 268
Cdd:PRK13502 258 YFSVVFTRETGMTPSQWR 275
ftrA PRK09393
transcriptional activator FtrA; Provisional
 171-270 5.76e-05

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 44.18  E-value: 5.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 171 MERISSYIHENydHKISLemIASHEGLS-RTYFSHFFKSNfGINFNEYLNKIRSEKARTLLSSSKDNLLNIAYMCGFSDI 249
Cdd:PRK09393 224 IDWMRAHLAEP--HTVAS--LAARAAMSpRTFLRRFEAAT-GMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSE 298

                         90       100
                 ....*....|....*....|.
gi 754869839 250 RTLNTAFLKSYGVLPKEFRKN 270
Cdd:PRK09393 299 ESLRHHFRRRAATSPAAYRKR 319
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 27-80 4.41e-04

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 38.01  E-value: 4.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 754869839   27 KPHLH-FDIELAFVLEGAGQVITQEQCFEIKAGQAIIFNSCQVHELS--SSDSMKLL 80
Cdd:pfam07883  12 PPHRHpGEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRFRntGDEPARLL 68
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
171-268 5.76e-04

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 40.86  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 171 MERISSYIHENYDHKISLEMIASHEGLSRTYFSHFFKSNFGINFNEYLNKIRSEKARTLLSSSKDNLLNIAYMCGFSDIR 250
Cdd:PRK13500 208 LDKLITRLAASLKSPFALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSN 287

                         90
                 ....*....|....*...
gi 754869839 251 TLNTAFLKSYGVLPKEFR 268
Cdd:PRK13500 288 YFSVVFTRETGMTPSQWR 305
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
28-86 7.33e-04

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 38.58  E-value: 7.33e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839  28 PHLHFDI-ELAFVLEGAGQVITQEQCFEIKAGQAIIFNSCQVHELSSSDSMKLLILQFSS 86
Cdd:COG0662   42 LHVHPHRdEFFYVLEGTGEVTIGDEEVELKAGDSVYIPAGVPHRLRNPGDEPLELLEVQA 101
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 25-120 4.65e-03

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 36.64  E-value: 4.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839   25 YRKPHLHFDIELAFVLEGAGQVITQEQCFEIKAGQAIIFNSCQVHELSSSDSM--KLLILQFSSEIFKIIfpQLDKIYFE 102
Cdd:pfam02311  15 SFPPHVHDFYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDgwRYRWLYFEPELLERI--LADISILA 92

                          90
                  ....*....|....*...
gi 754869839  103 NHPFNLKNQPETLKLLLQ 120
Cdd:pfam02311  93 GGPLPLLRDPELAALLRA 110
cupin_MAE_RS03005 cd06987
Microcystis aeruginosa MAE_RS03005 and related proteins, cupin domain; This family includes ...
 28-84 7.54e-03

Microcystis aeruginosa MAE_RS03005 and related proteins, cupin domain; This family includes bacterial and some eukaryotic proteins homologous to MAE_RS03005, a Microcystis aeruginosa protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380392 [Multi-domain]  Cd Length: 122  Bit Score: 35.70  E-value: 7.54e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 754869839  28 PHLH-FDIELAFVLEGAGQVITQEQCFEIKAGQAIIFNSCQVHELSSSDSMKLLILQF 84
Cdd:cd06987   43 PNTHpAAHEMFFVLAGEGRAYCDGQRVPLRPGDALVVPPGSEHVIENTGSGRLYCLTL 100
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 189-269 9.45e-03

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 37.32  E-value: 9.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754869839 189 EMIASHEGLS-RTYFSHFfkSNFGINFNEYLNKIRSEKARTLLSSSKDN--LLNIAYMCGFSDIRTLNTAFLKSYGVLPK 265
Cdd:PRK09685 218 EWIAGELGISvRSLYRLF--AEQGLVVAQYIRNRRLDRCADDLRPAADDekITSIAYKWGFSDSSHFSTAFKQRFGVSPG 295


                 ....
gi 754869839 266 EFRK 269
Cdd:PRK09685 296 EYRR 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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