|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
20-395 |
0e+00 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 622.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 20 MLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSID 99
Cdd:PRK11102 1 MLMPLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTID 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 100 QLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALLASA 179
Cdd:PRK11102 81 QLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 180 MIFFFIDETLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYYFALNI 259
Cdd:PRK11102 161 LVFFFIPETLPKERRQPFHLRTTIRNFASLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 260 VFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISSNAMAVILDEFPHMA 339
Cdd:PRK11102 241 VFLFVMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSALLDLGFWALVVGVAAFVGCVSMISSNAMAVILDEFPHMA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 754492089 340 GTASSLAGTFRFGIGAIVGALLSMATFTTAWPMLWAMAFCATSSVLFCLYASRPRK 395
Cdd:PRK11102 321 GTASSLAGTLRFGIGAIVGALLSLAPFTSAWPMVWSMAFCSILSILFYLYASRPKK 376
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
6-391 |
1.96e-142 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 410.24 E-value: 1.96e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 6 HSSFKIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVF 85
Cdd:TIGR00710 1 KSAKAFALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 86 AAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHA 165
Cdd:TIGR00710 81 ALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 166 IFWILALAALLASAMIFFFIDETLPVERRQkfHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNH 245
Cdd:TIGR00710 161 IFAFLSLAGILLSALIFFILPETLPYEARI--QISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 246 VSPQHFGYYFALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGC-VSMIS 324
Cdd:TIGR00710 239 VSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIgNSMIS 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754492089 325 SNAMAVILDEFPHMAGTASSLAGTFRFGIGAIVGALLSMATFTTAWPMLWAMAFCATSSVLFCLYAS 391
Cdd:TIGR00710 319 SIAMAYALEDFPHVAGTASALFGTLRLVLGAIVGYLVSLIHGNTAWPMSLSCLVLAVVSVLAFYYLS 385
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-390 |
3.49e-103 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 310.28 E-value: 3.49e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 12 VFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVA 91
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 92 CALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILA 171
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 172 LAALLASAMIFFFIDETLPVERRQKFhIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHF 251
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKPL-LSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 252 GYYFALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAFL-DVGFWALVIGVAAFVGCVSMISSNAMAV 330
Cdd:cd17320 240 GLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLgGLSLWPLVAPLFLIFFGFGLIFPNATSL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 331 ILDEFPHMAGTASSLAGTFRFGIGAIVGALLSMATFTTAWPMLWAMAFCATSSVLFCLYA 390
Cdd:cd17320 320 ALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-356 |
9.96e-46 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 160.52 E-value: 9.96e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 1 MTTRPHSSFKIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILG 80
Cdd:COG2814 1 MPATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 81 GTLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVW 160
Cdd:COG2814 81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 161 FSWHAIFWILALAALLASAMIFFFIDETLPVERRQKfhirttIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVY 240
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAARARL------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 241 IELNHVSPQHFGYYFALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAfldvGFWALVIGVAAFVGCV 320
Cdd:COG2814 235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG----SLWLLLLALFLLGFGF 310
|
330 340 350
....*....|....*....|....*....|....*..
gi 754492089 321 SMISSNAMAVILDEFP-HMAGTASSLAGTFRFGIGAI 356
Cdd:COG2814 311 GLLFPLLQALVAELAPpEARGRASGLYNSAFFLGGPL 347
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
8-373 |
8.77e-35 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 132.32 E-value: 8.77e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 8 SFKIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAA 87
Cdd:PRK11043 4 SKGFLVYLAGLSMLGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFAL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 88 AAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIF 167
Cdd:PRK11043 84 GSLGMLWVESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 168 WILALAALLASAMIFFFidetlpVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHvS 247
Cdd:PRK11043 164 ATLFAITLLLILPTLRL------KPSKKARKQSQDALTFKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFILEQMGY-S 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 248 PQHFGYYFALNIVfLFVLTIINSR-FVRRVGALNMFR--AGLWIQFVMAVWLvVSAFLDVGFWALVIGVAAFVGCVSMIS 324
Cdd:PRK11043 237 PADIGLSYVPQTI-AFLVGGYGCRaALQKWGGEQLLPwlLVLFAVSVIAIWL-ASLLSHPSLVPLLIPFCVMAAANGAIY 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 754492089 325 SNAMAVILDEFPHMAGTASSLAGTFR----FGIGAIVGALLSMATFTTAWPML 373
Cdd:PRK11043 315 PIVVAQALRPFPQATGKAAALQNTLQlglcFLASLLVSALISTPLLTTGSVML 367
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
4-362 |
4.24e-34 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 130.41 E-value: 4.24e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 4 RPHSSFKIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTL 83
Cdd:PRK11652 2 KRQRNVNLLFMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 84 VFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSW 163
Cdd:PRK11652 82 IFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGW 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 164 HAIFWILALAALLASAMIFFFIDETLPVERRQkfhiRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIEL 243
Cdd:PRK11652 162 RACYLFLLLLGAGVTFSMARWMPETRPADARR----TRVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 244 NHVSPQHFGYYFALNIVFLFVLTIINSRFVRRVGALnMFRAGLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMI 323
Cdd:PRK11652 238 LGLSSMTVSILFILPIPAAFFGAWFAGRPNKRFSTL-MWQSVICCLLAGLLMWIPGWFGVMNVWTLLVPAALFFFGAGML 316
|
330 340 350
....*....|....*....|....*....|....*....
gi 754492089 324 SSNAMAVILDEFPHMAGTASSLAGTFRfGIGAIVGALLS 362
Cdd:PRK11652 317 FPLATSGAMEPFPYLAGTAGALLGGLQ-NIGSGLAALLS 354
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-386 |
1.11e-30 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 120.76 E-value: 1.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 15 LGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACAL 94
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 95 AQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAA 174
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 175 LLASAMIFFFIDETLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYY 254
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 255 FALNIVFLFVLTIINSRFVRRVGALNMFRAGLwiqFVMAVWLVVSAFLDvGFWALVIGVAAFVGCVSMISSNAMAVILDE 334
Cdd:cd17325 241 FGAQGLASALSQPPAGKLSDRIGRKPLILIGL---LLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 754492089 335 FPHMA-GTASSLAGTFrFGIGAIVGALLS---MATFTTAWPMLWAMAFCATSSVLF 386
Cdd:cd17325 317 VPPEGrGTAMGLFNTA-FSLGMVLGPLLGgflYDAFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
12-356 |
1.62e-30 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 120.37 E-value: 1.62e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 12 VFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVA 91
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 92 CALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILA 171
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 172 LAALLASAMIFFFidetLPVerrqkfhirttignfaslfrhkrVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHF 251
Cdd:cd17323 161 IISGFCLILIFLF----LPI-----------------------VLLLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEV 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 252 GYYFALNIVFLFVLTIINSRF--------VRRVGALNMFRAGLWIQFVMAVWLVVSAFL-------DVGFWALVIGVAAF 316
Cdd:cd17323 214 GLMYLPIGIGALIGSIIGGRLsdyyyrrlKKKNGGKPEPEARLPPAFIGAFLFPIGLFIfgwtiypHIHWIVPIIGSAFF 293
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 754492089 317 VGCVSMISSNAMAVILDEFPHMAGTASSLAGTFRFGIGAI 356
Cdd:cd17323 294 GFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAI 333
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
12-362 |
5.70e-27 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 110.35 E-value: 5.70e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 12 VFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVA 91
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 92 CALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAvLVWFSWHAIFWILA 171
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL-LAAISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 172 LAALLASAMIFFFIDETLPVERRQKFhirTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHF 251
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSA---TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIII 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 252 GYYFALNIVFLFVLTIINSRFV-RRVGALNMFRAGLwiqFVMAVWLVVSAFLDvGFWALVIGVAAFVGCVSMISSNAMAV 330
Cdd:cd17474 237 GLLFAGWSVLLALGSLFVGRLLkKRFGARRILVIGL---LLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTL 312
|
330 340 350
....*....|....*....|....*....|...
gi 754492089 331 ILDEFP-HMAGTASSLAGTFRFgIGAIVGALLS 362
Cdd:cd17474 313 VTELAPeEERGTASSLYNFVRF-LGQAVGPLLF 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
12-378 |
1.23e-26 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 109.56 E-value: 1.23e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 12 VFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVA 91
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 92 CALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILA 171
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 172 LAALLASAMIFFFidetLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHF 251
Cdd:cd17324 161 VLALLAALLLWRL----LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 252 GYYFALnivfLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISSNAMAVI 331
Cdd:cd17324 237 IGLLLL----FGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 754492089 332 LDEFPHMAGTASSLAGTFRFGIGAIVGALLSMATFTTAWPMLWAMAF 378
Cdd:cd17324 313 LRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGA 359
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
17-398 |
2.09e-25 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 106.26 E-value: 2.09e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 17 LLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQ 96
Cdd:PRK10473 10 ALVLLYPAGIDMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 97 SIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALL 176
Cdd:PRK10473 90 TSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLFYTMAAMGIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 177 ASAMIFFFIDETLPVerrQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYYFA 256
Cdd:PRK10473 170 VLLLSLFILKETRPA---RAPAASSKPRENSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMGFSRGEYAIIMA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 257 LN------IVFL--FVLTIINSRFVRRVGALNMFRAGLwiqFVMAVWLvvSAFLDVGFWALVIGVAAFVGCvsmissnAM 328
Cdd:PRK10473 247 LTagvsmtVSFStpFALGIFKPRTLMLTSQVLFLAAGI---TLALSPS--HAVSLFGITLICAGFSVGFGV-------AM 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 329 AVILDEFPHMAGTASSLAGTFRFGIGAIVGALLSMATFTTAWPMLWAMAFCATSSVLFCLYASRPRKAAH 398
Cdd:PRK10473 315 SQALGPFSLRAGVASSTLGIAQVCGSSLWIWLAAVLGISAWNMLIGILIACSIVSLLLILFVAPGRPVAA 384
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
11-398 |
2.28e-25 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 106.12 E-value: 2.28e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 11 IVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAV 90
Cdd:COG2223 6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 91 ACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWIL 170
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 171 ALAALLASAMIFFFIDETLPVERRQKfhiRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQH 250
Cdd:COG2223 166 GILLLVVAVLAWLFLRDPPAGAAAAA---KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 251 FGYYFALNIVFLFVLTIINSRFVRRVGALNMFragLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISSNAMAV 330
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVL---LIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFAL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 754492089 331 ILDEFP-HMAGTASSLAGTFrFGIGAIVG----ALLSMATFTTAWPMLWAMAFCATSSVLFCLYASRPRKAAH 398
Cdd:COG2223 320 VPDIFPtKNAGAVYGLVGAA-GGLGGFLGpllfGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRRAAA 391
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
15-369 |
2.29e-25 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 105.72 E-value: 2.29e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 15 LGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACAL 94
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 95 AQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAA 174
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 175 llasamifffidetlpverrqkfhirttignFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYY 254
Cdd:cd17321 161 -------------------------------LVALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 255 FALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVmAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISSNAMAVILDE 334
Cdd:cd17321 210 LLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV-GLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSS 288
|
330 340 350
....*....|....*....|....*....|....*.
gi 754492089 335 FP-HMAGTASSLAGTFRFgIGAIVGALLSMATFTTA 369
Cdd:cd17321 289 VPkEKAGAASGILNTARQ-LGGALGVALLGALLTAG 323
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-188 |
2.49e-25 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 100.03 E-value: 2.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 52 STYILGFALGQLLYGPMA----DSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIY 127
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754492089 128 PKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALLASAMIFFFIDET 188
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
15-356 |
7.35e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 104.04 E-value: 7.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 15 LGLLAMLMPLSIDMYLPALP-VISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACA 93
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 94 LAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALA 173
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 174 ALLASAMIFFFIDETLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPfVYIELNHVSPQHFGY 253
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 254 YFALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISSNAMAVILD 333
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDL 319
|
330 340
....*....|....*....|...
gi 754492089 334 EFPHMAGTASSLAGTFRFGIGAI 356
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGAL 342
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
15-224 |
7.00e-24 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 102.32 E-value: 7.00e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 15 LGLLAMLMPLSI-----------DMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTL 83
Cdd:PRK15402 7 LGRQALLFPLCLvlfefatyianDMIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 84 VFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSW 163
Cdd:PRK15402 87 FFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPW 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754492089 164 HAIFWILALAALLASAMIFFFIDETLpVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGF 224
Cdd:PRK15402 167 RGMFVLFAALAALSFFGLWRAMPETA-GRVGEKLSLKELGRDYKLVLKNRRFVAGALALGL 226
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
2-296 |
6.62e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 94.88 E-value: 6.62e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 2 TTRPHSSFKIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGG 81
Cdd:COG0477 6 AAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 82 TLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWF 161
Cdd:COG0477 86 LLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 162 SWHAIFWILALAallasAMIFFFIDETLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYI 241
Cdd:COG0477 166 GWRWIFLINAPL-----GLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 754492089 242 ELNHVSPQHFGYYFALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWL 296
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-386 |
5.55e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 87.62 E-value: 5.55e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 1 MTTRPHSSFKIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILG 80
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 81 GTLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVW 160
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 161 FSWHAIFWILALAALLASAMIFFFIdetlpverrqkfhirttignfaslfrhkrvlsyMLASGFSFAGMFSFLSAGPFVY 240
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRFWLL---------------------------------ALAYFLVYFALYGFLTWLPTYL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 241 IELNHVSPQHFGYYFALNIVFLFVLTIINSRFVRRVGALNMfRAGLWIQFVMAVWLVVSAFLDvGFWALVIGVAAFVGCV 320
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRK-LVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754492089 321 SMISSNAMAVILDEFP-HMAGTASSLAGTFRFGIGAI----VGALLSMATFTTAWPMLWAMAFCATSSVLF 386
Cdd:COG2271 286 GGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALgpllVGYLLDATGYQAAFLLLAALALLAALLALL 356
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
15-363 |
6.66e-19 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 87.25 E-value: 6.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 15 LGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACAL 94
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 95 AQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAA 174
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 175 LLASAMIfffidetlPVERrqkfhirttignfASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYY 254
Cdd:cd17503 161 ILALLLA--------PLLD-------------LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLV 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 255 FALNIVFLFVLTIINSRFVRRVGALNMFRAGLwIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISSNAMAVILDE 334
Cdd:cd17503 220 LAPGGLASAILSPLVGRLLDKFGPRLLLLAGL-LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNS 298
|
330 340 350
....*....|....*....|....*....|
gi 754492089 335 FP-HMAGTASSLAGTFRFGIGAIVGALLSM 363
Cdd:cd17503 299 LPpEQIGDATALFNTIRQLGGSIGTALLAT 328
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
13-390 |
3.37e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 82.24 E-value: 3.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 13 FILGLLAMLMPLSIDMYLPALPVISAQF-GVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVA 91
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 92 CALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAvLVWFSWHAIFWILA 171
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGA-LAEIGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 172 LAALLASAMIFFfidetLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHF 251
Cdd:cd17473 161 LALPVLILVLLF-----LPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 252 GYYFALNIVFLFVLTIINSRFVRRVGALNMFRAGLwiqFVMAVWLVVSAFldVGFWALVIGVAAFVGC-VSMISSNAMAV 330
Cdd:cd17473 236 GLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF---ALMALGFLLLAL--ASGLWVVLLGAILAGLgFGLLLPTLNSW 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754492089 331 ILDEFP-HMAGTASSLAGTFRFG---IGAIVGALLSMATFTTAWPMLWAMAFCATSSVLFCLYA 390
Cdd:cd17473 311 AMSLVPpELRGRAMGIVTSAFFLgqfLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
24-274 |
4.37e-17 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 82.18 E-value: 4.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 24 LSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLII 103
Cdd:PRK15403 30 LTTDLIQPGIINVVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 104 MRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALLASAMIFF 183
Cdd:PRK15403 110 ARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 184 FIDETLPVERRQkFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYYFALNIVFLF 263
Cdd:PRK15403 190 AMPETVKRGAVP-FSAKSVLRDFRNVFRNRLFLTGAATLSLSYIPMMSWVAVSPVILIDAGGMTTSQFAWTQVPVFGAVI 268
|
250
....*....|.
gi 754492089 264 VLTIINSRFVR 274
Cdd:PRK15403 269 VANAIVARFVK 279
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-389 |
1.03e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.93 E-value: 1.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 15 LGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACAL 94
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 95 AQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVW--FSWHAIFWILAL 172
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 173 AALLASAMIFFFIDET--LPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQH 250
Cdd:cd06174 161 LALLAAILLLLVVPDPpeSARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 251 FGYYFALNIVFLFVLTIINSRFVRRVGALnmfRAGLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISSNAMAV 330
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGR---KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 331 ILDEFP-HMAGTASSLAGTFRFGIGAIVGALLSMATFTTAWPMLWAMAFCATSSVLFCLY 389
Cdd:cd06174 318 IAELFPpEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-397 |
1.61e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 80.28 E-value: 1.61e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 10 KIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAA 89
Cdd:COG0738 8 RALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 90 VACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPkEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVW---FSWHAI 166
Cdd:COG0738 88 LLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGP-ETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 167 FWILALAALLASAMIFFFideTLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHV 246
Cdd:COG0738 167 YLILAVLLLLLALLFLRS---KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 247 SPQHFGYYFALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAfldvGFWALVIGVAAFVGCVSMISSN 326
Cdd:COG0738 244 SEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP----GPWLALIGLALVGLGLSLMFPT 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 754492089 327 AMAVILDEFPHMAGTASSLAGTFRFGIGAIVGALLS-MATFTTAWPMLWAMAFCATSSVLFCLYASRPRKAA 397
Cdd:COG0738 320 IFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGfLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
24-362 |
1.77e-16 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 79.95 E-value: 1.77e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 24 LSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLII 103
Cdd:cd17489 10 LSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 104 MRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALLASAMIFF 183
Cdd:cd17489 90 LRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 184 FIDETLPVERRQKFHIRttignFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPqhfGYYFALNIVFLF 263
Cdd:cd17489 170 VKDPPPVAAEEAEAGTR-----AFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISNA---GLFFTVYAIALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 264 VLTIINSRFVRRVGALNMFRAGLwiqFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISSNAMAVILDEFPHMAGTAS 343
Cdd:cd17489 242 LSRPFSGKLSDRKGPKTVIIPGL---LLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAAN 318
|
330 340
....*....|....*....|..
gi 754492089 344 SLAGTFR---FGIGAIVGALLS 362
Cdd:cd17489 319 GTFFIFFdlgIGLGGLLLGLVA 340
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
2-189 |
5.96e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 72.77 E-value: 5.96e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 2 TTRPHSSF-KIVFILGLLAMLMP-LSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVIL 79
Cdd:TIGR00895 7 RKQPLSRYqWRAIILSFLIMLMDgYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 80 GGTLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLV 159
Cdd:TIGR00895 87 WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIP 166
|
170 180 190
....*....|....*....|....*....|
gi 754492089 160 WFSWHAIFWILALAALLASAMIFFFIDETL 189
Cdd:TIGR00895 167 VFGWRSLFYVGGIAPLLLLLLLMRFLPESI 196
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-392 |
1.29e-13 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 71.49 E-value: 1.29e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 28 MYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILG-----GTLVFAAAAVACALAQSIDQLI 102
Cdd:cd06173 17 IFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 103 IMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALLASAMIF 182
Cdd:cd06173 97 VLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 183 FF-IDETLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYYFALNIVF 261
Cdd:cd06173 177 FIrRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 262 LFVLTIINSRFVRRVGALNMFRAGLwiqFVMAVWLVVSAFldVGFWALVIGVAAFVGCVSMISSNAMAVILDEF--PHMA 339
Cdd:cd06173 257 ALLGALLLGRLSKRRRRGRLLLIGA---LLLGLALLVLGL--SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRvpDELR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 754492089 340 GTASSLAGTfrFGIGAIVGALLSMATFTTAWPMLWAMAFCATSSVLFCLYASR 392
Cdd:cd06173 332 GRVFSVYNA--LNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
33-362 |
3.02e-13 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 70.32 E-value: 3.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 33 LPVISAqFGVPAGSAQMTLSTYILG-FALGQLL----YGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFL 107
Cdd:cd17472 16 LPVLSV-YAKSLPGATPTLIGLALGiYGLTQAIfqipFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRAL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 108 HGLAAAAAsvVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVApMAGGAVLV-WFSWHAIFWILALAALLASAMIFFFId 186
Cdd:cd17472 95 QGSGAISS--VVMALLADLTREENRTKAMALIGASIGIAFAIS-MVLGPLLAaHLGVSGLFLITAILSLVSLLILLFFV- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 187 etlPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFgYYFALNIVFLFVLT 266
Cdd:cd17472 171 ---PDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLW-KVYLPAILIGFILM 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 267 IINSRFVRRVGAlnMFRAGLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFvgcvsMISSNAMAVILDEF------PHMAG 340
Cdd:cd17472 247 VPFVIYAEKKGK--MKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIF-----FIGFNLLEALLPSLvskiapKEYRG 319
|
330 340
....*....|....*....|..
gi 754492089 341 TASSLAGTFRFgIGAIVGALLS 362
Cdd:cd17472 320 TAMGIYNTSQF-LGSFLGGALG 340
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-369 |
4.28e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 67.23 E-value: 4.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 1 MTTRPHSSFKIVFILGLLAMLMPLSIDMYLPALPVI-SAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLG-----R 74
Cdd:COG2211 1 TAAKKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFyTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 75 KPVILGGTLVFAAAAVACALAQSIDQ------LIIMRFLHGLAAAAASVVINALMRDIYP-KEEFSRMMSFVMLVTTIAP 147
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPtgkliyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 148 LVAPMAGGAVLVWFS------WHAIFWILALAALLASAMIFFFIDETLPVERRQKfhirTTIGNFASLFRHKRVLSYMLA 221
Cdd:COG2211 161 LLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKV----SLKESLKALLKNRPFLLLLLA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 222 SGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYYFALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAF 301
Cdd:COG2211 237 YLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGP 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 754492089 302 LDVGFWALVIGVAAFVGCVSMISSNAM---AVILDEFPHMAGTASSLAGTFRFGI-------GAIVGALLSMATFTTA 369
Cdd:COG2211 317 GNLWLLLVLAALAGIGLGAILVLPWAMladVVDYDEWKTGRRREGLYFGIFTFAIklgqalaGALAGLLLALFGYVAG 394
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
36-380 |
5.74e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 66.48 E-value: 5.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 36 ISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAA 115
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 116 SVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGaVLVWFSWHAIFWILALAALLASAMIFFFIDETLPVERRQ 195
Cdd:cd17329 106 EPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGG-LLLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 196 kfHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYYFALNIVFLFVLTIINSRFVRR 275
Cdd:cd17329 185 --EKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVER 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 276 VGALNMFRAGLwiqFVMAVWLVVSAFLdVGFWALVIGVAAF-VGcvSMISSNAMAVILDEF--PHMAGT---ASSLAGTF 349
Cdd:cd17329 263 FRLRKILMIGI---LLFAIGFAVLAFA-NTLAVLILAMIVLtLG--EMLVFPAVQTLVAALapPDKRGSymgFYALAWGL 336
|
330 340 350
....*....|....*....|....*....|..
gi 754492089 350 RFGIG-AIVGALLSMATFTTAWPMLWAMAFCA 380
Cdd:cd17329 337 GRAIGpLVGGLLLDLLGPGLPWLILAALGLIA 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
32-169 |
9.64e-12 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 65.66 E-value: 9.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 32 ALPVISAQFGvPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLA 111
Cdd:cd17502 18 ALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIG 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 754492089 112 AAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWI 169
Cdd:cd17502 97 GGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI 154
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
32-194 |
9.75e-11 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 63.17 E-value: 9.75e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 32 ALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLA 111
Cdd:TIGR00711 24 AIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 112 AAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALLASAMIFFFIDETLPV 191
Cdd:TIGR00711 104 GGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPA 183
|
...
gi 754492089 192 ERR 194
Cdd:TIGR00711 184 ASE 186
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
15-365 |
9.83e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 62.60 E-value: 9.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 15 LGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACAL 94
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 95 AQSIDQLIIMRFLHGLAAAAASVVInALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAA 174
Cdd:cd17504 81 APNLPVLIAGRALQGIGGAVFPLAF-ALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 175 LLASAMIfFFIDetlpverrqkfhirttignfASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVyielnHVSPQHFGYY 254
Cdd:cd17504 160 VLLAALV-PLID--------------------LRLLRRRNVLLANITALLAGFGMFMVFQLLPQL-----LQLPTPTGFG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 255 FALNIVFL---------FVLTIINSRFVRRVGALNMFRAGLwiqFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISS 325
Cdd:cd17504 214 LGITEAGLlllpgalvmLIAGPLAGRLIARVGPRRVLLIGL---VISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFA 290
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 754492089 326 NAMAVILDEFP-HMAGTASSLAGTFRF---GIG-AIVGALLSMAT 365
Cdd:cd17504 291 SLPNIVVESVPpDRTGIATGMNTVLRTigsAIGpAIAGAILTTYT 335
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
32-386 |
2.09e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.82 E-value: 2.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 32 ALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLA 111
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 112 AAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALLASAMIFFFIdetlpv 191
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 192 errqkfhirttignfaslfrhKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYYFALNIVFLFVLTIINSR 271
Cdd:cd17319 179 ---------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGR 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 272 FVRRVGALNMFRAGLWIQFVMAVWLVVSAFLDvGFWALVIGVAAFVGCVSMISSNAMAVILDEFP-HMAGTASSLAGTFr 350
Cdd:cd17319 238 LSDRLLRGARRLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSG- 315
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 754492089 351 FGIGAIVGALL------SMATFTTAWPMLWAMAFCATSSVLF 386
Cdd:cd17319 316 GNLGGFVAPLLigylvdATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
17-386 |
5.57e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 60.26 E-value: 5.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 17 LLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQ 96
Cdd:cd17477 3 LSVALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 97 SIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVwfSWHAIFWILALAALL 176
Cdd:cd17477 83 SPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGT--AGALPFLIAAVLLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 177 ASAMIFFFIDETLPVERRQKFHIRTTIgnfaslFRHKRVLSYMLASGFSFAGMFSFLSagpfVYIELNHVSPQHFGYYFA 256
Cdd:cd17477 161 ALVPLLLTRRAAPEIEEAESISLRRLL------RIAPLALLGAFVAGFLEGAFYSLLP----LYGLRLGLSVAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 257 L----NIVFLFVLTIINSRFVRRvgalnmfRAGLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISSNAMAVIL 332
Cdd:cd17477 231 AfvlgGLLLQWPLGWLADRFDRR-------RVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAG 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 754492089 333 DEFPHMAGTASSLAGTFRFGIGAIVGALLSMATFTTAWP--MLWAMAFCATSSVLF 386
Cdd:cd17477 304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPhgLFLFLAAVALLFLLF 359
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
24-388 |
1.35e-09 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 59.11 E-value: 1.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 24 LSIDMY----LPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSID 99
Cdd:cd17478 6 FLNDFYqgflPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 100 QLIIMRFLHGLAAAA----ASVVINALmrdiyPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAAL 175
Cdd:cd17478 86 LLLLLVALAGIGSAAfhpeGARLASQA-----AGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 176 LASAMIFFFIDETLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSagpfVYIELNHVSPQHFGYYF 255
Cdd:cd17478 161 AVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLP----FYLVQRGYSLVFAGLLL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 256 ALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWlvvsaFLDVGFWALVIGVAAFVGCVSMISSNAMAVILDEF 335
Cdd:cd17478 237 SLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLL-----FLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 754492089 336 PHMAGTASSLAGTFRFGIGAIVGALL-SMATFTTAWPMLWAMAFCATSSVLFCL 388
Cdd:cd17478 312 PGNVGLASGLMMGLSFGLGGIGAPVLgALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
12-385 |
1.84e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 58.77 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 12 VFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQ--MTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAA 89
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQtgLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 90 VACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEE----FSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHA 165
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRrgfaLGLLQSGWALGALLAALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 166 IFWIlalaallasamifffidetlpverrqkfhirTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNH 245
Cdd:cd17316 161 LFLI-------------------------------GALPALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 246 VSPQHFGYYFALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVsaFLDVGFWALVIGVAAFVGCVSMISS 325
Cdd:cd17316 210 LSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFY--LLSGSPTLLLLLLFILSFFVGGVWG 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754492089 326 NAMAVILDEFP-HMAGTASSLA---GTFRFGIGAIVGALLSMATFTTAWPMLWAMAFCATSSVL 385
Cdd:cd17316 288 ALYAYLAELFPtEVRATGVGLSynlGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIV 351
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
66-185 |
3.71e-09 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 58.04 E-value: 3.71e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 66 GPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTI 145
Cdd:cd17391 261 GKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYL 340
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 754492089 146 APLVAPMAGGAVLVWFSWHAIFWILALAALLASAMIFFFI 185
Cdd:cd17391 341 GNVAGPLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
2-397 |
4.12e-09 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 57.96 E-value: 4.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 2 TTRPHSSFKIVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGG 81
Cdd:COG2807 10 RSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 82 TLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKeEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWF 161
Cdd:COG2807 90 LLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAAL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 162 SWHAIFWILALAALLasAMIFFFIdetLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYI 241
Cdd:COG2807 169 GWRGALAVWALLALL--ALLLWLP---LLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILR 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 242 ELnHVSPQHFGYYFAL----NIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAFLdvgFWALVIGVAAfV 317
Cdd:COG2807 244 DA-GLSAATAGLLLSLfqlaGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPW---LWAVLLGLGQ-G 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 318 GCVSMissnAMAVILDEFPHMAGTASSLAGTFRFG-IGAIVGALLS--MATFTTAW-PMLWAMAFCATSSVLFCLYASRP 393
Cdd:COG2807 319 GLFPL----ALTLIGLRARTPAEAAALSGMAQSVGyLLAALGPLLVgaLHDATGSWtAALLLLAALAVLMLVAGLLAGRP 394
|
....
gi 754492089 394 RKAA 397
Cdd:COG2807 395 YVED 398
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
12-185 |
4.43e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 4.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 12 VFILGLLAMLMPLSIDMYLPALPV-ISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAV 90
Cdd:cd17325 201 LLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 91 ACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWIL 170
Cdd:cd17325 281 LLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAA 360
|
170
....*....|....*
gi 754492089 171 ALAALLASAMIFFFI 185
Cdd:cd17325 361 AALLLLAAVLFLLLR 375
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
32-169 |
1.09e-08 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 56.66 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 32 ALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLA 111
Cdd:PRK10504 32 ALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVG 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 754492089 112 AAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWI 169
Cdd:PRK10504 112 GAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLI 169
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
28-296 |
1.71e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 55.77 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 28 MYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFL 107
Cdd:cd17371 17 LLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 108 HGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHaIFWILALAALLASAMIFFFIDE 187
Cdd:cd17371 97 AGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPE-IAWRVLFLLGALPALLVLFIRR 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 188 TLPVerrqkfhirttignfASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELnHVSPQHFGYYFALNIVFLFVLTI 267
Cdd:cd17371 176 FVKE---------------PPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASL-LATGALGGYYGITTWLPSYLTGE 239
|
250 260
....*....|....*....|....*....
gi 754492089 268 INSRFVRRVGALNMFRAGLWIQFVMAVWL 296
Cdd:cd17371 240 RGLSFEGSAGYLVVTILGGFLGYLAGGFL 268
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
33-312 |
6.81e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.86 E-value: 6.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 33 LPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLAA 112
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGA 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 113 AAASVVINALMRDIYPkEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVW-FSWHAIFWILALAALLASAMIFFFIDETLPV 191
Cdd:cd17333 99 GILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLIIGLIYLLLAILILLTLFPELPS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 192 ERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYYFALNIVFLFVLTIINSR 271
Cdd:cd17333 178 ARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGP 257
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 754492089 272 FVRRVGALNMFRAGLWIQFVMAVWLVVSAFLDVGFWALVIG 312
Cdd:cd17333 258 ISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALL 298
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
32-386 |
2.53e-07 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 52.18 E-value: 2.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 32 ALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLA 111
Cdd:cd17359 23 ALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 112 AAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVA--------PMAGGAVLVWFSWHAIFWIlalaaLLASAMIFF 183
Cdd:cd17359 103 VGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAyivnyliaNAGGADWLGAEGWRWMLGL-----EAIPAILFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 184 FIDETLPVERRQKFHIRTTIgnfaslfrhkRVLSYMLASGFSFAGMFSFLSAGPFVYIELNhVSPQHFGYYFALNIVFLF 263
Cdd:cd17359 178 LGMLFIPESPRWLVSKGKPI----------LIIGIGLAIFQQFVGINVIFYYGPEIFQNAG-FSENAALLQTIGIGVVNV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 264 VLTIINSRFVRRVGALNMFRAGLWIQ----FVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMISSNAMAVILDE-FP-H 337
Cdd:cd17359 247 IFTIIAILLVDKVGRKPLLLIGSIGMaislLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSWGPVTWVLLSEiFPnR 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 754492089 338 MAGTASSLAGTFRFGIGAIVGAL--LSMATFTTAWPMlWAMAFCATSSVLF 386
Cdd:cd17359 327 IRGLAMGIAVFFLWIANFLVSLTfpILLAAFGLAFTF-LIFAVICVLAFLF 376
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
31-392 |
3.02e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 51.89 E-value: 3.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 31 PALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGL 110
Cdd:cd17312 24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 111 AAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALLASAMIFFFIDETLP 190
Cdd:cd17312 104 FQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 191 VerrqkfhirttignfaslfrhkrVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYYFALNIVFLFVLTIINS 270
Cdd:cd17312 184 Y-----------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 271 RFVRRV------------GALNMFRAGLWIQFVMAVWLVVSAFLDVGFwalvigvaaFVGCVSMISSNAMAVILdeFPHM 338
Cdd:cd17312 241 LLSDKLfggrrapiaviyMLLMTLSLALFWFFPHNKLLSIVLLFLIGF---------FVGGPINLIGGAAAQDI--GRKE 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 754492089 339 A-GTASSLAGTFRFgIGAIVGALLSmATFTTAWPMLWAMAFCATSSVLFCLYASR 392
Cdd:cd17312 310 AaGTATGFVGLFGY-LGASLAGLPL-GYIIDHYGWSTVFYFLISAALLSVLLLLS 362
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
12-385 |
6.95e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.66 E-value: 6.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 12 VFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVA 91
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 92 CALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWIla 171
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLL-- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 172 laallasamifffidetlpverrqkfhirttiGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVspqhf 251
Cdd:cd17365 159 --------------------------------GGVPPLILLPLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEA----- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 252 GYYFALNIVFLFVLTI-------INSRFVRRVGAlnmFRAGLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGCVSMIS 324
Cdd:cd17365 202 GYSLSQALTITLLLNIggvigslLLGWLADRFGP---KRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQ 278
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 754492089 325 SNAMAVILDEFP-HMAGTA-SSLAGTFRFGigAIVGALLSMATFTTAWPMLWAMAFCATSSVL 385
Cdd:cd17365 279 VGLYALAARFYPtEVRATGvGWALGVGRLG--AILGPLLGGLLLAAGLGPESVFLALAIPAAL 339
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
11-311 |
8.11e-07 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 50.71 E-value: 8.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 11 IVFILgLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGP----MADSLGRKPVILGGTLVFA 86
Cdd:cd17388 1 LIFIL-VTVLLDAMGIGLIMPVLPTLLREFVGDSADAATHYGVLLALYALMQFIFAPilgaLSDRFGRRPVLLLSLAGAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 87 AAAVACALAQSIDQLIIMRFLHGLAAAAASVViNALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGaVLVWFSWHAI 166
Cdd:cd17388 80 LDYLLMAFAPTLWWLYLGRIIAGITGATGAVA-AAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGG-LLGEISPRAP 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 167 FWILALAALLASAMIFFFIDETLPVERRQKFHIRT--TIGNFASLFRHKrVLSYMLASGFSFaGMFSFLSAGPFVY--IE 242
Cdd:cd17388 158 FLVAAGLNGLNFLLGLFVLPESLPPERRRAFRWRRanPFGSLRWLTGFP-GLLGLLAVFFLI-QLIGQVPATTWVLftED 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 243 LNHVSPQHFGYYFA-LNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQfvmAVWLVVSAFLDVGFWALVI 311
Cdd:cd17388 236 RFDWSPTMVGLSLAvFGLLHALFQAFVTGPIAKRLGEKRAILLGLAAD---ALGFLLLAFATQGWMVFPI 302
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
17-375 |
8.52e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 50.27 E-value: 8.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 17 LLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMT---LSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACA 93
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVgllQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 94 LAQSIDQLIIMRFLHGLaAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALA 173
Cdd:cd17330 83 LSRNLWLLFLARFLDGL-TGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 174 ALLASAMIFFFIdetlpverrqkfhirttignfaslfrhkRVLSYMLASGFSFAGMFSFLSAGPFVYIELN-HVSPQHFG 252
Cdd:cd17330 162 ALLNLVLVLFFL----------------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRfGFSPSQIG 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 253 YYFALN-IVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAFLDVGFWALVIgVAAFVGCV--SMISSNAMA 329
Cdd:cd17330 214 LLLALVgIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAI-LAFGTGIVfpALSALLSKS 292
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 754492089 330 VILDEFPHMAGTASSLAGTFRFgIGAIVGALLSMATFTTAWPMLWA 375
Cdd:cd17330 293 VPSKEQGKAQGIIQSLQSLARI-IGPLLAGPLYSFLGPGVPFLLAA 337
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
26-222 |
2.19e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.54 E-value: 2.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 26 IDMYLPA--LPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLII 103
Cdd:cd17328 13 MDRFTIAgvLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 104 MRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAV-LVWFSWHAIFWILALAALLASAMIF 182
Cdd:cd17328 93 FRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaQATGGWRWAFRVTGVLGVLLAILLL 172
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 754492089 183 FFIDETLPVERRQKFHIRTTIGNFASLFRH-KRVLSYMLAS 222
Cdd:cd17328 173 LFVREPPRGAAEGGVMAKSTATSFLADLKAlAKNPSFILST 213
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
25-222 |
2.43e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 49.15 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 25 SIDMYLPALPVISAQFGVPAGSA-----QMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSID 99
Cdd:PRK09874 29 AFSLVMPFLPLYVEQLGVTGHSAlnmwsGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIW 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 100 QLIIMRFLHGLAAAAASVViNALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALLASA 179
Cdd:PRK09874 109 QFLILRALLGLLGGFVPNA-NALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGLRPVFFITASVLFLCFL 187
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 754492089 180 MIFFFIDET-LPVERRQKFHIRTTignFASLFRHKRVLSYMLAS 222
Cdd:PRK09874 188 VTLFCIRENfQPVSKKEMLHMREV---VTSLKNPKLVLSLFVTT 228
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
32-370 |
3.00e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.91 E-value: 3.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 32 ALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLA 111
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 112 AAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIA-PLVAPMAGGAVLVWFSWHAIFWILALAALLASAMIF-------- 182
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGgGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFlllrdspq 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 183 ---------FFIDETLPVERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGY 253
Cdd:TIGR00881 177 scglppaeeMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 254 YFALNIVFLFVLTI-----INSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAFLdvgfwaLVIGVAAFV-GCVSMISSNA 327
Cdd:TIGR00881 257 AFTLYELGGLVGTLlagwlSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANP------LMDLICLFAlGFLVYGPQML 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 754492089 328 MAVILDEFPHM--AGTASSLAGTFRFGIGAIVGALLSMATFTTAW 370
Cdd:TIGR00881 331 IGVIASELAPKkaAGTAAGFVGFFAYLGGILAGLPLGYLADGFGW 375
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
15-232 |
1.46e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 46.83 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 15 LGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLG-RKPVILGGTLVFAAAAVACA 93
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGkRKLFIIIGLLFTVLASLIMI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 94 LAQSIDQLIIMRFLHGlAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWIlala 173
Cdd:cd17490 81 LFPSPWGLLIARFLSG-IAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLL---- 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 754492089 174 aLLASAMIFFFIDETLPVERRQKFHIRTTIGNFASLFRHKRVLSY----MLASGFSFAGMFSF 232
Cdd:cd17490 156 -AALAGVLGFILSLFIKEERREKKPVLTELKELLSVLKDKKLLFFsllaILQQMITFSTTFGF 217
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
31-184 |
2.60e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 46.08 E-value: 2.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 31 PALPVISAQFGvPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGL 110
Cdd:cd06179 19 AVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGI 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 754492089 111 aAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLV--WFSWHAIFWILALAALLASAMIFFF 184
Cdd:cd06179 98 -GAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYINAIFNALALILLFFF 172
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-169 |
1.04e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.14 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 10 KIVFILGLLAMLMPLSIDMYLPALPVISAQ-FGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAA 88
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 89 AVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFW 168
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367
|
.
gi 754492089 169 I 169
Cdd:cd06173 368 L 368
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
11-386 |
2.20e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.03 E-value: 2.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 11 IVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAV 90
Cdd:cd17355 4 VLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 91 ACALAQSIDQLIIMRFLHGLAAAAA-SVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWI 169
Cdd:cd17355 84 LLALATSLWQLYLLWGLLGGGGAGTlAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 170 LALAALLASAMIFFFIDETLPVERRQKFHIRTTIGNFASLFRHKRVLSY-MLASGFSFAGM-FSFLSAGPFVYIELNHVS 247
Cdd:cd17355 164 LALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFwLLALAFFLCGFaVVGLIVHLVPYLADRGIS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 248 PQHFGYYFALNIVFLFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAFLDVGFWALVIGVAAFVGcvSMISSNA 327
Cdd:cd17355 244 PAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWG--ATVPLTA 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 754492089 328 MAVILDEFPHMAGTASSL---AGTFRFGIGAIVGALLSMATFTTAWPMLWAMAFCATSSVLF 386
Cdd:cd17355 322 ALAARYFGARSYGTLFGLvfaPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
32-186 |
2.29e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 43.02 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 32 ALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLA 111
Cdd:cd17476 20 ILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLG 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 754492089 112 AAAASVVINALMRDIYPKEEFsRMMSFvMLVTTIAPL---VAPMAGGAVLVWFSWHAIFWILALAALLASAMIFFFID 186
Cdd:cd17476 100 PAFLLPNAMALLGRTYPPGPR-KNIVF-SLFGATAPLgfaLGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWTS 175
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
8-166 |
2.45e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.98 E-value: 2.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 8 SFKIVFILGLLAMLMPLSIDMYLPALPVISA-QFGVPAGSAQMTLSTY-ILGFALGQLLYGPMADSLGRKPVILGGTLVF 85
Cdd:cd17331 205 RLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMdFFGLTPEENGYLMSYAgVLGMVVQGLLVGPLTKRFGERSLLKLSVALL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 86 AAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHA 165
Cdd:cd17331 285 AIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTVSPTIGGALLQAYGFPS 364
|
.
gi 754492089 166 I 166
Cdd:cd17331 365 F 365
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
56-188 |
2.63e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 42.95 E-value: 2.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 56 LGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRM 135
Cdd:cd17358 52 LGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGAL 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 754492089 136 MSFVMLVTTIAPLVAPMAGGAVlvwfSWHAIFWIlALAALLASAMIFFFIDET 188
Cdd:cd17358 132 GSLNQLLVNIGILLGYVLGSFL----PWRTLALI-GAIPPVVFLILLFFIPES 179
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
74-388 |
2.83e-04 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 2.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 74 RKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIY---PKEEFSRMMSFVMLVTTIAPLVA 150
Cdd:cd17471 62 RKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYAdrsSGRDATLFNSVLRAAFSLAWVIG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 151 PMAGGAVLVWFSWHAIFWILALAALLASAMIFFFIDetlpvERRQKFHIRTTIGNFASLFRHKRVLSYMLASGFSFAGMF 230
Cdd:cd17471 142 PPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLP-----SVKPPAQKATPASSLVKAPVNRRLLLLFAAFTLLFAANS 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 231 SFLSAGPFVYIELNHVSPQHFGYYFALNIVFLFVLTIINSRFVRRVGALNMFRAGlwiqFVMAVWLVVSAFLDVGFWALV 310
Cdd:cd17471 217 MYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAG----FLAGVLFYLGLALATSLWQLI 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 311 IGV---AAFVGcvsMISSNAMAVILDEFPHMAGTASSL-AGTFRfgIGAIVGALLsMATFTTAWPMLWAMAFCATSSVLF 386
Cdd:cd17471 293 ALQllnAIFIG---ITAGLGISYFQDLMPGQPGLATTLySNASR--IGSLLGGLL-AGVIAQYFGYRAVFLVCAVLALLA 366
|
..
gi 754492089 387 CL 388
Cdd:cd17471 367 LV 368
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
32-194 |
5.82e-04 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 41.49 E-value: 5.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 32 ALPVISAQFGVPAGSA---QMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLH 108
Cdd:cd17360 19 ALLYIKDDLGEVVLSTgwqELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 109 GLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAvlvwFSWHAIFWILALAALLASAMIFFFIDET 188
Cdd:cd17360 99 GLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGA----FSYLPGGWRWMLGLAAVPAVLQFIGLLF 174
|
....*.
gi 754492089 189 LPVERR 194
Cdd:cd17360 175 LPESPR 180
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
39-330 |
7.33e-04 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 41.44 E-value: 7.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 39 QFGVPAGSAQMTLSTYILGFALgQLLYGPMADSLG-----RKPV-ILGGTL-VFAAAAVACALAQSIDQLIIMRFLHGLA 111
Cdd:cd17484 27 DLHLGPASVQALTSIASLPWAI-KPLYGLLSDSVPifgyrRKPYlILAGALgALSWLALALVSNSSLALALLLLLLASLG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 112 AAAASVVINALMRDIYPKEEFSR---MMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAALLASAMIFFFIDET 188
Cdd:cd17484 106 VAFSDVVIDALVVEASRGAPQSLagdLQSLCWGSSAIGGIVGSYFSGYLLELLGPRTVFAVTSFFPLLLLIVAFFVKEER 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 189 LPVERRQKFHIRTTIGNFAslFRHKRVLSYMLASGFSFAGMFSFLSAGPFVYIELNHVSPQHFGYYFALNIVFLFVLTII 268
Cdd:cd17484 186 VPPHRTKENFDEQLKALWE--TVKQPSIWLPALFIFLYQATPSSGSAMFYFMTNELGFSPEFLGRLRVIGSIASLLGVLL 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754492089 269 NSRFVRRVGALNMFRAGLWIQFV--MAVWLVVS---AFLDVGFWALVIGVAAFVGCVSMISSNAMAV 330
Cdd:cd17484 264 YNRFLKHVPFRKIFFWTTVLLVLlgLTDLILVTrwnLKLGIPDHAFVLGDDAVVTVIGEILFMPILV 330
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
31-183 |
8.28e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 41.02 E-value: 8.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 31 PALPVISAQFGVPAGSAQ--MTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLH 108
Cdd:cd17315 18 GALLYIAKDLGFGLSTSLqgLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLL 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754492089 109 GLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFS--WHAIFWILALAALLASAMIFF 183
Cdd:cd17315 98 GLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPgwWRLMFALAAVPALLQLLLMFF 174
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
32-167 |
9.34e-04 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 9.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 32 ALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLV--FAAAAVACALAQSIDQLIIMRFLHG 109
Cdd:cd17380 21 AIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALwsLATLLTPLLAYSSLPLLILSRILLG 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 754492089 110 LAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIF 167
Cdd:cd17380 101 LGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVF 158
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
52-150 |
1.21e-03 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 40.70 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 52 STYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQ-SIDQLIIMRFLHGLAAAAASVVINALMRDIYPKE 130
Cdd:cd17356 52 SIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIgKWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKH 131
|
90 100
....*....|....*....|
gi 754492089 131 EFSRMMSFVMLVTTIAPLVA 150
Cdd:cd17356 132 IRGTLVSLYQLAITIGILVA 151
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
21-222 |
2.16e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.94 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 21 LMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILG-----FALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALA 95
Cdd:cd17391 7 FTGIGFSLIAPFLPLYIEQLGVTSGGLVELWSGLAFSstflvSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 96 QSIDQLIIMRFLHGLAAAAASVViNALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSWHAIFWILALAAL 175
Cdd:cd17391 87 TNVWQLLILRLLQGVFSGYVPNA-TALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLF 165
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 754492089 176 LASAMIFFFIDETLpvERRQKFHIRTTIGNFASLFRHKRVLSYMLAS 222
Cdd:cd17391 166 LAFLLTLFFVKEDF--KPVEKKKMVSTKEVWNSVPNPSLLISLFVTT 210
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
49-126 |
2.70e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.49 E-value: 2.70e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 754492089 49 MTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDI 126
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEI 106
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
6-163 |
3.17e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 39.57 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 6 HSSFK--IVFILGLLAMLMPLSIDMYLPALPVISAQFGVPAGSAQMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTL 83
Cdd:TIGR01299 161 HGRFQwaLFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLS 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 84 VFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFSW 163
Cdd:TIGR01299 241 VNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGW 320
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
49-388 |
3.18e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.56 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 49 MTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFA---AAAVACALAQSIDQLIIMRFLHGLAAAAASVVINALMRD 125
Cdd:pfam00083 50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVigaVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISE 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 126 IYPKEEFSRMMSFVMLVTTIAPLVAPMAGGAVLVWFS---WHAIFWILALAALLASAMIFF------------------- 183
Cdd:pfam00083 130 IAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNsdgWRIPLGLQLVPALLLIIGLLFlpesprwlvekgrleeare 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 184 --------------FIDETLPVERRQKFHIRTTIGNFASLFRHKRVL-SYMLASGFSFAGMFSFLSAGPFVYIELnhvsp 248
Cdd:pfam00083 210 vlaklrgvpdvdreLDEIKDSLEAGQEAEKASWKELFSTKTRRQRLLiGVMLQIFQQLTGINAIFYYSTTIFENL----- 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 249 qHFGYYFALNIVF---LFVLTIINSRFVRRVGALNMFRAGLWIQFVMAVWLVVSAFL-----DVGFWALVIGVAAFVGCV 320
Cdd:pfam00083 285 -GLSDSFLVTIIVgvvNFVFTFIAIFLVDRFGRRPLLLLGAAGMAICFVILGIVALLgvsksDWAGIVAIVFIALFIAFF 363
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 754492089 321 SMISSNAMAVILDEF--PHMAGTASSLAGTFRFGIGAIVGAL-LSMATFTTAWPMLWAMAFCATSSVLFCL 388
Cdd:pfam00083 364 AMGWGPVPWVIVSELfpLSVRSKAMALATAANWLANFLIGFLfPIITDAIGLGYTFFIFAGLLVLFIIFVF 434
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
64-306 |
3.24e-03 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 39.18 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 64 LYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHGLAAAAASVVInALMRDIYPKEEFSRMMSFVMLVT 143
Cdd:cd17389 83 ITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLST-AIVADVTSPKKRSKGMALIGVAF 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 144 TIAPLVAPMAGG--------AVLVWFSWHAIFWILALAALLAsaMIFFFIDETLPVERRqkfhiRTTIGNFASLFrhkrv 215
Cdd:cd17389 162 SLGFIIGPMIGAyfasftrsLGEVFFSMPALFALVLALADLL--FIFFFLPETLPSNLR-----RLGLVYFLYLF----- 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 216 lsymLASGFSFAgmFSFLSAGPFVYielnhVSPQHFGYYFALNIvflfVLTIINSRFVRRVGALNMFRAGLwiqfvMAVW 295
Cdd:cd17389 230 ----LFSGLEFT--LTFLTHQRFQY-----TSMQQGKMFFFIGI----IMALVQGGYVRRIKPGKEKKAVL-----QGLI 289
|
250
....*....|.
gi 754492089 296 LVVSAFLDVGF 306
Cdd:cd17389 290 LLIPAFLLIGW 300
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
32-169 |
7.48e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 38.40 E-value: 7.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 32 ALPVISAQFGVpaGSAQMTL--STYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACALAQSIDQLIIMRFLHG 109
Cdd:PRK11551 37 AAPRMAQEFGL--DVAQMGWafSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTG 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 754492089 110 LAAAAASVVINALMRDIYPKEEFSRMMSF----VMLVTTIAPLVAPMAGGAVlvwfSWHAIFWI 169
Cdd:PRK11551 115 VGLGGALPNLIALTSEAVGPRLRGTAVSLmycgVPFGGALASVIGVLAAGDA----AWRHIFYV 174
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
22-130 |
7.69e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.46 E-value: 7.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754492089 22 MPLSIDMYLPA----LPVISAQFGVPAGSA---QMTLSTYILGFALGQLLYGPMADSLGRKPVILGGTLVFAAAAVACAL 94
Cdd:TIGR00898 97 TEPCLDGWEYSydtfSSTIVTEWDLVCEDAwkvDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAF 176
|
90 100 110
....*....|....*....|....*....|....*.
gi 754492089 95 AQSIDQLIIMRFLHGLAAAAASVVINALMRDIYPKE 130
Cdd:TIGR00898 177 SPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKK 212
|
|
| |
