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Conserved domains on  [gi|753980235|ref|WP_041668001|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase [Streptomyces sp. PAMC 26508]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 11415180)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid; 1-acyl-sn-glycerol-3-phosphate acyltransferase, for example, converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position by utilizing either acyl-CoA or acyl-ACP as the fatty acyl donor;

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0008654|GO:0016746
PubMed:  18718904|18931347
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 46-275 3.91e-36

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


:

Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 128.20  E-value: 3.91e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235  46 VPAVLLLTPAHRDPLTRRWAYTVVRAFGVRIRVTGPavESARPEAGELVVANHVSWLDIPLVAAVLP--ARMVAKSEIRK 123
Cdd:COG0204    1 LRSLFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGL--ENLPADGPVLIVANHQSWLDILLLLAALPrpVRFVAKKELFK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235 124 WPLLGPFAALGGTLFIERDRLRALPGAVRTLAGALASGSRVAVFPQGSTWcGRGGGGRFRPAAFQAAIDAGAAVRPVRIS 203
Cdd:COG0204   79 IPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTRS-PDGRLLPFKTGAARLALEAGVPIVPVAID 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 753980235 204 YRTAgtntagaaafvgddplaaSLWRVVTAAGLTAEIRILPPVPAG--REPDRRGLARAAQSAVASDRANLPAS 275
Cdd:COG0204  158 GTER------------------ALPKGFLPRPGKVTVRIGPPIDPSdlEGEDRRELAERLRAAIEALLAELRAE 213
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 46-275 3.91e-36

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 128.20  E-value: 3.91e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235  46 VPAVLLLTPAHRDPLTRRWAYTVVRAFGVRIRVTGPavESARPEAGELVVANHVSWLDIPLVAAVLP--ARMVAKSEIRK 123
Cdd:COG0204    1 LRSLFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGL--ENLPADGPVLIVANHQSWLDILLLLAALPrpVRFVAKKELFK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235 124 WPLLGPFAALGGTLFIERDRLRALPGAVRTLAGALASGSRVAVFPQGSTWcGRGGGGRFRPAAFQAAIDAGAAVRPVRIS 203
Cdd:COG0204   79 IPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTRS-PDGRLLPFKTGAARLALEAGVPIVPVAID 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 753980235 204 YRTAgtntagaaafvgddplaaSLWRVVTAAGLTAEIRILPPVPAG--REPDRRGLARAAQSAVASDRANLPAS 275
Cdd:COG0204  158 GTER------------------ALPKGFLPRPGKVTVRIGPPIDPSdlEGEDRRELAERLRAAIEALLAELRAE 213
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 68-266 1.79e-31

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 115.06  E-value: 1.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235  68 VVRAFGVRIRVTGPavESARPEAGELVVANHVSWLDIPLVAAVLP--ARMVAKSEIRKWPLLGPFAALGGTLFIERDRLR 145
Cdd:cd07989    4 LLRLLGVRVRVEGL--ENLPPKGPVIIVANHQSYLDPLVLGAALPrpIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235 146 ALPGAVRTLAGALASGSRVAVFPQGSTWcGRGGGGRFRPAAFQAAIDAGAAVRPVRISYRTAGTNTAGAAAFVGddplaa 225
Cdd:cd07989   82 SAREALREAIEALKEGESVVIFPEGTRS-RDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPG------ 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 753980235 226 slwrvvtaaglTAEIRILPPVPAGREPDRRGLARAAQSAVA 266
Cdd:cd07989  155 -----------RVTVRIGEPIPPEGLELAEEDRKELREKVR 184
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 73-203 7.60e-23

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 90.87  E-value: 7.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235   73 GVRIRVTGPavESARPEAGELVVANHVSWLDIPLVAAVLPARM--VAKSEIRKWPLLGPFAALGGTLFIERDRLRALPGA 150
Cdd:TIGR00530   1 GLKVEVVGP--ENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIvfIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 753980235  151 VRTLAGALASGSRVAVFPQGsTWCGRGGGGRFRPAAFQAAIDAGAAVRPVRIS 203
Cdd:TIGR00530  79 LKAAIEVLKQGRSIGVFPEG-TRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 93-204 3.89e-22

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 88.57  E-value: 3.89e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235    93 LVVANHVSWLDIPLVAAVLPA-----RMVAKSEIRKWPLLGPFAALGGTLFIERDRLRALPGAVRTLAGALASGSRVAVF 167
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRklgrvRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGEWLLIF 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 753980235   168 PQGSTWCgRGGGGRFRPAAFQAAIDAGAAVRPVRISY 204
Cdd:smart00563  82 PEGTRSR-PGKLLPFKKGAARLALEAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 75-203 1.26e-20

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 85.02  E-value: 1.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235   75 RIRVTGPavESARPEAGELVVANHVSWLDIPLVAAVLPAR-----MVAKSEIRKWPLLGPFAALGGTLFIERDRLRALPG 149
Cdd:pfam01553   1 RIEVHGL--ENLPRGGPAIVVANHQSYLDVLLLSLALYKRgrplvFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 753980235  150 AVRTLAGALASGSRVAVFPQGSTWCgRGGGGRFRPAAFQAAIDAGAAVRPVRIS 203
Cdd:pfam01553  79 TLEYLVELLREGKLVVIFPEGTRSR-EGELLPFKKGAFRLAIEAGVPIVPVAIS 131
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 37-170 1.44e-08

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 55.32  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235   37 VVTLLGVLAVpavLLLTPahrDPLTRRWAYTVVRaFGVRIRVTGpaVESARPEAGELVVANHVSWLDIPLVAAVLP--AR 114
Cdd:PRK08633  397 LVTLIGTLYT---LLLLP---DSLLRFLLLLLMH-TRYRLRVEG--RENIPAKGGALLLGNHVSWIDWALLQAASPrpIR 467

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 753980235  115 MVAKSEIRKWPLLGPFAALGGTLFIERDRLRalpGAVRTLAGALASGSRVAVFPQG 170
Cdd:PRK08633  468 FVMERSIYEKWYLKWFFKLFGVIPISSGGSK---ESLEFIRKALDDGEVVCIFPEG 520
 
Name Accession Description Interval E-value
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 46-275 3.91e-36

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 128.20  E-value: 3.91e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235  46 VPAVLLLTPAHRDPLTRRWAYTVVRAFGVRIRVTGPavESARPEAGELVVANHVSWLDIPLVAAVLP--ARMVAKSEIRK 123
Cdd:COG0204    1 LRSLFLLLRRFRYRLVRLWARLLLRLLGVRVRVEGL--ENLPADGPVLIVANHQSWLDILLLLAALPrpVRFVAKKELFK 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235 124 WPLLGPFAALGGTLFIERDRLRALPGAVRTLAGALASGSRVAVFPQGSTWcGRGGGGRFRPAAFQAAIDAGAAVRPVRIS 203
Cdd:COG0204   79 IPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGESLVIFPEGTRS-PDGRLLPFKTGAARLALEAGVPIVPVAID 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 753980235 204 YRTAgtntagaaafvgddplaaSLWRVVTAAGLTAEIRILPPVPAG--REPDRRGLARAAQSAVASDRANLPAS 275
Cdd:COG0204  158 GTER------------------ALPKGFLPRPGKVTVRIGPPIDPSdlEGEDRRELAERLRAAIEALLAELRAE 213
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 68-266 1.79e-31

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 115.06  E-value: 1.79e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235  68 VVRAFGVRIRVTGPavESARPEAGELVVANHVSWLDIPLVAAVLP--ARMVAKSEIRKWPLLGPFAALGGTLFIERDRLR 145
Cdd:cd07989    4 LLRLLGVRVRVEGL--ENLPPKGPVIIVANHQSYLDPLVLGAALPrpIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGR 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235 146 ALPGAVRTLAGALASGSRVAVFPQGSTWcGRGGGGRFRPAAFQAAIDAGAAVRPVRISYRTAGTNTAGAAAFVGddplaa 225
Cdd:cd07989   82 SAREALREAIEALKEGESVVIFPEGTRS-RDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLPKGKKLPRPG------ 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 753980235 226 slwrvvtaaglTAEIRILPPVPAGREPDRRGLARAAQSAVA 266
Cdd:cd07989  155 -----------RVTVRIGEPIPPEGLELAEEDRKELREKVR 184
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 73-203 7.60e-23

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 90.87  E-value: 7.60e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235   73 GVRIRVTGPavESARPEAGELVVANHVSWLDIPLVAAVLPARM--VAKSEIRKWPLLGPFAALGGTLFIERDRLRALPGA 150
Cdd:TIGR00530   1 GLKVEVVGP--ENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIvfIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 753980235  151 VRTLAGALASGSRVAVFPQGsTWCGRGGGGRFRPAAFQAAIDAGAAVRPVRIS 203
Cdd:TIGR00530  79 LKAAIEVLKQGRSIGVFPEG-TRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 93-204 3.89e-22

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 88.57  E-value: 3.89e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235    93 LVVANHVSWLDIPLVAAVLPA-----RMVAKSEIRKWPLLGPFAALGGTLFIERDRLRALPGAVRTLAGALASGSRVAVF 167
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRklgrvRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARAALREAVELLKEGEWLLIF 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 753980235   168 PQGSTWCgRGGGGRFRPAAFQAAIDAGAAVRPVRISY 204
Cdd:smart00563  82 PEGTRSR-PGKLLPFKKGAARLALEAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 75-203 1.26e-20

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 85.02  E-value: 1.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235   75 RIRVTGPavESARPEAGELVVANHVSWLDIPLVAAVLPAR-----MVAKSEIRKWPLLGPFAALGGTLFIERDRLRALPG 149
Cdd:pfam01553   1 RIEVHGL--ENLPRGGPAIVVANHQSYLDVLLLSLALYKRgrplvFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 753980235  150 AVRTLAGALASGSRVAVFPQGSTWCgRGGGGRFRPAAFQAAIDAGAAVRPVRIS 203
Cdd:pfam01553  79 TLEYLVELLREGKLVVIFPEGTRSR-EGELLPFKKGAFRLAIEAGVPIVPVAIS 131
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 67-275 5.52e-14

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 69.17  E-value: 5.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235  67 TVVRAFG-VRIRVTGpavESARPEAGELVVANHVSWLDIPLVAAVLPARMVAKSEIRKWPLLGPFAALGGTLFIERDRLR 145
Cdd:cd07991    3 VLLFAFGfYVIKVHG---KPDPPEAPRIIVANHTSFIDPLILFSDLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235 146 ALPGAVRTLAGALASGSR--VAVFPQGSTWCgRGGGGRFRPAAFqaaiDAGAAVRPVRISYRTAGTNTAGaaafVGDDPL 223
Cdd:cd07991   80 DRKKVVEEIKERATDPNWppILIFPEGTTTN-GKALIMFKKGAF----EPGVPVQPVAIRYPNKFVDAFW----NSSGYS 150

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 753980235 224 AAS-LWRVVTAAGLTAEIRILPPV-PAGREPDRRGLARAAQSAVAsDRANLPAS 275
Cdd:cd07991  151 SLMyLFRLLTQPANVLEVEFLPVYtPSEEGEDPKEFANRVRLIMA-NKLGLPAT 203
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 72-142 2.57e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 55.71  E-value: 2.57e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 753980235  72 FGVRIRVTGPAVESARPEAgeLVVANHVSWLDIPLVAAVL-------PARMVAKSEIRKWPLLGPFAALGGTLFIERD 142
Cdd:cd07990    8 SGVKVVVYGDEPKLPKERA--LIISNHRSEVDWLVLWMLAdrfgrlgRLKIVLKDSLKYPPLGGWGWQLGEFIFLKRK 83
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 37-170 1.44e-08

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 55.32  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235   37 VVTLLGVLAVpavLLLTPahrDPLTRRWAYTVVRaFGVRIRVTGpaVESARPEAGELVVANHVSWLDIPLVAAVLP--AR 114
Cdd:PRK08633  397 LVTLIGTLYT---LLLLP---DSLLRFLLLLLMH-TRYRLRVEG--RENIPAKGGALLLGNHVSWIDWALLQAASPrpIR 467

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 753980235  115 MVAKSEIRKWPLLGPFAALGGTLFIERDRLRalpGAVRTLAGALASGSRVAVFPQG 170
Cdd:PRK08633  468 FVMERSIYEKWYLKWFFKLFGVIPISSGGSK---ESLEFIRKALDDGEVVCIFPEG 520
PRK06814 PRK06814
acyl-[ACP]--phospholipid O-acyltransferase;
37-170 1.82e-08

acyl-[ACP]--phospholipid O-acyltransferase;


Pssm-ID: 235865 [Multi-domain]  Cd Length: 1140  Bit Score: 55.36  E-value: 1.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235   37 VVTLLGVLAVPAVLLLTPAHrdpLTRRWAYTVVRAFgVRIRVTGpaVESArPEAGE--LVVANHVSWLDIPLVAAVLPAR 114
Cdd:PRK06814  406 FIALANLIVAILILRLLPTN---LLRDIFSILFRAF-YRVEVKG--LENL-QKAGKkaVIAANHVSFLDGPLLAAYLPEE 478

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 753980235  115 MV--AKSEIRKWPLLGPFAALGGTLFIERDRlralPGAVRTLAGALASGSRVAVFPQG 170
Cdd:PRK06814  479 PTfaIDTDIAKAWWVKPFLKLAKALPVDPTN----PMATRTLIKEVQKGEKLVIFPEG 532
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 68-205 2.81e-06

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 46.64  E-value: 2.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235  68 VVRAFGVRIRVTGPAVESARPEAGELVVANHVSWLDIPLVAAVLPAR-------MVAKSEIRKWPLLGPfaalGGTLFIE 140
Cdd:cd06551    4 LLLNFFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFLLLERGlrrdvygLMDEELLERYPFFTR----LGAFSVD 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 753980235 141 RDRLRALPGAVRTLAGALASGSRVA-VFPQGSTWCGRGGGGRFRPAAFQAAIDAGAAVRPVRISYR 205
Cdd:cd06551   80 RDSPRSAAKSLKYVARLLSKPGSVVwIFPEGTRTRRDKRPLQFKPGVAHLAEKAGVPIVPVALRYT 145
PRK08043 PRK08043
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
75-202 1.16e-05

bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;


Pssm-ID: 181207 [Multi-domain]  Cd Length: 718  Bit Score: 46.24  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235  75 RIRVTGpaVESARPEAGELVVANHVSWLDIPLVAAVLPARMV-------AKSEIRKWplLGPFAAlggtlFIERDRLRal 147
Cdd:PRK08043  15 RVRVTG--DTQALKGERVLITPNHVSFLDGILLALFLPVRPVfavytsiSQQWYMRW--LKPYID-----FVPLDPTK-- 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 753980235 148 PGAVRTLAGALASGSRVAVFPQGSTWCGRGGGGRFRPAAFQAAiDAGAAVRPVRI 202
Cdd:PRK08043  84 PMAIKHLVRLVEQGRPVVIFPEGRITVTGSLMKIYDGAGFVAA-KSGATVIPVRI 137
PLN02901 PLN02901
1-acyl-sn-glycerol-3-phosphate acyltransferase
 43-202 5.73e-05

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 215488 [Multi-domain]  Cd Length: 214  Bit Score: 43.18  E-value: 5.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235  43 VLAVPAVLLLTPAHRDPL---TRRWAyTVVRAFGVRIRVTG----PAvesarPEAGELVVANHVSWLDI-PLVAAVLPAR 114
Cdd:PLN02901   2 LVQHPFVLLFDRYRRKAQhfiNKVWA-TLSTSPFYKIEVEGlenlPS-----PDEPAVYVSNHQSFLDIyTLFHLGRPFK 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235 115 MVAKSEIRKWPLLGPFAALGGTLFIERDRLRALPGAVRTLAGALASGSRVAVFPQGsTWCGRGGGGRFRPAAFQAAIDAG 194
Cdd:PLN02901  76 FISKTSIFLIPIIGWAMYMTGHIPLKRMDRRSQLECLKRCMELLKKGASVFFFPEG-TRSKDGKLAAFKKGAFSVAAKTG 154


                 ....*...
gi 753980235 195 AAVRPVRI 202
Cdd:PLN02901 155 VPVVPITL 162
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 62-172 3.11e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 38.01  E-value: 3.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 753980235  62 RRWAYTVVRAFGVRIRVTGPavESARPEAGELVVANHV-SWLDIPLVAAVLPARM--VAKSEIRKWPLLGPFAALGGTLF 138
Cdd:cd07992    2 RLLSRVILRIYFRRITVVGR--ENVPKDGPVIFLGNHPnALIDPLLLAATLRRPVrfLAKADLFKNPLIGWLLESFGAIP 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 753980235 139 IERDRLRALPG--------AVRTLAGALASGSRVAVFPQGST 172
Cdd:cd07992   80 VYRPKDLARGGigkisnaaVFDAVGEALKAGGAIGIFPEGGS 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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