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Conserved domains on  [gi|752821256|ref|WP_041460441|]
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HNH endonuclease [Cronobacter sakazakii]

Protein Classification

HNH endonuclease( domain architecture ID 10003646)

HNH endonuclease contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA

Gene Ontology:  GO:0004519|GO:0003676|GO:0008270
PubMed:  28211904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
45-109 2.95e-20

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


:

Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 77.33  E-value: 2.95e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752821256  45 RGYGSKWDIIRARILKRDRHICQECLRNGRPvPATTVDHIKPKAHGGTDDDSNLRSLCWPCHKAK 109
Cdd:COG1403    1 RRPGREWPALRRAVLKRDNGRCQYCGRPFSG-DALEVDHIIPRSRGGTDTWENLVLLCRRCNRRK 64
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
45-109 2.95e-20

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 77.33  E-value: 2.95e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752821256  45 RGYGSKWDIIRARILKRDRHICQECLRNGRPvPATTVDHIKPKAHGGTDDDSNLRSLCWPCHKAK 109
Cdd:COG1403    1 RRPGREWPALRRAVLKRDNGRCQYCGRPFSG-DALEVDHIIPRSRGGTDTWENLVLLCRRCNRRK 64
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 66-112 3.34e-13

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 58.90  E-value: 3.34e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 752821256   66 CQECLRNGRPVPATTVDHIKPKAHGGTDDDSNLRSLCWPCHKAKTAK 112
Cdd:pfam01844   1 CQYCGRPFHISDALTVDHIIPLSDGGADDIENLILLCPSCHNKKHNR 47
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 52-110 5.88e-11

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 53.63  E-value: 5.88e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 752821256  52 DIIRARILKRDrHICQECLRNGrPVPATTVDHIKPKAHGGTDDDSNLRSLCWPCHKAKT 110
Cdd:cd00085    1 RSHRLVLLARD-GLCPYCGKPG-GTEGLEVDHIIPLSDGGNNDLDNLVLLCRKCHRKKH 57
guided_IscB NF040563
RNA-guided endonuclease IscB;
54-112 2.24e-09

RNA-guided endonuclease IscB;


Pssm-ID: 468538 [Multi-domain]  Cd Length: 315  Bit Score: 52.94  E-value: 2.24e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 752821256  54 IRARILKRDRHICQECLRNGRPVpatTVDHIKPKAHGGTDDDSNLRSLCWPCHKAKTAK 112
Cdd:NF040563 184 VREYLLERDGRTCQYCGAKDVPL---EVHHIVPRSKGGSDRVSNLILACEPCNQKKGNQ 239
HNHc smart00507
HNH nucleases;
54-106 8.69e-09

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 47.84  E-value: 8.69e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 752821256    54 IRARILKRDrHICQECLRngRPVPATTVDHIKPKAHGGTDDDSNLRSLCWPCH 106
Cdd:smart00507   2 LRRLLLHRD-GVCAYCGK--PASEGLEVDHIIPLSDGGNDDLDNLVLLCPKCH 51
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
45-109 2.95e-20

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 77.33  E-value: 2.95e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 752821256  45 RGYGSKWDIIRARILKRDRHICQECLRNGRPvPATTVDHIKPKAHGGTDDDSNLRSLCWPCHKAK 109
Cdd:COG1403    1 RRPGREWPALRRAVLKRDNGRCQYCGRPFSG-DALEVDHIIPRSRGGTDTWENLVLLCRRCNRRK 64
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 66-112 3.34e-13

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 58.90  E-value: 3.34e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 752821256   66 CQECLRNGRPVPATTVDHIKPKAHGGTDDDSNLRSLCWPCHKAKTAK 112
Cdd:pfam01844   1 CQYCGRPFHISDALTVDHIIPLSDGGADDIENLILLCPSCHNKKHNR 47
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 52-110 5.88e-11

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 53.63  E-value: 5.88e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 752821256  52 DIIRARILKRDrHICQECLRNGrPVPATTVDHIKPKAHGGTDDDSNLRSLCWPCHKAKT 110
Cdd:cd00085    1 RSHRLVLLARD-GLCPYCGKPG-GTEGLEVDHIIPLSDGGNNDLDNLVLLCRKCHRKKH 57
guided_IscB NF040563
RNA-guided endonuclease IscB;
54-112 2.24e-09

RNA-guided endonuclease IscB;


Pssm-ID: 468538 [Multi-domain]  Cd Length: 315  Bit Score: 52.94  E-value: 2.24e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 752821256  54 IRARILKRDRHICQECLRNGRPVpatTVDHIKPKAHGGTDDDSNLRSLCWPCHKAKTAK 112
Cdd:NF040563 184 VREYLLERDGRTCQYCGAKDVPL---EVHHIVPRSKGGSDRVSNLILACEPCNQKKGNQ 239
HNHc smart00507
HNH nucleases;
54-106 8.69e-09

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 47.84  E-value: 8.69e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 752821256    54 IRARILKRDrHICQECLRngRPVPATTVDHIKPKAHGGTDDDSNLRSLCWPCH 106
Cdd:smart00507   2 LRRLLLHRD-GVCAYCGK--PASEGLEVDHIIPLSDGGNDDLDNLVLLCPKCH 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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