|
Name |
Accession |
Description |
Interval |
E-value |
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
5-864 |
0e+00 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 1370.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 5 TTEEVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQEKRPYNKAVTSQKSLRAGGKHNDLENVGY 84
Cdd:COG0013 3 TSAEIRQKFLDFFESKGHTIVPSSSLVPKNDPTLLFTNAGMVQFKPYFLGQEKPPYPRATTSQKCVRTGGKHNDLENVGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 85 TARHHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDDEAASYWKKIAGFGDDRIIKIKTNDNFWS 164
Cdd:COG0013 83 TARHHTFFEMLGNFSFGDYFKEEAIAWAWELLTEVLGLPKERLWVTVYEDDDEAYDIWKKEIGVPEERIIRLGKKDNFWE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 165 MGDTGPCGPCSEIFYDHGEQIYGGLPGTKDEDGDRFIEIWNMVFMQYEQIDKDTSIELSQKSIDTGMGLERMTAVLQHVN 244
Cdd:COG0013 163 MGDTGPCGPCSEIFYDRGPEYGGGPPGSPGEDGDRYIEIWNLVFMQFNRDEDGTLTPLPKKNIDTGMGLERIAAVLQGVH 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 245 NNYNIDLFQEIINFTENIVKVK--VEGEAKFSYRVIADHLRASSFLIADGVIPSNEGRGYVLRRIMRRSMRHAHMLGAKE 322
Cdd:COG0013 243 SNYETDLFRPLIEAAAELTGVKygADEEDDVSLRVIADHIRAVAFLIADGVLPSNEGRGYVLRRILRRAVRHGRLLGIKE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 323 PLMYKLLPKLVDLMGNVYPELKRAERFISSILEQEEIRFKATLERGLKLLTEETEMLTK--GNELSGEVAFKLYDTYGFP 400
Cdd:COG0013 323 PFLYKLVPVVVEEMGDAYPELKEKQELIEKVLKAEEERFLRTLERGLKLLDEAIAKLKAagGKVLSGEDAFKLYDTYGFP 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 401 LDLTEDILKTRDISVDHKGFEEQMLMQKERARKSWLGSGESKTDQLWFDIKEQHGSTEFLGYTLNEAKCKIIALIKNNNL 480
Cdd:COG0013 403 LDLTEEIARERGLTVDEEGFEAAMEEQRERARAAAKFSGDAAVDGVWRELLEEGGPTEFVGYDTLEAEAKVLALVKDGEL 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 481 VNDIKEiDTQFLLISNQTPFYGESGGQIGDIGTIFAKDSEVEVIDTLKYLGSIIVHKCILKKGQINVGENANFSIDIRYR 560
Cdd:COG0013 483 VDSAKA-GEEVEVVLDRTPFYAESGGQVGDTGTIEGDGGVFEVTDTQKPPGGLIVHIGKVEEGELKVGDTVTAQVDAERR 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 561 QNLRIHHSATHILHAVLHEVLGKHVTQKGSLVAPTYLRFDISHSKAVTNEEITLIEDKVNEIIRDNHEVNTTFMATEDAV 640
Cdd:COG0013 562 RAIARNHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDFSHFEALTPEELAEIEDLVNEKIRENLPVETREMPLDEAK 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 641 KQGAMALFGEKYDSEVRVVKMGETSLELCAGTHVRRTGDIGCFKITSESAIAAGVRRIEAVCGEFVIKLMREKDSLLKSI 720
Cdd:COG0013 642 ALGAMALFGEKYGDEVRVVSIGDFSRELCGGTHVSRTGDIGLFKIVSESSVAAGVRRIEAVTGEAALEYLREQEALLKEL 721
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 721 ESSLKTNKNELITKVNNILERNKEVEKELEKTHLASLDLSIEQIEKQAAQITGIKLLYKKVGNIDNKILRQAAENLTKKV 800
Cdd:COG0013 722 AELLKAPPEELPERVEALLEELKELEKELEQLKAKLASAAADDLLAQAEEIGGVKVLAARVEGVDAKDLRDLADDLKDKL 801
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752757797 801 EDLIMVYIAEGIGKLSITVAVSKAITDK-YNA-DII---AKKlslflggsggggqaslAQAGGNDIGKL 864
Cdd:COG0013 802 GSGVVVLASVADGKVSLVAGVTKDLVKKgLKAgDLVkevAKIvggggg-----grpdmAQAGGKDPSKL 865
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
8-837 |
0e+00 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 899.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 8 EVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQEKRPYNKAVTSQKSLRAggkhNDLENVGYTAR 87
Cdd:TIGR00344 1 EIRQTFLDFFKEKGHQVIPSAPLVPRNDPTLLLTNAGMAQFKPIFTGIVKPPSNRLTNAQPCIRL----NDLENVGRTAR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 88 HHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDDEAASYWKKIaGFGDDRIIKIKTNDNFWSMGD 167
Cdd:TIGR00344 77 HHTLFEMLGNFSFGDYFKEEAIAFAWELLTEVLGLDKERLYVTVYEDDEEAYKIWEKI-GIPADRIIKCDAKDNFWDMGD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 168 tGPCGPCSEIFYDHgeqiYGGLPGTKDEDGDRFIEIWNMVFMQYEQIDKDTSIELSQKSIDTGMGLERMTAVLQHVNNNY 247
Cdd:TIGR00344 156 -GPCGPCTEIYYDF----VGGKPGEPLEENDRYLEVWNLVFMQFNRDPDGNYTPLPKKNIDTGMGLERFVAVLQGVPTNY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 248 NIDLFQEIINFTENIVKVK-----------VEGEAKFSYRVIADHLRASSFLIADGVIPSNEGRGYVLRRIMRRSMRHAH 316
Cdd:TIGR00344 231 DTDIFLPLIEKIEEITGVKydsnnagimdeKRVEDLRSLRVIADHTRAIAFMLADGVVPSNEGRGYVLRRLIRRALRHGK 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 317 MLGAKEPLMYKLLPKLVDLMGNVYPELKRAERFISSILEQEEIRFKATLERGLKLLtEETEMLTKGNELSGEVAFKLYDT 396
Cdd:TIGR00344 311 KLGLKEAFLYKLVPTLIEVLGDYYPELKEKQEFVEQILELEEERFAKTLERGLRLF-EKLLKKTGKKELDGEDAFKLYDT 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 397 YGFPLDLTEDILKTRDISVDHKGFEEQMLMQKERARKSwLGSGESKTDQLWFDIKeqhgsTEFLGYTLNEAKCKIIALIK 476
Cdd:TIGR00344 390 YGFPVELTKEIAEERGLTVDMPGFEALMAEQRERSKQN-SQFQEQEIALVNVYPA-----TEFLGYDDLEFEAKVIGLFD 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 477 NNNLVNDIKEIDTQFLlISNQTPFYGESGGQIGDIGTIFAKDSEVEVIDTLKYlGSIIVHKCILKKGQINVGENANFSID 556
Cdd:TIGR00344 464 DGYLVEQALAGQSVYV-ILDQTPFYAESGGQIGDTGYLIANDGKFRVVDVQKP-NGVVFHFGEVEGGSLKVGDKVIAVID 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 557 IRYRQNLRIHHSATHILHAVLHEVLGKHVTQKGSLVAPTYLRFDISHSKAVTNEEITLIEDKVNEIIRDNHEVNTTFMAT 636
Cdd:TIGR00344 542 EKRRFRIMRNHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREELEEIEDLANEQILANIPIKVIFMDL 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 637 EDAVKQGAMALFGEKY--DSEVRVVKMGETSLELCAGTHVRRTGDIGCFKITSESAIAAGVRRIEAVCGEFVIKLMREKD 714
Cdd:TIGR00344 622 DEAKRKGAFALFGEKYvpGEKVRVVSVGDFSVELCGGTHVRNTGEIGLFKIVKESGIAAGVRRIEAVTGEAAIEYLNEQE 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 715 SLLKSIESSLKTNKNELITKVNNILERNKEVEKELEKTHLASLDLSIEQIEKQAAQITGIKLLYKKVGNIDNKILRQAAE 794
Cdd:TIGR00344 702 DKLKELADILKVTPNELPKKVERFFEEWKALQKELESLKLKIADQKIDELKDKAETINGVKVLVEVVDAKDMKSLKTMAD 781
|
810 820 830 840
....*....|....*....|....*....|....*....|....
gi 752757797 795 NLTKKVEDLIMVYIAEGIGKLSITVAVSKA-ITDKYNADIIAKK 837
Cdd:TIGR00344 782 RLKSKLGSAIYVLASFAEGKVKLVCGVSNDvLTKKIKAGELINQ 825
|
|
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
5-828 |
0e+00 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 835.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 5 TTEEVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQ-----EKRPYNKAVTSQKSLRAGGKHNDL 79
Cdd:PLN02900 12 PGDRIRRTFLSFFESKGHTFLPSSPLVPVDDPTLLFTNAGMNQFKPIFLGTadpntPLRKLPRATNTQKCIRAGGKHNDL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 80 ENVGYTARHHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDD------EAASYWKKIagFGDDRI 153
Cdd:PLN02900 92 DDVGKDTYHHTFFEMLGNWSFGDYFKKEAIGWAWELLTKVYGLPADRLYATYFGGDEkqapddEARAIWLDY--LPEERV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 154 IKIKTNDNFWSMGDTGPCGPCSEIFYD-HGEQiygGLPGTKDEDGDRFIEIWNMVFMQYEQiDKDTSIE-LSQKSIDTGM 231
Cdd:PLN02900 170 LPFGCKDNFWEMGDTGPCGPCSEIHYDrIGER---DAADLVNNDDPRFIEIWNLVFIQFNR-EADGSLKpLPAKHVDTGM 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 232 GLERMTAVLQHVNNNYNIDLFQEIINFTENIVKV-----KVEGEA----KFSYRVIADHLRASSFLIADGVIPSNEGRGY 302
Cdd:PLN02900 246 GLERLASILQNKPSNYDTDLFMPIFDAIQEATGArpyagKVGAEDddrvDMAYRVVADHIRTLSFAIADGVVPSNEGRGY 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 303 VLRRIMRRSMRHAH-MLGAKEPLMYKLLPKLVDLMGNVYPELKRAERFISSILEQEEIRFKATLERGLKLLTEETEMLT- 380
Cdd:PLN02900 326 VLRRLLRRAVRYGRlLLGAEEGFFPALVEVVVELSGDVFPEVKKNEKRITEIIAEEELSFGKTLEKGIEKFKKALAAAKa 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 381 -KGNELSGEVAFKLYDTYGFPLDLTEDILKTRDISVDHKGFEEQMLMQKERARKSWLGSGE-------SKTDQLWfdIKE 452
Cdd:PLN02900 406 nGGPVLSGKDAFLLYDTYGFPVDLTELMAEERGVTVDMEGFEAAMEEARERSRAAHLKAGGgaielaaEATSWLQ--KQG 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 453 QHGSTEFLGY-TLNEAKCKIIALIKNNNLVNDIKEIDtQFLLISNQTPFYGESGGQIGDIGTI-FAKDSEVEVIDTLKYl 530
Cdd:PLN02900 484 VAATDDFLKYdWLSDHEAVVKAILTGGGFVESVSEGD-EVGIVLDKTSFYAESGGQIGDTGVLeGSGGAVVEVSDVQKA- 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 531 GSIIVHKCILKKGQINVGENANFSIDIRYRQNLRIHHSATHILHAVLHEVLGKHVTQKGSLVAPTYLRFDISHSKAVTNE 610
Cdd:PLN02900 562 GGFVLHIGTVTEGSVSVGDAVTCKVDYDRRRRIAPNHTATHLLNSALKEVLGDHVDQKGSLVAFEKLRFDFSHGKPMTPE 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 611 EITLIEDKVNEIIRDNHEVNTTFMATEDAvKQ--GAMALFGEKYDSEVRVVKMGET-SLELCAGTHVRRTGDIGCFKITS 687
Cdd:PLN02900 642 ELREVESLVNEWIGDALPVEAKEMPLADA-KRinGLRAVFGEKYPDPVRVVSVGGVySMELCGGTHVSNTAEAEAFKLLS 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 688 ESAIAAGVRRIEAVCGEFVIKLMREKDSLLKSIESSLKTN------------------------KNELITKVNNILERNK 743
Cdd:PLN02900 721 EEGIAKGIRRITAVTGGAAVEAINAADSLERELDSALKVEgsdlekkvaslksrvdaavipaakKEEIRARVSALQKELR 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 744 EVEKELEKthlASLDLSIEQIEKQAAQITGIKllyKKV------GNIDNKILRQAAENLTKKVEDL--IMVYIAEGIGKL 815
Cdd:PLN02900 801 AAQKEAAA---LRAKLAVAKATELASKALSAG---KSVlvarldVGVDAAALKEAAEKVIAKLGDPaaVVLSSDEEKGKV 874
|
890
....*....|...
gi 752757797 816 SITVAVSKAITDK 828
Cdd:PLN02900 875 SLVAAVPPGVVKK 887
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
8-559 |
0e+00 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 789.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 8 EVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQE-KRPYNKAVTSQKSLRAGgkhnDLENVGYTA 86
Cdd:pfam01411 1 EIRQTFLDFFEKKGHTRVPSSPVVPRNDPTLLFTNAGMNQFKPIFLGGVaKPPYNRATNSQKCIRAG----DLENVGRTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 87 RHHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDDEAASYWKKIAGFGDDRIIKIKTNDNFWSMG 166
Cdd:pfam01411 77 RHHTFFEMLGNFSFGDYFKEEAIEYAWELLTKELGLPPERLYVTVFEWDDEAGPIWEKIVGGPEERILRFGDKDNFWEMG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 167 DTGPCGPCSEIFYDHGEQIYGGLPGTKDE-DGDRFIEIWNMVFMQYEQIDKDTSIELSQKSIDTGMGLERMTAVLQHVNN 245
Cdd:pfam01411 157 DTGPCGPCSEIDYDRGEEIGGWDSGGTPTaDDDRFLEIWNLVFMQFNRENDGTLKPLPKKSIDTGMGLERLVAVLQDVRS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 246 NYNIDLFQEIINFTENIVKVKVE--GEAKFSYRVIADHLRASSFLIADGVIPSNEGRGYVLRRIMRRSMRHAHMLGAKEP 323
Cdd:pfam01411 237 NYDTDVFIPVIELIEEISGARYYtvDETDEAYRVIADHTRALTFALADGVVPSNEGRGYVLRRILRRAVRHAKKLGLKEP 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 324 LMYKLLPKLVDLMGNVYPELKRAERFISSILEQEEIRFKATLERGLKLLTEETEMLTKG-NELSGEVAFKLYDTYGFPLD 402
Cdd:pfam01411 317 FLYDLVPTVVEVLGDAYPELKEDEDFIQEILELEEERFAKTLERGLRLLERLIAKLKKGkKTLPGEDAFKLYDTYGFPVD 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 403 LTEDILKTRDISVDHKGFEEQMLMQKERARKSWLGSGEsktDQLWFDIKEQHGSTEFLGYTLNEAKCKIIALIKNNNLVN 482
Cdd:pfam01411 397 LTKEIAEERGLKVDMPGFEYAMVEQRERSKQAVKEKGE---KLDVSALKELPATTEFLGYDDLESEAKILALPKDGEFVA 473
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 752757797 483 DIKEIDTQFLLIsNQTPFYGESGGQIGDIGTIFAKDSEVEVIDTLKYlGSIIVHKCILKKGQINVGENANFSIDIRY 559
Cdd:pfam01411 474 EVLAGQEGGVIL-DRTPFYAESGGQIGDTGYIIGDGGEFRVTDVQKY-GGVVVHKGKLESGKLKVGDKVIAVIDEDR 548
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
6-243 |
1.76e-130 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 390.18 E-value: 1.76e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 6 TEEVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQEKRPYNKAVTSQKSLRAGGKHNdlenVGYT 85
Cdd:cd00673 1 ASEIRETFLSFFEKKGHTRVPSSPVVPRDDPTLLFTNAGMNQFKPIFLGEVPPPANRLVNSQKCIRAGDIDN----VGKT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 86 ARHHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDDEAASYWKKIAGFGDDRIIKIKTNDNFWSM 165
Cdd:cd00673 77 GRHHTFFEMLGNFSFGDYFKEEAIAFAWELLTEVLGLPKDRLYVSVFEGDDEEEAIWWWKIGLPGIRIERIGFKDNFWEM 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 752757797 166 GDTGPCGPCSEIFYDHGEQIYGGlpGTKDEDGDRFIEIWNMVFMQYEQIDKDTSIELSQKSIDTGMGLERMTAVLQHV 243
Cdd:cd00673 157 GGNGPCGPCSEIFYDRGEERDAA--SLPNEDDDRYLEIWNLVFMQYNRDADGTYRPLPKKIVDTGMGLERLVWVLQGV 232
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
656-698 |
2.29e-19 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 82.04 E-value: 2.29e-19
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 752757797 656 VRVVKMGETSLELCAGTHVRRTGDIGCFKITSESAIAAGVRRI 698
Cdd:smart00863 1 VRVVSIGDFSVELCGGTHVPNTGEIGAFKILSVSGAYWGLQRI 43
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AlaS |
COG0013 |
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA ... |
5-864 |
0e+00 |
|
Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Alanyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439784 [Multi-domain] Cd Length: 880 Bit Score: 1370.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 5 TTEEVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQEKRPYNKAVTSQKSLRAGGKHNDLENVGY 84
Cdd:COG0013 3 TSAEIRQKFLDFFESKGHTIVPSSSLVPKNDPTLLFTNAGMVQFKPYFLGQEKPPYPRATTSQKCVRTGGKHNDLENVGY 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 85 TARHHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDDEAASYWKKIAGFGDDRIIKIKTNDNFWS 164
Cdd:COG0013 83 TARHHTFFEMLGNFSFGDYFKEEAIAWAWELLTEVLGLPKERLWVTVYEDDDEAYDIWKKEIGVPEERIIRLGKKDNFWE 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 165 MGDTGPCGPCSEIFYDHGEQIYGGLPGTKDEDGDRFIEIWNMVFMQYEQIDKDTSIELSQKSIDTGMGLERMTAVLQHVN 244
Cdd:COG0013 163 MGDTGPCGPCSEIFYDRGPEYGGGPPGSPGEDGDRYIEIWNLVFMQFNRDEDGTLTPLPKKNIDTGMGLERIAAVLQGVH 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 245 NNYNIDLFQEIINFTENIVKVK--VEGEAKFSYRVIADHLRASSFLIADGVIPSNEGRGYVLRRIMRRSMRHAHMLGAKE 322
Cdd:COG0013 243 SNYETDLFRPLIEAAAELTGVKygADEEDDVSLRVIADHIRAVAFLIADGVLPSNEGRGYVLRRILRRAVRHGRLLGIKE 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 323 PLMYKLLPKLVDLMGNVYPELKRAERFISSILEQEEIRFKATLERGLKLLTEETEMLTK--GNELSGEVAFKLYDTYGFP 400
Cdd:COG0013 323 PFLYKLVPVVVEEMGDAYPELKEKQELIEKVLKAEEERFLRTLERGLKLLDEAIAKLKAagGKVLSGEDAFKLYDTYGFP 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 401 LDLTEDILKTRDISVDHKGFEEQMLMQKERARKSWLGSGESKTDQLWFDIKEQHGSTEFLGYTLNEAKCKIIALIKNNNL 480
Cdd:COG0013 403 LDLTEEIARERGLTVDEEGFEAAMEEQRERARAAAKFSGDAAVDGVWRELLEEGGPTEFVGYDTLEAEAKVLALVKDGEL 482
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 481 VNDIKEiDTQFLLISNQTPFYGESGGQIGDIGTIFAKDSEVEVIDTLKYLGSIIVHKCILKKGQINVGENANFSIDIRYR 560
Cdd:COG0013 483 VDSAKA-GEEVEVVLDRTPFYAESGGQVGDTGTIEGDGGVFEVTDTQKPPGGLIVHIGKVEEGELKVGDTVTAQVDAERR 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 561 QNLRIHHSATHILHAVLHEVLGKHVTQKGSLVAPTYLRFDISHSKAVTNEEITLIEDKVNEIIRDNHEVNTTFMATEDAV 640
Cdd:COG0013 562 RAIARNHSATHLLHAALREVLGEHVTQAGSLVAPDRLRFDFSHFEALTPEELAEIEDLVNEKIRENLPVETREMPLDEAK 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 641 KQGAMALFGEKYDSEVRVVKMGETSLELCAGTHVRRTGDIGCFKITSESAIAAGVRRIEAVCGEFVIKLMREKDSLLKSI 720
Cdd:COG0013 642 ALGAMALFGEKYGDEVRVVSIGDFSRELCGGTHVSRTGDIGLFKIVSESSVAAGVRRIEAVTGEAALEYLREQEALLKEL 721
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 721 ESSLKTNKNELITKVNNILERNKEVEKELEKTHLASLDLSIEQIEKQAAQITGIKLLYKKVGNIDNKILRQAAENLTKKV 800
Cdd:COG0013 722 AELLKAPPEELPERVEALLEELKELEKELEQLKAKLASAAADDLLAQAEEIGGVKVLAARVEGVDAKDLRDLADDLKDKL 801
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 752757797 801 EDLIMVYIAEGIGKLSITVAVSKAITDK-YNA-DII---AKKlslflggsggggqaslAQAGGNDIGKL 864
Cdd:COG0013 802 GSGVVVLASVADGKVSLVAGVTKDLVKKgLKAgDLVkevAKIvggggg-----grpdmAQAGGKDPSKL 865
|
|
| alaS |
TIGR00344 |
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the ... |
8-837 |
0e+00 |
|
alanine--tRNA ligase; The model describes alanine--tRNA ligase. This enzyme catalyzes the reaction (tRNAala + L-alanine + ATP = L-alanyl-tRNAala + pyrophosphate + AMP). [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273026 [Multi-domain] Cd Length: 845 Bit Score: 899.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 8 EVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQEKRPYNKAVTSQKSLRAggkhNDLENVGYTAR 87
Cdd:TIGR00344 1 EIRQTFLDFFKEKGHQVIPSAPLVPRNDPTLLLTNAGMAQFKPIFTGIVKPPSNRLTNAQPCIRL----NDLENVGRTAR 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 88 HHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDDEAASYWKKIaGFGDDRIIKIKTNDNFWSMGD 167
Cdd:TIGR00344 77 HHTLFEMLGNFSFGDYFKEEAIAFAWELLTEVLGLDKERLYVTVYEDDEEAYKIWEKI-GIPADRIIKCDAKDNFWDMGD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 168 tGPCGPCSEIFYDHgeqiYGGLPGTKDEDGDRFIEIWNMVFMQYEQIDKDTSIELSQKSIDTGMGLERMTAVLQHVNNNY 247
Cdd:TIGR00344 156 -GPCGPCTEIYYDF----VGGKPGEPLEENDRYLEVWNLVFMQFNRDPDGNYTPLPKKNIDTGMGLERFVAVLQGVPTNY 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 248 NIDLFQEIINFTENIVKVK-----------VEGEAKFSYRVIADHLRASSFLIADGVIPSNEGRGYVLRRIMRRSMRHAH 316
Cdd:TIGR00344 231 DTDIFLPLIEKIEEITGVKydsnnagimdeKRVEDLRSLRVIADHTRAIAFMLADGVVPSNEGRGYVLRRLIRRALRHGK 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 317 MLGAKEPLMYKLLPKLVDLMGNVYPELKRAERFISSILEQEEIRFKATLERGLKLLtEETEMLTKGNELSGEVAFKLYDT 396
Cdd:TIGR00344 311 KLGLKEAFLYKLVPTLIEVLGDYYPELKEKQEFVEQILELEEERFAKTLERGLRLF-EKLLKKTGKKELDGEDAFKLYDT 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 397 YGFPLDLTEDILKTRDISVDHKGFEEQMLMQKERARKSwLGSGESKTDQLWFDIKeqhgsTEFLGYTLNEAKCKIIALIK 476
Cdd:TIGR00344 390 YGFPVELTKEIAEERGLTVDMPGFEALMAEQRERSKQN-SQFQEQEIALVNVYPA-----TEFLGYDDLEFEAKVIGLFD 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 477 NNNLVNDIKEIDTQFLlISNQTPFYGESGGQIGDIGTIFAKDSEVEVIDTLKYlGSIIVHKCILKKGQINVGENANFSID 556
Cdd:TIGR00344 464 DGYLVEQALAGQSVYV-ILDQTPFYAESGGQIGDTGYLIANDGKFRVVDVQKP-NGVVFHFGEVEGGSLKVGDKVIAVID 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 557 IRYRQNLRIHHSATHILHAVLHEVLGKHVTQKGSLVAPTYLRFDISHSKAVTNEEITLIEDKVNEIIRDNHEVNTTFMAT 636
Cdd:TIGR00344 542 EKRRFRIMRNHSATHLLHAALQKVLGNHVWQAGSLVSFKKLRFDFSHFRALTREELEEIEDLANEQILANIPIKVIFMDL 621
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 637 EDAVKQGAMALFGEKY--DSEVRVVKMGETSLELCAGTHVRRTGDIGCFKITSESAIAAGVRRIEAVCGEFVIKLMREKD 714
Cdd:TIGR00344 622 DEAKRKGAFALFGEKYvpGEKVRVVSVGDFSVELCGGTHVRNTGEIGLFKIVKESGIAAGVRRIEAVTGEAAIEYLNEQE 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 715 SLLKSIESSLKTNKNELITKVNNILERNKEVEKELEKTHLASLDLSIEQIEKQAAQITGIKLLYKKVGNIDNKILRQAAE 794
Cdd:TIGR00344 702 DKLKELADILKVTPNELPKKVERFFEEWKALQKELESLKLKIADQKIDELKDKAETINGVKVLVEVVDAKDMKSLKTMAD 781
|
810 820 830 840
....*....|....*....|....*....|....*....|....
gi 752757797 795 NLTKKVEDLIMVYIAEGIGKLSITVAVSKA-ITDKYNADIIAKK 837
Cdd:TIGR00344 782 RLKSKLGSAIYVLASFAEGKVKLVCGVSNDvLTKKIKAGELINQ 825
|
|
| PLN02900 |
PLN02900 |
alanyl-tRNA synthetase |
5-828 |
0e+00 |
|
alanyl-tRNA synthetase
Pssm-ID: 215487 [Multi-domain] Cd Length: 936 Bit Score: 835.43 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 5 TTEEVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQ-----EKRPYNKAVTSQKSLRAGGKHNDL 79
Cdd:PLN02900 12 PGDRIRRTFLSFFESKGHTFLPSSPLVPVDDPTLLFTNAGMNQFKPIFLGTadpntPLRKLPRATNTQKCIRAGGKHNDL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 80 ENVGYTARHHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDD------EAASYWKKIagFGDDRI 153
Cdd:PLN02900 92 DDVGKDTYHHTFFEMLGNWSFGDYFKKEAIGWAWELLTKVYGLPADRLYATYFGGDEkqapddEARAIWLDY--LPEERV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 154 IKIKTNDNFWSMGDTGPCGPCSEIFYD-HGEQiygGLPGTKDEDGDRFIEIWNMVFMQYEQiDKDTSIE-LSQKSIDTGM 231
Cdd:PLN02900 170 LPFGCKDNFWEMGDTGPCGPCSEIHYDrIGER---DAADLVNNDDPRFIEIWNLVFIQFNR-EADGSLKpLPAKHVDTGM 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 232 GLERMTAVLQHVNNNYNIDLFQEIINFTENIVKV-----KVEGEA----KFSYRVIADHLRASSFLIADGVIPSNEGRGY 302
Cdd:PLN02900 246 GLERLASILQNKPSNYDTDLFMPIFDAIQEATGArpyagKVGAEDddrvDMAYRVVADHIRTLSFAIADGVVPSNEGRGY 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 303 VLRRIMRRSMRHAH-MLGAKEPLMYKLLPKLVDLMGNVYPELKRAERFISSILEQEEIRFKATLERGLKLLTEETEMLT- 380
Cdd:PLN02900 326 VLRRLLRRAVRYGRlLLGAEEGFFPALVEVVVELSGDVFPEVKKNEKRITEIIAEEELSFGKTLEKGIEKFKKALAAAKa 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 381 -KGNELSGEVAFKLYDTYGFPLDLTEDILKTRDISVDHKGFEEQMLMQKERARKSWLGSGE-------SKTDQLWfdIKE 452
Cdd:PLN02900 406 nGGPVLSGKDAFLLYDTYGFPVDLTELMAEERGVTVDMEGFEAAMEEARERSRAAHLKAGGgaielaaEATSWLQ--KQG 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 453 QHGSTEFLGY-TLNEAKCKIIALIKNNNLVNDIKEIDtQFLLISNQTPFYGESGGQIGDIGTI-FAKDSEVEVIDTLKYl 530
Cdd:PLN02900 484 VAATDDFLKYdWLSDHEAVVKAILTGGGFVESVSEGD-EVGIVLDKTSFYAESGGQIGDTGVLeGSGGAVVEVSDVQKA- 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 531 GSIIVHKCILKKGQINVGENANFSIDIRYRQNLRIHHSATHILHAVLHEVLGKHVTQKGSLVAPTYLRFDISHSKAVTNE 610
Cdd:PLN02900 562 GGFVLHIGTVTEGSVSVGDAVTCKVDYDRRRRIAPNHTATHLLNSALKEVLGDHVDQKGSLVAFEKLRFDFSHGKPMTPE 641
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 611 EITLIEDKVNEIIRDNHEVNTTFMATEDAvKQ--GAMALFGEKYDSEVRVVKMGET-SLELCAGTHVRRTGDIGCFKITS 687
Cdd:PLN02900 642 ELREVESLVNEWIGDALPVEAKEMPLADA-KRinGLRAVFGEKYPDPVRVVSVGGVySMELCGGTHVSNTAEAEAFKLLS 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 688 ESAIAAGVRRIEAVCGEFVIKLMREKDSLLKSIESSLKTN------------------------KNELITKVNNILERNK 743
Cdd:PLN02900 721 EEGIAKGIRRITAVTGGAAVEAINAADSLERELDSALKVEgsdlekkvaslksrvdaavipaakKEEIRARVSALQKELR 800
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 744 EVEKELEKthlASLDLSIEQIEKQAAQITGIKllyKKV------GNIDNKILRQAAENLTKKVEDL--IMVYIAEGIGKL 815
Cdd:PLN02900 801 AAQKEAAA---LRAKLAVAKATELASKALSAG---KSVlvarldVGVDAAALKEAAEKVIAKLGDPaaVVLSSDEEKGKV 874
|
890
....*....|...
gi 752757797 816 SITVAVSKAITDK 828
Cdd:PLN02900 875 SLVAAVPPGVVKK 887
|
|
| tRNA-synt_2c |
pfam01411 |
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be ... |
8-559 |
0e+00 |
|
tRNA synthetases class II (A); Other tRNA synthetase sub-families are too dissimilar to be included. This family includes only alanyl-tRNA synthetases.
Pssm-ID: 279719 [Multi-domain] Cd Length: 548 Bit Score: 789.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 8 EVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQE-KRPYNKAVTSQKSLRAGgkhnDLENVGYTA 86
Cdd:pfam01411 1 EIRQTFLDFFEKKGHTRVPSSPVVPRNDPTLLFTNAGMNQFKPIFLGGVaKPPYNRATNSQKCIRAG----DLENVGRTG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 87 RHHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDDEAASYWKKIAGFGDDRIIKIKTNDNFWSMG 166
Cdd:pfam01411 77 RHHTFFEMLGNFSFGDYFKEEAIEYAWELLTKELGLPPERLYVTVFEWDDEAGPIWEKIVGGPEERILRFGDKDNFWEMG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 167 DTGPCGPCSEIFYDHGEQIYGGLPGTKDE-DGDRFIEIWNMVFMQYEQIDKDTSIELSQKSIDTGMGLERMTAVLQHVNN 245
Cdd:pfam01411 157 DTGPCGPCSEIDYDRGEEIGGWDSGGTPTaDDDRFLEIWNLVFMQFNRENDGTLKPLPKKSIDTGMGLERLVAVLQDVRS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 246 NYNIDLFQEIINFTENIVKVKVE--GEAKFSYRVIADHLRASSFLIADGVIPSNEGRGYVLRRIMRRSMRHAHMLGAKEP 323
Cdd:pfam01411 237 NYDTDVFIPVIELIEEISGARYYtvDETDEAYRVIADHTRALTFALADGVVPSNEGRGYVLRRILRRAVRHAKKLGLKEP 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 324 LMYKLLPKLVDLMGNVYPELKRAERFISSILEQEEIRFKATLERGLKLLTEETEMLTKG-NELSGEVAFKLYDTYGFPLD 402
Cdd:pfam01411 317 FLYDLVPTVVEVLGDAYPELKEDEDFIQEILELEEERFAKTLERGLRLLERLIAKLKKGkKTLPGEDAFKLYDTYGFPVD 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 403 LTEDILKTRDISVDHKGFEEQMLMQKERARKSWLGSGEsktDQLWFDIKEQHGSTEFLGYTLNEAKCKIIALIKNNNLVN 482
Cdd:pfam01411 397 LTKEIAEERGLKVDMPGFEYAMVEQRERSKQAVKEKGE---KLDVSALKELPATTEFLGYDDLESEAKILALPKDGEFVA 473
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 752757797 483 DIKEIDTQFLLIsNQTPFYGESGGQIGDIGTIFAKDSEVEVIDTLKYlGSIIVHKCILKKGQINVGENANFSIDIRY 559
Cdd:pfam01411 474 EVLAGQEGGVIL-DRTPFYAESGGQIGDTGYIIGDGGEFRVTDVQKY-GGVVVHKGKLESGKLKVGDKVIAVIDEDR 548
|
|
| PRK01584 |
PRK01584 |
alanyl-tRNA synthetase; Provisional |
5-701 |
1.47e-147 |
|
alanyl-tRNA synthetase; Provisional
Pssm-ID: 234962 [Multi-domain] Cd Length: 594 Bit Score: 448.07 E-value: 1.47e-147
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 5 TTEEVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQEKRPYNKAVTSQKSLRAGgkhnDLENVGy 84
Cdd:PRK01584 2 TLDELRKKYIDFFKSKGHVEIAGKSLIPENDPTVLFTTAGMHPLVPYLLGEPHPSGTRLVDVQKCLRTG----DIDEVG- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 85 TARHHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFEL--PKDKLYATIYHTDD------EAASYWKKIaGFGDDRIIKI 156
Cdd:PRK01584 77 DLSHLTFFEMLGNWSLGAYFKEESIKYSFEFLTSPDYLniPKDKLYVTVFEGDEeiprdeETASVWESL-GIPKDRIFYL 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 157 KTNDNFWS-MGDTGPCGPCSEIFYDHGEQIYGGLPGTKDEDGdRFIEIWNMVFMQYEQIDKDTSIELSQKSIDTGMGLER 235
Cdd:PRK01584 156 SREHNWWGpVGETGPCGPDTEIFVDTGKPKCSVNCRPTCSCG-KYFEIWNNVFMQYNKDEDGNYEELKRKCVDTGMGIER 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 236 MTAVLQHVNNNYNIDLFQEIINFTENIVKvKVEGEAKF---SYRVIADHLRASSFLIAD--GVIPSNEGRGYVLRRIMRR 310
Cdd:PRK01584 235 TIAFLQGKSSVYDTEAFTPIIKRIEKISG-KIYGQNEEddrSIRIIADHIRAACFILGDpfVVLPSNVGQGYVLRRLIRR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 311 SMRHAHMLGAKEPLMYKLLPKLVDLMGNVYPELKRAERFISSILEQEEIRFKATLERGLKLLTEETEMLTKGNELSGEVA 390
Cdd:PRK01584 314 SIRHAKKLGIESHFLADLVDSVEEIYGSFYPELTEKKDFIKEELNKEEEKFFKTLRKGEQEFIKLIPNLGSSKIIPGDIA 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 391 FKLYDTYGFPLDLTEDILKTRDISVDHKGFEEQMLMQKERARKswlGSgesktdqlwfdikeqhgsteflgytlneakck 470
Cdd:PRK01584 394 FKLYDTYGFPYEITEELASEYGFTVDREGFDEHFKKHQKVSKK---GA-------------------------------- 438
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 471 iialiknnnlvndikeiDTQFllisnqtpfygeSGGqigdigtiFAKDSEveviDTLKYlgsiivhkcilkkgqinvgen 550
Cdd:PRK01584 439 -----------------DKVF------------KGG--------LADHSY----ETTKL--------------------- 456
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 551 anfsidiryrqnlrihHSATHILHAVLHEVLGKHVTQKGSLVAPTYLRFDISHSKAVTNEEITLIEDKVNEIIRDNHEVN 630
Cdd:PRK01584 457 ----------------HTATHLLHKALRLVLGDHVRQKGSNITAERLRFDFSHPEKMTDDEIKKVEDIVNLQIKNDLSVK 520
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 752757797 631 TTFMATEDAVKQGAMALFGEKYDSEVRVVKMGETSLELCAGTHVRRTGDIGCFKITSESAIAAGVRRIEAV 701
Cdd:PRK01584 521 KEVMSLEEAREKGAMALFGEKYEDIVKVYEIDGFSKEVCGGPHVENTGELGTFKIQKEQSSSSGVRRIRAI 591
|
|
| AlaRS_core |
cd00673 |
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is ... |
6-243 |
1.76e-130 |
|
Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. Class II assignment is based upon its predicted structure and the presence of three characteristic sequence motifs.
Pssm-ID: 238360 [Multi-domain] Cd Length: 232 Bit Score: 390.18 E-value: 1.76e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 6 TEEVRSKFITYFKANNHTHVPTSSLIPHNDPSLMFVNSGMVQFKNVFTGQEKRPYNKAVTSQKSLRAGGKHNdlenVGYT 85
Cdd:cd00673 1 ASEIRETFLSFFEKKGHTRVPSSPVVPRDDPTLLFTNAGMNQFKPIFLGEVPPPANRLVNSQKCIRAGDIDN----VGKT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 86 ARHHTFFEMLGNFSFGDYFKEQAIYYAWNLLTKEFELPKDKLYATIYHTDDEAASYWKKIAGFGDDRIIKIKTNDNFWSM 165
Cdd:cd00673 77 GRHHTFFEMLGNFSFGDYFKEEAIAFAWELLTEVLGLPKDRLYVSVFEGDDEEEAIWWWKIGLPGIRIERIGFKDNFWEM 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 752757797 166 GDTGPCGPCSEIFYDHGEQIYGGlpGTKDEDGDRFIEIWNMVFMQYEQIDKDTSIELSQKSIDTGMGLERMTAVLQHV 243
Cdd:cd00673 157 GGNGPCGPCSEIFYDRGEERDAA--SLPNEDDDRYLEIWNLVFMQYNRDADGTYRPLPKKIVDTGMGLERLVWVLQGV 232
|
|
| AlaX |
COG2872 |
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis] ... |
497-704 |
1.80e-33 |
|
Ser-tRNA(Ala) deacylase AlaX (editing enzyme) [Translation, ribosomal structure and biogenesis];
Pssm-ID: 442119 [Multi-domain] Cd Length: 238 Bit Score: 129.16 E-value: 1.80e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 497 QTPFYGESGGQIGDIGTIFAKDSEVEVIDTLKYlGSIIVHKcILKKGQINVGENANFSIDIRYRQNLRIHHSATHILHAV 576
Cdd:COG2872 32 RTAFYPTGGGQPGDTGTLVWDGKEIRVVDVRKE-DGEIVHV-LEGAPLPEVGDEVTGEIDWERRYRHMRLHTALHLLSAV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 577 LHEVLGKHVTqkGSLVAPTYLRFDISHSkAVTNEEITLIEDKVNEIIRDNHEVNTTFMATEDAVKQG----AMALFGEKY 652
Cdd:COG2872 110 VYREYGAPVT--GGQIGEDRARIDFDLP-EFDEEDLEEIEAEANELIAADLPVRIYWITREELEAIPglvrTMSVLPPPG 186
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 752757797 653 DSEVRVVKMGETSLELCAGTHVRRTGDIGCFKITSESAIAAGVRRIEAVCGE 704
Cdd:COG2872 187 VGRVRIVEIGGVDLQPCGGTHVANTGEIGRIKITKIEKKGKGNRRVYFTLGE 238
|
|
| tRNA_SAD |
smart00863 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of ... |
656-698 |
2.29e-19 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 197931 [Multi-domain] Cd Length: 43 Bit Score: 82.04 E-value: 2.29e-19
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 752757797 656 VRVVKMGETSLELCAGTHVRRTGDIGCFKITSESAIAAGVRRI 698
Cdd:smart00863 1 VRVVSIGDFSVELCGGTHVPNTGEIGAFKILSVSGAYWGLQRI 43
|
|
| tRNA_SAD |
pfam07973 |
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of ... |
656-698 |
2.87e-17 |
|
Threonyl and Alanyl tRNA synthetase second additional domain; The catalytically active from of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Pssm-ID: 429764 [Multi-domain] Cd Length: 43 Bit Score: 75.94 E-value: 2.87e-17
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 752757797 656 VRVVKMGETSLELCAGTHVRRTGDIGCFKITSESAIAAGVRRI 698
Cdd:pfam07973 1 VRVVSIGDFDVDLCGGTHVPNTGEIGAFKILKGESKNKGLRRI 43
|
|
| class_II_aaRS-like_core |
cd00768 |
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA ... |
11-236 |
3.63e-17 |
|
Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches the amino acid at the 2'-OH group, like class I aaRSs. These enzymes are usually homodimers. This domain is primarily responsible for ATP-dependent formation of the enzyme bound aminoacyl-adenylate. The substrate specificity of this reaction is further determined by additional domains. Intererestingly, this domain is also found is asparagine synthase A (AsnA), in the accessory subunit of mitochondrial polymerase gamma and in the bacterial ATP phosphoribosyltransferase regulatory subunit HisZ.
Pssm-ID: 238391 [Multi-domain] Cd Length: 211 Bit Score: 81.01 E-value: 3.63e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 11 SKFITYFKANNHT----HVPTSSLIPHNDPSL-------------MFVNSGMVQFKNVFTGQEKR--------PYNKAVT 65
Cdd:cd00768 1 IRSKIEQKLRRFMaelgFQEVETPIVEREPLLekaghepkdllpvGAENEEDLYLRPTLEPGLVRlfvshirkLPLRLAE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 66 SQKSLRAGGKHNDLenvgytaRHHTFFEMLGNFSFGDYF-----KEQAIYYAWNLLTKEFELpkdklyatiyhtddeaas 140
Cdd:cd00768 81 IGPAFRNEGGRRGL-------RRVREFTQLEGEVFGEDGeeaseFEELIELTEELLRALGIK------------------ 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 141 ywkkiagfgDDRIIKIKTNDNFWSmgdtGPCGPCSEIFYDHGEqiygglpgtkdedgDRFIEIWNMVFMQYEQIDKDTSI 220
Cdd:cd00768 136 ---------LDIVFVEKTPGEFSP----GGAGPGFEIEVDHPE--------------GRGLEIGSGGYRQDEQARAADLY 188
|
250 260
....*....|....*....|...
gi 752757797 221 ELSQK-------SIDTGMGLERM 236
Cdd:cd00768 189 FLDEAleyryppTIGFGLGLERL 211
|
|
| DHHA1 |
pfam02272 |
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called ... |
735-837 |
2.43e-09 |
|
DHHA1 domain; This domain is often found adjacent to the DHH domain pfam01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members. This domains is also found in alanyl tRNA synthetase, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.
Pssm-ID: 396724 [Multi-domain] Cd Length: 139 Bit Score: 56.30 E-value: 2.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 735 VNNILERNKEVEKELEKTHLASLDLSIEQIEKQAAQITGIKLLYKKVG-NIDNKILRQAAENLTKKVEDLIMVYIAEGIG 813
Cdd:pfam02272 1 LESLNEELKELEKELEELKEALALLKAKELLEKAEEINGVKVLVAEVGeGWDAGALGIAADRLKKKLGDPVIVLVAKEDG 80
|
90 100
....*....|....*....|....*
gi 752757797 814 -KLSITVAVSKAitDKYNADIIAKK 837
Cdd:pfam02272 81 dKVKVSARSSKD--KGVDAGELLKE 103
|
|
| PLN02961 |
PLN02961 |
alanine-tRNA ligase |
493-686 |
2.64e-08 |
|
alanine-tRNA ligase
Pssm-ID: 178546 [Multi-domain] Cd Length: 223 Bit Score: 55.47 E-value: 2.64e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 493 LISNQTPFYGESGGQIGDIGTI--FAKDSEVEVIDTLKYLGsIIVH------KCILKKGQINVGENANFSIDI-RYRQNL 563
Cdd:PLN02961 5 LVLDRTIFHPQGGGQPSDTGRIviSGGDTKFSVQDVRRKDG-VVYHygvfegSNPESASPFEAGDEVTVTVDEsRRKLHS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 564 RIHhSATHILHAVL--------------HEVLGKHVTQKGSLvaptylrfDISHSKAVTNEeitlIEDKVNEIIRDNHEV 629
Cdd:PLN02961 84 RLH-SAGHLLDVCMarvglgplepgkgyHFPDGPFVEYKGKI--------PQGELDSKQDE----LEAEANELIAEGGKV 150
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 752757797 630 NTTFMATEDAVK--QGAMALFGEKyDSEVRVVKMGETSLELCAGTHVRRTGDIGCFKIT 686
Cdd:PLN02961 151 SAAVLPYDEAAElcGGSLPDYIAK-DSTPRIVKIGDSPGCPCGGTHVADVSEITSVKVT 208
|
|
| ThrS |
COG0441 |
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA ... |
565-687 |
2.43e-06 |
|
Threonyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Threonyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440210 [Multi-domain] Cd Length: 639 Bit Score: 51.19 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 565 IHHSATHIL-HAVLHEVLGKHVTqkgslVAPT-----YLRFDISHSkaVTNEEITLIEDKVNEIIRDNHEVNTTFMATED 638
Cdd:COG0441 71 LRHSAAHLLaQAVKRLYPDAKLT-----IGPViengfYYDFDLERP--FTPEDLEKIEKEMKEIIKEDLPIEREEVSREE 143
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 752757797 639 AVKqgamaLF---GEKY----------DSEVRVVKMGETsLELCAGTHVRRTGDIGCFKITS 687
Cdd:COG0441 144 AIE-----LFkekGEPYkveliedipeDEEISLYRQGEF-VDLCRGPHVPSTGKIKAFKLLS 199
|
|
| PRK12444 |
PRK12444 |
threonyl-tRNA synthetase; Reviewed |
567-689 |
1.42e-03 |
|
threonyl-tRNA synthetase; Reviewed
Pssm-ID: 183530 [Multi-domain] Cd Length: 639 Bit Score: 42.43 E-value: 1.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 567 HSATHIL-HAVlhevlgKHVTQKGSL-VAPT-----YLRFDISHSkaVTNEEITLIEDKVNEIIRDNHEVNTTFMATEDA 639
Cdd:PRK12444 77 HSAAHILaQAV------KRLYGDVNLgVGPViengfYYDMDLPSS--VNVEDLRKIEKEMKKIINENIKIERVEVSREEA 148
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 752757797 640 VKqgamaLFGEKYDS-------------EVRVVKMGETsLELCAGTHVRRTGDIGCFKITSES 689
Cdd:PRK12444 149 AK-----LFQEMNDRlklelleaipsgeSITLYKQGEF-VDLCRGPHLPSTGYLKAFQLTHVS 205
|
|
| PLN02837 |
PLN02837 |
threonine-tRNA ligase |
563-693 |
2.14e-03 |
|
threonine-tRNA ligase
Pssm-ID: 215450 [Multi-domain] Cd Length: 614 Bit Score: 41.81 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 752757797 563 LRIHHSATHILHAVLHEVLGKHVTQKGSLVAPT-YLRFDIshsKAVTNEEITLIEDKVNEIIRDNHEVNTTFMATEDAVK 641
Cdd:PLN02837 44 LKIRHTCAHVMAMAVQKLFPDAKVTIGPWIENGfYYDFDM---EPLTDKDLKRIKKEMDRIISRNLPLVREEVSREEAQK 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 752757797 642 QgAMALfGEKYDSEV---------RVVKMGETSLELCAGTHVRRTGDIGCFKITSESAIAA 693
Cdd:PLN02837 121 R-IMAI-NEPYKLEIlegikeepiTIYHIGEEWWDLCAGPHVERTGKINKKAVELESVAGA 179
|
|
| |
