|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
25-462 |
1.17e-79 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 252.11 E-value: 1.17e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 25 VMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGF 104
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 105 ATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVT 184
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 185 LIGVFMAwrflplpvsrpapyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfvirerrarhPL 264
Cdd:cd17503 161 ILALLLA-----------------------------------------------------------------------PL 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 265 VNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIF 344
Cdd:cd17503 170 LDLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLA 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 345 GIVLFAMSAMLFAVSDIELAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFGVNIVALT 424
Cdd:cd17503 250 GLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATL 329
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 750170587 425 IEFGDHSGGI-------------PTIGAFHTAWWLVAVFVAMAAIPVWKMR 462
Cdd:cd17503 330 LTNRTQFHHSrlsellaqqvqkqALIIAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
26-421 |
2.26e-79 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 254.61 E-value: 2.26e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 26 MLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFA 105
Cdd:TIGR00711 8 MLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 106 TSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTL 185
Cdd:TIGR00711 88 PNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 186 IGVFMAWRFLPLPVsRPAPYRFDFPGLVLLGIAIGLSLDTLNRLQE---LAGQEVriAIGGAVAAIALVLFVIRERRARH 262
Cdd:TIGR00711 168 IVVVVAFFILPRDK-PAASENFDFLGLLLLSVGLGSLLYGLSEGPErgwFDSNEI--LILSITGLVAIIAFVVWELTDDN 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 263 PLVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLV 342
Cdd:TIGR00711 245 PLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLV 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 343 IFGIVLFAMSAMLFAVS-DIELAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFGVNIV 421
Cdd:TIGR00711 325 TIGLILYAVGFYWRAFTfTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALI 404
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
25-459 |
4.85e-51 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 176.98 E-value: 4.85e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 25 VMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGF 104
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 105 ATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVT 184
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 185 LIGVFMAwrflplpvsrpapyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfvirerrarhpl 264
Cdd:cd17321 161 LVALLLA------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 265 vnigllrnPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIF 344
Cdd:cd17321 168 --------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 345 GIVLFAMSAMLFAVSDIELAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFGVNIVALT 424
Cdd:cd17321 240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 750170587 425 I-------------EFGDHSGGIPTIGAFHTAWWLVAVFVAMAAIPVW 459
Cdd:cd17321 320 LtaglsanlgdsgvAALLSAAAAAFAAGFHLAFLVAAALALLAALLAL 367
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-415 |
9.15e-40 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 146.27 E-value: 9.15e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 16 RWRWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLF 95
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 96 TVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRY 175
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 176 VMFAPVPVTLIGVFMAWRFLPLPVsrpapyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfvi 255
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESR-------------------------------------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 256 RERRARHPLVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADR 335
Cdd:COG2814 190 PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 336 LSARKLVIFGIVLFAMSAMLFAVSDielAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGA 415
Cdd:COG2814 270 FGRRRLLLIGLLLLALGLLLLALAG---SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
25-456 |
5.58e-33 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 127.29 E-value: 5.58e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 25 VMLGTMATVLSATVVNVALHDIMLEFGiRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGF 104
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 105 ATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPvt 184
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLP-- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 185 lIGVFMawrflplpvsrpapyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfvirerrarhpl 264
Cdd:cd17502 158 -IGGLA-------------------------------------------------------------------------- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 265 vnIGLLRNPAFvyANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRL-SARKLVI 343
Cdd:cd17502 163 --LALLRTILL--SSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTgRYKPLIV 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 344 FGIVLFAMSAMLFAVSDIELAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFGVnival 423
Cdd:cd17502 239 IGTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGV----- 313
|
410 420 430
....*....|....*....|....*....|...
gi 750170587 424 tiefgdhsggiptigAFHTAWWLVAVFVAMAAI 456
Cdd:cd17502 314 ---------------AITDVFLVALALAALAFL 331
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
20-462 |
2.38e-32 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 126.54 E-value: 2.38e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 20 LAVATVMLGTMATVLSAtvvnvALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVIS 99
Cdd:cd17504 1 LALAALAVMLVETMLSP-----ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 100 LLGGFATSPEQLIAARIGQGAMAGLMqPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFA 179
Cdd:cd17504 76 LLAAFAPNLPVLIAGRALQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 180 PVPVTLIGVFMAwrflplpvsrpapyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfvirerr 259
Cdd:cd17504 155 AAPVAVLLAALV-------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 260 arhPLVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQ----TALEFTATEAGLLMLPAGIVLGMTFPLAGRLADR 335
Cdd:cd17504 167 ---PLIDLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIAR 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 336 LSARKLVIFGIVLFAMSAMLFAVSDIELAfgWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGA 415
Cdd:cd17504 244 VGPRRVLLIGLVISAVGLLLLALLHSSLW--ALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSA 321
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 750170587 416 FGVNIVALTI---EFGDHSGGIPTIGAFHTAWWLVAVFVAMAAIPVWKMR 462
Cdd:cd17504 322 IGPAIAGAILttyTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
16-460 |
1.91e-31 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 125.61 E-value: 1.91e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 16 RWRWLAVAtvmLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLF 95
Cdd:PRK10504 9 RWQLWIVA---FGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 96 TVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRY 175
Cdd:PRK10504 86 TLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 176 VMFAPVPVTLIGVFMAWRFLPLPVSRPApyRFDFPGLVLLGIAIGLSLDTLNRLQELAGQEVRIAIGGAVAAIALVLFVI 255
Cdd:PRK10504 166 IFLINIPVGIIGAIATLMLMPNYTMQTR--RFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 256 RERRARHPLVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGI-VLGMTfPLAGRLAD 334
Cdd:PRK10504 244 HARNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLgSMGMK-RIVVQVVN 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 335 RLSARKLVIFGIVLFAMSAMLFAVSDIelaFGW-LALWTVLGRIGI--GFMLPALSTGALNPLAPEQLGAGSSTINFTRQ 411
Cdd:PRK10504 323 RFGYRRVLVATTLGLALVSLLFMLVAL---LGWyYLLPFVLFLQGMvnSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQ 399
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 750170587 412 LGGAFGVNIVALTIEFGDHSGGIPTIGAFHTA----WWLVAVFVAMAAIPVWK 460
Cdd:PRK10504 400 LSMSIGVTIAGLLLGLFGQQHVSVDSGATHTVfmytYLCMALIIALPALIFAR 452
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
25-417 |
5.06e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 114.05 E-value: 5.06e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 25 VMLGTMATVLSATVVNVALH-DIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGG 103
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 104 FATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPV 183
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 184 TLIGVFMAWRFLPLPVSRPapyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlFVIRERRARHP 263
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKR--------------------------------------------------PKPAEEARLSL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 264 LVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTaLEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVI 343
Cdd:pfam07690 191 IVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 750170587 344 FGIVLFAMSAMLFAVSDIELAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFG 417
Cdd:pfam07690 270 LALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
27-462 |
4.87e-27 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 111.51 E-value: 4.87e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 27 LGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFAT 106
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 107 SPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLI 186
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 187 GVFMAWRFLPLPVSRPAPyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfviRERRARHPLVN 266
Cdd:cd17325 163 ALVLALLLLPEPRPPPNK---------------------------------------------------RAVSAARLRSG 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 267 IGLLRNPAFVYANLGAMALGLALFGSTY-LVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIFG 345
Cdd:cd17325 192 LRLLLRDRRLLALFLAIFVLAFAFGALEpFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 346 IVLFAMSAMLFAVSDielAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFGVNIvalti 425
Cdd:cd17325 272 LLLSAVALLLLPLAT---SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLL----- 343
|
410 420 430
....*....|....*....|....*....|....*..
gi 750170587 426 efgdhSGGIPTIGAFHTAWWLVAVFVAMAAIPVWKMR 462
Cdd:cd17325 344 -----GGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-462 |
1.10e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 107.65 E-value: 1.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 16 RWRWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLF 95
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 96 TVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRY 175
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 176 VMFAPVPVTLIGVFMawrflplpvsrpapyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfvi 255
Cdd:COG2271 166 AFLILGLPGLLLALL----------------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 256 rerrarhplvnigllrnpAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADR 335
Cdd:COG2271 181 ------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 336 LSARKLVIFGIVLFAMSAMLFAVSDIELAFGWLALWTVLGrIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGA 415
Cdd:COG2271 243 LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAG-FGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 750170587 416 FGVNIValtiefgdhsGGIPTIGAFHTAWWLVAVFVAMAAIPVWKMR 462
Cdd:COG2271 322 LGPLLV----------GYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-459 |
3.40e-24 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 103.42 E-value: 3.40e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 18 RWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTV 97
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 98 ISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVM 177
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 178 FAPVPVTLIGVFMAWRFLPLpvsrpapyrfdfpglvLLGIAiglsldtlnrlqelagqevriaiggavaaialvlfvire 257
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLRQ----------------VWGLA--------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 258 rrarhplvnigllrnpafvyanLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLS 337
Cdd:cd17319 186 ----------------------LGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 338 --ARKLVIFGIVLFAMSAMLFAVSDIELAfgWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGA 415
Cdd:cd17319 244 rgARRLVIIIGLLLAAVGLLLAYLTTSPV--VAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGF 321
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 750170587 416 FGVNIVALTIEfgdhsggipTIGAFHTAWWLVAVFVAMAAIPVW 459
Cdd:cd17319 322 VAPLLIGYLVD---------ATGSYTAAFLFLAAVALLAALLVL 356
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
16-300 |
1.08e-23 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 100.66 E-value: 1.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 16 RWRWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLF 95
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 96 TVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRY 175
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 176 VMFAPVPVTLIGVFMAWRFLPLPVSRPAPYRFDFPGLVLLGIAIGLSLDTLNRLQELAGQEVRIAIGGAVAAIALVLFVI 255
Cdd:COG0477 170 IFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 750170587 256 RERRARHPLVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFV 300
Cdd:COG0477 250 LLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
22-417 |
1.33e-23 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 101.88 E-value: 1.33e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 22 VATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLL 101
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 102 GGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDqWDWRYVMFAPV 181
Cdd:cd17474 81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 182 PVTLIGvFMAWRFLPLPVSRPAPyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfvirERRAR 261
Cdd:cd17474 160 ALIPVA-FLAILFLLPEPKEKAK----------------------------------------------------SSSAT 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 262 HPLVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGR-LADRLSARK 340
Cdd:cd17474 187 KLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRlLKKRFGARR 266
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 750170587 341 LVIFGIVLFAMSAMLFAVSDielAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFG 417
Cdd:cd17474 267 ILVIGLLLYALSLLLLGFVP---SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
26-417 |
2.25e-22 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 98.01 E-value: 2.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 26 MLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFA 105
Cdd:cd17324 5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 106 TSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTL 185
Cdd:cd17324 85 PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 186 IGVFMAWRFLPLPVSRPAPYRFDFPGLVLlgiaiglsldtlnrlqelagqevriaiggavaaialvlfvirerrarhplv 265
Cdd:cd17324 165 LAALLLWRLLPSLPPKKPGSLGLLSSLLL--------------------------------------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 266 nigLLRNPAFVYANLGAMALGLALFGS-TYLVPLFVQTALEFTATEAGLLMLpAGIVLGMTFPLAGRLADRLSARKLVIF 344
Cdd:cd17324 194 ---LLRNPRLRLAYLITFLLFGGFFALyTYLAPFLTDVPGFSSSAIIGLLLL-FGVAGVVGSPLAGRLADRGGRRALLIA 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 750170587 345 GIVL-FAMSAMLFAVSDIELAFGWLALWTVLgrigiGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFG 417
Cdd:cd17324 270 LLLLaAALLLLTLLGPSPLLLLVGLVLWGLG-----FFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALG 338
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
19-423 |
4.01e-22 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 97.65 E-value: 4.01e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 19 WLAVATVMLGTMATvlsaTVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVI 98
Cdd:cd17320 2 LLLALLVALGPLAI----DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 99 SLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMF 178
Cdd:cd17320 78 SLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 179 APVPVTLIGVFMAWRFlpLPVSRPAPYRFDFPGLVLLGIAIglsldtlnrlqelagqevriaiggavaaialvlfvirer 258
Cdd:cd17320 158 FLALLGLLLLLLVLLF--LPETLPEEKRKPLLSSLLRAYKR--------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 259 rarhplvnigLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSA 338
Cdd:cd17320 197 ----------VLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGP 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 339 RKLVIFGIVLFAMSAMLFAVSDIELAFGWLALWTVLG--RIGIGFMLPALSTGALNPLaPEQLGAGSSTINFTRQLGGAF 416
Cdd:cd17320 267 RRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFliFFGFGLIFPNATSLALEPF-PHVAGTASALLGFLQFLIGAL 345
|
....*..
gi 750170587 417 GVNIVAL 423
Cdd:cd17320 346 AGALVGL 352
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-463 |
4.63e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 97.64 E-value: 4.63e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 18 RWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTV 97
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 98 ISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVM 177
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 178 FAPVPVTLIGVFMAWRFLP-LPVSRPAPYRFDFPGLvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfvir 256
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRdPPAGAAAAAKASLRDQ-------------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 257 errarhplvnIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRL 336
Cdd:COG2223 199 ----------LEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 337 SARKLVIFGIVLFAMSAMLFAVSDIELAFGWLALWTVLGRIGIGFMLPALSTGALNPlaPEQLGAGSSTINFTRQLGGAF 416
Cdd:COG2223 269 GGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP--TKNAGAVYGLVGAAGGLGGFL 346
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 750170587 417 GVNIVALTIEfgdhsggipTIGAFHTAWWLVAVFVAMAAIPVWKMRV 463
Cdd:COG2223 347 GPLLFGALLD---------ATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
18-423 |
9.78e-22 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 97.49 E-value: 9.78e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 18 RWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTV 97
Cdd:PRK14995 4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 98 ISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNR-RGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYV 176
Cdd:PRK14995 84 ASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKqRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 177 MFAPVPVTLIGVFMAWRFLPLPVSRPAPyRFDFPGLVLLGIAIGLSLDTLNRLQELAGQEVRIAIGGAVAAIALVLFVIR 256
Cdd:PRK14995 164 FLINVPIVLVVMGLTARYVPRQAGRRDQ-PLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 257 ERRARHPLVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRL 336
Cdd:PRK14995 243 QLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 337 SARKLVIFGIVLFAMS----AMLFAVSDIELAFGWLALwtvlgrigIGFMLPA---LSTGALNPLAPEQLGAGSSTI-NF 408
Cdd:PRK14995 323 GLRLVATGGMALSALSfyglAMTDFSTQQWQAWGLMAL--------LGFSAASallASTSAIMAAAPPEKAAAAGAIeTM 394
|
410
....*....|....*
gi 750170587 409 TRQLGGAFGVNIVAL 423
Cdd:PRK14995 395 AYELGAGLGIAIFGL 409
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
23-459 |
5.27e-18 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 85.01 E-value: 5.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 23 ATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLG 102
Cdd:cd17476 1 ATISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 103 GFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIF-PRNRRGQAMGIYGMGVILAPALGPVLGGFLVD--QWDWRYVMFA 179
Cdd:cd17476 81 GFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQlaWWPWIFWFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 180 pvpvtlIGVFMawrflplpvsrpapyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvLFVirerr 259
Cdd:cd17476 161 ------ILAAI-------------------------------------------------------------VAV----- 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 260 arhplvnIGLLRNPAFVYANLGAMALGLALFGS-TYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSA 338
Cdd:cd17476 169 -------AAIFWTSPSFIAVLLAVFLGWASFGIwVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPP 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 339 RKLVIFGIVLFAMSAMLFAVSDIELAFGWLALWTV-LGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFG 417
Cdd:cd17476 242 SYIMAISMVAFLVGPILFATMPVHQTYWAQAFPAMiVAPFGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIG 321
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 750170587 418 VNIVAlTIEFGDHSGGIPTIGAFHTAWWLVAVFVAMAAIPVW 459
Cdd:cd17476 322 LGIAG-TVETSVNEDGADLLKGYRAAWYLGIGLAALGLLISV 362
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
25-456 |
1.56e-15 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 77.85 E-value: 1.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 25 VMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGF 104
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 105 ATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQ--WDWRYVMFAPVP 182
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 183 VTLIGVFMAWRFLPLPVSRPAPYRFDFPGLVLLGIAiglsldtlnrlqelagqevriaiggavaaialvlfvirerrarh 262
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 263 plvnIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLV 342
Cdd:cd06174 197 ----KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 343 IfgIVLFAMSAMLFAVSDIELAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFGVNIVA 422
Cdd:cd06174 273 L--LIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAG 350
|
410 420 430
....*....|....*....|....*....|....
gi 750170587 423 LTiefgdhsggIPTIGAFHTAWWLVAVFVAMAAI 456
Cdd:cd06174 351 FL---------LAATFGLTGAFLVLAVLLLLAAI 375
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
18-461 |
1.30e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 75.29 E-value: 1.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 18 RWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTV 97
Cdd:COG2807 16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 98 ISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRnRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVM 177
Cdd:COG2807 96 GLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 178 FAPVPVTLIGVFMAWRFLPLPVSRPAPyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfvire 257
Cdd:COG2807 175 AVWALLALLALLLWLPLLRRRPAAAAA----------------------------------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 258 rrARHPLVNIGLLRNPAFVYANLgAMALGLALFGS--TYLVPLFVQtaLEFTATEAGLLMLPAGIVLGMTFPLAGRLADR 335
Cdd:COG2807 202 --APAAASLRSLWRSPLAWLLTL-FFGLQSLLYYAvvAWLPPILRD--AGLSAATAGLLLSLFQLAGIPGSLLVPLLADR 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 336 LSARKLVIFGIVLFAMSAMLFAVSdieLAFGWLALWTVLGRIGIGFMLP-ALSTGALNPLAPEQLGAGSSTINFTRQLGG 414
Cdd:COG2807 277 LGDRRPLLLLLGLLGLAGLLGLLL---APGSLPWLWAVLLGLGQGGLFPlALTLIGLRARTPAEAAALSGMAQSVGYLLA 353
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 750170587 415 AFGVNIVALTIefgDHSGGiptigaFHTAWWLVAVFVAMAAIPVWKM 461
Cdd:COG2807 354 ALGPLLVGALH---DATGS------WTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
77-417 |
6.10e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.93 E-value: 6.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 77 WLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILA 156
Cdd:cd17489 53 RLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 157 PALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWrFLPLPVSRPAPyrfdfpglvllgiaiglsldtlnrlqelagqe 236
Cdd:cd17489 133 MALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF-LVKDPPPVAAE-------------------------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 237 vriaiggAVAAIALVLFVIRERRARHPLvnigllrnpafvyanLGAMALGLALFGSTYLVPLFVQTALeftATEAGLLML 316
Cdd:cd17489 180 -------EAEAGTRAFRRLVEKKVLPPA---------------LILFLASIAYGAISTFLPLYAAERG---ISNAGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 317 PAGIVLGMTFPLAGRLADRLSARKLVIFGIVLFAMSAMLFAVSDIELAFGWLAlwtVLGRIGIGFMLPALSTGALNPLAP 396
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAA---VLYGLGFGLLFPALQALAVDLVPP 311
|
330 340
....*....|....*....|.
gi 750170587 397 EQLGAGSSTINFTRQLGGAFG 417
Cdd:cd17489 312 HRRGAANGTFFIFFDLGIGLG 332
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
10-196 |
1.58e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 68.92 E-value: 1.58e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 10 RARYGERWRWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLA 89
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 90 TAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVD 169
Cdd:TIGR00895 87 WSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIP 166
|
170 180
....*....|....*....|....*..
gi 750170587 170 QWDWRYVMFAPVPVTLIGVFMAWRFLP 196
Cdd:TIGR00895 167 VFGWRSLFYVGGIAPLLLLLLLMRFLP 193
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
27-420 |
5.78e-12 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 67.65 E-value: 5.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 27 LGTMATVLSATVVNVALHDIMLEFGiRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFAT 106
Cdd:cd06179 5 LAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 107 SPEQLIAARIGQGAMAGLmQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQ----WDWRYVMFAPVP 182
Cdd:cd06179 84 SVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEAnaagWRWIFYINAIFN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 183 V-TLIGVFMAWRFLPLPVSRPAPYR-----FDFPGLVLLGIAIGLSLDTLNrlqeLAGQ-----EVRIAIGGAVAAIALV 251
Cdd:cd06179 163 AlALILLFFFYHPPPRPQLHGSSTRqklkrLDWVGLFLLIAGLVLFLLGLS----WGGNpypwsSAHVIAPLVIGGVLLI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 252 LFVIRERRAR--HPLVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLA 329
Cdd:cd06179 239 AFGLYEWKGTkdGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 330 GRLADRLS-ARKLVIFGIVLFAMSAMLFAV---SDIELAFGWLalwtVLGRIGIGFMLPALSTGALNPLAPEQLGAGSST 405
Cdd:cd06179 319 GLLLTKIKhIKWQLVAGFVLFTAFLALLALitpDNKALAIAFS----VLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGL 394
|
410
....*....|....*
gi 750170587 406 INFTRQLGGAFGVNI 420
Cdd:cd06179 395 LGSARALGGAVGTAI 409
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
24-404 |
7.16e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 66.83 E-value: 7.16e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 24 TVMLGTMATVLSATVVNVALHDIMLEF-GIRQGQVHWLAT--GFIAAMTTtmLASSWLLDHFGVRKTLATAMFLFTVISL 100
Cdd:cd17473 3 TLLLASTLTVMAGAAIAPALPAIAQHFvPNSELLVPLLLTlpALFIALFA--PLAGWLADRFGRKRLLIAGLLLYGIGGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 101 LGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDqWDWRYVmFAP 180
Cdd:cd17473 81 AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAP-FLV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 181 VPVTLIGVFMAWRFLPLPVSRpapyrfdfpglvllgiaiglsldtlnrlqelagqevriaiggavaaialvlfviRERRA 260
Cdd:cd17473 159 YLLALPVLILVLLFLPEPARK------------------------------------------------------SKSAA 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 261 RHPLVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARK 340
Cdd:cd17473 185 SPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 750170587 341 LVIFGIVLFAMSAMLFAVSDIelaFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSS 404
Cdd:cd17473 265 LLAIGFALMALGFLLLALASG---LWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMG 325
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
75-196 |
4.32e-11 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 60.74 E-value: 4.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 75 SSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVI 154
Cdd:TIGR00880 18 SGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGIA 97
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 750170587 155 LAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLP 196
Cdd:TIGR00880 98 LGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
49-198 |
7.27e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 63.41 E-value: 7.27e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 49 EFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPM 128
Cdd:cd17475 25 DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPG 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 129 GMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLPLP 198
Cdd:cd17475 105 GGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
22-174 |
8.53e-11 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 63.36 E-value: 8.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 22 VATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLL 101
Cdd:cd17323 1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 750170587 102 GGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWR 174
Cdd:cd17323 81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWR 153
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
40-427 |
1.43e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 62.78 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 40 NVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQG 119
Cdd:TIGR00881 15 ALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 120 AMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQ-WDWRYVMFAPVPVTLIgvfmaWRFLPLP 198
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAElYSWHWVFIVPGIIAII-----VSLICFL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 199 VSRPAPyrfdfpglvllgIAIGLSLDTLNRLQELAGQEVriaiggavaaialvlfVIRERRARHPLVNIGLLRNPAFVYA 278
Cdd:TIGR00881 170 LLRDSP------------QSCGLPPAEEMPNEEPDGDAE----------------KKEEELTKKQIFLQYVLLNKVLWYI 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 279 NLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLP---AGIVLGMtfpLAGRLADRLSARKLviFGIVLFAMSAML 355
Cdd:TIGR00881 222 SLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLyelGGLVGTL---LAGWLSDKLFNGRR--GPLAVFFMALII 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 750170587 356 FAVSDIELAFGWLALWTVLGRIGIGFML--PALSTG-ALNPLAPEQL-GAGSSTINFTRQLGGAFGVNIVALTIEF 427
Cdd:TIGR00881 297 VSLLVYWLNPAANPLMDLICLFALGFLVygPQMLIGvIASELAPKKAaGTAAGFVGFFAYLGGILAGLPLGYLADG 372
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
22-192 |
2.95e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 58.37 E-value: 2.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 22 VATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLL 101
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 102 GGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPV 181
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170
....*....|.
gi 750170587 182 PVTLIGVFMAW 192
Cdd:cd17365 161 VPPLILLPLLR 171
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
42-196 |
1.47e-08 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 56.62 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 42 ALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAM 121
Cdd:TIGR00710 27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 750170587 122 AGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLP 196
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP 181
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
46-198 |
2.06e-08 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 56.16 E-value: 2.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 46 IMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLM 125
Cdd:cd17371 25 LIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGE 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 750170587 126 QPMGMYLVFRIFPRNRRGQAMGI----YGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAwRFLPLP 198
Cdd:cd17371 105 WAAGAALMAEYVPARHRGKALGYvqsgWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIR-RFVKEP 180
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
65-194 |
2.20e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 2.20e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 65 IAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQ 144
Cdd:cd17474 245 VLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 750170587 145 AMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRF 194
Cdd:cd17474 325 ASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-195 |
3.16e-08 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 55.29 E-value: 3.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 62 TGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNR 141
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHR 313
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 750170587 142 RGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFL 195
Cdd:cd17489 314 RGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
18-195 |
4.88e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.59 E-value: 4.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 18 RWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTV 97
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 98 ISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVM 177
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170
....*....|....*...
gi 750170587 178 FAPVPVTLIGVFMAWRFL 195
Cdd:cd17312 161 LVPGIVGLVVAIILFFFL 178
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
78-178 |
2.27e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 52.65 E-value: 2.27e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 78 LLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMqPMGMYLVFRIFPRNRRGQAMGIYGMGVILAP 157
Cdd:cd17391 59 LADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYV-PNATALIASQTPKEKSGWALGTLSTGVVAGT 137
|
90 100
....*....|....*....|.
gi 750170587 158 ALGPVLGGFLVDQWDWRYVMF 178
Cdd:cd17391 138 LIGPLLGGFLADLFGIRNVFF 158
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
77-450 |
3.29e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 52.22 E-value: 3.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 77 WLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAmaGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILA 156
Cdd:cd17472 54 LLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVVMALLADLTREENRTKAMALIGASIGIA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 157 PALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLPLPVsrpapyrfdfpglvllgiaiglsldtlnrlqelagqe 236
Cdd:cd17472 132 FAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPP------------------------------------- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 237 vriaiggavaaialvlfVIRERRARHPLVNIGLLRNPAFVYANLGAMALGLALFGSTYLVPLFVqTALEFTATEAGLLML 316
Cdd:cd17472 175 -----------------KIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLL-TQLGGGKGQLWKVYL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 317 PAGIVLGMTFPLAGRLADRLSARKLVI-FGIVLFAMSAMLFAVSDieLAFGWLALWTVLGRIGIGFMLPALSTGALNPLA 395
Cdd:cd17472 237 PAILIGFILMVPFVIYAEKKGKMKQVFvSSILLIAVGFLLLLFAA--TSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAP 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 750170587 396 PEQLGAGSSTINFTRQLGGAFGVNIVALTIEFGDHSGGIPTIGAFHTAWWLVAVF 450
Cdd:cd17472 315 KEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFL 369
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
77-440 |
4.48e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.84 E-value: 4.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 77 WLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILA 156
Cdd:cd17329 57 RLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 157 PALGPVLGGFLVDQwDWRYVMFAPVPVTLIGVFMAWRFLPLPVSRPAPYRFDfPGLVLLGIAiglsldtlnrlqelagqe 236
Cdd:cd17329 137 VAIGPLLGGLLLLY-SFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKT-EILRGYKIV------------------ 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 237 vriaiggavaaialvlfvirerrarhplvniglLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAG-LLM 315
Cdd:cd17329 197 ---------------------------------LRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGlLLA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 316 LPAGIVLGMTFPLAgRLADRLSARKLVIFGIVLFAMSAMLFAVSdieLAFGWLALWTVLGRIGIGFMLPALSTGALNPLA 395
Cdd:cd17329 244 LNALLIVLLQFPVA-RLVERFRLRKILMIGILLFAIGFAVLAFA---NTLAVLILAMIVLTLGEMLVFPAVQTLVAALAP 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 750170587 396 PEQLGAGSSTINFTRQLGGAFGVNIVALTIEFGDHSGGIPTIGAF 440
Cdd:cd17329 320 PDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAAL 364
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
42-207 |
6.30e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 51.45 E-value: 6.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 42 ALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAM 121
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 122 AGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLP--LPV 199
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIPetLPK 172
|
....*...
gi 750170587 200 SRPAPYRF 207
Cdd:PRK11102 173 ERRQPFHL 180
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
38-375 |
9.85e-07 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 50.70 E-value: 9.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 38 VVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIG 117
Cdd:cd17328 17 TIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 118 QGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQW-DWRYVMFAPVPVTLIGVFMAWRFLP 196
Cdd:cd17328 97 VGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVR 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 197 LPVSRPApyrfdfpglvllGIAIGLSLDTLNRLQELAgqevriaiggavaaialvlfvirerrarhplvniGLLRNPAFV 276
Cdd:cd17328 177 EPPRGAA------------EGGVMAKSTATSFLADLK----------------------------------ALAKNPSFI 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 277 YANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMT----FPLAGRLADRLS-----ARKLV----I 343
Cdd:cd17328 211 LSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRrktprADPLVcavgL 290
|
330 340 350
....*....|....*....|....*....|..
gi 750170587 344 FGIVLFAMSAMLFAVSDIELAFGWLALWTVLG 375
Cdd:cd17328 291 LAAAPFLFLALVLALSNLLLAWVLLFLGEFLL 322
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-194 |
2.82e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.47 E-value: 2.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 19 WLAVATVMLGTMATVLSATVVNVALHDImleFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVI 98
Cdd:COG0738 213 LLGGLAIFLYVGAEGAIGDWLPLYLKDV---LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 99 SLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGvILAPALGPVLGGFLVDQWDWRYVMF 178
Cdd:COG0738 290 LLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMG-IVGGAIGPPLIGFLADAFGLRAAFL 368
|
170
....*....|....*.
gi 750170587 179 APVPVTLIGVFMAWRF 194
Cdd:COG0738 369 VPLVCYLLILLLALAL 384
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
77-195 |
3.04e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 49.14 E-value: 3.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 77 WLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGI----YGMG 152
Cdd:cd17316 58 YLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLlqsgWALG 137
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 750170587 153 VILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFL 195
Cdd:cd17316 138 ALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLRRRTL 180
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
269-463 |
4.11e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.13 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 269 LLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIFGIVL 348
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 349 FAMSAMLFAVSDIElAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQL-------GAGSSTINFTRQLGGAFGVNIV 421
Cdd:COG2211 304 AALGLLLLFFLGPG-NLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALA 382
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 750170587 422 ALTIE-FGDHSGGIPTIGAFHT----AWWLVAVFVAMAAIPVWKMRV 463
Cdd:COG2211 383 GLLLAlFGYVAGAAQSPSALTGirllFFLLPAVLLLLAALLLLFYPL 429
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
9-156 |
6.47e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.05 E-value: 6.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 9 LRARYGERWRWLAVATVMLGTMATVLSATVVNVALHDIMLE-FGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKT 87
Cdd:COG2814 196 LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL 275
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 750170587 88 LATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILA 156
Cdd:COG2814 276 LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
271-461 |
7.52e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 7.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 271 RNPAFVYANLGAMALGLALFGSTYLVPLFVQtALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIFGIVLFA 350
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAA-DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 351 MSAMLFAVSDielAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFGVNIVALTIEFGDh 430
Cdd:COG2814 87 LGSLLCALAP---SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG- 162
|
170 180 190
....*....|....*....|....*....|.
gi 750170587 431 sggiptigaFHTAWWLVAVFVAMAAIPVWKM 461
Cdd:COG2814 163 ---------WRWVFLVNAVLALLALLLLLRL 184
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
41-174 |
8.78e-06 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 47.71 E-value: 8.78e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 41 VALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGA 120
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 750170587 121 MAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWR 174
Cdd:PRK10473 104 GAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFPWQ 157
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
19-192 |
9.71e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 47.54 E-value: 9.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 19 WLAVATVMLGTMATVLSATVVNVALHDImleFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVI 98
Cdd:cd17324 201 RLAYLITFLLFGGFFALYTYLAPFLTDV---PGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAAL 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 99 SLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRrGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMF 178
Cdd:cd17324 278 LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGW 356
|
170
....*....|....
gi 750170587 179 APVPVTLIGVFMAW 192
Cdd:cd17324 357 VGAALLLLALLLAL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
18-219 |
1.05e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 47.54 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 18 RWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTV 97
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 98 ISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRR---GQAMGIYGMGVILAPALGPVL-GGFLVDQWDW 173
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLLiLLGLSLSWHL 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 750170587 174 RYVMFApVPVTLIGVFMAWRFLPLPVSRPAPYR---------FDFPGLVLLGIAI 219
Cdd:COG0738 166 PYLILA-VLLLLLALLFLRSKLPEIEEEEEEAAgsaaslkslLKNPRLLLGGLAI 219
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
12-194 |
1.87e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.84 E-value: 1.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 12 RYGERWRWLAVATVMLGTMATVLSATVVNVALHdIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATA 91
Cdd:cd06173 202 RYLRRSPLLRLLLLALALFALLGGALTVLLPLL-AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIG 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 92 MFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQW 171
Cdd:cd06173 281 ALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL 360
|
170 180
....*....|....*....|...
gi 750170587 172 DWRYVMFAPVPVTLIGVFMAWRF 194
Cdd:cd06173 361 GLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
22-196 |
2.39e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 46.39 E-value: 2.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 22 VATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLL 101
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 102 GGFATSPEQ--LIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFA 179
Cdd:cd17380 81 TPLLAYSSLplLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
|
170
....*....|....*..
gi 750170587 180 PVPVTLIGVFMAWRFLP 196
Cdd:cd17380 161 FGLLGLLWALVWLIYLP 177
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
43-197 |
2.95e-05 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 46.04 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 43 LHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMA 122
Cdd:PRK03545 32 LSDIAQSFHMQTAQVGLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAH 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 750170587 123 GLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLPL 197
Cdd:PRK03545 112 AIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALITLLLLIKLLPL 186
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
20-206 |
3.54e-05 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 46.05 E-value: 3.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 20 LAVATVMLGTMATvlsaTVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVIS 99
Cdd:PRK11652 12 MLVLLVAVGQMAQ----TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 100 LLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYV-MF 178
Cdd:PRK11652 88 LVALFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACyLF 167
|
170 180
....*....|....*....|....*...
gi 750170587 179 APVPVTLIGVFMAWRFlplPVSRPAPYR 206
Cdd:PRK11652 168 LLLLGAGVTFSMARWM---PETRPADAR 192
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
64-196 |
5.71e-05 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 45.33 E-value: 5.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 64 FIAAMTTTMLASSWLlDHFGVRKTLATAMFLFTVISLLGGFA---TSPEQLIAARIGQG-AMAGLMQPMGMYLVfRIFPR 139
Cdd:cd17357 59 FIGGAIGSFISAFLA-NRFGRKNGLLISNALLVVSSLLMFLSksaKSPELLIFGRFLVGiACGLSTGFVPMYLQ-EISPS 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 750170587 140 NRRGQAMGIYGMGVILAPALGPVLG--GFLVDQWDWRYVMFAPVPVTLIGVFmAWRFLP 196
Cdd:cd17357 137 ELRGALGSLTQIGVTLGILLGQVFGlpSVLGTETLWPYLLFFPGIPALLQLA-ALPFFP 194
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
280-462 |
5.77e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 5.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 280 LGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARK------LVIFGIVLFAMSA 353
Cdd:COG2211 17 LGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwILIGAIPLALSFV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 354 MLFAVSDIE--LAFGWLALWTVLGRIGIG-FMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFGvniVALTIEFGDH 430
Cdd:COG2211 97 LLFTAPDLSptGKLIYALVTYLLLGLAYTlVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLA---SVLPPPLVAA 173
|
170 180 190
....*....|....*....|....*....|..
gi 750170587 431 SGGIPTIGAFHTAWWLVAVFVAMAAIPVWKMR 462
Cdd:COG2211 174 FGGDAALGYRLTALIFAVLGLLAFLLTFFGTK 205
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
46-169 |
7.71e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.95 E-value: 7.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 46 IMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTV-ISLLGGFATSPEQLIAARIGQGAMAGL 124
Cdd:cd17355 236 YLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALgLALLLLLPFPPLALLLFAALFGLGWGA 315
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 750170587 125 MQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVD 169
Cdd:cd17355 316 TVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYD 360
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
10-195 |
9.13e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.56 E-value: 9.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 10 RARYGERWRWLAVATVMLGTMATVLSATVVNVALHDIMLEFgIRQ----GQVHWLATGFIAAMT--TTMLASSWL---LD 80
Cdd:cd17391 187 MVSTKEVWNSVPNPSLLISLFVTTFIIQLANQSIEPILTLY-IRQlmgdASNLAFISGLVFSATgvSSLLSAPRLgklGD 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 81 HFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALG 160
Cdd:cd17391 266 RIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAG 345
|
170 180 190
....*....|....*....|....*....|....*
gi 750170587 161 PVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFL 195
Cdd:cd17391 346 PLLGSAIAAHFGYRAVFVVTALLVLLNAIWSFIFL 380
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
38-221 |
9.36e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 9.36e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 38 VVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIG 117
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 118 QGAMAGLMQPMGMYLVFRIFPrNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLPL 197
Cdd:cd17478 94 AGIGSAAFHPEGARLASQAAG-GRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPL 172
|
170 180 190
....*....|....*....|....*....|....
gi 750170587 198 ----------PVSRPAPYRFDFPGLVLLGIAIGL 221
Cdd:cd17478 173 kkpeakkaaaKSSARSTLKGVWRALLLLLIIVFL 206
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-204 |
1.24e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.09 E-value: 1.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 21 AVATVMLGTMATVLSATVVNVALHDImlefGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISL 100
Cdd:cd17477 1 LLLSVALLGLGSGLLLPLLSLRLERE----GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 101 LGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFlVDQWDWRYVMFAP 180
Cdd:cd17477 77 LLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL-VGTAGALPFLIAA 155
|
170 180
....*....|....*....|....
gi 750170587 181 VPVTLIGVFMAWRFLPLPVSRPAP 204
Cdd:cd17477 156 VLLLLALVPLLLTRRAAPEIEEAE 179
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
19-191 |
1.37e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 44.08 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 19 WLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVI 98
Cdd:cd17352 2 WVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 99 SLLGGFATSPEQLIAAR-IGQGAMAGLMQPMGMYLVFRIFpRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVM 177
Cdd:cd17352 82 LLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170
....*....|....
gi 750170587 178 FAPVPVTLIGVFMA 191
Cdd:cd17352 161 LILGGLCLNLCVCG 174
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
23-169 |
1.46e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.75 E-value: 1.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 23 ATVMLGTMATVLSATVVnvalhdIMLEFGIRQGQVHWLATGF-IAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLL 101
Cdd:cd17490 204 ILQQMITFSTTFGFTPL------IAKQLGASSFQLGLLSIIYlLPNALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFL 277
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 750170587 102 GGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMG----IYGMGVIlapaLGPVLGGFLVD 169
Cdd:cd17490 278 IPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGffqaIYALGMF----LGPVLVGIISE 345
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
78-201 |
1.70e-04 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 43.76 E-value: 1.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 78 LLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMqPMGMYLVFRIFPRNRRGQAMGIYGMGVILAP 157
Cdd:PRK09874 77 LADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGFV-PNANALIATQVPRNKSGWALGTLSTGGVSGA 155
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 750170587 158 ALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLP---LPVSR 201
Cdd:PRK09874 156 LLGPLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRenfQPVSK 202
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
280-456 |
1.96e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 43.67 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 280 LGAMALGLALFGSTYLVPLFV----QTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIFGIVLFAMSAML 355
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTFAlsyaTQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFP 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 356 FavsdielaFGWLA----LWTVLGRIGIGFMLPALSTGALNPLAPEQLGA-----GSStinFTRQLGGAFGvnivaltie 426
Cdd:cd17369 311 F--------FWLLDtgstWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTrvrytGAS---LGYQLGAILG--------- 370
|
170 180 190
....*....|....*....|....*....|....*
gi 750170587 427 fgdhsGGIPTIGA-----FHTAWWLVAVFVAMAAI 456
Cdd:cd17369 371 -----GGFAPLIAtalvaATGSWWPVALYLAALAV 400
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
19-168 |
2.14e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 2.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 19 WLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVhwlATGFIAAMTTTMLASS----WLLDHFGVRKTLATAMFL 94
Cdd:cd17473 196 WKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAAL---IGLALAIASLAGAIGAllfgRLKRRLGKRRLLAIGFAL 272
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 750170587 95 FTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLV 168
Cdd:cd17473 273 MALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLV 346
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
58-174 |
2.23e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 2.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 58 HWLATGFIAAMTTTMLASS-------WLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAAR--IGQGAMAGLMQPM 128
Cdd:cd17355 34 GWSRAVISLAFTVGLLAFGlaqpfvgRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWglLGGGGAGTLAAVA 113
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 750170587 129 GMYLVFRIFPRnRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWR 174
Cdd:cd17355 114 FATVAAWWFER-RRGLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
77-381 |
2.29e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 43.39 E-value: 2.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 77 WLL----DHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMG 152
Cdd:PRK15402 66 WLLgplsDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIKITALMANV 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 153 VILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLPLPVSRpapyrfdfpglvllgiaiglsldtlnrlqel 232
Cdd:PRK15402 146 ALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETAGR------------------------------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 233 agqevriaiggavaaialvlfvireRRARHPLVNIG-----LLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFT 307
Cdd:PRK15402 195 -------------------------VGEKLSLKELGrdyklVLKNRRFVAGALALGLVSLPLLAWIALSPVILISGEQLS 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 750170587 308 ATEAGLLMLP--AGIVLGMTfpLAGRLADRLSARKLVIFGIVLFAMSAMLFAVSdiELAFGWLALWTVLGRIGIGF 381
Cdd:PRK15402 250 SYEYGLLQVPvfGALIAGNL--TLARLTSRRPLRSLIRMGLWPMVAGLLLAALA--TVISSHAYLWLTAGLSLYAF 321
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
17-169 |
2.68e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 2.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 17 WRWLAVATVMLGTMATVLSATVVNVALHdimlEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFT 96
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFKY----VLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 97 VISLLGGFA--TSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFP-------RNRRGQAMGIYGMGVILAPALGPVLGGFL 167
Cdd:COG2211 306 LGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
..
gi 750170587 168 VD 169
Cdd:COG2211 386 LA 387
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
22-193 |
2.75e-04 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 43.16 E-value: 2.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 22 VATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLL 101
Cdd:cd17488 5 LASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINIL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 102 GGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPV 181
Cdd:cd17488 85 FGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPG 164
|
170
....*....|...
gi 750170587 182 PVTL-IGVFMAWR 193
Cdd:cd17488 165 IIAIlMGIVLCWR 177
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
59-439 |
2.94e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.99 E-value: 2.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 59 WLATGFIAAMTTTMLASSW---LLDHFGVRKTLATAMFLFTVISLLGGFAT-----SPEQLIAARIGQGAMAGLMQPMGM 130
Cdd:cd06173 35 LVGLVLAAFFLPFLLFSPFagvLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 131 YLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLPLPVSRPAPYRFDFP 210
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 211 GLVLLGIAIglsldtlnrlqelagqevriaiggavaaialvlfvirerrarhplvnigLLRNPAFVYANLGAMALGLALF 290
Cdd:cd06173 195 RDLREGLRY-------------------------------------------------LRRSPLLRLLLLALALFALLGG 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 291 GSTYLVPLFVQTALEFTATEAGLLM--LPAGIVLGMTfpLAGRLADRLSARKLVIFGIVLFAMSAMLFAVSdieLAFGWL 368
Cdd:cd06173 226 ALTVLLPLLAKEVLGGGAAGYGLLLaaFGVGALLGAL--LLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWLL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 750170587 369 ALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFGVNIVALTIEFGDHSGGIPTIGA 439
Cdd:cd06173 301 LAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGA 371
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
77-196 |
3.36e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 42.64 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 77 WLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILA 156
Cdd:PRK11551 72 RLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFG 151
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 750170587 157 PALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLP 196
Cdd:PRK11551 152 GALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLP 191
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
73-183 |
3.88e-04 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 42.51 E-value: 3.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 73 LASSWLL----DHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGI 148
Cdd:PRK15403 65 MALQWLLgplsDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAI 144
|
90 100 110
....*....|....*....|....*....|....*
gi 750170587 149 YGMGVILAPALGPVLGGFLVDQWDWRyVMFAPVPV 183
Cdd:PRK15403 145 ITSIVLVAPIIGPLSGAALMHFVHWK-VLFAIIAV 178
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
78-192 |
3.99e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 42.72 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 78 LLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGL-MQPMGMYlVFRIFPRNRRGQAMGIYGMGVILA 156
Cdd:cd17362 62 LIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLaMHAAPVY-IAETSPSHIRGLLVSLKELFIVLG 140
|
90 100 110
....*....|....*....|....*....|....*...
gi 750170587 157 PALGPVLGGFLVD-QWDWRYVM-FAPVPVTLIGVFMAW 192
Cdd:cd17362 141 ILLGYVSGYAFADvVGGWRYMYgLAAPPALLLGIGMWF 178
|
|
| PRK05122 |
PRK05122 |
major facilitator superfamily transporter; Provisional |
296-381 |
5.49e-04 |
|
major facilitator superfamily transporter; Provisional
Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 42.18 E-value: 5.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 296 VPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIFGIVLFAMSAMLFAVSDIELAFGWLAL-WTVL 374
Cdd:PRK05122 38 LPGYVHDQLGFSAFLAGLVISLQYLATLLSRPHAGRYADTLGPKKAVVFGLCGCALSGLLYLLAGLLAAWPVLSLlLLLL 117
|
....*..
gi 750170587 375 GRIGIGF 381
Cdd:PRK05122 118 GRLLLGI 124
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
287-421 |
7.23e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.81 E-value: 7.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 287 LALFGSTYL----VPLFVQTaLEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIFGIVLFAMSAMLFAVSDie 362
Cdd:cd17489 6 FFFFLSFYLllpvLPLYAHD-LGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT-- 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 750170587 363 lAFGWLALWTVLGRIGIGFMLPALSTGALNPLAPEQLGAGSS----TINFTRQLGGAFGVNIV 421
Cdd:cd17489 83 -SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGyyglATTLAMALGPALGLFLY 144
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
48-171 |
7.99e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 7.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 48 LEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFA-TSPEQLIAARIGQGAMAGLMQ 126
Cdd:cd17477 216 LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVpGLPLALLVLLFLWGGAAGPLY 295
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 750170587 127 PMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLGGFLVDQW 171
Cdd:cd17477 296 TLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAF 340
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
17-194 |
9.03e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.40 E-value: 9.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 17 WRWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFT 96
Cdd:COG2807 212 WRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLG 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 97 VISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRR-GQAMG-IYGMGVILApALGPVLGGFLVDQW-DW 173
Cdd:COG2807 292 LAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEaAALSGmAQSVGYLLA-ALGPLLVGALHDATgSW 370
|
170 180
....*....|....*....|.
gi 750170587 174 RYVMFAPVPVTLIGVFMAWRF 194
Cdd:COG2807 371 TAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
78-358 |
1.18e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 41.05 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 78 LLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGlMQPMGMyLVFRIFPRNRRGQAMG----IYGMGV 153
Cdd:cd17331 58 FGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHA-MQAAQM-VVTDLTDPGERAAALGrlglSYGIGM 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 154 IlapaLGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLPLPvsrpapyrfdfpglvllgiaiglsldTLNRLQELA 233
Cdd:cd17331 136 V----VGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSN--------------------------TKSKREKEA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 234 GQEVRIAIGGAVAAIALVLfvirerraRHPLVnigllrnpAFVYANLGAMALGLALFGSTYlvPLFVQTALEFTATEAGL 313
Cdd:cd17331 186 KESASPPSVFNLKEILRLL--------RLPGV--------AFLLLVKLLSGLPIGMFQSMF--SLVAMDFFGLTPEENGY 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 750170587 314 LMLPAGIvLGMTFP--LAGRLADRLSARKLVIFGIVLFAMSAMLFAV 358
Cdd:cd17331 248 LMSYAGV-LGMVVQglLVGPLTKRFGERSLLKLSVALLAIGYLLLAF 293
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
70-199 |
1.41e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 40.68 E-value: 1.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 70 TTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFAT--SPEQLIAARIGQGAMAGLMQPmGMY-LVFRIFPRNRRGQAM 146
Cdd:cd17318 71 LTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFP-AMHaLWAKWAPPLERSRLT 149
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 750170587 147 GIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIgVFMAWRFLPLPV 199
Cdd:cd17318 150 SIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLL-WCLLWFFLVLPV 201
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
295-428 |
1.71e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.67 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 295 LVPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIFGIVLFAMSAMLFAVSDIELAFGWLALWTVL 374
Cdd:cd17329 21 FMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGF 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 750170587 375 GRigiGFMLPALSTGALNPLAPEQLGAGSSTINFTRQLGGAFGVNIVALTIEFG 428
Cdd:cd17329 101 GG---GLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS 151
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
73-170 |
2.39e-03 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 39.92 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 73 LASSWLLDHFGVRKTLATAMFLFTV-ISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIY-G 150
Cdd:pfam12832 254 FYAHRLLRRFGHRNLLIIALLLTALrWLLYAFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIFPGSLQGTGQALYsG 333
|
90 100
....*....|....*....|
gi 750170587 151 MGVILAPALGPVLGGFLVDQ 170
Cdd:pfam12832 334 LYFGLGGALGSLIGGQLWDL 353
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
49-196 |
3.41e-03 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 39.49 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 49 EFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAAR----IGQGAMAGL 124
Cdd:PRK11043 35 DLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRfvqaVGVCSAAVI 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 750170587 125 MQPMgmylvfrIFPRNRRGQAMGIYGM---GVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWRFLP 196
Cdd:PRK11043 115 WQAL-------VIDRYPAQKANRVFATimpLVALSPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKP 182
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
64-176 |
3.66e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 64 FIAAMTTTMLAS---SWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRN 140
Cdd:cd17370 240 YALFNLVYALAAypaGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAE 319
|
90 100 110
....*....|....*....|....*....|....*.
gi 750170587 141 RRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYV 176
Cdd:cd17370 320 LRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAA 355
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
17-174 |
3.77e-03 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 39.72 E-value: 3.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 17 WRWLAVATVMLGTMATVLSATVVNVALHDIMLEFGIRQGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFT 96
Cdd:TIGR00892 16 WGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGGLLAS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 97 VISLLGGFATSPEQL--IAARIGQGAMAGLMQP----MGMYLVfrifprNRRGQAMGIYGMGVILAPALGPVLGGFLVDQ 170
Cdd:TIGR00892 96 LGMILASFSSNVIELylTAGFITGLGLAFNFQPsltmLGKYFY------RRRPLANGLAMAGSPVFLSTLAPLNQYLFES 169
|
....
gi 750170587 171 WDWR 174
Cdd:TIGR00892 170 FGWR 173
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
38-196 |
4.38e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 39.09 E-value: 4.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 38 VVNVALHDIMLEFGIR--QGQVHWLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAAR 115
Cdd:cd17315 15 VINGALLYIAKDLGFGlsTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGR 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 116 IGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIYGMGVILAPALGPVLG-GFLVDQWDWRYVMFAPVPVTLIGVFMAWRF 194
Cdd:cd17315 95 FLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGlALSLSPPGWWRLMFALAAVPALLQLLLMFF 174
|
..
gi 750170587 195 LP 196
Cdd:cd17315 175 LP 176
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
59-167 |
4.78e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 39.15 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 59 WLATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFP 138
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYK 124
|
90 100
....*....|....*....|....*....
gi 750170587 139 RNRRGQAMGIYgmgvILAPALGPVLGGFL 167
Cdd:cd17327 125 REEQAKRIAFF----YAAAGLGSIFGGLL 149
|
|
| OATP |
pfam03137 |
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ... |
269-358 |
4.98e-03 |
|
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
Pssm-ID: 460821 [Multi-domain] Cd Length: 526 Bit Score: 39.11 E-value: 4.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 269 LLRNPAFVYANLGAMALGLALFGSTYLVPLFVQTALEFTATEAGLLM----LPA---GIVLGMTfpLAGRLadRLSARKL 341
Cdd:pfam03137 242 LLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFGLSASTANLLTgvvaIPGaalGILLGGL--IIKKF--KLSAKGL 317
|
90
....*....|....*..
gi 750170587 342 VIFGIVLFAMSAMLFAV 358
Cdd:pfam03137 318 AKFNVITSLVSLLLSLL 334
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
60-193 |
5.57e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 5.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 60 LATGFIAAMTTTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPR 139
Cdd:cd17330 216 LALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPS 295
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 750170587 140 NRRGQAMGIYGMGVILAPALGPVLGGFLVDQWDWRYVMFAPVPVTLIGVFMAWR 193
Cdd:cd17330 296 KEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
255-382 |
5.82e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.82 E-value: 5.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 255 IRERRARHPLVNIGLLRNPAFVYANLGAMALGLALFGS--TYLvPLFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRL 332
Cdd:cd17367 204 IAESNEASAGTLRELRRHPRELLLVVGLTAGGTLAFYTwtTYL-QKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRL 282
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 750170587 333 ADRLSARKLVIFGIVLF--AMSAMLFAVSDIELAFGWLALWTVLGRIGIGFM 382
Cdd:cd17367 283 SDRIGRRPLLLFFGIGGtlATVPLLSALDHTDSPYTAFALVLVGLVFLSGYT 334
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
274-463 |
6.88e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.68 E-value: 6.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 274 AFVYANLGAMALGLALFGStyLVPlFVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIFGIVLFAMSA 353
Cdd:COG0738 11 IAIYLLFFLWGFATALWGP--LIP-ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 354 MLFAVSDielAFGWLALWTVLGRIGIGFMLPALSTGALNpLAPEQLGAGSSTINFTRQLGGAFGVNIVALTIEFGDHSgg 433
Cdd:COG0738 88 LLFALAP---SYPLLLLALFLLGLGLGLLDVAANPYVAA-LGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL-- 161
|
170 180 190
....*....|....*....|....*....|
gi 750170587 434 iptigAFHTAWWLVAVFVAMAAIPVWKMRV 463
Cdd:COG0738 162 -----SWHLPYLILAVLLLLLALLFLRSKL 186
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
70-171 |
8.23e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 38.33 E-value: 8.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 70 TTMLASSWLLDHFGVRKTLATAMFLFTVISLLGGFATSPEQLIAARIGQGAMAGLMQPMGMYLVFRIFPRNRRGQAMGIY 149
Cdd:cd17335 248 PFFFFSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLL 327
|
90 100
....*....|....*....|...
gi 750170587 150 -GMGVILAPALGPVLGGFLVDQW 171
Cdd:cd17335 328 qGLYFGLGGGLGSLIGGYLYEAF 350
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
299-385 |
8.70e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 38.37 E-value: 8.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 750170587 299 FVQTALEFTATEAGLLMLPAGIVLGMTFPLAGRLADRLSARKLVIFGIVLFAMSAMLFAVSdieLAFGWLALWTVLGRIG 378
Cdd:cd17475 21 FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV---GSYPVLLVLLFLVGAG 97
|
....*..
gi 750170587 379 IGFMLPA 385
Cdd:cd17475 98 YGSVQPG 104
|
|
| |
