|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
10-499 |
0e+00 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 1011.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 10 ITLRDVTIIDDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMVAALATFSVPFLIRPLGGLFFGML 89
Cdd:PRK10642 1 ITLRDVTIIDDGKLRKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMIAALATFSVPFLIRPLGGLFFGML 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 90 GDKYGRQKILAITIVIMSISTFCIGLIPSYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLD 169
Cdd:PRK10642 81 GDKYGRQKILAITIVIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 170 FGSIAGFVLGAGVVVLISTVVGEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEQGDRQGLQEGPKIS 249
Cdd:PRK10642 161 FGSIAGFVLGAGVVVLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFQQHVDKLEQGDREGLQDGPKVS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 250 FKEIATKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVI 329
Cdd:PRK10642 241 FKEIATKHWRSLLTCIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPVMGLLSDRFGRRPFVI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 330 MGSIALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAW 409
Cdd:PRK10642 321 LGSVALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAW 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 410 LVESSQNLMMPAYYLMVIAVVGLITGVTMKETANQPLKGATPAASDIQEAKEILGEHYDNIEQKIEDIDQEIAELQVKRT 489
Cdd:PRK10642 401 LVESTQNLMMPAYYLMVVAVIGLITGVTMKETANRPLKGATPAASDIQEAKEILVEHYDNIEQKIDDIDQEIAELQAKRT 480
|
490
....*....|
gi 749612430 490 RLVQQHPRID 499
Cdd:PRK10642 481 RLVQQHPRID 490
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
27-442 |
0e+00 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 588.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17366 1 VKAAALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTAQLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 107 SISTFCIGLIPSYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLI 186
Cdd:cd17366 81 AASTFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 187 STVVGEDNFLEWGWRIPFFLALPLGLIGLYLRhaleetpafqqhvdkleqgdrqglqegpkisfkeiatkhwRSLLACIG 266
Cdd:cd17366 161 TLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLR----------------------------------------RPLLICIG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 267 LVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFILI 346
Cdd:cd17366 201 LVLVFNVTNYMLLSYMPSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLAGLLVLAVPAFLLM 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 347 NSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAA-WLVESSQNLMMPAYYLM 425
Cdd:cd17366 281 NSGSIAAIFIGLLVLGLLLSCYTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVAsWLVSATGNPLMPAYYLM 360
|
410
....*....|....*..
gi 749612430 426 VIAVVGLITGVTMKETA 442
Cdd:cd17366 361 VAAVVGLVAVLFLTETA 377
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
33-432 |
3.63e-165 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 472.53 E-value: 3.63e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 33 GNAMEWFDFGVYGFVAYALGKVFFPGA-DPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTF 111
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSgDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 112 CIGLIPSYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTVVG 191
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 192 EDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEQgdrqglqegPKISFKEIATKHWRSLLACIGLVIAT 271
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKK---------KRGPIAETLTKHRKPFLLGLGLVIAT 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 272 NVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAF-ILINSNV 350
Cdd:TIGR00883 232 TTTFYLITTYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLmALLDSGS 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 351 IGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLV-AGLTPTLAAWLVESSQNLMMPAYYLMVIAV 429
Cdd:TIGR00883 312 FTLFFFLVLGMALIGGMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIfGGFAPYIAAALVAMTGDWYAIGYYLAALAL 391
|
...
gi 749612430 430 VGL 432
Cdd:TIGR00883 392 IGL 394
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
24-437 |
1.06e-135 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 398.05 E-value: 1.06e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 24 RKAITAASLGNAMEWFDFGVYGFVAyAL--GKVFFPGADPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAI 101
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFIYGTAA-ALvfNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 102 TIVIMSISTFCIGLIPSYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAG 181
Cdd:cd17369 80 TLLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 182 VVVLISTVVGEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEQgdrqglqegPKISFKEIATKHWRSL 261
Cdd:cd17369 160 VFLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQV---------VRAPLVEVLRRHWRAL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 262 LACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIP 341
Cdd:cd17369 231 LLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 342 AFILINS-NVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNI-SVLVAGLTPTLAAWLVESSQNLMM 419
Cdd:cd17369 311 FFWLLDTgSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLgAILGGGFAPLIATALVAATGSWWP 390
|
410
....*....|....*...
gi 749612430 420 PAYYLMVIAVVGLITGVT 437
Cdd:cd17369 391 VALYLAALAVISLVAALF 408
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
27-442 |
3.93e-104 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 317.31 E-value: 3.93e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17367 1 ILGGSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPTVALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 107 SISTFCIGLIPSYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLI 186
Cdd:cd17367 81 AAGSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 187 STVVGEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEQgdRQGLQEGPKisfkeiatKHWRSLLACIG 266
Cdd:cd17367 161 QHTLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEAIAESNEA--SAGTLRELR--------RHPRELLLVVG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 267 LVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFILI 346
Cdd:cd17367 231 LTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSAL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 347 NSNVIGLIFAGLLMLA-VILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLT-PTLAAWLVessQNLMMPAY-- 422
Cdd:cd17367 311 DHTDSPYTAFALVLVGlVFLSGYTSINAVVKAELFPTHVRALGVGLPYALAVAIFGGTaPYVALWLK---SIGHEWVFfw 387
|
410 420
....*....|....*....|
gi 749612430 423 YLMVIAVVGLITGVTMKETA 442
Cdd:cd17367 388 YVAGLIAISLVVYLRMPETR 407
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
27-442 |
9.84e-100 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 305.84 E-value: 9.84e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17368 1 ILAATSGNALEFFDFGVYGFFAVYIGRLFFPSGSEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 107 SISTFCIGLIPSYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLI 186
Cdd:cd17368 81 ALGTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 187 STVVGEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEqgdrqglqegpKISFKEIATKHWRSLLACIG 266
Cdd:cd17368 161 SLTLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPT-----------RRELFALLANNRRIILLGML 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 267 LVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAF-IL 345
Cdd:cd17368 230 LVAGSTVTFYFTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFaWL 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 346 INSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLV-AGLTPTLAAWLVESSQNLMMPAYYL 424
Cdd:cd17368 310 TAAPSFGRLLLVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIfGGFAQFIVTWLIELTGSPLAPAWYL 389
|
410
....*....|....*...
gi 749612430 425 MVIAVVGLITGVTMKETA 442
Cdd:cd17368 390 MGAALLGLLATLMLRETA 407
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-436 |
1.22e-85 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 267.93 E-value: 1.22e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 27 ITAASLGNAMEWFDFGVYGFVAYALGKVFfpgaDPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 107 SISTFCIGLIPSyasigiwaPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLI 186
Cdd:cd17316 77 GLATLLIGLLPT--------PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 187 STVVGEDnfleWGWRIPFFLALPLGLIGLYLRhaleetpafqqhvdkleqgdrqglqegpkisfkeiatkhwRSLLACIG 266
Cdd:cd17316 149 IPLLSGD----WGWRILFLIGALPALLALLLR----------------------------------------RRTLLLIL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 267 LVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFILI 346
Cdd:cd17316 185 LWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 347 NSNVIgLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSQNLMMPAYYLMV 426
Cdd:cd17316 265 SGSPT-LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL 343
|
410
....*....|
gi 749612430 427 IAVVGLITGV 436
Cdd:cd17316 344 LAIVALIVAL 353
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
30-447 |
2.23e-82 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 262.59 E-value: 2.23e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 30 ASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMVAAL-----ATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIV 104
Cdd:pfam00083 5 AALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSLAALsvlsgLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 105 IMSISTFCIGlipsyASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVV 184
Cdd:pfam00083 85 LFVIGAVLQG-----AAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 185 LISTVVGednflEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEQGD----RQGLQEGPKISFKEIATKHWRS 260
Cdd:pfam00083 160 GLNKTSN-----SDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEARevlaKLRGVPDVDRELDEIKDSLEAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 261 --------------------LLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDhgvLIIIAIMIGMLFVQPIMGL-LS 319
Cdd:pfam00083 235 qeaekaswkelfstktrrqrLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS---FLVTIIVGVVNFVFTFIAIfLV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 320 DRFGRRPFVIMG----SIALFVLAIPAFILIN---SNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAA 392
Cdd:pfam00083 312 DRFGRRPLLLLGaagmAICFVILGIVALLGVSksdWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALA 391
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 749612430 393 FNISVLVAGLTPTLAAWLVESSQNLMMPAYYLMVIAVVGLITGVTMKETANQPLK 447
Cdd:pfam00083 392 TAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFIIFVFFFVPETKGRTLE 446
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
25-453 |
3.39e-82 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 261.42 E-value: 3.39e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 25 KAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIV 104
Cdd:PRK15075 15 RAILRVTSGNFLEMFDFFLFGFYATAIAKTFFPAGNEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 105 IMSISTFCIGLIPSYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVV 184
Cdd:PRK15075 95 IMASGTLLIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGY 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 185 LISTVVGEDNFLEWGWRIPFF---LALPLgliGLYLRHALEETPAFQQHvdkleqgdrqglQEGPkiSFKEIAT---KHW 258
Cdd:PRK15075 175 LLNQWLSPAQMAEWGWRIPFLigcLIVPF---IFLIRRSLEETEEFLAR------------KHRP--SMREIFRslaANW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 259 RSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVL 338
Cdd:PRK15075 238 RIVLAGMLMVAMTTVSFYLITVYTPTFGKTVLHLSAADSLLVTLCVGVSNFIWLPIGGALSDRIGRRPVLIAFTVLAILT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 339 AIPAFI-LINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLV-AGLTPTLAAWLVESSQN 416
Cdd:PRK15075 318 AYPALSwLVAAPSFARMLAVELWLSFLYGSYNGAMVVALTEVMPAEVRTAGFSLAYSLATAIfGGFTPAISTWLIHVTGD 397
|
410 420 430
....*....|....*....|....*....|....*..
gi 749612430 417 LMMPAYYLMVIAVVGLITGVTMKETANQPLKGATPAA 453
Cdd:PRK15075 398 KAAPGYWLSFAAVCGLIATLVLYRRRGARLQAAEAAA 434
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
24-441 |
3.04e-77 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 248.88 E-value: 3.04e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 24 RKAITAASLGNAMEWFDFGVYGFVA-YALGKVFFPGADPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAIT 102
Cdd:PRK09952 21 RRAALGSFAGAVVDWYDFLLYGITAaLVFNREFFPQVSPAMGTLAAFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLT 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 103 IVIMSISTFCIGLIPSYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGV 182
Cdd:PRK09952 101 VWMMGIATALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 183 VVLISTVVGEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEQGDRqglqegpKISFKEIATKHWRSLL 262
Cdd:PRK09952 181 VSLISMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKK-------RIPVIEALLRHPGAFL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 263 ACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDhgVLIIIAIMIGML--FVQPIMGLLSDRFGRRPFVIMGSIALFVLAI 340
Cdd:PRK09952 254 KIIALRLCELLTMYIVTAFALNYSTQNLGLPRE--LFLNIGLLVGGLscLTIPCFAWLADRFGRRRVYITGALIGTLSAF 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 341 PAFILINS-NVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNI-SVLVAGLTPTLAAWLVE-SSQNL 417
Cdd:PRK09952 332 PFFMALEAqSIFWIVFFSIMLANIAHDMVVCVQQPMFTEMFGASYRYSGAGVGYQVaSVVGGGFTPFIAAALVTyFGGSW 411
|
410 420
....*....|....*....|....
gi 749612430 418 MMPAYYLMVIAVVGLITGVTMKET 441
Cdd:PRK09952 412 HSVAIYLLAGCLISAMTALLMKDN 435
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
26-385 |
1.38e-65 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 218.14 E-value: 1.38e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 26 AITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVI 105
Cdd:PRK10406 23 AIVGASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTTTQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCM 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 106 MSISTFCIGLIPSYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVL 185
Cdd:PRK10406 103 MCFGSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 186 ISTVVGEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKlEQGDRQGLQegpkisfkeiatKHWRSLLACI 265
Cdd:PRK10406 183 LQQTLEDAELREWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALK-EAGSLKGLW------------RNRRAFIMVL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 266 GLVIATNVTYYMLLTYMPSYL--SHNLHYSEDHGvLIIIAIMIGMLfVQPIMGLLSDRFGRR-PFVIMGSIALfVLAIPA 342
Cdd:PRK10406 250 GFTAAGSLCFYTFTTYMQKYLvnTAGMHANVASG-IMTAALFVFML-IQPLIGALSDKIGRRtSMLCFGSLAA-LFTVPI 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 749612430 343 FILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPA-MFPTHIR 385
Cdd:PRK10406 327 LSALQNVSSPYAAFGLVMCALLIVSFYTSISGILKAeMFPAQVR 370
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
29-413 |
2.01e-42 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 155.15 E-value: 2.01e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 29 AASLGNAMEWFDFGVYGFVAYALGKVFfpGADPsvqmVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSI 108
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEF--GLDE----AEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 109 STFCIGLIPSYasigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDfgsiAGFVLGAGVVVLIST 188
Cdd:cd17371 77 FTLLCGFAQNY--------WQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQ----SGWAVGWLLATLLAA 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 189 VVGEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHvdkleQGDRQGLQEGPKISfkEIATKHWRSLLACIGLV 268
Cdd:cd17371 145 LLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAA-----RAARRHFADRPSLR--ELFSPPLLRTTLLASLL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 269 IAT-NVTYYMLLTYMPSYLSHNLHYSeDHGVLIIIAIMI-GMLFVQPIMGLLSDRFGRRPFVIMGSI--ALFVLAIPAFI 344
Cdd:cd17371 218 ATGaLGGYYGITTWLPSYLTGERGLS-FEGSAGYLVVTIlGGFLGYLAGGFLADRIGRRNNFALFALgsAISILLYFFLP 296
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749612430 345 LINSNVIGLIFAGLLMLAVILncftGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVES 413
Cdd:cd17371 297 LSPTLILILGFPLGFFASGPF----SGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATS 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
24-440 |
3.08e-38 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 143.87 E-value: 3.08e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFfpGADPSVQMVAalatFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF--GLSAAQLGLL----FAIPVLVGALLRIPLGFLVDRFGPRRVLLIGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 104 VIMSISTFCIGLIPSYasigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAGVV 183
Cdd:COG2223 78 LLLGIGLLLLALAVSY--------WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLA----AGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 184 VLISTVVgednFLEWGWRIPFFL-ALPLGLIGLYLRHALEETPAFQQHVDKleqgdrqglqeGPKISFKEIAtKHWRSLL 262
Cdd:COG2223 146 AFLAPLL----IAAFGWRNAFLIlGILLLVVAVLAWLFLRDPPAGAAAAAK-----------ASLRDQLEAL-RDPRFWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 263 ACIgLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPA 342
Cdd:COG2223 210 LSL-LYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 343 FILINSNVIGLIFAGLLMLAVILNCftGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSQNLMMPAY 422
Cdd:COG2223 289 ALALGSLWLFLVLFLLLGLALGGGN--GAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFL 366
|
410
....*....|....*...
gi 749612430 423 YLMVIAVVGLITGVTMKE 440
Cdd:COG2223 367 VFAVLALVALVLTLLLYR 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-402 |
1.04e-37 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 141.26 E-value: 1.04e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFfpGADPSvqmvAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADL--GASPA----QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 104 VIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 183
Cdd:COG2814 83 LLFALGSLLCALAPSLW--------LLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 184 VLISTVvgednfleWGWRIPFFLALPLGLIGLYLRH-ALEETPAfqqhvdkleqgdrqglQEGPKISFKEIATKHWRSLL 262
Cdd:COG2814 155 GLLADL--------FGWRWVFLVNAVLALLALLLLLrLLPESRP----------------AARARLRGSLRELLRRPRLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 263 ACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVImgsIALFVLAIPA 342
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL---IGLLLLALGL 287
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 343 FILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGL 402
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
24-433 |
1.28e-37 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 141.55 E-value: 1.28e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGAdpsvqmVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:COG2271 9 WRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSA------AQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 104 VIMSISTFCIGLIPSYASigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 183
Cdd:COG2271 83 LLWGLATLLFGFATSFWQ--------LLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 184 VLISTVvgednfleWGWRIPFFLALPLGLIGLYLRhaleetpafqqhvdkleqgdrqglqegpkisfkeiatkhwrsLLA 263
Cdd:COG2271 155 GWLLAA--------FGWRAAFLILGLPGLLLALLR------------------------------------------FWL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 264 CIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGsIALFVLAIPAF 343
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLA-IGLLLAALALL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 344 ILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSqNLMMPAYY 423
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLL 342
|
410
....*....|
gi 749612430 424 LMVIAVVGLI 433
Cdd:COG2271 343 LAALALLAAL 352
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
24-227 |
1.47e-31 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 123.00 E-value: 1.47e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGAdPSVQMVAALAtfsvpFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:COG0477 13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASS-AQLGWIVSAY-----LLGRAIGLLLFGRLGDRYGRKRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 104 VIMSISTFCIGLIPSyasigiwaPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 183
Cdd:COG0477 87 LLFGLASLLCGLAPS--------PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLG 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 749612430 184 VLISTVvgednfleWGWRIPFFLALPLGLIGLYLRHALEETPAF 227
Cdd:COG0477 159 GLLVAA--------LGWRWIFLINAPLGLLALVLRLRLPESRGL 194
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
72-379 |
2.35e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 107.28 E-value: 2.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIF 151
Cdd:cd17325 37 VAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYW--------QLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 152 VAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTVvgednfleWGWRIPFFLALPLGLIGLYLRHA-LEETPAFQQH 230
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA--------LGYRAPFLVCAALALLALVLALLlLPEPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 231 VDKLEQGDRQGLQEgpkisfkeiaTKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLF 310
Cdd:cd17325 181 RAVSAARLRSGLRL----------LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749612430 311 VQPIMGLLSDRFGRRPFVIMGSIaLFVLAIPAFILINSnvigliFAGLLMLAVILNCFTGVMASTLPAM 379
Cdd:cd17325 251 SQPPAGKLSDRIGRKPLILIGLL-LSAVALLLLPLATS------FWLLLLLLALLGLGLGLVFPATLAL 312
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
25-411 |
2.44e-24 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 104.75 E-value: 2.44e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 25 KAITAASLGNAMEWFDFGVYGFVAYALGKVFfpgadpSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIV 104
Cdd:TIGR00895 17 RAIILSFLIMLMDGYDLAAMGFAAPAISAEW------GLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 105 IMSISTFCIGLIPSYASIGIWapillllcKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAGVVV 184
Cdd:TIGR00895 91 LFSVFTLLCALATNVTQLLIL--------RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLM----FCGYPIGAAVGG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 185 LISTVVGEDnfleWGWRIPFFLA--LPLgLIGLYLRHALEETPAFQQhvdklEQGDRQGLQEGPKISFKEIA-------- 254
Cdd:TIGR00895 159 FLAGWLIPV----FGWRSLFYVGgiAPL-LLLLLLMRFLPESIDFLV-----SKRPETVRRIVNAIAPQMQAeaqsalpe 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 255 ----TKHWRSLLACI-------------GLVIATNVTYYMLLTYMPsYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGL 317
Cdd:TIGR00895 229 qkstQGTKRSVFKALfqgktaritvllwLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGW 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 318 LSDRFGRRP---FVIMGSIALFVLAIPAFilinsnviglIFAGLLMLAVILNCFT----GVMASTLPAMFPTHIRYSALA 390
Cdd:TIGR00895 308 LADRLGPRVtalLLLLGAVFAVLVGSTLF----------SPTLLLLLGAIAGFFVnggqSGLYALMALFYPTAIRATGVG 377
|
410 420
....*....|....*....|.
gi 749612430 391 AAFNISVLVAGLTPTLAAWLV 411
Cdd:TIGR00895 378 WAIGIGRLGAIIGPILAGYLL 398
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
72-404 |
4.62e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 102.88 E-value: 4.62e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIF 151
Cdd:pfam07690 38 LTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW--------LLLVLRVLQGLGAGALFPAALAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 152 VAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTVvgednfleWGWRIPFFLALPLGLIGLYLRHALEETPafqqhv 231
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--------FGWRAAFLILAILSLLAAVLLLLPRPPP------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 232 DKLEQGDRQGLQEGPKISFKEIATKHWRSLLACIglvIATNVTYYMLLTYMPSYLSHnLHYSEDHGVLIIIAIMIGMLFV 311
Cdd:pfam07690 176 ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLAL---LLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIG 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 312 QPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAA 391
Cdd:pfam07690 252 RLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGL 331
|
330
....*....|...
gi 749612430 392 AFNISVLVAGLTP 404
Cdd:pfam07690 332 YNTAGSLGGALGP 344
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
24-413 |
8.67e-24 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 104.39 E-value: 8.67e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 24 RKAITAASLGNAMEWFDFGVYGFVAYALGKVFfpgadpSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:PRK03893 19 WKAFSAAWLGYLLDGFDFVLITLVLTEVQGEF------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 104 VIMSISTFCIGLIPSYASigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAGVV 183
Cdd:PRK03893 93 VLFSVGTLACGFAPGYWT--------LFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFL----ISGFSIGAVVA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 184 VLISTVVGEdnflEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQH----------VDKLEQGDRQGLQEGPK------ 247
Cdd:PRK03893 161 AQVYSLVVP----VWGWRALFFIGILPIIFALWLRKNLPEAEDWKEKhagkapvrtmVDILYRGEHRIINILLTlaaaaa 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 248 --------------------------ISF-KEIATKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLI 300
Cdd:PRK03893 237 lwfcfagnlqnaaivavlgllcaaifISFmVQSSGKRWPTGVMLMVVVLFAFLYSWPIQALLPTYLKTDLGYDPHTVANV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 301 IIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFILINSNV--IGLIFAGLLMLAvilNCFTGVMASTLPA 378
Cdd:PRK03893 317 LFFSGFGAAVGCCVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAIGGANVwvLGLLLFFQQMLG---QGISGLLPKLIGG 393
|
410 420 430
....*....|....*....|....*....|....*
gi 749612430 379 MFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVES 413
Cdd:PRK03893 394 YFDTEQRAAGLGFTYNVGALGGALAPILGALIAQR 428
|
|
| Osmo_CC |
pfam08946 |
Osmosensory transporter coiled coil; The osmosensory transporter coiled coil is a C-terminal ... |
454-498 |
1.00e-23 |
|
Osmosensory transporter coiled coil; The osmosensory transporter coiled coil is a C-terminal domain found in various bacterial osmoprotective transporters, such as ProP, Proline/betaine transporter, Proline permease 2 and the citrate proton symporters. It adopts an antiparallel coiled-coil structure, and is essential for osmosensory and osmoprotectant transporter function.
Pssm-ID: 430338 Cd Length: 45 Bit Score: 93.60 E-value: 1.00e-23
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 749612430 454 SDIQEAKEILGEHYDNIEQKIEDIDQEIAELQVKRTRLVQQHPRI 498
Cdd:pfam08946 1 SDRQEAKELLQEHYDNIEQKIEDIDEEIAALEEKRQRLVDQHPHI 45
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
24-410 |
2.97e-22 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 98.85 E-value: 2.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 24 RKAITAASLGNAMEWFDFGVYGFVAYALGkvffpgADPSVQMVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 103
Cdd:PRK12307 17 KNALFSAWLGYVFDGFDFMLIFYIMYLIK------ADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 104 VIMSISTFCIGLIPSYasigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAGVV 183
Cdd:PRK12307 91 VAYSVGTGLSGLASGV--------IMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFL----VSGFGIGNIIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 184 VLISTVVGEdnflEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEQGDRQGLQEGPKISFKEIATKHWRSLLA 263
Cdd:PRK12307 159 AYFMPSFAE----AYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFNRAQFPLTL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 264 CIGLVI----ATNVTYYMLLtymPSYLSHNlhySEDHGVL--IIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFV 337
Cdd:PRK12307 235 CVFIVLfsifGANWPIFGLL---PTYLAGE---GFDTGVVsnLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFL 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 749612430 338 LAIPAFILI--NSNVIGLIFAGLLMLAVILncfTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWL 410
Cdd:PRK12307 309 FIFPLFRIPqdNYLLLGACLFGLMATNVGV---GGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWL 380
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-433 |
3.06e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 86.33 E-value: 3.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 30 ASLGNAMEWFDFGVYGFVAYALGKVFfpGADPSVQMVAalatFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSIS 109
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSF--GLSASQLGLL----FALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 110 TFCIGLIPSYasigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTv 189
Cdd:cd06174 75 ALLFAFAPSF--------WLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAS- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 190 vgednFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQhvdkleqgdRQGLQEGPKISFKEIATKHWRSLLACIGLVI 269
Cdd:cd06174 146 -----SLGFGWRAVFLIAAALALLAAILLLLVVPDPPESA---------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 270 --ATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFILIN 347
Cdd:cd06174 212 ifLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 348 SNVIGLIFAGLLMLAVILncFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSQNLMMPAYYLMVI 427
Cdd:cd06174 292 SLLLLLLLLLLLGFGLGG--LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVL 369
|
....*.
gi 749612430 428 AVVGLI 433
Cdd:cd06174 370 LLLAAI 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
81-433 |
4.29e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 85.68 E-value: 4.29e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17324 49 LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFA--------LLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 161 RGF-MGSWldfgsIAGFVLGAGVVVLISTVVGEdnflEWGWRIPFFLALPLGLIG-LYLRHALEETPAFQqhvdkleqgd 238
Cdd:cd17324 121 RGRaIGLV-----FSGLTLGLVLGRPLGGLLGQ----LLGWRAAFLAIAVLALLAaLLLWRLLPSLPPKK---------- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 239 rqglqEGPKISFKEIAtKHWRS--LLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMG 316
Cdd:cd17324 182 -----PGSLGLLSSLL-LLLRNprLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 317 LLSDRFGRRPfvIMGSIALFVLAIPAFILINSNVIGLIfaGLLMLAVILNCFTGVMASTLPAMFPTHIRysALAAAFNIS 396
Cdd:cd17324 256 RLADRGGRRA--LLIALLLLAAALLLLTLLGPSPLLLL--VGLVLWGLGFFAAHSALQTRVLRLAPEAR--GLASSLYLA 329
|
330 340 350
....*....|....*....|....*....|....*....
gi 749612430 397 VLVAGLT--PTLAAWLVEsSQNLMMPAYYLMVIAVVGLI 433
Cdd:cd17324 330 AYNLGGAlgAALGGLVLD-HGGWAGVGWVGAALLLLALL 367
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
87-438 |
6.03e-18 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 85.31 E-value: 6.03e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 87 GMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGS 166
Cdd:cd17319 59 GWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTS--------LYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATG 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 167 WLDFGSIAGFVLGAGVVVLISTVvgednfleWGWRIPFFLalpLGLIGLYLRhaleetpafqqhvdkleqgdrqglqegp 246
Cdd:cd17319 131 LFNSGAPLGAAIGPPLSGWLLLL--------FGWRWAFII---EGLLGLLLA---------------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 247 kisfkeIATKHW-RSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRF--G 323
Cdd:cd17319 172 ------VLWWFYlRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 324 RRPFVIMGSIALFVLAIPAFILINSNVIGLIFagLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLT 403
Cdd:cd17319 246 ARRLVIIIGLLLAAVGLLLAYLTTSPVVAVIL--LSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVA 323
|
330 340 350
....*....|....*....|....*....|....*
gi 749612430 404 PTLAAWLVESSQNLMMPAYYLMVIAVVGLITGVTM 438
Cdd:cd17319 324 PLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
77-414 |
2.17e-16 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 81.49 E-value: 2.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 77 LIRPLGGLFFGMLGDKYGRQK-ILAITIVIMSISTFCIGLIPSYASIG--IWAPILLLLCKMAqgfsvggeYTGASI--- 150
Cdd:COG2211 61 ITDPLIGALSDRTRTRWGRRRpWILIGAIPLALSFVLLFTAPDLSPTGklIYALVTYLLLGLA--------YTLVNIpys 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 151 -FVAEYSPDRK-RGFMGSWLDFGSIAGFVLGAGVVVLISTVVGEDNflEWGWRIPFFLALPLGLIGLYL-RHALEETPAf 227
Cdd:COG2211 133 aLGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA--ALGYRLTALIFAVLGLLAFLLtFFGTKERPV- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 228 qqhvdkleqgdrqglQEGPKISFKEI--ATKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIM 305
Cdd:COG2211 210 ---------------PEEEKVSLKESlkALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYF 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 306 IGMLFVQPIMGLLSDRFGRRPfVIMGSIALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFP---- 381
Cdd:COG2211 275 LAALLGAPLWPRLAKRFGKKK-AFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydew 353
|
330 340 350
....*....|....*....|....*....|....*.
gi 749612430 382 -THIRYSALAAAFN--ISVLVAGLTPTLAAWLVESS 414
Cdd:COG2211 354 kTGRRREGLYFGIFtfAIKLGQALAGALAGLLLALF 389
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
62-362 |
4.35e-16 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 79.52 E-value: 4.35e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 62 SVQMVAALATFS--VPFLIRPLgglfFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGF 139
Cdd:cd17478 29 SYAQAGLLVSVFsiTSSLLQPL----FGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW--------LLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 140 SVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIaGFVLGAGVVVLIstvvgednFLEWGWRIPFFLALPLGLIGLYLRH 219
Cdd:cd17478 97 GSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNL-GFALGPLIAAAL--------VALFGGLGLLILLIIPGLAVALLLL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 220 ALEETPAFQQHvdkleqgdrqglQEGPKISFKEIATKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLhYSEDHGVL 299
Cdd:cd17478 168 RLRPLKKPEAK------------KAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG-YSLVFAGL 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 749612430 300 IIIAIMIGMLFVQPIMGLLSDRFGRRpFVIMGSIALFVLAIPAFILINS--NVIGLIFAGLLMLA 362
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSDRFGRR-RVIIASLLLAAPFLLLFLLTPGiwSYILLVLAGFLLFA 298
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
66-438 |
1.01e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 78.76 E-value: 1.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 66 VAALATfSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEY 145
Cdd:COG2807 54 QAGLLT-TLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVA--------LLLAGTALIGAGIAVGN 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 146 TGASIFVAEYSPDRkRGFMGSWLDFGSIAGFVLGAGVVVLISTVvgednfleWGWRIPF-FLALPLGLIGLYLRHALEET 224
Cdd:COG2807 125 VLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAA--------LGWRGALaVWALLALLALLLWLPLLRRR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 225 PAFQQHvdkleqgdrqglqEGPKISFKEIatkhWRSLLA-CIGLVIAT-NVTYYMLLTYMPSYLsHNLHYSEDHGVLIII 302
Cdd:COG2807 196 PAAAAA-------------APAAASLRSL----WRSPLAwLLTLFFGLqSLLYYAVVAWLPPIL-RDAGLSAATAGLLLS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 303 AIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFILINSnviGLIFAGLLMLAVILNCFTGVMASTLPAMFPT 382
Cdd:COG2807 258 LFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPG---SLPWLWAVLLGLGQGGLFPLALTLIGLRART 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 749612430 383 HIRYSAL-AAAFNISVLVAGLTPTLAAWLVESSQNLMMPAYYLMVIAVVGLITGVTM 438
Cdd:COG2807 335 PAEAAALsGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
62-434 |
7.49e-15 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 76.09 E-value: 7.49e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 62 SVQMVAALatfsvpfLIRPLGGLffgmLGDKYGRQKILAITIVIMSISTFCIGLIPSyasigiwaPILLLLCKMAQGFSV 141
Cdd:cd17489 38 GLFTLAAL-------LARPFAGR----LLDRFGRKRLLLIGLLIFALATLLYLLATS--------VALLLVLRLIHGIGW 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 142 GGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTvvgednflEWGWRIPFFLALPLGLIGLYLrhal 221
Cdd:cd17489 99 GAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ--------HLGFAVLFIVAAVLALLALLL---- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 222 eetpAFQQHVDKLEQGDRQGLQEGPKISFKEIatkhwRSLLACIGLVIATnVTYYMLLTYMPSYLSHNLHyseDHGVLII 301
Cdd:cd17489 167 ----VFLVKDPPPVAAEEAEAGTRAFRRLVEK-----KVLPPALILFLAS-IAYGAISTFLPLYAAERGI---SNAGLFF 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 302 IAIMIGMLFVQPIMGLLSDRFGRRpFVIMGSIALFVLAIPAFILINSNVIGLIFAGL--LMLAVILNCFTGVMASTLPAm 379
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPK-TVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLygLGFGLLFPALQALAVDLVPP- 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 749612430 380 fptHIRYSALaAAFNISV-LVAGLTPTLAAWLVESSQNLMMPAYYLMVIAVVGLIT 434
Cdd:cd17489 312 ---HRRGAAN-GTFFIFFdLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
50-358 |
8.29e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 76.07 E-value: 8.29e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 50 ALGKVFFPGADPSVQMVaalatFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYasigiwapIL 129
Cdd:cd17473 24 AIAQHFVPNSELLVPLL-----LTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSL--------YA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 130 LLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMgswldFGSIAGFV-LGAGVVVLISTVVGednflEWGWRIPFFL-A 207
Cdd:cd17473 91 LLASRALLGIGVAGIMTLATALIGDYFEGEERAKM-----LGLQSAAMsLGGVVFLLLGGALA-----EIGWRAPFLVyL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 208 LPLGLIGLYLRhALEETpafqqhvdkleqgdRQGLQEGPKISFKEIATKHWRSLLACIGLVIATNVTYYMLLTYMPSYLS 287
Cdd:cd17473 161 LALPVLILVLL-FLPEP--------------ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQ 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 749612430 288 HNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRP-----FVIMGsIALFVLAIPAFILInsNVIGLIFAGL 358
Cdd:cd17473 226 ERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRllaigFALMA-LGFLLLALASGLWV--VLLGAILAGL 298
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
39-392 |
1.37e-14 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 75.39 E-value: 1.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 39 FDFGVYGFVAYALGKVFFPGADP----SVQMVAALATFSVPFlirplGGLFFGMLGDKYGRQKILAITIVIMSISTFCIG 114
Cdd:cd17364 13 YDLFSISLVTKILGRLYYGGKGSlpsgVSGLVNAAALVGTII-----GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 115 LIPSYASIGIWApiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFM----GSWLDFGSIAGfvlgaGVVVLISTVV 190
Cdd:cd17364 88 LSPGSTPLGVMG--WLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALiaavFAMQGFGILAG-----AIVTLILSAI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 191 GEDNF-------LEWGWRIPFFLALPLGLIGLYLRhaleetpafqqhvdkleqgdrqglqegpkisfkeiatkhwRSLLA 263
Cdd:cd17364 161 FEHPLpagtyhhADLVWRIVLGLGAIPALSVLYFR----------------------------------------KHLLG 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 264 CIGLVIATNVTYYMLLTYMPSYLSH------NLHYSEDHGVLIIIAIMIGMLFV--QPIMGLLSDRFGRRPFVIMG---- 331
Cdd:cd17364 201 TAGTWFLLDIAFYGQNLFQSTIISAigfsktMNAYQELFNIAVGQLIIALAGTVpgYWFTVFLIDRIGRKKIQMMGffgm 280
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 749612430 332 SIALFVLAIPAFILINSNVIGLIFAGLLMLAVIL--NCFTGVMAStlpAMFPTHIR--YSALAAA 392
Cdd:cd17364 281 TIFLLILAGPYDHWKISTIGFFVLYGLTFFFSNFgpNTTTFIVPA---EVFPARVRstCHGISAA 342
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
81-392 |
2.09e-14 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 74.91 E-value: 2.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASIGIWAPILlllckmaqGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIG--------GLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAGVVVLISTVVGEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFqqhvdkleqgdrq 240
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRW------------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 241 glqegpkisfkeIATKHWRSLLACIGL-----VIATNVTYYmlltYMPSYLShNLHYSEDHGVLIIIAI--------MIG 307
Cdd:cd17359 190 ------------LVSKGKPILIIGIGLaifqqFVGINVIFY----YGPEIFQ-NAGFSENAALLQTIGIgvvnviftIIA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 308 MLFVqpimgllsDRFGRRPFVIMGSI----ALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFT--GVMASTLPAMFP 381
Cdd:cd17359 253 ILLV--------DKVGRKPLLLIGSIgmaiSLLLIGTAFYFAPGSQASGIVALVLILLFVAFFAMSwgPVTWVLLSEIFP 324
|
330
....*....|.
gi 749612430 382 THIRYSALAAA 392
Cdd:cd17359 325 NRIRGLAMGIA 335
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
25-238 |
2.25e-14 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 75.15 E-value: 2.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 25 KAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQMVAALATFSVpFLIRPLGGLFFGMLGDKYGRQKILAITIV 104
Cdd:TIGR00887 16 RAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGPLPSSVSAAVNGSA-SIGTLAGQLFFGWLADKLGRKRVYGMELI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 105 IMSISTFCIGLIPSYASIGIWApiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRG-FMGSWLDFgsiAGF-VLGAGV 182
Cdd:TIGR00887 95 IMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGaMMAAVFAM---QGFgILAGAI 169
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 749612430 183 VVLISTVVGEDNF----------------LEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHV-DKLEQGD 238
Cdd:TIGR00887 170 VALIVLAGFKHSLeaaadeasctgscvpaVDYMWRILIGFGAVPALLALYFRLTIPETPRYTADVaKDVEQAA 242
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
84-421 |
2.70e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 74.13 E-value: 2.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyasigiwaPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKR-- 161
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS--------LAFLIAARALQGIGAAAIMPASLALIAATFPGERRgr 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 162 --GFMGSWLDFGSIAGFVLGAGVVVListvvgednfleWGWRIPFFLALPLGLIGLYLrhaleeTPAFqqhvdkleqgdr 239
Cdd:cd17321 121 alGLWGAVVGIGAALGPLLGGLLLEL------------FGWRWIFLINVPIGLVALLL------ARTF------------ 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 240 qglqegpkisfkeiatkhwrsLLACIGLVIaTNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLS 319
Cdd:cd17321 171 ---------------------SGAVLAAFL-LGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 320 DRFGRRPFVIMGSIALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSA---------LA 390
Cdd:cd17321 229 DRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAAsgilntarqLG 308
|
330 340 350
....*....|....*....|....*....|.
gi 749612430 391 AAFNISVLVAGLTPTLAAWLVESSQNLMMPA 421
Cdd:cd17321 309 GALGVALLGALLTAGLSANLGDSGVAALLSA 339
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
81-446 |
3.03e-13 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 71.97 E-value: 3.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASIGIWapillllcKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF--------RLLVGMGIGGIWVQAVVLNTEFLPKKQ 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAGVVVLIStvvgednflewGWR-------IPFFLALPLGLI------GLYLRHALEETPAF 227
Cdd:TIGR00898 214 RAIVGTLIQVFFSLGLVLLPLVAYFIP-----------DWRwlqlavsLPTFLFFLLSWFvpesprWLISQGRIEEALKI 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 228 QQHV----------DKLEQGDRQGLQEGPKI-SFKEIATKHW--RSLLACIGLVIATNVTYYMLLTYMPsylshNLHYSe 294
Cdd:TIGR00898 283 LQRIakingkklpaEVLSLSLEKDLSSSKKQySFLDLFRTPNlrKTTLCLMMLWFTTAFSYYGLVLDLG-----NLGGN- 356
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 295 dhgVLIIIAIMIGMLFVQPIMGLLS-DRFGRRPfVIMGSIALFVLAIPAFILINSN----VIGLIFAGLLMLAVILNCft 369
Cdd:TIGR00898 357 ---IYLDLFISGLVELPAKLITLLLiDRLGRRY-TMAASLLLAGVALLLLLFVPVDlyflRTALAVLGKFGITSAFQM-- 430
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749612430 370 gVMASTlPAMFPTHIRYSALAAAFNISVLVAGLTPtLAAWLVESsqNLMMPAYYLMVIAVVGLITGVTMKETANQPL 446
Cdd:TIGR00898 431 -VYLYT-AELYPTVVRNLGVGVCSTMARVGSIISP-FLVYLGEK--WLFLPLVLFGGLALLAGILTLFLPETKGVPL 502
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
34-431 |
3.19e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 70.69 E-value: 3.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 34 NAMEWFDFGVYGFVAYALGKVF-FPGADPSVQMVAALATFSVpflirplGGLFFGMLGDKYGRQKILAITIVIMSISTFC 112
Cdd:cd17365 8 IVLDGFDLAVMGFVAPALAQDWgLSPAQLGPVGSAALFGMAI-------GALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 113 IGLIPSYASIGIWapillllcKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAGVVVLISTVVGE 192
Cdd:cd17365 81 TAFAQSVLQLALL--------RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLM----FCGYPLGAALGGFLAAALIP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 193 dnflEWGWRIPFFLALPLGLIGLYLrhaleetpafqqhvdkleqgdrqglqegpkisfkeiatkhWRSLLACIGLVIATN 272
Cdd:cd17365 149 ----AFGWRSVFLLGGVPPLILLPL----------------------------------------LRGTLLLWVTFFMGL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 273 VTYYMLLTYMPSYLSHNlHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRpFVIMGSIALFVLAIPAFILINSNVIG 352
Cdd:cd17365 185 LLVYLLNSWLPKLMVEA-GYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPK-RVLALFFALGAVSLALLGVSPASLVL 262
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749612430 353 LIFAGLLMLAVILNCFTGVMASTlPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSQNLMMPAYYLMVIAVVG 431
Cdd:cd17365 263 LYVLVFLAGACVNGAQVGLYALA-ARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALG 340
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
82-447 |
5.67e-13 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 70.83 E-value: 5.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 82 GGLFFGMLGDKYGRQKILAITIVImsistFCIGLIPSYASIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKR 161
Cdd:TIGR00879 87 GALFAGWLSDRFGRKKSLLIIALL-----FVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALR 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 162 GFMGS----WLDFGSIAGFVLGAGVVVLISTVvgednflewGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEQG 237
Cdd:TIGR00879 162 GALTSlyqlAITFGILVAYGFGSGKVSLNNTL---------GWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEA 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 238 -------------DRQGLQEGPKISFKEIATKH-----WRSLLAC-----------IGLVIATNVTYYMLLTYMPSYLSH 288
Cdd:TIGR00879 233 rkslarlrgtsgeDKELLDELELIDIKRSIEKRsvqpsWGSLFSStrrirrrlflgVVLQWFQQFTGINAIMYYSPTIFE 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 289 NLHYSEDHGVLIIIAIMIgMLFVQPIMGL-LSDRFGRRPFVIMG----SIALFVLAIPAFILIN--SNVIGLIFAGLLML 361
Cdd:TIGR00879 313 NAGVSTDHAFLVSIIVGA-VNFAFTFVAIfLVDRFGRRPLLLIGaagmAICLFVLGILGASFVTgsSKSSGNVAIVFILL 391
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 362 AVILNCFT-GVMASTLPA-MFPTHIRYSALAAAFN----ISVLVAGLTPTLaawlvessQNLMMPAYYLMVIAVVGLITG 435
Cdd:TIGR00879 392 FIAFFAMGwGPVPWVIVSeIFPLSLRPKGISIAVAanwlANFIVGFLFPTM--------LESIGVGGVFIFFGGLNVLGL 463
|
410
....*....|....*.
gi 749612430 436 VTMK----ETANQPLK 447
Cdd:TIGR00879 464 IFVYfflpETKGRTLE 479
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
58-439 |
1.43e-12 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 69.14 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 58 GADPSvqMVAALAT-FSVPFLIRplgGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMA 136
Cdd:cd17474 30 GASPA--QVGLLITaFTLPAAVL---MPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFA--------LLLAGRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 137 QGFSVGGEYTGASIFVAEYSPDRKR----GFMGSWLDFGSIAGFVLGAGVVvlistvvgednflEWGWRIPFFLALPLGL 212
Cdd:cd17474 97 QGIGAAGLGPLALTLIGDLFEGGERakamGLYEAALGLGIAVGPLLGGLLA-------------AISWRYPFFLLAALIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 213 IG-LYLRHALEETPAFQQHVDKLEQGDrqglqegpkisfkEIATKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLH 291
Cdd:cd17474 164 VAfLAILFLLPEPKEKAKSSSATKLRD-------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 292 YSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFILINSNVIglifagLLMLAVILNCFTGV 371
Cdd:cd17474 231 ISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLAL------LLIAIVLFGLGLGL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 749612430 372 MASTLPAM----FPTHIRYSALAA---AFNISVLVAgltPTLAAWLVEssqNLMMPAYYLMVIAVVGLITGVTMK 439
Cdd:cd17474 305 NLPLLTTLvtelAPEEERGTASSLynfVRFLGQAVG---PLLFGLLLE---IFGLSAPFLVGAAIALAAAVLLAL 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
64-433 |
3.49e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.96 E-value: 3.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 64 QMVAALATFSVPFLIrplGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYasigiwapILLLLCKMAQGFSVGG 143
Cdd:COG0738 44 QAGLLLFAFFLGYLL---ASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--------PLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 144 EYTGASIFVAEYSPDRKRGFMgSWLDFGSIAGFVLGAGVVVLISTvvgedNFLEWGWRIPFFL--ALPLGLIGLYLRHAL 221
Cdd:COG0738 113 LDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLIL-----LGLSLSWHLPYLIlaVLLLLLALLFLRSKL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 222 EETPAfqqhvdklEQGDRQGLQEGPKISFKEiatkhwRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLII 301
Cdd:COG0738 187 PEIEE--------EEEEAAGSAASLKSLLKN------PRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 302 IAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLaipafilinsnVIGLIFAGLLMLAVILNCFTGVMASTL-PAMF 380
Cdd:COG0738 253 SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVG-----------LLLALLAPGPWLALIGLALVGLGLSLMfPTIF 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 749612430 381 PTHIRYSALAAAFNISVLVA------GLTPTLAAWLVESSQnlMMPAYYLMVIAVVGLI 433
Cdd:COG0738 322 SLALDGLGKRTAAAVSAVLImgivggAIGPPLIGFLADAFG--LRAAFLVPLVCYLLIL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
258-412 |
1.28e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.77 E-value: 1.28e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 258 WRSLLACIGLVIATNVTYYMLLTYMPsYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPfVIMGSIALFV 337
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRR-VLLLGLLLFA 86
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 749612430 338 LAIPAFILINSnvIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVE 412
Cdd:COG2814 87 LGSLLCALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
81-438 |
2.43e-11 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 65.27 E-value: 2.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyasigiwaPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17477 46 LGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDS--------PWVWFLLRFVMGIGLAGLFVVSESWLNALATNEN 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAGVVVLISTVvgednflewGWRIPF----FLALPLGLIGLYLRHALEETPAfqqhvdkleq 236
Cdd:cd17477 118 RGRVLGLYSTVLGLGFALGPLLLALVGTA---------GALPFLiaavLLLLALVPLLLTRRAAPEIEEA---------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 237 gdrqglqegPKISFKEIATKHWRSLLACI--GLVIATnvtyymLLTYMPSYLSHnLHYSEDHGVLIIIAIMIGMLFVQPI 314
Cdd:cd17477 179 ---------ESISLRRLLRIAPLALLGAFvaGFLEGA------FYSLLPLYGLR-LGLSVAQAALLLAAFVLGGLLLQWP 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 315 MGLLSDRFGRRpFVIMGSIALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTgvMASTLPAMFPTHIRYSALAAAFN 394
Cdd:cd17477 243 LGWLADRFDRR-RVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYT--LALALAGDRLPGDELVAANAALL 319
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 749612430 395 ISVLVAGLT-PTLAAWLVEssqnLMMPAYYLMVIAVVGLITGVTM 438
Cdd:cd17477 320 LLYGLGSVIgPLLAGALMD----AFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
58-390 |
9.46e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.41 E-value: 9.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 58 GADPSVQMVAALAtFSVPFLIrplGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQ 137
Cdd:cd17328 30 LIDDSLAGLLQTV-FIISYMV---LSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFW--------QLLLFRALV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 138 GFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDF----GSIAGFVLGAgvvvLISTVVGednflewGWRIPFFLALPLGLI 213
Cdd:cd17328 98 GIGEASYSPIAPTIIADLFPKEKRTRALGVFYFaiplGSGLGYVVGG----LVAQATG-------GWRWAFRVTGVLGVL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 214 -GLYLRHALEETPAFQQHVDKLEQGDRQGLQEGPKISFKEIAtkHWRSLLACIGLVIATN-VTYYMLLTYMPSYLSHNLH 291
Cdd:cd17328 167 lAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPS--FILSTLGFTAVSFVTGaLAFWAPTFFLRAFGVGDLS 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 292 YSEDHGVLIIIAIMIGMLFVqPIMGLLSDRFGRRP---FVIMGSIALFVLAIPAFILINSNVIGLIFA-GLLMLAVILNC 367
Cdd:cd17328 245 SADVGLIFGAITCIAGVLGV-LLGGILADRLRRKTpraDPLVCAVGLLAAAPFLFLALVLALSNLLLAwVLLFLGEFLLS 323
|
330 340
....*....|....*....|....*
gi 749612430 368 FTG--VMASTLPAMFPTHiRYSALA 390
Cdd:cd17328 324 LNWapVFAILLYVVIPTR-RSTASA 347
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
81-392 |
2.17e-10 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 62.37 E-value: 2.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYP--------VLLVGRLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAGVVVLISTVVgednfleWGWRIPFFLALPLGLI---GLYLrhaLEETPAFQQhvdkleqg 237
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVSGYAFADVV-------GGWRYMYGLAAPPALLlgiGMWF---LPPSPRWQG-------- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 238 drqglqegpkisfkeiatKHWRSLLACIGLVIATNVT-YYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMG 316
Cdd:cd17362 188 ------------------NYRKPLIIGLGLVLFQQITgQPSVLYYAATIFKSAGFSAASDATLVSVGLGVFKLLMTIVAV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 317 LLSDRFGRRPFVIMGS----IALFVLAIpAFILINSNVIGLIFAGLLMLAVILNCF-------TGVMASTLpamFPTHIR 385
Cdd:cd17362 250 LLVDKLGRRPLLLGGVsgmvVSLFLLAA-YNLFVQMGPAGLAWLSLVALLLYVGAYqisfgpiSWLMVSEI---FPLRVR 325
|
....*..
gi 749612430 386 YSALAAA 392
Cdd:cd17362 326 GRAIALA 332
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
67-436 |
2.70e-10 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.86 E-value: 2.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 67 AALATFSVPFLirpLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASIGIWAPILLLLCKMAQG-FSVGGEY 145
Cdd:cd06173 38 LVLAAFFLPFL---LFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASaFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 146 TGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLIStvvgednfLEWGWRIPFFLALPLGLIGLYLRHALEETP 225
Cdd:cd06173 115 ALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG--------PGGAFAINALSFLLSALLLLFIRRPPPAAP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 226 AfqQHVDKLEQGDRQGLQEgpkisfkeiaTKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIM 305
Cdd:cd06173 187 G--ESSSLLLRDLREGLRY----------LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 306 IGMLFVQPIMGLLSDRFGRRPFVImgsIALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIR 385
Cdd:cd06173 255 VGALLGALLLGRLSKRRRRGRLLL---IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELR 331
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 749612430 386 YSALAAAFNISVLVAGLTPTLAAWLVEssqnlMMPAYYLMVIAVVGLITGV 436
Cdd:cd06173 332 GRVFSVYNALNSGAMPLGALLAGLLAD-----ALGLSAVFLLAGALLLLAA 377
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
73-436 |
3.53e-10 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 61.82 E-value: 3.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIglipsYASIGIWapiLLLLCKMAQGFSVGGEYTGASIFV 152
Cdd:cd17358 48 SLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLI-----AFAKDVW---MLYLGRFLAGFGGGAASVVVPVYI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 153 AEYSPDRKRGFMGS----WLDFGSIAGFVLGagvvvlistvvgedNFLEWGWrIPFFLALPLGL--IGLY---------- 216
Cdd:cd17358 120 AEIAPKNVRGALGSlnqlLVNIGILLGYVLG--------------SFLPWRT-LALIGAIPPVVflILLFfipesprwla 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 217 -------LRHAL-----------EETPAFQQHVDKLEQgdrqglqEGPKISFKEIATKHW-RSLLACIGLVI------AT 271
Cdd:cd17358 185 kkgreeeAEKSLqflrgkdadisKEAAEIQEELAELEK-------EAKESSFSDLFQRKYlKPLVIGLGLMLfqqlsgIN 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 272 NVTYYMlltympSYLSHNLH--YSEDHGVLIIIAIMIGMLFvqpIMGLLSDRFGRRPFVI--MGSIALFVLAIPAFILIN 347
Cdd:cd17358 258 AVIFYA------SSIFDEAGsgLDPNTATIIIGVVQVVGTL---VATLLVDRLGRRPLLLvsAIGMGIGLLALGLYFYLQ 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 348 SNVIGL----IFAGLLMLAVILNCFTGVMAstLPA-----MFPTHIRYSALAaafnisvlVAGLTPTLAAWLVESSQNLM 418
Cdd:cd17358 329 EHGALLssvsWLPLVGLVIYIISFSIGLGP--LPWvimseIFPAKIKGLAGS--------LVTLVNWLFAFIVTKTFPFL 398
|
410 420
....*....|....*....|..
gi 749612430 419 M----PAYYLMVIAVVGLITGV 436
Cdd:cd17358 399 TlawgASGTFWIFAGICGLALV 420
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
58-439 |
3.76e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 61.44 E-value: 3.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 58 GADPS-VQMVaaLATFSVPFLIrplGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMA 136
Cdd:cd17320 30 GASASaVQLT--LSAYLLGFAL---GQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIE--------QLLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 137 QGFSVGGEYTGASIFVAEYSPDRKR----GFMGSWLDFGSIAGFVLGAgvvvLISTVvgednfleWGWRIPF-FLALPLG 211
Cdd:cd17320 97 QGLGAAAGSVVARAIVRDLYSGAELakifSLLMMILAIAPALAPLLGG----LLLLF--------FGWRAIFvFLALLGL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 212 LIGLYLRHALEETpafqqhvdkLEQGDRQGLQEGPKISFKEIATKhwRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLH 291
Cdd:cd17320 165 LLLLLVLLFLPET---------LPEEKRKPLLSSLLRAYKRVLKN--RRFLGYALALGLSFAGLFAYLAAAPFIYIEQLG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 292 YSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFILINSNVIGLI-FAGLLMLAVILNCFTG 370
Cdd:cd17320 234 LSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWpLVAPLFLIFFGFGLIF 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 749612430 371 VMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSQNLMmpayyLMVIAVVGLITGVTMK 439
Cdd:cd17320 314 PNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPM-----GLLILVLGLLALLLLI 377
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
87-434 |
9.46e-10 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 60.28 E-value: 9.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 87 GMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGS 166
Cdd:cd17503 52 GWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--------LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 167 WLDFGSIAGFVLG---AGVVVlistvvgeDNFlewGWRIPFFLALPLGLIGLYLrhaleetpafqqhvdkleqgdrqglq 243
Cdd:cd17503 124 LVGLVILLAPAIGptlGGWLT--------DNL---SWRWIFYINLPIGILALLL-------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 244 eGPKISFKEIATkhwRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFG 323
Cdd:cd17503 167 -APLLDLRLFKD---RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 324 RRPFVIMGSIALFVLAIP-AFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHI-RYSA-------LAAAFN 394
Cdd:cd17503 243 PRLLLLAGLLLLALGTLLlAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIgDATAlfntirqLGGSIG 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 749612430 395 ISVLVAGLT----------PTLAAWLVESSQNLMMPAYYLMVIAVVGLIT 434
Cdd:cd17503 323 TALLATLLTnrtqfhhsrlSELLAQQVQKQALIIAFNDAFLVSAILLLVG 372
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
68-432 |
1.79e-09 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 59.47 E-value: 1.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 68 ALATfSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVImsisTFCIGLIPSYASIGIWapILLLLCKMaqGFSVGGEYTG 147
Cdd:cd17372 37 ALIT-SVVFAGMMIGSYLWGIVSDKYGRRKGLIISALW----TFYAGFLSAFAPNYMW--LIILRCLV--GLGLGGGPQL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 148 ASIFvAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTVVGednfleWGWRIpFFLALPLGLIGLYLRHALEETPAF 227
Cdd:cd17372 108 ASWY-LEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG------WRWLL-AFSSVPSSLLLVFYRWTPKTTLLL 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 228 QqhvdkleqgdrqglqegpkISFKEIATKHWRSLLACIGLVIATNVTYYMLLT-YMPSYLSHNLHYSEDHGVLIIIAIMI 306
Cdd:cd17372 180 W-------------------VIWFGNAFAYYGVVLLTTELNNSHNVCGSKSDSdSGESPTEKQCRNSNDVDYRDVFIATF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 307 GMLFVQPIMGLLSDRFGRRP--FVIMGSIALFVLaiPAFILINSNV-IGLIFAGllmLAVILNCFTGVMASTlPAMFPTH 383
Cdd:cd17372 241 AEFPGLLISAAMIDRLGRKAsmASMLFTCCIFLL--LLLICQSPFIlTVLLFGG---RACISAAFTVVYIYT-PEVYPTA 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 749612430 384 IRYSALAAAFNISVLVAGLTPTLAAWLVESSQNLMMpAYYLMVIAVVGL 432
Cdd:cd17372 315 VRALGVGTGSSVGRIGAILCPFIAQVLVHGSQTIAL-LLFSVVCLVSAI 362
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
81-436 |
1.91e-09 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 59.13 E-value: 1.91e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17317 40 IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYE--------LFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAGVVVLISTvvgednflewgWR-IPFFLALPLGLIGLYLRHaleeTPafqqhvdkleqgdr 239
Cdd:cd17317 112 RSFVGILFGLFWALGYMLLALLAYLIRD-----------WRwLQLAISLPGLLFLLLLWW----LP-------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 240 qglqegpkisfkeiatkhwRSLLACIGLVIATNVTYYMLLTYMPSyLSHNLH----YSedhGVLIIIAIMIGMLFVqpim 315
Cdd:cd17317 163 -------------------RRTIIVGLIWFVTSLVYYGLSLNSSN-LGGNLYlnffLS---GLVEIPAYFLALLLL---- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 316 gllsDRFGRRPfvimgsIALFVLAIPAFILInsnVIGLIFAGLLMLAVILNCFTGVMASTLPAM--------FPTHIRYS 387
Cdd:cd17317 216 ----DRLGRRW------TLSGSLLLAGLACL---VTALLPDDENTLALTLALVGKFAISAAFSViylytaelYPTVVRNT 282
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 749612430 388 ALAAAFNISVLVAGLTPTLAAWlveSSQNLMMPayyLMVIAVVGLITGV 436
Cdd:cd17317 283 GVGLCSTVARVGAILAPFIVLL---GKIGPLLP---LIIFGVLALLGGL 325
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
275-436 |
3.17e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.58 E-value: 3.17e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 275 YYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGsiaLFVLAIPAFILINSNVIGLI 354
Cdd:pfam07690 12 RSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIG---LLLFALGLLLLLFASSLWLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 355 FAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSQnlmmPAYYLMVIAVVGLIT 434
Cdd:pfam07690 89 LVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG----WRAAFLILAILSLLA 164
|
..
gi 749612430 435 GV 436
Cdd:pfam07690 165 AV 166
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
29-393 |
5.44e-09 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 57.97 E-value: 5.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 29 AASLGNAMEWFDFGVYGFVAYALGKVFFPGADPSVQ--MVAALATFSVpflirpLGGLFFGMLGDKYGRQKILAITIVIM 106
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQglVVSSLLLGAA------IGSLFGGPLADRFGRRKSLLIAAVLY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 107 SISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGS----WLDFGSIAGFVLGAGV 182
Cdd:cd17315 75 VIGALLSALAPNVW--------VLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTlnqlMITFGILLAYLLGLAL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 183 VVLIStvvgednfleWGWRIPFFLALPLGLIGLYLRHALEETPAfqqhvdkleqgdrqglqegpkisfkeiatkhwrsLL 262
Cdd:cd17315 147 SLSPP----------GWWRLMFALAAVPALLQLLLMFFLPESRA----------------------------------LL 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 263 ACIGLVIAT-----NVTYYmlltYMPSYLShNLHySEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMG----SI 333
Cdd:cd17315 183 VGVGLQLLQqltgiNAVMY----YAPTIFK-SAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGfagmAA 256
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 749612430 334 ALFVLAIPAFILINSNVIGLI-FAGLLMLAVILNCFTGVMASTL-PAMFPTHIRYSALAAAF 393
Cdd:cd17315 257 SLLLLAIAFLLPALAKAAGWLaLLGILLYIAAFAMGAGPVPWLLlSEIFPLRIRGKGMAIAT 318
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
81-359 |
5.51e-09 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 58.02 E-value: 5.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSY-ASIGIWApILLLLCKMAQGFSVGGEYtgasIFVAEYSPDR 159
Cdd:cd17345 53 LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSAtSSVGLMF-ILLFLNGWFQGMGWPPSG----RTMVHWFSKK 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 160 KRGFMGSWLDFGSIAGFVLGAGVVVLISTVVGEDNFLeWGWRIPFFLALPLGLIGLYLRHALEET---PAFQQHVDKlEQ 236
Cdd:cd17345 128 ERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWR-GAFIFPAIIAIIVAVIVLFLGKDTPESeglPPIEEYKGD-YP 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 237 GDRQGLQEGPKISFKEIATKH-------WrsllacigLVIATNVTYYML----LTYMPSYLSHNLHYSEDHGVLII---- 301
Cdd:cd17345 206 EEADGEEEEQELSAWEIFVKYvlknkllW--------YIAIANVFVYLVrygiLDWAPTYLSEVKGFSKAQAMWAFslfe 277
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 302 IAIMIGMLfvqpIMGLLSDRF--GRRPFVIMGSIALFVLAIPAFILINSNVIGLIFAGLL 359
Cdd:cd17345 278 WAAIPGTL----LAGWLSDKLfkGRRAPTGIIFMILVIVALIVYWLAPNVLVDLIALIAL 333
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
82-431 |
8.22e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 57.66 E-value: 8.22e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 82 GGLFFGMLGDKYGRQKILAITIV---IMSISTfciGLIPSYASigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPD 158
Cdd:PRK11551 66 GALLGGRLADRIGRKRILIVSVAlfgLFSLAT---AQAWDFPS--------LLVARLLTGVGLGGALPNLIALTSEAVGP 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 159 RKRGFMGSWLdfgsIAGFVLGAGVVVLISTVVGEDNflewGWRIPFFL--ALPLGLIGLYLRHaLEETPAFQQhvdkleq 236
Cdd:PRK11551 135 RLRGTAVSLM----YCGVPFGGALASVIGVLAAGDA----AWRHIFYVggVGPLLLVPLLMRW-LPESRAFAQ------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 237 gdrQGLQEGPKISFKEIATKHWRSlLACIGLVIA---TNVTYYMLLTYMPSYLSHNlHYSEDHGVLIIIAIMIGMLFVQP 313
Cdd:PRK11551 199 ---AAGAGKQRAPVLRALFGEGRA-TATLLLWISyffTLIVLYFLLNWLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGSL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 314 IMGLLSDRFGRRPFV--IMGSIALFVLAIPAFILINSNVIGLIFAGLLMLAVilncfTGVMASTLPAMFPTHIRYSALAA 391
Cdd:PRK11551 274 LIGALMDRLRPRRVVllIYAGILASLAALAAAPSFAGMLLAGFAAGLFVVGG-----QSVLYALAPLFYPTQVRGTGVGA 348
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 749612430 392 AFNISVLVAGLTPTLAAWLV---ESSQNLMMPAYYLMVIAVVG 431
Cdd:PRK11551 349 AVAVGRLGSMAGPLLAGQLLalgRSTVGVIGASIPVILVAALA 391
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
72-433 |
1.57e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 56.51 E-value: 1.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 72 FSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASigiwapiLLLLCKMAQGFSVGGEYTGASIF 151
Cdd:cd17355 44 FTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQ-------LYLLWGLLGGGGAGTLAAVAFAT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 152 VAEYSPDRKRGF-MGSWLDFGSIAGFVLGAGVVVLISTvvgednfleWGWRIPF----FLALPLGLIGLYLRHALEETPA 226
Cdd:cd17355 117 VAAWWFERRRGLaLGILTAGGGLGSLVFLPLGAALIEA---------FGWRTALlvlaLLALLVLVPVLLLLRRRPADLA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 227 FQQHVDKLEQGDRQGLQEgpkisfkeiATKHWRSLLACIGLVIaTNVTYYMLLTYMPSYLSHnLHYSEDHGVLIIIAIMI 306
Cdd:cd17355 188 LRAYDDASPASPGSTLKE---------ALRSASFWLLALAFFL-CGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 307 GMLFVQPIMGLLSDRFGRRPFVImGSIALFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTH--I 384
Cdd:cd17355 257 FNIVGRLLSGWLGDRYSPRRLLA-ASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSygT 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 749612430 385 RYSALAAAFnisVLVAGLTPTLAAWLVESSQNLMMPAYYLMVIAVVGLI 433
Cdd:cd17355 336 LFGLVFAPH---QLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
255-459 |
1.75e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.43 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 255 TKHWRsLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDH-GVLIIIAIMIGMLFvQPIMGLLSDRFGRRpfvIMGSI 333
Cdd:COG2223 1 SGRWR-VLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQlGLLFAIPVLVGALL-RIPLGFLVDRFGPR---RVLLI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 334 ALFVLAIPAFIL-INSNVIGLIFAGLLMLAVILNCFTGVMAsTLPAMFPTHIRYSAL---AAAFNISVLVAGLtptLAAW 409
Cdd:COG2223 76 GLLLLGIGLLLLaLAVSYWLLLLLGLLLGIGGGGSFAVGIA-LVSKWFPPDRRGLALglaAGGGNLGAAVAAF---LAPL 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 749612430 410 LVESSQNLMMPAYYLMVIAVVGLITGVTMKETANQPLKGATPAASDIQEA 459
Cdd:COG2223 152 LIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEA 201
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
81-433 |
2.68e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 55.71 E-value: 2.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASIGiwaPILLLLckmaqGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLL---VLLFLV-----GAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAGVVVLIstvvgednFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEQGDRQ 240
Cdd:cd17475 118 RGLAMGIRQTGVPLGGALAAALLPPL--------ALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 241 GLQEgpKISFKEIatkhWRSLLACIGLVIATnvtyYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSD 320
Cdd:cd17475 190 SLKE--VLRNRDV----WLIAIAGALLVAPQ----FALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSD 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 321 RF--GRRPFVIMGSIALFVLAIPAFILI-NSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISV 397
Cdd:cd17475 260 RVfgGRRRPVLVITAAIAAAALLVLSLLsPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINF 339
|
330 340 350
....*....|....*....|....*....|....*.
gi 749612430 398 LVAGLTPTLAAWLVESSQNLMMPAYYLMVIAVVGLI 433
Cdd:cd17475 340 IGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAAL 375
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
274-441 |
1.22e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 53.75 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 274 TYYMLLTYMPSYLsHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGsiaLFVLAIPAFILINSNVIGL 353
Cdd:cd17489 11 SFYLLLPVLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIG---LLIFALATLLYLLATSVAL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 354 IFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVeSSQNLMMPAYYLMVIAVVGLI 433
Cdd:cd17489 87 LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLY-QHLGFAVLFIVAAVLALLALL 165
|
....*...
gi 749612430 434 TGVTMKET 441
Cdd:cd17489 166 LVFLVKDP 173
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
62-364 |
2.12e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 53.03 E-value: 2.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 62 SVQMVAALATFSVPFLIrplGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLipsyaSIGIWAPILLLLCKMAQGFSV 141
Cdd:cd17357 48 DLLWSLIVSIFFIGGAI---GSFISAFLANRFGRKNGLLISNALLVVSSLLMFL-----SKSAKSPELLIFGRFLVGIAC 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 142 GGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAgvvvlistVVGEDNFL--EWGWRIPFFLALPLGLIGLYLRH 219
Cdd:cd17357 120 GLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQ--------VFGLPSVLgtETLWPYLLFFPGIPALLQLAALP 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 220 ALEETPAF-------------------------QQHVDKLEQGDRQGLQEGpKISFKEIATK---HWRSLLACIglviat 271
Cdd:cd17357 192 FFPESPKFlliskgdeeeaekslkflrgieddvDQELEEIKKESEQMGDQK-QVSLMQLLRDpslRLPLLLVLV------ 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 272 nVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIM--IGMLFVQPIMGLLS----DRFGRRPFVIMG----SIALFVLAIP 341
Cdd:cd17357 265 -VSASQQFSGINAIFFYSTFIFENAGFSPQLAEWanLGIGIVNVLSTIVGpfliEKVGRRPLLLISlsvcAVALLLMSVF 343
|
330 340
....*....|....*....|...
gi 749612430 342 AFILINSNVIGLIFAGLLMLAVI 364
Cdd:cd17357 344 LFLSEQNSWMSYGCIVAIFLFIF 366
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
84-362 |
2.53e-07 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 52.57 E-value: 2.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 84 LFFGMLGDKYGRQKILaitivIMSISTFCIGLIPSYASIGIWApilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKR-- 161
Cdd:cd17502 48 PIYGKLSDLFGRKWVL-----LIAIVIFELGSLLCGLAPNMTM---LIVGRAIQGIGGGGLMSLAFIIIADLVPPRERgk 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 162 --GFMGSWLDFGSIAGFVLGAGVVVLIStvvgednflewgWRIPFFLALPLGLIGLYLrhaleetpafqqhvdkleqgdr 239
Cdd:cd17502 120 yqGYIGAVFGIASVAGPLIGGAFTDHLS------------WRWCFYINLPIGGLALAL---------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 240 qglqegpkisfkeiatkhWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLS 319
Cdd:cd17502 166 ------------------LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALI 227
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 749612430 320 DRFGR-RPFVIMGSIaLFVLAIPAFILINSNVIGLIFAGLLMLA 362
Cdd:cd17502 228 SKTGRyKPLIVIGTI-LMSVGAGLLTTLTLDTSKWLLIGYLILL 270
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
62-341 |
5.46e-07 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 51.88 E-value: 5.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 62 SVQMVAALAtFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyasigIWApilLLLCKMAQGFsV 141
Cdd:cd17391 33 LVELWSGLA-FSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTN-----VWQ---LLILRLLQGV-F 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 142 GGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAgvvvLISTVVgEDNFlewGWRIPFFLALPL----GLIGLYL 217
Cdd:cd17391 103 SGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGP----LLGGFL-ADLF---GIRNVFFITGGLlflaFLLTLFF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 218 RHAleetpafqqhvdkleqgDRQGLQEGPKISFKEIatkhWRSLLA---CIGLVIATNVTY---YMLLTYMPSYLSHnLH 291
Cdd:cd17391 175 VKE-----------------DFKPVEKKKMVSTKEV----WNSVPNpslLISLFVTTFIIQlanQSIEPILTLYIRQ-LM 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 749612430 292 YSEDHGVLI---IIAIM-IGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIP 341
Cdd:cd17391 233 GDASNLAFIsglVFSATgVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIP 286
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
251-413 |
8.13e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 8.13e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 251 KEIATKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPfVIM 330
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRR-VLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 331 GSIALFVLAIPAFILINSnvIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWL 410
Cdd:COG2271 80 IGLLLWGLATLLFGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWL 157
|
...
gi 749612430 411 VES 413
Cdd:COG2271 158 LAA 160
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
81-225 |
2.07e-06 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 49.94 E-value: 2.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVImsistFCIGLIPSYASIGIWApiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17356 60 FGALISSFLSDRIGRKKSIQIGCVI-----YIIGAIIQVAAIGKWY--QLIVGRIIAGLGVGFASVLVPVYQSEVAPKHI 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAgvvvlISTVVGEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETP 225
Cdd:cd17356 133 RGTLVSLYQLAITIGILVAY-----CINYGTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESP 192
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
166-394 |
2.22e-06 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 49.91 E-value: 2.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 166 SWLDFGSIAGFVLGAGVVVLISTVVGEDNFlEWGWRIPFFLALPLGLIGLYLRH--ALEETPAFQQHVDKLeqgdrqglq 243
Cdd:cd17332 139 SWRMFFATIGGLLVTVLPPPLVAYFGGGNA-SRGYFLTALIIGIIGIILLLICFfgTRERVVPPEEEKSKL--------- 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 244 eGPKISFKEIatKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHySEDHGVLIIIAIMIGMLFVQPIMGLLSDRFG 323
Cdd:cd17332 209 -PLLKSLKAL--LKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLG-GRAELVLLLLLILSGALLALLPWPPLKKRFG 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 324 RRPFVIMGsIALFVLAIPAFILINSNVIGLIFAgllmLAVILNCFTGVMASTLPAMFP---------THIRYSALAAAFN 394
Cdd:cd17332 285 KKKAFFIG-LLLAILGLLLLFFLPPGNLVLILV----LAVLAGIGYGGANLLPWAMLAdvidygelkTGKRREGIFYSVM 359
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
84-372 |
2.62e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 49.50 E-value: 2.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYasigiwapILLLLCKMAQGFSvGGEYTGASIFVAEYSPDRKRGF 163
Cdd:cd17504 49 PILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNL--------PVLIAGRALQGIG-GAVFPLAFALVREEFPPERVPV 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 164 MGSWLDfgsiAGFVLGAGVVVLISTVVGEDnfleWGWRIPFFLALPLGLIGLYLrhaleetpafqqhvdkleqgdrqglq 243
Cdd:cd17504 120 AQGILS----ATFGIGAGIGLPLGGWIVQH----LGWRWIFWTAAPVAVLLAAL-------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 244 eGPKISFKEIATKHWrsLLACIGLVIATnVTYYMLLTYMPSYLSHNLHYSEDHGV----LIIIAIMIGMLFVQPIMGLLS 319
Cdd:cd17504 166 -VPLIDLRLLRRRNV--LLANITALLAG-FGMFMVFQLLPQLLQLPTPTGFGLGIteagLLLLPGALVMLIAGPLAGRLI 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 749612430 320 DRFGRRPFVIMGSIaLFVLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGVM 372
Cdd:cd17504 242 ARVGPRRVLLIGLV-ISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLP 293
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
299-441 |
2.68e-06 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 46.87 E-value: 2.68e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 299 LIIIAIMIGMLFVQPIMGLLSDRFGRRPfVIMGSIALFVLAIPAFILINSnvIGLIFAGLLMLAVILNCFTGVMASTLPA 378
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSGLLTDRFGRKP-VLLVGLFIFVLSTAMFALSSN--ITVLIIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749612430 379 MFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSqNLMMPAYYLMVIAVVGLITGV-TMKET 441
Cdd:TIGR00880 79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFL-GWRAPFLFLAILALAAFILLAfLLPET 141
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
87-418 |
4.25e-06 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 48.77 E-value: 4.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 87 GMLGDKYGRQKILAITIVIMSISTFcigLIPSYASIGIWApilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGS 166
Cdd:cd17318 77 GYLAEKYGAKRVLGYSILITALLTL---LTPLAARGGYGA---LIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 167 wldfGSIAGFVLGAGVVVLISTVVGEdnflEWGWRIPFFLALPLGLIGLYLRHALeeTPAFqqhvdkleqgdrqglqegp 246
Cdd:cd17318 151 ----IAYSGSQFGTVIAMPLSGFLCE----SLGWPSIFYIFGGLGLLWCLLWFFL--VLPV------------------- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 247 kisfkeiatkhWRSLLACIGlviaTNVTYYMLLTYMPSYLSHNLHYS-EDHGVLIIIAiMIGMLFVQPIMGLLSDRFGRR 325
Cdd:cd17318 202 -----------WAIVVAHFG----HNWGFYTLLTELPTYMSDVLHFNiKSNGFLSSLP-YLAMWICSIVGGYLADWLRSR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 326 PFV-------IMGSIALFVLAIPAFIL--INSNVIGLIFagLLMLAVILN--CFTGVMASTLpAMFPthiRYSA--LAAA 392
Cdd:cd17318 266 GILstttvrkLFTSIGFLGPGVFLIALgyLGSNATLAVV--FLTLSVGLSgaCYSGFLVNHL-DLAP---NYAGtlMGIT 339
|
330 340
....*....|....*....|....*.
gi 749612430 393 FNISVLVAGLTPTLAAWLVESSQNLM 418
Cdd:cd17318 340 NTAATIAGIISPLIVGAIVKNDQTIG 365
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
45-393 |
4.84e-06 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 48.73 E-value: 4.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 45 GFVAYALGKVFFPGAdPSVQ------MVAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPS 118
Cdd:cd17323 8 TFVVTFGSSIYSPAL-PQIAedfhvsEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 119 YASigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRG-FMGSWldfgsIAGFVLGAGVVVLISTVVGEdnflE 197
Cdd:cd17323 87 IAM--------LIILRFLQGFFGSSPLAIGAGTIADLFTPEERGkAMGVY-----SLGPLLGPALGPIIGGFITQ----S 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 198 WGWRIPFFLALPLGLIGLYLrhaleetpafqqhvdkleqgdrqglqegpkISFkeiatkhWRSLLACIGLVIAT-NVTYY 276
Cdd:cd17323 150 LGWRWIFWFLAIISGFCLIL------------------------------IFL-------FLPIVLLLGLYVGLvYAILY 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 277 MLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRR---------------PFVIMGS----IALFV 337
Cdd:cd17323 193 LFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRRlkkknggkpepearlPPAFIGAflfpIGLFI 272
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 749612430 338 LAIPAF-------ILINSNVIG--LIFAGLLMLAVILNCFTGVMASTLPAMfpTHIRySALAAAF 393
Cdd:cd17323 273 FGWTIYphihwivPIIGSAFFGfgLMLIFQSSLTYLVDSYPKYAASALAAN--TLVR-SIFAAIF 334
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
254-453 |
7.61e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.88 E-value: 7.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 254 ATKHWRSLLACIGLVIATNVTYYMLLTYMPSyLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPfVIMGSI 333
Cdd:COG0477 9 TRRRRRALLALALGTFLEGLDFTIVNVALPS-IAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR-VLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 334 ALFVLAIpAFILINSNVIGLIFAGLLMlAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVES 413
Cdd:COG0477 87 LLFGLAS-LLCGLAPSPELLIAARALQ-GIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 749612430 414 SqNLMMPAYYLMVIAVVGLITGVTMKETANQPLKGATPAA 453
Cdd:COG0477 165 L-GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALAL 203
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
268-463 |
8.26e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.96 E-value: 8.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 268 VIATNVTYYMLLTYMPSYLSHnLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGsIALFVLAIPAFILIN 347
Cdd:cd17325 5 LFLDMLGYGIIIPILPLYAES-LGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLG-LLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 348 sNVIGLIFAglLMLAVILNCFTGVMASTLPA-MFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESsqnLMMPAYYLMV 426
Cdd:cd17325 83 -SYWQLLLA--RFLQGLASAAVWPAAMALIAdIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA---LGYRAPFLVC 156
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 749612430 427 IAVVGLITGVT---MKETANQPLKGATPAASDIQEAKEIL 463
Cdd:cd17325 157 AALALLALVLAlllLPEPRPPPNKRAVSAARLRSGLRLLL 196
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
80-389 |
1.13e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 47.69 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 80 PLGGLFFGMLGDKYGRQK-ILAITIVIMSISTFCIGLIP--SYASIGIWAPILLLLCKMAQGFSvggeYTGASIFVAEYS 156
Cdd:pfam13347 51 PIVGHIIDRTRTRWGRRRpWLLLSAIILAVSFILLFTPPelGRAPLFIWLLATYILLRIAYTFF----EIPYWSLGPELT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 157 PDRK-RGFMGSWLDFGSIAGFVLGA---GVVVLISTVVGEDNFlewGWRIPFFLALPLGLIGLYLRHALEETPAFQQHVD 232
Cdd:pfam13347 127 RDYDeRTSLTSYRSFFSVGGGLLAAalaFPLVLILGGTGLERK---GYRIFALIGAVLMLLGVIITAAGTKERVSMRSKE 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 233 KLEQGDRQGLQEGPKISFKEiatKHWRSLLACIGLVIATNVTYYMLLTY-MPSYLSHNLHYSedhgvLIIIAIMIGMLFV 311
Cdd:pfam13347 204 DTGQKEAGSLLDMLKEVFRN---RAFLILLASFLLAALAMGVLNGLLLYyFRYVLGNGFAAS-----AFPLVFTIGALLG 275
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 749612430 312 QPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFILINSNVIglifaGLLMLAVILNCFTGVMASTLPAMFPTHIRYSAL 389
Cdd:pfam13347 276 IPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTL-----LFLVLYIIIGFGYGSSFFLPWSMLADVVDYGEL 348
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
271-417 |
1.44e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 47.22 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 271 TNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIaLFVLAIPAFILINSnv 350
Cdd:cd17329 11 NRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLL-LRALGFALLGFAHS-- 87
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749612430 351 igliFAGLLMLAVILNCFTGVMASTLPAMF-----PTHIR--YSALAAAFNISVLVAGLtptLAAWLVESSQNL 417
Cdd:cd17329 88 ----PWLFAIALVLTGFGGGLFEPASEAMIadvttPENRTraFSLLYWAINLGVAIGPL---LGGLLLLYSFRL 154
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
73-168 |
1.59e-05 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 47.66 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASigiwapilLLLCKMAQGFSVGGEYTGASIFV 152
Cdd:TIGR01299 209 LIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGF--------FLFCRLLSGFGIGGAIPIVFSYF 280
|
90
....*....|....*.
gi 749612430 153 AEYSPDRKRGFMGSWL 168
Cdd:TIGR01299 281 AEFLAQEKRGEHLSWL 296
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
297-383 |
3.43e-05 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 46.19 E-value: 3.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 297 GVLIIIA-IMIGMLFVQPIMGLLSDRFGRRPFVIMGSI--ALFVLAIPafiLINSNVIGLIFAgllMLAVILNCFtgVMA 373
Cdd:cd17396 36 GVAYVISgIGIGRLLTILFAGVLSDKFGRKPSVLLGMVlyALFFVGIL---FSPNLIIAYVFA---LLAGAANSF--LDT 107
|
90
....*....|...
gi 749612430 374 STLPAM---FPTH 383
Cdd:cd17396 108 GTYPALmeaFPKA 120
|
|
| xylE |
PRK10077 |
D-xylose transporter XylE; Provisional |
81-392 |
3.70e-05 |
|
D-xylose transporter XylE; Provisional
Pssm-ID: 182225 [Multi-domain] Cd Length: 479 Bit Score: 46.22 E-value: 3.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSIStfciGLIPSYASIGIWAP--------ILLLLCKMAQGFSVGGEYTGASIFV 152
Cdd:PRK10077 70 IGGALGGYCSNRFGRRDSLKIAAVLFFIS----ALGSAWPEFGFTSIgpdntgyvPEFVIYRIIGGIGVGLASMLSPMYI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 153 AEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTvvGEDNflEW----GWRIPFFL-ALPLGLIGLYLrHALEETPAF 227
Cdd:PRK10077 146 AEIAPAHIRGKLVSFNQFAIIFGQLVVYFVNYFIAR--SGDA--SWlntdGWRYMFASeAIPALLFLMLL-YFVPETPRY 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 228 QQHVDKLEQ---------GDRQGLQEGPKI--SFKEIATKHWRSLLACIGLV------------IATNVTYYmlltYMPS 284
Cdd:PRK10077 221 LMSRGKQEQaegilrkimGNTLATQALQEIkhSLDHGRKTGGKLLMFGVGVIvigvmlsvfqqfVGINVVLY----YAPE 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 285 YLShNLHYSEDHGVL-IIIAIMIGMLF-VQPIMGLlsDRFGRRPFVIMGSIalfVLAIPAFILINSNVIGLIfaGLLMLA 362
Cdd:PRK10077 297 IFK-TLGASTDIALLqTIIVGVINLTFtVLAIMTV--DKFGRKPLQIIGAL---GMAIGMFSLGTAFYTQAP--GIVALL 368
|
330 340 350
....*....|....*....|....*....|....*..
gi 749612430 363 VILNCFTGVMASTLPA-------MFPTHIRYSALAAA 392
Cdd:PRK10077 369 SMLFYVAAFAMSWGPVcwvllseIFPNAIRGKALAIA 405
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
55-433 |
3.85e-05 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 46.46 E-value: 3.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 55 FFPGADPSVQMVAALATFSVPFLirplggLFF---GMLGDKYGRQKILAIT----IVIMSISTFCiglipsYASIGIWAP 127
Cdd:PRK08633 39 AYDGSEQVILTAIVNALFLLPFL------LLSspaGFLADKFSKNRVIRIVklfeVGLTLLIVLA------YYLGWFWLA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 128 ILLLLCKMAQgfsvggeytgASIF-------VAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTVVGEDNFLEWG- 199
Cdd:PRK08633 107 FAVTFLLGAQ----------SAIYspakygiIPELVGKENLSRANGLLEAFTIVAILAGTALFSFLFESVNGNTPSEILg 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 200 --WRIPFFLaLPLGLIGLYLRHALEETPAFQQhvdklEQGDRQglqegPKISFKEIA--TKHWRS----LLACIGLVIAT 271
Cdd:PRK08633 177 riAPAGLVL-LAVAVLGLIFAYRLPKVPAAAP-----EVFDKK-----KYLFPKLLWrnLKLLRSdrvlWLAIIGLSYFW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 272 NVTYYMLLTYmPSYLSHNLHYSEDHGV-LIIIAIMIGMLFVQPIMGLLSDR---FGRRPFVIMGsIALFVLAIPAFILIN 347
Cdd:PRK08633 246 FISQLAQANF-PAYAKEVLGLDNTFQVqYLLAASAIGIGIGSLLAGRLSGRhieLGLVPLGALG-LALSLFLLPTAPSLA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 348 SNVIGLIFAGLL--MLAVILNCFTGVMAstlpamfPTHIRYSALAAA-F--NISVLVAGLTPTLAAWLVESSQNLMmpaY 422
Cdd:PRK08633 324 SVLVLFFLFGFSagLFIVPLNALIQFRA-------PEKELGKVLAANnFlqNVGMLLFLALTTLFSGLGLSPAGLF---Y 393
|
410
....*....|.
gi 749612430 423 YLMVIAVVGLI 433
Cdd:PRK08633 394 LIALVTLIGTL 404
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
81-206 |
4.24e-05 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 45.49 E-value: 4.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYasigIWAPILLLLCkmaqGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17446 48 VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSF----PIYCVFRFLT----GMALSGIVLNSVSLNVEWMPTRV 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAGVVVLIStvvgednflEWGW-----RIPFFL 206
Cdd:cd17446 120 RAVVGTLLGYCYTLGQLILAGVAYAIR---------DWRWlqlavSLPFFI 161
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
298-428 |
4.49e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 46.08 E-value: 4.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 298 VLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIalfvLAIPAFIL------INSNVIGLIFAGLLMLAVILncftgv 371
Cdd:cd06179 35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNL----LGVVGSIVagtaksVNMLIGGQALIGIGAGTQGL------ 104
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 749612430 372 MASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSQNLMMPAYYLMVIA 428
Cdd:cd06179 105 GAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAGWRWIFYINAIF 161
|
|
| MFS_GLUT12_Class3 |
cd17435 |
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
81-227 |
5.17e-05 |
|
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340993 [Multi-domain] Cd Length: 376 Bit Score: 45.56 E-value: 5.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYasigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17435 51 LASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSY--------TVLIVGRIAIGVSISLSSIATCVYIAEIAPQHR 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAGVVVLISTVVGednflewGWRIPFFLALPLGLIGLYLRHALEETPAF 227
Cdd:cd17435 123 RGLLVSLNELMIVIGILLAYISNYAFANVSN-------GWKYMFGLVIPLAALQAIAMYFLPPSPRF 182
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
73-168 |
7.99e-05 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 45.29 E-value: 7.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 73 SVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIFV 152
Cdd:cd17440 41 SIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYG--------LFLFCRLLSGFGIGGAVPTVFSYF 112
|
90
....*....|....*.
gi 749612430 153 AEYSPDRKRGFMGSWL 168
Cdd:cd17440 113 AEVLAREKRGEHLSWL 128
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
81-168 |
8.27e-05 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 44.91 E-value: 8.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17438 49 AGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYG--------AFLFCRLISGFGIGGSLPIVFAYFSEFLAREK 120
|
....*...
gi 749612430 161 RGFMGSWL 168
Cdd:cd17438 121 RGEHLSWL 128
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
81-213 |
1.04e-04 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 42.25 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:TIGR00880 13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNIT--------VLIIARFLQGFGAAFALVAGAALIADIYPPEE 84
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAgvvvLISTVVGEdnflEWGWRIPFFLALPLGLI 213
Cdd:TIGR00880 85 RGVALGLMSAGIALGPLLGP----PLGGVLAQ----FLGWRAPFLFLAILALA 129
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
250-445 |
1.40e-04 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 44.16 E-value: 1.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 250 FKEIATKHWRSLLACIGLVIatnvtyYMLLTY------MPSYLS--HNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDR 321
Cdd:PRK15402 1 LSPLARLGRQALLFPLCLVL------FEFATYiandmiQPGMLAvvEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDR 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 322 FGRRPfVIMGSIALFVLAIPAFILINS----------NVIGLIFAGLLMLAVILNCFTGVMAstlpamfpthIRYSALAA 391
Cdd:PRK15402 75 IGRRP-VMLAGVAFFILTCLAILLAQSieqftllrflQGIGLCFIGAVGYAAIQESFEEADA----------IKITALMA 143
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 749612430 392 afNISVLVAGLTPTLAAWLVEssqnlMMPAYYLMV-IAVVGLITGV----TMKETANQP 445
Cdd:PRK15402 144 --NVALLAPLLGPLVGAALIH-----VLPWRGMFVlFAALAALSFFglwrAMPETAGRV 195
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
261-393 |
2.11e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.69 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 261 LLACIGLVIATNVTYYM-LLTYmpsyLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPfVIMGSIALFVLA 339
Cdd:cd17324 3 ALALAAFAIGTTEYVIQgLLPD----IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRR-LLLVLLLLFILG 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 749612430 340 IpaFILINSNVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAF 393
Cdd:cd17324 78 N--LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVF 129
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
23-215 |
2.77e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.97 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 23 LRKAITAASLGNAMEWFdfGVYGFVAYaLGKVFFPGADPSVQMVAALATFSVpfLIRPLGGLFFGMLGDKYGRQKILAIT 102
Cdd:cd17316 175 LRRRTLLLILLWFFISF--GYYGLTTF-LPTYLQTVLGLSPATSSLYLLLIS--LGALVGALIAGLLSDRIGRKKTLVIG 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 103 IVIMSISTFCIGLIPSYasigiwAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGV 182
Cdd:cd17316 250 LILSGILALPLFYLLSG------SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPL 323
|
170 180 190
....*....|....*....|....*....|...
gi 749612430 183 VVLISTVVGednflewGWRIPFFLALPLGLIGL 215
Cdd:cd17316 324 IALLLASTG-------GTGVPALILALLAIVAL 349
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
71-436 |
4.96e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.21 E-value: 4.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 71 TFSVPFLIrplGGLFFGMLGDKYGRQKILAITIvimsISTFCIGLIPSYASiGIWapiLLLLCKMAQGFSVGgeYTGASI 150
Cdd:cd17331 43 TFSVLQLV---GGPLFGRFGDLFGPRAALVLSF----LSSALSYLLLAFAS-SVP---MLFLSRLPSVFMHA--MQAAQM 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 151 FVAEYSPDRKR----GFMGswLDFGsiAGFVLGAGVVVLISTVVGEdnflewgwRIPFFLALPLGLIGLYLRHALEETPa 226
Cdd:cd17331 110 VVTDLTDPGERaaalGRLG--LSYG--IGMVVGSFLGGLLTKKFGE--------QAAALVAAVGSLLSIVLVILLIPSN- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 227 FQQHVDKLEQGDRQGLQEGPKISFKEIAT--KHWRSLLACIGLVIATNVTYYMLltymPSYLSHNLHYSEDHGVLIIIAI 304
Cdd:cd17331 177 TKSKREKEAKESASPPSVFNLKEILRLLRlpGVAFLLLVKLLSGLPIGMFQSMF----SLVAMDFFGLTPEENGYLMSYA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 305 MIGMLFVQPI-MGLLSDRFGRRpFVIMGSIALFVLAIPAFILINSNVIGLIFAGLLMLAviLNCFTGVMASTLPAMFPTH 383
Cdd:cd17331 253 GVLGMVVQGLlVGPLTKRFGER-SLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIG--GSVLYTVITSLLTKAVPPE 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 749612430 384 IRYSALAAAFNISVLVAGLTPTLAAWLVessQNLMMPAYYLMVIAVVGLITGV 436
Cdd:cd17331 330 DTGTALGLSHALFSLVRTVSPTIGGALL---QAYGFPSFGLLGAAINGLLTVY 379
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
261-433 |
5.58e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 42.15 E-value: 5.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 261 LLACIGLVIAtNVTYYMLLTYMPSYLShNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMgSIALFVLAI 340
Cdd:cd17352 186 VLLALGVSFA-MLGFFVPFVYLPSYAK-SLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLY-IFTLLILGL 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 341 PAFILINSNviglIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLT----PTLAAWLVESSQN 416
Cdd:cd17352 263 SLLAFPLAT----TYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAalvgPPIAGLLRDYTGD 338
|
170
....*....|....*..
gi 749612430 417 LMMPAYYLMVIAVVGLI 433
Cdd:cd17352 339 YDAAFYFCGACLLLSGV 355
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
81-340 |
5.98e-04 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 42.34 E-value: 5.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASIGIWapiLLLLCKMAQGF--SVGGEYTGASIfvAEYSPD 158
Cdd:PRK09556 79 VGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLG---LMIALWALSGFfqSTGGPCSYSTI--TRWTPR 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 159 RKRG-FMGSWLDFGSIAGfVLGAGVVVLISTVVGEDNFLewGWRI-PFFLALPLGLIGLYLRH---------ALEETpaF 227
Cdd:PRK09556 154 RKRGrFLGFWNISHNLGG-AGAGGVALWGANYFFDGHVI--GMFIfPSIIALIIGFIGLRYGSdspeelgwgKAEEI--F 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 228 QQHVDKlEQGDRQGLQEGPKISFKEIATKHWRSLLACIglviaTNVTYYMLL----TYMPSYLSHNLHYSEDHGVLIIIA 303
Cdd:PRK09556 229 GEPISE-EDKETESTDMTKWQIFVEYVLKNPVIWLLCF-----ANIFLYIVRigidNWSPVYAFQELGFSKEDAINTFTL 302
|
250 260 270
....*....|....*....|....*....|....*...
gi 749612430 304 IMIGMLFVQPIMGLLSDRF-GRRPFVIMGSIALFVLAI 340
Cdd:PRK09556 303 FEIGALVGSLLWGWLSDLAnGRRALVACIALALIIFTL 340
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
81-438 |
7.30e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.83 E-value: 7.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASIGIWapilLLLCKMAQGFSvggeYTGASIFVAEYSPDRK 160
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIA----LVLTGFGGGLF----EPASEAMIADVTTPEN 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 161 RGFMGSWLDFGSIAGFVLGAgvvvLISTVVGEDNFlewgwrIPFFLALPLGLIGLYLRHALEETPAFQQHVDKLEQGDRQ 240
Cdd:cd17329 122 RTRAFSLLYWAINLGVAIGP----LLGGLLLLYSF------RLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILR 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 241 GLQegpkisfkeiATKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSE-DHGVLIIIAIMIGMLFvQPIMGLLS 319
Cdd:cd17329 192 GYK----------IVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGEsLLGLLLALNALLIVLL-QFPVARLV 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 320 DRFGRRpFVIMGSIALFVLAIPAFILINSnvigliFAGLLMLAVILNCFTGVMASTLPA----MFPTHIR---YSALAAA 392
Cdd:cd17329 261 ERFRLR-KILMIGILLFAIGFAVLAFANT------LAVLILAMIVLTLGEMLVFPAVQTlvaaLAPPDKRgsyMGFYALA 333
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 749612430 393 FNISVLVAGLtptLAAWLVESSQNLMMpayyLMVIAVVGLITGVTM 438
Cdd:cd17329 334 WGLGRAIGPL---VGGLLLDLLGPGLP----WLILAALGLIAAALL 372
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
65-214 |
8.07e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.87 E-value: 8.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 65 MVAALATFSVpflirpLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPsyasigiWAPILLLLCKMAQGFSVGGE 144
Cdd:cd17355 250 ALALIGLFNI------VGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLP-------FPPLALLLFAALFGLGWGAT 316
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 145 YTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTVVGednflewGWRIPFFLALPLGLIG 214
Cdd:cd17355 317 VPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG-------SYTAAWALAVALGLIA 379
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
81-168 |
9.22e-04 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 41.55 E-value: 9.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASigiwapilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17439 49 VGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGT--------FLFCRLLSGVGIGGSIPIVFSYFSEFLAQEK 120
|
....*...
gi 749612430 161 RGFMGSWL 168
Cdd:cd17439 121 RGEHLSWL 128
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
261-412 |
1.44e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.02 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 261 LLACIGLVIATNVTYYMLLTYMPSyLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGsIALFVLAi 340
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPA-IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAG-LLLFILA- 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 749612430 341 pAFILINSNVIGLIFAGLLMLAVILnCFTGVMASTLPAMFPTHIR----YSALAAAFNISVLVAgltPTLAAWLVE 412
Cdd:cd17320 78 -SLLCALASSIEQLLIARFLQGLGA-AAGSVVARAIVRDLYSGAElakiFSLLMMILAIAPALA---PLLGGLLLL 148
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
274-363 |
1.47e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 41.19 E-value: 1.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 274 TYYML---LTYMPSYLsHNLHYSEDHGVLIIIAIMiGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIpafILINSNV 350
Cdd:pfam06609 56 TYFVLqasASALPNIL-QDIGQSENQGLFSTLWTM-GQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAI---VGCTANK 130
|
90
....*....|...
gi 749612430 351 IGLIFAGLLMLAV 363
Cdd:pfam06609 131 FNTLLAAMTLLGV 143
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
44-185 |
1.63e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 44 YGFVAYALGKVFFPGAdpsvqmvAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSyaSIG 123
Cdd:cd17370 219 FAFLILRAQELGLSAA-------LIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSS--LWL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 124 IWAPILLLlckmaqGFSVGGEYTGASIFVAEYSPDRKRG--------------FMGSWL------DFGSIAGFVLGAGVV 183
Cdd:cd17370 290 LLLGFILW------GLYMGAQESIERAAVADLVPAELRGtayglfntvvgigwLLASLIagylwdLISPSAAFLFSAVLA 363
|
..
gi 749612430 184 VL 185
Cdd:cd17370 364 LI 365
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
71-380 |
1.86e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 40.38 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 71 TFSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVIMSISTFcigLIPSYASIGIWAPILLLLckmaqGFSVGGEYTGASI 150
Cdd:cd17333 36 IFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALA---LIFATPSIYLFVVLMFLA-----GLGAGILDTGANT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 151 FVAEYSPdRKRGFMGSWLDFGsiagFVLGAGVVVLISTVVGeDNFLEWGW--RIPFFLALPLGLIGLYLRhaleetpaFQ 228
Cdd:cd17333 108 FVGALFE-ESSATRLNVLHGF----FGLGALIGPLIATSLL-TSELSWSWayLIIGLIYLLLAILILLTL--------FP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 229 QHVDKLEQGDRQGLQegPKISFKEIATKHWRSLLACIGLVIATNVTYYmllTYMPSYLSHNLHYSEDHGVLIIIAIMIGM 308
Cdd:cd17333 174 ELPSARNPQQSVGAF--SASASRLLRNPSIILGALALFLYVGAETAFS---SWVPSYLVEKKHVSDGLAGYLLSGFWVGI 248
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 749612430 309 LFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIpaFILINSNVIGLIFAGLLmlavilnCFTGvMASTLPAMF 380
Cdd:cd17333 249 TIGRLLGGPISRRIKPHTLLVLSGSGALLGLL--ILLLAPTLVVGLVATAL-------LGLF-MAALFPTIL 310
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
61-422 |
1.90e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 40.57 E-value: 1.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 61 PSVQMvaALATfSVPFLIRPLGGLFFGMLGDKYGRQKILAITIVImsisTFCIGLIPSYASIGIWapilLLLCKMAQGFS 140
Cdd:cd17441 32 PSWQV--ALLT-SVVFIGMMLSSSLWGNISDQYGRKTGLKISVLW----TLYYGILSAFAPIYSW----ILVLRGLVGFG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 141 VGGEYTGASIFvAEYSPDRKRGFMGSWLDfgsiAGFVLGAGVVVLISTVVGEdnflEWGWRIPFFL-ALPLGLIGLyLRH 219
Cdd:cd17441 101 IGGVPQSVTLY-AEFLPMKSRAKCILLIE----VFWALGTVFEVLLAVFVMP----TLGWRWLLILsALPLLIFAV-LCF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 220 ALEETPAFQQHV-------------DKLEQGDRQGLQEGPKISFKEIATKHWRSLLACIGLviatNVTYYMLLtympsyL 286
Cdd:cd17441 171 WLPESARYWTTIllwfiwfsnafsyYGLVLLTTELFQAGDVCSGSSGKKVEGKCSLECEYL----TTSDYMDL------L 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 287 SHNLhySEDHGVLIIIAIMigmlfvqpimgllsDRFGRRPFVIMGSIALFVLAIPAFILINSNVIGLIFagLLMLAVILN 366
Cdd:cd17441 241 WTTL--SEFPGLLVTLWII--------------DRFGRKKTMALCFFVFSFCTLLLFSCVGRFSLTVLL--FIARAFISG 302
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 749612430 367 CFTGVMASTlPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVESSQNLMMPAY 422
Cdd:cd17441 303 GFQAAYVYT-PEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLSVY 357
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
87-367 |
2.02e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 87 GMLGDKYGRQKILAITIVIMSISTFcigLIPSYASIGIWApilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKR----G 162
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLATL---LTPLLAYSSLPL---LILSRILLGLGEGVHFPSMTSLFSRWVPVSERsravS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 163 FMGSWLDFGSIAGFVLGAgvvVLISTvvgednfleWGWRIPFFLALPLGLIGLYLRHALEetpafqqhvdkleqgdrqgl 242
Cdd:cd17380 129 IVTAGSYLGTLLGGLIGP---LLLEY---------YGWPSVFYFFGLLGLLWALVWLIYL-------------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 243 qegpkisfkeiatkhwRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIgMLFVQPIMGLLSDRF 322
Cdd:cd17380 177 ----------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVLVPLAKGWVFNVVPWLV-MFPSSNVAGWLADHL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 749612430 323 GRRPFV------IMGSIALFvlaIPAFILINSNVIGLIFAGLLMLAVILNC 367
Cdd:cd17380 240 ISRGWTvtsvrkLMQSIGFL---GPALFLLLLSHTDSFSLALLCMSVALGL 287
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
277-433 |
2.03e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 40.25 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 277 MLLTYMPSYLSHNLHYSEDHGV--LIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMG------SIALFVLAIPAFILINS 348
Cdd:cd17330 14 IVFPVLPFYVREFNKLGASGYYvgLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSlagsavSYVLLGLSRNLWLLFLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 349 NVIGLIFAGLlmLAVILNCFTGVMASTLPAmfpthIRYSALAAAFNISVLvagLTPTLAAWLVeSSQNLMMPAYYLMVIA 428
Cdd:cd17330 94 RFLDGLTGGN--VSVAQAYIADITDEEERA-----KAFGIISAAFGLGFI---LGPALGGFLS-TPYGYALPFLVAAALA 162
|
....*
gi 749612430 429 VVGLI 433
Cdd:cd17330 163 LLNLV 167
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
84-371 |
2.10e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 40.36 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 84 LFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYASIGIWAPILLllckmaqGFsVGGEYTGASIFVAEYSPDRKRG- 162
Cdd:TIGR00886 55 IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYSVLLLIRLFI-------GI-AGGSFASCMPWISFFFPKKIQGt 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 163 ---FMGSWLDFGSIAGFVLGAGVVVLISTVVGEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAfqqhvdkleqgdr 239
Cdd:TIGR00886 127 algLAAGWGNMGGGVAQFVMPPIIGSLIFGGGQPAHLAWGWAFVIVPAGILLLPALLIFFVGADTPP------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 240 qGLQEGPKISFKEIATKHWRSLLACIGLVIATNVTYYMLLTYMPSYLSHNLHYSEDHGVLIIIAIMIGM-LFVQPIMGLL 318
Cdd:TIGR00886 194 -GKPATGKLSFKEALKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKDQFGLSKVQAGAYASLGGFLgSLARPAGGAI 272
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 749612430 319 SDRFGRRPFVIMGSIAlfvLAIPAFILINSNVIGLIFAGLLMLAVILNCFTGV 371
Cdd:TIGR00886 273 SDRLGGARKLLMNFLG---VAMGAFLVVLGLVSDGSLAAFIVLFVALFFFAGA 322
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
29-399 |
2.17e-03 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 40.31 E-value: 2.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 29 AASLGNAMEWFDFGVYGFVAY--ALGKVFFPG----------------ADPSVQMVAalatfSVPFLIRPLGGLFFGMLG 90
Cdd:cd17361 1 VAALGGLIFGYDIGISGGVTSmdPFLEKFFPSvyekkkgasennyckyDDQLLQLFT-----SSLYLAGLVASLLASYVT 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 91 DKYGRQkilaITIVIMSIStFCIGLIPSYASIGIWApilLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMgswldf 170
Cdd:cd17361 76 RKWGRK----PSMLIGGVL-FLVGAALNAAAQNIAM---LIVGRILLGFGVGFGNQAVPLYLSEMAPAKLRGAL------ 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 171 gsIAGFVLGAGVVVLISTVV--GEDNFLEWGWRIPFFLALPLGLIGLYLRHALEETPAFQQhvdkleqgdrqglqegpki 248
Cdd:cd17361 142 --NIGFQLAITIGILIANLInyGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPETPNSPQ------------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 249 sfkeiatkhwrsLLACIGLVIATNVT-YYMLLTYMPSYLShNLHYSEDhGVLIIIAIMIGMLFVQPIMG-LLSDRFGRRP 326
Cdd:cd17361 201 ------------LVIAILIPFFQQLTgINVIMFYAPVLFQ-TLGFGSD-ASLISAVITGAVNVVSTLVSiYLVDRFGRRF 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 327 FVIMGSIALFV--LAIPAFILINSNVIGLIFAGLLMLAVILNC-----FT---GVMASTLPA-MFPTHIRysalAAAFNI 395
Cdd:cd17361 267 LLLEGGVQMLAsqVAIGILLAVKFGDGGELPKAYAIAVVVLIClyvaaFAwswGPLGWLVPSeIFPLETR----SAGQSL 342
|
....
gi 749612430 396 SVLV 399
Cdd:cd17361 343 TVAV 346
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
272-364 |
2.18e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.30 E-value: 2.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 272 NVTYYMLLTYMPSYLShNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDR----FGRR-PFVIMGSialfVLAIPAFILI 346
Cdd:cd17313 12 EFGWALENSYVPPILQ-TLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRcnsrIGRRrPFILVGA----PLAALGLILI 86
|
90 100
....*....|....*....|....
gi 749612430 347 -NSNVIGLIFAGL-----LMLAVI 364
Cdd:cd17313 87 pNAADIGLALGDGprtwaLVLFVL 110
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
278-371 |
3.35e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 39.87 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 278 LLTYMPSYLsHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPFVIMGSIALFVLAIPAFIlinsnVIGLIFAG 357
Cdd:cd17335 16 LLPFLSVYL-KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLF-----FVAQIFWL 89
|
90
....*....|....
gi 749612430 358 LLMLAVILNCFTGV 371
Cdd:cd17335 90 LLLLVILGAFFSAP 103
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
81-168 |
3.40e-03 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 39.78 E-value: 3.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYAsigiwapiLLLLCKMAQGFSVGGEYTGASIFVAEYSPDRK 160
Cdd:cd17363 49 VGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYG--------FFLFCRLLSGIGIGGSIPIVFSYFAEFLAREK 120
|
....*...
gi 749612430 161 RGFMGSWL 168
Cdd:cd17363 121 RGEHLSWL 128
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
59-358 |
3.79e-03 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 39.47 E-value: 3.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 59 ADPSVQMVAALATF--SVPFLIRPLGGLFFGMLGDKYGRQkilaITIVIMSIStFCIGLIPSYASIGIWapiLLLLCKMA 136
Cdd:cd17433 32 ADPALRLDDAAASWfgSVVTLGAAAGGVLGGWIVDRAGRK----LSLMLCSVP-FIAGFTVITAAQNVW---MLYVGRLL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 137 QGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGfVLGAGVVVListvvgednFLEWGWrIPFFLALPLGLIgLY 216
Cdd:cd17433 104 TGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIG-IMGAYLAGL---------VLDWRW-LAVLGSIPPTLM-LL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 217 LRHALEETPAF-------QQHVDKLE--QGDRQGLQEGP---KISFKEIATKHWRSLLACIGLVIATNVTYYMLLTYMPS 284
Cdd:cd17433 172 LMCFMPETPRFlltqhrrQEAMAALRflRGPDQGWEWECigiEQSFHLEEQSFSLALLKQPGIYKPLIIGVSLMAFQQLT 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 285 YLSHNLHYSE---------DHGVLIIIAIMIGMLFVqPIMGLLSDRFGRRPFVIMGSIALfVLAIPAFILINSNVIGLIF 355
Cdd:cd17433 252 GINAVMFYAEtifeeakfkDSSVASVIVAAIQVLFT-AVAALIMDRAGRKVLLVLSGVVM-VFSTAAFGWLAVGSMGFFI 329
|
...
gi 749612430 356 AGL 358
Cdd:cd17433 330 AGF 332
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
80-206 |
4.08e-03 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 39.20 E-value: 4.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 80 PLGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYasigiwaPILLLLcKMAQGFSVGGEYTGASIFVAEYSPDR 159
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTF-------PVYCVL-RFLAGFAVSGISINTLILGTEWTTPR 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 749612430 160 KRGFMGSWLDFGSIAGFVLGAGVVVLIStvvgednflEWGW-----RIPFFL 206
Cdd:cd17374 121 HRALAITLTSCFFSIGQMLLAGLAYAIR---------DWRLlqlvvSVPFFL 163
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
257-412 |
4.67e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 39.18 E-value: 4.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 257 HWRSLLACIGLVIAT-NVTYYMLLTYMPsyLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPfVIMGSIAL 335
Cdd:cd17355 1 GWVVLAVTFLILILSwGIRYYFGVFIIP--IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRR-VMLLGLLL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 749612430 336 FVLAIPAFILINSnVIGLIFAGLLMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVE 412
Cdd:cd17355 78 LAAGLVLLALATS-LWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE 153
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
81-408 |
4.86e-03 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 39.26 E-value: 4.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 81 LGGLFFGMLGD-KYGRQKILAITIVIMSISTFCIGLIPSYasigiWAPILLllcKMAQGFSVGGEYTGASIFVAEYSPDR 159
Cdd:cd17378 48 IGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNY-----WVYAFL---RFLTGFGRSGIGTCALVLATEPVGPK 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 160 KRGFMGSWLDFgsiaGFVLGAGVVVLISTVVGEDnflewgWRIpfflalplgligLYLRHALeetpafqqhvdkleqgdr 239
Cdd:cd17378 120 WRGQVGMSTFF----FFVLGFMSLPGIAYLNGSS------WRV------------LYFWTSI------------------ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 240 qglqegPKISFKEIATKHWRSLLACIGLVIATNVTYYMlltyMPSYLShNLHYSEDHGVLIIIAIMIGMLFVQPIMgllS 319
Cdd:cd17378 160 ------PALIYCILVYLFARRLLAVMVIGFGIGMVYYG----IPLAVG-NLKFNIYLSVALNALSELPAFVITAFL---L 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 320 DRFGRRPFVIMGSIALFVLAIPAFILINSNVIGLIFAglLMLAVILNCFTG--VMASTLPAMFPTHIRYSALAAAFNISV 397
Cdd:cd17378 226 DRFGRRPSLLGFTLLSGASCLLCFVLSIGGTTSLQIA--LELVGFFGAAGAfnLLYIYTVELFPTCVRNAALGMLRQALV 303
|
330
....*....|.
gi 749612430 398 LVAGLTPTLAA 408
Cdd:cd17378 304 VGGIFAPFIVS 314
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
70-208 |
6.67e-03 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 38.87 E-value: 6.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 70 ATFSVPFLIrplGGLFFGMLGDKYGRQKILAITIVIMSISTFCIGLIPSYasigiwapILLLLCKMAQGFSVGGEYTGAS 149
Cdd:cd17379 40 SSLNLGFLI---GSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNY--------PWFLIFRFLQGLFGKGGWMTGY 108
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 749612430 150 IFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVVVLISTvvgednfleWGW-----RIPFFLAL 208
Cdd:cd17379 109 VLVTEFVGSKYRRTVGIVYQMFFTLGLLILPGIAYFIPH---------WRWlqlavTLPNFLFL 163
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
281-413 |
7.09e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 38.71 E-value: 7.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749612430 281 YMP--SYLSHNLHYSEDHGVLIIIAIMIGMLFVQPIMGLLSDRFGRRPfVIMGSIALFVLAIPAFILinSNVIGLIFAGL 358
Cdd:cd17323 18 YSPalPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRP-VYLVSLFIFVIFQIGCAL--APNIAMLIILR 94
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 749612430 359 LMLAVILNCFTGVMASTLPAMFPTHIRYSALAAAFNISVLVAGLTPTLAAWLVES 413
Cdd:cd17323 95 FLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS 149
|
|
| |
