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Conserved domains on  [gi|748736234|ref|WP_039994351|]
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MULTISPECIES: MMPL family transporter [Mycobacteriales]

Protein Classification

MMPL family transporter( domain architecture ID 11457272)

MMPL family transporter similar to mycobacterial membrane protein large (MMPL) transporters, which function in the export of lipid components across the cell envelope; belongs to a subfamily of the resistance-nodulation-cell division (RND) permeases

Gene Ontology:  GO:0016020|GO:0005215
PubMed:  10941792|28340510
TCDB:  2.A.6

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 32-735 7.85e-161

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


:

Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 481.57  E-value: 7.85e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  32 MARRRRAVLAVWGLLLVVCAVAYPLLENRLGAMDFGVEGSESTEVDRLVARHFPQFGTEQAVIVLQSGAVTATDAEFRAA 111
Cdd:COG2409    1 VARHRWLVLLAWLVLLVALGVLAPQLGGSLSSNGFFLPGSESQRAADLLAEAFPESDGASAVVVVEAPDGTLTDPAFRAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 112 VARTITAATAVEGVVDVVGPYDGLPGSQISADGHVAIALAGMDGDMAERA-KVARDLQDAIATTGDDSIDVGVTGYSAVQ 190
Cdd:COG2409   81 VAALVARLRADPGVAGVQDPWDDPAAGLVSEDGKAALVTVTLDGDAGDEAaEAVDALRDAVAAAPAPGLTVYVTGPAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 191 NAATELQNADLARAEAIGIPVALVLLVLALGALAAAAVPIAVAIAGMLTAVGVLFTLTAVTAFDSLTVAMATMVGLGVGI 270
Cdd:COG2409  161 ADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDVSSFAPNLLTMLGLGVGI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 271 DYAMFIVSRFREELTHHTGPDHAaisgaVGRSLATAGKTILVSGLVVMISLCALIIIQAPIFR----GIAIGVATAVTSM 346
Cdd:COG2409  241 DYALFLVSRYREELRAGEDREEA-----VARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRsmgpAAAIGVAVAVLAA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 347 LTVavtllpallaalgpavnrgsLPA---------RWRPADSATDAPGVLGGRWARWAYLVMRRPVLFGTAAAAVLVLAA 417
Cdd:COG2409  316 LTL--------------------LPAllallgrrvFWPRRPRRRRAAAPESGFWRRLARAVVRRPVPVLVAAVAVLLALA 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 418 LPVFGIRYGLDMGTTALDDTPTGRASTALNTNFPPGALSPVEIIATGPSD-TPLTADAEARVNRFLTEIDGDARIDTVLP 496
Cdd:COG2409  376 LPALGLRLGLPDADSLPADSPSRQGYDALAEHFPPGSNGPLTVVVESDDDlDPADLAALDALAAALAAVPGVASVQPPTR 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 497 AQLNDGRMLAM-AIPSVTFDSMAATDLVRDLRNTAAGA-AGAEIRIGGSTAEFVDLSDEMTTKLPLVVALVLTASLVFLI 574
Cdd:COG2409  456 PEGTDGDAARLqVVPDGDPDSPEAIDLVDRLRDAAAPAlEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLL 535

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 575 AAFRSIALPLKAIAMNLLATGAALGITVAVFQWGLGenVLDFTsPGFVQVYLPTVVFALLFGLSMDYEVFLIRRIREYWD 654
Cdd:COG2409  536 LLFRSVVAPLKAVLTNLLSLGAALGVLVLVFQHGWL--LLGFT-PGPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYD 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 655 ASGDNQRAVAAGLTHTARPITAAAAIMIAIFASFLTADILELKQLGLALAVAVAIDAVLIRLVLVPALMRLLGGWNWWLP 734
Cdd:COG2409  613 RGGGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWNWWLP 692


                 .
gi 748736234 735 A 735
Cdd:COG2409  693 R 693
 
Name Accession Description Interval E-value
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 32-735 7.85e-161

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 481.57  E-value: 7.85e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  32 MARRRRAVLAVWGLLLVVCAVAYPLLENRLGAMDFGVEGSESTEVDRLVARHFPQFGTEQAVIVLQSGAVTATDAEFRAA 111
Cdd:COG2409    1 VARHRWLVLLAWLVLLVALGVLAPQLGGSLSSNGFFLPGSESQRAADLLAEAFPESDGASAVVVVEAPDGTLTDPAFRAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 112 VARTITAATAVEGVVDVVGPYDGLPGSQISADGHVAIALAGMDGDMAERA-KVARDLQDAIATTGDDSIDVGVTGYSAVQ 190
Cdd:COG2409   81 VAALVARLRADPGVAGVQDPWDDPAAGLVSEDGKAALVTVTLDGDAGDEAaEAVDALRDAVAAAPAPGLTVYVTGPAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 191 NAATELQNADLARAEAIGIPVALVLLVLALGALAAAAVPIAVAIAGMLTAVGVLFTLTAVTAFDSLTVAMATMVGLGVGI 270
Cdd:COG2409  161 ADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDVSSFAPNLLTMLGLGVGI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 271 DYAMFIVSRFREELTHHTGPDHAaisgaVGRSLATAGKTILVSGLVVMISLCALIIIQAPIFR----GIAIGVATAVTSM 346
Cdd:COG2409  241 DYALFLVSRYREELRAGEDREEA-----VARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRsmgpAAAIGVAVAVLAA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 347 LTVavtllpallaalgpavnrgsLPA---------RWRPADSATDAPGVLGGRWARWAYLVMRRPVLFGTAAAAVLVLAA 417
Cdd:COG2409  316 LTL--------------------LPAllallgrrvFWPRRPRRRRAAAPESGFWRRLARAVVRRPVPVLVAAVAVLLALA 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 418 LPVFGIRYGLDMGTTALDDTPTGRASTALNTNFPPGALSPVEIIATGPSD-TPLTADAEARVNRFLTEIDGDARIDTVLP 496
Cdd:COG2409  376 LPALGLRLGLPDADSLPADSPSRQGYDALAEHFPPGSNGPLTVVVESDDDlDPADLAALDALAAALAAVPGVASVQPPTR 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 497 AQLNDGRMLAM-AIPSVTFDSMAATDLVRDLRNTAAGA-AGAEIRIGGSTAEFVDLSDEMTTKLPLVVALVLTASLVFLI 574
Cdd:COG2409  456 PEGTDGDAARLqVVPDGDPDSPEAIDLVDRLRDAAAPAlEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLL 535

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 575 AAFRSIALPLKAIAMNLLATGAALGITVAVFQWGLGenVLDFTsPGFVQVYLPTVVFALLFGLSMDYEVFLIRRIREYWD 654
Cdd:COG2409  536 LLFRSVVAPLKAVLTNLLSLGAALGVLVLVFQHGWL--LLGFT-PGPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYD 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 655 ASGDNQRAVAAGLTHTARPITAAAAIMIAIFASFLTADILELKQLGLALAVAVAIDAVLIRLVLVPALMRLLGGWNWWLP 734
Cdd:COG2409  613 RGGGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWNWWLP 692


                 .
gi 748736234 735 A 735
Cdd:COG2409  693 R 693
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 70-405 2.08e-23

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 101.98  E-value: 2.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234   70 GSESTEVDRLVARHFPQFGTEQAVIVLQS-GAVTATDAEFRAAVARTITA----ATAVEGVVDVVGPYDGLPGSQiSADG 144
Cdd:pfam03176   6 DAPSVRAMDRLGAAFPQADSDPIIVVVLGeGDQALGDAAAEAGYDTLVDAlradTGHVGSVQDFWGDPDTAALFV-SPDG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  145 HVAIALAGMDGDMAERA--KVARDLQDAIA-TTGDDSIDVGVTGYSAVQNAATELQNADLARAEAIGIPVALVLLVLALG 221
Cdd:pfam03176  85 KAAYVVVTLEGDPGTTEadESVAAVRDAVEqAPPPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  222 ALAAAAVPIAVAIAGMLTAVGV--LFTLTAVTAFDSLTVAMATMVGLGVGIDYAMFIVSRFREELTHHTGPDHAAIsgav 299
Cdd:pfam03176 165 SVVAALLPLLTVGLSLGAAQGLvaILAHILGIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVI---- 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  300 gRSLATAGKTILVSGLVVMISLCALIIIQAPIFRG----IAIGVATAVTSMLTVAvtllPALLaalgpavnrgSLPARWR 375
Cdd:pfam03176 241 -RAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQvgptIAIGVLVDVLAALTLL----PALL----------ALLGRWG 305

                         330       340       350
                  ....*....|....*....|....*....|
gi 748736234  376 PADSatdAPGVLGGRWARWAYLVMRRPVLF 405
Cdd:pfam03176 306 LWPP---KRDRTARWWRRIGRLVVRRPAPV 332
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 39-502 1.02e-21

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 100.81  E-value: 1.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234   39 VLAVWGLLLVVCAVAYPLLENRLGAMD---FGVEGSESTEVDRLVARHFPQFGTEQAVIVLQSGAVTATDAE--FRAAVA 113
Cdd:TIGR00833   6 IIGVWIATAISLQLLAPLLEDVSYFRLqaeLPGGAASSIAVKEMSAAFQEAIRDPKIILVLESNERLGDKDYatYDALIA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  114 RTITAATAVEGVVDVVGPYDGLPGSQiSADGH---VAIALAGMDGDMAERAKVARDLQDAIATTGDDSIDVGVTGYSAVQ 190
Cdd:TIGR00833  86 KLRADIMHVISVVDFWGPPEAAEGLR-SDDGKatiIIVNLAGEKGQKEAQEAINAVRRIVEQTNAPDGLTVHVTGPLATI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  191 NAATELQNADLARAEAIGIPVALVLLVLALGALAAAAVPIAVAIAGMLTAVGVLFTL--TAVTAFDSLTVAMATMVGLGV 268
Cdd:TIGR00833 165 ADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLgiPGLIGVNAQTTVLLTALVIGA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  269 GIDYAMFIVSRFREELTHHTGPDHaaisgAVGRSLATAGKTILVSGLVVMISLCALIIIQAPIFRG----IAIGVATAVT 344
Cdd:TIGR00833 245 GTDYAVFLTGRYHEERRKGESLEE-----AAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTlgvsCAVGVLVALL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  345 SMLTVavtllpaLLAALGPAVNRGSLPARwrpadsatdAPGVLGGRWARWAYLVMRRP--VLFGTAAAAVLVLAALPvfG 422
Cdd:TIGR00833 320 NAVTL-------TPALLTLEGREGLMKPG---------RKSKIRFIWRRLGTAVVRRPwpILVTTLIISGVSLLALP--L 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  423 IRYGLDMGTTALDDTPTGRASTALNTNFPPGALSPVEIIATGPSDTPLTADAeARVNRFLTEIDGDARIDTVLPAQLNDG 502
Cdd:TIGR00833 382 IRTGYDDEKMIPTDLESVQGYEAADRHFPGNSMDPMVVMIKSDHDVRNPALL-ADIDRFEREIKAVPGINMVQETQRPDG 460
 
Name Accession Description Interval E-value
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 32-735 7.85e-161

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 481.57  E-value: 7.85e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  32 MARRRRAVLAVWGLLLVVCAVAYPLLENRLGAMDFGVEGSESTEVDRLVARHFPQFGTEQAVIVLQSGAVTATDAEFRAA 111
Cdd:COG2409    1 VARHRWLVLLAWLVLLVALGVLAPQLGGSLSSNGFFLPGSESQRAADLLAEAFPESDGASAVVVVEAPDGTLTDPAFRAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 112 VARTITAATAVEGVVDVVGPYDGLPGSQISADGHVAIALAGMDGDMAERA-KVARDLQDAIATTGDDSIDVGVTGYSAVQ 190
Cdd:COG2409   81 VAALVARLRADPGVAGVQDPWDDPAAGLVSEDGKAALVTVTLDGDAGDEAaEAVDALRDAVAAAPAPGLTVYVTGPAALA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 191 NAATELQNADLARAEAIGIPVALVLLVLALGALAAAAVPIAVAIAGMLTAVGVLFTLTAVTAFDSLTVAMATMVGLGVGI 270
Cdd:COG2409  161 ADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAALLPLLTAGLAVGVALGLLALLAAFTDVSSFAPNLLTMLGLGVGI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 271 DYAMFIVSRFREELTHHTGPDHAaisgaVGRSLATAGKTILVSGLVVMISLCALIIIQAPIFR----GIAIGVATAVTSM 346
Cdd:COG2409  241 DYALFLVSRYREELRAGEDREEA-----VARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRsmgpAAAIGVAVAVLAA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 347 LTVavtllpallaalgpavnrgsLPA---------RWRPADSATDAPGVLGGRWARWAYLVMRRPVLFGTAAAAVLVLAA 417
Cdd:COG2409  316 LTL--------------------LPAllallgrrvFWPRRPRRRRAAAPESGFWRRLARAVVRRPVPVLVAAVAVLLALA 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 418 LPVFGIRYGLDMGTTALDDTPTGRASTALNTNFPPGALSPVEIIATGPSD-TPLTADAEARVNRFLTEIDGDARIDTVLP 496
Cdd:COG2409  376 LPALGLRLGLPDADSLPADSPSRQGYDALAEHFPPGSNGPLTVVVESDDDlDPADLAALDALAAALAAVPGVASVQPPTR 455

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 497 AQLNDGRMLAM-AIPSVTFDSMAATDLVRDLRNTAAGA-AGAEIRIGGSTAEFVDLSDEMTTKLPLVVALVLTASLVFLI 574
Cdd:COG2409  456 PEGTDGDAARLqVVPDGDPDSPEAIDLVDRLRDAAAPAlEGAEVLVGGTTAVNIDISDALADDLPLVIPVVLGLIFLLLL 535

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 575 AAFRSIALPLKAIAMNLLATGAALGITVAVFQWGLGenVLDFTsPGFVQVYLPTVVFALLFGLSMDYEVFLIRRIREYWD 654
Cdd:COG2409  536 LLFRSVVAPLKAVLTNLLSLGAALGVLVLVFQHGWL--LLGFT-PGPLDSFVPLLLFVILFGLGMDYEVFLVSRIREEYD 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 655 ASGDNQRAVAAGLTHTARPITAAAAIMIAIFASFLTADILELKQLGLALAVAVAIDAVLIRLVLVPALMRLLGGWNWWLP 734
Cdd:COG2409  613 RGGGTREAVIRGLARTGRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGVLLDAFVVRMLLVPALMALLGRWNWWLP 692


                 .
gi 748736234 735 A 735
Cdd:COG2409  693 R 693
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
27-729 4.30e-37

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 148.85  E-value: 4.30e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  27 RWGVLMARRRRAVLAVWGLLLVVCAVAYPLLENRLGAMDFGVEGSESTEVDRLVARhfpQFGTEQAVIVLQSGAVTATDA 106
Cdd:COG1033    6 RLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEE---EFGGDDTVVVAVEGKDDIFTP 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 107 EFRAAVARTITAATAVEGVVDVVGPYD---------------------------------------GLPGSQISADGHVA 147
Cdd:COG1033   83 ETLEALRELTEELEEIPGVDSVTSLTNvrategtedgltveplipdelpaspeelaelrekvlsspLYVGRLVSPDGKAT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 148 IALAGMDGDMA----ERAKVARDLQDAIATTGDDSIDVGVTGYSAVQNAATELQNADLARAEAIGIPVALVLLVLALGAL 223
Cdd:COG1033  163 LIVVTLDPDPLssdlDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLFLFFRSL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 224 AAAAVPIAVAIAGMLTAVGVLFTLtaVTAFDSLTVAMATMVgLGVGIDYAMFIVSRFREELTHHTGPDHAAIsgavgRSL 303
Cdd:COG1033  243 RGVLLPLLVVLLAVIWTLGLMGLL--GIPLSPLTILVPPLL-LAIGIDYGIHLLNRYREERRKGLDKREALR-----EAL 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 304 ATAGKTILVSGLVVMISLCALIIIQAPIFR--GI--AIGVATAVTSMLTVavtllpallaalgpavnrgsLPA------R 373
Cdd:COG1033  315 RKLGPPVLLTSLTTAIGFLSLLFSDIPPIRdfGIvaAIGVLLAFLTSLTL--------------------LPAllsllpR 374

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 374 WRPADSATDAPGVLGGRWARWAYLVMRRPVLFGTAAAAVLVLAALPVFGIRYGLDMGTTALDDTPTGRASTALNTNFppG 453
Cdd:COG1033  375 PKPKTRRLKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENF--G 452

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 454 ALSPVEIIA-TGPSDTPLTADAEARVNRFLTEIDGDARIDTV---------LPAQLNDGRMLAMAIP------------- 510
Cdd:COG1033  453 GSDPLEVVVdTGEPDGLKDPEVLKEIDRLQDYLESLPEVGKVlsladlvkeLNQALNEGDPKYYALPesrellaqlllll 532

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 511 ---------------------SVTFDSMAATDLVRDLRNTAAGAA------GAEIRIGGSTAEFVDLSDEMTTKLPLVVA 563
Cdd:COG1033  533 ssppgddlsrfvdedysaarvTVRLKDLDSEEIKALVEEVRAFLAenfppdGVEVTLTGSAVLFAAINESVIESQIRSLL 612

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 564 LVLTASLVFLIAAFRSIALPLKAIAMNLLATGAALGItvavfqWGLGENVLDFTSpgfvqvylpTVVFALLFGLSMDYEV 643
Cdd:COG1033  613 LALLLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGL------MGLLGIPLNIAT---------AVVASIALGIGVDYTI 677

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 644 FLIRRIREYWDASGDNQRAVAAGLTHTARPITAAAAIMIAIFASFLTADILELKQLGLALAVAVAIdAVLIRLVLVPALM 723
Cdd:COG1033  678 HFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLV-ALLAALLLLPALL 756


                 ....*.
gi 748736234 724 RLLGGW 729
Cdd:COG1033  757 LLLDPR 762
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 70-405 2.08e-23

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 101.98  E-value: 2.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234   70 GSESTEVDRLVARHFPQFGTEQAVIVLQS-GAVTATDAEFRAAVARTITA----ATAVEGVVDVVGPYDGLPGSQiSADG 144
Cdd:pfam03176   6 DAPSVRAMDRLGAAFPQADSDPIIVVVLGeGDQALGDAAAEAGYDTLVDAlradTGHVGSVQDFWGDPDTAALFV-SPDG 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  145 HVAIALAGMDGDMAERA--KVARDLQDAIA-TTGDDSIDVGVTGYSAVQNAATELQNADLARAEAIGIPVALVLLVLALG 221
Cdd:pfam03176  85 KAAYVVVTLEGDPGTTEadESVAAVRDAVEqAPPPEGLKAYLTGPAATVADLRDAGDRDLGLIEAVTLVVIFIILLIVYR 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  222 ALAAAAVPIAVAIAGMLTAVGV--LFTLTAVTAFDSLTVAMATMVGLGVGIDYAMFIVSRFREELTHHTGPDHAAIsgav 299
Cdd:pfam03176 165 SVVAALLPLLTVGLSLGAAQGLvaILAHILGIGLSTFALNLLVVLLIAVGTDYALFLVSRYREELRAGEDREEAVI---- 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  300 gRSLATAGKTILVSGLVVMISLCALIIIQAPIFRG----IAIGVATAVTSMLTVAvtllPALLaalgpavnrgSLPARWR 375
Cdd:pfam03176 241 -RAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQvgptIAIGVLVDVLAALTLL----PALL----------ALLGRWG 305

                         330       340       350
                  ....*....|....*....|....*....|
gi 748736234  376 PADSatdAPGVLGGRWARWAYLVMRRPVLF 405
Cdd:pfam03176 306 LWPP---KRDRTARWWRRIGRLVVRRPAPV 332
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 39-502 1.02e-21

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 100.81  E-value: 1.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234   39 VLAVWGLLLVVCAVAYPLLENRLGAMD---FGVEGSESTEVDRLVARHFPQFGTEQAVIVLQSGAVTATDAE--FRAAVA 113
Cdd:TIGR00833   6 IIGVWIATAISLQLLAPLLEDVSYFRLqaeLPGGAASSIAVKEMSAAFQEAIRDPKIILVLESNERLGDKDYatYDALIA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  114 RTITAATAVEGVVDVVGPYDGLPGSQiSADGH---VAIALAGMDGDMAERAKVARDLQDAIATTGDDSIDVGVTGYSAVQ 190
Cdd:TIGR00833  86 KLRADIMHVISVVDFWGPPEAAEGLR-SDDGKatiIIVNLAGEKGQKEAQEAINAVRRIVEQTNAPDGLTVHVTGPLATI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  191 NAATELQNADLARAEAIGIPVALVLLVLALGALAAAAVPIAVAIAGMLTAVGVLFTL--TAVTAFDSLTVAMATMVGLGV 268
Cdd:TIGR00833 165 ADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVSLLgiPGLIGVNAQTTVLLTALVIGA 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  269 GIDYAMFIVSRFREELTHHTGPDHaaisgAVGRSLATAGKTILVSGLVVMISLCALIIIQAPIFRG----IAIGVATAVT 344
Cdd:TIGR00833 245 GTDYAVFLTGRYHEERRKGESLEE-----AAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKTlgvsCAVGVLVALL 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  345 SMLTVavtllpaLLAALGPAVNRGSLPARwrpadsatdAPGVLGGRWARWAYLVMRRP--VLFGTAAAAVLVLAALPvfG 422
Cdd:TIGR00833 320 NAVTL-------TPALLTLEGREGLMKPG---------RKSKIRFIWRRLGTAVVRRPwpILVTTLIISGVSLLALP--L 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  423 IRYGLDMGTTALDDTPTGRASTALNTNFPPGALSPVEIIATGPSDTPLTADAeARVNRFLTEIDGDARIDTVLPAQLNDG 502
Cdd:TIGR00833 382 IRTGYDDEKMIPTDLESVQGYEAADRHFPGNSMDPMVVMIKSDHDVRNPALL-ADIDRFEREIKAVPGINMVQETQRPDG 460
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 435-734 1.40e-20

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 93.51  E-value: 1.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  435 DDTPTGRASTALNTNFPPGALSPVEIIATGPSDTPLT-ADAEARVNRFLTEIDGDARIDTVLPAQLNDGRMLAMAIPS-- 511
Cdd:pfam03176   5 ADAPSVRAMDRLGAAFPQADSDPIIVVVLGEGDQALGdAAAEAGYDTLVDALRADTGHVGSVQDFWGDPDTAALFVSPdg 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  512 ------VTFDSMAATDL----VRDLRNTAAGA---AGAEIRIGGSTAEFVDLSDemTTKLPLVVALVLTASLVFLIAA-- 576
Cdd:pfam03176  85 kaayvvVTLEGDPGTTEadesVAAVRDAVEQApppEGLKAYLTGPAATVADLRD--AGDRDLGLIEAVTLVVIFIILLiv 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  577 FRSIALPLKAIAMNLLATGAALGItVAVFQWGLGENVLDFTspgfvqvylPTVVFALLFGLSMDYEVFLIRRIREYWDAS 656
Cdd:pfam03176 163 YRSVVAALLPLLTVGLSLGAAQGL-VAILAHILGIGLSTFA---------LNLLVVLLIAVGTDYALFLVSRYREELRAG 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 748736234  657 GDNQRAVAAGLTHTARPITAAAAIMIAIFASFLTADILELKQLGLALAVAVAIDaVLIRLVLVPALMRLLGGWNWWLP 734
Cdd:pfam03176 233 EDREEAVIRAVRGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVD-VLAALTLLPALLALLGRWGLWPP 309
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 434-750 9.80e-20

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 94.06  E-value: 9.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 434 LDDTPTGRASTALNTNFPPGALSPVEIIATGPSDTPLTADAEARVNRFLTEIDGDARIDTVL--------PAQLNDGRML 505
Cdd:COG2409   37 LPGSESQRAADLLAEAFPESDGASAVVVVEAPDGTLTDPAFRAAVAALVARLRADPGVAGVQdpwddpaaGLVSEDGKAA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 506 AMAIPSVTFDSMAATDLVRDLRNTAAGA--AGAEIRIGGSTAEFVDLSDEMTTKLPLVVALVLTASLVFLIAAFRSIALP 583
Cdd:COG2409  117 LVTVTLDGDAGDEAAEAVDALRDAVAAApaPGLTVYVTGPAALAADLNEAFEEDLGRAELITLPVALVVLLLVFRSLVAA 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 584 LkaiaMNLLATGAALGITVAVFqWGLGENVLdftspgfVQVYLPTVVFALLFGLSMDYEVFLIRRIREYWDASGDNQRAV 663
Cdd:COG2409  197 L----LPLLTAGLAVGVALGLL-ALLAAFTD-------VSSFAPNLLTMLGLGVGIDYALFLVSRYREELRAGEDREEAV 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 664 AAGLTHTARPITAAAAIMIAIFASFLTADILELKQLGLALAVAVAIdAVLIRLVLVPALMRLLGGWNWWLPALRFRPPNT 743
Cdd:COG2409  265 ARAVATAGRAVLFSGLTVAIALLGLLLAGLPFLRSMGPAAAIGVAV-AVLAALTLLPALLALLGRRVFWPRRPRRRRAAA 343


                 ....*..
gi 748736234 744 RAPRAAA 750
Cdd:COG2409  344 PESGFWR 350
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 516-732 2.76e-16

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 83.48  E-value: 2.76e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  516 SMAATDLVRDLRNTAAGAA------GAEIRIGGSTAEFVDLSDEMTTKLPLVValVLTASLVFLIAA--FRSIALPLKAI 587
Cdd:TIGR00833 698 GDQGAQEFNAIRTVAEEAIqradlePAKVELAGVSAVNRDLRDLVNSDLGLIS--IITLAIVFMILAllLRAPVAPIVLI 775

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  588 AMNLLATGAALGITVAVFQWGLGENVldftspgfvQVYLPTVVFALLFGLSMDYEVFLIRRIREywDASGDNQRAVAAGL 667
Cdd:TIGR00833 776 GSVALSYLWALGLSVLAFQHILGAEL---------HWSVLAGVFVLLVALGVDYNMLLVSRIKE--ESPAGNRTGIIRAL 844

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 748736234  668 THTARPITAAAAIMIAIFASFLTADILELKQLGLALAVAVAIDAVLIRLVLVPALMRLLGGWNWW 732
Cdd:TIGR00833 845 GSTGGVITAAGLVFAGTMAALASAQLTAIAQFGFTVGVGILLDTFIVRSVTVPALTLLLGRWIWW 909
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
500-731 4.27e-15

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 79.52  E-value: 4.27e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 500 NDGRMLAMAI---PSVTFDSMAATDLVRDLRNTAA--GAAGAEIRIGGSTAEFVDLSDEMTTKLPLVVALVLTASLVFLI 574
Cdd:COG1033  157 PDGKATLIVVtldPDPLSSDLDRKEVVAEIRAIIAkyEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFPLALLLILLLLF 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 575 AAFRSIalplKAIAMNLLATGAALGITVAVFQWgLGENVLDFTSpgfvqvylptVVFALLFGLSMDYEVFLIRRIREYWD 654
Cdd:COG1033  237 LFFRSL----RGVLLPLLVVLLAVIWTLGLMGL-LGIPLSPLTI----------LVPPLLLAIGIDYGIHLLNRYREERR 301

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 748736234 655 ASGDNQRAVAAGLTHTARPITAAAAIMIAIFASFLTADILELKQLGLALAVAVAIdAVLIRLVLVPALMRLLGGWNW 731
Cdd:COG1033  302 KGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLL-AFLTSLTLLPALLSLLPRPKP 377
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 26-343 1.50e-14

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 77.50  E-value: 1.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  26 YRWGVLMARRRRAVLAVWGLLLVVCAVayPLLENRLGAMDFGV--EGSESTEVDRLVARHFPQFGTEQAVIVLQSGavTA 103
Cdd:COG2409  350 RRLARAVVRRPVPVLVAAVAVLLALAL--PALGLRLGLPDADSlpADSPSRQGYDALAEHFPPGSNGPLTVVVESD--DD 425

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 104 TDAEFRAAVARTITAATAVEGVVDVVGPYDGLpgsqiSADGHVAIALAGMDGD-MAERAK-VARDLQDAIATTGDDSiDV 181
Cdd:COG2409  426 LDPADLAALDALAAALAAVPGVASVQPPTRPE-----GTDGDAARLQVVPDGDpDSPEAIdLVDRLRDAAAPALEGA-EV 499

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 182 GVTGYSAVQNAATELQNADLARA----------------EAIGIPvalvllvlalgalaaaavpiavaiagMLTAVGVLF 245
Cdd:COG2409  500 LVGGTTAVNIDISDALADDLPLVipvvlglifllllllfRSVVAP--------------------------LKAVLTNLL 553

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 246 TLTA---VTAF----------------DSLTVAMATMVGLGVGIDYAMFIVSRFREELTHHTGPDHAAISGavgrsLATA 306
Cdd:COG2409  554 SLGAalgVLVLvfqhgwlllgftpgplDSFVPLLLFVILFGLGMDYEVFLVSRIREEYDRGGGTREAVIRG-----LART 628

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 748736234 307 GKTILVSGLVVMISLCALIIIQAPIFRGIAIGVATAV 343
Cdd:COG2409  629 GRVITSAALIMAAVFAAFATSPLVFLKQIGFGLAVGV 665
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 28-349 9.25e-12

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 68.71  E-value: 9.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234   28 WGVLMARRRRAVLAVWGLLLVVCAVAYpllenrlGAMDFGVE-------GSESTEVDRL--VARHFPQFGTEQAVIVLQS 98
Cdd:TIGR00921 373 SKVLSITVRHPVPALVAALIITGLGLY-------GAAGIKPEvniekfiPQDLPSLQARkvIESHMGGSHDFATILVKAD 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234   99 GAVTATDAEF---------RAAVARTITAATAVEGVVDVVG---PYDGLPGSQISAD--------GHVAIALAGMDGDMA 158
Cdd:TIGR00921 446 DVRDPELVRFmdelsrdikATGVAARVFGAPSIIDLVKEVEglpAPERSALEPIPEDeeggyisgGQIKVAVIQVQLKQG 525

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  159 E----RAKVARDLQDAIATTGddsIDVGVTGYSAVQNAATELQNADLARAEAIGIPVALVLLVLALGALAAAAVPIAVAI 234
Cdd:TIGR00921 526 EpkvqGRKILRDVQHEHPPPG---VKVGVTGLPVAFAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIG 602

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  235 AGMLTAVGVLFTltAVTAFDSLTVAMATMVgLGVGIDYAMFIVSRFREELTHHTGPDhaaisgAVGRSLATAGKTILVSG 314
Cdd:TIGR00921 603 SGILWAIGLMGL--RGIPSFLAMATTISII-LGLGMDYSIHLAERYFEERKEHGPKE------AITHTMERTGPGILFSG 673

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 748736234  315 LVVMISLCALIIIQAPIFRGI----AIGVATAVTSMLTV 349
Cdd:TIGR00921 674 LTTAGGFLSLLLSHFPIMRNFglvqGIGVLSSLTAALVV 712
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
24-348 1.97e-10

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 64.11  E-value: 1.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  24 VLYRWGVLMARRRRAVLAVWGLLLVVCAVAYPLLE---NRLGAMDfgvEGSESTEVDRLVARHFPqfGTEQAVIVLQSGA 100
Cdd:COG1033  391 LLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKveyDFEDYLP---EDSPIRQDLDFIEENFG--GSDPLEVVVDTGE 465

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 101 VTA-TDAEFRAAVARTITAATAVEGVVDVVGP-----------------YDGLPGSQ---------------------IS 141
Cdd:COG1033  466 PDGlKDPEVLKEIDRLQDYLESLPEVGKVLSLadlvkelnqalnegdpkYYALPESRellaqlllllssppgddlsrfVD 545

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 142 ADGHVAIALAGM-DGDMAERAKVARDLQDAIAT-TGDDSIDVGVTGYSAVQNAATELQNADLARAEAIGIpvalvllvla 219
Cdd:COG1033  546 EDYSAARVTVRLkDLDSEEIKALVEEVRAFLAEnFPPDGVEVTLTGSAVLFAAINESVIESQIRSLLLAL---------- 615

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234 220 LGALAAAAVPIAVAIAGMLTAVGVLFTLTAVTAF-----DSLTVAMATM--VGLGVGIDYAMFIVSRFREELTHHTGPDH 292
Cdd:COG1033  616 LLIFLLLLLAFRSLRLGLISLIPNLLPILLTFGLmgllgIPLNIATAVVasIALGIGVDYTIHFLSRYREERRKGGDLEE 695

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 748736234 293 aaisgAVGRSLATAGKTILVSGLVVMISLCALIIIQAPIFRGIAIGVA-TAVTSMLT 348
Cdd:COG1033  696 -----AIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLAlGLLVALLA 747
HpnN TIGR03480
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ...
 496-726 9.89e-10

hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.


Pssm-ID: 274598 [Multi-domain]  Cd Length: 862  Bit Score: 61.94  E-value: 9.89e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  496 PAQLNDGRMLAMAIPSVTFDSMA-ATDLVRDLRNTA-----AGAAGAEIRIGGSTA----EFVDLSDEMTTKLPLVVALV 565
Cdd:TIGR03480 203 DAALAPRRRFIIVQPVLDYSSLEpAEKAINAIRAAAkdlrlDEDHGVTVRLTGEVAlsdeELATVSEGATVAGLLSFVLV 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  566 LtaslVFLIAAFRSIALplkaIAMNLLATGAALGITVAVFQWGLGenvldftspgfvQVYLPTVVFALLF-GLSMDYEVF 644
Cdd:TIGR03480 283 L----VLLWLALRSPRL----VFAVLVTLIVGLILTAAFATLAVG------------HLNLISVAFAVLFiGLGVDFAIQ 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  645 LIRRIREYWDASGDNQRAVAAGLTHTARPITAAAAIMIAIFASFLTADILELKQLGLALAVAVAIdAVLIRLVLVPALMR 724
Cdd:TIGR03480 343 FSLRYREERFRGGNHREALSVAARRMGAALLLAALATAAGFFAFLPTDYKGVSELGIIAGTGMFI-ALFVTLTVLPALLR 421


                  ..
gi 748736234  725 LL 726
Cdd:TIGR03480 422 LL 423
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 138-339 5.86e-07

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 53.05  E-value: 5.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  138 SQISADGHVAIALAGMDGDMAERAKVARdlQDAIATTGDDSID--------VGVTGYSAVQNAATELQNADLARAEAIGI 209
Cdd:TIGR00833 677 YFLSPDGHAARLLVYGDGSPAGDQGAQE--FNAIRTVAEEAIQradlepakVELAGVSAVNRDLRDLVNSDLGLISIITL 754

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  210 PVALVLLVLALGALAAAAVPIAVAIAGMLTAVG---VLFTLTAVTAFDSLTVAMATMVGLGVGIDYAMFIVSRFREELTH 286
Cdd:TIGR00833 755 AIVFMILALLLRAPVAPIVLIGSVALSYLWALGlsvLAFQHILGAELHWSVLAGVFVLLVALGVDYNMLLVSRIKEESPA 834

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 748736234  287 htGPDHAAIsgavgRSLATAGKTILVSGLVVMISLCALIIIQ----APIFRGIAIGV 339
Cdd:TIGR00833 835 --GNRTGII-----RALGSTGGVITAAGLVFAGTMAALASAQltaiAQFGFTVGVGI 884
actII TIGR00833
Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family ...
 541-734 1.58e-06

Transport protein; The Resistance-Nodulation-Cell Division (RND) Superfamily- MmpL sub family (TC 2.A.6.5)Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. This sub-family includes the S. coelicolor ActII3 protein, which may play a role in drug resistance, and the M. tuberculosis MmpL7 protein, which catalyzes export of an outer membrane lipid, phthiocerol dimycocerosate. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 129913 [Multi-domain]  Cd Length: 910  Bit Score: 51.89  E-value: 1.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  541 GGSTAEFVDLSDEMTTKLPLVVALVLTASLVFLIAAFRSIALPLKAIAMNLLATGAALGitvavfqwGLGEnvldftsPG 620
Cdd:TIGR00833 161 LATIADILESGDKDMNRITATTGIIVLIILLLVYRSPITMLVPLVSVGFSVVVAQGIVS--------LLGI-------PG 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  621 FVQVYLPTVVF--ALLFGLSMDYEVFLIRRIREYWDASGDNQRAVAAGLTHTARPITAAAAIMIAIFASFLTADILELKQ 698
Cdd:TIGR00833 226 LIGVNAQTTVLltALVIGAGTDYAVFLTGRYHEERRKGESLEEAAAEALRGTGKAILGSALTVAVAFLALSLARLPSFKT 305

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 748736234  699 LGLALAVAVAIdAVLIRLVLVPALMRLLGGWNWWLP 734
Cdd:TIGR00833 306 LGVSCAVGVLV-ALLNAVTLTPALLTLEGREGLMKP 340
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 33-349 2.25e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.91  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234   33 ARRRRAVLAVWGLLLVVCAVAYPLLENRLGAMDFGVEGSESTEVDRLVARHFpQFGTEQAVIVLQsgAVTATDAEFRAAV 112
Cdd:TIGR00921   1 MRFRTAIILVFLALLILSAYGAQHLNVESDTEKQLPKDFESYKWYHVLQREF-GTSTKTLLVVIE--GDDVTRKPVLDYM 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  113 ARTITAATAVEGVVDVVGPYD---------GLPGSQ-----------------ISADGHVAIALAGMDGDMAERAKV--A 164
Cdd:TIGR00921  78 RRLEQRLREKPYVTNVRSAADimrqipgnfPLPVTMpevrplmseyprskemfLSKDHTVAIIIVQLKSDADYKQVVpiY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  165 RDLQDAIATTGDDS-IDVGVTGYSAVQNAATELQNADLARAEAIGIPVALVLLVLALGALAAAAVPIAVAIAGMLTAVGV 243
Cdd:TIGR00921 158 NDVERSLERTNPPSgKFLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGI 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  244 LFTLTAvtAFDSLTVAMATMVgLGVGIDYAMFIVSRFREEltHHTGPDhaaISGAVGRSLATAGKTILVSGLVVMISLCA 323
Cdd:TIGR00921 238 MGWLGI--PLYATTLLAVPML-IGVGIDYGIQTLNRYEEE--RDIGRA---KGEAIVTAVRRTGRAVLIALLTTSAGFAA 309

                         330       340       350
                  ....*....|....*....|....*....|
gi 748736234  324 LIIIQAPIFR----GIAIGVATAVTSMLTV 349
Cdd:TIGR00921 310 LALSEFPMVSefglGLVAGLITAYLLTLLV 339
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 535-730 1.49e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 45.21  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  535 GAEIRIGGSTAEFVDLSDEMTTKLPLVVALVLTASLVFLIAAFRSI---ALPLKAIAMNLLATGAALGItvavfqwgLGE 611
Cdd:TIGR00921 172 GKFLDVTGSPAINYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWwrpLLPLVIILFGVAWVLGIMGW--------LGI 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 748736234  612 NvLDFTSpgfvqvylpTVVFALLFGLSMDYEVFLIRRIREYWDASGDNQRAVAAGLTHTARPITAAAAIMIAIFASFLTA 691
Cdd:TIGR00921 244 P-LYATT---------LLAVPMLIGVGIDYGIQTLNRYEEERDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALS 313

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 748736234  692 DILELKQLGLALAVAVaIDAVLIRLVLVPALMRLLGGWN 730
Cdd:TIGR00921 314 EFPMVSEFGLGLVAGL-ITAYLLTLLVLPALLQSIDIGR 351
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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