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Conserved domains on  [gi|748726692|ref|WP_039984810|]
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helix-turn-helix transcriptional regulator [Fusobacterium periodonticum]

Protein Classification

helix-turn-helix transcriptional regulator( domain architecture ID 10787697)

helix-turn-helix (HTH) transcriptional regulator containing a XRE (Xenobiotic Response Element) family HTH domain may act as a transcriptional regulator that controls the expression of genes involved in stress response

CATH:  1.10.10.10
Gene Ontology:  GO:0003677
PubMed:  10473770|2644244
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-61 4.32e-13

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


:

Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 57.17  E-value: 4.32e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 748726692  1 MTIGEKLKKLRGNKR--QTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEIFF 61
Cdd:COG1476   3 KKLGNRLKELRKERGltQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFS 65
 
Name Accession Description Interval E-value
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-61 4.32e-13

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 57.17  E-value: 4.32e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 748726692  1 MTIGEKLKKLRGNKR--QTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEIFF 61
Cdd:COG1476   3 KKLGNRLKELRKERGltQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFS 65
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 4-59 3.72e-11

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 51.78  E-value: 3.72e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 748726692  4 GEKLKKLRGNKR--QTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEI 59
Cdd:cd00093   1 GERLKELRKEKGltQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
6-59 9.14e-10

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 48.28  E-value: 9.14e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 748726692    6 KLKKLRGNK--RQTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEI 59
Cdd:smart00530  1 RLKELREEKglTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 7-59 2.69e-09

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 47.15  E-value: 2.69e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 748726692   7 LKKLR--GNKRQTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEI 59
Cdd:pfam01381  1 LKELReeLGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
 
Name Accession Description Interval E-value
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
1-61 4.32e-13

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 57.17  E-value: 4.32e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 748726692  1 MTIGEKLKKLRGNKR--QTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEIFF 61
Cdd:COG1476   3 KKLGNRLKELRKERGltQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELFS 65
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
1-60 4.71e-13

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 57.31  E-value: 4.71e-13
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 748726692  1 MTIGEKLKKLRGNK--RQTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEIF 60
Cdd:COG1396   6 KALGERLRELRKARglTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELL 67
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 4-59 3.72e-11

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 51.78  E-value: 3.72e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 748726692  4 GEKLKKLRGNKR--QTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEI 59
Cdd:cd00093   1 GERLKELRKEKGltQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
6-59 9.14e-10

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 48.28  E-value: 9.14e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 748726692    6 KLKKLRGNK--RQTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEI 59
Cdd:smart00530  1 RLKELREEKglTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 7-59 2.69e-09

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 47.15  E-value: 2.69e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 748726692   7 LKKLR--GNKRQTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEI 59
Cdd:pfam01381  1 LKELReeLGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 4-60 8.34e-08

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 43.43  E-value: 8.34e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 748726692   4 GEKLKKLRGNKR--QTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDEIF 60
Cdd:pfam12844  1 GERLRKAREERGltQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLL 59
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 2-58 2.16e-05

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 37.61  E-value: 2.16e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 748726692  2 TIGEKLKKLRGNKR--QTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKKTVDE 58
Cdd:COG1813  12 DYGERIREAREARGlsQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISLAE 70
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
4-54 9.84e-03

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 30.67  E-value: 9.84e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 748726692  4 GEKLKKLRgnKR----QTEIAKDLGILPSAYSNYENNYRIPNDETKKKIANYYKK 54
Cdd:COG2944   8 PEEIRALR--ERlglsQAEFAALLGVSVSTVRRWEQGRRKPSGAALKLLRLLEKH 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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