|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
10-374 |
1.53e-75 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 238.70 E-value: 1.53e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 10 RLATRLAFLVAGFGIACWAPLVPFAKTRLGVDDGVLGLLLLSLGIGSVVAMLLTGVMSARYGSKPIIIAGGLGLALVLPL 89
Cdd:cd17393 1 RLAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 90 LAIASSPATLALALFAFGAALGSIDVAMNIHAVEVERDAGRPLMSGFHALFSIGGFAGSALMTALLSLQLGALACTLICS 169
Cdd:cd17393 81 LGLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 170 VLMLVAMLAAWPRLLRSVQVQD--------GPLFVLPHGSVLLLALLGAITFLVEGAMLDWGALLVIGAGLVSEAQGGIG 241
Cdd:cd17393 161 VLLLLAALVAIRALLPGTGEAAedrpdgagKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 242 YIVFSIAMTAGRLGGDAVVARIGDRATLFWGSIIAIAGFVVLLRAPVAAVAIGGFLLIGLGASNLVPVLFRRAARQTVMP 321
Cdd:cd17393 241 YAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 742504969 322 TGLAVAAITTAGYAGILIGPAGVGFVARLGGLPTAFWLLAALMCLVALSARIV 374
Cdd:cd17393 321 AGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-374 |
1.43e-43 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 155.78 E-value: 1.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 1 MHSADRPATRLATRLAFLVAGFGIACWAPLVPFAKTRLGVDDGVLGLLLLSLGIGSVVAMLLTGVMSARYGSKPIIIAGG 80
Cdd:COG0738 1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 81 LGLALVLPLLAIASSPATLALALFAFGAALGSIDVAMNIHAVEVERDAGRPLMSGFHALFSIGGFAGSALMTALLSLQLG 160
Cdd:COG0738 81 LLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 161 ALACT--LICSVLMLVAMLAAWPRLLRSVQVQD--------GPLFVLPHGSVLLLALLGAITFLVEGAMLDWGALLVIGA 230
Cdd:COG0738 161 LSWHLpyLILAVLLLLLALLFLRSKLPEIEEEEeeaagsaaSLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 231 GLVSEAQGGIGYIVFSIAMTAGRLGGDAVVARIGDRATLFWGSIIAIAGFVVLLRAPVAAVAIGGFLLIGLGASNLVPVL 310
Cdd:COG0738 241 LGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTI 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 742504969 311 FRRAARQTVMPTGLAVAAITTAGYAGILIGPAGVGFVARLGGLPTAFWLLAALMCLVALSARIV 374
Cdd:COG0738 321 FSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
15-373 |
1.70e-20 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 91.61 E-value: 1.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 15 LAFLVAGFGIACWAPLVPFAKTRLGVDDGVLGLLLLSLGIGSVVAMLLTGVMSARYGSKPIIIAGGLGLALVLPLLAIAS 94
Cdd:cd17333 3 ISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 95 SPATLALALFAFGAALGSIDVAMNIHAVEVERDAGRPLMSGFHALFSIGGFAGSALMTALL----SLQLGALACTLICSV 170
Cdd:cd17333 83 SIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLtselSWSWAYLIIGLIYLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 171 LMLVAMLAAWPRLLRSVQVQDGPLFVLPHGS-------VLLLALLGAITFLVEGAMLDWGALLVIGAGLVSEAQGGIGYI 243
Cdd:cd17333 163 LAILILLTLFPELPSARNPQQSVGAFSASASrllrnpsIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLS 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 244 VFSIAMTAGRLGGDAVVARIGDRATLFWGSIIAIAGFVVLLRAPVAAVAIGGFLLIGLGASNLVPVLFRRAARQTVMPTG 323
Cdd:cd17333 243 GFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKG 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 742504969 324 LAVAAITTAGYAGILIGPAGVGFVARLGGLPTAFWLLAALMCLVALSARI 373
Cdd:cd17333 323 KGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
15-369 |
2.61e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 61.44 E-value: 2.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 15 LAFLVAGFGIACWAPLVPFAKTRLGVDDGVLGLLLLSLGIGSVVAMLLTGVMSARYGSKPIIIAGGLGLALVLPLLAIAS 94
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 95 SPATLALALFAFGAALGSIDVAMNIHAVEVERDAGRPLMSGFHALFSIGGFAGSALMTALLSLQLGALACTLICSVLMLV 174
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 175 AMLAAW-----------PRLLRSVQVQDGPLFVLPHGSVLLLALLGAITFLVEGAMLDWGALLVIGAGLVSEAQGGIGYI 243
Cdd:cd17325 163 ALVLALlllpeprpppnKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 244 VFSIAMTAGRLGGDAVVARIGDRATLFWGSIIAIAGFVVLLRAPVAAVAIGGFLLIGLGASNLVPVLFRRAARQT-VMPT 322
Cdd:cd17325 243 AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVpPEGR 322
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 742504969 323 GLAVAAITTAGYAGILIGPAGVGFVARLGGLPTAFWLLAALMCLVAL 369
Cdd:cd17325 323 GTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAV 369
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-318 |
1.75e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.75 E-value: 1.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 15 LAFLVAGFGIACWAPLVPFAKTRLGVDDGVLGLLLLSLGIGSVVAMLLTGVMSARYGSKPIIIAGGLGLALVLPLLAIAS 94
Cdd:COG2814 17 LGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 95 SPATLALALFAFGAALGSIDVAMNIHAVEVERDAGRPLMSGFHALFSIGGFAGSALMTALLSLQLGALACTLICSVLMLV 174
Cdd:COG2814 97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 175 AMLAAWPRLLRSVQVQDGPLF-----VLPHGSVLLLALLGAITFLVEGAMLDWGALLVIGAGLVSEAQGGIGYIVFSIAM 249
Cdd:COG2814 177 ALLLLLRLLPESRPAARARLRgslreLLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGG 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 742504969 250 TAGRLGGDAVVARIGDRATLFWGSIIAIAGFVVLLRAPVAAVAIGGFLLIGLGASNLVPVLFRRAARQT 318
Cdd:COG2814 257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA 325
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
197-368 |
4.91e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 4.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 197 LPHGSVLLLALLGAITFLVEGAMLDWGALLVIGAGLVSEAQGGIGYIVFSIAMTAGRLGGDAVVARIGDRATLFWGSIIA 276
Cdd:cd17473 194 LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALM 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 277 IAGFVVLLRAPVAAVAIGGFLLIGLGASNLVPVLFRRAARQT-VMPTGLAVAAITTAGYAGILIGPAGVGFVARLGGLPT 355
Cdd:cd17473 274 ALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVpPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLS 353
|
170
....*....|...
gi 742504969 356 AFWLLAALMCLVA 368
Cdd:cd17473 354 GAFLILGVLALVL 366
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
15-380 |
3.57e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.79 E-value: 3.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 15 LAFLVAGFGIACWAPLVPFAKTRLGVDDGVLGLLLLSLGIGSVVAMLLTGVMSARYGSKPIIIAGGLGLALVLPLLAIAS 94
Cdd:COG2271 17 LAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 95 SPATLALALFAFGAALGSIDVAMNIHAVEVERDAGRPLMSGFHALFSIGGFAGSALMTALLSLQLGALACTLICSVLMLV 174
Cdd:COG2271 97 SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLL 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 175 AMLAAwprllrsvqvqdgplfvlphgsVLLLALLGAITFLVEGAMLDWGALLVIGAGLVSEAQGGIGYIVFSIAMTAGRL 254
Cdd:COG2271 177 LALLR----------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 255 GGDAVVARIGDR--ATLFWGSIIAIAGFVVLLRAPVAAVAIGGFLLIGLGASNLVPVLFrrAARQTVMPT---GLAVAAI 329
Cdd:COG2271 235 LGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLW--ALAAELFPKkarGTASGLV 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 742504969 330 TTAGYAGILIGPAGVGFVARLGGLPTAFWLLAALMCLVALSARIVTAEGRQ 380
Cdd:COG2271 313 NTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
15-369 |
1.05e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.12 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 15 LAFLVAGFGIACWAPLVPFAKTRLGVDDGVLGLLLLSLGIGSVVAMLLTGVMSARYGSKPIIIAGGLGLALVLPLLAIAS 94
Cdd:cd06174 3 LGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 95 SPATLALALFAFGAALGSIDVAMNIHAVEVERDAGRPLMSGFHALFS-----IGGFAGSALMTALLSLQLGALACTLICS 169
Cdd:cd06174 83 SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGsvggiLGPLLGGILASSLGFGWRAVFLIAAALA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 170 VLMLVAMLAAWPRLLRSVQVQDGPLF----------VLPHGSVLLLALLGAITFLVEGAMLDWGALLVIGAGLVSEAQGG 239
Cdd:cd06174 163 LLAAILLLLVVPDPPESARAKNEEASsksvlkllkrVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 240 IGYIVFSIAMTAGRLGGDAVVARIGDRATLFWGSIIAIA-GFVVLLRAPVAAVAIGGFLLIGLGASNLVPVLFRRAARQT 318
Cdd:cd06174 243 LLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAlGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELF 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 742504969 319 -VMPTGLAVAAITTAGYAGILIGPAGVGFVARLGGLPTAFWLLAALMCLVAL 369
Cdd:cd06174 323 pPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAA 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
57-371 |
1.67e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.47 E-value: 1.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 57 VVAMLLTGVMSARYGSKPIIIAGGLGLALVLPLLAIASSPATLALALFAFGAALGSI-DVAMNIHAVEVERDAGRPLMSG 135
Cdd:cd17324 48 ALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYAADLVPPEKRGRAIGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 136 FHALFSIGGFAGSALMTaLLSLQLGALACTLICSVLMLVAMLAAWPRLLRSVQVQDGPLF-------VLPHGSVLLLALL 208
Cdd:cd17324 128 VFSGLTLGLVLGRPLGG-LLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGllsslllLLRNPRLRLAYLI 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 209 GAITFLVEGAMLDWGALLVIGAGLVSEAQGGIGYIVFSIAMTAGRLGGDAVVARIGDRATLFWGSIIAIAGFVVLLRAPV 288
Cdd:cd17324 207 TFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPS 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 289 AAVAIGGFLLIGLGASNLVPVLFRRAARQTVMPTGLAVAAITTAGYAGILIGPAGVGFVARLGGLPTAFWLLAALMCLVA 368
Cdd:cd17324 287 PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366
|
...
gi 742504969 369 LSA 371
Cdd:cd17324 367 LLA 369
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
15-369 |
3.88e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.33 E-value: 3.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 15 LAFLVAGFGIACWAPLVPFAKTRLGVDDGVLGLLLLSLGIGSVVAMLLTGVMSARYGSKPIIIAGGLGLALVLPLLAIAS 94
Cdd:COG2807 25 LVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 95 SPATLALALFAFGAALGSIDVAMNIhAVEVERDAGRPLMSGFHALFSIGGFAGSALMTALLSLQLGALACTLICSVLMLV 174
Cdd:COG2807 105 SVALLLAGTALIGAGIAVGNVLLPG-LIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 175 AMLAAWPRLLRSVQVQDGPLFVLPHGSVL------LLALLGAITFLVEGAMLDWGALLVIGAGLvSEAQGGIGYIVFSIA 248
Cdd:COG2807 184 ALLLWLPLLRRRPAAAAAAPAAASLRSLWrsplawLLTLFFGLQSLLYYAVVAWLPPILRDAGL-SAATAGLLLSLFQLA 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 249 MTAGRLGGDAVVARIGDRATLFWG-SIIAIAGFVVLLRAPVAAVAIGGFLL-IGLGASN-LVPVLFRRAARqTVMPTGLA 325
Cdd:COG2807 263 GIPGSLLVPLLADRLGDRRPLLLLlGLLGLAGLLGLLLAPGSLPWLWAVLLgLGQGGLFpLALTLIGLRAR-TPAEAAAL 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 742504969 326 VAAITTAGYAGILIGPAGVGFVARLGGLPTAFWLLAALMCLVAL 369
Cdd:COG2807 342 SGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLML 385
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-369 |
6.25e-06 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 47.95 E-value: 6.25e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 15 LAFLVAGFGIACWAPLVPFAKTRLGVDDGVLGLLLLSLGIGSVVAMLLTGVMSARYGSKPIIIAGGLGLALVLPLLAIAS 94
Cdd:COG2223 12 LAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 95 SPATLALALFAFGAALGSIDVAMNIHAVEVERDAGRPLMSGFHALFSIGGFAGSALMTALLSLQLGALACTLICSVLMLV 174
Cdd:COG2223 92 SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 175 AMLAAWPRLLRSVQVQDGP--------LFVLPHGSVLLLALLGAITFLVEGAMLDWGALLVIGAGLVSEAQGGIGYIVFS 246
Cdd:COG2223 172 VAVLAWLFLRDPPAGAAAAakaslrdqLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFA 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 247 IAMTAGRLGGDAVVARIGDRATLFWGSIIAIAGFVVLLRAP-------VAAVAIGGFLLIGLGA-SNLVPVLFRRAARqt 318
Cdd:COG2223 252 LLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALgslwlflVLFLLLGLALGGGNGAvFALVPDIFPTKNA-- 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 742504969 319 vmptGLAVAAITTAGYAGILIGPAGVGFVARLGGLPTAFWLLAALMCLVAL 369
Cdd:COG2223 330 ----GAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVAL 376
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
198-383 |
1.51e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 40.24 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 198 PHGSVLLLALLGAITFLVEGAMLDWGALL-VIGAGL-VSEAQGGIGYIVFSIAMTAGRLGGDAVVARIGDRATLFWGSII 275
Cdd:COG2807 13 RAGRWLLLLAIVLVALNLRPAITSVGPLLpEIRADLgLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 276 AIAGFVVLLRAPVAAVAIGGFLLIGLG---ASNLVPVLFRRAARQTVmptGLAVAAITTAGYAGILIGPAGVGFVARLGG 352
Cdd:COG2807 93 LAAGLLLRSLAPSVALLLAGTALIGAGiavGNVLLPGLIKRWFPDRV---GLMTGLYTAAMGLGAALAAGLTVPLAAALG 169
|
170 180 190
....*....|....*....|....*....|.
gi 742504969 353 LPTAFWLLAALMCLVALSARIVTAEGRQTSR 383
Cdd:COG2807 170 WRGALAVWALLALLALLLWLPLLRRRPAAAA 200
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
138-369 |
1.64e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.29 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 138 ALFSIGGFAGSALMTALLSLqLGALACTLICSVLMLVAMLAAW------------PRLLRSVQVQDGPLFVLPHGSVLLL 205
Cdd:cd06173 135 LATQLARIIGPALGGLLVAL-LGPGGAFAINALSFLLSALLLLfirrpppaapgeSSSLLLRDLREGLRYLRRSPLLRLL 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 206 ALLGAITFLVEGAMLDWGALLVIGAGLVSEAQGGIGYIVFSIAMTAGRLGGDAVVARIGDRATLFWGSIIAIAGFVVLLR 285
Cdd:cd06173 214 LLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGL 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 286 APVAAVAIGGFLLIGLGASNLVPVLFrrAARQTVMPT---GLAVAAITTAGYAGILIGPAGVGFVARLGGLPTAFWLLAA 362
Cdd:cd06173 294 SPSLWLLLAALFLLGLAGGLFNVPLN--TLLQLRVPDelrGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGA 371
|
....*..
gi 742504969 363 LMCLVAL 369
Cdd:cd06173 372 LLLLAAL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
57-341 |
7.54e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.17 E-value: 7.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 57 VVAMLLTGVMSARYGSKPIIIAGGLGLALVLPLLAIASSPATLALALFAFGAALGSIDVAMNIHAVEVERDAGRPLMSGF 136
Cdd:pfam07690 46 ALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGL 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 137 HALFSIGGFAGSALMTALLSLQLGALACTLICSVLMLVAMLAAWPRLLRS-----------VQVQDGPLFVLPHGSVLLL 205
Cdd:pfam07690 126 VSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPeskrpkpaeeaRLSLIVAWKALLRDPVLWL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 206 ALLGAITFLVEGAMLDWGALLVIGAGLvSEAQGGIGYIVFSIAMTAGRLGGDAVVARIGDRATLFWGSIIAIAGFVVLLR 285
Cdd:pfam07690 206 LLALLLFGFAFFGLLTYLPLYQEVLGL-SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL 284
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 286 APVA---AVAIGGFLLIGLGASNLVPVLFRRAARQTVMP-TGLAVAAITTAGYAGILIGP 341
Cdd:pfam07690 285 LSLTlssLWLLLALLLLGFGFGLVFPALNALVSDLAPKEeRGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
198-383 |
8.28e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.03 E-value: 8.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 198 PHGSVLLLALLGAITFLVEGAMLdwGALLVIGAGL-VSEAQGGIGYIVFSIAMTAGRLGGDAVVARIGDRATLFWGSIIA 276
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVL--PALPLIAADLgASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742504969 277 IAGFVVLLRAPVAAVAIGGFLLIGLGASNLVPVLFRRAARQTVMPT-GLAVAAITTAGYAGILIGPAGVGFVARLGGLPT 355
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERrGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180
....*....|....*....|....*...
gi 742504969 356 AFWLLAALMCLVALSARIVTAEGRQTSR 383
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPESRPAAR 193
|
|
| |
