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Conserved domains on  [gi|742394559|ref|WP_038873684|]
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MULTISPECIES: XRE family transcriptional regulator [Serratia]

Protein Classification

XRE family transcriptional regulator( domain architecture ID 14364052)

XRE (Xenobiotic Response Element) family transcriptional regulator with a cupin effector domain, similar to Escherichia coli HTH-type transcriptional regulator SutR that is involved in sulfur utilization

Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  15808743|14697267

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
17-96 1.42e-16

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 71.18  E-value: 1.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559  17 TVSEAVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADIVNVTRAPAAYLIESQD 96
Cdd:COG1396    3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLSEE 82
COG3837 super family cl43961
Uncharacterized conserved protein, cupin superfamily [Function unknown];
104-191 4.01e-09

Uncharacterized conserved protein, cupin superfamily [Function unknown];


The actual alignment was detected with superfamily member COG3837:

Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 52.33  E-value: 4.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559 104 DRGGSARLLAGTRGPNMIELWRWEMAPGEAYASG-GHPAGTfELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRYA 182
Cdd:COG3837   11 EAGRRYRRLGDALGLTRLGVNLITLPPGASSSPYhAHSAEE-EFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPHRLR 89


                 ....*....
gi 742394559 183 NEGEDTLIF 191
Cdd:COG3837   90 NRGDEPARY 98
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
17-96 1.42e-16

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 71.18  E-value: 1.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559  17 TVSEAVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADIVNVTRAPAAYLIESQD 96
Cdd:COG1396    3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLSEE 82
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 23-80 3.54e-14

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 64.11  E-value: 3.54e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 742394559  23 SRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADI 80
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
25-80 7.49e-14

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 63.31  E-value: 7.49e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 742394559    25 RIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADI 80
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 26-80 3.63e-12

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 58.71  E-value: 3.63e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 742394559   26 IKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADI 80
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
104-191 4.01e-09

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 52.33  E-value: 4.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559 104 DRGGSARLLAGTRGPNMIELWRWEMAPGEAYASG-GHPAGTfELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRYA 182
Cdd:COG3837   11 EAGRRYRRLGDALGLTRLGVNLITLPPGASSSPYhAHSAEE-EFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPHRLR 89


                 ....*....
gi 742394559 183 NEGEDTLIF 191
Cdd:COG3837   90 NRGDEPARY 98
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 124-195 1.14e-08

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 49.95  E-value: 1.14e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 742394559  124 WRWEMAPGEAYASGGHPaGTFELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRYANEGEDTLIFTMTV 195
Cdd:pfam07883   1 GLVTLPPGESSPPHRHP-GEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRFRNTGDEPARLLDVY 71
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 106-195 2.14e-08

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 49.81  E-value: 2.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559 106 GGSARLLAGTRGPNMIELWRWEMAPG----EAYASGGHpagtfELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRY 181
Cdd:cd02209    1 GYTYELLSPGLPGRKMEPFLVTLPPGgsggEPYSHEGE-----EFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRY 75

                         90
                 ....*....|....
gi 742394559 182 ANEGEDTLIFTMTV 195
Cdd:cd02209   76 RNPGDEPARVLWVI 89
PRK09943 PRK09943
HTH-type transcriptional regulator PuuR;
18-183 9.39e-08

HTH-type transcriptional regulator PuuR;


Pssm-ID: 182158 [Multi-domain]  Cd Length: 185  Bit Score: 49.79  E-value: 9.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559  18 VSEAVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADIVNVTRAPAA--YLIESQ 95
Cdd:PRK09943   4 EGLAPGKRLSEIRQQQGLSQRRAAELSGLTHSAISTIEQDKVSPAISTLQKLLKVYGLSLSEFFSEPEKPDEpqVVINQD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559  96 DIPTLwhGDRGGSARLLagTRGPN------MIELWRWEMAPGEAYASGGHPAGTfellhVEQGVLSLTVEQTELRITPGC 169
Cdd:PRK09943  84 DLIEM--GSQGVSMKLV--HNGNPnrtlamIFETYQPGTTTGERIKHQGEEIGT-----VLEGEIVLTINGQDYHLVAGQ 154

                        170
                 ....*....|....
gi 742394559 170 SAVARTDGPHRYAN 183
Cdd:PRK09943 155 SYAINTGIPHSFSN 168
couple_hipB TIGR03070
transcriptional regulator, y4mF family; Members of this family belong to a clade of ...
 26-75 1.13e-05

transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions]


Pssm-ID: 213767 [Multi-domain]  Cd Length: 58  Bit Score: 41.49  E-value: 1.13e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 742394559   26 IKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGL 75
Cdd:TIGR03070   7 VRARRKALGLTQADLADLAGVGLRFIRDLENGKPTVRLDKVLRVLDALGL 56
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
17-96 1.42e-16

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 71.18  E-value: 1.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559  17 TVSEAVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADIVNVTRAPAAYLIESQD 96
Cdd:COG1396    3 TLKKALGERLRELRKARGLTQEELAERLGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGADEELPEALLSEE 82
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 23-80 3.54e-14

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 64.11  E-value: 3.54e-14
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 742394559  23 SRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADI 80
Cdd:cd00093    1 GERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
25-80 7.49e-14

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 63.31  E-value: 7.49e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 742394559    25 RIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADI 80
Cdd:smart00530   1 RLKELREEKGLTQEELAEKLGVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
19-81 1.66e-13

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 62.56  E-value: 1.66e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 742394559  19 SEAVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADIV 81
Cdd:COG1476    2 KKKLGNRLKELRKERGLTQEELAELLGVSRQTISAIENGKYNPSLELALKIARALGVSLEELF 64
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 26-80 3.63e-12

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 58.71  E-value: 3.63e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 742394559   26 IKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADI 80
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 17-79 2.47e-10

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 54.17  E-value: 2.47e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 742394559  17 TVSEAVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVAD 79
Cdd:COG1813    8 ELVEDYGERIREAREARGLSQEELAEKLGVSESTIRRIERGEATPSLDTLRKLEKALGISLAE 70
COG3837 COG3837
Uncharacterized conserved protein, cupin superfamily [Function unknown];
104-191 4.01e-09

Uncharacterized conserved protein, cupin superfamily [Function unknown];


Pssm-ID: 443048 [Multi-domain]  Cd Length: 115  Bit Score: 52.33  E-value: 4.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559 104 DRGGSARLLAGTRGPNMIELWRWEMAPGEAYASG-GHPAGTfELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRYA 182
Cdd:COG3837   11 EAGRRYRRLGDALGLTRLGVNLITLPPGASSSPYhAHSAEE-EFVYVLEGELTLRIGGEEYVLEPGDSVGFPAGVPHRLR 89


                 ....*....
gi 742394559 183 NEGEDTLIF 191
Cdd:COG3837   90 NRGDEPARY 98
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 124-195 1.14e-08

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 49.95  E-value: 1.14e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 742394559  124 WRWEMAPGEAYASGGHPaGTFELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRYANEGEDTLIFTMTV 195
Cdd:pfam07883   1 GLVTLPPGESSPPHRHP-GEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRFRNTGDEPARLLDVY 71
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 24-84 1.37e-08

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 49.59  E-value: 1.37e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 742394559   24 RRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADIVNVT 84
Cdd:pfam12844   2 ERLRKAREERGLTQEELAERLGISRSQLSAIENGKSVPPAETLYKIAELLGVPANWLLQGE 62
cupin_XRE_C cd02209
XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; ...
 106-195 2.14e-08

XRE (Xenobiotic Response Element) family transcriptional regulators, C-terminal cupin domain; This family contains transcriptional regulators containing an N-terminal XRE (Xenobiotic Response Element) family helix-turn-helix (HTH) DNA-binding domain and a C-terminal cupin domain. Included in this family is Escherichia coli transcription factor SutR (YdcN) that plays a regulatory role in sulfur utilization; it regulates a set of genes involved in the generation of sulfate and its reduction, the synthesis of cysteine, the synthesis of enzymes containing Fe-S as cofactors, and the modification of tRNA with use of sulfur-containing substrates. This family belongs to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380339 [Multi-domain]  Cd Length: 90  Bit Score: 49.81  E-value: 2.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559 106 GGSARLLAGTRGPNMIELWRWEMAPG----EAYASGGHpagtfELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRY 181
Cdd:cd02209    1 GYTYELLSPGLPGRKMEPFLVTLPPGgsggEPYSHEGE-----EFGYVLEGELELTVGGETYVLEAGDSIYFDSDVPHRY 75

                         90
                 ....*....|....
gi 742394559 182 ANEGEDTLIFTMTV 195
Cdd:cd02209   76 RNPGDEPARVLWVI 89
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 14-81 4.78e-08

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 48.86  E-value: 4.78e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559  14 DVQTVS--EAVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADIV 81
Cdd:COG3620    8 DVVTVSpdDTLGEALRLMRKELGLSQLPVAELVGVSQSDILRIESGKRDPTVSTLEKIAEALGKELSAVL 77
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
105-191 7.06e-08

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 48.69  E-value: 7.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559 105 RGGSARLLAgtRGPNMIELWRWEMAPGEAYASggHPAGTFELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRYANE 184
Cdd:COG1917    9 TGVSVRVLA--DGEDELEVVRVTFEPGARTPW--HSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPGVPHAFRNL 84


                 ....*..
gi 742394559 185 GEDTLIF 191
Cdd:COG1917   85 GDEPAVL 91
PRK09943 PRK09943
HTH-type transcriptional regulator PuuR;
18-183 9.39e-08

HTH-type transcriptional regulator PuuR;


Pssm-ID: 182158 [Multi-domain]  Cd Length: 185  Bit Score: 49.79  E-value: 9.39e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559  18 VSEAVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADIVNVTRAPAA--YLIESQ 95
Cdd:PRK09943   4 EGLAPGKRLSEIRQQQGLSQRRAAELSGLTHSAISTIEQDKVSPAISTLQKLLKVYGLSLSEFFSEPEKPDEpqVVINQD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559  96 DIPTLwhGDRGGSARLLagTRGPN------MIELWRWEMAPGEAYASGGHPAGTfellhVEQGVLSLTVEQTELRITPGC 169
Cdd:PRK09943  84 DLIEM--GSQGVSMKLV--HNGNPnrtlamIFETYQPGTTTGERIKHQGEEIGT-----VLEGEIVLTINGQDYHLVAGQ 154

                        170
                 ....*....|....
gi 742394559 170 SAVARTDGPHRYAN 183
Cdd:PRK09943 155 SYAINTGIPHSFSN 168
cupin_TcmJ-like cd06991
TcmJ monooxygenase and related proteins, cupin domain; This family includes TcmJ, a subunit of ...
 105-193 2.56e-07

TcmJ monooxygenase and related proteins, cupin domain; This family includes TcmJ, a subunit of the tetracenomycin (TCM) polyketide synthase (PKS) type II complex in Streptomyces glaucescens. TcmJ is a quinone-forming monooxygenase involved in the modification of aromatic polyketides synthesized by polyketide synthases of types II and III. Orthologs of TcmJ include the Streptomyces BenD (benastatin biosynthetic pathway), the Streptomyces olivaceus ElmJ (polyketide antibiotic elloramycin biosynthetic pathway), the Actinomadura hibisca PdmL (pradimicin biosynthetic pathway), the Streptomyces cyaneus CurC (curamycin biosynthetic pathway), the Streptomyces rishiriensis Lct30 (lactonamycin biosynthetic pathway), and the Streptomyces WhiE II (spore pigment polyketide biosynthetic pathway). Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380396 [Multi-domain]  Cd Length: 105  Bit Score: 47.29  E-value: 2.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559 105 RGGSARLL--AGTRGPNMIELWRWEMAPGEAYASGGHPAGTfELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRYA 182
Cdd:cd06991    1 RGGDLRILlsPKTVGATSGFMGTLTLAPGERVSEHYHPYSE-EFLYVVRGRLVVRVDGEPVVLEAGEALLVPRGVRHRLE 79

                         90
                 ....*....|...
gi 742394559 183 NEGEDT--LIFTM 193
Cdd:cd06991   80 NAGDEParLVFHL 92
ManC COG0662
Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];
107-191 3.08e-06

Mannose-6-phosphate isomerase, cupin superfamily [Carbohydrate transport and metabolism];


Pssm-ID: 440426 [Multi-domain]  Cd Length: 114  Bit Score: 44.36  E-value: 3.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 742394559 107 GSARLLAgtRGPNMIELWRWEMAPGEAYASGGHPAGTfELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRYANEGE 186
Cdd:COG0662   15 GSYEVLG--EGGERLSVKRITVPPGAELSLHVHPHRD-EFFYVLEGTGEVTIGDEEVELKAGDSVYIPAGVPHRLRNPGD 91


                 ....*
gi 742394559 187 DTLIF 191
Cdd:COG0662   92 EPLEL 96
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 25-81 3.36e-06

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 43.25  E-value: 3.36e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 742394559  25 RIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKG------SANPSIAILCKLAAALGLSVADIV 81
Cdd:COG1426    9 LLRQAREAKGLSLEDVAERTKISVSYLEAIEEGdfdalpGPVYVRGFLRSYARALGLDPEELL 71
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 21-81 5.11e-06

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 45.72  E-value: 5.11e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 742394559  21 AVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSVADIV 81
Cdd:PRK08154  28 ALGERVRTLRARRGMSRKVLAQASGVSERYLAQLESGQGNVSILLLRRVARALGCSLADLL 88
couple_hipB TIGR03070
transcriptional regulator, y4mF family; Members of this family belong to a clade of ...
 26-75 1.13e-05

transcriptional regulator, y4mF family; Members of this family belong to a clade of helix-turn-helix DNA-binding proteins, among the larger family pfam01381 (HTH_3; Helix-turn-helix). Members are similar in sequence to the HipB protein of E. coli. Genes for members of the seed alignment for this protein family were found to be closely linked to genes encoding proteins related to HipA. The HibBA operon appears to have some features in common with toxin-antitoxin post-segregational killing systems. [Regulatory functions, DNA interactions]


Pssm-ID: 213767 [Multi-domain]  Cd Length: 58  Bit Score: 41.49  E-value: 1.13e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 742394559   26 IKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGL 75
Cdd:TIGR03070   7 VRARRKALGLTQADLADLAGVGLRFIRDLENGKPTVRLDKVLRVLDALGL 56
HTH_26 pfam13443
Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to ...
 25-81 2.74e-05

Cro/C1-type HTH DNA-binding domain; This is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433211 [Multi-domain]  Cd Length: 63  Bit Score: 40.60  E-value: 2.74e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 742394559   25 RIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKG-SANPSIAILCKLAAALGLSVADIV 81
Cdd:pfam13443   1 KLRKLMADRGISKSDLARATGISRATLSRLRKGkPKRVSLDTLDKICDALGCQPGDLL 58
PRK13890 PRK13890
conjugal transfer protein TrbA; Provisional
 39-97 2.00e-04

conjugal transfer protein TrbA; Provisional


Pssm-ID: 237547 [Multi-domain]  Cd Length: 120  Bit Score: 39.35  E-value: 2.00e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 742394559  39 ELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALglsvadivnvtRAPAAYLIESQDI 97
Cdd:PRK13890  23 ELSERSGVSISFLSDLTTGKANPSLKVMEAIADAL-----------ETPLPLLLESTDL 70
PHA01976 PHA01976
helix-turn-helix protein
 25-77 5.26e-04

helix-turn-helix protein


Pssm-ID: 177330 [Multi-domain]  Cd Length: 67  Bit Score: 37.24  E-value: 5.26e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 742394559  25 RIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSANPSIAILCKLAAALGLSV 77
Cdd:PHA01976   6 QLIKARNARAWSAPELSRRAGVRHSLIYDFEADKRLPNLKTLLRLADALGVTL 58
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 21-80 5.34e-04

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 37.12  E-value: 5.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 742394559   21 AVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSAN-PSIAILCKLAAALGLSVADI 80
Cdd:pfam13560   1 ELGARLRRLRERAGLSQEALARRLGVSRSTLSRLETGRRGrPSPAVVERLARALGVDGAER 61
YozG COG3655
DNA-binding transcriptional regulator, XRE family [Transcription];
21-81 7.75e-04

DNA-binding transcriptional regulator, XRE family [Transcription];


Pssm-ID: 442872 [Multi-domain]  Cd Length: 69  Bit Score: 36.66  E-value: 7.75e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 742394559  21 AVSRRIKQQRKNQKLSLDELSRRAGVSKGMLVEIEKGSA-NPSIAILCKLAAALGLSVADIV 81
Cdd:COG3655    1 MIYVKLDELLAERGMTKKELAEATGISRATLSRLKNGKAkAVRLDTLEKICKALDCQPGDLL 62
AraC_binding pfam02311
AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization ...
 128-193 4.52e-03

AraC-like ligand binding domain; This family represents the arabinose-binding and dimerization domain of the bacterial gene regulatory protein AraC. The domain is found in conjunction with the helix-turn-helix (HTH) DNA-binding motif pfam00165. This domain is distantly related to the Cupin domain pfam00190.


Pssm-ID: 396749 [Multi-domain]  Cd Length: 134  Bit Score: 35.87  E-value: 4.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 742394559  128 MAPGEAYASGGHPagTFELLHVEQGVLSLTVEQTELRITPGCSAVARTDGPHRYANEGEDTLIFTM 193
Cdd:pfam02311  10 RYPGHSFPPHVHD--FYVIGYIERGVGRFRLNGRTYHLGPGDLFLLPPGEPHDYEPESEDGWRYRW 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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