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Conserved domains on  [gi|740979714|ref|WP_038763596|]
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DUF3138 family protein [Burkholderia pseudomallei]

Protein Classification

porin family protein; TonB-dependent siderophore receptor( domain architecture ID 10568325)

porin family protein is a member of a large superfamily consisting of classical (gram-negative ) porins which are non-specific channels for small hydrophillic molecules, maltoporin-like channels which have specificities for various sugars, and ligand-gated protein channels which cooperate with a TonB associated inner membrane complex to actively transport ligands via the proton motive force| TonB-dependent siderophore receptor acts as a channel to allow import of extracellular nutrients such as iron-siderophore complexes; similar to Pseudomonas aeruginosa type II pyoverdine receptor FpvAII

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF3138 pfam11336
Protein of unknown function (DUF3138); This family of proteins with unknown function appear to ...
1-524 0e+00

Protein of unknown function (DUF3138); This family of proteins with unknown function appear to be restricted to Proteobacteria.


:

Pssm-ID: 402783  Cd Length: 525  Bit Score: 913.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714    1 MKKKLICLLVAGALPGFAGAASTSAQIKALQAQLNALQAQVKELRTALASQHGAAGGGASSQGATAAAAAAPVDESSPDY 80
Cdd:pfam11336   1 MKKKLICAAIAGALPGFAGAAAKAAEIAALKAQLNALQAQMAELQKALAAAHAAAGGGASSQGAAAAAAAAPVDESSPDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714   81 GRASATLTNDDVTQMKQQIANQQLKVDALTDAANTGPIAGLSVTGYIDPTYVFNRAAGTSSFLFANHESNYNYFNSTFGD 160
Cdd:pfam11336  81 GRASATLTEDANAELKEQIANMELKVDALNDAANDGPIAGLSVTGYIDPTYIFNRAAGSSGFLFANHENNYAYFNSTFGD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  161 LYLDIKKTFGVGPMAPSAEITLMPNRGNGITLLQNSRGNIGNNILNTAVVNVPLSATTTLVAGLVPSFGGYEVQQSNQML 240
Cdd:pfam11336 161 LYLDIKKTFGVGPMAPSAEITIMPNRGNGITLLDNSRGGIGNNIINTAVINFPLSATTTFNAGLMNSFGGYEVQQSNQML 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  241 TLTHNLLYDFSDPGSYIGIGANYTKGNWAWKFLLGNEQYRTYGSVTQTGTNA-LGDPITTSNKVPTFTARVDYTWSSALD 319
Cdd:pfam11336 241 TLTHGLLYDFSDPGSYIGAGANWSHDNWAWKFLLANEQYRTHANLANTGNNAsLGEPITKSNKTPTFTARVDYTWSSALD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  320 LGGSFNIGRQTLGSATTQSGATVYGPGGQASSPYGAFFFAEADATYTLADIQYNAEIDYGQQQHAAFNGGRAQWYGLSLL 399
Cdd:pfam11336 321 LGGSFNAGRQTLGSANACAGATVFGPGCGAADPYGAFFFAEADASYTLADIQYNAEIDYGQQQHAAFNGGRAQWYGLSLL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  400 AHRKFNVPVLGRMGATLRYDFLANGKNGGGGGGIALNGNGMDTADGFGIDADCLATSKANGGLGFECKGANRQDVALDLL 479
Cdd:pfam11336 401 AHRKFMTDSLGKMGATLRYDFLANGKNGGGGGGIALGGGGFDGADGFGIDAACLASGAANGGLGFDCKGANRMALAAALL 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 740979714  480 FYPTQQITVKVEYRHDWANNKVFLRNDGSYSKSNDLLATQFIYSF 524
Cdd:pfam11336 481 FFPTDQFTLKFEYRHDWANNAVFLRNDGSMKKSNDLLAAQAIYSF 525
 
Name Accession Description Interval E-value
DUF3138 pfam11336
Protein of unknown function (DUF3138); This family of proteins with unknown function appear to ...
1-524 0e+00

Protein of unknown function (DUF3138); This family of proteins with unknown function appear to be restricted to Proteobacteria.


Pssm-ID: 402783  Cd Length: 525  Bit Score: 913.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714    1 MKKKLICLLVAGALPGFAGAASTSAQIKALQAQLNALQAQVKELRTALASQHGAAGGGASSQGATAAAAAAPVDESSPDY 80
Cdd:pfam11336   1 MKKKLICAAIAGALPGFAGAAAKAAEIAALKAQLNALQAQMAELQKALAAAHAAAGGGASSQGAAAAAAAAPVDESSPDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714   81 GRASATLTNDDVTQMKQQIANQQLKVDALTDAANTGPIAGLSVTGYIDPTYVFNRAAGTSSFLFANHESNYNYFNSTFGD 160
Cdd:pfam11336  81 GRASATLTEDANAELKEQIANMELKVDALNDAANDGPIAGLSVTGYIDPTYIFNRAAGSSGFLFANHENNYAYFNSTFGD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  161 LYLDIKKTFGVGPMAPSAEITLMPNRGNGITLLQNSRGNIGNNILNTAVVNVPLSATTTLVAGLVPSFGGYEVQQSNQML 240
Cdd:pfam11336 161 LYLDIKKTFGVGPMAPSAEITIMPNRGNGITLLDNSRGGIGNNIINTAVINFPLSATTTFNAGLMNSFGGYEVQQSNQML 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  241 TLTHNLLYDFSDPGSYIGIGANYTKGNWAWKFLLGNEQYRTYGSVTQTGTNA-LGDPITTSNKVPTFTARVDYTWSSALD 319
Cdd:pfam11336 241 TLTHGLLYDFSDPGSYIGAGANWSHDNWAWKFLLANEQYRTHANLANTGNNAsLGEPITKSNKTPTFTARVDYTWSSALD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  320 LGGSFNIGRQTLGSATTQSGATVYGPGGQASSPYGAFFFAEADATYTLADIQYNAEIDYGQQQHAAFNGGRAQWYGLSLL 399
Cdd:pfam11336 321 LGGSFNAGRQTLGSANACAGATVFGPGCGAADPYGAFFFAEADASYTLADIQYNAEIDYGQQQHAAFNGGRAQWYGLSLL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  400 AHRKFNVPVLGRMGATLRYDFLANGKNGGGGGGIALNGNGMDTADGFGIDADCLATSKANGGLGFECKGANRQDVALDLL 479
Cdd:pfam11336 401 AHRKFMTDSLGKMGATLRYDFLANGKNGGGGGGIALGGGGFDGADGFGIDAACLASGAANGGLGFDCKGANRMALAAALL 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 740979714  480 FYPTQQITVKVEYRHDWANNKVFLRNDGSYSKSNDLLATQFIYSF 524
Cdd:pfam11336 481 FFPTDQFTLKFEYRHDWANNAVFLRNDGSMKKSNDLLAAQAIYSF 525
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1-51 4.51e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.36  E-value: 4.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 740979714   1 MKKKLICLLVAgalpgFAGAASTSAQIKALQAQLNALQAQVKELRTALASQ 51
Cdd:COG4942    1 MRKLLLLALLL-----ALAAAAQADAAAEAEAELEQLQQEIAELEKELAAL 46
 
Name Accession Description Interval E-value
DUF3138 pfam11336
Protein of unknown function (DUF3138); This family of proteins with unknown function appear to ...
1-524 0e+00

Protein of unknown function (DUF3138); This family of proteins with unknown function appear to be restricted to Proteobacteria.


Pssm-ID: 402783  Cd Length: 525  Bit Score: 913.66  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714    1 MKKKLICLLVAGALPGFAGAASTSAQIKALQAQLNALQAQVKELRTALASQHGAAGGGASSQGATAAAAAAPVDESSPDY 80
Cdd:pfam11336   1 MKKKLICAAIAGALPGFAGAAAKAAEIAALKAQLNALQAQMAELQKALAAAHAAAGGGASSQGAAAAAAAAPVDESSPDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714   81 GRASATLTNDDVTQMKQQIANQQLKVDALTDAANTGPIAGLSVTGYIDPTYVFNRAAGTSSFLFANHESNYNYFNSTFGD 160
Cdd:pfam11336  81 GRASATLTEDANAELKEQIANMELKVDALNDAANDGPIAGLSVTGYIDPTYIFNRAAGSSGFLFANHENNYAYFNSTFGD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  161 LYLDIKKTFGVGPMAPSAEITLMPNRGNGITLLQNSRGNIGNNILNTAVVNVPLSATTTLVAGLVPSFGGYEVQQSNQML 240
Cdd:pfam11336 161 LYLDIKKTFGVGPMAPSAEITIMPNRGNGITLLDNSRGGIGNNIINTAVINFPLSATTTFNAGLMNSFGGYEVQQSNQML 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  241 TLTHNLLYDFSDPGSYIGIGANYTKGNWAWKFLLGNEQYRTYGSVTQTGTNA-LGDPITTSNKVPTFTARVDYTWSSALD 319
Cdd:pfam11336 241 TLTHGLLYDFSDPGSYIGAGANWSHDNWAWKFLLANEQYRTHANLANTGNNAsLGEPITKSNKTPTFTARVDYTWSSALD 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  320 LGGSFNIGRQTLGSATTQSGATVYGPGGQASSPYGAFFFAEADATYTLADIQYNAEIDYGQQQHAAFNGGRAQWYGLSLL 399
Cdd:pfam11336 321 LGGSFNAGRQTLGSANACAGATVFGPGCGAADPYGAFFFAEADASYTLADIQYNAEIDYGQQQHAAFNGGRAQWYGLSLL 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  400 AHRKFNVPVLGRMGATLRYDFLANGKNGGGGGGIALNGNGMDTADGFGIDADCLATSKANGGLGFECKGANRQDVALDLL 479
Cdd:pfam11336 401 AHRKFMTDSLGKMGATLRYDFLANGKNGGGGGGIALGGGGFDGADGFGIDAACLASGAANGGLGFDCKGANRMALAAALL 480
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 740979714  480 FYPTQQITVKVEYRHDWANNKVFLRNDGSYSKSNDLLATQFIYSF 524
Cdd:pfam11336 481 FFPTDQFTLKFEYRHDWANNAVFLRNDGSMKKSNDLLAAQAIYSF 525
BBP2 pfam07642
Putative beta-barrel porin-2, OmpL-like. bbp2; BBP2 is a family of putative porin proteins ...
120-524 5.79e-10

Putative beta-barrel porin-2, OmpL-like. bbp2; BBP2 is a family of putative porin proteins that are likely to be outer membrane beta barrel proteins porins.


Pssm-ID: 429570  Cd Length: 343  Bit Score: 60.81  E-value: 5.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  120 GLSVTGYIDPTYVFNraagtssflfANHESNYNYFNSTFGD---------LYLDIKKTFGVGPmapsAEITLM------P 184
Cdd:pfam07642   1 GLTISGYVDGYYSYN----------FNKPDNGTNPPVTFADrnnefnlnlAFLKISKATDKVG----ARFDLQfgtyanA 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  185 NRGNGITLLQNSRGNIGN-NILNTAVvNVPLSATTTLVAGLVPSFGGYEVQQSNQMLTLTHNLLYDFSdPGSYIGIGANY 263
Cdd:pfam07642  67 NQALGSPNTDTTPGYLKAiPQAYVGY-AIPVGKGLSVDAGHFPTHIGYESIFAPDNWNYSRSYLFNNG-PFFHTGVRASY 144
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  264 T-KGNWAwkfllgneqyrTYGSVTqTGTNALGDPittSNKVPTFTARVDYTWSSALDLGGSFNIGRQTLGSATTQSGatv 342
Cdd:pfam07642 145 TsSDKLS-----------LSLGVL-NGWDRIFFD---GNGNPAFGGQLTYSPDGKLTLNLNTYYGPDKPGPLNRQNR--- 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  343 ygpggqasspygafFFAEADATYTLAD-IQYNAEIDYGQQQHAAFNGGR--AQWYGLSLLAHRKFNvpvlGRMGATLRYD 419
Cdd:pfam07642 207 --------------FIYDLVLTYKLTDkLTLTLNLDYGFEQGDKVIGSGssAEWYGGALYLSYDFT----DKFALAGRGE 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740979714  420 FLAngknggggggialngngmdtaDGFGIDADCLATSKANGGLGFEckganrqdVALDLLFYPTQQITVKVEYRHDWANN 499
Cdd:pfam07642 269 YFR---------------------DKDGVGGGIISTGTGGGFKVWG--------LTLTPDYKPTGNLTLRPELRYDNSSD 319
                         410       420
                  ....*....|....*....|....*
gi 740979714  500 KVFLRNDGSySKSNDLLATQFIYSF 524
Cdd:pfam07642 320 DTFPKGNGK-PRSQTRFTLAAIFSF 343
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
13-51 2.13e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 39.98  E-value: 2.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 740979714   13 ALPGFAGAASTSAQIKALQAQLNALQAQVKELRTALASQ 51
Cdd:pfam12795 137 NGPAPPGEPLSEAQRWALQAELAALKAQIDMLEQELLSN 175
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1-51 4.51e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.36  E-value: 4.51e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 740979714   1 MKKKLICLLVAgalpgFAGAASTSAQIKALQAQLNALQAQVKELRTALASQ 51
Cdd:COG4942    1 MRKLLLLALLL-----ALAAAAQADAAAEAEAELEQLQQEIAELEKELAAL 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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