|
Name |
Accession |
Description |
Interval |
E-value |
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
1-384 |
7.07e-153 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 436.67 E-value: 7.07e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 1 MKNKIALTLISFLANFIMAGFASQFGMLIEPIAVRYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSI 80
Cdd:PRK03699 2 NSNRIKLTWISFLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 81 VFLCALAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAGVVFPLITTFALTHNMSW 160
Cdd:PRK03699 82 MILAVAGLMFSHSLALFSIAMFVLGVVSGITMSIGTFLITHVYEGKQRGSRLLFTDSFFSMAGMIFPIIAAYLLARSIEW 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 161 SYSYLSVGIVALLTLGVVMLTRFNACETAPEADRTDAVKSEWNPGIISGGIGLFLGMLALYTFLTWAPLFVKNKFGIPFE 240
Cdd:PRK03699 162 YWVYACIGLVYVAIFILTLFSEFPALGKHAPKADKPVAKEKWGIGVLFLAIAALLYILAQLTFISWVPEYAQKKFGMSLE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 241 EAGNIITQYWGAALVGALVSTVIVARVKIHYFLLSIILLACVITTIIVTKEQISGLDYLAYSYGFVCAALYNSFIAYGVS 320
Cdd:PRK03699 242 DAGNLVSNFWMAYMVGMWIFSFIVRFFDLQRILTVLAGLALVLMYLFVNTDDPSHLLYAILGLGFFSSAIYTTIITLGSQ 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740854247 321 FVKRASSQNVSYILISGSAGAMFSPAISALMEKTMGLQKIMYAIPVLYLIIFVMLMGTLKLKRK 384
Cdd:PRK03699 322 QTKVASPKLVNFILTCGTIGTMLTFVVTSPIVAHFGLQAALLTANGLYAVVFVMCILLGFVSKH 385
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
8-374 |
4.34e-64 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 209.10 E-value: 4.34e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 8 TLISFLANFIMAGFASQFGMLIEPIavrYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMtLIIYSIVFLCALA 87
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEA---FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRT-LILGLLLISLALA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 88 MHVSPGLWPV-MVAMALVGFCGGIGLCVAGTIVVSVWQDRiQSTMLVVQDATFNVAGVVFPLITTFALTHNMSWSYSYLS 166
Cdd:cd17333 77 LIFATPSIYLfVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLI 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 167 VGIVALLTLGVVMLTRFNACETA------PEADRTDAVKSEWNPGIISGGIGLFLGMLALYTFLTWAPLFVKNKFGIPFE 240
Cdd:cd17333 156 IGLIYLLLAILILLTLFPELPSArnpqqsVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 241 EAGNIITQYWGAALVGALVSTVIVARVKIHYFLLSIILLACVITTIIVTKEQISGLDYLAYSYGFVCAALYNSFIAYGVS 320
Cdd:cd17333 236 LAGYLLSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGIS 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 740854247 321 FVKRASSQNVSYILISGSAGAMFSPAISALMEKTMGLQKIMYAIPVLYLIIFVM 374
Cdd:cd17333 316 NLPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-384 |
6.99e-38 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 140.37 E-value: 6.99e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 1 MKNKIALTLISFLANFIMAGFASQFGMLIEPIAVRYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSI 80
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 81 VFLCALAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRiQSTMLVVQDATFNVAGVVFPLITTFALTHNMS- 159
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLGLSl 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 160 -WSYSYLSVGIVALLTLGVVMLTRFNACETAPEADRTDAVKSEW---NPGIISGGIGLFLGMLALYTFLTWAPLFVKNKF 235
Cdd:COG0738 162 sWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSllkNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 236 GIPFEEAGNIITQYWGAALVGALVSTVIVARVKIHYFLLSIILLACVITTIIVTKEQISGLDYLAYSYGFVCAALYNSFI 315
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740854247 316 AYGVSFVKRASSQNVSYILISGSAGAMFSPAISALMEKTMGLQKIMYAIPVLYLIIFVMLMGTLKLKRK 384
Cdd:COG0738 322 SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRK 390
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
2-317 |
1.01e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 74.63 E-value: 1.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 2 KNKIALTLISFLANFIMAGFASQFGMLIEPIAVRYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIV 81
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 82 FLCALAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAGVVFPLITTFaLTHNMSWS 161
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL-LADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 162 YSYLSVGIVALLTLGVVMLTRFNACETAPEADRTDAVKSEWNPGIISGGIGLFLGMLALYTFLTWAPLFVKNKFGIPFEE 241
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASA 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 740854247 242 AGNIITQYWGAALVGALVSTVIVARVKIHYFLLSIILLACVITTIIVTKEQISGLDYLAYSYGFVCAALYNSFIAY 317
Cdd:COG2814 245 AGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
9-384 |
1.39e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 74.53 E-value: 1.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 9 LISFLANFIMAGFASQFGMLIEPIAVRYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCALAM 88
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 89 HVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAGVVFPLITTfALTHNMSWSYSYLSVG 168
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAP-LLIAAFGWRNAFLILG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 169 IVALLTLGVVML------TRFNACETAPEADRTDAVKsewNPGIISGGIGLFLGMLALYTFLTWAPLFVKNKFGIPFEEA 242
Cdd:COG2223 167 ILLLVVAVLAWLflrdppAGAAAAAKASLRDQLEALR---DPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 243 GNIITQYWGAALVGALVSTVIVARVKIHYFLLSIILLACVITTIIVTKEQISGLDYLAYSYGFVCAALYNS--FIAYGVS 320
Cdd:COG2223 244 GLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGavFALVPDI 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740854247 321 FVKRASSQNVSYILISGSAGAMFSP-AISALMEKTMGLQKIMYAIPVLYLIIFVMLMGTLKLKRK 384
Cdd:COG2223 324 FPTKNAGAVYGLVGAAGGLGGFLGPlLFGALLDATGSYTAAFLVFAVLALVALVLTLLLYRRPRR 388
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-384 |
1.28e-13 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 71.44 E-value: 1.28e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 9 LISFLANFIMAGFASQFGMLIEPIAVRYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCALAM 88
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 89 HVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAGVVFPLITTFALTHnMSWSYSYLSVG 168
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA-FGWRAAFLILG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 169 IVALLTLGVVMLTrfnacetapeadrtdavksewnpgiisGGIGLFLGMLALYTFLTWAPLFVKNKFGIPFEEAGNIITQ 248
Cdd:COG2271 172 LPGLLLALLRFWL---------------------------LALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSL 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 249 YWGAALVGALVSTVIVARV-KIHYFLLSIILLACVITTIIVTKEQISGLDYLAYS-YGFVCAALYNSFIAYGVSFV-KRA 325
Cdd:COG2271 225 PFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFlAGFGLGGAFGLLWALAAELFpKKA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 740854247 326 SSQNVSYILISGSAGAMFSPAISALMEKTMGLQKIMYAIPVLYLIIFVMLMGTLKLKRK 384
Cdd:COG2271 305 RGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
10-345 |
5.31e-11 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 63.21 E-value: 5.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 10 ISFLANFIMAGFASQFGMLIEPIAVRYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCALAMH 89
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 90 VSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAGVVFPLITTFaLTHNMSWSYSYLSVGI 169
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL-LASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 170 VALLTLGVVMLTR------FNACETAPEADRTDAVKSEWNPGIISGGIGLFLGMLALYTFLTWAPLFVKnKFGIPFEEAG 243
Cdd:pfam07690 160 LSLLAAVLLLLPRpppeskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 244 NIITQYWGAALVGALVSTVIVARVKIH---YFLLSIILLACVITTIIVTKEQISGLDYLAYSYGFVCAALYNSFIAYGVS 320
Cdd:pfam07690 239 LLLGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....*.
gi 740854247 321 FV-KRASSQNVSYILISGSAGAMFSP 345
Cdd:pfam07690 319 LApKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
12-375 |
3.06e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 61.29 E-value: 3.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 12 FLANFIMAGFASQFGMLIEPIAVRYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCALAMHVS 91
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 92 PGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAGVVFPLITTFALTHNM-SWSYSYLSVGIV 170
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLIAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 171 ALLTLGVVMLTRFNACETAPEADRTDAVKSEW--------NPGIISGGIGLFLGMLALYTFLTWAPLFVKNKFGIPFEEA 242
Cdd:cd06174 162 ALLAAILLLLVVPDPPESARAKNEEASSKSVLkllkrvlkNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 243 GNIITQYWGAALVGALVSTVIVARVKIHYFLLSIILLACVITTIIVTKEQISGLDYLAYSYGFVCAALYNSFIAYGVSFV 322
Cdd:cd06174 242 GLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 740854247 323 KRASSQNVSY--ILISGSAGAMFSPAISALMEKTMGLQKIMYAIPVLYLIIFVML 375
Cdd:cd06174 322 FPPEIRGTAFglLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
55-283 |
5.03e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 54.49 E-value: 5.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 55 LAGTIAAFF---LIEKIGVKRMTLIIYSIVFLCALAMHVSPGLWPVMVAMALVGFcgGIGLC-VAGTIVVSVWQDRIQST 130
Cdd:COG2807 64 LAFGLFAPLaprLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA--GIAVGnVLLPGLIKRWFPDRVGL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 131 MLVVQDATFNVAGVVFPLItTFALTHNMSWSYSYLSVGIVALLTLGVVMLTRFNACETAPEADRTDAVKSEW-NPGIISG 209
Cdd:COG2807 142 MTGLYTAAMGLGAALAAGL-TVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWrSPLAWLL 220
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740854247 210 GIGLFLGMLALYTFLTWAPLFVKNKfGIPFEEAGNIITQYWGAALVGALVSTVIVARVKIHYFLLSIILLACVI 283
Cdd:COG2807 221 TLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLA 293
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
63-356 |
4.19e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 51.51 E-value: 4.19e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 63 FLIEKIGVKRMTLIIYSIVFLCALAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVA 142
Cdd:cd17312 60 FLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFG 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 143 GVVFPLITTFALTHNmSWSYSYLSVGIVALLTlGVVMLTRFnacetapeadrtdavkSEWNPGIISGGIGLFLGMLALYT 222
Cdd:cd17312 140 GILAPILAASLASYY-GWRAAFLVPGIVGLVV-AIILFFFL----------------RDSPPYVWVLSLAYAFVYIVRYA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 223 FLTWAPLFVKNKFGIPFEEAGNIITQYWGAALVGALVSTVIVARV-------KIHYFLLSIILLACVITTIIVTKEQISG 295
Cdd:cd17312 202 CLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfggrrapIAVIYMLLMTLSLALFWFFPHNKLLSIV 281
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 740854247 296 LDYLAysyGFVCAALYNSF--IAYGVSFVKRASSQNVSYILISGSAGAMFSPAISALMEKTMG 356
Cdd:cd17312 282 LLFLI---GFFVGGPINLIggAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG 341
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
4-267 |
7.84e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 50.73 E-value: 7.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 4 KIALTLISFLANFIMAGFASQFGMLIEPIAVRYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIVFL 83
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 84 CALAMHVSPGLWPVMVAMALVGFCG-GIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAGVVFPLITTfALTHNMSWSY 162
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGA-ALIEAFGWRT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 163 SYLSVGIVALLTLGVVMLTRFNacETAPEADRTDAVKSEWNPGIISGG-----------IGLFLGMLALYTFLTWAPLFV 231
Cdd:cd17355 160 ALLVLALLALLVLVPVLLLLRR--RPADLALRAYDDASPASPGSTLKEalrsasfwllaLAFFLCGFAVVGLIVHLVPYL 237
|
250 260 270
....*....|....*....|....*....|....*.
gi 740854247 232 KNkFGIPFEEAGNIITQYWGAALVGALVSTVIVARV 267
Cdd:cd17355 238 AD-RGISPAAAAVALALIGLFNIVGRLLSGWLGDRY 272
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
82-316 |
5.02e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.14 E-value: 5.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 82 FLCALAM---HVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAGVVFPLITTFALTHNM 158
Cdd:TIGR00881 68 ILCAIVNlffGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 159 SWSYSYLSVGIVALLT--LGVVMLTRFNACETAPEAD--RTDAVKSEW-------------------NPGIISGGIGLFL 215
Cdd:TIGR00881 148 SWHWVFIVPGIIAIIVslICFLLLRDSPQSCGLPPAEemPNEEPDGDAekkeeeltkkqiflqyvllNKVLWYISLGYVF 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 216 GMLALYTFLTWAPLFVKNKFGIPFEEAGNIITQYWGAALVGALVSTVIVAR-VKIHYFLLSIILLACVITTIIVTKEQIS 294
Cdd:TIGR00881 228 VYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKlFNGRRGPLAVFFMALIIVSLLVYWLNPA 307
|
250 260
....*....|....*....|..
gi 740854247 295 GLDYLAYSYGFVCAALYNSFIA 316
Cdd:TIGR00881 308 ANPLMDLICLFALGFLVYGPQM 329
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
8-376 |
9.88e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 9.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 8 TLISFLANFIMAGFASQFGMLIEPIAVRYSADVNT--VASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCA 85
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLlqTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 86 LAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVaGVVFPLITTFALTHNMSWSYSYL 165
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAL-GALLAALVASLLIPLLSGDWGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 166 SVGIVALLTLGVVMLTRfnacetapeadrtdavksewnPGIISGGIGLFLGMLALYTFLTWAPLFVKNKFGIPFEEAGNI 245
Cdd:cd17316 160 ILFLIGALPALLALLLR---------------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 246 ITQYWGAALVGALVSTVIVARVKIHYFLLsIILLACVITTIIVTKEQISGLDYLAYS---YGFVCAALYNSFIAYGVSFV 322
Cdd:cd17316 219 LLLISLGALVGALIAGLLSDRIGRKKTLV-IGLILSGILALPLFYLLSGSPTLLLLLlfiLSFFVGGVWGALYAYLAELF 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 740854247 323 K---RASSQNVSYILiSGSAGAMFSPAISALMEKTMGLQKIMYAIPVLYLIIFVMLM 376
Cdd:cd17316 298 PtevRATGVGLSYNL-GRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-143 |
1.95e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 6 ALTLISFLANFIMAGFASQFGMLIEPIAVRYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCA 85
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGL 287
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 740854247 86 LAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAG 143
Cdd:COG2814 288 LLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
42-247 |
2.79e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 42.60 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 42 TVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCALAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVS 121
Cdd:cd17329 36 IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 122 VWQDRIQSTMLVVQDATFNVAGVVFPLITTFALTHNMSWSysyLSVGIVALLTLGVVMLTRFNACETAPEADRTDAVKSE 201
Cdd:cd17329 116 VTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLL---FLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRG 192
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 740854247 202 WNPGIISGGIGLFLGMLALYTFL-----TWAPLFVKNKFGIPFEEAGNIIT 247
Cdd:cd17329 193 YKIVLRDRAFLLFLLASFLISLIyfqleSTLPVYVVEILGLGESLLGLLLA 243
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
43-267 |
3.43e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 42.17 E-value: 3.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 43 VASIFSLlngGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCALAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSV 122
Cdd:cd17319 43 IASAFFL---GYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEW 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 123 WQDRIQSTMLVVQDATFNVAGVVFPLITTFALTHnMSWSYSYLSVGIVALLTLGVVMLtrfnacetapeadrtdavkseW 202
Cdd:cd17319 120 FPARERGRATGLFNSGAPLGAAIGPPLSGWLLLL-FGWRWAFIIEGLLGLLLAVLWWF---------------------Y 177
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740854247 203 NPGIISGGIGLFLGMLALYTFLTWAPLFVKNKFGIPFEEAGNIITQYWGAALVGALVSTVIVARV 267
Cdd:cd17319 178 LRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL 242
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
63-287 |
4.41e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 41.79 E-value: 4.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 63 FLIEKIGVKRMTLIIYSIVFLCALAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVA 142
Cdd:cd17474 56 VLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 143 GVVFPLITtfALTHNMSWSYSYLSVGIVALLTLGVVMLT---RFNACETAPEADRTDAVKSEWNPGIISGGIGLFLGMLA 219
Cdd:cd17474 136 IAVGPLLG--GLLAAISWRYPFFLLAALIPVAFLAILFLlpePKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFL 213
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740854247 220 LYTFLTWAPLFVKNKFGIPFEEAGNIITqywGAALVGALVSTVIVARVKIHYFLLSIILLACVITTII 287
Cdd:cd17474 214 YFAFLTYLPFLLELLYGISPIIIGLLFA---GWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALS 278
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
38-182 |
6.68e-04 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 41.42 E-value: 6.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 38 ADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCALAMHVSPGLWPVMVAMALVGFCGGIGlCVAGT 117
Cdd:cd17365 203 YSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLAGACVNG-AQVGL 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740854247 118 IVVS--VWQDRIQSTMLVVQDATFNVAGVVFPLITTFALTHNMSWSYSYLSVGIVALLTLGVVMLTR 182
Cdd:cd17365 282 YALAarFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLALAIPAALGALAVLLLR 348
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-376 |
1.10e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.66 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 15 NFIMAGFASQFGMLIEPIAVRYS------ADVNTVASIFSLlngGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCALAM 88
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHdlggseAVAGLVVGLFTL---AALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 89 HVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAGVVFPLITTFALTHNMSWSYSYLSVG 168
Cdd:cd17489 79 LLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 169 IVALLTLGVVMLTRFNACETAPEADRTDAVKSEWNPGIISGGIGLFLGMLALYTFLTWAPLFVKNkfgIPFEEAGNIITQ 248
Cdd:cd17489 159 LALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAE---RGISNAGLFFTV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 249 YWGAALVGALVSTVIVARVKIHYFLLSIILLACVITTIIVTKEQISGLDYLAYSYGFVCAALYNSFIAYGVSFV---KRA 325
Cdd:cd17489 236 YAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVpphRRG 315
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 740854247 326 SSQNVSYILISGSAGamFSPAISALMEKTMGLQKIMYAIPVLYLIIFVMLM 376
Cdd:cd17489 316 AANGTFFIFFDLGIG--LGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
46-376 |
1.67e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 46 IFSLLNGgalagtiaafFLIEKIGVKRM---TLIIYSIVFLCALamhVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSV 122
Cdd:cd17473 50 LFAPLAG----------WLADRFGRKRLliaGLLLYGIGGVAGL---FLDSLYALLASRALLGIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 123 WQDRIQSTMLVVQDATFNVAGVVFPLITTFALThnMSWSYSYLsVGIVALLTLGVVMLTRFnacETAPEADRTDAVKSEW 202
Cdd:cd17473 117 FEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE--IGWRAPFL-VYLLALPVLILVLLFLP---EPARKSKSAASPGAAT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 203 NPGIISG-----GIGLFLGMLALYTFLTWAPLFVKNKFGIPFEEAGNIITQYWGAALVGALVSTVIVARVKIHYFLLSII 277
Cdd:cd17473 191 AAALPWKrvlpiYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGF 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 278 LLACVITTIIVTKEQISGLDYLAYSYGFVCAALY---NSFIAYGVSFVKRAssQNVSYILISGSAGAMFSPAISALMEK- 353
Cdd:cd17473 271 ALMALGFLLLALASGLWVVLLGAILAGLGFGLLLptlNSWAMSLVPPELRG--RAMGIVTSAFFLGQFLSPLVLGPLVNl 348
|
330 340
....*....|....*....|...
gi 740854247 354 TMGLQKIMYAIPVLYLIIFVMLM 376
Cdd:cd17473 349 TGGLSGAFLILGVLALVLAIVLL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-182 |
4.88e-03 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 38.71 E-value: 4.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 2 KNKIALTLISFLANFIMAGFASQFGMLIEPiavRYSADVNTVASIFSLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIV 81
Cdd:cd17325 199 RRLLALFLAIFVLAFAFGALEPFLPLYAAE---LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 82 FLCALAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRIQSTMLVVQDATFNVAGVVFPLITTFaLTHNMSWS 161
Cdd:cd17325 276 AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF-LYDAFGFA 354
|
170 180
....*....|....*....|.
gi 740854247 162 YSYLSVGIVALLTLGVVMLTR 182
Cdd:cd17325 355 TPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
48-288 |
8.41e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 37.99 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 48 SLLNGGALAGTIAAFFLIEKIGVKRMTLIIYSIVFLCALAMHVSPGLWPVMVAMALVGFCGGIGLCVAGTIVVSVWQDRI 127
Cdd:cd17475 38 SALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 128 QSTMLVVQDATFNVAGVVFPLITTFaLTHNMSWSYSYLSVGIVALLTLGVVMLTRFNACETAPEADRTDAVKSE-----W 202
Cdd:cd17475 118 RGLAMGIRQTGVPLGGALAAALLPP-LALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLLRSlkevlR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854247 203 NPGIISGGIGLFLGMLALYTFLTWAPLFVKNKFGIPFEEAGNIITqywgAALVGALVSTVIVARVKIHYF------LLSI 276
Cdd:cd17475 197 NRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLA----VAQLGGALGRIGLGRVSDRVFggrrrpVLVI 272
|
250
....*....|..
gi 740854247 277 ILLACVITTIIV 288
Cdd:cd17475 273 TAAIAAAALLVL 284
|
|
| |
