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Conserved domains on  [gi|740854203|ref|WP_038639456|]
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MULTISPECIES: AraC family transcriptional regulator [Citrobacter]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 13307529)

AraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
181-262 4.55e-22

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.84  E-value: 4.55e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203   181 WTAQEIAGHLSIGTSTLRRRLQMES-QSYRQIVEEVRMSCALSQLQSTTLPIGEIALRCGYLSGSRFTARFRQHYGCLPK 259
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETgTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 740854203   260 QVR 262
Cdd:smart00342  82 EYR 84
PRK15186 super family cl33102
AraC family transcriptional regulator; Provisional
 24-260 2.60e-15

AraC family transcriptional regulator; Provisional


The actual alignment was detected with superfamily member PRK15186:

Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 73.95  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203  24 LHQVKLFSAAICHITQGSKVIIQDDNRLVAGPGELIIIPA-NTPLEIINQPEQGAFRSDLLLLSASIISTFKNNWV---K 99
Cdd:PRK15186  31 LQGLNLLQSVLIKLTTGKISITTSSGEYITASGPMLIFLAkDQTIHITMEETHEQLNYNLIELDSASIKNAYNFFLyehA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 100 DF--PPAKLTS--LCTPMSNGLAFMWESLLDAVR-QDLPAKLQEHQAMGLLLALLHDGVAGPLLIERRFN-LTEQVRQLI 173
Cdd:PRK15186 111 DFsaPLTKPTTkhLLAPIETGVARVFNLLHSSNKsQKLSQDKKEYLIRFLLSEFIYEPEAFALFRELSQNtLAENIYNII 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 174 MLSPAKLWTAQEIAGHLSIGTSTLRRRLQMESQSYRQIVEEVRMSCALSQLQSTTLPIGEIALRCGYLSGSRFTARFRQH 253
Cdd:PRK15186 191 ISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKH 270


                 ....*..
gi 740854203 254 YGCLPKQ 260
Cdd:PRK15186 271 FKTTPSE 277
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
181-262 4.55e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.84  E-value: 4.55e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203   181 WTAQEIAGHLSIGTSTLRRRLQMES-QSYRQIVEEVRMSCALSQLQSTTLPIGEIALRCGYLSGSRFTARFRQHYGCLPK 259
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETgTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 740854203   260 QVR 262
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
157-262 9.11e-16

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 74.82  E-value: 9.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 157 LLIERRFNLTEQVRQLIMLSPAKLWTAQEIAGHLSIGTSTLRRRLQMES-QSYRQIVEEVRMSCALSQLQSTTLPIGEIA 235
Cdd:COG2207  145 LLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETgTSPKQYLRELRLERAKRLLAETDLSISEIA 224

                         90       100
                 ....*....|....*....|....*..
gi 740854203 236 LRCGYLSGSRFTARFRQHYGCLPKQVR 262
Cdd:COG2207  225 YELGFSSQSHFSRAFKKRFGVTPSEYR 251
HTH_18 pfam12833
Helix-turn-helix domain;
186-262 9.19e-16

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 70.31  E-value: 9.19e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740854203  186 IAGHLSIGTSTLRRRLQMES-QSYRQIVEEVRMSCALSQL-QSTTLPIGEIALRCGYLSGSRFTARFRQHYGCLPKQVR 262
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELgLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 24-260 2.60e-15

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 73.95  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203  24 LHQVKLFSAAICHITQGSKVIIQDDNRLVAGPGELIIIPA-NTPLEIINQPEQGAFRSDLLLLSASIISTFKNNWV---K 99
Cdd:PRK15186  31 LQGLNLLQSVLIKLTTGKISITTSSGEYITASGPMLIFLAkDQTIHITMEETHEQLNYNLIELDSASIKNAYNFFLyehA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 100 DF--PPAKLTS--LCTPMSNGLAFMWESLLDAVR-QDLPAKLQEHQAMGLLLALLHDGVAGPLLIERRFN-LTEQVRQLI 173
Cdd:PRK15186 111 DFsaPLTKPTTkhLLAPIETGVARVFNLLHSSNKsQKLSQDKKEYLIRFLLSEFIYEPEAFALFRELSQNtLAENIYNII 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 174 MLSPAKLWTAQEIAGHLSIGTSTLRRRLQMESQSYRQIVEEVRMSCALSQLQSTTLPIGEIALRCGYLSGSRFTARFRQH 253
Cdd:PRK15186 191 ISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKH 270


                 ....*..
gi 740854203 254 YGCLPKQ 260
Cdd:PRK15186 271 FKTTPSE 277
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 144-258 1.52e-13

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 68.87  E-value: 1.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 144 LLLALLHD-GVAGPLLIERRFNLTEQVRQLIMLSPAKLWTAQEIAGHLSIGTSTLRRRLQMESQSYRQIVEEVRMSCALS 222
Cdd:PRK15185 185 LLTAFLRLpESYEIILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAK 264

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 740854203 223 QLQSTTLPIGEIALRCGYLSGSRFTARFRQHYGCLP 258
Cdd:PRK15185 265 LLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTP 300
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 20-71 7.62e-03

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 34.54  E-value: 7.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 740854203   20 HLHRlhqvklFSAAICHITQGSKVIIQDDNRLVAGPGELIIIPANTPLEIIN 71
Cdd:pfam07883  14 HRHP------GEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRFRN 59
cupin_YP766765-like cd20299
Rhizobium leguminosarum YP_766765.1 and related proteins, cupin domain; This family includes ...
 36-77 9.16e-03

Rhizobium leguminosarum YP_766765.1 and related proteins, cupin domain; This family includes mostly bacterial proteins homologous to Rhizobium leguminosarum YP_766765.1, a protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380433 [Multi-domain]  Cd Length: 90  Bit Score: 34.57  E-value: 9.16e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 740854203  36 HITQGSKVIIQDDNRLVAGPGELIIIPANTPLEIINQPEQGA 77
Cdd:cd20299   42 VVLEGELTVTTDGEEVVLGPGDSCYIPPGETRSIDNRTNGPA 83
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
181-262 4.55e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 86.84  E-value: 4.55e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203   181 WTAQEIAGHLSIGTSTLRRRLQMES-QSYRQIVEEVRMSCALSQLQSTTLPIGEIALRCGYLSGSRFTARFRQHYGCLPK 259
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETgTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81


                   ...
gi 740854203   260 QVR 262
Cdd:smart00342  82 EYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
157-262 9.11e-16

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 74.82  E-value: 9.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 157 LLIERRFNLTEQVRQLIMLSPAKLWTAQEIAGHLSIGTSTLRRRLQMES-QSYRQIVEEVRMSCALSQLQSTTLPIGEIA 235
Cdd:COG2207  145 LLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETgTSPKQYLRELRLERAKRLLAETDLSISEIA 224

                         90       100
                 ....*....|....*....|....*..
gi 740854203 236 LRCGYLSGSRFTARFRQHYGCLPKQVR 262
Cdd:COG2207  225 YELGFSSQSHFSRAFKKRFGVTPSEYR 251
HTH_18 pfam12833
Helix-turn-helix domain;
186-262 9.19e-16

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 70.31  E-value: 9.19e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740854203  186 IAGHLSIGTSTLRRRLQMES-QSYRQIVEEVRMSCALSQL-QSTTLPIGEIALRCGYLSGSRFTARFRQHYGCLPKQVR 262
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELgLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 24-260 2.60e-15

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 73.95  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203  24 LHQVKLFSAAICHITQGSKVIIQDDNRLVAGPGELIIIPA-NTPLEIINQPEQGAFRSDLLLLSASIISTFKNNWV---K 99
Cdd:PRK15186  31 LQGLNLLQSVLIKLTTGKISITTSSGEYITASGPMLIFLAkDQTIHITMEETHEQLNYNLIELDSASIKNAYNFFLyehA 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 100 DF--PPAKLTS--LCTPMSNGLAFMWESLLDAVR-QDLPAKLQEHQAMGLLLALLHDGVAGPLLIERRFN-LTEQVRQLI 173
Cdd:PRK15186 111 DFsaPLTKPTTkhLLAPIETGVARVFNLLHSSNKsQKLSQDKKEYLIRFLLSEFIYEPEAFALFRELSQNtLAENIYNII 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 174 MLSPAKLWTAQEIAGHLSIGTSTLRRRLQMESQSYRQIVEEVRMSCALSQLQSTTLPIGEIALRCGYLSGSRFTARFRQH 253
Cdd:PRK15186 191 ISDISRKWALKDISDSLYMSCSTLKRKLKQENTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKH 270


                 ....*..
gi 740854203 254 YGCLPKQ 260
Cdd:PRK15186 271 FKTTPSE 277
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 144-258 1.52e-13

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 68.87  E-value: 1.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 144 LLLALLHD-GVAGPLLIERRFNLTEQVRQLIMLSPAKLWTAQEIAGHLSIGTSTLRRRLQMESQSYRQIVEEVRMSCALS 222
Cdd:PRK15185 185 LLTAFLRLpESYEIILSSAQITLKERVYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEEGTSFSDIYLSARMNQAAK 264

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 740854203 223 QLQSTTLPIGEIALRCGYLSGSRFTARFRQHYGCLP 258
Cdd:PRK15185 265 LLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTP 300
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 136-260 9.52e-13

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 66.49  E-value: 9.52e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 136 LQEHQAMGLLLALLHDgvagpllierrfNLTEQVRQLIMLSPAKLWTAQEIAGHLSIGTSTLRRRLQMESQSYRQIVEEV 215
Cdd:PRK09978 126 LEDEHFIPLLLNVLQP------------NMRTRVCTVINNNIAHEWTLARIASELLMSPSLLKKKLREEETSYSQLLTEC 193

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 740854203 216 RMSCALSQLQSTTLPIGEIALRCGYLSGSRFTARFRQHYGCLPKQ 260
Cdd:PRK09978 194 RMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTE 238
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 168-262 4.77e-11

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 61.71  E-value: 4.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 168 QVRQLIMLSPAKLWTAQEIAGHLSIGTSTLRRRLQME-SQSYRQIVEEVRMSCALSQLQSTTLPIGEIALRCGYLSGSRF 246
Cdd:COG4977  214 RAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAAtGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHF 293

                         90
                 ....*....|....*.
gi 740854203 247 TARFRQHYGCLPKQVR 262
Cdd:COG4977  294 RRAFRRRFGVSPSAYR 309
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
 158-258 7.44e-11

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 61.20  E-value: 7.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 158 LIERRFNLT--EQVRQLIMLSPAKLWTAQEIAGHLSIGTSTLRRRLQMESQSYRQIVEEVRMSCALSQLQSTTLPIGEIA 235
Cdd:PRK15044 184 FLERAIKITtkEKVYNIIISDLTRKWSQAEVAGKLFMSVSSLKRKLAAEEVSFSKIYLDARMNQAIKLLRMGAGNISQVA 263

                         90       100
                 ....*....|....*....|...
gi 740854203 236 LRCGYLSGSRFTARFRQHYGCLP 258
Cdd:PRK15044 264 TMCGYDTPSYFIAIFKRHFKITP 286
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 157-261 2.21e-10

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 59.33  E-value: 2.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 157 LLIERRFNLTEQVRQLIMLSPAKLWTAQEIAGHLSIGTSTLRRRLQMESQSYRQIVEEVRMSCAlSQLQSTTLPIGEIAL 236
Cdd:PRK09940 127 LLTNGVLSVSGKVRNIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTTFSQILLDARMQHA-KNLIRVEGSVNKIAE 205

                         90       100
                 ....*....|....*....|....*
gi 740854203 237 RCGYLSGSRFTARFRQHYGCLPKQV 261
Cdd:PRK09940 206 QCGYASTSYFIYAFRKHFGNSPKRV 230
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 160-262 1.27e-09

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 57.76  E-value: 1.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 160 ERRFNLTEQVRQLIMLSPAKLWTAQEIAGHLSIGTSTLRRRLQME-SQSYRQIVEEVRMSCALSQLQsTTLPIGEIALRC 238
Cdd:COG2169   80 PPRADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHtGVTPKAYARARRLLRARQLLQ-TGLSVTDAAYAA 158

                         90       100
                 ....*....|....*....|....
gi 740854203 239 GYLSGSRFTARFRQHYGCLPKQVR 262
Cdd:COG2169  159 GFGSLSRFYEAFKKLLGMTPSAYR 182
ftrA PRK09393
transcriptional activator FtrA; Provisional
 164-262 9.47e-05

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 43.03  E-value: 9.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 164 NLTEQVRQlimlSPAKLWTAQEIAGHLSIGTSTLRRRLQ--MESQSYRQIVEEvRMSCALSQLQSTTLPIGEIALRCGYL 241
Cdd:PRK09393 222 PLIDWMRA----HLAEPHTVASLAARAAMSPRTFLRRFEaaTGMTPAEWLLRE-RLARARDLLESSALSIDQIAERAGFG 296

                         90       100
                 ....*....|....*....|.
gi 740854203 242 SGSRFTARFRQHYGCLPKQVR 262
Cdd:PRK09393 297 SEESLRHHFRRRAATSPAAYR 317
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
167-262 1.80e-04

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 41.88  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 167 EQVRQLIMLSPAKLwtaqeiaGHL---SIGTSTLRRRlqmesqsyrqivEEVRMSCALSQLQSTTLPIGEIALRCGYLSG 243
Cdd:PRK10572 203 ESVAQHVCLSPSRL-------AHLfrqQLGISVLRWR------------EDQRISRAKLLLQTTRMPIATIGRNVGYDDQ 263

                         90
                 ....*....|....*....
gi 740854203 244 SRFTARFRQHYGCLPKQVR 262
Cdd:PRK10572 264 LYFSRVFKKCTGASPSEFR 282
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 221-262 6.63e-04

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 36.36  E-value: 6.63e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 740854203  221 LSQLQSTTLPIGEIALRCGYlSGSRFTARFRQHYGCLPKQVR 262
Cdd:pfam00165   1 LRENLSTNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYR 41
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
197-262 1.78e-03

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 38.88  E-value: 1.78e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740854203 197 LRRRLQMES-QSYRQIVEEVRMSCALSQLQSTTLPIGEIALRCGYLSGSRFTARFRQHYGCLPKQVR 262
Cdd:PRK13502 209 LRQQFRAQTgMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTPSQWR 275
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 40-262 2.43e-03

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 38.47  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203  40 GSKVIIQDDNRLVAGPGELIIIPANTPLEIInqpEQGAFRSDLLLLSASIIStfknnwvKDFPPAKLTSLC-----TPMS 114
Cdd:PRK09685  80 GHAIIEQDDRQVQLAAGDITLIDASRPCSIY---PQGLSEQISLLLPRELVE-------QYFPGQKPACAGrlsasLPMV 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 115 NglafMWESLLDAVRQDlpAKLQEHQAMGLLLAL-------LHDGVAGPLLIERRFnltEQVRQLI-------MLSPAkl 180
Cdd:PRK09685 150 Q----LSHRLLQQSMNG--PALSETESEALLEALiallrpaLHQRESVQPRRERQF---QKVVALIdqsiqeeILRPE-- 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 181 WtaqeIAGHLSIGTSTLRRRLQMESQSYRQIVEEVRMSCALSQLQSTTL--PIGEIALRCGYLSGSRFTARFRQHYGCLP 258
Cdd:PRK09685 219 W----IAGELGISVRSLYRLFAEQGLVVAQYIRNRRLDRCADDLRPAADdeKITSIAYKWGFSDSSHFSTAFKQRFGVSP 294


                 ....
gi 740854203 259 KQVR 262
Cdd:PRK09685 295 GEYR 298
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
184-262 3.62e-03

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 38.12  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740854203 184 QEIAGHLSIGTSTLRRRLQ----MESQSYrqiVEEVRMSCALSQLQSTTLPIGEIALRCGYLSGSRFTARFRQHYGCLPK 259
Cdd:PRK13503 191 EALADQFSLSLRTLHRQLKqqtgLTPQRY---LNRLRLLKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPR 267


                 ...
gi 740854203 260 QVR 262
Cdd:PRK13503 268 DIR 270
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 20-71 7.62e-03

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 34.54  E-value: 7.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 740854203   20 HLHRlhqvklFSAAICHITQGSKVIIQDDNRLVAGPGELIIIPANTPLEIIN 71
Cdd:pfam07883  14 HRHP------GEDEFFYVLEGEGELTVDGEEVVLKAGDSVYFPAGVPHRFRN 59
cupin_YP766765-like cd20299
Rhizobium leguminosarum YP_766765.1 and related proteins, cupin domain; This family includes ...
 36-77 9.16e-03

Rhizobium leguminosarum YP_766765.1 and related proteins, cupin domain; This family includes mostly bacterial proteins homologous to Rhizobium leguminosarum YP_766765.1, a protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380433 [Multi-domain]  Cd Length: 90  Bit Score: 34.57  E-value: 9.16e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 740854203  36 HITQGSKVIIQDDNRLVAGPGELIIIPANTPLEIINQPEQGA 77
Cdd:cd20299   42 VVLEGELTVTTDGEEVVLGPGDSCYIPPGETRSIDNRTNGPA 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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