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Conserved domains on  [gi|740851728|ref|WP_038636981|]
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MULTISPECIES: threonine/serine exporter [Citrobacter]

Protein Classification

threonine/serine exporter family protein( domain architecture ID 10013372)

threonine/serine exporter similar to ThrE, a membrane protein involved in the export of threonine and serine

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK09917 PRK09917
threonine/serine exporter;
1-157 1.86e-98

threonine/serine exporter;


:

Pssm-ID: 182143  Cd Length: 157  Bit Score: 280.12  E-value: 1.86e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851728   1 MGVIDFILALIQDMILSAIPALGFAMVFNVPHRALPWCALLGALGHGSRMVMMSAGFNIEWSTFMASLLIGCIGIQWSRW 80
Cdd:PRK09917   1 MGVIEFLLALAQDMILAAIPAVGFAMVFNVPVRALRWCALLGAIGHGSRMLMMTSGLNIEWSTFMASMLVGTIGIQWSRW 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740851728  81 YLAHPKVFTVAAVIPMFPGISAYTAMISAVKIGHFGYSEALMITLLTNFLKASSIVGALSIGLSVPGLWLYRKRPRV 157
Cdd:PRK09917  81 YLAHPKVFTVAAVIPMFPGISAYTAMISAVKISHLGYSEPLMITLLTNFLKASSIVGALSIGLSLPGLWLYRKRPRV 157
 
Name Accession Description Interval E-value
PRK09917 PRK09917
threonine/serine exporter;
1-157 1.86e-98

threonine/serine exporter;


Pssm-ID: 182143  Cd Length: 157  Bit Score: 280.12  E-value: 1.86e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851728   1 MGVIDFILALIQDMILSAIPALGFAMVFNVPHRALPWCALLGALGHGSRMVMMSAGFNIEWSTFMASLLIGCIGIQWSRW 80
Cdd:PRK09917   1 MGVIEFLLALAQDMILAAIPAVGFAMVFNVPVRALRWCALLGAIGHGSRMLMMTSGLNIEWSTFMASMLVGTIGIQWSRW 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740851728  81 YLAHPKVFTVAAVIPMFPGISAYTAMISAVKIGHFGYSEALMITLLTNFLKASSIVGALSIGLSVPGLWLYRKRPRV 157
Cdd:PRK09917  81 YLAHPKVFTVAAVIPMFPGISAYTAMISAVKISHLGYSEPLMITLLTNFLKASSIVGALSIGLSLPGLWLYRKRPRV 157
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
5-156 1.81e-36

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 123.00  E-value: 1.81e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851728   5 DFILALIQDMILSAIPALGFAMVFNVPHRALPWCALLGALGHGSRMVMMSAGFNIEWSTFMASLLIGCIGIQWSRWYLAH 84
Cdd:COG3610    1 DLLLPLLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLDLGLGPVLATFVAALVVGLLAELLARRLKAP 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740851728  85 PKVFTVAAVIPMFPGISAYTAMISAVkighfgysEALMITLLTNFLKASSIVGALSIGLSVPGLWLYRKRPR 156
Cdd:COG3610   81 ATVFTVPGIIPLVPGSGAYRAMYALV--------EGDYLAALSNGLEALLIAGALAAGLLLGSLLARPRRRK 144
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
13-148 6.80e-30

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 105.30  E-value: 6.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851728   13 DMILSAIPALGFAMVFNVPHRALPWCALLGALGHGSRMVMMSAGFNIEWSTFMASLLIGCIGIQWSRWYLAHPKVFTVAA 92
Cdd:pfam12821   1 QLIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPG 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 740851728   93 VIPMFPGISAYTAMISAVKighFGYSEAlmitlLTNFLKASSIVGALSIGLSVPGL 148
Cdd:pfam12821  81 IIPLVPGGGAYNTMYYLVQ---GNYALA-----VSYGLETLFIAGAIALGLVLVSL 128
 
Name Accession Description Interval E-value
PRK09917 PRK09917
threonine/serine exporter;
1-157 1.86e-98

threonine/serine exporter;


Pssm-ID: 182143  Cd Length: 157  Bit Score: 280.12  E-value: 1.86e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851728   1 MGVIDFILALIQDMILSAIPALGFAMVFNVPHRALPWCALLGALGHGSRMVMMSAGFNIEWSTFMASLLIGCIGIQWSRW 80
Cdd:PRK09917   1 MGVIEFLLALAQDMILAAIPAVGFAMVFNVPVRALRWCALLGAIGHGSRMLMMTSGLNIEWSTFMASMLVGTIGIQWSRW 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740851728  81 YLAHPKVFTVAAVIPMFPGISAYTAMISAVKIGHFGYSEALMITLLTNFLKASSIVGALSIGLSVPGLWLYRKRPRV 157
Cdd:PRK09917  81 YLAHPKVFTVAAVIPMFPGISAYTAMISAVKISHLGYSEPLMITLLTNFLKASSIVGALSIGLSLPGLWLYRKRPRV 157
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
5-156 1.81e-36

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 123.00  E-value: 1.81e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851728   5 DFILALIQDMILSAIPALGFAMVFNVPHRALPWCALLGALGHGSRMVMMSAGFNIEWSTFMASLLIGCIGIQWSRWYLAH 84
Cdd:COG3610    1 DLLLPLLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLDLGLGPVLATFVAALVVGLLAELLARRLKAP 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740851728  85 PKVFTVAAVIPMFPGISAYTAMISAVkighfgysEALMITLLTNFLKASSIVGALSIGLSVPGLWLYRKRPR 156
Cdd:COG3610   81 ATVFTVPGIIPLVPGSGAYRAMYALV--------EGDYLAALSNGLEALLIAGALAAGLLLGSLLARPRRRK 144
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
13-148 6.80e-30

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 105.30  E-value: 6.80e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851728   13 DMILSAIPALGFAMVFNVPHRALPWCALLGALGHGSRMVMMSAGFNIEWSTFMASLLIGCIGIQWSRWYLAHPKVFTVAA 92
Cdd:pfam12821   1 QLIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVYLLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVPG 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 740851728   93 VIPMFPGISAYTAMISAVKighFGYSEAlmitlLTNFLKASSIVGALSIGLSVPGL 148
Cdd:pfam12821  81 IIPLVPGGGAYNTMYYLVQ---GNYALA-----VSYGLETLFIAGAIALGLVLVSL 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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