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Conserved domains on  [gi|740851425|ref|WP_038636678|]
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MULTISPECIES: DotU family type IV/VI secretion system protein [Citrobacter]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DotU super family cl43873
Type VI protein secretion system component TssL/VasF/DotU [Intracellular trafficking, ...
 35-144 3.65e-19

Type VI protein secretion system component TssL/VasF/DotU [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG3455:

Pssm-ID: 442678 [Multi-domain]  Cd Length: 233  Bit Score: 83.10  E-value: 3.65e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851425  35 PDELHteafEYASQAVAEYNRRLiRELGTPfQQQIDDAVYALVALIDESVLYGDWPALSLWQSCPLEYHLWQTHSAGDLI 114
Cdd:COG3455   39 PAALR----QRLVEEIRRFERRL-RAAGYS-PEDIEAARYALCALLDEAVLNTPWGGRSEWSRHPLQSTFFNETWGGEKF 112

                         90       100       110
                 ....*....|....*....|....*....|
gi 740851425 115 PHKITALLNERSPgQRDLAALYLRCLTLGF 144
Cdd:COG3455  113 FELLERLLQEPAA-HLDLLELYYLCLLLGF 141
 
Name Accession Description Interval E-value
DotU COG3455
Type VI protein secretion system component TssL/VasF/DotU [Intracellular trafficking, ...
 35-144 3.65e-19

Type VI protein secretion system component TssL/VasF/DotU [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442678 [Multi-domain]  Cd Length: 233  Bit Score: 83.10  E-value: 3.65e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851425  35 PDELHteafEYASQAVAEYNRRLiRELGTPfQQQIDDAVYALVALIDESVLYGDWPALSLWQSCPLEYHLWQTHSAGDLI 114
Cdd:COG3455   39 PAALR----QRLVEEIRRFERRL-RAAGYS-PEDIEAARYALCALLDEAVLNTPWGGRSEWSRHPLQSTFFNETWGGEKF 112

                         90       100       110
                 ....*....|....*....|....*....|
gi 740851425 115 PHKITALLNERSPgQRDLAALYLRCLTLGF 144
Cdd:COG3455  113 FELLERLLQEPAA-HLDLLELYYLCLLLGF 141
IV_VI_DotU TIGR03349
type IV / VI secretion system protein, DotU family; At least two families of proteins, often ...
 55-199 3.69e-15

type IV / VI secretion system protein, DotU family; At least two families of proteins, often encoded by adjacent genes, show sequence similarity due to homology between type IV secretion systems and type VI secretion systems. One is the IcmF family (TIGR03348). The other is the family described by this model. Members include DotU from the Legionella pneumophila type IV secretion system. Many of the members of this protein family from type VI secretion systems have an additional C-terminal domain with OmpA/MotB homology. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274532 [Multi-domain]  Cd Length: 183  Bit Score: 71.15  E-value: 3.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851425   55 RRLIRELGTPfQQQIDDAVYALVALIDESVLYGDWPALSLWQSCPLEYHLWQTHSAGDliphKITALLNE--RSPGQ-RD 131
Cdd:TIGR03349  29 ERRLRAAGYS-SEDIEAARYALCALLDEAVLNTPWGGRSVWSRQPLLSRFHNETWGGE----KFFERLERllADPAEhLD 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740851425  132 LAALYLRCLTLGF-GSRRDDFDPQAH--QETCQL---LWHFAFQHDARFSDIAQRMesaalgTPLQLPAHRRLP 199
Cdd:TIGR03349 104 LLELYYLCLSLGFeGKYRVEEDGREQleALRDRLyrlLRGARGPVPPALSPHWQGP------AAARRRLRRYVP 171
DotU pfam09850
Type VI secretion system protein DotU; DotU is a family of Gram-negative bacterial proteins ...
 50-200 4.35e-15

Type VI secretion system protein DotU; DotU is a family of Gram-negative bacterial proteins that form part of the membrane-joining complex of the type VI secretion system. DotU binds tightly to IcmF and together they are tethered to the inner membrane at one end and the peptidoglycan layer at the other; they interact with Lip1 which then tethers the peptidoglycan layer to the outer membrane.


Pssm-ID: 430877 [Multi-domain]  Cd Length: 205  Bit Score: 71.56  E-value: 4.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851425   50 VAEYNRRLIRELGTpFQQ----------QIDDAVYALVALIDESVLYGDWPALSLWQSCPLEYHLWQTHSAGDLIPHKIT 119
Cdd:pfam09850  25 AAALRERLVAELRA-FEQearaagysaeDIEAARYALCAFLDEAVLNTPWGGRSEWARRPLQSRFFGETWGGEKFFDRLD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851425  120 ALLnERSPGQRDLAALYLRCLTLGF-GSRRDDFDPQAhqetcqllwhfafQHDARFSDIAQRMESAALGTPLQLPAHRRL 198
Cdd:pfam09850 104 RLL-EDPAENLDLLELYYLCLSLGFeGRYRVEPDGEA-------------ELEALRQRLYQQIRRLRGEAPAALSPHWQP 169


                  ..
gi 740851425  199 PD 200
Cdd:pfam09850 170 GV 171
 
Name Accession Description Interval E-value
DotU COG3455
Type VI protein secretion system component TssL/VasF/DotU [Intracellular trafficking, ...
 35-144 3.65e-19

Type VI protein secretion system component TssL/VasF/DotU [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 442678 [Multi-domain]  Cd Length: 233  Bit Score: 83.10  E-value: 3.65e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851425  35 PDELHteafEYASQAVAEYNRRLiRELGTPfQQQIDDAVYALVALIDESVLYGDWPALSLWQSCPLEYHLWQTHSAGDLI 114
Cdd:COG3455   39 PAALR----QRLVEEIRRFERRL-RAAGYS-PEDIEAARYALCALLDEAVLNTPWGGRSEWSRHPLQSTFFNETWGGEKF 112

                         90       100       110
                 ....*....|....*....|....*....|
gi 740851425 115 PHKITALLNERSPgQRDLAALYLRCLTLGF 144
Cdd:COG3455  113 FELLERLLQEPAA-HLDLLELYYLCLLLGF 141
IV_VI_DotU TIGR03349
type IV / VI secretion system protein, DotU family; At least two families of proteins, often ...
 55-199 3.69e-15

type IV / VI secretion system protein, DotU family; At least two families of proteins, often encoded by adjacent genes, show sequence similarity due to homology between type IV secretion systems and type VI secretion systems. One is the IcmF family (TIGR03348). The other is the family described by this model. Members include DotU from the Legionella pneumophila type IV secretion system. Many of the members of this protein family from type VI secretion systems have an additional C-terminal domain with OmpA/MotB homology. [Protein fate, Protein and peptide secretion and trafficking, Cellular processes, Pathogenesis]


Pssm-ID: 274532 [Multi-domain]  Cd Length: 183  Bit Score: 71.15  E-value: 3.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851425   55 RRLIRELGTPfQQQIDDAVYALVALIDESVLYGDWPALSLWQSCPLEYHLWQTHSAGDliphKITALLNE--RSPGQ-RD 131
Cdd:TIGR03349  29 ERRLRAAGYS-SEDIEAARYALCALLDEAVLNTPWGGRSVWSRQPLLSRFHNETWGGE----KFFERLERllADPAEhLD 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740851425  132 LAALYLRCLTLGF-GSRRDDFDPQAH--QETCQL---LWHFAFQHDARFSDIAQRMesaalgTPLQLPAHRRLP 199
Cdd:TIGR03349 104 LLELYYLCLSLGFeGKYRVEEDGREQleALRDRLyrlLRGARGPVPPALSPHWQGP------AAARRRLRRYVP 171
DotU pfam09850
Type VI secretion system protein DotU; DotU is a family of Gram-negative bacterial proteins ...
 50-200 4.35e-15

Type VI secretion system protein DotU; DotU is a family of Gram-negative bacterial proteins that form part of the membrane-joining complex of the type VI secretion system. DotU binds tightly to IcmF and together they are tethered to the inner membrane at one end and the peptidoglycan layer at the other; they interact with Lip1 which then tethers the peptidoglycan layer to the outer membrane.


Pssm-ID: 430877 [Multi-domain]  Cd Length: 205  Bit Score: 71.56  E-value: 4.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851425   50 VAEYNRRLIRELGTpFQQ----------QIDDAVYALVALIDESVLYGDWPALSLWQSCPLEYHLWQTHSAGDLIPHKIT 119
Cdd:pfam09850  25 AAALRERLVAELRA-FEQearaagysaeDIEAARYALCAFLDEAVLNTPWGGRSEWARRPLQSRFFGETWGGEKFFDRLD 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740851425  120 ALLnERSPGQRDLAALYLRCLTLGF-GSRRDDFDPQAhqetcqllwhfafQHDARFSDIAQRMESAALGTPLQLPAHRRL 198
Cdd:pfam09850 104 RLL-EDPAENLDLLELYYLCLSLGFeGRYRVEPDGEA-------------ELEALRQRLYQQIRRLRGEAPAALSPHWQP 169


                  ..
gi 740851425  199 PD 200
Cdd:pfam09850 170 GV 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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