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Conserved domains on  [gi|740694750|ref|WP_038480039|]
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MULTISPECIES: type II toxin-antitoxin system CcdA family antitoxin [Cedecea]

Protein Classification

similar to antitoxin VapB3( domain architecture ID 10009188)

protein similar to antitoxin VapB3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5302 COG5302
Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [Mobilome: ...
 1-80 6.04e-32

Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [Mobilome: prophages, transposons];


:

Pssm-ID: 444102  Cd Length: 80  Bit Score: 105.74  E-value: 6.04e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740694750  1 MPASASIRVKKTVTVTLEPELIQEARAAGINLSQTLRNALKAEIKEIEAARWKKENEAAIDYLNQLTEENGLLSDTYRTF 80
Cdd:COG5302   1 MPTTQSQAPKKATNVSLDADLLAEARALGINLSAALEEALAEAVREAKAERWLEENAEAIEAYNRFVEEHGLPLDEYRSF 80
 
Name Accession Description Interval E-value
COG5302 COG5302
Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [Mobilome: ...
 1-80 6.04e-32

Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [Mobilome: prophages, transposons];


Pssm-ID: 444102  Cd Length: 80  Bit Score: 105.74  E-value: 6.04e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740694750  1 MPASASIRVKKTVTVTLEPELIQEARAAGINLSQTLRNALKAEIKEIEAARWKKENEAAIDYLNQLTEENGLLSDTYRTF 80
Cdd:COG5302   1 MPTTQSQAPKKATNVSLDADLLAEARALGINLSAALEEALAEAVREAKAERWLEENAEAIEAYNRFVEEHGLPLDEYRSF 80
CcdA pfam07362
Post-segregation antitoxin CcdA; This family consists of several Enterobacterial ...
 10-80 9.20e-24

Post-segregation antitoxin CcdA; This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein.


Pssm-ID: 429428  Cd Length: 71  Bit Score: 84.95  E-value: 9.20e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740694750  10 KKTVTVTLEPELIQEARAAGINLSQTLRNALKAEIKEIEAARWKKENEAAIDYLNQLTEENGLLSDTYRTF 80
Cdd:pfam07362  1 KKATNLSLNADLLAEARALGINLSATLEEALAEEVRRRKAERWKEENREAIEAYNRFIEKHGLFADEYRSF 71
PRK13710 PRK13710
type II toxin-antitoxin system antitoxin CcdA;
9-78 1.29e-07

type II toxin-antitoxin system antitoxin CcdA;


Pssm-ID: 184266  Cd Length: 72  Bit Score: 44.11  E-value: 1.29e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740694750  9 VKKTVTVTLEPELIQEARAAGINLSQTLRNALKAEIKEIEAARWKKENEAAIDYLNQLTEENGLLSDTYR 78
Cdd:PRK13710  1 MKQRITVTVDSDSYQLLKAADVNISGLVNTAMQNEARRLRAERWKAENREGMAEVARFIEMNGSFADENR 70
 
Name Accession Description Interval E-value
COG5302 COG5302
Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [Mobilome: ...
 1-80 6.04e-32

Post-segregation antitoxin (ccd killing mechanism protein) encoded by the F plasmid [Mobilome: prophages, transposons];


Pssm-ID: 444102  Cd Length: 80  Bit Score: 105.74  E-value: 6.04e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740694750  1 MPASASIRVKKTVTVTLEPELIQEARAAGINLSQTLRNALKAEIKEIEAARWKKENEAAIDYLNQLTEENGLLSDTYRTF 80
Cdd:COG5302   1 MPTTQSQAPKKATNVSLDADLLAEARALGINLSAALEEALAEAVREAKAERWLEENAEAIEAYNRFVEEHGLPLDEYRSF 80
CcdA pfam07362
Post-segregation antitoxin CcdA; This family consists of several Enterobacterial ...
 10-80 9.20e-24

Post-segregation antitoxin CcdA; This family consists of several Enterobacterial post-segregation antitoxin CcdA proteins. The F plasmid-carried bacterial toxin, the CcdB protein, is known to act on DNA gyrase in two different ways. CcdB poisons the gyrase-DNA complex, blocking the passage of polymerases and leading to double-strand breakage of the DNA. Alternatively, in cells that overexpress CcdB, the A subunit of DNA gyrase (GyrA) has been found as an inactive complex with CcdB. Both poisoning and inactivation can be prevented and reversed in the presence of the F plasmid-encoded antidote, the CcdA protein.


Pssm-ID: 429428  Cd Length: 71  Bit Score: 84.95  E-value: 9.20e-24
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740694750  10 KKTVTVTLEPELIQEARAAGINLSQTLRNALKAEIKEIEAARWKKENEAAIDYLNQLTEENGLLSDTYRTF 80
Cdd:pfam07362  1 KKATNLSLNADLLAEARALGINLSATLEEALAEEVRRRKAERWKEENREAIEAYNRFIEKHGLFADEYRSF 71
PRK13710 PRK13710
type II toxin-antitoxin system antitoxin CcdA;
9-78 1.29e-07

type II toxin-antitoxin system antitoxin CcdA;


Pssm-ID: 184266  Cd Length: 72  Bit Score: 44.11  E-value: 1.29e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740694750  9 VKKTVTVTLEPELIQEARAAGINLSQTLRNALKAEIKEIEAARWKKENEAAIDYLNQLTEENGLLSDTYR 78
Cdd:PRK13710  1 MKQRITVTVDSDSYQLLKAADVNISGLVNTAMQNEARRLRAERWKAENREGMAEVARFIEMNGSFADENR 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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