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Conserved domains on  [gi|740647302|ref|WP_038432748|]
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MFS transporter [Klebsiella pneumoniae]

Protein Classification

MFS transporter( domain architecture ID 13022956)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 25-415 5.99e-57

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 192.39  E-value: 5.99e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  25 IMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCAL 104
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 105 ANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINflpg 184
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN---- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 185 tlalllavralprdairmqapfdtVGAILSALLLGSTimaanslqnatsqfgslcwmalaalsgmafiwqirrtghpllp 264
Cdd:cd17321  157 ------------------------VPIGLVALLLART------------------------------------------- 169

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 265 psmfknerFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGL 344
Cdd:cd17321  170 --------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL 241

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740647302 345 VIFVVGLILLATLPARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:cd17321  242 LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 25-415 5.99e-57

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 192.39  E-value: 5.99e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  25 IMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCAL 104
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 105 ANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINflpg 184
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN---- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 185 tlalllavralprdairmqapfdtVGAILSALLLGSTimaanslqnatsqfgslcwmalaalsgmafiwqirrtghpllp 264
Cdd:cd17321  157 ------------------------VPIGLVALLLART------------------------------------------- 169

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 265 psmfknerFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGL 344
Cdd:cd17321  170 --------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL 241

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740647302 345 VIFVVGLILLATLPARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:cd17321  242 LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 24-415 1.29e-50

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 178.73  E-value: 1.29e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   24 AIMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCA 103
Cdd:TIGR00711   6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  104 LANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLP 183
Cdd:TIGR00711  86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  184 GTLALLLAVRALPRDAIRMQAPFDTVGAILSALLLGstimaanSLQNATSQFGSLCWMA---------LAALSGMAFIWQ 254
Cdd:TIGR00711 166 GIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLG-------SLLYGLSEGPERGWFDsneililsiTGLVAIIAFVVW 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  255 IRRTGHPLLPPSMFKNERFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTI 334
Cdd:TIGR00711 239 ELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKI 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  335 SAPAISTLGLVIFVVGLILLA-TLPARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQC 413
Cdd:TIGR00711 319 DPRKLVTIGLILYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGS 398


                  ..
gi 740647302  414 LG 415
Cdd:TIGR00711 399 IG 400
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-412 4.19e-34

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 130.86  E-value: 4.19e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  14 PGPARARVMAAIMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLT 93
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  94 TFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSW 173
Cdd:COG2814   84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 174 QWLFAINFLPGtlalllavralprdairmqapfdtvgaiLSALLLGSTIMAANSLQNATSQFGSLcwmalaalsgmafiw 253
Cdd:COG2814  164 RWVFLVNAVLA----------------------------LLALLLLLRLLPESRPAARARLRGSL--------------- 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 254 qirrtghpllpPSMFKNERFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADT 333
Cdd:COG2814  201 -----------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740647302 334 ISAPAISTLGLVIFVVGLILLATLparPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQ 412
Cdd:COG2814  270 FGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
PRK10504 PRK10504
putative transporter; Provisional
 31-319 8.54e-22

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 97.49  E-value: 8.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  31 MGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEV 110
Cdd:PRK10504  21 MQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 111 LIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLPGTLALLL 190
Cdd:PRK10504 101 LLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 191 AVRALPRDAIRMQApFDTVGAILSALLLGSTIMAansLQNATSQFGSLCWMALAALSGMA----FIWQIRRTGHPLLPPS 266
Cdd:PRK10504 181 TLMLMPNYTMQTRR-FDLSGFLLLAVGMATLTLA---LDGSKGLGLSPLAIAGLVAVGVValllYLLHARNNNRALFSLK 256

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 740647302 267 MFKNERFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLG 319
Cdd:PRK10504 257 LFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLG 309
MFS_1 pfam07690
Major Facilitator Superfamily;
25-415 1.17e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 89.78  E-value: 1.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   25 IMTTTLMGVFDGTMINIALPS-MAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCA 103
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  104 LANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLP 183
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  184 GTLALLLAVRALPRDAIRMQAPFDTVGAILSALLlgstimaanslqnatsqfgslcwmalaalsgmafiwqirrtghpll 263
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW---------------------------------------------- 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  264 ppSMFKNERFTLAAFTSMVAFVSQGITFIALPfLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLG 343
Cdd:pfam07690 195 --KALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA 271

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740647302  344 LVIFVVGLILLATLPARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:pfam07690 272 LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 25-415 5.99e-57

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 192.39  E-value: 5.99e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  25 IMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCAL 104
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 105 ANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINflpg 184
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLIN---- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 185 tlalllavralprdairmqapfdtVGAILSALLLGSTimaanslqnatsqfgslcwmalaalsgmafiwqirrtghpllp 264
Cdd:cd17321  157 ------------------------VPIGLVALLLART------------------------------------------- 169

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 265 psmfknerFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGL 344
Cdd:cd17321  170 --------FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGL 241

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740647302 345 VIFVVGLILLATLPARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:cd17321  242 LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALG 312
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 24-415 1.29e-50

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 178.73  E-value: 1.29e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   24 AIMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCA 103
Cdd:TIGR00711   6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  104 LANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLP 183
Cdd:TIGR00711  86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  184 GTLALLLAVRALPRDAIRMQAPFDTVGAILSALLLGstimaanSLQNATSQFGSLCWMA---------LAALSGMAFIWQ 254
Cdd:TIGR00711 166 GIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLG-------SLLYGLSEGPERGWFDsneililsiTGLVAIIAFVVW 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  255 IRRTGHPLLPPSMFKNERFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTI 334
Cdd:TIGR00711 239 ELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKI 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  335 SAPAISTLGLVIFVVGLILLA-TLPARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQC 413
Cdd:TIGR00711 319 DPRKLVTIGLILYAVGFYWRAfTFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGS 398


                  ..
gi 740647302  414 LG 415
Cdd:TIGR00711 399 IG 400
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 25-415 1.88e-41

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 151.57  E-value: 1.88e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  25 IMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCAL 104
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 105 ANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLPG 184
Cdd:cd17503   81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 185 tlalllavralprdairmqapfdtvgaILSALLLgstimaanslqnatsqfgslcwmalaalsgmafiwqirrtghPLLP 264
Cdd:cd17503  161 ---------------------------ILALLLA------------------------------------------PLLD 171

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 265 PSMFKNERFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGL 344
Cdd:cd17503  172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740647302 345 VIFVVGLILLATLPARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:cd17503  252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIG 322
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
14-412 4.19e-34

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 130.86  E-value: 4.19e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  14 PGPARARVMAAIMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLT 93
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  94 TFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSW 173
Cdd:COG2814   84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 174 QWLFAINFLPGtlalllavralprdairmqapfdtvgaiLSALLLGSTIMAANSLQNATSQFGSLcwmalaalsgmafiw 253
Cdd:COG2814  164 RWVFLVNAVLA----------------------------LLALLLLLRLLPESRPAARARLRGSL--------------- 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 254 qirrtghpllpPSMFKNERFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADT 333
Cdd:COG2814  201 -----------RELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740647302 334 ISAPAISTLGLVIFVVGLILLATLparPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQ 412
Cdd:COG2814  270 FGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 25-415 1.04e-28

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 115.74  E-value: 1.04e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  25 IMTTTLMGVFDGTMINIALPSMAQEMQVPASIAvWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCAL 104
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 105 ANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINfLPg 184
Cdd:cd17502   80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYIN-LP- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 185 tlalllavralprdairmqapfdtVGAIlsALLLGSTIMAAnslqnatsqfgslcwMALAALSGMAFIwqirrtghpllp 264
Cdd:cd17502  158 ------------------------IGGL--ALALLRTILLS---------------SIFGFLFGGALF------------ 184

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 265 psmfknerftlaaftsmvafvsqgITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRW-ADTISAPAISTLG 343
Cdd:cd17502  185 ------------------------GLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALiSKTGRYKPLIVIG 240

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740647302 344 LVIFVVGLILLATLPARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:cd17502  241 TILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLG 312
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 13-298 2.80e-28

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 113.37  E-value: 2.80e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  13 LPGPARARVMAAIMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGL 92
Cdd:COG0477    7 APTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  93 TTFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLS 172
Cdd:COG0477   87 LLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 173 WQWLFAINFLPGTLALLLAVRALPRDAIRMQAPFDTVGAILSALLLGSTIMAANSLQNATSQFGSLCWMALAALSGMAFI 252
Cdd:COG0477  167 WRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALL 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 740647302 253 WQIRRTGHPLLPPSMFKNERFTLAAFTSMVAFVSQGITFIALPFLF 298
Cdd:COG0477  247 LLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLA 292
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 37-411 3.81e-27

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 111.90  E-value: 3.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  37 TMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRV 116
Cdd:cd17320   16 DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 117 LQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLpgtlalllavralp 196
Cdd:cd17320   96 LQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLAL-------------- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 197 rdairmqapFDTVGAILSALLLGSTIMAANSLQNATSQFGSLcwmalaalsgmafiwqirrtghpllpPSMFKNERFTLA 276
Cdd:cd17320  162 ---------LGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAY--------------------------KRVLKNRRFLGY 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 277 AFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGLVIFVVG--LILL 354
Cdd:cd17320  207 ALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAalVLLL 286

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 740647302 355 ATLPARPSMWDICLRSLVCGIGFGcFQSPNNREMLSNVIREHASYASGVLSIMRTFG 411
Cdd:cd17320  287 AALLGGLSLWPLVAPLFLIFFGFG-LIFPNATSLALEPFPHVAGTASALLGFLQFLI 342
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 37-415 2.80e-24

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 103.81  E-value: 2.80e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  37 TMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRV 116
Cdd:cd17504   13 TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 117 LQGIGGaATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFlpgtlalllavralp 196
Cdd:cd17504   93 LQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAA--------------- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 197 rdairmqapfdtVGAILSALLLgstimaanslqnatsqfgslcwmalaalsgmafiwqirrtghPLLPPSMFKNERFTLA 276
Cdd:cd17504  157 ------------PVAVLLAALV------------------------------------------PLIDLRLLRRRNVLLA 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 277 AFTSMVAFVSQGITFIALPFLFQSE----YGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGLVIFVVGLI 352
Cdd:cd17504  183 NITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLL 262

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 740647302 353 LLATLPArpSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:cd17504  263 LLALLHS--SLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIG 323
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 30-355 4.20e-23

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 100.54  E-value: 4.20e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   30 LMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPE 109
Cdd:TIGR00710  15 ILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  110 VLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLPGtlall 189
Cdd:TIGR00710  95 TLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSLAG----- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  190 lavralprdairmqapfdTVGAILSALLLGSTIMAANSLQNAT--SQFGSLcwmalaalsgmafiwqirrtghpllppsm 267
Cdd:TIGR00710 170 ------------------ILLSALIFFILPETLPYEARIQISTyfETFLLL----------------------------- 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  268 FKNERFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGLVIF 347
Cdd:TIGR00710 203 LKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILF 282


                  ....*...
gi 740647302  348 VVGLILLA 355
Cdd:TIGR00710 283 AVSAVLLE 290
PRK10504 PRK10504
putative transporter; Provisional
 31-319 8.54e-22

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 97.49  E-value: 8.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  31 MGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEV 110
Cdd:PRK10504  21 MQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 111 LIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLPGTLALLL 190
Cdd:PRK10504 101 LLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGAIA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 191 AVRALPRDAIRMQApFDTVGAILSALLLGSTIMAansLQNATSQFGSLCWMALAALSGMA----FIWQIRRTGHPLLPPS 266
Cdd:PRK10504 181 TLMLMPNYTMQTRR-FDLSGFLLLAVGMATLTLA---LDGSKGLGLSPLAIAGLVAVGVValllYLLHARNNNRALFSLK 256

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 740647302 267 MFKNERFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLG 319
Cdd:PRK10504 257 LFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLG 309
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 27-415 1.25e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 93.02  E-value: 1.25e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  27 TTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALAN 106
Cdd:cd17325    3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 107 KPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAInflpgtl 186
Cdd:cd17325   83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV------- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 187 alllavralprdairmQAPFDTVGAILSALLLGSTIMAANSLQNATSQFGSLCWMalaalsgmafiwqirrtghpllpps 266
Cdd:cd17325  156 ----------------CAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRL------------------------- 194

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 267 MFKNERFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGLVI 346
Cdd:cd17325  195 LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLL 274

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740647302 347 FVVGLILlatLPARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:cd17325  275 SAVALLL---LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
MFS_1 pfam07690
Major Facilitator Superfamily;
25-415 1.17e-19

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 89.78  E-value: 1.17e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   25 IMTTTLMGVFDGTMINIALPS-MAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCA 103
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  104 LANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLP 183
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  184 GTLALLLAVRALPRDAIRMQAPFDTVGAILSALLlgstimaanslqnatsqfgslcwmalaalsgmafiwqirrtghpll 263
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW---------------------------------------------- 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  264 ppSMFKNERFTLAAFTSMVAFVSQGITFIALPfLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLG 343
Cdd:pfam07690 195 --KALLRDPVLWLLLALLLFGFAFFGLLTYLP-LYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA 271

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740647302  344 LVIFVVGLILLATLPARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:pfam07690 272 LLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 29-415 4.80e-19

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 88.40  E-value: 4.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  29 TLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKP 108
Cdd:cd17474    8 TLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 109 EVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGtILHTLSWQWLFAINFLpgtlal 188
Cdd:cd17474   88 ALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG-LLAAISWRYPFFLLAA------ 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 189 llavralprdairmqapfdtvgAILSALLLGSTIMAANSLQNATSQFgslcwmalAALSGMAFIwqirrtghpllppsmF 268
Cdd:cd17474  161 ----------------------LIPVAFLAILFLLPEPKEKAKSSSA--------TKLRDLKKA---------------L 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 269 KNERFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRW-ADTISAPAISTLGLVIF 347
Cdd:cd17474  196 RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLlKKRFGARRILVIGLLLY 275

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740647302 348 VVGLILLATLparPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:cd17474  276 ALSLLLLGFV---PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVG 340
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
13-184 1.46e-17

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 83.77  E-value: 1.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  13 LPGPARARVMAAIMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGL 92
Cdd:COG2271    3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  93 TTFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLS 172
Cdd:COG2271   83 LLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162

                        170
                 ....*....|..
gi 740647302 173 WQWLFAINFLPG 184
Cdd:COG2271  163 WRAAFLILGLPG 174
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 25-180 3.17e-16

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 79.93  E-value: 3.17e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  25 IMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCAL 104
Cdd:cd17323    4 ISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCAL 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 740647302 105 ANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAIN 180
Cdd:cd17323   84 APNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFL 159
PRK14995 PRK14995
SmvA family efflux MFS transporter;
35-357 1.84e-14

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 75.15  E-value: 1.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  35 DGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGM 114
Cdd:PRK14995  21 DATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIAT 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 115 RVLQGIGGAATLSIAPAILRSVF-PGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLPGTLALLLAVR 193
Cdd:PRK14995 101 RALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVMGLTAR 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 194 ALPRDAIRMQAPFDTVGAIlsaLLLGSTIMAANSLQNATSQFGSLCWMALAALSGMA----FIWQIRRTGHPLLPPSMFK 269
Cdd:PRK14995 181 YVPRQAGRRDQPLNLGHAL---MLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALllglFIRTQLAASRPMIDMRLFT 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 270 NERFTLAAFTSMVAFvsqgITFIALPFLFQSE----YGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGLV 345
Cdd:PRK14995 258 HRIILSGVVMAMTAM----ITLVGFELLMAQElqfvHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVATGGMA 333

                        330
                 ....*....|..
gi 740647302 346 IFVVGLILLATL 357
Cdd:PRK14995 334 LSALSFYGLAMT 345
2_A_01_02 TIGR00880
Multidrug resistance protein;
74-180 5.24e-14

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 68.83  E-value: 5.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   74 IFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLI 153
Cdd:TIGR00880  17 LSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLMSAGI 96

                          90       100
                  ....*....|....*....|....*..
gi 740647302  154 ASSSAIGPVLGGTILHTLSWQWLFAIN 180
Cdd:TIGR00880  97 ALGPLLGPPLGGVLAQFLGWRAPFLFL 123
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
42-177 2.00e-13

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 71.48  E-value: 2.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  42 ALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIG 121
Cdd:PRK11102  13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 740647302 122 GAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLF 177
Cdd:PRK11102  93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIF 148
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 43-384 6.98e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 69.89  E-value: 6.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  43 LPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIGG 122
Cdd:cd17324   22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAH 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 123 AATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAInflpgtlalllavralprdairm 202
Cdd:cd17324  102 GGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA----------------------- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 203 qapFDTVGAILSALLlgstimaanslqnatsqfgslcWMALAALSGMAfiwqIRRTGHPLLPPSMFKNERFTLAAFTSMV 282
Cdd:cd17324  159 ---IAVLALLAALLL----------------------WRLLPSLPPKK----PGSLGLLSSLLLLLRNPRLRLAYLITFL 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 283 AFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGLVIFVVGLILLATLparPS 362
Cdd:cd17324  210 LFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG---PS 286

                        330       340
                 ....*....|....*....|..
gi 740647302 363 MWDICLRSLVCGIGFGCFQSPN 384
Cdd:cd17324  287 PLLLLVGLVLWGLGFFAAHSAL 308
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 41-180 1.61e-11

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 65.36  E-value: 1.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  41 IALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGI 120
Cdd:cd17476   19 VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740647302 121 GGAATLSIAPAILRSVF-PGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAIN 180
Cdd:cd17476   99 GPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL 159
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 38-406 3.95e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 64.15  E-value: 3.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  38 MINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVL 117
Cdd:cd17489   14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 118 QGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAInflpgtlalllavralpr 197
Cdd:cd17489   94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIV------------------ 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 198 dairmqAPFDTVGAILSALLLGSTIMAANSLQNATSQFgslcwmalaalsgmafiwqirrtghpllpPSMFKNERFTLAA 277
Cdd:cd17489  156 ------AAVLALLALLLVFLVKDPPPVAAEEAEAGTRA-----------------------------FRRLVEKKVLPPA 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 278 FTSMVAFVSQG--ITFIAlpfLFQSEYGYSpvVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGLVIFVVGLILLA 355
Cdd:cd17489  201 LILFLASIAYGaiSTFLP---LYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLS 275

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 740647302 356 tlpARPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSI 406
Cdd:cd17489  276 ---FAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFI 323
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
18-378 5.86e-11

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 64.13  E-value: 5.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  18 RARVMAAIMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTL 97
Cdd:COG2223    3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  98 TSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLF 177
Cdd:COG2223   83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 178 AInflpgtlalllavralprdairmQAPFDTVGAILSALLLGSTimAANSLQNATSQFGSLcwmalaalsgmafiwqirr 257
Cdd:COG2223  163 LI-----------------------LGILLLVVAVLAWLFLRDP--PAGAAAAAKASLRDQ------------------- 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 258 tghpllpPSMFKNERFTLAAFTSMVAFVSqGITFIA-LPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISA 336
Cdd:COG2223  199 -------LEALRDPRFWLLSLLYFGTFGS-FIGFSSwLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG 270

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 740647302 337 PAISTLGLVIFVVGLILLATLParPSMWDICLRSLVCGIGFG 378
Cdd:COG2223  271 RRVLLIVFALMALGLLLLALAL--GSLWLFLVLFLLLGLALG 310
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 24-414 6.56e-11

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 63.75  E-value: 6.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  24 AIMTTTLMGVFDGTMINIALPSMAQEMQ-VPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGC 102
Cdd:cd17473    3 TLLLASTLTVMAGAAIAPALPAIAQHFVpNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 103 ALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGtILHTLSWQWLFAInFL 182
Cdd:cd17473   83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGG-ALAEIGWRAPFLV-YL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 183 PGTLALLLAVRALPRDAIRMQAPFDTVGAILSALLLGSTIMAAnslqnatsqfgslcwmalaalsgmafiwqirrtghpl 262
Cdd:cd17473  161 LALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIY------------------------------------- 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 263 lppsmfknerftLAAFTSMVAFVsqgITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTL 342
Cdd:cd17473  204 ------------FLAFLAMLLFY---VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI 268

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740647302 343 GLVIFVVGLILLATLparPSMWDICLRSLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCL 414
Cdd:cd17473  269 GFALMALGFLLLALA---SGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFL 337
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 31-357 2.68e-10

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 62.26  E-value: 2.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  31 MGVFDGTMINIALPSMAQEMQV---PASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANK 107
Cdd:cd06179    5 LAYFAQLFGVTLPAAVLPFIVAdlgPSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 108 PEVLIGMRVLQGIgGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHT--LSWQWLFAIN-FLPG 184
Cdd:cd06179   85 VNMLIGGQALIGI-GAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEAnaAGWRWIFYINaIFNA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 185 TLALLLAVRALPRDAIRMQAP--------FDTVGailSALLLGSTIMAANSLQNATSQFGS-----LCWMALAALSGMAF 251
Cdd:cd06179  164 LALILLFFFYHPPPRPQLHGSstrqklkrLDWVG---LFLLIAGLVLFLLGLSWGGNPYPWssahvIAPLVIGGVLLIAF 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 252 -IWQIRRTGHPLLPPSMFKNER-FTLAAFtsmVAFVSqGITFIALPFLFQSE----YGYSPVVSALLFTPWPLGIVLIAP 325
Cdd:cd06179  241 gLYEWKGTKDGLLPPRLLFRGRnFALILI---VAFVE-GMIFYSLNIFWPQQisllFTTDPLKAGLYQLPFGLGTLFGAI 316

                        330       340       350
                 ....*....|....*....|....*....|...
gi 740647302 326 HAGRWADTISAPAIS-TLGLVIFVVGLILLATL 357
Cdd:cd06179  317 LAGLLLTKIKHIKWQlVAGFVLFTAFLALLALI 349
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 34-415 4.89e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 60.90  E-value: 4.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  34 FDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIG 113
Cdd:cd06174   10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 114 MRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTIL--HTLSWQWLFAINFLPGTLALLLA 191
Cdd:cd06174   90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILL 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 192 VRALPRDAIRMQAPfdtvgailsalllgstimaaNSLQNATSQFGSLcwmalaalsgmafiwqirrtghpllpPSMFKNE 271
Cdd:cd06174  170 LLVVPDPPESARAK--------------------NEEASSKSVLKLL--------------------------KRVLKNP 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 272 RFTLAAFTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWAD-TISAPAISTLGLVIFVVG 350
Cdd:cd06174  204 GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALG 283

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740647302 351 LILLATLPARPSMWDIClrsLVCGIGFGCFQSPNNREMLSNVIREHASYASGVLSIMRTFGQCLG 415
Cdd:cd06174  284 LALLLLAPSLLLLLLLL---LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIG 345
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
38-179 5.77e-09

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 57.64  E-value: 5.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  38 MINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVL 117
Cdd:PRK15402  31 MIQPGMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFL 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740647302 118 QGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAI 179
Cdd:PRK15402 111 QGIGLCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVL 172
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 18-184 1.02e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 56.81  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  18 RARVMAAIMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTL 97
Cdd:cd17319    1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  98 TSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLF 177
Cdd:cd17319   81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160


                 ....*..
gi 740647302 178 AINFLPG 184
Cdd:cd17319  161 IIEGLLG 167
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
64-177 3.55e-08

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 55.41  E-value: 3.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  64 YLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLG 143
Cdd:PRK10473  47 YLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRA 126

                         90       100       110
                 ....*....|....*....|....*....|....
gi 740647302 144 RILGFHALLIASSSAIGPVLGGTILHTLSWQWLF 177
Cdd:PRK10473 127 KVLSLLNGITCIIPVLAPVLGHLIMLKFPWQSLF 160
emrD PRK11652
multidrug transporter EmrD;
37-178 4.49e-08

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 54.91  E-value: 4.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  37 TMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRV 116
Cdd:PRK11652  25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 740647302 117 LQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFA 178
Cdd:PRK11652 105 IQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYL 166
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 34-184 4.78e-08

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 54.88  E-value: 4.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  34 FDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIG 113
Cdd:cd17359   15 YDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFII 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 114 MRVLQGIG-GAATlSIAPAILRSVFPGRLLGRILGFHALLI--------ASSSAIGPVLGGTILHTLSWQWLFAINFLPG 184
Cdd:cd17359   95 ARIIGGLAvGGAS-ALVPMYIAEVAPAEIRGRLVSLNQLMIvfgqllayIVNYLIANAGGADWLGAEGWRWMLGLEAIPA 173
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 34-183 2.53e-07

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 52.66  E-value: 2.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  34 FDGTMINIALPSMAQEMQVPASIAVWFA---NGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEV 110
Cdd:cd17360   11 YDTGVISGALLYIKDDLGEVVLSTGWQElivSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEV 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740647302 111 LIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHT-LSWQWLFAINFLP 183
Cdd:cd17360   91 LIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLpGGWRWMLGLAAVP 164
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 74-184 2.99e-07

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 52.62  E-value: 2.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  74 IFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLI 153
Cdd:cd17328   53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAI 132

                         90       100       110
                 ....*....|....*....|....*....|..
gi 740647302 154 ASSSAIGPVLGGTI-LHTLSWQWLFAINFLPG 184
Cdd:cd17328  133 PLGSGLGYVVGGLVaQATGGWRWAFRVTGVLG 164
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
42-179 7.46e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 51.05  E-value: 7.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  42 ALPSMAQEMQVPASiavwfangyllAAAMTLAIFAA-----------LAARLGYRPVFLAGLTTFTLTSLGCALANKPEV 110
Cdd:PRK11043  28 AFKAIQADLQTSAS-----------AVSASLSLFLAgfalgqllwgpLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQ 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 740647302 111 LIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAI 179
Cdd:PRK11043  97 LLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFAT 165
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 34-184 1.35e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 50.28  E-value: 1.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  34 FDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIG 113
Cdd:cd17365   13 FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 740647302 114 MRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLPG 184
Cdd:cd17365   93 LRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPP 163
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 34-184 1.53e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.91  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  34 FDGTMINIALPSMAQE--MQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVL 111
Cdd:cd17316   13 YDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILL 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 740647302 112 IGMRVLQGIGGAATLSIAPAILRSVFP----GRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLPG 184
Cdd:cd17316   93 LVLRFLQGIGIGGEYPGASTYVAEFAPskrrGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPA 169
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 18-179 1.72e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 49.88  E-value: 1.72e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  18 RARVMAAIMTTTLMGVFDGTMINIALPSMAQEMQ--VPASIAVWFAnGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTF 95
Cdd:cd17325  197 RDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGglSPAQIGLLFG-AQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  96 TLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQW 175
Cdd:cd17325  276 AVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355


                 ....
gi 740647302 176 LFAI 179
Cdd:cd17325  356 PFLA 359
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
23-212 2.74e-06

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 49.44  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  23 AAIMTTTLMgvfDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAamtlaIFAALAARLGYRPVFLAGLTTFTLTSLGC 102
Cdd:PRK15403  27 AAYLTTDLI---QPGIINVVRDFNADVSLAPASVSLYLAGGMALQW-----LLGPLSDRIGRRPVLITGALIFTLACAAT 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 103 ALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFL 182
Cdd:PRK15403  99 LFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKVLFAIIAV 178

                        170       180       190
                 ....*....|....*....|....*....|
gi 740647302 183 PGTLALLLAVRALPRDAIRMQAPFDTVGAI 212
Cdd:PRK15403 179 MGLIAFVGLLLAMPETVKRGAVPFSAKSVL 208
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 65-253 5.61e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 48.32  E-value: 5.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  65 LLAAAMTLAIFAA------LAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFP 138
Cdd:cd17477   35 LVASAYYLGILLGsplvprLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALAT 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 139 GRLLGRILGFHALLIASSSAIGPVLGGTILhTLSWQW-----------LFAINFLPGTLALLLAVRALPRDAIRMQAPFD 207
Cdd:cd17477  115 NENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALPfliaavllllaLVPLLLTRRAAPEIEEAESISLRRLLRIAPLA 193

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 740647302 208 TVGAILSALLLGS--TIMAANSLQNATSQFGSLCWMALAALSGMAFIW 253
Cdd:cd17477  194 LLGAFVAGFLEGAfySLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQW 241
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 16-179 5.90e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 48.51  E-value: 5.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   16 PARARVMAAIMTTTLMGVFDG---TMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGL 92
Cdd:TIGR00895  10 PLSRYQWRAIILSFLIMLMDGydlAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSI 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   93 TTFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLS 172
Cdd:TIGR00895  90 LLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG 169


                  ....*..
gi 740647302  173 WQWLFAI 179
Cdd:TIGR00895 170 WRSLFYV 176
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 42-272 6.14e-06

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 48.51  E-value: 6.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   42 ALPSMAQEMQVPASIAVwFANGYLLAAAMTLAIFAALAARLGYRP-VFLAGLTTFTLTSLGCAlANKPEVLIGMRVLQGI 120
Cdd:pfam06609  66 ALPNILQDIGQSENQGL-FSTLWTMGQAVSILMMGRLTDRFGRRPfVIATHIIGLVGAIVGCT-ANKFNTLLAAMTLLGV 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  121 GGAatlsiaPAILRSVFPGRLLGRILGFHALLIAS-----SSAIGPVLGGTILHTLSWQWLFAINFL------------- 182
Cdd:pfam06609 144 AAG------PAGASPLFIGELMSNKTKFLGLLIVSaptiaMNGAGPYFGQRLAIQGNWRWIFYIYIImsaiavlliiiwy 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  183 -PGTLALLLAVRALPRDAIrmqAPFDTVGAIL-----SALLLG-STIMAANSLQNA-------TSQFGSLCWMALAALSG 248
Cdd:pfam06609 218 hPPSFAQLHGKKARKRDEL---AKLDWIGIFLviagtSLFLLGvSWGGKPNNPWNSakiigliSSGAGSLVIFALYEVFG 294

                         250       260
                  ....*....|....*....|....
gi 740647302  249 mafiwqirRTGHPLLPPSMFKNER 272
Cdd:pfam06609 295 --------KPEQPIIPPALFKDTR 310
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
5-179 1.30e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.18  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   5 SSHPGDEGLPGPARARVMAAIMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGY 84
Cdd:COG2807    3 TTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  85 RPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRlLGRILGFHALLIASSSAIGPVLG 164
Cdd:COG2807   83 ERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLT 161

                        170
                 ....*....|....*
gi 740647302 165 GTILHTLSWQWLFAI 179
Cdd:COG2807  162 VPLAAALGWRGALAV 176
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 20-179 2.28e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.45  E-value: 2.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  20 RVMAAIMTTTLMGVFdGTMINIALPSMAQE-MQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLT 98
Cdd:cd06173  209 LLRLLLLALALFALL-GGALTVLLPLLAKEvLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  99 SLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFA 178
Cdd:cd06173  288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFL 367


                 .
gi 740647302 179 I 179
Cdd:cd06173  368 L 368
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 47-179 4.63e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 45.61  E-value: 4.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  47 AQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIGGAATL 126
Cdd:cd17370  226 AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQE 305

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 740647302 127 SIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAI 179
Cdd:cd17370  306 SIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLF 358
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 21-179 5.97e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 44.95  E-value: 5.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  21 VMAAIMTTTLMGVFDGTMINIALPSMAQEMQVPASiAVWFANGYLLAAAMTLAIFAA-----LAARLGYRPVFLAGLTTF 95
Cdd:cd17391  202 LLISLFVTTFIIQLANQSIEPILTLYIRQLMGDAS-NLAFISGLVFSATGVSSLLSAprlgkLGDRIGHHRILLGALLAS 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  96 TLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQW 175
Cdd:cd17391  281 ALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRA 360


                 ....
gi 740647302 176 LFAI 179
Cdd:cd17391  361 VFVV 364
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
46-179 6.45e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 44.86  E-value: 6.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  46 MAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLG--YRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIGGA 123
Cdd:COG2271  207 LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLG 286

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 740647302 124 ATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAI 179
Cdd:COG2271  287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLL 342
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 35-184 7.93e-05

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 44.64  E-value: 7.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   35 DGTMINIALPSMAQEMQVPASIAVW----FANGYLLAAAMTLAIFAALAARLGYrPVFLAGLTTFTLTSlgcALANKPEV 110
Cdd:TIGR00893   9 DRANLSFAAPMLQEDLGLSAAQYGYvfsaFSWGYVVGQFPGGWLLDRFGARKTL-AVFIVIWGVFTGLQ---AFAGAYVS 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 740647302  111 LIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSWQWLFAINFLPG 184
Cdd:TIGR00893  85 LYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLG 158
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 30-183 1.10e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.22  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  30 LMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANKPE 109
Cdd:cd17371    9 ALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYW 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 110 VLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFhallIASSSAIGpVLGGTILHTL---------SWQWLFAIN 180
Cdd:cd17371   89 QLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGY----VQSGWAVG-WLLATLLAALlfpllppeiAWRVLFLLG 163


                 ...
gi 740647302 181 FLP 183
Cdd:cd17371  164 ALP 166
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
206-382 1.28e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.12  E-value: 1.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 206 FDTVGAILSALLLGSTIMAANSLQNATSQFGSLCWMALAALSGMAFIWQIRRTGHPLLPP--------SMFKNERFTLAA 277
Cdd:COG2211  155 FAGLGGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKvslkeslkALLKNRPFLLLL 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 278 FTSMVAFVSQGITFIALPFLFQSEYGYSPVVSALLFTPWPLGIVLIAPHAGRWADTISAPAISTLGLVIFVVGLILLATL 357
Cdd:COG2211  235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFL 314

                        170       180
                 ....*....|....*....|....*
gi 740647302 358 PArPSMWDICLRSLVCGIGFGCFQS 382
Cdd:COG2211  315 GP-GNLWLLLVLAALAGIGLGAILV 338
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
20-168 3.35e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 3.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  20 RVMAAIMTTTLMGVFdgTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTS 99
Cdd:COG2211  231 LLLLLAYLLFFLALA--LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGL 308

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 740647302 100 LGCALANK--PEVLIGMRVLQGIGGAATLSIAPAILRSVFP-------GRLLGRILGFHALLIASSSAIGPVLGGTIL 168
Cdd:COG2211  309 LLLFFLGPgnLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLL 386
Sugar_tr pfam00083
Sugar (and other) transporter;
59-184 3.78e-04

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 42.64  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302   59 WFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTFTLTSLGCALANK---PEVLIGMRVLQGIGGAATLSIAPAILRS 135
Cdd:pfam00083  50 LIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGkwsVYQLIVGRVLVGIGVGGASVLAPMYISE 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 740647302  136 VFPGRLLGRILGFHALLIASSSAIGPVLG---GTILHTLSWQWLFAINFLPG 184
Cdd:pfam00083 130 IAPKKLRGALGSLYQLAITFGILLAYIFGlglNKTSNSDGWRIPLGLQLVPA 181
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 24-219 1.15e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 41.14  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  24 AIMTTTLMGV--FDGTMIniaLPSMAQEMQVPASIAVWFAN----GYLLAAAMtlaiFAALAARLGYRPVFLAGLTTFTL 97
Cdd:cd06180    4 ALALAVAMGIgrFAYTPL---LPLMLAELGLSYAQAGWIATanyaGYLVGALL----ASFLRRRGRARRLIRGGLLLTVL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  98 TSLGCALANKPEVLIGMRVLQGIGGAATL----SIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILHTLSW 173
Cdd:cd06180   77 LLAAMALTSGFAALLALRFLAGAASAFVFvfgsNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAG 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 740647302 174 QWLFAINFLPGTLALLLAVRALPRDAIRMQAPFDTVGAILSALLLG 219
Cdd:cd06180  157 WLALALLSAVLLLLSFLLLRRGPSAPTEASAAESAPGLNRPLWRLA 202
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 75-180 1.32e-03

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 40.66  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  75 FAALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIGgaATLSIAPAILRSVFPGRLLGRILGFHALLIA 154
Cdd:cd17472   52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG--AISSVVMALLADLTREENRTKAMALIGASIG 129

                         90       100
                 ....*....|....*....|....*.
gi 740647302 155 SSSAIGPVLGGTILHTLSWQWLFAIN 180
Cdd:cd17472  130 IAFAISMVLGPLLAAHLGVSGLFLIT 155
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
16-179 2.00e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.22  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  16 PARARVMAAIMTTTLMGVFDGTMINIALPSMAQEMQVPASIAVWFANGYLLAAAMTLAIFAALAARLGYRPVFLAGLTTF 95
Cdd:COG0738    4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  96 TLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFHAlLIASSSAIGPVLGGTILH---TLS 172
Cdd:COG0738   84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHA-FFSLGALLGPLLGGLLILlglSLS 162


                 ....*..
gi 740647302 173 WQWLFAI 179
Cdd:COG0738  163 WHLPYLI 169
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 65-184 3.60e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 39.48  E-value: 3.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  65 LLAAAMTLAIFA-ALAARLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLG 143
Cdd:cd17315   43 LLLGAAIGSLFGgPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRG 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 740647302 144 RILGFHALLIA----SSSAIGPVLGGTILHtlSWQWLFAINFLPG 184
Cdd:cd17315  123 ALGTLNQLMITfgilLAYLLGLALSLSPPG--WWRLMFALAAVPA 165
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 43-182 7.51e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.36  E-value: 7.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  43 LPSMAQEMQVPASIAVWFAnGYLLAAAMTLAIFAALAA-----RLGYRPVFLAGLTTFTLTSLGCALANKPEVLIGMRVL 117
Cdd:cd17329   19 WPFMAIYLHQQLGLSASIV-GLVLALSAVAGIVASLIGgrladRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVL 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 740647302 118 QGIGGAATLSIAPAILRSVFPGRLLGRILGFHALLIASSSAIGPVLGGTILhTLSWQWLFAINFL 182
Cdd:cd17329   98 TGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAV 161
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 30-183 7.89e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 38.53  E-value: 7.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302  30 LMGVFDGTMINIALPSMAQEMQV----------PASIAVWFanGYLLAAAMtlaifaalAARLGYRPVFLAGLTTFTLTS 99
Cdd:PRK03893  30 LLDGFDFVLITLVLTEVQGEFGLttvqaaslisAAFISRWF--GGLLLGAM--------GDRYGRRLAMVISIVLFSVGT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 740647302 100 LGCALANKPEVLIGMRVLQGIGGAATLSIAPAILRSVFPGRLLGRILGFhallIASSSAIGPVLGGT----ILHTLSWQW 175
Cdd:PRK03893 100 LACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGF----LISGFSIGAVVAAQvyslVVPVWGWRA 175


                 ....*...
gi 740647302 176 LFAINFLP 183
Cdd:PRK03893 176 LFFIGILP 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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