MULTISPECIES: MFS transporter [Staphylococcus]
Protein Classification
MDR family MFS transporter( domain architecture ID 13023665)
MDR (multi-drug resistance) family major facilitator superfamily (MFS) transporter confers resistance to specific drugs/toxins through their active efflux from the cell
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||
| MFS_MdtH_MDR_like | cd17329 | Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
7-369 | 1.09e-93 | ||||||
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. : Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 286.05 E-value: 1.09e-93
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| Name | Accession | Description | Interval | E-value | ||||||
| MFS_MdtH_MDR_like | cd17329 | Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
7-369 | 1.09e-93 | ||||||
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 286.05 E-value: 1.09e-93
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| AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-343 | 2.76e-30 | ||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 119.31 E-value: 2.76e-30
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| MFS_1 | pfam07690 | Major Facilitator Superfamily; |
10-348 | 1.85e-27 | ||||||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.36 E-value: 1.85e-27
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| efflux_EmrB | TIGR00711 | drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
41-195 | 8.66e-05 | ||||||
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other] Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 44.68 E-value: 8.66e-05
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| PRK08633 | PRK08633 | 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
14-178 | 1.62e-04 | ||||||
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 44.14 E-value: 1.62e-04
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| Name | Accession | Description | Interval | E-value | ||||||
| MFS_MdtH_MDR_like | cd17329 | Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
7-369 | 1.09e-93 | ||||||
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 286.05 E-value: 1.09e-93
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| MFS_MdtG_SLC18_like | cd17325 | bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
10-369 | 5.76e-33 | ||||||
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 127.31 E-value: 5.76e-33
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| AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-343 | 2.76e-30 | ||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 119.31 E-value: 2.76e-30
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| MFS_1 | pfam07690 | Major Facilitator Superfamily; |
10-348 | 1.85e-27 | ||||||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 111.36 E-value: 1.85e-27
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| UhpC | COG2271 | Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-369 | 1.44e-20 | ||||||
Sugar phosphate permease [Carbohydrate transport and metabolism]; Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 92.24 E-value: 1.44e-20
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| FucP | COG0738 | Fucose permease [Carbohydrate transport and metabolism]; |
10-369 | 1.53e-20 | ||||||
Fucose permease [Carbohydrate transport and metabolism]; Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 92.22 E-value: 1.53e-20
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| MFS_YfmO_like | cd17474 | Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
32-369 | 2.66e-19 | ||||||
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 88.40 E-value: 2.66e-19
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| MFS_YfcJ_like | cd17489 | Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
35-365 | 1.16e-18 | ||||||
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 86.49 E-value: 1.16e-18
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| MFS_SLC46_TetA_like | cd17330 | Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
36-369 | 4.51e-18 | ||||||
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 84.55 E-value: 4.51e-18
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| MFS | cd06174 | Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
30-369 | 1.24e-16 | ||||||
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated. Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.93 E-value: 1.24e-16
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| MFS_MefA_like | cd06173 | Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
8-367 | 1.36e-14 | ||||||
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 74.57 E-value: 1.36e-14
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| NarK | COG2223 | Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
7-369 | 3.69e-14 | ||||||
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 73.38 E-value: 3.69e-14
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| MFS_MdtG_SLC18_like | cd17325 | bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
4-176 | 5.40e-14 | ||||||
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.61 E-value: 5.40e-14
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| AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
5-144 | 1.30e-13 | ||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.54 E-value: 1.30e-13
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| MFS_FucP_MFSD4_like | cd17333 | Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
23-359 | 7.56e-13 | ||||||
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 69.27 E-value: 7.56e-13
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| MFS_NepI_like | cd17324 | Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
34-369 | 9.06e-13 | ||||||
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 69.12 E-value: 9.06e-13
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| UhpC | COG2271 | Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-177 | 1.95e-11 | ||||||
Sugar phosphate permease [Carbohydrate transport and metabolism]; Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.89 E-value: 1.95e-11
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| MFS_NepI_like | cd17324 | Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
5-176 | 1.62e-10 | ||||||
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 62.18 E-value: 1.62e-10
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| MelB | COG2211 | Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
4-176 | 1.74e-10 | ||||||
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 62.23 E-value: 1.74e-10
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| MelB | COG2211 | Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
8-360 | 2.57e-10 | ||||||
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.84 E-value: 2.57e-10
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| MFS_MefA_like | cd06173 | Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
7-178 | 4.03e-10 | ||||||
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 61.09 E-value: 4.03e-10
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| AraJ | COG2814 | Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
197-369 | 5.68e-10 | ||||||
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 60.37 E-value: 5.68e-10
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| MFS_DtpA_like | cd17346 | Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
59-354 | 8.09e-09 | ||||||
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 56.81 E-value: 8.09e-09
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| ProP | COG0477 | MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
32-177 | 1.13e-08 | ||||||
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]; Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 55.97 E-value: 1.13e-08
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| MFS_MMR_MDR_like | cd17321 | Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
32-358 | 1.33e-08 | ||||||
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.03 E-value: 1.33e-08
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| MFS_ExuT_GudP_like | cd17319 | Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
31-358 | 1.84e-08 | ||||||
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 55.65 E-value: 1.84e-08
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| MFS_arabinose_efflux_permease_like | cd17473 | Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
41-355 | 2.45e-08 | ||||||
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 55.27 E-value: 2.45e-08
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| MFS_MFSD6 | cd17335 | Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
20-364 | 2.53e-08 | ||||||
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 55.28 E-value: 2.53e-08
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| MFS_MJ1317_like | cd17370 | MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
26-365 | 3.70e-08 | ||||||
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 54.86 E-value: 3.70e-08
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| CynX | COG2807 | Cyanate permease [Inorganic ion transport and metabolism]; |
4-359 | 5.19e-08 | ||||||
Cyanate permease [Inorganic ion transport and metabolism]; Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 54.49 E-value: 5.19e-08
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| MFS_1 | pfam07690 | Major Facilitator Superfamily; |
209-369 | 6.08e-08 | ||||||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.96 E-value: 6.08e-08
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| MFS_SV2_like | cd17316 | Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
8-176 | 1.23e-07 | ||||||
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.99 E-value: 1.23e-07
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| MFS_MMR_MDR_like | cd17321 | Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
5-152 | 2.69e-07 | ||||||
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 52.18 E-value: 2.69e-07
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| MFS_SV2_like | cd17316 | Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
36-369 | 2.76e-07 | ||||||
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.22 E-value: 2.76e-07
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| MFS_MosC_like | cd17393 | Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
4-175 | 4.72e-07 | ||||||
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 51.49 E-value: 4.72e-07
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| MFS | cd06174 | Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
5-176 | 5.08e-07 | ||||||
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated. Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 51.27 E-value: 5.08e-07
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| MFS_Amf1_MDR_like | cd17476 | Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
59-359 | 6.40e-07 | ||||||
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 51.11 E-value: 6.40e-07
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| CynX | COG2807 | Cyanate permease [Inorganic ion transport and metabolism]; |
7-176 | 6.68e-07 | ||||||
Cyanate permease [Inorganic ion transport and metabolism]; Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.03 E-value: 6.68e-07
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| MFS_FsR | cd17478 | Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
10-369 | 9.23e-07 | ||||||
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.63 E-value: 9.23e-07
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| MFS_LmrB_MDR_like | cd17503 | Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
10-148 | 1.28e-06 | ||||||
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.88 E-value: 1.28e-06
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| MFS_MT3072_like | cd17475 | Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
12-176 | 2.35e-06 | ||||||
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.16 E-value: 2.35e-06
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| MFS_1 | pfam07690 | Major Facilitator Superfamily; |
5-146 | 3.41e-06 | ||||||
Major Facilitator Superfamily; Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 3.41e-06
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| MFS_PcaK_like | cd17365 | 4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
43-153 | 6.79e-06 | ||||||
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 47.58 E-value: 6.79e-06
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| MFS_YajR_like | cd17472 | Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
26-369 | 7.00e-06 | ||||||
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 47.60 E-value: 7.00e-06
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| ProP | COG0477 | MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
275-365 | 1.75e-05 | ||||||
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only]; Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 46.34 E-value: 1.75e-05
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| MFS_NepI_like | cd17324 | Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
231-367 | 2.21e-05 | ||||||
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.00 E-value: 2.21e-05
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| MFS_SLC17 | cd17318 | Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
42-154 | 3.31e-05 | ||||||
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 45.69 E-value: 3.31e-05
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| MFS_Azr1_MDR_like | cd17502 | Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
30-176 | 6.51e-05 | ||||||
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 44.48 E-value: 6.51e-05
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| MFS_LmrB_MDR_like | cd17503 | Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
275-368 | 7.62e-05 | ||||||
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.49 E-value: 7.62e-05
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| efflux_EmrB | TIGR00711 | drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
41-195 | 8.66e-05 | ||||||
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other] Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 44.68 E-value: 8.66e-05
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| 2A0115 | TIGR00895 | benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
2-155 | 9.38e-05 | ||||||
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids] Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 44.27 E-value: 9.38e-05
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| MFS | cd06174 | Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
210-369 | 1.05e-04 | ||||||
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated. Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 43.95 E-value: 1.05e-04
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| MFS_1_like | pfam12832 | MFS_1 like family; This family contains proteins related to the MFS superfamily. |
44-359 | 1.09e-04 | ||||||
MFS_1 like family; This family contains proteins related to the MFS superfamily. Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 43.77 E-value: 1.09e-04
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| PRK08633 | PRK08633 | 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
14-178 | 1.62e-04 | ||||||
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 44.14 E-value: 1.62e-04
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| MFS_arabinose_efflux_permease_like | cd17473 | Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
4-119 | 1.84e-04 | ||||||
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 1.84e-04
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| MFS_OFA_like | cd17353 | Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
5-176 | 2.07e-04 | ||||||
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.98 E-value: 2.07e-04
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| MFS_PcaK_like | cd17365 | 4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
39-176 | 2.17e-04 | ||||||
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 42.96 E-value: 2.17e-04
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| MFS_MosC_like | cd17393 | Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
33-150 | 2.28e-04 | ||||||
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 43.02 E-value: 2.28e-04
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| MFS_ExuT_GudP_like | cd17319 | Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
7-177 | 4.85e-04 | ||||||
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 4.85e-04
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| MFS_YcaD_like | cd17477 | YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
10-369 | 5.27e-04 | ||||||
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.78 E-value: 5.27e-04
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| MFS_YxlH_like | cd17490 | Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
34-367 | 5.73e-04 | ||||||
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.82 E-value: 5.73e-04
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| MFS_SLC17A9_like | cd17380 | Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
26-150 | 9.99e-04 | ||||||
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 41.00 E-value: 9.99e-04
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| MFS_YcxA_like | cd17355 | MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
8-366 | 1.06e-03 | ||||||
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.10 E-value: 1.06e-03
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| MFS_MMR_MDR_like | cd17504 | Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
41-176 | 1.70e-03 | ||||||
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 40.25 E-value: 1.70e-03
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| MFS_Set | cd17471 | Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
10-373 | 1.70e-03 | ||||||
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 1.70e-03
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| MFS_GLUT6_8_Class3_like | cd17358 | Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
49-160 | 1.82e-03 | ||||||
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 40.25 E-value: 1.82e-03
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| NarK | COG2223 | Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
201-369 | 2.21e-03 | ||||||
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 39.86 E-value: 2.21e-03
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| MFS_MucK | cd17371 | Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
31-153 | 2.89e-03 | ||||||
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 39.59 E-value: 2.89e-03
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| MFS_MCT_like | cd17314 | Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
18-357 | 3.82e-03 | ||||||
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 39.32 E-value: 3.82e-03
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| 2A0104 | TIGR00881 | phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
32-364 | 3.88e-03 | ||||||
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids] Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.28 E-value: 3.88e-03
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| PRK05122 | PRK05122 | major facilitator superfamily transporter; Provisional |
10-111 | 4.90e-03 | ||||||
major facilitator superfamily transporter; Provisional Pssm-ID: 235348 [Multi-domain] Cd Length: 399 Bit Score: 38.71 E-value: 4.90e-03
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| MFS_Azr1_MDR_like | cd17502 | Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
272-364 | 6.61e-03 | ||||||
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 38.31 E-value: 6.61e-03
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| FucP | COG0738 | Fucose permease [Carbohydrate transport and metabolism]; |
199-355 | 7.22e-03 | ||||||
Fucose permease [Carbohydrate transport and metabolism]; Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.30 E-value: 7.22e-03
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| MFS_NRT2_like | cd17341 | Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
23-175 | 7.67e-03 | ||||||
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.39 E-value: 7.67e-03
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| PRK10091 | PRK10091 | MFS transport protein AraJ; Provisional |
9-175 | 9.22e-03 | ||||||
MFS transport protein AraJ; Provisional Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 37.76 E-value: 9.22e-03
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