NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|738760823|ref|WP_036654092|]
View 

GntR family transcriptional regulator [Paenibacillus larvae]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-240 7.64e-93

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 272.51  E-value: 7.64e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   6 KSRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQSLIK 85
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823  86 FYSFSEEMKKLGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHELEKR 165
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738760823 166 SMYEIFRTDYQLSLTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGN-LPVEHSISIARGDRYYYATELS 240
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADgRPVEYSRSYYRGDRYRFVVELR 236
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-240 7.64e-93

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 272.51  E-value: 7.64e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   6 KSRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQSLIK 85
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823  86 FYSFSEEMKKLGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHELEKR 165
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738760823 166 SMYEIFRTDYQLSLTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGN-LPVEHSISIARGDRYYYATELS 240
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADgRPVEYSRSYYRGDRYRFVVELR 236
PRK11402 PRK11402
transcriptional regulator PhoB;
3-232 4.60e-49

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 161.16  E-value: 4.60e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   3 IDKKSRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQS 82
Cdd:PRK11402   2 TDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823  83 LIKFYSFSEEMKKLGKHPVTEVINFEIsPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHEL 162
Cdd:PRK11402  82 LLTVSGFTDFGVSQGKATKEKVIEQER-VSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYV 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738760823 163 EKRSMYEIFRTDYQLSLTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGN-LPVEHSISIARGDR 232
Cdd:PRK11402 161 EGSSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNdKPVHVSELFCRANR 231
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 96-233 3.26e-41

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 137.73  E-value: 3.26e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   96 LGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHELEKRSMYEIFRTDY 175
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEERY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 738760823  176 QLSLTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGN-LPVEHSISIARGDRY 233
Cdd:pfam07702  82 GLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDgRPVEYSRSYYRGDRY 140
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 96-233 1.38e-38

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 130.88  E-value: 1.38e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823    96 LGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHELEkRSMYEIFRTDY 175
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLS-GSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738760823   176 QLS---LTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAY-SGNLPVEHSISIARGDRY 233
Cdd:smart00866  81 GLKivrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYdDDGRPVEYSRSYYRGDRF 142
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 3-238 3.21e-34

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 122.97  E-value: 3.21e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823    3 IDKKSRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQS 82
Cdd:TIGR02325   1 IERTSGVALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   83 LIKFYSFSEEMKKLGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHEL 162
Cdd:TIGR02325  81 LSARTRFSQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823  163 EKRSMYEIFR----TDYQLSLTsaheRFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGN-LPVEHSISIARGDRYYYAT 237
Cdd:TIGR02325 161 ASGSITDALReqgvADYRRSST----RISARHADAKDCARLELPPGRPLLVVQALNHDGEgRPVQYSVSRFRADRVEFTM 236


                  .
gi 738760823  238 E 238
Cdd:TIGR02325 237 E 237
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 10-75 2.15e-29

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 104.84  E-value: 2.15e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738760823  10 PLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVS 75
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
6-240 7.64e-93

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 272.51  E-value: 7.64e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   6 KSRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQSLIK 85
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823  86 FYSFSEEMKKLGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHELEKR 165
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738760823 166 SMYEIFRTDYQLSLTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGN-LPVEHSISIARGDRYYYATELS 240
Cdd:COG2188  161 SLYELLEERYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADgRPVEYSRSYYRGDRYRFVVELR 236
PRK11402 PRK11402
transcriptional regulator PhoB;
3-232 4.60e-49

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 161.16  E-value: 4.60e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   3 IDKKSRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQS 82
Cdd:PRK11402   2 TDRYSHQLLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823  83 LIKFYSFSEEMKKLGKHPVTEVINFEIsPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHEL 162
Cdd:PRK11402  82 LLTVSGFTDFGVSQGKATKEKVIEQER-VSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYV 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738760823 163 EKRSMYEIFRTDYQLSLTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGN-LPVEHSISIARGDR 232
Cdd:PRK11402 161 EGSSTYQLFQERFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNdKPVHVSELFCRANR 231
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 96-233 3.26e-41

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 137.73  E-value: 3.26e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   96 LGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHELEKRSMYEIFRTDY 175
Cdd:pfam07702   2 QGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEERY 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 738760823  176 QLSLTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGN-LPVEHSISIARGDRY 233
Cdd:pfam07702  82 GLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDgRPVEYSRSYYRGDRY 140
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 96-233 1.38e-38

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 130.88  E-value: 1.38e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823    96 LGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHELEkRSMYEIFRTDY 175
Cdd:smart00866   2 QGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLS-GSLYEYLEERL 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738760823   176 QLS---LTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAY-SGNLPVEHSISIARGDRY 233
Cdd:smart00866  81 GLKivrSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYdDDGRPVEYSRSYYRGDRF 142
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 3-238 3.21e-34

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 122.97  E-value: 3.21e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823    3 IDKKSRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQS 82
Cdd:TIGR02325   1 IERTSGVALWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   83 LIKFYSFSEEMKKLGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHEL 162
Cdd:TIGR02325  81 LSARTRFSQNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPGIGQAYA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823  163 EKRSMYEIFR----TDYQLSLTsaheRFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGN-LPVEHSISIARGDRYYYAT 237
Cdd:TIGR02325 161 ASGSITDALReqgvADYRRSST----RISARHADAKDCARLELPPGRPLLVVQALNHDGEgRPVQYSVSRFRADRVEFTM 236


                  .
gi 738760823  238 E 238
Cdd:TIGR02325 237 E 237
trehalos_R_Bsub TIGR02404
trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR ...
 12-182 1.05e-31

trehalose operon repressor, B. subtilis-type; This family consists of repressors of the GntR family typically associated with trehalose utilization operons. Trehalose is imported as trehalose-6-phosphate and then hydrolyzed by alpha,alpha-phosphotrehalase to glucose and glucose-6-P. This family includes repressors mostly from Gram-positive lineages and does not include the TreR from E. coli. [Regulatory functions, DNA interactions]


Pssm-ID: 274116 [Multi-domain]  Cd Length: 233  Bit Score: 115.92  E-value: 1.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   12 YAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFV-SPQTYTQSLIKFYSFS 90
Cdd:TIGR02404   2 YEQIYQDLEQKITKGQYKEGDYLPSEHELMDQYGASRETVRKALNLLTERGYIQKIQGKGSIVlNRKQIEFPISGITSFK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   91 EEMKKLGKHPVTEVINFEI-SPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHELEKrSMYE 169
Cdd:TIGR02404  82 ELNETLGLDSKTEVVELDKeDPLPETLAQLTGLEEGSLIWRIKRVRVIDGEAVILDIDYLLKELVPGLTKEIAED-SIYQ 160

                         170
                  ....*....|...
gi 738760823  170 IFRTDYQLSLTSA 182
Cdd:TIGR02404 161 YLENELGLAISYA 173
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 10-233 2.34e-31

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 115.11  E-value: 2.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   10 PLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQSLIKFYSF 89
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   90 SEEMKKLGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPgltrhELEKRSMYE 169
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVP-----DYLKQDFTQ 155

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738760823  170 IFRTDYQLS---LTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGNLPVEHSISIARGDRY 233
Cdd:TIGR02018 156 TTPGAYLSQaapLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRY 222
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 10-75 2.15e-29

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 104.84  E-value: 2.15e-29
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738760823  10 PLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVS 75
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
PRK09764 PRK09764
GntR family transcriptional regulator;
7-164 3.99e-25

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 99.13  E-value: 3.99e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   7 SRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQSLIKF 86
Cdd:PRK09764   2 GHKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQL 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738760823  87 YSFSEEMKKLGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHELEK 164
Cdd:PRK09764  82 TSFDEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALFPDLTWQVMEN 159
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
1-77 7.50e-25

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 94.48  E-value: 7.50e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738760823   1 MIIDKKSRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQ 77
Cdd:COG1725    1 IRIDFDSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAED 77
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 3-77 1.18e-23

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 98.36  E-value: 1.18e-23
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738760823   3 IDKKSRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQ 77
Cdd:COG1167    5 LDRDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 11-74 2.24e-20

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 81.51  E-value: 2.24e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738760823   11 LYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFV 74
Cdd:pfam00392   1 LYEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
7-76 2.75e-20

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 85.76  E-value: 2.75e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   7 SRIPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSP 76
Cdd:COG2186    4 RRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVRE 73
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
15-74 1.43e-18

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 76.46  E-value: 1.43e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823    15 LYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFV 74
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK14999 PRK14999
histidine utilization repressor; Provisional
 10-233 7.14e-18

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 79.59  E-value: 7.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823  10 PLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQSLIKFYSF 89
Cdd:PRK14999  12 PFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEVRSI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823  90 SEEMKKLGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLPVNIFPGLTRHELEKRSMYe 169
Cdd:PRK14999  92 AEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLTQDYRQTTPH- 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738760823 170 ifrtDYqLS----LTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIERTAYSGNLPVEHSISIARGDRY 233
Cdd:PRK14999 171 ----AY-LSriapLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRY 233
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 7-231 3.06e-17

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 77.89  E-value: 3.06e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   7 SRIP-LYAQLYDHILDKIKSgEWREHEK----LPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQ 81
Cdd:PRK10079   4 SRHPtSYPTRYQEIAAKLEQ-ELRQHYRcgdyLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRPYDY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823  82 SLIKFYSFSEEMKKLGKHPVTEVINFEISPCSSKIAKKLELEVETPVYKIKRLRSAEDEPIMVETTYLP-VNIFPGLTRh 160
Cdd:PRK10079  83 PLNAQARFSQNLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFAdLTWWPTLQR- 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738760823 161 eLEKRSMYEIFRTDYQLSLTSAHERFKAVIIKEKEAPFLDGQPGNPAMKIeRTAYSGN---LPVEHSISIARGD 231
Cdd:PRK10079 162 -FDSGSLHDFLREQLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCV-RTLNHRDgesSPAEYSVSLTRAD 233
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
7-76 1.31e-14

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 70.34  E-value: 1.31e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738760823   7 SRIPLYAQLYDHILDKIKSGEWREHEKLpSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSP 76
Cdd:COG1802    8 RRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
PRK11523 PRK11523
transcriptional regulator ExuR;
11-74 7.54e-09

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 54.47  E-value: 7.54e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738760823  11 LYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFV 74
Cdd:PRK11523   9 LYQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
PRK10225 PRK10225
Uxu operon transcriptional regulator;
12-74 4.33e-08

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 52.33  E-value: 4.33e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 738760823  12 YAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFV 74
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYV 73
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 34-78 5.02e-08

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 52.08  E-value: 5.02e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 738760823  34 LPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQT 78
Cdd:PRK09990  31 LPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLN 75
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 15-69 4.84e-07

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 49.25  E-value: 4.84e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 738760823  15 LYDHILDK----IKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHG 69
Cdd:PRK03837  14 LSEEVEERleqmIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVQISHG 72
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 9-82 1.83e-05

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 44.76  E-value: 1.83e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738760823   9 IPLYAQLYDHILDKIKSGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYTQS 82
Cdd:PRK10421   1 RRLSDEVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFIRWRHETWS 74
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
13-83 7.16e-05

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 42.70  E-value: 7.16e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738760823  13 AQLYDHILDkiksGEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQTYtQSL 83
Cdd:PRK09464  17 QQLEFLILE----GTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLW-QSF 82
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 18-71 2.89e-04

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 40.67  E-value: 2.89e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 738760823  18 HILDKIKSgEWREHEKLPSEREICETYGISRTTVRQTMIELENEGYIYKEHGRG 71
Cdd:COG1974   10 EILDFIKE-YIRERGYPPSQREIAEALGLSSSAVHRHLKALEKKGYLRRDPGKS 62
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
39-73 5.91e-04

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 37.95  E-value: 5.91e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 738760823    39 EICETYGISRTTVRQTMIELENEGYIYKEHGRGSF 73
Cdd:smart00346  25 ELAERLGLSKSTAHRLLNTLQELGYVEQDGQNGRY 59
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
39-77 3.59e-03

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 34.93  E-value: 3.59e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 738760823   39 EICETYGISRTTVRQTMIELENEGYIYKEHGRGSFVSPQ 77
Cdd:pfam08220  19 ELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNSST 57
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 17-69 7.45e-03

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 36.65  E-value: 7.45e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 738760823  17 DHILDKIksgewREHEKLPSErEICETYGISRTTVRQTMIELENEGYIYKEHG 69
Cdd:COG1349    8 QKILELL-----RERGRVSVE-ELAERLGVSEETIRRDLAELEEQGLLRRVHG 54
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
39-69 9.22e-03

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 33.35  E-value: 9.22e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 738760823    39 EICETYGISRTTVRQTMIELENEGYIYKEHG 69
Cdd:smart00420  19 ELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH