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Conserved domains on  [gi|738459163|ref|WP_036410189|]
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type VII secretion AAA-ATPase EccA [Mycobacterium gastri]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T7SS_EccA super family cl33216
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 57-609 0e+00

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


The actual alignment was detected with superfamily member TIGR03922:

Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 765.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163   57 FTALTRIAGDQCDAWTGLAAAGEQSVGVLEAVSRTAATAGVLQRHVELEPNALGFHYDTGLYLRFRATGPDDFHLAYAAA 136
Cdd:TIGR03922   1 FTAATNLDPSMCDAWLGRIAAGDVDLAVLAAAWRTIATFGWLQRELGLAEGQLGAEIDTGLYLQFRVTSPDDFQLAYAVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  137 LATAGDYAKAHDVVAGITGRRPGWREARWIMVVVNYRAARWSDVVKLLTPIVNDPALDQTFAHAAKITLGTALARLGMFA 216
Cdd:TIGR03922  81 LAEAGEYAEADRLLAGVEARRPGWVDARWVRVVIYYRTQRWPDVLNQLPPGVGWPSLDDKAAHAAAAAHGVALARLGMFA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  217 PALSYLEE----PEGPVPVAALDGALAKALVLRAHVDEESAAEVLQDLYAAHPENEQVEQALSDTSFGIVTTTAARIEAR 292
Cdd:TIGR03922 161 EALRRLEEaiegPRGPAAAPVADGAYAKAMVLRALGEEDEAQELLQDLYANHPENTQVEEALDDPSYRLVTTTAETIEAR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  293 TDPWDPETEPSADDFIDPAAHERKAALLHEAERQLAEFIGLDEVKNQVSRLKSSVAMELVRKQRGLTVAQRTHHLIFAGP 372
Cdd:TIGR03922 241 TDPWDPSSAPSRAEFVDPAAAERKAKLLAEAEAELAEQIGLERVKRQVAALKSSTAMALARAERGLPVAQTSNHMLFAGP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  373 PGTGKTTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEAYALVAT--GAKNDFGL 450
Cdd:TIGR03922 321 PGTGKTTIARVVAKIYCGLGVLRKPLVREVSRADLIGQYIGESEAKTNEIIDSALGGVLFLDEAYTLVETgyGQKDPFGL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  451 VAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTRSIEFPSYTSHELVEIAHKMAEQRDSVFERSALDHLE 530
Cdd:TIGR03922 401 EAIDTLLARMENDRDRLVVIGAGYRKDLDKFLEVNEGLRSRFTRVIEFPSYSPDELVEIARRMATERDSVLDDAAADALL 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738459163  531 ALFATLAASSTPDSNGINRRSLDIAGNGRFVRNIVERAEEEREFRLDHSEHagTGEFSDDELMTITAADVNRSVEPLLR 609
Cdd:TIGR03922 481 EAATTLAQDTTPDANGDLRRGLDIAGNGRFVRNVVERAEEERDFRLDHSDR--LDAVTVDDLMEITADDVARAVASLLR 557
 
Name Accession Description Interval E-value
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 57-609 0e+00

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 765.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163   57 FTALTRIAGDQCDAWTGLAAAGEQSVGVLEAVSRTAATAGVLQRHVELEPNALGFHYDTGLYLRFRATGPDDFHLAYAAA 136
Cdd:TIGR03922   1 FTAATNLDPSMCDAWLGRIAAGDVDLAVLAAAWRTIATFGWLQRELGLAEGQLGAEIDTGLYLQFRVTSPDDFQLAYAVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  137 LATAGDYAKAHDVVAGITGRRPGWREARWIMVVVNYRAARWSDVVKLLTPIVNDPALDQTFAHAAKITLGTALARLGMFA 216
Cdd:TIGR03922  81 LAEAGEYAEADRLLAGVEARRPGWVDARWVRVVIYYRTQRWPDVLNQLPPGVGWPSLDDKAAHAAAAAHGVALARLGMFA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  217 PALSYLEE----PEGPVPVAALDGALAKALVLRAHVDEESAAEVLQDLYAAHPENEQVEQALSDTSFGIVTTTAARIEAR 292
Cdd:TIGR03922 161 EALRRLEEaiegPRGPAAAPVADGAYAKAMVLRALGEEDEAQELLQDLYANHPENTQVEEALDDPSYRLVTTTAETIEAR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  293 TDPWDPETEPSADDFIDPAAHERKAALLHEAERQLAEFIGLDEVKNQVSRLKSSVAMELVRKQRGLTVAQRTHHLIFAGP 372
Cdd:TIGR03922 241 TDPWDPSSAPSRAEFVDPAAAERKAKLLAEAEAELAEQIGLERVKRQVAALKSSTAMALARAERGLPVAQTSNHMLFAGP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  373 PGTGKTTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEAYALVAT--GAKNDFGL 450
Cdd:TIGR03922 321 PGTGKTTIARVVAKIYCGLGVLRKPLVREVSRADLIGQYIGESEAKTNEIIDSALGGVLFLDEAYTLVETgyGQKDPFGL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  451 VAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTRSIEFPSYTSHELVEIAHKMAEQRDSVFERSALDHLE 530
Cdd:TIGR03922 401 EAIDTLLARMENDRDRLVVIGAGYRKDLDKFLEVNEGLRSRFTRVIEFPSYSPDELVEIARRMATERDSVLDDAAADALL 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738459163  531 ALFATLAASSTPDSNGINRRSLDIAGNGRFVRNIVERAEEEREFRLDHSEHagTGEFSDDELMTITAADVNRSVEPLLR 609
Cdd:TIGR03922 481 EAATTLAQDTTPDANGDLRRGLDIAGNGRFVRNVVERAEEERDFRLDHSDR--LDAVTVDDLMEITADDVARAVASLLR 557
cbbX CHL00181
CbbX; Provisional
 329-603 7.87e-49

CbbX; Provisional


Pssm-ID: 177083 [Multi-domain]  Cd Length: 287  Bit Score: 171.82  E-value: 7.87e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 329 EFIGLDEVKNQVSRLKSSVAMELVRKQRGLTVAQRTHHLIFAGPPGTGKTTIARVVAKIYCGLGLLKRENIREVHRADLI 408
Cdd:CHL00181  24 ELVGLAPVKTRIREIAALLLIDRLRKNLGLTSSNPGLHMSFTGSPGTGKTTVALKMADILYKLGYIKKGHLLTVTRDDLV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 409 GQHIGETEAKTNAIIDSALDGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGL 488
Cdd:CHL00181 104 GQYIGHTAPKTKEVLKKAMGGVLFIDEAYYLYKPDNERDYGSEAIEILLQVMENQRDDLVVIFAGYKDRMDKFYESNPGL 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 489 RSRFTRSIEFPSYTSHELVEIAHKMAEQRDSVF----ERSALDHLEalfatlaasstpdsngiNRRSLDIAGNGRFVRNI 564
Cdd:CHL00181 184 SSRIANHVDFPDYTPEELLQIAKIMLEEQQYQLtpeaEKALLDYIK-----------------KRMEQPLFANARSVRNA 246

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 738459163 565 VERAEEEREFRLDHSehaGTGEFSDDELMTITAADVNRS 603
Cdd:CHL00181 247 LDRARMRQANRIFES---GGRVLTKADLVTIEAEDILKS 282
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 173-518 3.70e-43

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 159.69  E-value: 3.70e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 173 RAARWSDVVKLLTPIVNDPALDQTFAHAAKITLGTALARLGMFAPALSYLEEPEGPVPVAALDGALAKALVLRAHVDEES 252
Cdd:COG0464    4 LLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 253 AAEVLQDLYAAHPENEQVEQALSDTSFGIVTTTAARIEARTDPWDPETEPSADDFIDPAAHERKAALLHEAErqLAEFIG 332
Cdd:COG0464   84 ALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAI--LDDLGG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 333 LDEVKNQVSRLKSSVAMEL-VRKQRGLTvaqRTHHLIFAGPPGTGKTTIARVVAKIycgLGLlkreNIREVHRADLIGQH 411
Cdd:COG0464  162 LEEVKEELRELVALPLKRPeLREEYGLP---PPRGLLLYGPPGTGKTLLARALAGE---LGL----PLIEVDLSDLVSKY 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 412 IGETEAKTNAIIDSALD---GVLFLDEAYALVA--TGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRadldkFLDTNE 486
Cdd:COG0464  232 VGETEKNLREVFDKARGlapCVLFIDEADALAGkrGEVGDGVGRRVVNTLLTEMEELRSDVVVIAATNR-----PDLLDP 306

                        330       340       350
                 ....*....|....*....|....*....|..
gi 738459163 487 GLRSRFTRSIEFPSYTSHELVEIAHKMAEQRD 518
Cdd:COG0464  307 ALLRRFDEIIFFPLPDAEERLEIFRIHLRKRP 338
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 367-499 7.68e-22

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 91.50  E-value: 7.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  367 LIFAGPPGTGKTTIARVVAKiYCGLgllkreNIREVHRADLIGQHIGETEAKTNAIIDSA---LDGVLFLDEAYALVATG 443
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAK-ELGA------PFIEISGSELVSKYVGESEKRLRELFEAAkklAPCVIFIDEIDALAGSR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738459163  444 AKN--DFGLVAIDTLLARME---NDRDRLVVIIAGYRADLdkfLDtnEGLRSRFTRSIEFP 499
Cdd:pfam00004  74 GSGgdSESRRVVNQLLTELDgftSSNSKVIVIAATNRPDK---LD--PALLGRFDRIIEFP 129
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 347-500 1.19e-13

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 68.71  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 347 VAMELVRKQRGLTVAQRTH-HLIFAGPPGTGKTTIARVVAKIYcglgLLKRENIREVHRADLIGQHIGETEAKTNAIIDS 425
Cdd:cd00009    1 VGQEEAIEALREALELPPPkNLLLYGPPGTGKTTLARAIANEL----FRPGAPFLYLNASDLLEGLVVAELFGHFLVRLL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 426 ALD------GVLFLDEAYALvaTGAKNDFGLVAIDTLLARMEnDRDRLVVIIAGYRADLDKFLdtnEGLRSRFTRSIEFP 499
Cdd:cd00009   77 FELaekakpGVLFIDEIDSL--SRGAQNALLRVLETLNDLRI-DRENVRVIGATNRPLLGDLD---RALYDRLDIRIVIP 150


                 .
gi 738459163 500 S 500
Cdd:cd00009  151 L 151
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 365-499 3.70e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 52.76  E-value: 3.70e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163   365 HHLIFAGPPGTGKTTIARVVAKIY----CGLGLLKRENIREVHRADLIGQHIGETEAKT---------NAIIDSALDGVL 431
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELgppgGGVIYIDGEDILEEVLDQLLLIIVGGKKASGsgelrlrlaLALARKLKPDVL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738459163   432 FLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLdtnegLRSRFTRSIEFP 499
Cdd:smart00382  83 ILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPAL-----LRRRFDRRIVLL 145
 
Name Accession Description Interval E-value
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 57-609 0e+00

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 765.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163   57 FTALTRIAGDQCDAWTGLAAAGEQSVGVLEAVSRTAATAGVLQRHVELEPNALGFHYDTGLYLRFRATGPDDFHLAYAAA 136
Cdd:TIGR03922   1 FTAATNLDPSMCDAWLGRIAAGDVDLAVLAAAWRTIATFGWLQRELGLAEGQLGAEIDTGLYLQFRVTSPDDFQLAYAVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  137 LATAGDYAKAHDVVAGITGRRPGWREARWIMVVVNYRAARWSDVVKLLTPIVNDPALDQTFAHAAKITLGTALARLGMFA 216
Cdd:TIGR03922  81 LAEAGEYAEADRLLAGVEARRPGWVDARWVRVVIYYRTQRWPDVLNQLPPGVGWPSLDDKAAHAAAAAHGVALARLGMFA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  217 PALSYLEE----PEGPVPVAALDGALAKALVLRAHVDEESAAEVLQDLYAAHPENEQVEQALSDTSFGIVTTTAARIEAR 292
Cdd:TIGR03922 161 EALRRLEEaiegPRGPAAAPVADGAYAKAMVLRALGEEDEAQELLQDLYANHPENTQVEEALDDPSYRLVTTTAETIEAR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  293 TDPWDPETEPSADDFIDPAAHERKAALLHEAERQLAEFIGLDEVKNQVSRLKSSVAMELVRKQRGLTVAQRTHHLIFAGP 372
Cdd:TIGR03922 241 TDPWDPSSAPSRAEFVDPAAAERKAKLLAEAEAELAEQIGLERVKRQVAALKSSTAMALARAERGLPVAQTSNHMLFAGP 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  373 PGTGKTTIARVVAKIYCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDGVLFLDEAYALVAT--GAKNDFGL 450
Cdd:TIGR03922 321 PGTGKTTIARVVAKIYCGLGVLRKPLVREVSRADLIGQYIGESEAKTNEIIDSALGGVLFLDEAYTLVETgyGQKDPFGL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  451 VAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGLRSRFTRSIEFPSYTSHELVEIAHKMAEQRDSVFERSALDHLE 530
Cdd:TIGR03922 401 EAIDTLLARMENDRDRLVVIGAGYRKDLDKFLEVNEGLRSRFTRVIEFPSYSPDELVEIARRMATERDSVLDDAAADALL 480

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738459163  531 ALFATLAASSTPDSNGINRRSLDIAGNGRFVRNIVERAEEEREFRLDHSEHagTGEFSDDELMTITAADVNRSVEPLLR 609
Cdd:TIGR03922 481 EAATTLAQDTTPDANGDLRRGLDIAGNGRFVRNVVERAEEERDFRLDHSDR--LDAVTVDDLMEITADDVARAVASLLR 557
cbbX CHL00181
CbbX; Provisional
 329-603 7.87e-49

CbbX; Provisional


Pssm-ID: 177083 [Multi-domain]  Cd Length: 287  Bit Score: 171.82  E-value: 7.87e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 329 EFIGLDEVKNQVSRLKSSVAMELVRKQRGLTVAQRTHHLIFAGPPGTGKTTIARVVAKIYCGLGLLKRENIREVHRADLI 408
Cdd:CHL00181  24 ELVGLAPVKTRIREIAALLLIDRLRKNLGLTSSNPGLHMSFTGSPGTGKTTVALKMADILYKLGYIKKGHLLTVTRDDLV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 409 GQHIGETEAKTNAIIDSALDGVLFLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLDTNEGL 488
Cdd:CHL00181 104 GQYIGHTAPKTKEVLKKAMGGVLFIDEAYYLYKPDNERDYGSEAIEILLQVMENQRDDLVVIFAGYKDRMDKFYESNPGL 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 489 RSRFTRSIEFPSYTSHELVEIAHKMAEQRDSVF----ERSALDHLEalfatlaasstpdsngiNRRSLDIAGNGRFVRNI 564
Cdd:CHL00181 184 SSRIANHVDFPDYTPEELLQIAKIMLEEQQYQLtpeaEKALLDYIK-----------------KRMEQPLFANARSVRNA 246

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 738459163 565 VERAEEEREFRLDHSehaGTGEFSDDELMTITAADVNRS 603
Cdd:CHL00181 247 LDRARMRQANRIFES---GGRVLTKADLVTIEAEDILKS 282
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 173-518 3.70e-43

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 159.69  E-value: 3.70e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 173 RAARWSDVVKLLTPIVNDPALDQTFAHAAKITLGTALARLGMFAPALSYLEEPEGPVPVAALDGALAKALVLRAHVDEES 252
Cdd:COG0464    4 LLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLALLA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 253 AAEVLQDLYAAHPENEQVEQALSDTSFGIVTTTAARIEARTDPWDPETEPSADDFIDPAAHERKAALLHEAErqLAEFIG 332
Cdd:COG0464   84 ALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAI--LDDLGG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 333 LDEVKNQVSRLKSSVAMEL-VRKQRGLTvaqRTHHLIFAGPPGTGKTTIARVVAKIycgLGLlkreNIREVHRADLIGQH 411
Cdd:COG0464  162 LEEVKEELRELVALPLKRPeLREEYGLP---PPRGLLLYGPPGTGKTLLARALAGE---LGL----PLIEVDLSDLVSKY 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 412 IGETEAKTNAIIDSALD---GVLFLDEAYALVA--TGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRadldkFLDTNE 486
Cdd:COG0464  232 VGETEKNLREVFDKARGlapCVLFIDEADALAGkrGEVGDGVGRRVVNTLLTEMEELRSDVVVIAATNR-----PDLLDP 306

                        330       340       350
                 ....*....|....*....|....*....|..
gi 738459163 487 GLRSRFTRSIEFPSYTSHELVEIAHKMAEQRD 518
Cdd:COG0464  307 ALLRRFDEIIFFPLPDAEERLEIFRIHLRKRP 338
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
327-525 1.76e-23

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 99.57  E-value: 1.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 327 LAEFIGLDEVKNQVSRLKSSVAMELVRKQRGLTVAqrtHHLIFAGPPGTGKTTIARVVAkiycglGLLKRENIrEVHRAD 406
Cdd:COG1223    1 LDDVVGQEEAKKKLKLIIKELRRRENLRKFGLWPP---RKILFYGPPGTGKTMLAEALA------GELKLPLL-TVRLDS 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 407 LIGQHIGETEAKTNAIIDSA--LDGVLFLDEAYALVAT-GAKNDFGLVA--IDTLLARMENDRDRLVVIIAGYRADLdkf 481
Cdd:COG1223   71 LIGSYLGETARNLRKLFDFArrAPCVIFFDEFDAIAKDrGDQNDVGEVKrvVNALLQELDGLPSGSVVIAATNHPEL--- 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 738459163 482 LDtnEGLRSRFTRSIEFPSYTSHELVEIAHKMAEQRDSVFERSA 525
Cdd:COG1223  148 LD--SALWRRFDEVIEFPLPDKEERKEILELNLKKFPLPFELDL 189
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 367-499 7.68e-22

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 91.50  E-value: 7.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  367 LIFAGPPGTGKTTIARVVAKiYCGLgllkreNIREVHRADLIGQHIGETEAKTNAIIDSA---LDGVLFLDEAYALVATG 443
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAK-ELGA------PFIEISGSELVSKYVGESEKRLRELFEAAkklAPCVIFIDEIDALAGSR 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738459163  444 AKN--DFGLVAIDTLLARME---NDRDRLVVIIAGYRADLdkfLDtnEGLRSRFTRSIEFP 499
Cdd:pfam00004  74 GSGgdSESRRVVNQLLTELDgftSSNSKVIVIAATNRPDK---LD--PALLGRFDRIIEFP 129
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 347-500 1.19e-13

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 68.71  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 347 VAMELVRKQRGLTVAQRTH-HLIFAGPPGTGKTTIARVVAKIYcglgLLKRENIREVHRADLIGQHIGETEAKTNAIIDS 425
Cdd:cd00009    1 VGQEEAIEALREALELPPPkNLLLYGPPGTGKTTLARAIANEL----FRPGAPFLYLNASDLLEGLVVAELFGHFLVRLL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 426 ALD------GVLFLDEAYALvaTGAKNDFGLVAIDTLLARMEnDRDRLVVIIAGYRADLDKFLdtnEGLRSRFTRSIEFP 499
Cdd:cd00009   77 FELaekakpGVLFIDEIDSL--SRGAQNALLRVLETLNDLRI-DRENVRVIGATNRPLLGDLD---RALYDRLDIRIVIP 150


                 .
gi 738459163 500 S 500
Cdd:cd00009  151 L 151
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 259-509 1.30e-12

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 69.26  E-value: 1.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 259 DLYAAHPENEQVEQALSDTSFGIVTTTAARIEARTDPWDPETEPSADD------FIDPAAHERKAALLHEAERQLAEFIG 332
Cdd:COG1222    3 DLLTIDENIKALLALIDALQERLGVELALLLQPVKALELLEEAPALLLndanltQKRLGTPRGTAVPAESPDVTFDDIGG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 333 LDEVKNQVSRlksSVAMELVRKQRGLTV-AQRTHHLIFAGPPGTGKTTIARVVAKiYCGLGLLKrenireVHRADLIGQH 411
Cdd:COG1222   83 LDEQIEEIRE---AVELPLKNPELFRKYgIEPPKGVLLYGPPGTGKTLLAKAVAG-ELGAPFIR------VRGSELVSKY 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 412 IGETEAKTNAIIDSALD---GVLFLDEAYALVAT-GAKNDFGLVA--IDTLLARME--NDRDRLVVIIAGYRAD-LDKFL 482
Cdd:COG1222  153 IGEGARNVREVFELAREkapSIIFIDEIDAIAARrTDDGTSGEVQrtVNQLLAELDgfESRGDVLIIAATNRPDlLDPAL 232

                        250       260
                 ....*....|....*....|....*...
gi 738459163 483 dtnegLR-SRFTRSIEFPSYTSHELVEI 509
Cdd:COG1222  233 -----LRpGRFDRVIEVPLPDEEAREEI 255
PRK14953 PRK14953
DNA polymerase III subunits gamma and tau; Provisional
 362-565 3.19e-10

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237867 [Multi-domain]  Cd Length: 486  Bit Score: 62.92  E-value: 3.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 362 QRTHH-LIFAGPPGTGKTTIARVVAKIY----------CGlgllKRENIREVHRA---DLIgqhigETEAKTNAIID--- 424
Cdd:PRK14953  35 QRVSHaYIFAGPRGTGKTTIARILAKVLnclnpqegepCG----KCENCVEIDKGsfpDLI-----EIDAASNRGIDdir 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 425 SALDGVLF-----------LDEAYALVATgakndfglvAIDTLLARMENDRDRLVVIIAgyRADLDKFLDTnegLRSRFT 493
Cdd:PRK14953 106 ALRDAVSYtpikgkykvyiIDEAHMLTKE---------AFNALLKTLEEPPPRTIFILC--TTEYDKIPPT---ILSRCQ 171

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738459163 494 RSIeFPSYTSHELVEIAHKMAEQRDSVFERSALDhleaLFATLAASSTPDSNGInrrsLDIA---GNGRFVRNIV 565
Cdd:PRK14953 172 RFI-FSKPTKEQIKEYLKRICNEEKIEYEEKALD----LLAQASEGGMRDAASL----LDQAstyGEGKVTIKVV 237
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 339-498 4.91e-10

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 58.45  E-value: 4.91e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 339 QVSRLKSSVAMELVRKQRGLTVAQRTHHLIFAGPPGTGKTTIARVVAKiYCGLGLLKrenireVHRADLIGQHIGETEAK 418
Cdd:cd19481    1 LKASLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAG-ELGLPLIV------VKLSSLLSKYVGESEKN 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 419 TNAIIDSALD---GVLFLDEAYALVA---TGAKNDFGLVAIDTLLARMEND--RDRLVVIIAGYRAD-LDKFLdtnegLR 489
Cdd:cd19481   74 LRKIFERARRlapCILFIDEIDAIGRkrdSSGESGELRRVLNQLLTELDGVnsRSKVLVIAATNRPDlLDPAL-----LR 148

                        170
                 ....*....|
gi 738459163 490 S-RFTRSIEF 498
Cdd:cd19481  149 PgRFDEVIEF 158
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 332-498 3.09e-09

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 56.15  E-value: 3.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 332 GLDEvknQVSRLKSSVAMEL----VRKQRGLTVaqrTHHLIFAGPPGTGKTTIARVVAKiYCGLGLLKrenireVHRADL 407
Cdd:cd19503    4 GLDE---QIASLKELIELPLkypeLFRALGLKP---PRGVLLHGPPGTGKTLLARAVAN-EAGANFLS------ISGPSI 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 408 IGQHIGETEAKTNAIIDSALD---GVLFLDEAYALV----ATGAKNDFGLVAidTLLARME--NDRDRLVVIIAGYRADl 478
Cdd:cd19503   71 VSKYLGESEKNLREIFEEARShapSIIFIDEIDALApkreEDQREVERRVVA--QLLTLMDgmSSRGKVVVIAATNRPD- 147

                        170       180
                 ....*....|....*....|..
gi 738459163 479 dkflDTNEGLR--SRFTRSIEF 498
Cdd:cd19503  148 ----AIDPALRrpGRFDREVEI 165
rfc PRK00440
replication factor C small subunit; Reviewed
 325-441 2.80e-08

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 55.65  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 325 RQLAEFIGLDEVknqVSRLKSSVamelvrKQRGLTvaqrthHLIFAGPPGTGKTTIARVVAK-IYcglGLLKRENIREVH 403
Cdd:PRK00440  14 RTLDEIVGQEEI---VERLKSYV------KEKNMP------HLLFAGPPGTGKTTAALALAReLY---GEDWRENFLELN 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 738459163 404 RAD-----LIGQHIGETeAKTnAIIDSALDGVLFLDEAYALVA 441
Cdd:PRK00440  76 ASDergidVIRNKIKEF-ART-APVGGAPFKIIFLDEADNLTS 116
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 365-499 3.70e-08

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 52.76  E-value: 3.70e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163   365 HHLIFAGPPGTGKTTIARVVAKIY----CGLGLLKRENIREVHRADLIGQHIGETEAKT---------NAIIDSALDGVL 431
Cdd:smart00382   3 EVILIVGPPGSGKTTLARALARELgppgGGVIYIDGEDILEEVLDQLLLIIVGGKKASGsgelrlrlaLALARKLKPDVL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738459163   432 FLDEAYALVATGAKNDFGLVAIDTLLARMENDRDRLVVIIAGYRADLDKFLdtnegLRSRFTRSIEFP 499
Cdd:smart00382  83 ILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPAL-----LRRRFDRRIVLL 145
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 331-496 5.92e-07

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 49.66  E-value: 5.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 331 IGLDEVKnqvSRLKSSVAMELVRKQ--RGLTVAQRThhLIFAGPPGTGKTTIARVVAKiYCGLGLLKrenireVHRADLI 408
Cdd:cd19509    2 AGLDDAK---EALKEAVILPSLRPDlfPGLRGPPRG--ILLYGPPGTGKTLLARAVAS-ESGSTFFS------ISASSLV 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 409 GQHIGETEAKTNAIIDSA---LDGVLFLDEAYALVATGA----------KNDFgLVAIDTLLArmeNDRDRLVVIIAGYR 475
Cdd:cd19509   70 SKWVGESEKIVRALFALArelQPSIIFIDEIDSLLSERGsgeheasrrvKTEF-LVQMDGVLN---KPEDRVLVLGATNR 145

                        170       180
                 ....*....|....*....|..
gi 738459163 476 A-DLDkfldtnEGLRSRFTRSI 496
Cdd:cd19509  146 PwELD------EAFLRRFEKRI 161
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 367-478 5.97e-07

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 49.43  E-value: 5.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 367 LIFAGPPGTGKTTIARVVAKiYCGLgllkreNIREVHRADLIGQHIGETEAKTNAIIDSALDG---VLFLDEAYALV-AT 442
Cdd:cd19527   29 ILLYGPPGTGKTLLAKAIAT-ECSL------NFLSVKGPELINMYIGESEANVREVFQKARDAkpcVIFFDELDSLApSR 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 738459163 443 GAKNDFGLV---AIDTLLAR---MENDRDRLVVIIAGYRADL 478
Cdd:cd19527  102 GNSGDSGGVmdrVVSQLLAEldgMSSSGQDVFVIGATNRPDL 143
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 368-478 6.25e-07

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 49.59  E-value: 6.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 368 IFAGPPGTGKTTIARVVAKiYCGLgllkreNIREVHRADLIGQHIGETEAKTNAIIDSALDG---VLFLDEAYALVATGA 444
Cdd:cd19511   31 LLYGPPGCGKTLLAKALAS-EAGL------NFISVKGPELFSKYVGESERAVREIFQKARQAapcIIFFDEIDSLAPRRG 103

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 738459163 445 KNDFGLVA---IDTLLARME--NDRDRLVVIIAGYRADL 478
Cdd:cd19511  104 QSDSSGVTdrvVSQLLTELDgiESLKGVVVIAATNRPDM 142
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 325-386 1.00e-06

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 49.04  E-value: 1.00e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738459163  325 RQLAEFIGLDEVKNQVSrlkssVAMELVRkQRGLTVaqrtHHLIFAGPPGTGKTTIARVVAK 386
Cdd:pfam05496   4 RTLDEYIGQEKVKENLK-----IFIEAAK-QRGEAL----DHVLLYGPPGLGKTTLANIIAN 55
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 361-386 1.43e-06

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 50.85  E-value: 1.43e-06
                         10        20
                 ....*....|....*....|....*.
gi 738459163 361 AQRTHHLIFAGPPGTGKTTIARVVAK 386
Cdd:PRK13342  33 AGRLSSMILWGPPGTGKTTLARIIAG 58
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
308-386 1.64e-06

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 50.51  E-value: 1.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 308 IDPAAHERKAALLHEAER--QLAEFIGLDEVKNQVS-RLKSSvamelvrKQRGLTVaqrtHHLIFAGPPGTGKTTIARVV 384
Cdd:PRK00080   3 VSPETLEEEEDEIERSLRpkSLDEFIGQEKVKENLKiFIEAA-------KKRGEAL----DHVLLYGPPGLGKTTLANII 71


                 ..
gi 738459163 385 AK 386
Cdd:PRK00080  72 AN 73
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 365-436 2.07e-06

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 48.69  E-value: 2.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  365 HHLIFAGPPGTGKTTIARV---------------VAKIY--CGL----GLLKRENIREVH----RADLIGqhiGETEAKT 419
Cdd:pfam01078  23 HNLLMIGPPGSGKTMLAKRlpgilpplteaealeVTAIHsvAGLggdgGLIRRRPFRAPHhsasAAALVG---GGSIPRP 99

                          90
                  ....*....|....*...
gi 738459163  420 NAIidS-ALDGVLFLDEA 436
Cdd:pfam01078 100 GEI--SlAHNGVLFLDEL 115
PRK05896 PRK05896
DNA polymerase III subunits gamma and tau; Validated
 362-543 4.22e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235638 [Multi-domain]  Cd Length: 605  Bit Score: 49.84  E-value: 4.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 362 QRTHHLIFAGPPGTGKTTIARVVAKIYCGLGLLKRENIREVHRADLIGQH----IGETEAKTN-------AIIDSALD-- 428
Cdd:PRK05896  36 KLTHAYIFSGPRGIGKTSIAKIFAKAINCLNPKDGDCCNSCSVCESINTNqsvdIVELDAASNngvdeirNIIDNINYlp 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 429 -----GVLFLDEAYALvATGAKNdfglvaidTLLARMENDRDRLVVIIAgyRADLDKFLDTnegLRSRfTRSIEFPSYTS 503
Cdd:PRK05896 116 ttfkyKVYIIDEAHML-STSAWN--------ALLKTLEEPPKHVVFIFA--TTEFQKIPLT---IISR-CQRYNFKKLNN 180

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 738459163 504 HELVEIAHKMAEQRDSVFERSALDHLealfATLAASSTPD 543
Cdd:PRK05896 181 SELQELLKSIAKKEKIKIEDNAIDKI----ADLADGSLRD 216
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 325-565 4.37e-06

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 48.84  E-value: 4.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  325 RQLAEFIGLDEVKNQVS-RLKSSvamelvrKQRGLTVaqrtHHLIFAGPPGTGKTTIARVVA-------KIYCGLGLLKr 396
Cdd:TIGR00635   1 KLLAEFIGQEKVKEQLQlFIEAA-------KMRQEAL----DHLLLYGPPGLGKTTLAHIIAnemgvnlKITSGPALEK- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  397 enirevhRADLIGqhigeteaktnaiIDSALD--GVLFLDEAYAL------VATGAKNDFglvAIDTLLARMENDRDRlv 468
Cdd:TIGR00635  69 -------PGDLAA-------------ILTNLEegDVLFIDEIHRLspaveeLLYPAMEDF---RLDIVIGKGPSARSV-- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  469 viiagyRADLDKFL----DTNEG-----LRSRFTRSIEFPSYTSHELVEIAHKMAEQRDsvferSALDHLEALFATLAAS 539
Cdd:TIGR00635 124 ------RLDLPPFTlvgaTTRAGmltspLRDRFGIILRLEFYTVEELAEIVSRSAGLLN-----VEIEPEAALEIARRSR 192

                         250       260       270
                  ....*....|....*....|....*....|
gi 738459163  540 STPD-SNGINRRSLDIA---GNGRFVRNIV 565
Cdd:TIGR00635 193 GTPRiANRLLRRVRDFAqvrGQKIINRDIA 222
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 367-482 9.99e-06

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 45.96  E-value: 9.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 367 LIFAGPPGTGKTTIARVVAKiYCglgllkRENIREVHRADLIGQHIGETEAKTNAIIDSALDG---VLFLDE--AYALVA 441
Cdd:cd19528   30 VLFYGPPGCGKTLLAKAIAN-EC------QANFISVKGPELLTMWFGESEANVRDIFDKARAAapcVLFFDEldSIAKAR 102

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 738459163 442 TGAKNDFGLVA---IDTLLARME--NDRDRLVVIIAGYRAD-LDKFL 482
Cdd:cd19528  103 GGNIGDAGGAAdrvINQILTEMDgmNTKKNVFIIGATNRPDiIDPAI 149
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 367-498 1.44e-05

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 45.58  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 367 LIFAGPPGTGKTTIARVVAKiYCGLGLLKrenIREVHR--ADLIGQHIGETEAKTNAIIDSAL---DGVLFLDE--AYAL 439
Cdd:cd19517   37 VLFHGPPGTGKTLMARALAA-ECSKGGQK---VSFFMRkgADCLSKWVGEAERQLRLLFEEAYrmqPSIIFFDEidGLAP 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 738459163 440 VATGAKNDFGLVAIDTLLARME--NDRDRLVVIIAGYRADldkflDTNEGLR--SRFTRSIEF 498
Cdd:cd19517  113 VRSSKQEQIHASIVSTLLALMDglDNRGQVVVIGATNRPD-----ALDPALRrpGRFDREFYF 170
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 367-478 1.65e-05

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 45.56  E-value: 1.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 367 LIFAGPPGTGKTTIARVVAKiYCGLgllkreNIREVHRADLIGQHIGETEAKTNAIIDSALDG---VLFLDEAYALVATG 443
Cdd:cd19530   33 VLLYGPPGCGKTLLAKAVAN-ESGA------NFISVKGPELLNKYVGESERAVRQVFQRARASapcVIFFDEVDALVPKR 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 738459163 444 AKNDFGLVA--IDTLLARME--NDRDRLVVIIAGYRADL 478
Cdd:cd19530  106 GDGGSWASErvVNQLLTEMDglEERSNVFVIAATNRPDI 144
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 325-386 2.08e-05

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 47.00  E-value: 2.08e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738459163 325 RQLAEFIGLDEVKNQVSrlkssVAMELVrKQRGLTVaqrtHHLIFAGPPGTGKTTIARVVAK 386
Cdd:COG2255   25 KRLDEYIGQEKVKENLK-----IFIEAA-KKRGEAL----DHVLLYGPPGLGKTTLAHIIAN 76
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
321-386 2.40e-05

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 46.72  E-value: 2.40e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738459163 321 HEAERQLAEFIGLDEVKNQvsrLKSSVAmelvrkqrgltvAQRTHH-LIFAGPPGTGKTTIARVVAK 386
Cdd:COG2812    3 YQVPQTFDDVVGQEHVVRT---LKNALA------------SGRLAHaYLFTGPRGVGKTTLARILAK 54
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 361-386 4.04e-05

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 46.20  E-value: 4.04e-05
                         10        20
                 ....*....|....*....|....*.
gi 738459163 361 AQRTHHLIFAGPPGTGKTTIARVVAK 386
Cdd:COG2256   46 AGRLSSMILWGPPGTGKTTLARLIAN 71
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 365-436 4.63e-05

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 46.19  E-value: 4.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 365 HHLIFAGPPGTGKTTIAR---------------VVAKIY--CGL-----GLLKRENIREVH----RADLIGqhiGETEAK 418
Cdd:COG0606  212 HNLLMIGPPGSGKTMLARrlpgilpplteeealEVTAIHsvAGLlppdgGLIRRRPFRAPHhtasAAALVG---GGSIPR 288

                         90
                 ....*....|....*....
gi 738459163 419 TNAIidS-ALDGVLFLDEA 436
Cdd:COG0606  289 PGEI--SlAHNGVLFLDEL 305
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 366-435 5.76e-05

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 43.44  E-value: 5.76e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738459163  366 HLIFAGPPGTGKTTIARVVAKIYCGLGLLKRENIREVHRADLIGQHI---GETEAKTNAIIDSALDG-VLFLDE 435
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAALSNRPVFYVQLTRDTTEEDLFGRRNidpGGASWVDGPLVRAAREGeIAVLDE 74
PRK14962 PRK14962
DNA polymerase III subunits gamma and tau; Provisional
 364-386 4.22e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237869 [Multi-domain]  Cd Length: 472  Bit Score: 43.22  E-value: 4.22e-04
                         10        20
                 ....*....|....*....|...
gi 738459163 364 THHLIFAGPPGTGKTTIARVVAK 386
Cdd:PRK14962  36 SHAYIFAGPRGTGKTTVARILAK 58
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 367-496 5.13e-04

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 41.51  E-value: 5.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 367 LIFaGPPGTGKTTIARVVAKiYCGLGLLKrenireVHRADLIGQHIGETEAKTNAIIDSA---LDGVLFLDEAYALVATG 443
Cdd:cd19525   59 LLF-GPPGTGKTLIGKCIAS-QSGATFFS------ISASSLTSKWVGEGEKMVRALFSVArckQPAVIFIDEIDSLLSQR 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 738459163 444 A----------KNDFgLVAIDTLLARMEndrDRLVVIIAGYRADldkflDTNEGLRSRFTRSI 496
Cdd:cd19525  131 GegehessrriKTEF-LVQLDGATTSSE---DRILVVGATNRPQ-----EIDEAARRRLVKRL 184
RecD COG0507
ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) ...
 314-393 5.18e-04

ATPase/5#-3# helicase helicase subunit RecD of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];


Pssm-ID: 440273 [Multi-domain]  Cd Length: 514  Bit Score: 43.04  E-value: 5.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 314 ERKAALLHEAERQLAEFI--------GLDEVKNQVSRLKSSVAMELVRKQRGL--TVAQRTHHLIFAGPPGTGKTTIARV 383
Cdd:COG0507   80 RRYLTRLLEAEQRLARRLrrlarpalDEADVEAALAALEPRAGITLSDEQREAvaLALTTRRVSVLTGGAGTGKTTTLRA 159

                         90
                 ....*....|
gi 738459163 384 VAKIYCGLGL 393
Cdd:COG0507  160 LLAALEALGL 169
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
371-554 5.20e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 42.91  E-value: 5.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 371 GPPGTGKTTIARVVAKIYCGLGLLKRENIREVH----RAD-------LIGQHIGE----------TEAKTNAIID--SAL 427
Cdd:COG1474   58 GPTGTGKTAVAKYVLEELEEEAEERGVDVRVVYvncrQAStryrvlsRILEELGSgedipstglsTDELFDRLYEalDER 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 428 DGVLF--LDEAYALVATgakndfglvAIDTLL-----ARMENDRDRLVVIIAGYRADLDKFLDtnEGLRSRFT-RSIEFP 499
Cdd:COG1474  138 DGVLVvvLDEIDYLVDD---------EGDDLLyqllrANEELEGARVGVIGISNDLEFLENLD--PRVKSSLGeEEIVFP 206

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 738459163 500 SYTSHELVEIAHKMAEQ--RDSVFERSALDHLealfATLAASSTPDSnginRRSLDI 554
Cdd:COG1474  207 PYDADELRDILEDRAELafYDGVLSDEVIPLI----AALAAQEHGDA----RKAIDL 255
PRK13341 PRK13341
AAA family ATPase;
325-385 6.20e-04

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 42.73  E-value: 6.20e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738459163 325 RQLAEFIGLDEVKNQVSRLKSSVAmelvrkqrgltvAQRTHHLIFAGPPGTGKTTIARVVA 385
Cdd:PRK13341  25 RTLEEFVGQDHILGEGRLLRRAIK------------ADRVGSLILYGPPGVGKTTLARIIA 73
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 216-390 7.43e-04

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 42.45  E-value: 7.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 216 APALSYLEEPEGPVPVAALDGALAKALVLRAHVDEESAAEVLQDLYAAHPENEQVEQALSDTSFGIVTTTAARIEARTDP 295
Cdd:COG1401  100 AIEELYELEADSEIEAVGLLLELAERSDALEALERARLLLELADLEERAALETEVLEALEAELEELLAAPEDLSADALAA 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 296 WDPETEPSADDFIDPAAHERKAALLHEAERQLAEFIGLDEVKNQVsrlkssvamelvrkqrgltvaqrthhlIFAGPPGT 375
Cdd:COG1401  180 ELSAAEELYSEDLESEDDYLKDLLREKFEETLEAFLAALKTKKNV---------------------------ILAGPPGT 232

                        170
                 ....*....|....*
gi 738459163 376 GKTTIARVVAKIYCG 390
Cdd:COG1401  233 GKTYLARRLAEALGG 247
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 371-499 8.13e-04

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 40.50  E-value: 8.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 371 GPPGTGKTTIARVVAKIYCGLGLLkrenireVHRADLIGQHIGETEAKTNAIIDSALD---GVLFLDEAYALVATGAK-- 445
Cdd:cd19519   41 GPPGTGKTLIARAVANETGAFFFL-------INGPEIMSKLAGESESNLRKAFEEAEKnapAIIFIDEIDAIAPKREKth 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 738459163 446 NDFGLVAIDTLLARME--NDRDRLVVIIAGYRADldkflDTNEGLR--SRFTRSIEFP 499
Cdd:cd19519  114 GEVERRIVSQLLTLMDglKQRAHVIVMAATNRPN-----SIDPALRrfGRFDREIDIG 166
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 332-498 8.30e-04

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 40.40  E-value: 8.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 332 GLDEvknQVSRLKSSVAMELVRKQR--GLTVAQRTHHLIFaGPPGTGKTTIARVVAkiycglgllKREN---IReVHRAD 406
Cdd:cd19502    7 GLDE---QIREIREVVELPLKHPELfeELGIEPPKGVLLY-GPPGTGKTLLAKAVA---------NHTDatfIR-VVGSE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 407 LIGQHIGETEAKTNAIIDSALD---GVLFLDEAYALVA------TGAKNDFGLVAIDtLLARME--NDRDRLVVIIAGYR 475
Cdd:cd19502   73 LVQKYIGEGARLVRELFEMAREkapSIIFIDEIDAIGAkrfdsgTGGDREVQRTMLE-LLNQLDgfDPRGNIKVIMATNR 151

                        170       180
                 ....*....|....*....|....*
gi 738459163 476 AD-LDKFLdtnegLR-SRFTRSIEF 498
Cdd:cd19502  152 PDiLDPAL-----LRpGRFDRKIEF 171
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 320-386 9.22e-04

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 40.62  E-value: 9.22e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 738459163 320 LHEAERQL-AEFIGLDEVKNQVsrlkssvaMELvrkqrgLTVAQRTHH-----LIFAGPPGTGKTTIARVVAK 386
Cdd:cd19500    1 IKKARKVLdADHYGLEDVKERI--------LEY------LAVRKLKGSmkgpiLCLVGPPGVGKTSLGKSIAR 59
AAA_18 pfam13238
AAA domain;
368-471 1.21e-03

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 39.33  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  368 IFAGPPGTGKTTIARVVAKIyCGLGLLKRENIREVHRADLIGQHIGETEAKTNAIIDSALDgvlfldeayALVATGAKND 447
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKR-LGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLD---------LLEENAALEE 71

                          90       100
                  ....*....|....*....|....
gi 738459163  448 FGLVAIDTLLARMENDRDRLVVII 471
Cdd:pfam13238  72 GGNLIIDGHLAELEPERAKDLVGI 95
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 332-499 1.22e-03

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 41.82  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  332 GLDEVKNQVSR-----LKSSVAMEL--VRKQRGLtvaqrthhLIFaGPPGTGKTTIARVVAKiycglglLKRENIREVHR 404
Cdd:TIGR01243 457 GLEEVKQELREavewpLKHPEIFEKmgIRPPKGV--------LLF-GPPGTGKTLLAKAVAT-------ESGANFIAVRG 520

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163  405 ADLIGQHIGETEAKTNAIIDSALDG---VLFLDEAYAlVATGAKNDFGLVAIDTLLARMENDRDRL------VVIIAGYR 475
Cdd:TIGR01243 521 PEILSKWVGESEKAIREIFRKARQAapaIIFFDEIDA-IAPARGARFDTSVTDRIVNQLLTEMDGIqelsnvVVIAATNR 599

                         170       180
                  ....*....|....*....|....*.
gi 738459163  476 AD-LDKFLdtnegLR-SRFTRSIEFP 499
Cdd:TIGR01243 600 PDiLDPAL-----LRpGRFDRLILVP 620
AAA_lid_6 pfam17866
AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 556-600 1.26e-03

AAA lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465539 [Multi-domain]  Cd Length: 60  Bit Score: 37.54  E-value: 1.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 738459163  556 GNGRFVRNIVERAEEEREFRLdhsehAGTGEFSDDELMTITAADV 600
Cdd:pfam17866  21 GNARFVRNLLERAIRRQALRL-----AAEEELTREDLMTLTAEDF 60
PRK04195 PRK04195
replication factor C large subunit; Provisional
 367-529 1.88e-03

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 41.06  E-value: 1.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 367 LIFAGPPGTGKTTIARVVAKIYcGLGLLkrE-NIREVHRADLIGQHIGetEAKTNAIIDSALDGVLFLDEAYALvatGAK 445
Cdd:PRK04195  42 LLLYGPPGVGKTSLAHALANDY-GWEVI--ElNASDQRTADVIERVAG--EAATSGSLFGARRKLILLDEVDGI---HGN 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 446 NDFGLV-AIDTLLARMENDrdrlVVIIAGyradlDKFLDTNEGLRSRfTRSIEFPSYTSHELVEIAHKMAEQRDSVFERS 524
Cdd:PRK04195 114 EDRGGArAILELIKKAKQP----IILTAN-----DPYDPSLRELRNA-CLMIEFKRLSTRSIVPVLKRICRKEGIECDDE 183


                 ....*
gi 738459163 525 ALDHL 529
Cdd:PRK04195 184 ALKEI 188
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 332-386 2.65e-03

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 38.94  E-value: 2.65e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 738459163 332 GLDEVKNQvsrLKSSVAMELVRKQ----RGLTVAQRThhLIFAGPPGTGKTTIARVVAK 386
Cdd:cd19520    4 GLDEVITE---LKELVILPLQRPElfdnSRLLQPPKG--VLLYGPPGCGKTMLAKATAK 57
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 367-496 2.95e-03

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 38.92  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 367 LIFAGPPGTGKTTIARVVAkiycglGLLKRENIrEVHRADLIGQHIGETEAKTNAIIDSALDG---VLFLDEAYALVAT- 442
Cdd:cd19518   37 VLLHGPPGCGKTMLANAIA------GELKVPFL-KISATEIVSGVSGESEEKIRELFDQAISNapcIVFIDEIDAITPKr 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 738459163 443 -GAKNDFGLVAIDTLLARMEN------DRDRLVVIIAGYRADLdkfLDTneGLR--SRFTRSI 496
Cdd:cd19518  110 eSAQREMERRIVSQLLTCMDElnnektAGGPVLVIGATNRPDS---LDP--ALRraGRFDREI 167
DEXXQc_Upf1-like cd17934
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ...
 371-436 4.97e-03

DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438708 [Multi-domain]  Cd Length: 121  Bit Score: 37.21  E-value: 4.97e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738459163 371 GPPGTGKT-TIARVVAKiycglgLLKRENIREVhradLIGqhigeteAKTNAIIDsALDgVLFLDEA 436
Cdd:cd17934    6 GPPGTGKTtTIAAIVLQ------LLKGLRGKRV----LVT-------AQSNVAVD-NVD-VVIIDEA 53
PRK05563 PRK05563
DNA polymerase III subunits gamma and tau; Validated
 365-386 5.32e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235505 [Multi-domain]  Cd Length: 559  Bit Score: 39.85  E-value: 5.32e-03
                         10        20
                 ....*....|....*....|..
gi 738459163 365 HHLIFAGPPGTGKTTIARVVAK 386
Cdd:PRK05563  39 HAYLFSGPRGTGKTSAAKIFAK 60
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 367-456 8.15e-03

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 37.78  E-value: 8.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738459163 367 LIFAGPPGTGKTTIARVVAKIycglglLKRENIREVH-RADLIGQHIGETEAKTNAIIDsaldgvLFLDEAYALVATGAK 445
Cdd:COG4088    7 LILTGPPGSGKTTFAKALAQR------LYAEGIAVALlHSDDFRRFLVNESFPKETYEE------VVEDVRTTTADNALD 74

                         90
                 ....*....|.
gi 738459163 446 NDFGLVAIDTL 456
Cdd:COG4088   75 NGYSVIVDGTF 85
PRK06305 PRK06305
DNA polymerase III subunits gamma and tau; Validated
 328-386 9.02e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180523 [Multi-domain]  Cd Length: 451  Bit Score: 38.99  E-value: 9.02e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 738459163 328 AEFIGLDEVknqVSRLKSSVamelvRKQRgltVAqrtHHLIFAGPPGTGKTTIARVVAK 386
Cdd:PRK06305  17 SEILGQDAV---VAVLKNAL-----RFNR---AA---HAYLFSGIRGTGKTTLARIFAK 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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