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Conserved domains on  [gi|738387631|ref|WP_036339517|]
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MULTISPECIES: cystathionine gamma-synthase [Micrococcus]

Protein Classification

PLP-dependent aminotransferase family protein( domain architecture ID 139552)

PLP-dependent aminotransferase family protein may combine pyridoxal phosphate with an alpha-amino acid to form a Schiff base or aldimine intermediate, which then acts as the substrate in a reaction such as a transamination, racemization, or decarboxylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 12-399 0e+00

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member PRK07811:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 388  Bit Score: 624.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  12 SRPAVRGFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASG 91
Cdd:PRK07811   6 DHHANQGFATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGLRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  92 LAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIAD 171
Cdd:PRK07811  86 MAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITP-RTKLIWVETPTNPLLSITD 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 172 LAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAG 251
Cdd:PRK07811 165 IAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEE-----LDEAFAFLQNGAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 252 AVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAA 331
Cdd:PRK07811 240 AVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEA 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738387631 332 ARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK07811 320 ARDFCARTKVFTLAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDVADLLADLEQALG 387
 
Name Accession Description Interval E-value
PRK07811 PRK07811
cystathionine gamma-synthase; Provisional
 12-399 0e+00

cystathionine gamma-synthase; Provisional


Pssm-ID: 236104 [Multi-domain]  Cd Length: 388  Bit Score: 624.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  12 SRPAVRGFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASG 91
Cdd:PRK07811   6 DHHANQGFATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGLRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  92 LAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIAD 171
Cdd:PRK07811  86 MAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITP-RTKLIWVETPTNPLLSITD 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 172 LAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAG 251
Cdd:PRK07811 165 IAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEE-----LDEAFAFLQNGAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 252 AVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAA 331
Cdd:PRK07811 240 AVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEA 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738387631 332 ARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK07811 320 ARDFCARTKVFTLAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDVADLLADLEQALG 387
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 18-399 0e+00

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 548.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRA-------GHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:COG0626    2 GPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAArfageegGYIYSRYGNPTRRALEEALAALEGGEAALAFAS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIA 170
Cdd:COG0626   82 GMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRP-NTKLVFLETPSNPTLEVV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAA 250
Cdd:COG0626  161 DIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEE-----LAERLRFLQNAL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 251 GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEA 330
Cdd:COG0626  236 GAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGRE 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738387631 331 AARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGT---PLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:COG0626  316 AARRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEeraALGITDGLVRLSVGLEDVDDLIADLEQALA 387
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 21-399 9.40e-171

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 483.27  E-value: 9.40e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   21 TTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRaGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLR 100
Cdd:pfam01053   2 TLAVHAGQRPDPQTGAVSVPIYLTSTYVFDFAGEEG-GYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITAAIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  101 AVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQIAH 180
Cdd:pfam01053  81 ALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKP-NTKAVYLETPTNPLLKVVDIEAIAKLAK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  181 DAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGPQDSY 260
Cdd:pfam01053 160 KHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEE-----LGKELYFLQNATGAVLSPFDAW 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  261 LAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFAEATE 340
Cdd:pfam01053 235 LLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLK 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738387631  341 LFALSVSLGGVESLLCYSSEMTHASVRGTPLAVPT---DLVRLSVGIEDVADLQADLEAGLE 399
Cdd:pfam01053 315 LFSLAVSLGGVESLISHPATMTHASIPPEEREAAGitdDLIRLSVGIEDVDDLIADLKQALE 376
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 35-399 5.25e-157

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 448.19  E-value: 5.25e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  35 GAVVPPIYQTSTFVQDGINVLRA-------GHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLRAVLRPGD 107
Cdd:cd00614    1 GAVAPPIYQTSTFVFPSPAEAADlfalregGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 108 HIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQIAHDAGALLV 187
Cdd:cd00614   81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKP-ETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 188 VDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVadrefRGRALAEAVAYQQFAAGAVAGPQDSYLAARGLK 267
Cdd:cd00614  160 VDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVG-----SGEALIQRLRFLRLALGTILSPFDAWLLLRGLK 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 268 TLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFAEATELFALSVS 347
Cdd:cd00614  235 TLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVS 314

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 738387631 348 LGGVESLLCYSSEMTHASVRGTP---LAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:cd00614  315 LGGVESLVEHPASMTHSQLPPEEraaAGITPGLVRLSVGIEDVEDLIADLEQALK 369
O_succ_thio_ly TIGR02080
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ...
 21-398 2.19e-113

O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 131135  Cd Length: 382  Bit Score: 337.54  E-value: 2.19e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   21 TTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRAgHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLR 100
Cdd:TIGR02080   6 TIAVRSGLNSDTQYGCVVPPIYLSTTYNFTGFNEPRA-YDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVTT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  101 AVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQIAH 180
Cdd:TIGR02080  85 ALLGPDDLLVAPHDCYGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQ-KPKLVLIETPSNPLLRVVDIAKICHLAK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  181 DAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGPQDSY 260
Cdd:TIGR02080 164 AVGAVVVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQ-----VAEELAWWANNLGVTGGAFDSY 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  261 LAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFAEATE 340
Cdd:TIGR02080 239 LTLRGLRTLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLGGLS 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738387631  341 LFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVRLSVGIEDVADLQADLEAGL 398
Cdd:TIGR02080 319 LFTLAESLGGVESLIAHPATMTHAAMGPEARAeagISDTLLRLSVGLEDADDLIADLEQGL 379
 
Name Accession Description Interval E-value
PRK07811 PRK07811
cystathionine gamma-synthase; Provisional
 12-399 0e+00

cystathionine gamma-synthase; Provisional


Pssm-ID: 236104 [Multi-domain]  Cd Length: 388  Bit Score: 624.75  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  12 SRPAVRGFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASG 91
Cdd:PRK07811   6 DHHANQGFATRAIHAGYEPDPATGAVNPPIYASSTFAQDGVGGLRGGYEYARTGNPTRTALEEQLAALEGGAYGRAFSSG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  92 LAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIAD 171
Cdd:PRK07811  86 MAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITP-RTKLIWVETPTNPLLSITD 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 172 LAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAG 251
Cdd:PRK07811 165 IAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEE-----LDEAFAFLQNGAG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 252 AVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAA 331
Cdd:PRK07811 240 AVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVRLAGGEEA 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738387631 332 ARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK07811 320 ARDFCARTKVFTLAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDVADLLADLEQALG 387
MetC COG0626
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ...
 18-399 0e+00

Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440391 [Multi-domain]  Cd Length: 389  Bit Score: 548.50  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRA-------GHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:COG0626    2 GPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAArfageegGYIYSRYGNPTRRALEEALAALEGGEAALAFAS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIA 170
Cdd:COG0626   82 GMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRP-NTKLVFLETPSNPTLEVV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAA 250
Cdd:COG0626  161 DIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEE-----LAERLRFLQNAL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 251 GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEA 330
Cdd:COG0626  236 GAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFELKGGRE 315

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738387631 331 AARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGT---PLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:COG0626  316 AARRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEeraALGITDGLVRLSVGLEDVDDLIADLEQALA 387
Cys_Met_Meta_PP pfam01053
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ...
 21-399 9.40e-171

Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.


Pssm-ID: 395837 [Multi-domain]  Cd Length: 376  Bit Score: 483.27  E-value: 9.40e-171
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   21 TTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRaGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLR 100
Cdd:pfam01053   2 TLAVHAGQRPDPQTGAVSVPIYLTSTYVFDFAGEEG-GYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAITAAIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  101 AVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQIAH 180
Cdd:pfam01053  81 ALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKP-NTKAVYLETPTNPLLKVVDIEAIAKLAK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  181 DAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGPQDSY 260
Cdd:pfam01053 160 KHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEE-----LGKELYFLQNATGAVLSPFDAW 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  261 LAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFAEATE 340
Cdd:pfam01053 235 LLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEAAKKFLDNLK 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738387631  341 LFALSVSLGGVESLLCYSSEMTHASVRGTPLAVPT---DLVRLSVGIEDVADLQADLEAGLE 399
Cdd:pfam01053 315 LFSLAVSLGGVESLISHPATMTHASIPPEEREAAGitdDLIRLSVGIEDVDDLIADLKQALE 376
CGS_like cd00614
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ...
 35-399 5.25e-157

CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.


Pssm-ID: 99738 [Multi-domain]  Cd Length: 369  Bit Score: 448.19  E-value: 5.25e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  35 GAVVPPIYQTSTFVQDGINVLRA-------GHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLRAVLRPGD 107
Cdd:cd00614    1 GAVAPPIYQTSTFVFPSPAEAADlfalregGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 108 HIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQIAHDAGALLV 187
Cdd:cd00614   81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKP-ETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 188 VDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVadrefRGRALAEAVAYQQFAAGAVAGPQDSYLAARGLK 267
Cdd:cd00614  160 VDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVG-----SGEALIQRLRFLRLALGTILSPFDAWLLLRGLK 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 268 TLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFAEATELFALSVS 347
Cdd:cd00614  235 TLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFELKGGLEAAKKFLNALKLFSLAVS 314

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 738387631 348 LGGVESLLCYSSEMTHASVRGTP---LAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:cd00614  315 LGGVESLVEHPASMTHSQLPPEEraaAGITPGLVRLSVGIEDVEDLIADLEQALK 369
PRK07671 PRK07671
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
21-399 9.38e-137

bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;


Pssm-ID: 181076 [Multi-domain]  Cd Length: 377  Bit Score: 397.17  E-value: 9.38e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  21 TTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRaGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLr 100
Cdd:PRK07671   5 TKLIHGGIIGDPSTGAVSVPIYQVSTYKQEAVGKHQ-GYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVM- 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 101 AVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQIAH 180
Cdd:PRK07671  83 MLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRP-NTKAIYVETPTNPLLKITDIKKISTIAK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 181 DAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGPQDSY 260
Cdd:PRK07671 162 EKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPE-----LAEDLHFVQNSTGGILGPQDSW 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 261 LAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLaGGEAAARAFAEATE 340
Cdd:PRK07671 237 LLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDV-GSEETANKVLERLQ 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738387631 341 LFALSVSLGGVESLLCYSSEMTHASV---RGTPLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK07671 316 YFTLAESLGAVESLISIPSQMTHASIpadRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
MET17 COG2873
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ...
 18-399 4.42e-127

O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 442120 [Multi-domain]  Cd Length: 428  Bit Score: 374.37  E-value: 4.42e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFV----QDGINV--LRA-GHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:COG2873    7 GFETLALHAGQEPDPTTGARAVPIYQTTSYVfddaEHAADLfaLKEpGNIYTRIMNPTTDVLEKRIAALEGGVAALATAS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIA 170
Cdd:COG2873   87 GQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDP-NTKAIFGETIGNPALDVL 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVA-----------------DRE 233
Cdd:COG2873  166 DIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGgnfdwaangkfpeltepDPS 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 234 FRGRALAEAVAYQQFAA----------GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPD 303
Cdd:COG2873  246 YHGLVYTEAFGNAAFITkarvqllrdlGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLPS 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 304 HPGHALAARQM-DGFGGIVSIRLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVR 379
Cdd:COG2873  326 HPYHELAQKYLpKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAaagVTPDLIR 405

                        410       420
                 ....*....|....*....|
gi 738387631 380 LSVGIEDVADLQADLEAGLE 399
Cdd:COG2873  406 LSVGIEDIDDIIADLDQALA 425
PRK06176 PRK06176
cystathionine gamma-synthase;
19-399 2.25e-125

cystathionine gamma-synthase;


Pssm-ID: 180443 [Multi-domain]  Cd Length: 380  Bit Score: 368.07  E-value: 2.25e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  19 FTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRaGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDAL 98
Cdd:PRK06176   3 MQTKLIHGGISEDTTTGAVSVPIYQTSTYRQDAIGRPK-GYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  99 LrAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQI 178
Cdd:PRK06176  82 F-SLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKP-NTKALYLETPSNPLLKITDLAQCASV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 179 AHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGPQD 258
Cdd:PRK06176 160 AKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEA-----LAQEIAFFQNAIGGVLGPQD 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 259 SYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFAEA 338
Cdd:PRK06176 235 SWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSEAVAFVESL 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738387631 339 tELFALSVSLGGVESLLCYSSEMTHASVRGT---PLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK06176 315 -KLFILGESLGGVESLVGIPAFMTHACIPKEqreAAGIRDGLVRLSVGIEHEQDLLEDLEQAFA 377
PRK08064 PRK08064
cystathionine beta-lyase MetC;
19-399 3.21e-119

cystathionine beta-lyase MetC;


Pssm-ID: 236146 [Multi-domain]  Cd Length: 390  Bit Score: 352.92  E-value: 3.21e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  19 FTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRAgHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAA-EDA 97
Cdd:PRK08064   7 IDTLLLHNQYKHDKQTGAVNVPIYHASTFHQFDFDTFGK-YDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAiSTA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  98 LLraVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPGrTALLWVETPSNPLLGIADLAAWAQ 177
Cdd:PRK08064  86 FL--LLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPN-TKLFYVETPSNPLLKVTDIRGVVK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 178 IAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGPQ 257
Cdd:PRK08064 163 LAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEE-----LAQKLYFLQNSFGAVLGVQ 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 258 DSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLaGGEAAARAFAE 337
Cdd:PRK08064 238 DCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTL-QSEEAVRQFVS 316

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738387631 338 ATELFALSVSLGGVESLLCYSSEMTHASV-------RGtplaVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK08064 317 HVKLPVFAVSLGAVESILSYPAKMSHAAMpkeerdeRG----ITDGLLRLSVGLENVDDLIADFEQALS 381
O_succ_thio_ly TIGR02080
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ...
 21-398 2.19e-113

O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 131135  Cd Length: 382  Bit Score: 337.54  E-value: 2.19e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   21 TTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRAgHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLR 100
Cdd:TIGR02080   6 TIAVRSGLNSDTQYGCVVPPIYLSTTYNFTGFNEPRA-YDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVTT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  101 AVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQIAH 180
Cdd:TIGR02080  85 ALLGPDDLLVAPHDCYGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQ-KPKLVLIETPSNPLLRVVDIAKICHLAK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  181 DAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGPQDSY 260
Cdd:TIGR02080 164 AVGAVVVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQ-----VAEELAWWANNLGVTGGAFDSY 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  261 LAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFAEATE 340
Cdd:TIGR02080 239 LTLRGLRTLVARMRLQQRNAQAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFELKGGEQTVRRFLGGLS 318

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738387631  341 LFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVRLSVGIEDVADLQADLEAGL 398
Cdd:TIGR02080 319 LFTLAESLGGVESLIAHPATMTHAAMGPEARAeagISDTLLRLSVGLEDADDLIADLEQGL 379
cysta_beta_ly_E TIGR01329
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ...
 21-398 1.33e-112

cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.


Pssm-ID: 273557 [Multi-domain]  Cd Length: 378  Bit Score: 335.65  E-value: 1.33e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   21 TTAVHAGQEPDPLtGAVVPPIYQTSTFVQDGINVlRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLR 100
Cdd:TIGR01329   3 TLLVNTDNKNDPY-DASSMPIYQTATFKQPLAIE-NGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  101 aVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQIAH 180
Cdd:TIGR01329  81 -LLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGP-KTKLVLLESPTNPLQKIVDIRKISEMAH 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  181 DAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGPQDSY 260
Cdd:TIGR01329 159 AQNALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEE-----IAKKVYFLQNSTGSGLAPFDCW 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  261 LAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRlAGGEAAARAFAEATE 340
Cdd:TIGR01329 234 LLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFE-TGSVALSKRLVEATK 312

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738387631  341 LFALSVSLGGVESLLCYSSEMTHASV-------RGtplaVPTDLVRLSVGIEDVADLQADLEAGL 398
Cdd:TIGR01329 313 LFSITVSFGSVNSLISMPCFMSHASIpaevreeRG----LPEDLVRLSVGIEDVDDLISDLDIAF 373
met_gam_lyase TIGR01328
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ...
 18-399 1.55e-112

methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]


Pssm-ID: 130395 [Multi-domain]  Cd Length: 391  Bit Score: 335.70  E-value: 1.55e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFV----QDGINVL---RAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:TIGR01328   3 TFATRAIHAGYPPKDQFGALTPPIYQTSTFVfdscEQGGNRFagqESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIA 170
Cdd:TIGR01328  83 GMGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKD-NTKIVYFETPANPTMKLI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGaVVVADREFRGRAlaeAVAYQQFAA 250
Cdd:TIGR01328 162 DMERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAG-LICGKAELLQQI---RMVGIKDMT 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  251 GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEA 330
Cdd:TIGR01328 238 GSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFELKGGFA 317

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738387631  331 AARAFAEATELFALSVSLGGVESLLCYSSEMTHASV---RGTPLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:TIGR01328 318 GAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVpkeEREAAGITDGMIRLSVGLEDADDLIADLKQALD 389
PRK07503 PRK07503
methionine gamma-lyase; Provisional
 13-399 3.37e-111

methionine gamma-lyase; Provisional


Pssm-ID: 181005 [Multi-domain]  Cd Length: 403  Bit Score: 332.92  E-value: 3.37e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  13 RPAVRGFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINV-------LRAGHEYSRGSNPTRNGFETQLAALEHGDRA 85
Cdd:PRK07503   4 SHNNTGFSTRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEYgaecfagEEEGHFYSRISNPTLALLEQRMASLEGGEAA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  86 FAFASGLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNP 165
Cdd:PRK07503  84 VALASGMGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISD-KTRMVYFETPANP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 166 LLGIADLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVvadrefRGRALAEAVAY 245
Cdd:PRK07503 163 NMRLVDIAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVV------GGKALADRIRL 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 246 QQFA--AGAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSI 323
Cdd:PRK07503 237 EGLKdmTGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAF 316

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 738387631 324 RLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK07503 317 ELKGGIAAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAehgISEGLVRLSVGLEDVADILADLAQALD 395
PRK08133 PRK08133
O-succinylhomoserine sulfhydrylase; Validated
 18-398 1.95e-109

O-succinylhomoserine sulfhydrylase; Validated


Pssm-ID: 181244 [Multi-domain]  Cd Length: 390  Bit Score: 327.73  E-value: 1.95e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLtGAVVPPIYQTSTFVQDGINVLRA-------GHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:PRK08133   6 GFDTLAVRAGQLRSPF-GEHSEALFLTSSFVFESAAEAAArfageepGNIYSRFTNPTVTMFQERLAALEGAEACVATAS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIA 170
Cdd:PRK08133  85 GMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRP-NTKLFFLETPSNPLTELA 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAvVVADREFrgraLAEAVAYQQfAA 250
Cdd:PRK08133 164 DIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGA-VVGSKEL----MEEVFGFLR-TA 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 251 GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEA 330
Cdd:PRK08133 238 GPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFEVKGGRE 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 738387631 331 AARAFAEATELFALSVSLGGVESLLCYSSEMTHAsvRGTPLA-----VPTDLVRLSVGIEDVADLQADLEAGL 398
Cdd:PRK08133 318 AAWRVIDATRLISITANLGDTKTTITHPATTTHG--RLSPEAraaagITEGLIRVAVGLEDVADIKADLARGL 388
PRK08247 PRK08247
methionine biosynthesis PLP-dependent protein;
21-399 6.17e-109

methionine biosynthesis PLP-dependent protein;


Pssm-ID: 181320 [Multi-domain]  Cd Length: 366  Bit Score: 325.89  E-value: 6.17e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  21 TTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVlRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLr 100
Cdd:PRK08247   7 TKLAQIGNRSDERTGTVNPPVYFSTAYRHEGIGE-STGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQLVM- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 101 AVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQIAH 180
Cdd:PRK08247  85 SLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITP-NTKAIFIETPTNPLMQETDIAAIAKIAK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 181 DAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVadrefRGRALAEAVAYQQFAAGAVAGPQDSY 260
Cdd:PRK08247 164 KHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVA-----KGQELCERLAYYQNAAGAVLSPFDSW 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 261 LAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLpdhpghalaarqmdgfGGIVSIRLAGGEAAARAFAEAtE 340
Cdd:PRK08247 239 LLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPGR----------------GGMLSFRLQDEEWVNPFLKSL-K 301

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738387631 341 LFALSVSLGGVESLLCYSSEMTHASV-------RGtplaVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK08247 302 LITFAESLGGVESFITYPATQTHADIpeeiriaNG----VCNRLLRFSVGIENVEDLIADLKQAFK 363
PRK06234 PRK06234
methionine gamma-lyase; Provisional
 18-399 3.89e-108

methionine gamma-lyase; Provisional


Pssm-ID: 168478 [Multi-domain]  Cd Length: 400  Bit Score: 324.86  E-value: 3.89e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGIN-------VLRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:PRK06234   8 GFATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEqggrrfaGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPGrTALLWVETPSNPLLGIA 170
Cdd:PRK06234  88 GMGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKAN-TKVVYLETPANPTLKVT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DLAAWAQIAHDA--GALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGaVVVADREFRGRALAEAVayqQF 248
Cdd:PRK06234 167 DIKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAG-FVVGKEEFINQVKLFGI---KD 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 249 AAGAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGG 328
Cdd:PRK06234 243 MTGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFELKGG 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738387631 329 EAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK06234 323 VEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKeagISDGLVRLSVGLEDVDDIIADLKQALD 396
OAH_OAS_sulfhy TIGR01326
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ...
 18-399 8.41e-107

OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]


Pssm-ID: 273555 [Multi-domain]  Cd Length: 418  Bit Score: 322.00  E-value: 8.41e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDG-------INVLRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:TIGR01326   1 HFETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDStehaaalFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIA 170
Cdd:TIGR01326  81 GQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDE-NTKAVFAETIGNPQINVL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVV----------------VADREF 234
Cdd:TIGR01326 160 DIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVdggkfdwnngrfplftTPDPSY 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  235 RGRALAEAVAYQQFAA----------GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDH 304
Cdd:TIGR01326 240 HGLVFTETLGNPAFILkarvqllrdlGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASH 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  305 PGHALAARQMD-GFGGIVSIRLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVRL 380
Cdd:TIGR01326 320 PHHALAKKYLPkGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLkagVTPGLIRL 399

                         410
                  ....*....|....*....
gi 738387631  381 SVGIEDVADLQADLEAGLE 399
Cdd:TIGR01326 400 SVGIENIDDIIADLEQALE 418
PRK08249 PRK08249
cystathionine gamma-synthase family protein;
18-399 1.27e-103

cystathionine gamma-synthase family protein;


Pssm-ID: 236202 [Multi-domain]  Cd Length: 398  Bit Score: 313.22  E-value: 1.27e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVL-------RAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:PRK08249   8 GVGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDEWydvalgkKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFST 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPGRTaLLWVETPSNPLLGIA 170
Cdd:PRK08249  88 GMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCETGDHEQIEAEIAKGCD-LLYLETPTNPTLKIV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGaVVVADREfrgraLAEAVAYQQFAA 250
Cdd:PRK08249 167 DIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGG-VVCGSKE-----LMEQVYHYREIN 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 251 GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEA 330
Cdd:PRK08249 241 GATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFVLKGGMD 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738387631 331 AARAFAEATELFALSVSLGGVESLlcYSSEMTHASVRGTP-----LAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK08249 321 TVKRLLPKLRYAHRAANLGAVETI--YGPARTTSHVENTLeeraaLGIPEGLVRISVGIEDTEDLIADLEQAFA 392
PRK08776 PRK08776
O-succinylhomoserine (thiol)-lyase;
20-399 1.60e-103

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181554 [Multi-domain]  Cd Length: 405  Bit Score: 313.46  E-value: 1.60e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  20 TTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRAgHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALL 99
Cdd:PRK08776  14 ATAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQ-YDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 100 RAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVrPGRTALLWVETPSNPLLGIADLAAWAQIA 179
Cdd:PRK08776  93 NALLQPGDTLVVPHDAYGGSWRLFNALAKKGHFALITADLTDPRSLADAL-AQSPKLVLIETPSNPLLRITDLRFVIEAA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 180 HDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGPQDS 259
Cdd:PRK08776 172 HKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAE-----LHQQLVWWANALGLTGSPFDA 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 260 YLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFAEAT 339
Cdd:PRK08776 247 FLTLRGLRTLDARLRVHQENADAIAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFELEGGEAAVRAFVDGL 326

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738387631 340 ELFALSVSLGGVESLLCYSSEMTHASVrgTPLA-----VPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK08776 327 RYFTLAESLGGVESLIAHPASMTHAAM--TAEAraaagISDGLLRLSVGIESAEDLLIDLRAGLA 389
PLN02509 PLN02509
cystathionine beta-lyase
 20-398 2.88e-102

cystathionine beta-lyase


Pssm-ID: 178125 [Multi-domain]  Cd Length: 464  Bit Score: 311.96  E-value: 2.88e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  20 TTTAVHAGQEPDPLTgAVVPPIYQTSTFVQDGInVLRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALL 99
Cdd:PLN02509  88 STLLVNLDNKFDPFD-AMSTPLYQTATFKQPSA-IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVT 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 100 RaVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWAQIA 179
Cdd:PLN02509 166 H-LIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGP-QTKLVWLESPTNPRQQISDIRKIAEMA 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 180 HDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVadrefRGRALAEAVAYQQFAAGAVAGPQDS 259
Cdd:PLN02509 244 HAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAV-----KGEKLAKEVYFLQNSEGSGLAPFDC 318

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 260 YLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIrLAGGEAAARAFAEAT 339
Cdd:PLN02509 319 WLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETT 397

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738387631 340 ELFALSVSLGGVESLLCYSSEMTHASVrgtPLAV------PTDLVRLSVGIEDVADLQADLEAGL 398
Cdd:PLN02509 398 KYFSIAVSFGSVKSLISMPCFMSHASI---PAEVrearglTEDLVRISAGIEDVDDLISDLDIAF 459
PRK08861 PRK08861
O-succinylhomoserine (thiol)-lyase;
17-395 1.96e-98

O-succinylhomoserine (thiol)-lyase;


Pssm-ID: 181567 [Multi-domain]  Cd Length: 388  Bit Score: 299.89  E-value: 1.96e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  17 RGFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLrAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAED 96
Cdd:PRK08861   4 RKPATIAVRTGIESDSQYHAVVPPIYLSTNYGFPAFGEV-PKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALN 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  97 ALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVrPGRTALLWVETPSNPLLGIADLAAWA 176
Cdd:PRK08861  83 LWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAAL-AKKPKLILLETPSNPLVRVVDIAELC 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 177 QIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREFrgralAEAVAYQQFAAGAVAGP 256
Cdd:PRK08861 162 QKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEH-----AEELAWWGNCIGATGTP 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 257 QDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFA 336
Cdd:PRK08861 237 FDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFEFAGSFEQLKVFV 316

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 738387631 337 EATELFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVRLSVGIEDVADLQADLE 395
Cdd:PRK08861 317 KALALFSLAESLGGVESLICHPASMTHRAMGEEALAeagVSQQLLRLSVGLEDAQDLIADLD 378
PRK08045 PRK08045
cystathionine gamma-synthase; Provisional
 17-399 2.55e-98

cystathionine gamma-synthase; Provisional


Pssm-ID: 169194 [Multi-domain]  Cd Length: 386  Bit Score: 299.50  E-value: 2.55e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  17 RGFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRAgHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAED 96
Cdd:PRK08045   3 RKQATIAVRSGLNDDEQYGCVVPPIHLSSTYNFTGFNEPRA-HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  97 ALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLAAWA 176
Cdd:PRK08045  82 LVTTVFLKPGDLLVAPHDCYGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAE-KPKLVLVESPSNPLLRVVDIAKIC 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 177 QIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGP 256
Cdd:PRK08045 161 HLAREAGAVSVVDNTFLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPD-----VVTELAWWANNIGVTGGA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 257 QDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFA 336
Cdd:PRK08045 236 FDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFELDGDEQTLRRFL 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738387631 337 EATELFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK08045 316 GGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAaagISETLLRISTGIEDGEDLIADLENGFR 381
PRK06767 PRK06767
methionine gamma-lyase; Provisional
 19-399 3.25e-98

methionine gamma-lyase; Provisional


Pssm-ID: 180685 [Multi-domain]  Cd Length: 386  Bit Score: 299.06  E-value: 3.25e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  19 FTTTAVHAGQEPDPLTGAVVPPIYQTSTF----VQDGINVL---RAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASG 91
Cdd:PRK06767   6 METALIHHGYTSEEHKGSLTPPLFQTSTFtfetAQQGEASFagvDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  92 LAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIAD 171
Cdd:PRK06767  86 MAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRP-NTKLIFVETPINPTMKLID 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 172 LAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGaVVVADRefrgRALAEAVAYQQFAAG 251
Cdd:PRK06767 165 LKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAG-VTICKT----RALAEKIRPMRKDIG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 252 AVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYpglpdhPGHALAARQMDGFGGIVSIRLAGGEAA 331
Cdd:PRK06767 240 GIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFSIKGGKEE 313

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738387631 332 ARAFAEATELFALSVSLGGVESLLCYSSEMTHASV---RGTPLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK06767 314 TQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIpaeLRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
PRK08574 PRK08574
cystathionine gamma-synthase family protein;
21-399 9.95e-98

cystathionine gamma-synthase family protein;


Pssm-ID: 236298 [Multi-domain]  Cd Length: 385  Bit Score: 297.75  E-value: 9.95e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  21 TTAVHAGQEPDPLtGAVVPPIYQTSTFVQDGINVLR-AGHE--YSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDA 97
Cdd:PRK08574   5 TDAVRGYRGSDPY-GSLQPPIYLTALFRQEGEAYPSdRGFDlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAIST 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  98 LLRAVLRPGDHIVLGGDGYGGTHRLITTvLEPWGVSntpVDITDPTA--VAAAVRPGRTALLWVETPSNPLLGIADLAAW 175
Cdd:PRK08574  84 LFFSLLKAGDRVVLPMEAYGTTLRLLKS-LEKFGVK---VVLAYPSTedIIEAIKEGRTKLVFIETMTNPTLKVIDVPEV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 176 AQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREF-------RGRalaeavayqqf 248
Cdd:PRK08574 160 AKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFleelwewRRR----------- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 249 aAGAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAAR--QMDGFGGIVSIRLA 326
Cdd:PRK08574 229 -LGTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAKRlfGKDLYGGVVSFRVK 307

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 738387631 327 GGEAAARAFAEATELFALSVSLGGVESLLCY---SSEMTHASVRGTPLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK08574 308 GGRDAVLKFLRSLKLIKPSPSLGGVESLATYpvkSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALG 383
PRK07582 PRK07582
cystathionine gamma-lyase; Validated
 21-398 5.34e-94

cystathionine gamma-lyase; Validated


Pssm-ID: 236061  Cd Length: 366  Bit Score: 287.66  E-value: 5.34e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  21 TTAVHAGQePDPLTGA-VVPPIYQTSTFVQDGiNVLRAGHEYSRGSNPTRNGFETQLAALEhGDRAFAFASGLAAEDALL 99
Cdd:PRK07582   6 TRSVHAGG-PEAVPGEpVLPGPVFAAPYHLSP-GEPTGPDTYGRASNPTWRALEAALGELE-GAEALVFPSGMAAITAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 100 RAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNtpvdITDPTAVAAAVRPGRTALLWVETPSNPLLGIADLAAWAQIA 179
Cdd:PRK07582  83 RALLRPGDTVVVPADGYYQVRALAREYLAPLGVTV----REAPTAGMAEAALAGADLVLAETPSNPGLDVCDLAALAAAA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 180 HDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAGPQDS 259
Cdd:PRK07582 159 HAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPE-----LMAAVERWRLLAGAIPGPFEA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 260 YLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFAEAt 339
Cdd:PRK07582 234 WLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFELADAAAAERFVAAS- 312

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738387631 340 ELFALSVSLGGVesllcyssemtHASV-----RGTPlaVPTDLVRLSVGIEDVADLQADLEAGL 398
Cdd:PRK07582 313 RLVVAATSFGGV-----------HTSAdrrarWGDA--VPEGFVRLSCGIEDTDDLVADLERAL 363
O_suc_HS_sulf TIGR01325
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ...
 21-398 1.34e-93

O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 188131  Cd Length: 381  Bit Score: 287.13  E-value: 1.34e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   21 TTAVHAGQEPDPLtGAVVPPIYQTSTFVQDGINVLRA-------GHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLA 93
Cdd:TIGR01325   2 TLAVRGGMLRSGF-EETAEALYLTSGYVYDSAAVAAKrfagelpGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   94 AEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPGrTALLWVETPSNPLLGIADLA 173
Cdd:TIGR01325  81 AIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPN-TKAVFVETPSNPLQELVDIA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  174 AWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGaVVVADREFrgraLAEAVAYQQFAAGAV 253
Cdd:TIGR01325 160 AVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGG-AILGSEEY----MDEPVQKLLRHTGPA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  254 AGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLaGGEAAAR 333
Cdd:TIGR01325 235 MSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDL-DCRQAAF 313

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738387631  334 AFAEATELFALSVSLGGVESLLCYSSEMTHASV--RGTPLAVPTD-LVRLSVGIEDVADLQADLEAGL 398
Cdd:TIGR01325 314 KVLDAMRLVDISNNLGDAKSTITHPATTTHRRMgpEERAAAGIGDgLVRLSVGLEDVDDLIADIDRAL 381
PRK07812 PRK07812
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 19-398 4.50e-89

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 236105  Cd Length: 436  Bit Score: 277.40  E-value: 4.50e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  19 FTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRA-------GHEYSRGSNPTRNGFETQLAALEHGDRAFAFASG 91
Cdd:PRK07812  14 FETKQIHAGQTPDPATNARALPIYQTTSYTFDDTDHAAAlfglaepGNIYTRIMNPTQDVVEQRIAALEGGVAALLLASG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  92 LAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPV-DITDPTAVAAAVRPgRTALLWVETPSNPLLGIA 170
Cdd:PRK07812  94 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRP-NTKAFFAETISNPQIDVL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVV----------------VADREF 234
Cdd:PRK07812 173 DIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVdggtfdwtqgrfpgftTPDPSY 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 235 RGRALAE--AVAYQQFA-------AGAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHP 305
Cdd:PRK07812 253 HGVVFAElgPPAYALKArvqllrdLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSP 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 306 GHALAARQM-DGFGGIVSIRLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVRLS 381
Cdd:PRK07812 333 WYERAKRLApKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLatgVTPGLVRLA 412

                        410
                 ....*....|....*..
gi 738387631 382 VGIEDVADLQADLEAGL 398
Cdd:PRK07812 413 VGIEGIDDILADLEAGF 429
PRK08134 PRK08134
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 18-398 4.89e-88

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 236159  Cd Length: 433  Bit Score: 274.31  E-value: 4.89e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFV-QDG------INVLRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:PRK08134   8 GFDTLALHAGAAPDPATGARAVPIHLTTSFVfRDSdhaaalFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIA 170
Cdd:PRK08134  88 GQAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRP-NTRLLFGETLGNPGLEVL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADR-----------------E 233
Cdd:PRK08134 167 DIPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRfdweasgkfpeltepyaG 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 234 FRGRALAEAVAYQQFAA----------GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPD 303
Cdd:PRK08134 247 FHGMVFAEESTVAAFLLrarreglrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELES 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 304 HPGHALAARQM-DGFGGIVSIRLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVR 379
Cdd:PRK08134 327 HPDHALAKRLLpRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAaagIGEGTIR 406

                        410
                 ....*....|....*....
gi 738387631 380 LSVGIEDVADLQADLEAGL 398
Cdd:PRK08134 407 LSIGLEDADDLIDDLKRAL 425
PRK05994 PRK05994
O-acetylhomoserine aminocarboxypropyltransferase; Validated
 18-399 9.27e-88

O-acetylhomoserine aminocarboxypropyltransferase; Validated


Pssm-ID: 180344 [Multi-domain]  Cd Length: 427  Bit Score: 273.51  E-value: 9.27e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGIN------VLRA-GHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:PRK05994   7 GFATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADhaaslfGLQAfGNIYTRITNPTNAVLEERVAALEGGTAALAVAS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIA 170
Cdd:PRK05994  87 GHAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITP-RTKAIFIESIANPGGTVT 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADR-----------------E 233
Cdd:PRK05994 166 DIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTfdwsksgkypmlseprpE 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 234 FRGRALAEAVAYQQFAAGA-VAG---------PQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPD 303
Cdd:PRK05994 246 YHGLVLHETFGNFAFAIAArVLGlrdlgpaisPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPD 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 304 HPGHALAARQM-DGFGGIVSIRLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPL----AVPtDLV 378
Cdd:PRK05994 326 DPYHALAQKYSpKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKvaagAGP-DVV 404

                        410       420
                 ....*....|....*....|.
gi 738387631 379 RLSVGIEDVADLQADLEAGLE 399
Cdd:PRK05994 405 RLSIGIEDVDDIIADLEQALA 425
PRK06460 PRK06460
hypothetical protein; Provisional
 31-398 4.80e-87

hypothetical protein; Provisional


Pssm-ID: 235807 [Multi-domain]  Cd Length: 376  Bit Score: 270.16  E-value: 4.80e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  31 DPLTGAVVPPIYQTSTFVQDGINVLRagheYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLRAVLRPGDHIV 110
Cdd:PRK06460  13 DEATGAITTPIYQTTAYHYPEGEKYR----YSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTALALLKPGNSVL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 111 LGGDGYGGTHRLITTVLEPWGVSntpVDITDP--TAVAAAVRPGRTALLWVETPSNPLLGIADLAAWAQIAHDAGALLVV 188
Cdd:PRK06460  89 VHRDMFGRSYRFFTDYLKNWGVN---VDASNPgsDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 189 DNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGaVVVADREfrgraLAEAVAYQQFAAGAVAGPQDSYLAARGLKT 268
Cdd:PRK06460 166 DATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAG-LAAGYGK-----LLNVIDQMRRTLGTSLDPHAAYLTLRGIKT 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 269 LGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFAEATELFALSVSL 348
Cdd:PRK06460 240 LKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTL 319

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 738387631 349 GGVESLLCYSSEMTHASVrgTP-----LAVPTDLVRLSVGIEDVADLQADLEAGL 398
Cdd:PRK06460 320 GGVNSVISHPATMSHRTL--SLeerkiVGITDSLLRLSVGIEDVNDLIEDLDRAL 372
PRK06434 PRK06434
cystathionine gamma-lyase; Validated
 17-398 3.07e-82

cystathionine gamma-lyase; Validated


Pssm-ID: 102374 [Multi-domain]  Cd Length: 384  Bit Score: 257.91  E-value: 3.07e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  17 RGFTTTAVHAGQEPDPLTGAVVPPIYQTSTFV-----QDGI--NVLRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFA 89
Cdd:PRK06434   7 NGFNTRAVQSGELRDPRFGNVTTPIFETSTFVypnseKEAYmdSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  90 SGLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSntpVDITDPTAV-AAAVRPGRTALLWVETPSNPLLG 168
Cdd:PRK06434  87 SGMGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIH---VDYIDTDRLnSLDFDPSNYDLIYAESITNPTLK 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 169 IADLAAWAQIAHdaGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREFRGRALAEAVAYqqf 248
Cdd:PRK06434 164 VPDIKNVSSFCH--ENDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTL--- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 249 aaGAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLpdhpghALAARQMDGFGGIVSIRLAGG 328
Cdd:PRK06434 239 --GSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVYYPDT------EIGKKVLRGFGGMLSFELRSM 310

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738387631 329 EAAARAFAEAtELFALSVSLGGVESLLCYSSEMTHASVrgTP-----LAVPTDLVRLSVGIEDVADLQADLEAGL 398
Cdd:PRK06434 311 EDVHKFIRNL-EIPMVAASLGGVESLITLPVETSHSSL--SPeererLGISDNLVRFSIGIEDIDDLIKDIENAL 382
PRK07269 PRK07269
cystathionine gamma-synthase; Reviewed
 21-399 3.40e-79

cystathionine gamma-synthase; Reviewed


Pssm-ID: 235983  Cd Length: 364  Bit Score: 249.35  E-value: 3.40e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  21 TTAVHAGQEPDPLTGAVVPPI-----YQTSTFVQDginvlrAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAE 95
Cdd:PRK07269   9 TILAQAGIKSDEATGALVTPLhfsttYQHPEFGQS------TGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  96 dALLRAVLRPGDHIVLGGDGYGGTHRLITTVlEPWGVSNTPVDITDPTAVAAAVRpgRTALLWVETPSNPLLGIADLAAW 175
Cdd:PRK07269  83 -VLAFSVFPVGSKVVAVRDLYGGSFRWFNQQ-EKEGRFHFTYANTEEELIAAIEE--DTDIVYIETPTNPLMVEFDIEKV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 176 AQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREfrgraLAEAVAYQQFAAGAVAG 255
Cdd:PRK07269 159 AKLAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLE-----LYEKLFYNLNTTGAVLS 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 256 PQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLpdhpghalaarqmdgfGGIVSIRLAGGEAAARAF 335
Cdd:PRK07269 234 PFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------------GGMISFKVADETRIPHIL 297

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 336 AEAtELFALSVSLGGVESLLCYSSEMTHASVrgtPLAV------PTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK07269 298 NSL-KVFTFAESLGGVESLITYPTTQTHADI---PAEVrhsyglTDDLLRLSIGIEDARDLIADLKQALE 363
PRK05939 PRK05939
cystathionine gamma-synthase family protein;
35-399 3.98e-78

cystathionine gamma-synthase family protein;


Pssm-ID: 235650 [Multi-domain]  Cd Length: 397  Bit Score: 247.68  E-value: 3.98e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  35 GAVVPPIYQTSTF----VQDGINVL---RAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLRAVLRPGD 107
Cdd:PRK05939   8 GAVHKPIHTSVTYgyedARDLIDVFqgkKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGD 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 108 HIVLGGDGYGGTHRLITTVLEpWGVSNTPVDITDPTAVAAAVRPGrTALLWVETPSNPLLGIADLAAWAQIAHDAGALLV 187
Cdd:PRK05939  88 HLVSSQFLFGNTNSLFGTLRG-LGVEVTMVDATDVQNVAAAIRPN-TRMVFVETIANPGTQVADLAGIGALCRERGLLYV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 188 VDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVV------------VADrEFRgRALAEAVAYQQFAA----- 250
Cdd:PRK05939 166 VDNTMTSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTdtglfdwsaypnIFP-AYR-KGDPQQWGLTQIRKkglrd 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 251 -GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGE 329
Cdd:PRK05939 244 mGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGI 323

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738387631 330 AAARAFAEAtELFALSVSLGGVESLLCYSS-----EMThASVRGTpLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK05939 324 DCFDFLNRL-KLVIKATHLGDTRTLVIPVAptiyyEMG-AERRAS-MGIADSLIRVSVGIEDEADLIADFEQALD 395
PRK06084 PRK06084
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
21-399 7.48e-78

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;


Pssm-ID: 180392 [Multi-domain]  Cd Length: 425  Bit Score: 247.89  E-value: 7.48e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  21 TTAVHAGQEPDPLTGAVVPPIYQTSTFV----QDGINVLR---AGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLA 93
Cdd:PRK06084   5 TLAIHAGYSPDPTTKAVAVPIYQTTSYAfddtQHGADLFDlkvPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGMA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  94 AEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIADLA 173
Cdd:PRK06084  85 AITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDE-RTKAVFCESIGNPAGNIIDIQ 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 174 AWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVV------------------VADREFR 235
Cdd:PRK06084 164 ALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVdsgkfpwaehkerfallnTPDPSYH 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 236 GRALAEAVAYQQFAA----------GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHP 305
Cdd:PRK06084 244 GVTYTEAFGPAAFIGrcrvvplrnmGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHP 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 306 GHALAARQMDGF-GGIVSIRLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPTDLVRLS 381
Cdd:PRK06084 324 EHELARRYMGGKpASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEkagVSRDMVRLS 403

                        410
                 ....*....|....*...
gi 738387631 382 VGIEDVADLQADLEAGLE 399
Cdd:PRK06084 404 IGIEHIDDIIADLAQALD 421
PRK08248 PRK08248
homocysteine synthase;
21-399 1.13e-76

homocysteine synthase;


Pssm-ID: 236201 [Multi-domain]  Cd Length: 431  Bit Score: 245.14  E-value: 1.13e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  21 TTAVHAGQEPDPLTGAVVPPIYQTSTFV----QDGINVL---RAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFASGLA 93
Cdd:PRK08248  11 TLAIHAGQEIDPTTGSRAVPIYQTTSYGfrdsEHAANLFslkEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAVSSGQA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  94 AEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRpGRTALLWVETPSNPLLGIADLA 173
Cdd:PRK08248  91 AITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAIT-DKTKALFAETIGNPKGDVLDIE 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 174 AWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVV-----------------VADREFRG 236
Cdd:PRK08248 170 AVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVdsgkfdwkgsgkfpgltEPDPSYHG 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 237 RALAEAVAYQQFAA----------GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPG 306
Cdd:PRK08248 250 LVYTDAVGEAAYITkarvqllrdlGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGLPSHPS 329

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 307 HALAARQM-DGFGGIVSIRLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGT---PLAVPTDLVRLSV 382
Cdd:PRK08248 330 YELAKKYLpKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEeqlAAGVTPGLVRLSV 409

                        410
                 ....*....|....*..
gi 738387631 383 GIEDVADLQADLEAGLE 399
Cdd:PRK08248 410 GTEAIDDILDDLRQAIR 426
PRK05968 PRK05968
hypothetical protein; Provisional
 26-399 5.08e-75

hypothetical protein; Provisional


Pssm-ID: 168320 [Multi-domain]  Cd Length: 389  Bit Score: 239.60  E-value: 5.08e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  26 AGQEPDPLtGAVVPPIYQTSTFVQDGINVLRAGHE-------YSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDAL 98
Cdd:PRK05968  16 AHDEGNAF-DAVVPPIFQTSLFTFDSYDEMEDVYAgekvrpiYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAISST 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  99 LRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVrPGrTALLWVETPSNPLLGIADLAAWAQI 178
Cdd:PRK05968  95 VLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PG-AKLLYLESPTSWVFELQDVAALAAL 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 179 AHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGaVVVADREFRGRALAEAVAYqqfaAGAVAGPQD 258
Cdd:PRK05968 173 AKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAG-VVAGSKEHIARINAEAYPY----LGAKLSPFE 247

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 259 SYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAarqmdGFGGIVSIRLAGGEAAARAFAEA 338
Cdd:PRK05968 248 AWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGLS-----GTSGLFSFIFREGIDVRAFADAL 322

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738387631 339 TeLFALSVSLGGVESL-------LCYSSEMTHASVRGtplaVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK05968 323 K-LFRLGVSWGGHESLvvpaevvLQQKAQPNSAARFG----VSPRSVRLHVGLEGTEALWADLEQALA 385
PRK07049 PRK07049
cystathionine gamma-synthase family protein;
27-399 5.15e-75

cystathionine gamma-synthase family protein;


Pssm-ID: 180809 [Multi-domain]  Cd Length: 427  Bit Score: 240.73  E-value: 5.15e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  27 GQEPDPLTGAVVPPIYQTSTFVQ----------DGINVLR-------AGHEYSRGSNPTRNGFETQLAALEHGDRAFAFA 89
Cdd:PRK07049  26 GYDPELSEGAVKPPVFLTSTFVFrsaedgrdffDYVSGRKeppagegAGLVYSRFNHPNSEIVEDRLAVYEGAESAALFS 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  90 SGLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSntPVDITD-------PTAVAAAVRPGRTALLWVETP 162
Cdd:PRK07049 106 SGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVG--AVGFADglseaaiGAAAEAAAAKGRVSLILIETP 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 163 SNPLLGIADLAAWAQIAHDAGA------LLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVAdrefrg 236
Cdd:PRK07049 184 ANPTNSLVDVAAVRRVADAIEArqghrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAGAVLGR------ 257

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 237 RALAEAVAYQQFAAGAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGL--PDHPGHALAARQM 314
Cdd:PRK07049 258 KALIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGAVYKRQC 337

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 315 DGFGGIVSIRLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASV---RGTPLAVPTDLVRLSVGIEDVADLQ 391
Cdd:PRK07049 338 TGAGSTFSFDIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVpadVRERIGVLESTIRLSIGIEHPDDLI 417


                 ....*...
gi 738387631 392 ADLEAGLE 399
Cdd:PRK07049 418 ADLAQALD 425
PRK07504 PRK07504
O-succinylhomoserine sulfhydrylase; Reviewed
 13-399 1.17e-72

O-succinylhomoserine sulfhydrylase; Reviewed


Pssm-ID: 168979 [Multi-domain]  Cd Length: 398  Bit Score: 233.49  E-value: 1.17e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  13 RPAVRgftttAVHAGQEPDPLtGAVVPPIYQTSTFVQDGINVLRA-------GHEYSRGSNPTRNGFETQLAALEHGDRA 85
Cdd:PRK07504  10 RPATR-----LVHSGTLRSQF-GETSEALFLTQGFVYDTAEAAEArfkgedpGFIYSRYSNPTVDMFEKRMCALEGAEDA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  86 FAFASGLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNP 165
Cdd:PRK07504  84 RATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRP-NTKVFFLESPTNP 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 166 LLGIADLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGaVVVADREFrgraLAEAVAY 245
Cdd:PRK07504 163 TLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGG-VVLSDKAW----IEEHLQD 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 246 QQFAAGAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRL 325
Cdd:PRK07504 238 YFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFEL 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738387631 326 AGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRG---TPLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK07504 318 KGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPearAELGISEGFLRLSAGLEDTDDLIEDLAAALK 394
cysta_beta_ly_B TIGR01324
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ...
 21-399 6.35e-71

cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 130391 [Multi-domain]  Cd Length: 377  Bit Score: 228.61  E-value: 6.35e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   21 TTAVHAGQEPDPLTGAVVPPIYQTSTFVQDG-INVLRAGHEYSRGSN--PTRNGFETQLAALEHGDRAFAFASGLAAEDA 97
Cdd:TIGR01324   1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDShAAQRRAKGELTYGRRgtLTHFALQDAMCELEGGAGCYLYPSGLAAVTN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   98 LLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPGrTALLWVETPSNPLLGIADLAAWAQ 177
Cdd:TIGR01324  81 SILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYDPLIGEDIATLIQPN-TKVLFLEAPSSITFEIQDIPAIAK 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  178 IAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREFrgralaEAVAYQQFAAGAVAGPQ 257
Cdd:TIGR01324 160 AARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANARTW------DQLREHSYLMGQMVDAD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  258 DSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAF-A 336
Cdd:TIGR01324 234 DAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHEFWKRDFSGSSGLFSFVLQRLTQKQVHAfL 313

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 738387631  337 EATELFALSVSLGGVESL-LCYSSEMTHASVRGTPLAVPtdLVRLSVGIEDVADLQADLEAGLE 399
Cdd:TIGR01324 314 DHLQLFGLGYSWGGYESLaLCNQPELGHRPNIKRNLEGP--LIRVHIGLENVDDLKADLKAGFE 375
PRK05967 PRK05967
cystathionine beta-lyase; Provisional
 18-398 4.22e-67

cystathionine beta-lyase; Provisional


Pssm-ID: 235657 [Multi-domain]  Cd Length: 395  Bit Score: 218.91  E-value: 4.22e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFV-QDGINVLRAGHEYSRGS--NPTRNGFETQLAALEHGDRAFAFASGLAA 94
Cdd:PRK05967  12 GINTRLAHDGNDPGDYHGFVNPPVVHASTVLfPDAETMATRGQKYTYGTrgTPTTDALCKAIDALEGSAGTILVPSGLAA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  95 EDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSntpVDITDP---TAVAAAVRPGrTALLWVETPSNPLLGIAD 171
Cdd:PRK05967  92 VTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVE---VEYYDPeigAGIAKLMRPN-TKVVHTEAPGSNTFEMQD 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 172 LAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGavVVADREFRGRALAEAVAyqqfAAG 251
Cdd:PRK05967 168 IPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLG--TVSANEKCWPQLLEAHG----TLG 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 252 AVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAA 331
Cdd:PRK05967 242 LCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGPEK 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 738387631 332 ARAFAE----ATELFALSVSLGGVESLLCYSSeMTHASVRGTPLAVPtdLVRLSVGIEDVADLQADLEAGL 398
Cdd:PRK05967 322 GKAKAHafldALEIFGLGYSWGGYESLALHVK-LGDRTVAKAPYAGP--VIRLQIGLEDVPDLKADLERGF 389
PRK07810 PRK07810
O-succinylhomoserine sulfhydrylase; Provisional
 40-398 1.22e-65

O-succinylhomoserine sulfhydrylase; Provisional


Pssm-ID: 236103 [Multi-domain]  Cd Length: 403  Bit Score: 215.37  E-value: 1.22e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  40 PIYQTSTFVQDGINVLRAGHE-------YSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLRAVLRPGDHIVLG 112
Cdd:PRK07810  36 ALYLTSGYVYESAAAAEAAFTgeldrfvYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVFTALGALLGAGDRLVAA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 113 GDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPGRTALLWvETPSNPLLGIADLAAWAQIAHDAGALLVVDNTF 192
Cdd:PRK07810 116 RSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFF-ETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVF 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 193 ASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAvVVADREF-RGRAlaeavayQQFA--AGAVAGPQDSYLAARGLKTL 269
Cdd:PRK07810 195 ATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGA-ILGDREYiDGPV-------QKLMrhTGPALSAFNAWVLLKGLETL 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 270 GLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAARAFA----EATELFALS 345
Cdd:PRK07810 267 ALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFELDAPEDAAKKRAfevlDKLRVIDIS 346

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 738387631 346 VSLGGVESLLCYSSEMTHASV--RGTPLAVPTD-LVRLSVGIEDVADLQADLEAGL 398
Cdd:PRK07810 347 NNLGDAKSLITHPATTTHRAMgpEGRAAIGLGDgVVRLSVGLEDTDDLIADLDRAL 402
PRK05613 PRK05613
O-acetylhomoserine/O-acetylserine sulfhydrylase;
18-399 3.32e-65

O-acetylhomoserine/O-acetylserine sulfhydrylase;


Pssm-ID: 168128 [Multi-domain]  Cd Length: 437  Bit Score: 215.51  E-value: 3.32e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDG-------INVLRAGHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:PRK05613  13 GFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSaehakqrFALEDLGPIYSRLTNPTVEALENRIASLEGGVHAVAFAS 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPV-DITDPTAVAAAVRPGrTALLWVETPSNPLLGI 169
Cdd:PRK05613  93 GQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPN-TKAFFGETFANPQADV 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 170 ADLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAV---------------------V 228
Cdd:PRK05613 172 LDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLidggkfdwtverdgkpvfpyfV 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 229 VADREFRGRALAE--AVAYQQFA-------AGAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYP 299
Cdd:PRK05613 252 TPDPAYHGLKYADlgAPAFGLKAragllrdTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFA 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 300 GLPDHPGHALAAR-QMDGFGGIVSIRLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLA---VPT 375
Cdd:PRK05613 332 GLKDSPWYATKEKlGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLAragITQ 411

                        410       420
                 ....*....|....*....|....
gi 738387631 376 DLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK05613 412 ATVRLSVGIEDIDDIIADLEGGFA 435
PRK07050 PRK07050
cystathionine beta-lyase; Provisional
 17-399 3.40e-64

cystathionine beta-lyase; Provisional


Pssm-ID: 180810 [Multi-domain]  Cd Length: 394  Bit Score: 211.51  E-value: 3.40e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  17 RGFTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVLRA-------GHEYSRGSNPTRNGFETQLAALEHGDRAFAFA 89
Cdd:PRK07050   8 RALQTRIVQPDDQIPPGFRSFVTPVARASTVVFPDLATMRAldwrqdvQWRYGLHATPTSLALAQRLAEIEGGRHALLQP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  90 SGLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGI 169
Cdd:PRK07050  88 SGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQP-NTRLIWLEAPGSVTMEV 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 170 ADLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREFRGRALAeavAYQQFA 249
Cdd:PRK07050 167 PDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKL---ARMRLG 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 250 AGAvaGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGE 329
Cdd:PRK07050 244 IGV--SADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDERY 321

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 738387631 330 AAARAFA--EATELFALSVSLGGVESL-LCYSSemthASVRGTPLAVPTDLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK07050 322 SPAQVDAfvEALELFAIGWSWGGACSLaMPYDV----ASMRTAKWPHRGTLVRLYIGLEDEADLIADLEQALE 390
PLN02242 PLN02242
methionine gamma-lyase
 61-384 3.14e-62

methionine gamma-lyase


Pssm-ID: 215134  Cd Length: 418  Bit Score: 206.93  E-value: 3.14e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  61 YSRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVL-EPWGVSNTPVDI 139
Cdd:PLN02242  70 YSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASNTLYGGTHALLAHFLpRKCNITTTFVDI 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 140 TDPTAVAAAVRPGRTALLWVETPSNPLLGIADLAAWAQIAHDAGALLVVDNTFAsPYLQRPLDLGADVVVHSTTKYIGGH 219
Cdd:PLN02242 150 TDLEAVKKAVVPGKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNTFA-PMVLSPARLGADVVVHSISKFISGG 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 220 SDVLGGAV------VVADREFRGRALaeavayqqFAAGAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPev 293
Cdd:PLN02242 229 ADIIAGAVcgpaelVNSMMDLHHGAL--------MLLGPTMNPKVAFELSERLPHLSLRMKEHCRRAMEYAKRMKELG-- 298

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 294 AQVFYPGLPDHPGHALAARQMD---GFGGIVSIRLAGGEAAARAFAE---ATELFALSVSLGGVESLLCYSSEMTHASVR 367
Cdd:PLN02242 299 LKVIYPGLEDHPQHALLKSMANkgyGFGGLLCLDMDTEERANRLMRYlqnSTQFGFMAVSLGYYETLMSCSGSSTSSELD 378

                        330       340
                 ....*....|....*....|
gi 738387631 368 GTPLA---VPTDLVRLSVGI 384
Cdd:PLN02242 379 PEEKAaagISPGLVRMSVGY 398
PRK09028 PRK09028
cystathionine beta-lyase; Provisional
 21-399 1.87e-59

cystathionine beta-lyase; Provisional


Pssm-ID: 181615 [Multi-domain]  Cd Length: 394  Bit Score: 199.19  E-value: 1.87e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  21 TTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGINVL------RAGHE--YSRGSNPTRNGFETQLAALEHGDRAFAFASGL 92
Cdd:PRK09028   7 TKIVSAGRDKKWTKGVINPPVFRASTVVFDTVAEMrhaaknRANGEmfYGRRGTPTHFAFQAAIVELEGGAGTALYPSGA 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  93 AAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPGrTALLWVETPSNPLLGIADL 172
Cdd:PRK09028  87 AAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYDPMIGEGIRELIRPN-TKVLFLESPGSITMEVQDV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 173 AAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREFrgralaEAVAYQQFAAGA 252
Cdd:PRK09028 166 PTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKHW------DQLREHSYLMGQ 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 253 VAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLAGGEAAA 332
Cdd:PRK09028 240 CTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVLKQGDPKA 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738387631 333 RAF-AEATELFALSVSLGGVESLLCYSSEMTHASVRGTPLAVPTdLVRLSVGIEDVADLQADLEAGLE 399
Cdd:PRK09028 320 VTAlVEGMQHFKMGFSWGGFESLILGVFGINKLRTATNWDFSKP-LIRLHIGLEDVDDLIADLEAGFE 386
PRK08114 PRK08114
cystathionine beta-lyase; Provisional
 19-399 5.38e-52

cystathionine beta-lyase; Provisional


Pssm-ID: 181231 [Multi-domain]  Cd Length: 395  Bit Score: 179.51  E-value: 5.38e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  19 FTTTAVHAGQEPDPLTGAVVPPIYQTSTFVQDGI------NVLRAGHE--YSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:PRK08114   6 LDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDSVeakkhaTRNRANGElfYGRRGTLTHFSLQEAMCELEGGAGCALYPC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPgRTALLWVETPSNPLLGIA 170
Cdd:PRK08114  86 GAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWFDPLIGADIAKLIQP-NTKVVFLESPGSITMEVH 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DL----AAWAQIAHDAgaLLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAVVVADREFrgralaEAVAYQ 246
Cdd:PRK08114 165 DVpaivAAVRSVNPDA--VIMIDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARCW------EQLREN 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 247 QFAAGAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDHPGHALAARQMDGFGGIVSIRLA 326
Cdd:PRK08114 237 SYLMGQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFVLK 316

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 327 GGEAAARAFAEAT--ELFALSVSLGGVESLLCYSSEMTHASVR--------GTplavptdLVRLSVGIEDVADLQADLEA 396
Cdd:PRK08114 317 KKLTDEQLANYLDnfSLFSMAYSWGGFESLILANQPEEIAAIRpagevdftGT-------LIRLHIGLEDVDDLIADLAA 389


                 ...
gi 738387631 397 GLE 399
Cdd:PRK08114 390 GFA 392
PRK06702 PRK06702
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
18-398 5.01e-48

bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;


Pssm-ID: 102505 [Multi-domain]  Cd Length: 432  Bit Score: 169.85  E-value: 5.01e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  18 GFTTTAVHAGQEPDPLTGAVVPpIYQTSTFVQDGINVLRA-------GHEYSRGSNPTRNGFETQLAALEHGDRAFAFAS 90
Cdd:PRK06702   6 GKGTICVQGGYTPKNGEPRVLP-LYQSTTYKYDTSDDLAAlfnleaeGYIYTRIGNPTLAAFEQKLAELEGGVGAVATAS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  91 GLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDITDPTAVAAAVRPGRTALLWVETPSNPLLGIA 170
Cdd:PRK06702  85 GQAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNLTADEIVALANDKTKLVYAESLGNPAMNVL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 171 DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGADVVVHSTTKYIGGHSDVLGGAV----------------VVADREF 234
Cdd:PRK06702 165 NFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVidggnfdwtngkypelVEPDPSY 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 235 RGRALAE---AVAYQQFAA-------GAVAGPQDSYLAARGLKTLGLRMDRHGANAAALADWLQGRPEVAQVFYPGLPDH 304
Cdd:PRK06702 245 HGVSYVQnfgAAAYIVKARvqllrdyGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSN 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 305 PGHALAARQMD-GFGGIVSIRLAGGEAAARAFAEATELFALSVSLGGVESLLCYSSEMTHASVRGTP---LAVPTDLVRL 380
Cdd:PRK06702 325 ENYSLAQKYLKkGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDqrlAGVTSDLIRL 404

                        410
                 ....*....|....*...
gi 738387631 381 SVGIEDVADLQADLEAGL 398
Cdd:PRK06702 405 SVGIEDVSDIIADLEAAL 422
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 72-218 9.33e-13

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 66.25  E-value: 9.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  72 FETQLAALEHG--DRAFAFASGLAAEDALLRAVLRPGDHIVLGGDGYGGTHRLITTVLEPwGVSNTPVD-----ITDPTA 144
Cdd:cd01494    5 LEEKLARLLQPgnDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVAAELAGA-KPVPVPVDdagygGLDVAI 83

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 738387631 145 VAAAVRPGRTALLWVETPSNPLLGIADLAAWAQIAHDAGALLVVDNTFASPY----LQRPLDLGADVVVHSTTKYIGG 218
Cdd:cd01494   84 LEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLHKNLGG 161
PRK06225 PRK06225
pyridoxal phosphate-dependent aminotransferase;
82-244 5.76e-06

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235749 [Multi-domain]  Cd Length: 380  Bit Score: 48.21  E-value: 5.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  82 GDRAFAFASGLAAEDALLRAVLRPGDHIVLGGDGYggthRLITTVLEPWGVSNTPVDITD--------PTAVAAAVrPGR 153
Cdd:PRK06225  83 DDEALITAGATESLYLVMRAFLSPGDNAVTPDPGY----LIIDNFASRFGAEVIEVPIYSeecnykltPELVKENM-DEN 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 154 TALLWVETPSNPlLGIA----DLAAWAQIAHDAGALLVVDNTFASPYLQRPLDLGAD----VVVHSTTKyIGGHSDVLGG 225
Cdd:PRK06225 158 TRLIYLIDPLNP-LGSSyteeEIKEFAEIARDNDAFLLHDCTYRDFAREHTLAAEYApehtVTSYSFSK-IFGMAGLRIG 235

                        170
                 ....*....|....*....
gi 738387631 226 AVVVAdrefrgRALAEAVA 244
Cdd:PRK06225 236 AVVAT------PDLIEVVK 248
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 96-321 1.03e-05

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 47.34  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  96 DALLRAVLRPGDHIVLGGDGYGGtHRLITTVLE------PWGVSNTpvDITDPTAVAAAVRPgRTALLWVETPSNP---L 166
Cdd:cd00609   73 SLLLRALLNPGDEVLVPDPTYPG-YEAAARLAGaevvpvPLDEEGG--FLLDLELLEAAKTP-KTKLLYLNNPNNPtgaV 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 167 LGIADLAAWAQIAHDAGALLVVDNTFA------SPYLQRPLDLGADVVVhsttkYIGGHSDVLG------GAVVVADREF 234
Cdd:cd00609  149 LSEEELEELAELAKKHGILIISDEAYAelvydgEPPPALALLDAYERVI-----VLRSFSKTFGlpglriGYLIAPPEEL 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 235 RGRALAEAVAY--------QQFAAGAVAGPQDSYLAARglktlglrmDRHGANAAALADWLQGRPEVAQV-------FYP 299
Cdd:cd00609  224 LERLKKLLPYTtsgpstlsQAAAAAALDDGEEHLEELR---------ERYRRRRDALLEALKELGPLVVVkpsggffLWL 294

                        250       260
                 ....*....|....*....|..
gi 738387631 300 GLPDHPGHALAARQMDGFGGIV 321
Cdd:cd00609  295 DLPEGDDEEFLERLLLEAGVVV 316
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
 97-190 1.45e-05

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 47.05  E-value: 1.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  97 ALLRAVLRPGDHIVLGGDGY----------GGTHRLITTVLEP-WGVsntpvditDPTAVAAAVRPgRTALLWVETPSNP 165
Cdd:COG0436  105 LALLALLNPGDEVLVPDPGYpsyraavrlaGGKPVPVPLDEENgFLP--------DPEALEAAITP-RTKAIVLNSPNNP 175

                         90       100
                 ....*....|....*....|....*...
gi 738387631 166 ---LLGIADLAAWAQIAHDAGALLVVDN 190
Cdd:COG0436  176 tgaVYSREELEALAELAREHDLLVISDE 203
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
58-287 1.80e-05

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 46.05  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   58 GHEySRGSNPTRNGFETQLAALEHGDRAFAFASGLAAEDALLRAVLRPGDHIVLGGDGY-----GGTHRLITtvlepwGV 132
Cdd:pfam01212  24 GDE-VYGGDPTVNRLEDRVAELFGKEAALFVPSGTAANQLALMAHCQRGDEVICGEPAHihfdeTGGHAELG------GV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  133 SNTPVDIT-----DPTAVAAAVRPG------RTALLWVETPSNPLLG----IADLAAWAQIAHDAGALLVVD------NT 191
Cdd:pfam01212  97 QPRPLDGDeagnmDLEDLEAAIREVgadifpPTGLISLENTHNSAGGqvvsLENLREIAALAREHGIPVHLDgarfanAA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  192 FASPYLQRPLDLGADVVVHSTTKyiGGHSDVlgGAVVVADREFrgraLAEAVAYQQFAAGAVAgpQDSYLAARGLKTLGL 271
Cdd:pfam01212 177 VALGVIVKEITSYADSVTMCLSK--GLGAPV--GSVLAGSDDF----IAKAIRQRKYLGGGLR--QAGVLAAAGLRALEE 246

                         250
                  ....*....|....*....
gi 738387631  272 ---RMDRHGANAAALADWL 287
Cdd:pfam01212 247 gvaRLARDHATARRLAEGL 265
PRK00451 PRK00451
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
138-209 1.98e-05

aminomethyl-transferring glycine dehydrogenase subunit GcvPA;


Pssm-ID: 234769 [Multi-domain]  Cd Length: 447  Bit Score: 46.67  E-value: 1.98e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 738387631 138 DITDPTAVAAAVrPGRTALLWVETPSnpLLG-IADLAAWAQIAHDAGALLVVdntFASP----YLQRPLDLGADVVV 209
Cdd:PRK00451 190 GVTDLEALEAAV-DDDTAAVVVQYPN--FFGvIEDLEEIAEIAHAGGALFIV---GVDPvslgLLKPPGEYGADIVV 260
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
 99-290 3.01e-05

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 45.70  E-value: 3.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   99 LRAVLRPGDHIVLGGDGYGGthrlittVLEPW-------GVSNTPVDIT-----DPTAVAAAVRPgRTALLWVETPSNPL 166
Cdd:pfam00266  81 LGRSLKPGDEIVITEMEHHA-------NLVPWqelakrtGARVRVLPLDedgllDLDELEKLITP-KTKLVAITHVSNVT 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  167 LGIADLAAWAQIAHDAGALLVVDntFASPYLQRPLD---LGADVVVHSTTKYIG--------GHSDVL-------GGAVV 228
Cdd:pfam00266 153 GTIQPVPEIGKLAHQYGALVLVD--AAQAIGHRPIDvqkLGVDFLAFSGHKLYGptgigvlyGRRDLLekmppllGGGGM 230

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738387631  229 VADREFRGRALAEavAYQQFAAG--AVAGPQDSYLAARGLKTLGL-RMDRHganAAALADWLQGR 290
Cdd:pfam00266 231 IETVSLQESTFAD--APWKFEAGtpNIAGIIGLGAALEYLSEIGLeAIEKH---EHELAQYLYER 290
SufS_like cd06453
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ...
 104-218 1.27e-04

Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.


Pssm-ID: 99746 [Multi-domain]  Cd Length: 373  Bit Score: 43.99  E-value: 1.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 104 RPGDHIVlggdgyggthrliTTVLE------PW-------GVSNTPVDIT-----DPTAVAAAVRPgRTALLWVETPSNP 165
Cdd:cd06453   86 KPGDEIV-------------TSVMEhhsnivPWqqlaertGAKLKVVPVDddgqlDLEALEKLLTE-RTKLVAVTHVSNV 151

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 738387631 166 LLGIADLAAWAQIAHDAGALLVVDNTFASPYLqrPLD---LGADVVVHSTTKYIGG 218
Cdd:cd06453  152 LGTINPVKEIGEIAHEAGVPVLVDGAQSAGHM--PVDvqdLGCDFLAFSGHKMLGP 205
DegT_DnrJ_EryC1 pfam01041
DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all ...
 47-308 1.99e-04

DegT/DnrJ/EryC1/StrS aminotransferase family; The members of this family are probably all pyridoxal-phosphate-dependent aminotransferase enzymes with a variety of molecular functions. The family includes StsA, StsC and StsS. The aminotransferase activity was demonstrated for purified StsC protein as the L-glutamine:scyllo-inosose aminotransferase EC:2.6.1.50, which catalyzes the first amino transfer in the biosynthesis of the streptidine subunit of streptomycin.


Pssm-ID: 395827  Cd Length: 360  Bit Score: 43.43  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   47 FVQDGINVLRAGhEYSRGsnPTRNGFETQLAALEHGDRAFAFASGLAAEDALLRAV-LRPGDHIVLGGDGYGGT-HRLIT 124
Cdd:pfam01041   7 ELAAVREVLKSG-WLTTG--PYVREFERAFAAYLGVKHAIAVSSGTAALHLALRALgVGPGDEVITPSFTFVATaNAALR 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  125 TVLEPWgvsntPVDI------TDPTAVAAAVRPGRTALLWVETPSNPllgiADLAAWAQIAHDAGALLVVD--NTFASPY 196
Cdd:pfam01041  84 LGAKPV-----FVDIdpdtynIDPEAIEAAITPRTKAIIPVHLYGQP----ADMDAIRAIAARHGLPVIEDaaHALGATY 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  197 LQRPLDLGADVVVHS--TTKYIG-GHsdvlGGAVVVADREfrgraLAE-AVAYQQFAAGAVAGPQ------------DSY 260
Cdd:pfam01041 155 QGKKVGTLGDAATFSfhPTKNLTtGE----GGAVVTNDPE-----LAEkARVLRNHGMVRKADKRywhevlgynyrmTEI 225

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 738387631  261 LAARG---LKTLGLRMDRHGANAAALADWLQGRPEVAQVfyPGLPDHPGHA 308
Cdd:pfam01041 226 QAAIGlaqLERLDEFIARRREIAALYQTLLADLPGFTPL--TTPPEADVHA 274
PLN02855 PLN02855
Bifunctional selenocysteine lyase/cysteine desulfurase
 100-231 4.05e-04

Bifunctional selenocysteine lyase/cysteine desulfurase


Pssm-ID: 215460 [Multi-domain]  Cd Length: 424  Bit Score: 42.43  E-value: 4.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 100 RAVLRPGDHIVLggdgyggthrlitTVLE------PWG------------VSNTPVDITDPTAVAAAVRPgRTALLWVET 161
Cdd:PLN02855 116 LANLKPGDEVIL-------------SVAEhhsnivPWQlvaqktgavlkfVGLTPDEVLDVEQLKELLSE-KTKLVATHH 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 162 PSNPLLGIADLAAWAQIAHDAGALLVVDNTFASPYLqrPLD---LGADVVVHSTTKYIG--------GHSDVL------- 223
Cdd:PLN02855 182 VSNVLGSILPVEDIVHWAHAVGAKVLVDACQSVPHM--PVDvqtLGADFLVASSHKMCGptgigflwGKSDLLesmppfl 259


                 ....*...
gi 738387631 224 GGAVVVAD 231
Cdd:PLN02855 260 GGGEMISD 267
GDC-P cd00613
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ...
 89-214 5.67e-04

Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.


Pssm-ID: 99737 [Multi-domain]  Cd Length: 398  Bit Score: 41.83  E-value: 5.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  89 ASGLAAEDALLRAVLR--PGDHIVLGGDGYGGTHRLITTVLEPWGVSNTPVDIT-----DPTAVAAAVRPgRTALLWVET 161
Cdd:cd00613   89 EATAAAEAAGLAAIRAyhKRNKVLVPDSAHPTNPAVARTRGEPLGIEVVEVPSDeggtvDLEALKEEVSE-EVAALMVQY 167

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 738387631 162 PSNplLGI--ADLAAWAQIAHDAGALLVVD-NTFASPYLQRPLDLGADVVVHSTTK 214
Cdd:cd00613  168 PNT--LGVfeDLIKEIADIAHSAGALVYVDgDNLNLTGLKPPGEYGADIVVGNLQK 221
GcvP1 COG0403
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ...
 140-209 1.03e-03

Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440172 [Multi-domain]  Cd Length: 442  Bit Score: 41.17  E-value: 1.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 738387631 140 TDPTAVAAAVrPGRTALLWVETPSnpLLG-IADLAAWAQIAHDAGALLVVdntFASPY----LQRPLDLGADVVV 209
Cdd:COG0403  193 TDLEALKALL-DDDVAGVLVQYPN--FFGvIEDLRAIAEAAHAAGALVIV---AADPLslglLKPPGELGADIVV 261
GDC-P pfam02347
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ...
 93-215 2.19e-03

Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2


Pssm-ID: 396772 [Multi-domain]  Cd Length: 428  Bit Score: 40.05  E-value: 2.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631   93 AAEDALL--RAVLRPGDHIVLGGDGYGGTHRLITTVLEPWG-----VSNTPVDITDPTAVAAAVrpgrtallwVETPsNP 165
Cdd:pfam02347 139 AAEAMALaaRASKKKGKKFVVDKDVHPQTLEVLKTRAKPFGieiveVDYTEEGVTDLKDVFGVL---------VQYP-NT 208

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 738387631  166 LLGIADLAAWAQIAHDAGALLVV-DNTFASPYLQRPLDLGADVVVHSTTKY 215
Cdd:pfam02347 209 DGRIEDYKELIELAHQRKSLVVVaADLLALTLLKPPGEFGADIAVGSAQRF 259
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 54-110 4.47e-03

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 39.08  E-value: 4.47e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  54 VLRAGHE----YSRGSNPTRN---------GFETQLAALEHGDRAFAFASGLAAEDALLRAVLRPGDHIV 110
Cdd:cd06454   20 VIEAAKEaldkYGVGAGGSRLisgtsdlheELEEELAEFHGKEAALVFSSGYAANDGVLSTLAGKGDLII 89
AGAT_like cd06451
Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate ...
 83-238 6.32e-03

Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-glyoxylate aminotransferase (SGAT), and 3-hydroxykynurenine transaminase (HKT). AGAT is a homodimeric protein, which catalyses the transamination of glyoxylate to glycine, and SGAT converts serine and glyoxylate to hydroxypyruvate and glycine. HKT catalyzes the PLP-dependent transamination of 3-hydroxykynurenine, a potentially toxic metabolite of the kynurenine pathway.


Pssm-ID: 99744 [Multi-domain]  Cd Length: 356  Bit Score: 38.43  E-value: 6.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  83 DRAFAFA-SGLAAEDALLRAVLRPGDHIVLGGDGYGGtHRLIT----------TVLEPWGVSNTPVDITDptaVAAAVRP 151
Cdd:cd06451   50 GLTFLLSgSGTGAMEAALSNLLEPGDKVLVGVNGVFG-DRWADmaerygadvdVVEKPWGEAVSPEEIAE---ALEQHDI 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 152 GRTALLWVETPS---NPLLGIAdlaawaQIAHDAGALLVVD--NTFASPYLqRPLDLGADVVVHSTTKYIGGHSdvlGGA 226
Cdd:cd06451  126 KAVTLTHNETSTgvlNPLEGIG------ALAKKHDALLIVDavSSLGGEPF-RMDEWGVDVAYTGSQKALGAPP---GLG 195

                        170
                 ....*....|..
gi 738387631 227 VVVADREFRGRA 238
Cdd:cd06451  196 PIAFSERALERI 207
YnbB COG4100
Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion ...
 88-251 6.81e-03

Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 443276  Cd Length: 409  Bit Score: 38.55  E-value: 6.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631  88 FASGLAAEDALLR---------------AVLRPGDHI-------------VLGGDGYG-GThrlittvLEPWGVSNTPVD 138
Cdd:COG4100   66 YADVFGAEDALVRpqivsgthaialalfGVLRPGDELlsitgkpydtleeVIGIRGEGqGS-------LKEFGISYRQVP 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 738387631 139 IT-----DPTAVAAAVRPgRTALL---------WvetpsNPLLGIADLAAWAQIAHDA--GALLVVDN---TFASPylQR 199
Cdd:COG4100  139 LTedgkiDLEAIKKAINE-KTKMVliqrsrgysW-----RPSLTIEEIGEIIKFVKSInpDVICFVDNcygEFVET--RE 210

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 738387631 200 PLDLGADVVVHSTTKYIGGHSDVLGGAVVvadrefrGRA-LAEAVAYQQFAAG 251
Cdd:COG4100  211 PTEVGADLMAGSLIKNPGGGLAPTGGYIA-------GRKdLVELAAYRLTAPG 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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