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Conserved domains on  [gi|736877152|ref|WP_034876786|]
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LytTR family DNA-binding domain-containing protein [Bifidobacterium moukalabense]

Protein Classification

LytR/AlgR family response regulator transcription factor( domain architecture ID 11461715)

LytR/AlgR family response regulator transcription factor with a signal receiver (REC) and a DNA-binding domain may be part of a two-component regulatory system

CATH:  3.40.50.2300|2.40.50.1020
Gene Ontology:  GO:0000160|GO:0000156|GO:0003677
PubMed:  11557134|27013338|18462668|31100988|20226724|16740923|12034833
SCOP:  4003632|4004734

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-244 2.71e-40

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


:

Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 139.18  E-value: 2.71e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKTMCTAYfrekRGLDIdCATFAGTDDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARF 80
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKY----PDLEV-VGEASNGEEALELLEEHKPDLVFLDIQMPG-------LDGFELARQ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152  81 LRKQRDDCPIVFITSSSDFAVLGYEVQAIGYLLKPVGRADFDMTMDRVCETLSKRPRVTHLSADKPTratdaawqvaFgn 160
Cdd:COG3279   69 LRELDPPPPIIFTTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKDR----------I-- 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152 161 pAVNMDRRL-------IAYCLSSAHYVEFTFADGTCSkIRTNFSDVEQRLTvFDNFYRTARGVLVNFDYVAGIS---NAE 230
Cdd:COG3279  137 -FVKSGGKLvkiplddILYIEAEGNYVKIHTKDKKYL-VRKTLKELEEKLP-PKQFFRVHRSYIVNLDKIKEIEknfNGE 213

                        250
                 ....*....|....
gi 736877152 231 FVMKGGKHIPITKT 244
Cdd:COG3279  214 VVLKNGEEIPVSRR 227
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-244 2.71e-40

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 139.18  E-value: 2.71e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKTMCTAYfrekRGLDIdCATFAGTDDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARF 80
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKY----PDLEV-VGEASNGEEALELLEEHKPDLVFLDIQMPG-------LDGFELARQ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152  81 LRKQRDDCPIVFITSSSDFAVLGYEVQAIGYLLKPVGRADFDMTMDRVCETLSKRPRVTHLSADKPTratdaawqvaFgn 160
Cdd:COG3279   69 LRELDPPPPIIFTTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKDR----------I-- 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152 161 pAVNMDRRL-------IAYCLSSAHYVEFTFADGTCSkIRTNFSDVEQRLTvFDNFYRTARGVLVNFDYVAGIS---NAE 230
Cdd:COG3279  137 -FVKSGGKLvkiplddILYIEAEGNYVKIHTKDKKYL-VRKTLKELEEKLP-PKQFFRVHRSYIVNLDKIKEIEknfNGE 213

                        250
                 ....*....|....
gi 736877152 231 FVMKGGKHIPITKT 244
Cdd:COG3279  214 VVLKNGEEIPVSRR 227
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-120 3.33e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 74.88  E-value: 3.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152    4 VAIVEDHPAERQLMKTMCtayfrEKRGLDIdcATFAGTDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARFLRK 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL-----EKEGYVV--AEADDGKEALELLKEERPDLILLDINMPGM-------DGLELLKRIRR 66

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 736877152   84 QRDDCPIVFITSSSD--FAVLGYEVQAIGYLLKPVGRAD 120
Cdd:pfam00072  67 RDPTTPVIILTAHGDedDAVEALEAGADDFLSKPFDPDE 105
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 6-115 5.31e-16

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 71.49  E-value: 5.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   6 IVEDHPAERQLMKTMCtayfrEKRGLDIDCATFAgtDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARFLRKQR 85
Cdd:cd00156    2 IVDDDPAIRELLKSLL-----EREGYEVDTAADG--EEALELLREERPDLVLLDLMMPGM-------DGLELLRKLRELP 67

                         90       100       110
                 ....*....|....*....|....*....|..
gi 736877152  86 DDCPIVFITSSSDF--AVLGYEVQAIGYLLKP 115
Cdd:cd00156   68 PDIPVIVLTAKADEedAVRALELGADDYLVKP 99
PRK14084 PRK14084
DNA-binding response regulator;
2-151 1.92e-08

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 53.60  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   2 MRVAIVEDHPAERQLMKTMCTayfrEKRGLD-IDCATfaGTDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARF 80
Cdd:PRK14084   1 MKALIVDDEPLARNELTYLLN----EIGGFEeINEAE--NVKETLEALLINQYDIIFLDINLMDE-------SGIELAAK 67

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736877152  81 LRKQRDDCPIVFITSSSDFAVLGYEVQAIGYLLKPVGRADFDMTMDRVCETLSKRPRVTHLSADKPTRATD 151
Cdd:PRK14084  68 IQKMKEPPAIIFATAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRATKAKDDNNASAIANDMSANFD 138
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 170-244 5.30e-08

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 49.50  E-value: 5.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   170 IAYCLSSAHYVEFTFADGTCsKIRTNFSDVEQRLtVFDNFYRTARGVLVNFDYVAGI-----SNAEFVMKGGKHIPITKT 244
Cdd:smart00850  11 ILYIEAEGNYVTVHTKDGTY-LVRGTLKELEERL-DPDNFFRIHRSYIVNLDHIKEIepwfnGTYLLILKNGEEVPVSRR 88
 
Name Accession Description Interval E-value
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-244 2.71e-40

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 139.18  E-value: 2.71e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKTMCTAYfrekRGLDIdCATFAGTDDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARF 80
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKY----PDLEV-VGEASNGEEALELLEEHKPDLVFLDIQMPG-------LDGFELARQ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152  81 LRKQRDDCPIVFITSSSDFAVLGYEVQAIGYLLKPVGRADFDMTMDRVCETLSKRPRVTHLSADKPTratdaawqvaFgn 160
Cdd:COG3279   69 LRELDPPPPIIFTTAYDEYALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKDR----------I-- 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152 161 pAVNMDRRL-------IAYCLSSAHYVEFTFADGTCSkIRTNFSDVEQRLTvFDNFYRTARGVLVNFDYVAGIS---NAE 230
Cdd:COG3279  137 -FVKSGGKLvkiplddILYIEAEGNYVKIHTKDKKYL-VRKTLKELEEKLP-PKQFFRVHRSYIVNLDKIKEIEknfNGE 213

                        250
                 ....*....|....
gi 736877152 231 FVMKGGKHIPITKT 244
Cdd:COG3279  214 VVLKNGEEIPVSRR 227
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-130 3.17e-18

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 78.47  E-value: 3.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKTMCtayfrEKRGLDIDCATFAGTDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARF 80
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYL-----ERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDG-------DGLELLRE 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 736877152  81 LRKQRDDCPIVFITSSSDFAVLGYEVQ--AIGYLLKPVGRADFDMTMDRVCE 130
Cdd:COG4565   71 LRARGPDVDVIVITAARDPETVREALRagVVDYLIKPFTFERLREALERYLE 122
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-120 3.33e-17

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 74.88  E-value: 3.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152    4 VAIVEDHPAERQLMKTMCtayfrEKRGLDIdcATFAGTDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARFLRK 83
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL-----EKEGYVV--AEADDGKEALELLKEERPDLILLDINMPGM-------DGLELLKRIRR 66

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 736877152   84 QRDDCPIVFITSSSD--FAVLGYEVQAIGYLLKPVGRAD 120
Cdd:pfam00072  67 RDPTTPVIILTAHGDedDAVEALEAGADDFLSKPFDPDE 105
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 6-115 5.31e-16

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 71.49  E-value: 5.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   6 IVEDHPAERQLMKTMCtayfrEKRGLDIDCATFAgtDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARFLRKQR 85
Cdd:cd00156    2 IVDDDPAIRELLKSLL-----EREGYEVDTAADG--EEALELLREERPDLVLLDLMMPGM-------DGLELLRKLRELP 67

                         90       100       110
                 ....*....|....*....|....*....|..
gi 736877152  86 DDCPIVFITSSSDF--AVLGYEVQAIGYLLKP 115
Cdd:cd00156   68 PDIPVIVLTAKADEedAVRALELGADDYLVKP 99
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 2-123 4.79e-15

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 69.96  E-value: 4.79e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   2 MRVAIVEDHPAERQLMKTMCTAYFREKrGLDIDCATFAGTDDFIESWKSGRFDlvllDCYLTDDETDETTPTGLDIARFL 81
Cdd:cd17533    1 MNIFILEDDKIQRVRLEEIIENILKIE-NIEYVIELTGKTEELLEKIKERGKN----GIYFLDIDIKMEEKNGLEVAQKI 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 736877152  82 RKQRDDCPIVFITSSSDFAVLGYEVQ--AIGYLLKPVGRADFDM 123
Cdd:cd17533   76 RKYDPYAIIIFVTTHSEFAPLTFEYKvaALDFILKPLKLEEFKK 119
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-144 1.76e-13

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 67.29  E-value: 1.76e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKtmctAYFrEKRGLDIDCATFAgtDDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARF 80
Cdd:COG0745    1 MPRILVVEDDPDIRELLA----DAL-EREGYEVDTAADG--EEALELLEEERPDLILLDLMLPG-------MDGLEVCRR 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736877152  81 LRKQRDDCPIVFITSSSDFA--VLGYEVQAIGYLLKPVGRADFdmtMDRVcETLSKRPRVTHLSAD 144
Cdd:COG0745   67 LRARPSDIPIIMLTARDDEEdrVRGLEAGADDYLTKPFDPEEL---LARI-RALLRRRAAEVLRVG 128
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-128 2.06e-13

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 65.26  E-value: 2.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKTMCtayfrEKRGLDIDCATfaGTDDFIESWKSGRFDLVLLDCYLtddetdettP--TGLDIA 78
Cdd:COG0784    5 GKRILVVDDNPDNRELLRRLL-----ERLGYEVTTAE--DGAEALELLRAGPPDLILLDINM---------PgmDGLELL 68

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 736877152  79 RFLRK--QRDDCPIVFITSSSDFAVL--GYEVQAIGYLLKPVGRADFDMTMDRV 128
Cdd:COG0784   69 RRIRAlpRLPDIPIIALTAYADEEDRerALEAGADDYLTKPVDPEELLEALRRL 122
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-129 6.23e-13

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 65.32  E-value: 6.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKTMCtayfrEKRGLDIDCATfagtD--DFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIA 78
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLL-----EAAGYEVVEAA----DgeEALELLQEHRPDLILLDLEMPD-------MDGLELC 64

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 736877152  79 RFLRKQRD--DCPIVFITSSSDFA--VLGYEVQAIGYLLKPVGRADFDMTMDRVC 129
Cdd:COG3706   65 RRLRADPRtaDIPIIFLTALDDEEdrARALEAGADDYLTKPFDPEELLARVDLVA 119
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-142 1.94e-12

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 66.53  E-value: 1.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKTMCtayfrEKRGLDIDCATFAgtDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARF 80
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELL-----ERAGYEVETAASG--EEALALLREEPPDLVLLDLRMPGM-------DGLELLRE 67

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 736877152  81 LRKQRDDCPIVFIT--SSSDFAVLGYEVQAIGYLLKPVGRADFDMTMDRVCETLSKRPRVTHLS 142
Cdd:COG2204   68 LRALDPDLPVILLTgyGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENAEDS 131
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-135 3.51e-12

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 64.03  E-value: 3.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKTMCtayfrekRGLDIDCATFAGTDDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARF 80
Cdd:COG3437    6 APTVLIVDDDPENLELLRQLL-------RTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPG-------MDGFELLRL 71

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 736877152  81 LRKQRD--DCPIVFITSSSDFAVL--GYEVQAIGYLLKPVGRADFdmtMDRVCETLSKR 135
Cdd:COG3437   72 LRADPStrDIPVIFLTALADPEDRerALEAGADDYLTKPFDPEEL---LARVRNALELR 127
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
 2-126 1.80e-11

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 59.73  E-value: 1.80e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   2 MRVAIVEDHPAERQLMKTMCtayfrEKRGLDIdCATFAGTDDFIESWKSGRFDLVLLDCYLtDDETDettptGLDIARFL 81
Cdd:cd17534    1 KKILIVEDEAIIALDLKEIL-----ESLGYEV-VGIADSGEEAIELAEENKPDLILMDINL-KGDMD-----GIEAAREI 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 736877152  82 RKQRDdCPIVFITSSSDFAVLGY--EVQAIGYLLKPVGRADFDMTMD 126
Cdd:cd17534   69 REKFD-IPVIFLTAYSDEETLERakETNPYGYLVKPFNERELKAAIE 114
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
 6-133 1.84e-11

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 59.86  E-value: 1.84e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   6 IVEDHPAERQLMktmctAYFREKRGlDID-CATFAGTDDFIESWKSGRFDLVLLDCYLTDDEtdettptGLDIARFLRKQ 84
Cdd:cd17532    3 IVDDEPLAREEL-----RYLLEEHP-DIEiVGEAENGEEALEAIEELKPDVVFLDIQMPGLD-------GLELAKKLSKL 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 736877152  85 RDDCPIVFITSSSDFAVLGYEVQAIGYLLKPVGRADFDMTMDRVCETLS 133
Cdd:cd17532   70 AKPPLIVFVTAYDEYAVEAFELNAVDYLLKPFSEERLAEALAKLRKRLS 118
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 6-115 1.40e-09

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 53.95  E-value: 1.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   6 IVEDHPAERQLMKtmctaYFREKRGLDIDCATFAgtDDFIESWKSGRFDLVLLDCYLTD-DetdettptGLDIARFLRKQ 84
Cdd:cd17574    2 VVEDDEEIAELLS-----DYLEKEGYEVDTAADG--EEALELAREEQPDLIILDVMLPGmD--------GFEVCRRLREK 66

                         90       100       110
                 ....*....|....*....|....*....|...
gi 736877152  85 RDDCPIVFITSSSDFA--VLGYEVQAIGYLLKP 115
Cdd:cd17574   67 GSDIPIIMLTAKDEEEdkVLGLELGADDYITKP 99
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 3-127 2.18e-09

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 54.17  E-value: 2.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   3 RVAIVEDHPAERQLMKtmctAYFREKRGLDI--DCATFAGTDDFIeswKSGRFDLVLLDCYLTDDetdettpTGLDIARF 80
Cdd:cd19925    2 NVLIVEDDPMVAEIHR----AYVEQVPGFTVigTAGTGEEALKLL---KERQPDLILLDIYLPDG-------NGLDLLRE 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 736877152  81 LRKQRDDCPIVFITSSSDFAVLGYEVQ--AIGYLLKPVGRADFDMTMDR 127
Cdd:cd19925   68 LRAAGHDVDVIVVTAANDVETVREALRlgVVDYLIKPFTFERLRQRLER 116
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-115 2.63e-09

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 53.24  E-value: 2.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   3 RVAIVEDHPAERQLMKTMctayFREKRGLDIdCATFAGTDDFIESWKSGRFDLVLLDCYLtddetdettP--TGLDIARF 80
Cdd:COG4753    1 KVLIVDDEPLIREGLKRI----LEWEAGFEV-VGEAENGEEALELLEEHKPDLVITDINM---------PgmDGLELLEA 66

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 736877152  81 LRKQRDDCPIVFITSSSDF--AVLGYEVQAIGYLLKP 115
Cdd:COG4753   67 IRELDPDTKIIILSGYSDFeyAQEAIKLGADDYLLKP 103
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 6-132 1.77e-08

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 51.57  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   6 IVEDHPAERQLMKTMctayfREKRGLDID-CATFA-GTD--DFIESWKsgrFDLVLldcyltddeTDETTP--TGLDIAR 79
Cdd:cd17536    3 IVDDEPLIREGLKKL-----IDWEELGFEvVGEAEnGEEalELIEEHK---PDIVI---------TDIRMPgmDGLELIE 65

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 736877152  80 FLRKQRDDCPIVFITSSSDFAvlgYEVQAI-----GYLLKPVGRADFDMTMDRVCETL 132
Cdd:cd17536   66 KIRELYPDIKIIILSGYDDFE---YAQKAIrlgvvDYLLKPVDEEELEEALEKAKEEL 120
PRK14084 PRK14084
DNA-binding response regulator;
2-151 1.92e-08

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 53.60  E-value: 1.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   2 MRVAIVEDHPAERQLMKTMCTayfrEKRGLD-IDCATfaGTDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARF 80
Cdd:PRK14084   1 MKALIVDDEPLARNELTYLLN----EIGGFEeINEAE--NVKETLEALLINQYDIIFLDINLMDE-------SGIELAAK 67

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736877152  81 LRKQRDDCPIVFITSSSDFAVLGYEVQAIGYLLKPVGRADFDMTMDRVCETLSKRPRVTHLSADKPTRATD 151
Cdd:PRK14084  68 IQKMKEPPAIIFATAHDQFAVKAFELNATDYILKPFEQKRIEQAVNKVRATKAKDDNNASAIANDMSANFD 138
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 3-115 2.07e-08

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 51.23  E-value: 2.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   3 RVAIVEDHPAERQLMKtmctAYFrEKRGLDIDCATFAGtdDFIESWKSGRFDLVLLDCYLTDDEtdettptGLDIARFLR 82
Cdd:cd17619    2 HILIVEDEPVTRATLK----SYF-EQEGYDVSEAGDGE--EMRQILARQDIDLVLLDINLPGKD-------GLSLTRELR 67

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 736877152  83 kQRDDCPIVFITSSSDFA--VLGYEVQAIGYLLKP 115
Cdd:cd17619   68 -EQSEVGIILVTGRDDEVdrIVGLEIGADDYVTKP 101
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 4-116 2.11e-08

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 50.93  E-value: 2.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   4 VAIVEDHPAERQLMKTMCtayfrEKRGLDIDCATfAGTDDfIESWKSGRFDLVLLDCYLtddetdettP--TGLDIARFL 81
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLL-----EKLGYEVDVAE-NGQEA-LELLKEEPFDLVLMDLQM---------PvmDGLEATRRI 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 736877152  82 RKQ---RDDCPIVFITSSSDFAVLGYEVQA--IGYLLKPV 116
Cdd:cd17546   65 RELeggGRRTPIIALTANALEEDREKCLEAgmDDYLSKPV 104
LytTR smart00850
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 170-244 5.30e-08

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 197918 [Multi-domain]  Cd Length: 96  Bit Score: 49.50  E-value: 5.30e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   170 IAYCLSSAHYVEFTFADGTCsKIRTNFSDVEQRLtVFDNFYRTARGVLVNFDYVAGI-----SNAEFVMKGGKHIPITKT 244
Cdd:smart00850  11 ILYIEAEGNYVTVHTKDGTY-LVRGTLKELEERL-DPDNFFRIHRSYIVNLDHIKEIepwfnGTYLLILKNGEEVPVSRR 88
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 3-120 7.31e-08

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 51.07  E-value: 7.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   3 RVAIVEDHPAERQLMKtmctayfR--EKRGLDIDCAtfAGTDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARF 80
Cdd:COG4567    6 SLLLVDDDEAFARVLA-------RalERRGFEVTTA--ASVEEALALLEQAPPDYAVLDLRLGDG-------SGLDLIEA 69

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 736877152  81 LRKQRDDCPIVFITsssDFAVLGYEVQAIG-----YLLKPVGRAD 120
Cdd:COG4567   70 LRERDPDARIVVLT---GYASIATAVEAIKlgaddYLAKPADADD 111
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 4-121 1.06e-07

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 49.43  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   4 VAIVEDHPAERQLMKTMCTAYFrekrGLDIdCATFAGTDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARFLRK 83
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLESEP----DIEV-VGEAADGEEALALLRELRPDVVLMDLSMPGM-------DGIEALRRLRR 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 736877152  84 QRDDCPIVFITSSSD----FAVLgyEVQAIGYLLKPVGRADF 121
Cdd:cd17535   69 RYPDLKVIVLTAHDDpeyvLRAL--KAGAAGYLLKDSSPEEL 108
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
 2-62 4.25e-07

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 46.02  E-value: 4.25e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736877152     2 MRVAIVEDHPAERQLMKTMCtayfrEKRGLDIDCATFAgtDDFIESWKSGRFDLVLLDCYL 62
Cdd:smart00448   1 MRILVVDDDPLLRELLKALL-----EKEGYEVDEATDG--EEALELLKEEKPDLILLDIMM 54
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-134 4.73e-07

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 47.58  E-value: 4.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   4 VAIVEDHPAERQLMKtmctAYFREKrGLDID-CATfaGTD--DFIESWKsgrFDLVLLDCYLTDdetdettPTGLDIARF 80
Cdd:cd17572    1 VLLVEDSPSLAALYQ----EYLSDE-GYKVThVET--GKEalAFLSDQP---PDVVLLDLKLPD-------MSGMEILKW 63

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 736877152  81 LRKQRDDCPIVFITS--SSDFAVLGYEVQAIGYLLKPvgradFDmtMDRVCETLSK 134
Cdd:cd17572   64 IQERSLPTSVIVITAhgSVDIAVEAMRLGAYDFLEKP-----FD--ADRLRVTVRN 112
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 6-115 1.77e-06

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 45.73  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   6 IVEDHPAERQLMKtmctaYFREKRGLDIDcaTFAGTDDFIESWKSGRFDLVLLDCYLTddETDettptGLDIARFLRKQR 85
Cdd:cd19937    2 VVDDEEDIVELLK-----YNLEKEGYEVV--TAYDGEEALKRAKDEKPDLIILDLMLP--GID-----GLEVCRILRSDP 67

                         90       100       110
                 ....*....|....*....|....*....|....
gi 736877152  86 D--DCPIVFITSSSDFA--VLGYEVQAIGYLLKP 115
Cdd:cd19937   68 KtsSIPIIMLTAKGEEFdkVLGLELGADDYITKP 101
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-143 4.14e-06

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 46.10  E-value: 4.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKTMCTAYfrekrGLDIdCATFAGTDDFIESWKSGRFDLVLLDCYLTDDEtdettptGLDIARF 80
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREA-----GYEV-VAEAADGEDAVELVRELKPDLVIVDIDMPDRD-------GLEAARQ 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 736877152  81 LRKQRdDCPIVFITSSSDFAVLGY--EVQAIGYLLKPVGRADF----DMTMDRVCETLSKRPRVTHLSA 143
Cdd:COG3707   70 ISEER-PAPVILLTAYSDPELIERalEAGVSAYLVKPLDPEDLlpalELALARFRELRALRRELAKLRE 137
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 4-132 4.95e-06

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 45.86  E-value: 4.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   4 VAIVEDHPAERQLMKTMCtayfrekRGLDIDCATFAGTDDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARFLRK 83
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLL-------ESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPG-------MSGLELQEELAA 67

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 736877152  84 QRDDCPIVFITSSSD--FAV----LGyevqAIGYLLKPVGRADFdmtMDRVCETL 132
Cdd:COG4566   68 RGSPLPVIFLTGHGDvpMAVramkAG----AVDFLEKPFDDQAL---LDAVRRAL 115
LytTR pfam04397
LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional ...
 170-248 7.66e-06

LytTr DNA-binding domain; This domain is found in a variety of bacterial transcriptional regulators. The domain binds to a specific DNA sequence pattern.


Pssm-ID: 427920 [Multi-domain]  Cd Length: 98  Bit Score: 43.73  E-value: 7.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152  170 IAYCLSSAHYVEFTFADGTCsKIRTNFSDVEQRLTVfDNFYRTARGVLVNFDYVAGI-----SNAEFVMKGGKHIPITKT 244
Cdd:pfam04397  11 ILYIEAEDKYVTIHTANGEY-LTRGTLKELEEKLPP-DGFFRCHRSYLVNLNKIKEIdpdfnGTYELTLKNGEKIPVSRR 88


                  ....
gi 736877152  245 AVTA 248
Cdd:pfam04397  89 YLKE 92
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 4-121 8.31e-06

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 43.97  E-value: 8.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   4 VAIVEDHPAERQLMktmcTAYFREkRGLDIDCAtfAGTDDFIESWKSGRFDLVLLDCYLTDDEtdettptGLDIARFLRK 83
Cdd:cd17594    2 VLVVDDDAAMRHLL----ILYLRE-RGFDVTAA--ADGAEEARLMLHRRVDLVLLDLRLGQES-------GLDLLRTIRA 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 736877152  84 qRDDCPIVFITSSSDFA---VLGYEVQAIGYLLKPVGRADF 121
Cdd:cd17594   68 -RSDVPIIIISGDRRDEidrVVGLELGADDYLAKPFGLREL 107
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 2-116 9.21e-06

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 43.59  E-value: 9.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   2 MRVAIVEDHPAERQ-LMKTMctayfrEKRGldIDCATFAGTDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARF 80
Cdd:cd17563    1 KSLLLVDDDEVFAErLARAL------ERRG--FEVETAHSVEEALALAREEKPDYAVLDLRLGGD-------SGLDLIPP 65

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 736877152  81 LRKQRDDCPIVFITsssdfavlGY-----EVQAI-----GYLLKPV 116
Cdd:cd17563   66 LRALQPDARIVVLT--------GYasiatAVEAIklgadDYLAKPA 103
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-115 1.20e-05

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 45.34  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAerqLMKTMctAYFREKRGLDIDCATFAGtdDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARF 80
Cdd:PRK11083   3 QPTILLVEDEQA---IADTL--VYALQSEGFTVEWFERGL--PALDKLRQQPPDLVILDVGLPD-------ISGFELCRQ 68

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 736877152  81 LRKQRDDCPIVFITSSSDFA--VLGYEVQAIGYLLKP 115
Cdd:PRK11083  69 LLAFHPALPVIFLTARSDEVdrLVGLEIGADDYVAKP 105
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-81 2.81e-05

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 42.57  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   1 MMRVAIVEDHPAERQLMKTMctayFREKRGLDIdCATFAGTDDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARF 80
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRAL----LEAEPDIEV-VGEAADGEEALELLEELRPDVVLLDIRMPG-------MDGLEALRR 68


                 .
gi 736877152  81 L 81
Cdd:COG2197   69 L 69
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 6-115 4.24e-05

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 41.82  E-value: 4.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   6 IVEDhpaERQLMKTMCTAYfrEKRGLDIDCAtFAGtDDFIESWKSGRFDLVLLDCYLtddetdettP--TGLDIARFLRK 83
Cdd:cd17625    2 VVED---EKDLSEAITKHL--KKEGYTVDVC-FDG-EEGLEYALSGIYDLIILDIML---------PgmDGLEVLKSLRE 65

                         90       100       110
                 ....*....|....*....|....*....|....
gi 736877152  84 QRDDCPIVFITSSSDFA--VLGYEVQAIGYLLKP 115
Cdd:cd17625   66 EGIETPVLLLTALDAVEdrVKGLDLGADDYLPKP 99
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 6-124 4.26e-05

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 41.70  E-value: 4.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   6 IVEDHPaerQLMKTMCTAYfrEKRGLDIDCATFAGtdDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARFLRKQR 85
Cdd:cd17624    3 LVEDDA---LLGDGLKTGL--RKAGYAVDWVRTGA--EAEAALASGPYDLVILDLGLPDG-------DGLDLLRRWRRQG 68

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 736877152  86 DDCPIVFITSSSDFA--VLGYEVQAIGYLLKPvgradFDMT 124
Cdd:cd17624   69 QSLPVLILTARDGVDdrVAGLDAGADDYLVKP-----FALE 104
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 4-118 5.44e-05

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 41.63  E-value: 5.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   4 VAIVEDHPAERQLMKTMCTAyfrekRGLDIDCATFAgtDDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARFLRK 83
Cdd:cd17616    1 VLLIEDDSATAQSIELMLKS-----EGFNVYTTDLG--EEGLDLGKLYDYDIILLDLNLPD-------MSGYEVLRTLRL 66

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 736877152  84 QRDDCPIVFITSSSDF--AVLGYEVQAIGYLLKPVGR 118
Cdd:cd17616   67 AKVKTPILILSGLADIedKVKGLGFGADDYMTKPFHK 103
PRK11697 PRK11697
two-component system response regulator BtsR;
90-241 9.91e-05

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 42.53  E-value: 9.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152  90 IVFITSSSDFAVLGYEVQAIGYLLKPVGRADFDMTMDRVCETLSKRPRVTHLSADK----PTRATDAAWQVAFGNpavnm 165
Cdd:PRK11697  77 IVFVTAFDEYAIKAFEEHAFDYLLKPIDPARLAKTLARLRQERSPQDVLLPEAQPPlkhiPCTGHNRIKLLPLEE----- 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152 166 drrlIAYCLSSAHYVEFTFADGTCS---KIRTnfsdVEQRLTVFdnfyRTARGVLVNFDYVAGI-----SNAEFVMKGGK 237
Cdd:PRK11697 152 ----VEFVSSRLSGVHVVSAEGKGFtelTLKT----LEEKTPLL----RCHRQYLVNPAAIQEIrlldnGQAEIITRSGH 219


                 ....
gi 736877152 238 HIPI 241
Cdd:PRK11697 220 TVPV 223
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 3-116 1.07e-04

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 40.82  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   3 RVAIVEDhpaERQLMKTmcTAYFREKRGLDidCATFAGTDDFIESWKSGRFDLVLLDCYLTDDEtdettptGLDIARFLR 82
Cdd:cd19939    1 RILIVED---ELELARL--TRDYLIKAGLE--VSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMD-------GLTVCREVR 66

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 736877152  83 kQRDDCPIVFITSSSDFA--VLGYEVQAIGYLLKPV 116
Cdd:cd19939   67 -EHSHVPILMLTARTEEMdrVLGLEMGADDYLCKPF 101
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
21-163 1.18e-04

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 43.10  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152  21 CTAYFREKRGLDIDCATFAGTDDFIESWKSGRFDLVLLDCYLTddETDettptGLDIARFLRKQRDDCPIVFIT--SSSD 98
Cdd:PRK10365  18 CTILQALLRGWGYNVALANSGRQALEQVREQVFDLVLCDVRMA--EMD-----GIATLKEIKALNPAIPVLIMTaySSVE 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 736877152  99 FAVLGYEVQAIGYLLKPVgraDFDmtmdRVCETLSKRPRVTHLSADKPTRATDAAWQVAFGNPAV 163
Cdd:PRK10365  91 TAVEALKTGALDYLIKPL---DFD----NLQATLEKALAHTHSIDAETPAVTASQFGMVGKSPAM 148
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 32-123 3.78e-04

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 39.18  E-value: 3.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152  32 DIDCATFAGTDDFIESWKSGRFDLVLldcyltddeTDETTP--TGLDIARFLRKQRDDCPIVFITSSSDF--AVLGYEVQ 107
Cdd:cd19919   24 GLTVTSFENAQEALAALASSQPDVLI---------SDIRMPgmDGLALLAQIKQRHPDLPVIIMTAHSDLdsAVSAYQGG 94

                         90
                 ....*....|....*.
gi 736877152 108 AIGYLLKPvgradFDM 123
Cdd:cd19919   95 AFEYLPKP-----FDI 105
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 4-116 9.38e-04

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 37.96  E-value: 9.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   4 VAIVEDHPAERQLMKTMCtayfrekRGLDIDCATFAGTDDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARFLRK 83
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLL-------RSVGLAVKTFTSASAFLAAAPPDQPGCLVLDVRMPG-------MSGLELQDELLA 68

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 736877152  84 QRDDCPIVFITSSSD--FAVLGYEVQAIGYLLKPV 116
Cdd:cd17537   69 RGSNIPIIFITGHGDvpMAVEAMKAGAVDFLEKPF 103
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 4-115 1.39e-03

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 37.13  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   4 VAIVEDHPAERQLMKTMCTayfreKRGLDIDCATfaGTDDFIESWKSGRFDLVLLDCYLTDDetdettpTGLDIARFLRK 83
Cdd:cd19926    1 VLVVDDEPDIRELLEITLG-----RMGLDVRSAR--NVKEARELLASEPYDLCLTDMRLPDG-------SGLELVQHIQQ 66

                         90       100       110
                 ....*....|....*....|....*....|....
gi 736877152  84 QRDDCPIVFITS--SSDFAVLGYEVQAIGYLLKP 115
Cdd:cd19926   67 RLPQTPVAVITAygSLDTAIEALKAGAFDFLTKP 100
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 2-116 1.43e-03

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 37.42  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   2 MRVAIVEDHPAERQLMKTMCtayfrekrgLDIDCATFAGTDDFIE--SW-KSGRFDLVLLDcYLTDDetdettPTGLDIA 78
Cdd:cd17551    1 MRILIVDDNPTNLLLLEALL---------RSAGYLEVVSFTDPREalAWcRENPPDLILLD-YMMPG------MDGLEFI 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 736877152  79 RFLRKQR--DDCPIVFITSSSDFAVLgyeVQAI--G---YLLKPV 116
Cdd:cd17551   65 RRLRALPglEDVPIVMITADTDREVR---LRALeaGatdFLTKPF 106
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 3-116 1.92e-03

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 36.71  E-value: 1.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   3 RVAIVEDHPAERQLMKTMCTAyfrekRGLDIDCATfaGTDDFIESWKSGRFDLVLLDCYLTddETDettptGLDIARFLR 82
Cdd:cd17538    1 KILVVDDEPANRELLEALLSA-----EGYEVLTAD--SGQEALALAEEELPDLILLDVMMP--GMD-----GFEVCRRLK 66

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 736877152  83 KQRD--DCPIVFITSSSDFA--VLGYEVQAIGYLLKPV 116
Cdd:cd17538   67 EDPEtrHIPVIMITALDDREdrIRGLEAGADDFLSKPI 104
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 3-116 1.95e-03

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 37.18  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   3 RVAIVEDHPAERQLMktmcTAYFrEKRGLDIDCAtfAGTDDFIESWKSGRFDLVLLDcyLTDDETDettptGLDIARFLR 82
Cdd:cd17555    2 TILVIDDDEVVRESI----AAYL-EDSGFQVLQA--ADGRQGLELFRSEQPDLVLCD--LRMPEMD-----GLEVLKQIT 67

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 736877152  83 KQRDDCPIVFITSSSdfaVLGYEVQAI-----GYLLKPV 116
Cdd:cd17555   68 KESPDTPVIVVSGAG---VMSDAVEALrlgawDYLTKPI 103
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 29-115 1.97e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 37.06  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152  29 RGLDIDCATFAGTDDFIESWKSGRFDLVLLDCYLTDDEtdettptGLDIARFLRKQrDDCPIVFITSSSDFA--VLGYEV 106
Cdd:cd17626   21 RGEGFDPAFCGDGTQALAAFREVRPDLVLLDLMLPGID-------GIEVCRQIRAE-SGVPIVMLTAKSDTVdvVLGLES 92


                 ....*....
gi 736877152 107 QAIGYLLKP 115
Cdd:cd17626   93 GADDYVAKP 101
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
4-127 1.97e-03

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 39.28  E-value: 1.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   4 VAIVEDHPAERQLMKTMCTAYFREKRGLdidcATFAGTDDFIESWKSgRFDLVLLDCYLTDDEtdettptglDIARFLRK 83
Cdd:PRK13837 700 VLLVEPDDATLERYEEKLAALGYEPVGF----STLAAAIAWISKGPE-RFDLVLVDDRLLDEE---------QAAAALHA 765

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 736877152  84 QRDDCPIVFITSSSDFAVLGyEVQAIG--YLLKPVGRADFDMTMDR 127
Cdd:PRK13837 766 AAPTLPIILGGNSKTMALSP-DLLASVaeILAKPISSRTLAYALRT 810
PRK10430 PRK10430
two-component system response regulator DcuR;
53-115 2.88e-03

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 38.17  E-value: 2.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736877152  53 FDLVLLDCYLTDDetdettpTGLDIARFLRKQRDDCPIVFITSSSDFAV----LGYEVqaIGYLLKP 115
Cdd:PRK10430  50 IDLILLDIYMQQE-------NGLDLLPVLHEAGCKSDVIVISSAADAATikdsLHYGV--VDYLIKP 107
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 27-117 3.18e-03

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 36.63  E-value: 3.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152  27 EKRGLDIDCAtFAGtDDFIESWKSGRFDLVLLDCYLTddETDettptGLDIARFLRKqRDDCPIVFITSS-SDF-AVLGY 104
Cdd:cd17614   19 TKEGYEVVTA-YDG-REALEKVEEEQPDLILLDLMLP--EKD-----GLEVCREVRK-TSNVPIIMLTAKdSEVdKVLGL 88

                         90
                 ....*....|...
gi 736877152 105 EVQAIGYLLKPVG 117
Cdd:cd17614   89 ELGADDYVTKPFS 101
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 2-126 3.63e-03

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 36.62  E-value: 3.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   2 MRVAIVEDHPAERQLMKTMCTAYFREKRGldidcatfAGTDDF--IESWKSGRFDLVLLDCYLTddETDettptGLDIAR 79
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGYEVVG--------EASDGEeaVELAKKHKPDLVIMDVKMP--RLD-----GIEAAK 65

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 736877152  80 FLRKQRDdCPIVFITSSSDFAVL--GYEVQAIGYLLKPVGRADFDMTMD 126
Cdd:cd19932   66 IITSENI-APIVLLTAYSQQDLVerAKEAGAMAYLVKPFSESDLIPAIE 113
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 3-130 3.67e-03

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 36.63  E-value: 3.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   3 RVAIVEDHPAERQLMKTMCtayfrEKRGLDIDCATFA-GTD--DFIEswKSGRF------DLVLLDCYLtddetdettP- 72
Cdd:cd17557    1 TILLVEDNPGDAELIQEAF-----KEAGVPNELHVVRdGEEalDFLR--GEGEYadaprpDLILLDLNM---------Pr 64

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 736877152  73 -TGLDIARFLRKQRDDCPI-VFITSSSDFA---VLGYEVQAIGYLLKPVGRADFDMTMDRVCE 130
Cdd:cd17557   65 mDGFEVLREIKADPDLRRIpVVVLTTSDAEediERAYELGANSYIVKPVDFEEFVEAIRSLGE 127
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 2-135 4.72e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 37.60  E-value: 4.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   2 MRVAIVEDhpaERQLMKTMCTAYfrEKRGLDIDCAtfagtDDFIESWK---SGRFDLVLLDCYLTDdetdettPTGLDIA 78
Cdd:PRK09836   1 MKLLIVED---EKKTGEYLTKGL--TEAGFVVDLA-----DNGLNGYHlamTGDYDLIILDIMLPD-------VNGWDIV 63

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 736877152  79 RFLRKQRDDCPIVFITS--SSDFAVLGYEVQAIGYLLKPVGRADFdmtMDRVcETLSKR 135
Cdd:PRK09836  64 RMLRSANKGMPILLLTAlgTIEHRVKGLELGADDYLVKPFAFAEL---LARV-RTLLRR 118
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 2-99 4.86e-03

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 36.04  E-value: 4.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736877152   2 MRVAIVEDHPAERQLmktmctayFREK---RGLDIDCATFAgtDDFIESWKSGRFDLVLLDCYLTDDEtdettptGLDIA 78
Cdd:cd17554    1 KKILVVDDEENIREL--------YKEEledEGYEVVTAGNG--EEALEKLESEDPDLVILDIKMPGMD-------GLETL 63

                         90       100
                 ....*....|....*....|.
gi 736877152  79 RFLRKQRDDCPIVFITSSSDF 99
Cdd:cd17554   64 RKIREKKPDLPVIICTAYSEY 84
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
 27-94 5.89e-03

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 38.00  E-value: 5.89e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 736877152  27 EKRGLDIDCAtFAGtDDFIESWKSGRFDLVLLDCYLTDdetdettPTGLDIARFLRKQ--RDDC-PIVFIT 94
Cdd:PRK11091 546 EKLGNSVDVA-MTG-KEALEMFDPDEYDLVLLDIQLPD-------MTGLDIARELRERypREDLpPLVALT 607
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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