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Conserved domains on  [gi|736698106|ref|WP_034703664|]
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MULTISPECIES: Lrp/AsnC family transcriptional regulator [Acinetobacter]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

CATH:  3.30.70.920|1.10.10.10
Gene Ontology:  GO:0043565
PubMed:  16438681|21608015|27206730

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 4.31e-38

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 126.43  E-value: 4.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736698106   1 MDKFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLEQKGIILGYSACIHPEALGIAVLAMVQVNLKTHDAAaki 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD--- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 736698106  81 AFQQLIEEEEAIQEAFSLSGDADFMLKVGAKNLEMLANFVTEKLLSCNFIGHIKSYIVL 139
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 4.31e-38

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 126.43  E-value: 4.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736698106   1 MDKFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLEQKGIILGYSACIHPEALGIAVLAMVQVNLKTHDAAaki 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD--- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 736698106  81 AFQQLIEEEEAIQEAFSLSGDADFMLKVGAKNLEMLANFVTEKLLSCNFIGHIKSYIVL 139
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-108 1.42e-23

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 88.73  E-value: 1.42e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736698106     1 MDKFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLEQKGIILGYSACIHPEALGIAVLAMVQVNLKTHDAAAKI 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 736698106    81 AfQQLiEEEEAIQEAFSLSGDADFMLKV 108
Cdd:smart00344  81 L-EKL-EKLPEVEEVYLVTGDYDYLLKV 106
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-144 5.40e-18

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 75.95  E-value: 5.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736698106   1 MDKFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLEQKGIILGYSACIHPEALGIAVLAMVQVNLK--THDAAA 78
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNrgAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736698106  79 KI--AFQQLIEEEEAIQeafsLSGDADFMLKVGAKNLEMLANFVTEKLLSCNFIGHIKSYIVLNKFKQ 144
Cdd:PRK11169  92 QFnaAVQKLEEIQECHL----VSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQ 155
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 1.29e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 61.23  E-value: 1.29e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 736698106    2 DKFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-50 3.60e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.58  E-value: 3.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 736698106   7 KIIQALQKNGrLTNQEIGDLIGLSASQCSRRRQLLEQKGIILGY 50
Cdd:cd00090   11 RILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 4.31e-38

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 126.43  E-value: 4.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736698106   1 MDKFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLEQKGIILGYSACIHPEALGIAVLAMVQVNLKTHDAAaki 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKVPPHRLD--- 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 736698106  81 AFQQLIEEEEAIQEAFSLSGDADFMLKVGAKNLEMLANFVTEKLLSCNFIGHIKSYIVL 139
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
 1-108 1.42e-23

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 88.73  E-value: 1.42e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736698106     1 MDKFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLEQKGIILGYSACIHPEALGIAVLAMVQVNLKTHDAAAKI 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDKLEEF 80

                           90       100
                   ....*....|....*....|....*...
gi 736698106    81 AfQQLiEEEEAIQEAFSLSGDADFMLKV 108
Cdd:smart00344  81 L-EKL-EKLPEVEEVYLVTGDYDYLLKV 106
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-144 5.40e-18

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 75.95  E-value: 5.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736698106   1 MDKFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLEQKGIILGYSACIHPEALGIAVLAMVQVNLK--THDAAA 78
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNrgAPDVFE 91

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 736698106  79 KI--AFQQLIEEEEAIQeafsLSGDADFMLKVGAKNLEMLANFVTEKLLSCNFIGHIKSYIVLNKFKQ 144
Cdd:PRK11169  92 QFnaAVQKLEEIQECHL----VSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQ 155
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 1.29e-13

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 61.23  E-value: 1.29e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 736698106    2 DKFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
3-47 2.24e-11

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 55.52  E-value: 2.24e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 736698106    3 KFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLEQKGII 47
Cdd:pfam13412   1 ETDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
 96-140 3.95e-08

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 47.52  E-value: 3.95e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 736698106   96 FSLSGDADFMLKVGAKNLEMLANFVTEKLLSCNFIGHIKSYIVLN 140
Cdd:pfam01037  28 YRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLS 72
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
 1-80 1.82e-05

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 42.39  E-value: 1.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736698106   1 MDKFDWKIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLEQKGIILGYSACIHPEALGIAVLAMVQVNLKT----HDA 76
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDVCCFIGIILKSakdyPSA 86


                 ....
gi 736698106  77 AAKI 80
Cdd:PRK11179  87 LAKL 90
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 5-47 4.88e-05

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 39.51  E-value: 4.88e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 736698106   5 DWKIIQALQKN-GRLTNQEIGDLIGLSASQCSRRRQLLEQKGII 47
Cdd:COG2512   17 ERRVLELLRENgGRMTQSEIVKETGWSKSKVSRLLSRLEERGLI 60
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
7-47 1.63e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 36.78  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 736698106   7 KIIQALQKNGRLTNQEIGDLIGLSASQCSRRRQLLEQKGII 47
Cdd:COG3398  101 RILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLV 141
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 7-50 3.60e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.58  E-value: 3.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 736698106   7 KIIQALQKNGrLTNQEIGDLIGLSASQCSRRRQLLEQKGIILGY 50
Cdd:cd00090   11 RILRLLLEGP-LTVSELAERLGLSQSTVSRHLKKLEEAGLVESR 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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