NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|736568523|ref|WP_034580311|]
View 

MULTISPECIES: TetR/AcrR family transcriptional regulator [Acinetobacter]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 10451993)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 63-208 8.32e-37

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


:

Pssm-ID: 433616  Cd Length: 143  Bit Score: 126.59  E-value: 8.32e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736568523   63 YQHQTLEMLALPEDRALDANDKIHYFQVLSSQLWAYRFLHRDVYHLVENNEDFRKLYPRFAGQVMQQGQKIYKAFVNAGL 142
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736568523  143 MEMTDSEIEALIINLWIVLTNWTNFLYmsgHITDSNTLEEKWVWQALRQMVFLEGAYLRGESRQTY 208
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQR---TQAPEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
13-59 1.33e-11

Bacterial regulatory proteins, tetR family;


:

Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 57.80  E-value: 1.33e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 736568523   13 ILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKEL 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 63-208 8.32e-37

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 126.59  E-value: 8.32e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736568523   63 YQHQTLEMLALPEDRALDANDKIHYFQVLSSQLWAYRFLHRDVYHLVENNEDFRKLYPRFAGQVMQQGQKIYKAFVNAGL 142
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736568523  143 MEMTDSEIEALIINLWIVLTNWTNFLYmsgHITDSNTLEEKWVWQALRQMVFLEGAYLRGESRQTY 208
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQR---TQAPEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
3-155 7.30e-18

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 77.63  E-value: 7.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736568523   3 QTKTLKTKERILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKELMEQYQHQTLEML--ALPEDRALD 80
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALeeALAAEDPRE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736568523  81 ANDKI--HYFQVLSSQLWAYRFLHRDVYHLVENNEDFRKLYPRFAGQVMQqgqkiykAFVNAGLMEMTDSEIEALII 155
Cdd:COG1309   81 RLRALlrAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAE-------LLRAGGLLADVDPDALARAL 150
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
13-59 1.33e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 57.80  E-value: 1.33e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 736568523   13 ILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKEL 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
8-105 8.48e-09

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 53.75  E-value: 8.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736568523   8 KTKERILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKELMEQyQHQTLEmLALPEDRALDANdkihY 87
Cdd:NF041196   6 RTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE-QVARLR-EAVEPQRAGGGS----K 79

                         90       100
                 ....*....|....*....|
gi 736568523  88 FQVL--SSQLWAYRfLHRDV 105
Cdd:NF041196  80 LQELvdLTHVLARR-LRTDP 98
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
8-99 1.00e-07

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 50.71  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736568523   8 KTKERILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKELMEQYQHQTLEMLALPEDRALDANDKIH- 86
Cdd:COG3226    8 ERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEa 87

                         90
                 ....*....|...
gi 736568523  87 YFQVLSSQLWAYR 99
Cdd:COG3226   88 LADLLAELLPADR 100
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 7-62 2.42e-06

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 46.92  E-value: 2.42e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 736568523   7 LKTKERILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKELMEQ 62
Cdd:PRK10668  10 QETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWEL 65
 
Name Accession Description Interval E-value
TetR pfam13972
Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is ...
 63-208 8.32e-37

Bacterial transcriptional repressor; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity. The regulatory network in which TetR itself is involved is in being released in the presence of tetracycline, binding to the target operator, and repressing tetA transcription.


Pssm-ID: 433616  Cd Length: 143  Bit Score: 126.59  E-value: 8.32e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736568523   63 YQHQTLEMLALPEDRALDANDKIHYFQVLSSQLWAYRFLHRDVYHLVENNEDFRKLYPRFAGQVMQQGQKIYKAFVNAGL 142
Cdd:pfam13972   1 YEEELLELLRPPSDRPLTLEDLWLYLHALFELMWRYRFLYRDLPDLLSRNPELAKRYRQLLARLLATLRALLQGLVEAGL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 736568523  143 MEMTDSEIEALIINLWIVLTNWTNFLYmsgHITDSNTLEEKWVWQALRQMVFLEGAYLRGESRQTY 208
Cdd:pfam13972  81 LQADDEELEALADNIWLVATYWLSYQR---TQAPEAALTEAALRRGVYQVLSLLAPYLTPEGREAF 143
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
3-155 7.30e-18

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 77.63  E-value: 7.30e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736568523   3 QTKTLKTKERILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKELMEQYQHQTLEML--ALPEDRALD 80
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALeeALAAEDPRE 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 736568523  81 ANDKI--HYFQVLSSQLWAYRFLHRDVYHLVENNEDFRKLYPRFAGQVMQqgqkiykAFVNAGLMEMTDSEIEALII 155
Cdd:COG1309   81 RLRALlrAYLEFLAENPALARLLLAEAAELPELRAALRALLRRLRALLAE-------LLRAGGLLADVDPDALARAL 150
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
13-59 1.33e-11

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 57.80  E-value: 1.33e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 736568523   13 ILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKEL 59
Cdd:pfam00440   1 ILDAARELFAERGYDATTVREIAKRAGVSKGALYRYFGSKEELLEAL 47
ScbR_bind_reg NF041196
ScbR family autoregulator-binding transcription factor;
8-105 8.48e-09

ScbR family autoregulator-binding transcription factor;


Pssm-ID: 469100 [Multi-domain]  Cd Length: 191  Bit Score: 53.75  E-value: 8.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736568523   8 KTKERILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKELMEQyQHQTLEmLALPEDRALDANdkihY 87
Cdd:NF041196   6 RTRRAILEAAAEVFDERGYAAATISDILERAGVTKGALYFHFSSKEALARAVLEE-QVARLR-EAVEPQRAGGGS----K 79

                         90       100
                 ....*....|....*....|
gi 736568523  88 FQVL--SSQLWAYRfLHRDV 105
Cdd:NF041196  80 LQELvdLTHVLARR-LRTDP 98
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
8-99 1.00e-07

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 50.71  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 736568523   8 KTKERILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKELMEQYQHQTLEMLALPEDRALDANDKIH- 86
Cdd:COG3226    8 ERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARLRALLAAADDLEDAAEa 87

                         90
                 ....*....|...
gi 736568523  87 YFQVLSSQLWAYR 99
Cdd:COG3226   88 LADLLAELLPADR 100
PRK10668 PRK10668
DNA-binding transcriptional repressor AcrR; Provisional
 7-62 2.42e-06

DNA-binding transcriptional repressor AcrR; Provisional


Pssm-ID: 182632 [Multi-domain]  Cd Length: 215  Bit Score: 46.92  E-value: 2.42e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 736568523   7 LKTKERILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKELMEQ 62
Cdd:PRK10668  10 QETRQHILDAALRLFSQQGVSATSLADIAKAAGVTRGAIYWHFKNKSDLFSEIWEL 65
PRK09975 PRK09975
DNA-binding transcriptional regulator EnvR; Provisional
 7-62 1.39e-05

DNA-binding transcriptional regulator EnvR; Provisional


Pssm-ID: 182177 [Multi-domain]  Cd Length: 213  Bit Score: 44.73  E-value: 1.39e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 736568523   7 LKTKERILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKELMEQ 62
Cdd:PRK09975  10 LKTRQELIETAIAQFALRGVSNTTLNDIADAANVTRGAIYWHFENKTQLFNEMWLQ 65
slmA PRK09480
division inhibitor protein; Provisional
 5-52 8.92e-04

division inhibitor protein; Provisional


Pssm-ID: 181894 [Multi-domain]  Cd Length: 194  Bit Score: 39.02  E-value: 8.92e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 736568523   5 KTLKTKER---ILQ-LSLQLFNERGERsVTTNHIAAELGMSPGNLYYHFRNK 52
Cdd:PRK09480   4 KRPKKGERreqILQaLAQMLESPPGER-ITTAKLAARVGVSEAALYRHFPSK 54
PRK13756 PRK13756
TetR family transcriptional regulator;
10-62 1.02e-03

TetR family transcriptional regulator;


Pssm-ID: 172294 [Multi-domain]  Cd Length: 205  Bit Score: 39.10  E-value: 1.02e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 736568523  10 KERILQLSLQLFNERGERSVTTNHIAAELGMSPGNLYYHFRNKNEIIKELMEQ 62
Cdd:PRK13756   6 KEKVIDSALELLNEVGIEGLTTRKLAQKLGVEQPTLYWHVKNKRALLDALAIE 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH