|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
11-467 |
5.60e-131 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 387.55 E-value: 5.60e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 11 TARWLPWVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFS 90
Cdd:PRK10504 7 SVRWQLWIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFT 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 91 IGSLLCALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWI 170
Cdd:PRK10504 87 LGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWI 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 171 FLINLPVGMIGCYAVWKFIPDLRGSERtRFDGLGFLLFGAAMVLITIAMEGLGELHLPHLRVILLLFGGFACLAAYWLRA 250
Cdd:PRK10504 167 FLINIPVGIIGAIATLMLMPNYTMQTR-RFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 251 GHIDNPLFSPVLFKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLG 330
Cdd:PRK10504 246 RNNNRALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 331 YRIVLTGNTLALGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLG 410
Cdd:PRK10504 326 YRRVLVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIG 405
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 734884162 411 VACAGALLGGFTAEAGNDGVNTVLGAFQLTFLTVGLMAMLAAAIFLQLSPKDGKRVV 467
Cdd:PRK10504 406 VTIAGLLLGLFGQQHVSVDSGATHTVFMYTYLCMALIIALPALIFARVPNDTHQNVA 462
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
19-459 |
9.03e-71 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 229.38 E-value: 9.03e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 19 VAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCAL 98
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 99 SSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVG 178
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 179 MIGCYAVwkfipdlrgsertrfdglgfllfgaamvlitiameglgelhlphlrvilllfggfaclaaywlraghidnPLF 258
Cdd:cd17503 161 ILALLLA----------------------------------------------------------------------PLL 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 259 SPVLFKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLTGN 338
Cdd:cd17503 171 DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAG 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 339 TLALGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLGVACAGALL 418
Cdd:cd17503 251 LLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLL 330
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 734884162 419 GGFTAEAGNDGVNTVLG---------AFQLTFLTVGLMAMLAAAIFLQLS 459
Cdd:cd17503 331 TNRTQFHHSRLSELLAQqvqkqaliiAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
18-424 |
4.47e-54 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 188.36 E-value: 4.47e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 18 VVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCA 97
Cdd:TIGR00711 6 VLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 98 LSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPV 177
Cdd:TIGR00711 86 VAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 178 GMIGCYAVWKFIPDLRGSERTRFDGLGFLLFGAAMVLITIAMEGLGELHLPHLRVILLL-FGGFACLAAYWLRAGHIDNP 256
Cdd:TIGR00711 166 GIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPERGWFDSNEILILsITGLVAIIAFVVWELTDDNP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 257 LFSPVLFKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLt 336
Cdd:TIGR00711 246 LVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLV- 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 337 gnTLALGLMLASMGL----VSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLGVA 412
Cdd:TIGR00711 325 --TIGLILYAVGFYWraftFTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTA 402
|
410
....*....|..
gi 734884162 413 CAGALLGGFTAE 424
Cdd:TIGR00711 403 LITTILTNRTQF 414
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
19-456 |
9.68e-43 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 155.02 E-value: 9.68e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 19 VAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCAL 98
Cdd:cd17321 1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 99 SSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVG 178
Cdd:cd17321 81 APSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 179 MIgcyavwkfipdlrgsertrfdglgfllfgaamvlitiameglgelhlphlrvilllfggfaclaaywlraghidnplf 258
Cdd:cd17321 161 LV------------------------------------------------------------------------------ 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 259 spVLFKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLTGN 338
Cdd:cd17321 163 --ALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 339 TLALGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLGVACAGALL 418
Cdd:cd17321 241 LLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALL 320
|
410 420 430
....*....|....*....|....*....|....*....
gi 734884162 419 GGFTAEAGNDGVNTVLGAFQLTFLTVGL-MAMLAAAIFL 456
Cdd:cd17321 321 TAGLSANLGDSGVAALLSAAAAAFAAGFhLAFLVAAALA 359
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-405 |
1.82e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 120.85 E-value: 1.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 6 PLDAKTARWLPWVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGA 85
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 86 IMLFSIGSLLCALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYL 165
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 166 TWHWIFLINLPVGMIGCYAVWKFIPDLRGSERTRFDGlgfllfgaamvlitiameglgelhlphlrvilllfggfaclaa 245
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRG------------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 246 ywlraghidnplFSPVLFKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPL 325
Cdd:COG2814 199 ------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 326 IERLGYRIVLtgnTLALGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQL 405
Cdd:COG2814 267 ADRFGRRRLL---LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
19-412 |
8.42e-26 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 107.65 E-value: 8.42e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 19 VAIAFFMQSLDGTILNTALPAMAQDLAENPLrMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCAL 98
Cdd:cd17502 1 LMLALFLAALDQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 99 SSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVG 178
Cdd:cd17502 80 APNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 179 MIGCYAVwkfipdlrgsertrfdglgfllfgaamvlitiameglgelhlphlrvilllfggfaclaaywlraghidnplf 258
Cdd:cd17502 160 GLALALL------------------------------------------------------------------------- 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 259 spvlfktRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLG-YRIVLTG 337
Cdd:cd17502 167 -------RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVI 239
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 734884162 338 NTLALGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLGVA 412
Cdd:cd17502 240 GTILMSVGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVA 314
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-293 |
1.24e-24 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 103.35 E-value: 1.24e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 1 MPNRAPLDAKTARWLPWVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKK 80
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 81 IFFGAIMLFSIGSLLCALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGW 160
Cdd:COG0477 81 VLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 161 MVQYLTWHWIFLINLPVGMIGCYAVWKFIPDLRGSERTRFDGLGFLLFGAAMVLITIAMEGLGELHLPHLRVILLLFGGF 240
Cdd:COG0477 161 LVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 734884162 241 ACLAAYWLRAGHIDNPLFSPVLFKTRTFAVGILGNLFARLGSGALPFLVPLLL 293
Cdd:COG0477 241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
19-458 |
2.49e-21 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 95.34 E-value: 2.49e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 19 VAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCAL 98
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 99 SSSLSMLVGARVIQGLGGAlMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVG 178
Cdd:cd17504 81 APNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 179 MIGCYAVwkfipdlrgsertrfdglgfllfgaamvlitiameglgelhlphlrvilllfggfaclaaywlraghidnPLF 258
Cdd:cd17504 160 VLLAALV----------------------------------------------------------------------PLI 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 259 SPVLFKTRTFAVGILGNLFARLGSGALPFLVPLLLQ----VALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIV 334
Cdd:cd17504 170 DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRV 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 335 LTGNTLALGLMLASMGLVSeqTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLGVACA 414
Cdd:cd17504 250 LLIGLVISAVGLLLLALLH--SSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIA 327
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 734884162 415 GALLGGFTAEAGNDGVNTvLGAFQLTFLTVGLMAMLAAAIFLQL 458
Cdd:cd17504 328 GAILTTYTVSITSGGVPT-EGAYVLAFLIGAALALAALLLSLLI 370
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
19-410 |
7.85e-19 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 87.47 E-value: 7.85e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 19 VAIAFFMQSLDGTILNTALP-AMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCA 97
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 98 LSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPV 177
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 178 GMIGCYAVWKFIPDLRGSERTRFDGLGFLLFGAAMVLitiameglgeLHLPHLRVILLLFGGFACLAaywlraghidnpl 257
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKAL----------LRDPVLWLLLALLLFGFAFF------------- 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 258 fspvlfktrtfavgilgnlfarlgsgALPFLVPLLLQVaLGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLTG 337
Cdd:pfam07690 218 --------------------------GLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 734884162 338 NTLALGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLG 410
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
13-418 |
1.19e-14 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 75.92 E-value: 1.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 13 RWLPWVVAIAFFMQ-SLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSI 91
Cdd:PRK14995 4 QWLTLVIIVLVYIPvAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 92 GSLLCALSSSLSMLVGARVIQGLGGALMLPvGRLVVLRAYPRSELVRIM--GFITIPGLLGPLLGPTMGGWMVQYLTWHW 169
Cdd:PRK14995 84 ASLAAAFSPTASWLIATRALLAIGAAMIVP-ATLAGIRATFTEEKQRNMalGVWAAVGSGGAAFGPLVGGILLEHFYWGS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 170 IFLINLPVGMIGCYAVWKFIPDLRGSERTRFDGLGFLLFGAAMVLITIAMEGLGELHLPHLRVILLLFGGFACLAAYWLR 249
Cdd:PRK14995 163 VFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFIRT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 250 AGHIDNPLFSPVLFKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERL 329
Cdd:PRK14995 243 QLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 330 GYRIVLTGNTLALGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSL 409
Cdd:PRK14995 323 GLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGL 402
|
....*....
gi 734884162 410 GVACAGALL 418
Cdd:PRK14995 403 GIAIFGLLL 411
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
10-464 |
7.13e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 72.98 E-value: 7.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 10 KTARWLPWVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLF 89
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 90 SIGSLLCALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHW 169
Cdd:COG2271 86 GLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 170 IFLInlpvgmigcyavwkfipdlrgsertrfdglgfllFGAAMVLITIameglgelhlphLRVILLLFGGFACLAAYWlr 249
Cdd:COG2271 166 AFLI----------------------------------LGLPGLLLAL------------LRFWLLALAYFLVYFALY-- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 250 aghidnplfspvlfktrtfavgilgnlfarlgsgALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERL 329
Cdd:COG2271 198 ----------------------------------GFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 330 GYRIVLTGnTLALGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSL 409
Cdd:COG2271 244 GRRRKLVL-AIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGAL 322
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 734884162 410 GVACAGALLGGFtaeagndgvntvlgAFQLTFLTVGLMAMLAAAIFLQLSPKDGK 464
Cdd:COG2271 323 GPLLVGYLLDAT--------------GYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-456 |
9.41e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 72.61 E-value: 9.41e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 19 VAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCAL 98
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 99 SSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVG 178
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 179 MIGCYAVWKFIPDLRGSERTRFDGLGFLLFGAAMVLitiameglgelhlpHLRVILLLFGGFACLAaywlraghidnplf 258
Cdd:cd17325 161 LLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLL--------------RDRRLLALFLAIFVLA-------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 259 spvlfktrtfavgilgnlfarLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLTGN 338
Cdd:cd17325 213 ---------------------FAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIG 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 339 TLALGLMLASMGLVseqTPYPLLLAMLAVLGAINSLQFTAMNTVtlidLDDAQASSGNSLLSVVAQLSLSLGVAcAGALL 418
Cdd:cd17325 272 LLLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLVFPATLAL----LADIVPPEGRGTAMGLFNTAFSLGMV-LGPLL 343
|
410 420 430
....*....|....*....|....*....|....*...
gi 734884162 419 GGFTAEAGNdgvntvlgaFQLTFLTVGLMAMLAAAIFL 456
Cdd:cd17325 344 GGFLYDAFG---------FATPFLAAAALLLLAAVLFL 372
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
17-210 |
1.01e-13 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 72.42 E-value: 1.01e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 17 WVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLC 96
Cdd:TIGR00710 8 LLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 97 ALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLP 176
Cdd:TIGR00710 88 ALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSL 167
|
170 180 190
....*....|....*....|....*....|....
gi 734884162 177 VGMIGCYAVWKFIPDLRGSERTRFDGLGFLLFGA 210
Cdd:TIGR00710 168 AGILLSALIFFILPETLPYEARIQISTYFETFLL 201
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
31-420 |
5.73e-12 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 67.22 E-value: 5.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 31 TILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCALSSSLSMLVGARV 110
Cdd:cd17320 16 DMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 111 IQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVGMIGCYAVWKFIP 190
Cdd:cd17320 96 LQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 191 DLRGSERTRfdglgfllfgaamvlitiameglgelhlPHLRVILLLFGGfaclaaywlraghidnplfspvLFKTRTFAV 270
Cdd:cd17320 176 ETLPEEKRK----------------------------PLLSSLLRAYKR----------------------VLKNRRFLG 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 271 GILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYR---IVLTGNTLALGLMLA 347
Cdd:cd17320 206 YALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRrllRLGLLLLLAAALVLL 285
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 734884162 348 SMGLVSEQTPYPLLLAMLAVLGAInSLQFTAMNTVTLiDLDDAQASSGNSLLSVVAQLSLSLGVACAGALLGG 420
Cdd:cd17320 286 LAALLGGLSLWPLVAPLFLIFFGF-GLIFPNATSLAL-EPFPHVAGTASALLGFLQFLIGALAGALVGLLPNG 356
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
55-191 |
9.23e-12 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 62.67 E-value: 9.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 55 VIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRS 134
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 734884162 135 ELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVGMIGCYAVWKFIPD 191
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
21-417 |
1.34e-10 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 63.12 E-value: 1.34e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 21 IAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCALSS 100
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 101 SLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVGMI 180
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 181 GCYAVWKFIPDLRGSERTRFDGLGFLLFGAamvlITIAMEGLGELHLPHLRVILLLfggfaclaaywlraghidnplfsp 260
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGG----LLAEQQGKGPSTPKKYQIKELL------------------------ 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 261 vlfKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAG-MSMLP--LAAAAMFAKSIARPLIERLGYRIVLTG 337
Cdd:TIGR00893 213 ---KDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSILEAGfMASLPgiVGFIGMILGGRLSDLLLRRGKSLVFAR 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 338 NTLALGLMLASMGL-VSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLGVACAGA 416
Cdd:TIGR00893 290 KTAIIAGLVLSLLMfATNYVNIPYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGA 369
|
.
gi 734884162 417 L 417
Cdd:TIGR00893 370 I 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-442 |
2.12e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.06 E-value: 2.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 19 VAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCAL 98
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 99 SSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLT--WHWIFLINLP 176
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfgWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 177 VGMIGCYAVWKFIPDLRGSERTRFDGLGFLLFGAAMvlitiameglgelhlphlrvilllfggfaclaaywlraghidnp 256
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 257 lfsPVLFKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLT 336
Cdd:cd06174 197 ---KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 337 GntLALGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLGVACAGA 416
Cdd:cd06174 274 L--IGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGF 351
|
410 420
....*....|....*....|....*.
gi 734884162 417 LLGGFTAEAGNDGVNTVLGAFQLTFL 442
Cdd:cd06174 352 LLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
17-382 |
3.79e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 61.43 E-value: 3.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 17 WVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLC 96
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 97 ALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYlTWHWIFLInLP 176
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFL-LA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 177 VGMIGCYAVWKFIPDLRGSERTRFDGLGFLLFGAAMvlitiameglgelhlpHLRVILLLFGGFACLAaywlraghidnp 256
Cdd:cd17474 160 ALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKAL----------------RGRGLLTFLVSAFLYF------------ 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 257 lfspvlfktrtfavgilgnlfarLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIE-RLGYRIVL 335
Cdd:cd17474 212 -----------------------FLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRIL 268
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 734884162 336 TGNTLALGLMLASMGLVseqTPYPLLLAMLAVLGAINSLQFTAMNTV 382
Cdd:cd17474 269 VIGLLLYALSLLLLGFV---PSLALLLIAIVLFGLGLGLNLPLLTTL 312
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
17-456 |
4.06e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 61.44 E-value: 4.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 17 WVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVI-AYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLL 95
Cdd:cd17473 2 ITLLLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLtLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 96 CALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQyLTWHWIFLINL 175
Cdd:cd17473 82 GLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 176 pVGMIGCYAVWKFIPDLRGSERTrfdglgfllfgaamvliTIAMEGLGELHLPHLRVILLLFGGFACLAAYWlraghidn 255
Cdd:cd17473 161 -LALPVLILVLLFLPEPARKSKS-----------------AASPGAATAAALPWKRVLPIYFLAFLAMLLFY-------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 256 plfspvlfktrtfavgilgnlfarlgsgALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVL 335
Cdd:cd17473 215 ----------------------------VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 336 tgnTLALGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSvvaqLSLSLGvACAG 415
Cdd:cd17473 267 ---AIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVT----SAFFLG-QFLS 338
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 734884162 416 ALLGGFtaeagndgVNTVLGAFQLTFLTVGLMAMLAAAIFL 456
Cdd:cd17473 339 PLVLGP--------LVNLTGGLSGAFLILGVLALVLAIVLL 371
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
36-190 |
4.09e-10 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 61.47 E-value: 4.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 36 ALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCALSSSLSMLVGARVIQGLG 115
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 734884162 116 GALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVGMIGCYAVWKFIP 190
Cdd:PRK11102 93 AAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVFFFIP 167
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
31-456 |
5.86e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 57.63 E-value: 5.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 31 TILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFG-----AIMLFSIGSLLCALSSSLSML 105
Cdd:cd06173 16 WIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 106 VGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLIN--LPVGMIGCY 183
Cdd:cd06173 96 LVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINalSFLLSALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 184 AVWKFIPDLRGSERTRFdglgfllfgaamvLITIAMEGLGELHLPHLRVILLLFGGFACLAAywlraghidnplfspvlf 263
Cdd:cd06173 176 LFIRRPPPAAPGESSSL-------------LLRDLREGLRYLRRSPLLRLLLLALALFALLG------------------ 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 264 ktrtfavgilgnlfarlgsGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLTGNTLALG 343
Cdd:cd06173 225 -------------------GALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLG 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 344 LMLASMGLVseqTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLGVACAGALLGGFTA 423
Cdd:cd06173 286 LALLVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
|
410 420 430
....*....|....*....|....*....|...
gi 734884162 424 eagndgvntvlgafQLTFLTVGLMAMLAAAIFL 456
Cdd:cd06173 363 --------------SAVFLLAGALLLLAALLLL 381
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
17-439 |
1.39e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 56.40 E-value: 1.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 17 WVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLC 96
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 97 ALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLP 176
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 177 VGMIGCYAVWKFIPDLRGSERTRFDGLGFLLfgaamvlitiameglgeLHLPHLRVILLLFGGFACLAAYwlraghidnp 256
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPGSLGLLSSLL-----------------LLLRNPRLRLAYLITFLLFGGF---------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 257 lfspvlfktrtfavgilgnlfarlgSGALPFLVPLLLQVAlGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLT 336
Cdd:cd17324 215 -------------------------FALYTYLAPFLTDVP-GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLI 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 337 GNTLALGLMLASMGLvseqTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQlslsLGVACAGA 416
Cdd:cd17324 269 ALLLLAAALLLLTLL----GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYN----LGGALGAA 340
|
410 420
....*....|....*....|...
gi 734884162 417 LLGGFTAEAGNDGVNTVLGAFQL 439
Cdd:cd17324 341 LGGLVLDHGGWAGVGWVGAALLL 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-192 |
5.80e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 54.50 E-value: 5.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 10 KTARWLPWVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLF 89
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 90 SIGSLLCALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHW 169
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180
....*....|....*....|...
gi 734884162 170 IFLINLPVGMIGCYAVWKFIPDL 192
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDP 183
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
17-173 |
1.10e-07 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 53.73 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 17 WVVAIAFFMQS---LDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGS 93
Cdd:cd17319 3 RIIPLLFLAYVinyLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 94 LLCALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLI 173
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-418 |
1.88e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 53.40 E-value: 1.88e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 18 VVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQgVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCA 97
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTW-ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 98 LSSSLSMLVGARVIQGLGGALmLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQ--YLTWHWIFLINL 175
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGT-QGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEanAAGWRWIFYINA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 176 PV---GMIGCYAVWKFIPDLRGSERT------RFDGLGFLLFGAAMVLITIAMeGLGELHLP--HLRVILLLFGGFACL- 243
Cdd:cd06179 160 IFnalALILLFFFYHPPPRPQLHGSStrqklkRLDWVGLFLLIAGLVLFLLGL-SWGGNPYPwsSAHVIAPLVIGGVLLi 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 244 --AAYWLRAGHiDNPLFSPVLFKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSI 321
Cdd:cd06179 239 afGLYEWKGTK-DGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAIL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 322 ARPLIERLGY-RIVLTGNTLALGLMLASMGLVSEQTpYPLLLAMLAVLG-AINSLQFTAMNTVTLI--DLDDAQASsgnS 397
Cdd:cd06179 318 AGLLLTKIKHiKWQLVAGFVLFTAFLALLALITPDN-KALAIAFSVLAGiGIGGPLVLAIVIVQLSvpPEDIGTAS---G 393
|
410 420
....*....|....*....|.
gi 734884162 398 LLSVVAQLSLSLGVACAGALL 418
Cdd:cd06179 394 LLGSARALGGAVGTAIFTSIL 414
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
32-219 |
1.34e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.29 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 32 ILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCALSSSLSMLVGARVI 111
Cdd:cd17489 14 LLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 112 QGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVGMIGCYAVWkFIPD 191
Cdd:cd17489 94 HGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF-LVKD 172
|
170 180 190
....*....|....*....|....*....|....*...
gi 734884162 192 ----------LRGSERTRFDGLGFLLFGAAMVLITIAM 219
Cdd:cd17489 173 pppvaaeeaeAGTRAFRRLVEKKVLPPALILFLASIAY 210
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
196-474 |
4.44e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.74 E-value: 4.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 196 ERTRFDGLGFLLFGAAMVLITIA----MEGLGELHLPHLRVILLLFGGFACLAAYWLRAG-----HIDNPLFSP-----V 261
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLppplVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGtkerpVPEEEKVSLkeslkA 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 262 LFKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLTGNTLA 341
Cdd:COG2211 224 LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 342 LGLMLASMGLVSEQTPYPLLLAMLAVLGAINSLQFTAMNTVT-LIDLDDAQ-----ASSGNSLLSVVAQLSLSLGVACAG 415
Cdd:COG2211 304 AALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLAdVVDYDEWKtgrrrEGLYFGIFTFAIKLGQALAGALAG 383
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 734884162 416 ALLGGFTAEAGNDGVNTVLGAFQLTFLTVGLMAMLAAAIFLQLSPKDGKRVVSREHDIE 474
Cdd:COG2211 384 LLLALFGYVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELA 442
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-191 |
1.15e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 47.35 E-value: 1.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 8 DAKTARWLPWVVAIAF---FMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFG 84
Cdd:TIGR00895 8 KQPLSRYQWRAIILSFlimLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 85 AIMLFSIGSLLCALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQY 164
Cdd:TIGR00895 88 SILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPV 167
|
170 180
....*....|....*....|....*..
gi 734884162 165 LTWHWIFLINLPVGMIGCYAVWKFIPD 191
Cdd:TIGR00895 168 FGWRSLFYVGGIAPLLLLLLLMRFLPE 194
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
272-460 |
1.56e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 272 ILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLTGNTLALGLMLASMGL 351
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 352 VSEqtpYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVvaqlSLSLGVACaGALLGGFTAEAGndgvn 431
Cdd:cd17329 85 AHS---PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYW----AINLGVAI-GPLLGGLLLLYS----- 151
|
170 180
....*....|....*....|....*....
gi 734884162 432 tvlgaFQLTFLTVGLMAMLAAAIFLQLSP 460
Cdd:cd17329 152 -----FRLLFLAAAVLFLLAALVLLFLLP 175
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
18-174 |
2.81e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 46.10 E-value: 2.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 18 VVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCA 97
Cdd:cd17476 2 TISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 734884162 98 LSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRI-MGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLIN 174
Cdd:cd17476 82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIvFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFL 159
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
20-190 |
4.53e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 45.62 E-value: 4.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 20 AIAFFMQSLDGTILNTALPAMAQDLAENpLRMQGVV-----IAYMLTVALlipaSGWIADRFGTKKIFFGAIMLFSIGSL 94
Cdd:cd17380 5 FLATCICYADRVNMPIAIVPMAKEFGWS-KTDQGLVlssffWGYALTQVL----GGYLADRFGGKKVLLLAVALWSLATL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 95 L--CALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFL 172
Cdd:cd17380 80 LtpLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFY 159
|
170
....*....|....*...
gi 734884162 173 INLPVGMIGCYAVWKFIP 190
Cdd:cd17380 160 FFGLLGLLWALVWLIYLP 177
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
293-456 |
1.00e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 44.46 E-value: 1.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 293 LQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLTgntLALGLMLASMGLVSEQTPYPLLLAMLAVLGAIN 372
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLL---LGLLLMALGLLLFALAPSYPLLLLALFLLGLGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 373 SLQFTAMNTVtlidLDDAQASSGNSLLSvVAQLSLSLGVACAGALLGGFTAEAGNDGVntvlgafQLTFLTVGLMAMLAA 452
Cdd:COG0738 111 GLLDVAANPY----VAALGPETAASRLN-LLHAFFSLGALLGPLLGGLLILLGLSLSW-------HLPYLILAVLLLLLA 178
|
....
gi 734884162 453 AIFL 456
Cdd:COG0738 179 LLFL 182
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
31-199 |
1.23e-04 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 44.13 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 31 TILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLCALSSSLSMLVGARV 110
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 111 IQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLPVGMIGCYAVWKFIP 190
Cdd:PRK11652 105 IQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMP 184
|
....*....
gi 734884162 191 DLRGSERTR 199
Cdd:PRK11652 185 ETRPADARR 193
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-173 |
1.33e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.10 E-value: 1.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 17 WVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVI-AYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLL 95
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFgAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 734884162 96 CALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLI 173
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-401 |
2.83e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 42.92 E-value: 2.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 10 KTARWLPWVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLF 89
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 90 SIGSLLCALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSElVRIMGFITIPGLLGPLLGPTMGGWMVQY---LT 166
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA-ASRLNLLHAFFSLGALLGPLLGGLLILLglsLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 167 WHWIFLInlpvgmigcyavwkfipdlrgsertrfdgLGFLLFGAAMVLITIAMEGLGELHlphlrvilllfggfaclaay 246
Cdd:COG0738 163 WHLPYLI-----------------------------LAVLLLLLALLFLRSKLPEIEEEE-------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 247 wlrAGHIDNPLFSPVLFKTRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLI 326
Cdd:COG0738 194 ---EEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLL 270
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 734884162 327 ERLGYRIVLTGNTLALGLMLASMGLVSeqtPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSV 401
Cdd:COG0738 271 KRFGPVRLLRLSALLAAVGLLLALLAP---GPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
272-426 |
4.58e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.22 E-value: 4.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 272 ILGNLFARLGSGALPFLVPLLLqVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLTGNTLALGLMLASMGL 351
Cdd:cd06173 5 WLAQLLSALGDWIFTVALPWLV-LQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLAL 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 734884162 352 V--SEQTPYPLLLAMLAVLGAINSLQFTAMNTVTLIDLDDAQASSGNSLLSVVAQLSLSLGVACAGALLGGFTAEAG 426
Cdd:cd06173 84 LalLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
17-180 |
7.46e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 41.79 E-value: 7.46e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 17 WVVAIAFFMQSLDGTILNTALPAMAQDLAENPLRMQGVVIAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLC 96
Cdd:cd17323 2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 97 ALSSSLSMLVGARVIQGLGGALMLPVGRLVVLRAYPRSELVRIMGFITIPGLLGPLLGPTMGGWMVQYLTWHWIFLINLP 176
Cdd:cd17323 82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
....
gi 734884162 177 VGMI 180
Cdd:cd17323 162 ISGF 165
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
233-383 |
8.21e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.43 E-value: 8.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 233 ILLLFGGFACLAAYWLRaghidnplfspvlfktRTFAVGILGNLFARLGSGALPFLVPLLLQVALGYSPSEAGMSMLPLA 312
Cdd:cd17316 160 ILFLIGALPALLALLLR----------------RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLIS 223
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 734884162 313 AAAMFAKSIARPLIERLGYRIVLTGNTLALGLMLASMGLVSEQTPYpLLLAMLAVLGAINSLQFTAMNTVT 383
Cdd:cd17316 224 LGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPT-LLLLLLFILSFFVGGVWGALYAYL 293
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
18-115 |
1.64e-03 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 40.63 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 18 VVAIAFFMQSLDGTILNTALPAMAQDLAENPLrMQGVVIAYMLTVALLIPA-SGWIADRFGTKKIFFGAIMLFSIGSLLC 96
Cdd:cd17359 5 VAALGGLLFGYDTGVINGALPFLQTDFNLTPF-LEGLVVSSALLGAAIGALfAGRLADRFGRRKTLLISAVLFFISALGS 83
|
90
....*....|....*....
gi 734884162 97 ALSSSLSMLVGARVIQGLG 115
Cdd:cd17359 84 AFSPNFTIFIIARIIGGLA 102
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
18-268 |
5.27e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 39.27 E-value: 5.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 18 VVAIAFFMQSLdgtilNTALPAMAQDLAENplRMQGVV-IAYMLTVALLIPASGWIADRFGTKKIFFGAIMLFSIGSLLC 96
Cdd:pfam06609 53 VCATYFVLQAS-----ASALPNILQDIGQS--ENQGLFsTLWTMGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVG 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 97 ALSSSLSMLVGARVIQGLG----GALMLPVGRLVvlrayprSELVRIMGFITIPGLLGPLLGptMGGWMVQYLT----WH 168
Cdd:pfam06609 126 CTANKFNTLLAAMTLLGVAagpaGASPLFIGELM-------SNKTKFLGLLIVSAPTIAMNG--AGPYFGQRLAiqgnWR 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 169 WIFLINLPVGMIGC--YAVWKFIPDLRG---------SERTRFDGLGFLLFGAAMVLITIAMEGLGELHLP--HLRVILL 235
Cdd:pfam06609 197 WIFYIYIIMSAIAVllIIIWYHPPSFAQlhgkkarkrDELAKLDWIGIFLVIAGTSLFLLGVSWGGKPNNPwnSAKIIGL 276
|
250 260 270
....*....|....*....|....*....|....*.
gi 734884162 236 LFGGFACLAAYWLRA--GHIDNPLFSPVLFK-TRTF 268
Cdd:pfam06609 277 ISSGAGSLVIFALYEvfGKPEQPIIPPALFKdTRGF 312
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|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
293-451 |
7.94e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 38.39 E-value: 7.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734884162 293 LQVALGYSPSEAGMSMLPLAAAAMFAKSIARPLIERLGYRIVLTGNTLALGLMLASMGLVSEqtpYPLLLAMLAVLGAIN 372
Cdd:cd17393 25 IKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLLGLAPS---VPALALALFLFGAAN 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 734884162 373 SLQFTAMNTVTLidldDAQASSGNSLLSVVAQLSlSLGvACAGALLGGFTAEAGNdGVNTVLGAFQLTFLTVGLMAMLA 451
Cdd:cd17393 102 GALDVAMNAQGV----AVERAYGRPIMSSLHAMW-SLG-GLAGALLGAAAIGAGV-SPGVHLLAAAVLLLLAALVAIRA 173
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