|
Name |
Accession |
Description |
Interval |
E-value |
| RobA_TF |
NF012228 |
MDR efflux pump AcrAB transcriptional activator RobA; The original characterization of RobA as ... |
3-282 |
8.90e-111 |
|
MDR efflux pump AcrAB transcriptional activator RobA; The original characterization of RobA as a Right side Origin of replication Binding protein A (robA) may be misleading. Characterizations in large numbers of papers since then treat RobA as a transcriptional activator of the AcrAB antibiotic efflux pump.
Pssm-ID: 467958 [Multi-domain] Cd Length: 286 Bit Score: 321.85 E-value: 8.90e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 3 QQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQF 82
Cdd:NF012228 1 QAGIIRDLLVWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGQAIGAYIRARRLSKAAVALRLTSRPILDIALQYRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 83 DSQQTFTRCFRKQFGLPPASYRRSQDWSSYGLQPPLRLTETPLPQADIVTLPAMQLVGHTQRRSFTLGQLAASKCELRRH 162
Cdd:NF012228 81 DSQQTFTRAFKKQFNQTPALYRRSEDWNAFGICPPIRLGKFTLPEPEFVTLPEQHLVGITQSYSCTLEQISDFRTEMRVQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 163 AWRQLLP-PQALPEVVYGLT----SLEVDRQRrgnpRMAYTAALPDEGA-----MGERVTIEQGEYARFTYQGQEEGLQN 232
Cdd:NF012228 161 FWRQYLGnTPTIPPVLYGLHhsrpSKEKDDEQ----EVLYTTALEPEHApegvqEGQPVVLEGGEYVQFTYEGPPEGLQD 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 727186711 233 FIVRLYDTAMPQMNAIRRPGQDIELFYPAQEGRCPLGGAAIRCEYLIPIR 282
Cdd:NF012228 237 FILTVYGTCMPTLNLTRRKGQDIERFYPHGDKKRDEPPTHIRCEYLIPIR 286
|
|
| PRK15121 |
PRK15121 |
MDR efflux pump AcrAB transcriptional activator RobA; |
1-283 |
4.14e-109 |
|
MDR efflux pump AcrAB transcriptional activator RobA;
Pssm-ID: 185076 [Multi-domain] Cd Length: 289 Bit Score: 317.72 E-value: 4.14e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 1 MHQQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTY 80
Cdd:PRK15121 1 MDQAGIIRDLLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 81 QFDSQQTFTRCFRKQFGLPPASYRRSQDWSSYGLQPPLRLTETPLPQADIVTLPAMQLVGHTQRRSFTLGQLAASKCELR 160
Cdd:PRK15121 81 RFDSQQTFTRAFKKQFAQTPALYRRSPEWSAFGIRPPIRLGEFTLPEHEFVTLPETPLVGVTQSYSCSLEQISDFRHEMR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 161 RHAWRQLL-PPQALPEVVYGL----TSLEVDRQRrgnpRMAYTAALPDEGAM-----GERVTIEQGEYARFTYQGQEEGL 230
Cdd:PRK15121 161 VQFWRDFLgNAPTIPPVLYGLhetrPSQEKDDEQ----EVFYTTALEPDQADgyvqtGHPVMLQGGEYVMFTYEGLGTGL 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 727186711 231 QNFIVRLYDTAMPQMNAIRRPGQDIELFYPAQEGRCPLGGAAIRCEYLIPIRR 283
Cdd:PRK15121 237 QEFILTVYGTCMPMLNLTRRKGQDIERYYPAEDAKAGDRPINLRCEYLIPIRR 289
|
|
| MarA_TF |
NF012198 |
MDR efflux pump AcrAB transcriptional activator MarA; |
7-104 |
6.30e-27 |
|
MDR efflux pump AcrAB transcriptional activator MarA;
Pssm-ID: 411088 Cd Length: 124 Bit Score: 101.75 E-value: 6.30e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 7 IEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQFDSQQ 86
Cdd:NF012198 11 IHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQ 90
|
90
....*....|....*...
gi 727186711 87 TFTRCFRKQFGLPPASYR 104
Cdd:NF012198 91 TLTRTFKNYFDVPPHKYR 108
|
|
| HTH_ARAC |
smart00342 |
helix_turn_helix, arabinose operon control protein; |
21-104 |
3.92e-20 |
|
helix_turn_helix, arabinose operon control protein;
Pssm-ID: 197666 [Multi-domain] Cd Length: 84 Bit Score: 82.60 E-value: 3.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 21 PLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQFDSQQTFTRCFRKQFGLPP 100
Cdd:smart00342 1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80
|
....
gi 727186711 101 ASYR 104
Cdd:smart00342 81 SEYR 84
|
|
| YdeE |
COG3708 |
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription] ... |
130-282 |
4.71e-18 |
|
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription];
Pssm-ID: 442922 Cd Length: 157 Bit Score: 79.29 E-value: 4.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 130 IVTLPAMQLVGHTQRRSFTLGQLAaskcELRRHAWRQL-------LPPQALPEVVYGLTSlevdRQRRGNPRMAYTAA-- 200
Cdd:COG3708 5 IVEKPAFKLVGLSARTSNSDEEAN----EEIPALWQRFlpeglaeIPNLSNPGGLYGVCT----DYESDEGEFDYLAGve 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 201 ------LPDEgaMgERVTIEQGEYARFTYQGQ-EEGLQNFIVRLYDTAMPQMNAIRRPGQDIELFYPAQEGRcplggAAI 273
Cdd:COG3708 77 vssfdeVPEG--L-ETLEIPAGTYAVFTHKGPmPEALQETWQYIYSEWLPSSGYERADGPDFEVYDERDDPS-----PDS 148
|
....*....
gi 727186711 274 RCEYLIPIR 282
Cdd:COG3708 149 EVEIWIPIK 157
|
|
| GyrI-like |
pfam06445 |
GyrI-like small molecule binding domain; This family contains the small molecule binding ... |
129-281 |
3.19e-13 |
|
GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.
Pssm-ID: 428947 Cd Length: 153 Bit Score: 65.89 E-value: 3.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 129 DIVTLPAMQLVGHTQRRSFTLGQLAASKCELRRHAWRQLLPPQalPEVVYGLTSLEVDRQRRGNPRMAYTAALPDEGAMG 208
Cdd:pfam06445 3 EIVELPAFRVAGLRHRGPYNEEGIGALWEELCAWASENGLSPA--PSPLIGVSYDDPEVTEDEELRYDAGVAVPIPVEGP 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727186711 209 ERV---TIEQGEYARFTYQGQEEGLQNFIVRLYDTAMPQMNAIRRPGQDIELFYPAqegRCPLGGAAIRCEYLIPI 281
Cdd:pfam06445 81 EGVeelELPGGEYAVFRHKGPYDDLQETYAKIYGEWLPESGYERRDGPSFEIYLND---PREVPEEELKTEIYIPV 153
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RobA_TF |
NF012228 |
MDR efflux pump AcrAB transcriptional activator RobA; The original characterization of RobA as ... |
3-282 |
8.90e-111 |
|
MDR efflux pump AcrAB transcriptional activator RobA; The original characterization of RobA as a Right side Origin of replication Binding protein A (robA) may be misleading. Characterizations in large numbers of papers since then treat RobA as a transcriptional activator of the AcrAB antibiotic efflux pump.
Pssm-ID: 467958 [Multi-domain] Cd Length: 286 Bit Score: 321.85 E-value: 8.90e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 3 QQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQF 82
Cdd:NF012228 1 QAGIIRDLLVWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGQAIGAYIRARRLSKAAVALRLTSRPILDIALQYRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 83 DSQQTFTRCFRKQFGLPPASYRRSQDWSSYGLQPPLRLTETPLPQADIVTLPAMQLVGHTQRRSFTLGQLAASKCELRRH 162
Cdd:NF012228 81 DSQQTFTRAFKKQFNQTPALYRRSEDWNAFGICPPIRLGKFTLPEPEFVTLPEQHLVGITQSYSCTLEQISDFRTEMRVQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 163 AWRQLLP-PQALPEVVYGLT----SLEVDRQRrgnpRMAYTAALPDEGA-----MGERVTIEQGEYARFTYQGQEEGLQN 232
Cdd:NF012228 161 FWRQYLGnTPTIPPVLYGLHhsrpSKEKDDEQ----EVLYTTALEPEHApegvqEGQPVVLEGGEYVQFTYEGPPEGLQD 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 727186711 233 FIVRLYDTAMPQMNAIRRPGQDIELFYPAQEGRCPLGGAAIRCEYLIPIR 282
Cdd:NF012228 237 FILTVYGTCMPTLNLTRRKGQDIERFYPHGDKKRDEPPTHIRCEYLIPIR 286
|
|
| PRK15121 |
PRK15121 |
MDR efflux pump AcrAB transcriptional activator RobA; |
1-283 |
4.14e-109 |
|
MDR efflux pump AcrAB transcriptional activator RobA;
Pssm-ID: 185076 [Multi-domain] Cd Length: 289 Bit Score: 317.72 E-value: 4.14e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 1 MHQQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTY 80
Cdd:PRK15121 1 MDQAGIIRDLLIWLEGHLDQPLSLDNVAAKAGYSKWHLQRMFKDVTGHAIGAYIRARRLSKAAVALRLTSRPILDIALQY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 81 QFDSQQTFTRCFRKQFGLPPASYRRSQDWSSYGLQPPLRLTETPLPQADIVTLPAMQLVGHTQRRSFTLGQLAASKCELR 160
Cdd:PRK15121 81 RFDSQQTFTRAFKKQFAQTPALYRRSPEWSAFGIRPPIRLGEFTLPEHEFVTLPETPLVGVTQSYSCSLEQISDFRHEMR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 161 RHAWRQLL-PPQALPEVVYGL----TSLEVDRQRrgnpRMAYTAALPDEGAM-----GERVTIEQGEYARFTYQGQEEGL 230
Cdd:PRK15121 161 VQFWRDFLgNAPTIPPVLYGLhetrPSQEKDDEQ----EVFYTTALEPDQADgyvqtGHPVMLQGGEYVMFTYEGLGTGL 236
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 727186711 231 QNFIVRLYDTAMPQMNAIRRPGQDIELFYPAQEGRCPLGGAAIRCEYLIPIRR 283
Cdd:PRK15121 237 QEFILTVYGTCMPMLNLTRRKGQDIERYYPAEDAKAGDRPINLRCEYLIPIRR 289
|
|
| PRK10219 |
PRK10219 |
superoxide response transcriptional regulator SoxS; |
1-106 |
6.24e-31 |
|
superoxide response transcriptional regulator SoxS;
Pssm-ID: 182314 [Multi-domain] Cd Length: 107 Bit Score: 111.56 E-value: 6.24e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 1 MHQQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTY 80
Cdd:PRK10219 1 MSHQKIIQTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDL 80
|
90 100
....*....|....*....|....*.
gi 727186711 81 QFDSQQTFTRCFRKQFGLPPASYRRS 106
Cdd:PRK10219 81 GYVSQQTFSRVFRRQFDRTPSDYRHR 106
|
|
| PRK11511 |
PRK11511 |
MDR efflux pump AcrAB transcriptional activator MarA; |
7-104 |
1.12e-28 |
|
MDR efflux pump AcrAB transcriptional activator MarA;
Pssm-ID: 236920 [Multi-domain] Cd Length: 127 Bit Score: 106.34 E-value: 1.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 7 IEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQFDSQQ 86
Cdd:PRK11511 11 IHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQ 90
|
90
....*....|....*...
gi 727186711 87 TFTRCFRKQFGLPPASYR 104
Cdd:PRK11511 91 TLTRTFKNYFDVPPHKYR 108
|
|
| MarA_TF |
NF012198 |
MDR efflux pump AcrAB transcriptional activator MarA; |
7-104 |
6.30e-27 |
|
MDR efflux pump AcrAB transcriptional activator MarA;
Pssm-ID: 411088 Cd Length: 124 Bit Score: 101.75 E-value: 6.30e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 7 IEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQFDSQQ 86
Cdd:NF012198 11 IHSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQ 90
|
90
....*....|....*...
gi 727186711 87 TFTRCFRKQFGLPPASYR 104
Cdd:NF012198 91 TLTRTFKNYFDVPPHKYR 108
|
|
| HTH_ARAC |
smart00342 |
helix_turn_helix, arabinose operon control protein; |
21-104 |
3.92e-20 |
|
helix_turn_helix, arabinose operon control protein;
Pssm-ID: 197666 [Multi-domain] Cd Length: 84 Bit Score: 82.60 E-value: 3.92e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 21 PLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQFDSQQTFTRCFRKQFGLPP 100
Cdd:smart00342 1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80
|
....
gi 727186711 101 ASYR 104
Cdd:smart00342 81 SEYR 84
|
|
| YdeE |
COG3708 |
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription] ... |
130-282 |
4.71e-18 |
|
Predicted transcriptional regulator YdeE, contains AraC-type DNA-binding domain [Transcription];
Pssm-ID: 442922 Cd Length: 157 Bit Score: 79.29 E-value: 4.71e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 130 IVTLPAMQLVGHTQRRSFTLGQLAaskcELRRHAWRQL-------LPPQALPEVVYGLTSlevdRQRRGNPRMAYTAA-- 200
Cdd:COG3708 5 IVEKPAFKLVGLSARTSNSDEEAN----EEIPALWQRFlpeglaeIPNLSNPGGLYGVCT----DYESDEGEFDYLAGve 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 201 ------LPDEgaMgERVTIEQGEYARFTYQGQ-EEGLQNFIVRLYDTAMPQMNAIRRPGQDIELFYPAQEGRcplggAAI 273
Cdd:COG3708 77 vssfdeVPEG--L-ETLEIPAGTYAVFTHKGPmPEALQETWQYIYSEWLPSSGYERADGPDFEVYDERDDPS-----PDS 148
|
....*....
gi 727186711 274 RCEYLIPIR 282
Cdd:COG3708 149 EVEIWIPIK 157
|
|
| GlxA |
COG4977 |
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ... |
2-105 |
7.28e-17 |
|
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];
Pssm-ID: 444002 [Multi-domain] Cd Length: 318 Bit Score: 79.05 E-value: 7.28e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 2 HQQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYarrrrltaaARELRL---------TGTS 72
Cdd:COG4977 207 HRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARY---------LQRLRLerarrlletTDLS 277
|
90 100 110
....*....|....*....|....*....|...
gi 727186711 73 VACIADTYQFDSQQTFTRCFRKQFGLPPASYRR 105
Cdd:COG4977 278 IEEIAAACGFGSASHFRRAFRRRFGVSPSAYRR 310
|
|
| AraC |
COG2207 |
AraC-type DNA-binding domain and AraC-containing proteins [Transcription]; |
2-107 |
1.91e-15 |
|
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
Pssm-ID: 441809 [Multi-domain] Cd Length: 258 Bit Score: 74.43 E-value: 1.91e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 2 HQQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQ 81
Cdd:COG2207 149 LLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELG 228
|
90 100
....*....|....*....|....*.
gi 727186711 82 FDSQQTFTRCFRKQFGLPPASYRRSQ 107
Cdd:COG2207 229 FSSQSHFSRAFKKRFGVTPSEYRKRL 254
|
|
| GyrI-like |
pfam06445 |
GyrI-like small molecule binding domain; This family contains the small molecule binding ... |
129-281 |
3.19e-13 |
|
GyrI-like small molecule binding domain; This family contains the small molecule binding domain of a number of different bacterial transcription activators. This family also contains DNA gyrase inhibitors. The GyrI superfamily contains a diad of the SHS2 module, adapted for small-molecule binding. The GyrI superfamily includes a family of secreted forms that is found only in animals and the bacterial pathogen Leptospira.
Pssm-ID: 428947 Cd Length: 153 Bit Score: 65.89 E-value: 3.19e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 129 DIVTLPAMQLVGHTQRRSFTLGQLAASKCELRRHAWRQLLPPQalPEVVYGLTSLEVDRQRRGNPRMAYTAALPDEGAMG 208
Cdd:pfam06445 3 EIVELPAFRVAGLRHRGPYNEEGIGALWEELCAWASENGLSPA--PSPLIGVSYDDPEVTEDEELRYDAGVAVPIPVEGP 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727186711 209 ERV---TIEQGEYARFTYQGQEEGLQNFIVRLYDTAMPQMNAIRRPGQDIELFYPAqegRCPLGGAAIRCEYLIPI 281
Cdd:pfam06445 81 EGVeelELPGGEYAVFRHKGPYDDLQETYAKIYGEWLPESGYERRDGPSFEIYLND---PREVPEEELKTEIYIPV 153
|
|
| HTH_18 |
pfam12833 |
Helix-turn-helix domain; |
27-106 |
1.19e-12 |
|
Helix-turn-helix domain;
Pssm-ID: 432818 [Multi-domain] Cd Length: 81 Bit Score: 62.22 E-value: 1.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 27 IAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAAREL-RLTGTSVACIADTYQFDSQQTFTRCFRKQFGLPPASYRR 105
Cdd:pfam12833 1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80
|
.
gi 727186711 106 S 106
Cdd:pfam12833 81 R 81
|
|
| AraC_E_bind |
smart00871 |
Bacterial transcription activator, effector binding domain; This domain is found in the ... |
130-282 |
7.57e-12 |
|
Bacterial transcription activator, effector binding domain; This domain is found in the probable effector binding domain of a number of different bacterial transcription activators.and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.
Pssm-ID: 214874 [Multi-domain] Cd Length: 158 Bit Score: 62.11 E-value: 7.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 130 IVTLPAMQLVGHTQRRSFTLGQLAASKCELRRHAWRQLLPPQALPEVVYGLTSLEVDRQRRGNPRMAYTAALPDEGAMGE 209
Cdd:smart00871 4 IVELPAFKVAGLRHRGPNEDEKIPELWQRLIQWAKELGLLPVGNSGEPYGVYYDDPDDTPDGEFRYDAGVEVSDEVEAPE 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727186711 210 RV---TIEQGEYARFTYQGQ-EEGLQNFIVRLYDTAMPQMNAIRRPGQDIELFYPAQEGRCPLggAAIRCEYLIPIR 282
Cdd:smart00871 84 GVetkTIPAGKYAVFTHKGGsYDEIQEAWEAIYGEWLPNSGYELRDAGPDFEVYLNDPPDTDP--EELVTEIYIPVK 158
|
|
| AdaA |
COG2169 |
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ... |
3-105 |
8.69e-12 |
|
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];
Pssm-ID: 441772 [Multi-domain] Cd Length: 358 Bit Score: 64.69 E-value: 8.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 3 QQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRlTGTSVACIADTYQF 82
Cdd:COG2169 82 RADLVARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQ-TGLSVTDAAYAAGF 160
|
90 100
....*....|....*....|...
gi 727186711 83 DSQQTFTRCFRKQFGLPPASYRR 105
Cdd:COG2169 161 GSLSRFYEAFKKLLGMTPSAYRR 183
|
|
| ftrA |
PRK09393 |
transcriptional activator FtrA; Provisional |
2-106 |
1.85e-09 |
|
transcriptional activator FtrA; Provisional
Pssm-ID: 181818 [Multi-domain] Cd Length: 322 Bit Score: 57.67 E-value: 1.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 2 HQQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQ 81
Cdd:PRK09393 215 RESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAG 294
|
90 100
....*....|....*....|....*
gi 727186711 82 FDSQQTFTRCFRKQFGLPPASYRRS 106
Cdd:PRK09393 295 FGSEESLRHHFRRRAATSPAAYRKR 319
|
|
| SbmC |
COG3449 |
DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair]; |
1-244 |
5.12e-09 |
|
DNA gyrase inhibitor GyrI/SbmC [Replication, recombination and repair];
Pssm-ID: 442672 [Multi-domain] Cd Length: 286 Bit Score: 56.02 E-value: 5.12e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 1 MHQQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTY 80
Cdd:COG3449 8 EADQRRRILLVLIALHDDLDLLLLALLLAFAFHFFFFHRRRRFRALIGRRARLLLRRRLLAALALLLLSSSAIIAAAAAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 81 QFDSQQTFTRCFRKQFGLPPASYRRSQDWSSYGLQPPLRLTETPLPQADIVTLPAMQLVGHTQRRSF-TLGQLAAskcel 159
Cdd:COG3449 88 SGYSSSASFRRFFRAFGGSSRSRRRRAKAKLLALPPLDPPRLEPMMDVEIKELPPRRVAYLRHRGPYeEIGEAFE----- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 160 RRHAW---RQLLPPQAL--------PEVVygltslEVDRQRrgnprmaYTAAL------PDEGAMGERvTIEQGEYARFT 222
Cdd:COG3449 163 RLIAWakaRGLLPPDSRtigiyyddPDIT------PPEKLR-------YDACVtvpedvALPGGVEVK-TIPGGRYAVLR 228
|
250 260
....*....|....*....|..
gi 727186711 223 YQGQEEGLQNFIVRLYDTAMPQ 244
Cdd:COG3449 229 HKGPYEDLGAAWDWLYGEWLPA 250
|
|
| PRK09685 |
PRK09685 |
DNA-binding transcriptional activator FeaR; Provisional |
9-106 |
2.28e-06 |
|
DNA-binding transcriptional activator FeaR; Provisional
Pssm-ID: 236612 [Multi-domain] Cd Length: 302 Bit Score: 48.10 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 9 QLLAWIEQSLDQP-LTLDDIAAKSGYSKWHLQRMFKQHtGHILGTYARRRRLTAAARELR--LTGTSVACIADTYQFDSQ 85
Cdd:PRK09685 201 KVVALIDQSIQEEiLRPEWIAGELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCADDLRpaADDEKITSIAYKWGFSDS 279
|
90 100
....*....|....*....|.
gi 727186711 86 QTFTRCFRKQFGLPPASYRRS 106
Cdd:PRK09685 280 SHFSTAFKQRFGVSPGEYRRK 300
|
|
| PRK13503 |
PRK13503 |
HTH-type transcriptional activator RhaS; |
7-108 |
7.42e-06 |
|
HTH-type transcriptional activator RhaS;
Pssm-ID: 184094 [Multi-domain] Cd Length: 278 Bit Score: 46.59 E-value: 7.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 7 IEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQFDSQQ 86
Cdd:PRK13503 173 LNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLLRHSDASVTDIAYRCGFGDSN 252
|
90 100
....*....|....*....|..
gi 727186711 87 TFTRCFRKQFGLPPASYRRSQD 108
Cdd:PRK13503 253 HFSTLFRREFSWSPRDIRQGRD 274
|
|
| PRK10371 |
PRK10371 |
transcriptional regulator MelR; |
2-105 |
2.89e-05 |
|
transcriptional regulator MelR;
Pssm-ID: 182416 [Multi-domain] Cd Length: 302 Bit Score: 44.81 E-value: 2.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 2 HQQQVIEQLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTYQ 81
Cdd:PRK10371 188 HAQFYVSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAG 267
|
90 100
....*....|....*....|....
gi 727186711 82 FDSQQTFTRCFRKQFGLPPASYRR 105
Cdd:PRK10371 268 FRSSSRFYSTFGKYVGMSPQQYRK 291
|
|
| HTH_AraC |
pfam00165 |
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ... |
14-47 |
7.46e-05 |
|
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.
Pssm-ID: 425497 [Multi-domain] Cd Length: 42 Bit Score: 39.44 E-value: 7.46e-05
10 20 30
....*....|....*....|....*....|....
gi 727186711 14 IEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTG 47
Cdd:pfam00165 1 LRENLSTNLTIADIADELGFSRSYFSRLFKKYTG 34
|
|
| Cass2 |
pfam14526 |
Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, ... |
130-281 |
1.08e-04 |
|
Integron-associated effector binding protein; This family contains Cass2 from Vibrio cholerae, an integron-associated protein that has been shown to bind cationic drug compounds with submicromolar affinity. Cass2 has been proposed to be representative of a larger family of independent effector-binding proteins associated with lateral gene transfer within Vibrio and other closely-related species.
Pssm-ID: 434016 [Multi-domain] Cd Length: 149 Bit Score: 41.57 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 130 IVTLPAMQLVGhtQRRSFTLGQLAASKcELRRhAWRQLLPPQALPEV-----VYGLtslEVDRQRRGNPRMAYTAALPDE 204
Cdd:pfam14526 2 IVELPSFTVAG--IRYEGPNEYEDHNK-EIGK-FWEEFNEDGRLPNIkkddkSYGI---YVDYEDEENEFDYYAGVEVPS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 205 GAMGER----VTIEQGEYARFTYQGQ-EEGLQNFIVRLYDTAMPQMNAIRRPGQDIELfYPAQegrcPLGGAAIrcEYLI 279
Cdd:pfam14526 75 FSELPEglvvIEIPGGKYAVFTIEGDfPDAIAEAWTRIYGWLLPNSGYERAGGPDFEV-YKEN----GDENMKI--ELYI 147
|
..
gi 727186711 280 PI 281
Cdd:pfam14526 148 PV 149
|
|
| PRK10572 |
PRK10572 |
arabinose operon transcriptional regulator AraC; |
1-106 |
1.25e-04 |
|
arabinose operon transcriptional regulator AraC;
Pssm-ID: 236717 [Multi-domain] Cd Length: 290 Bit Score: 42.65 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186711 1 MHQQQVIEqLLAWIEQSLDQPLTLDDIAAKSGYSKWHLQRMFKQHTGHILGTYARRRRLTAAARELRLTGTSVACIADTY 80
Cdd:PRK10572 180 PMDPRVRE-ACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNV 258
|
90 100
....*....|....*....|....*.
gi 727186711 81 QFDSQQTFTRCFRKQFGLPPASYRRS 106
Cdd:PRK10572 259 GYDDQLYFSRVFKKCTGASPSEFRAR 284
|
|
| HTH_AraC |
pfam00165 |
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ... |
69-105 |
6.25e-04 |
|
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.
Pssm-ID: 425497 [Multi-domain] Cd Length: 42 Bit Score: 36.75 E-value: 6.25e-04
10 20 30
....*....|....*....|....*....|....*..
gi 727186711 69 TGTSVACIADTYQFdSQQTFTRCFRKQFGLPPASYRR 105
Cdd:pfam00165 7 TNLTIADIADELGF-SRSYFSRLFKKYTGVTPSQYRH 42
|
|
| |
