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Conserved domains on  [gi|727186342|ref|WP_033648196|]
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MULTISPECIES: nuclear transport factor 2 family protein [Serratia]

Protein Classification

nuclear transport factor 2 family protein( domain architecture ID 10007626)

nuclear transport factor 2 (NTF2) family protein with a SnoaL-like polyketide cyclase domain

CATH:  3.10.450.50
SCOP:  4001306|3000472

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YesE COG3631
Ketosteroid isomerase-related protein [General function prediction only];
3-130 2.01e-32

Ketosteroid isomerase-related protein [General function prediction only];


:

Pssm-ID: 442849  Cd Length: 126  Bit Score: 110.79  E-value: 2.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186342   3 TPLEIVRATYEGSSEENGRNLLAALAPDAEWTEAaGFPYAGTYIGPENIIKnVHQRLGSEWQGYRADVDHFYDAGDNVIA 82
Cdd:COG3631    1 TNRELVRRFYAAFNAGDVDALLALLAEDVVWEDP-GGPGAGTYRGKEAVRA-FFARLAAAFEDLRFEVRRVVADGDRVVV 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 727186342  83 QGFYHGTYRATGKSFNASFAHIYTLRGGKIVKFVQIVDSAKVLEAMQP 130
Cdd:COG3631   79 EGTVRGTVLATGKPYENRYADVFTVRDGKIVRVREYFDTAALAAALGA 126
 
Name Accession Description Interval E-value
YesE COG3631
Ketosteroid isomerase-related protein [General function prediction only];
3-130 2.01e-32

Ketosteroid isomerase-related protein [General function prediction only];


Pssm-ID: 442849  Cd Length: 126  Bit Score: 110.79  E-value: 2.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186342   3 TPLEIVRATYEGSSEENGRNLLAALAPDAEWTEAaGFPYAGTYIGPENIIKnVHQRLGSEWQGYRADVDHFYDAGDNVIA 82
Cdd:COG3631    1 TNRELVRRFYAAFNAGDVDALLALLAEDVVWEDP-GGPGAGTYRGKEAVRA-FFARLAAAFEDLRFEVRRVVADGDRVVV 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 727186342  83 QGFYHGTYRATGKSFNASFAHIYTLRGGKIVKFVQIVDSAKVLEAMQP 130
Cdd:COG3631   79 EGTVRGTVLATGKPYENRYADVFTVRDGKIVRVREYFDTAALAAALGA 126
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
8-113 2.12e-12

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 58.84  E-value: 2.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186342    8 VRATYEGSSEENGRNLLAALAPDAEWTEAAGfpyagTYIGPENIIKNVhQRLGSEWQGYRADVDHFYDAGDNVIAQGFYH 87
Cdd:pfam12680   1 VRRFYEALNAGDLDALAALFAPDAVFHDPGG-----PLRGRDAIRAFF-AALFAAFPDLRFEIHDVIADGDRVAVRWTVT 74
                          90       100
                  ....*....|....*....|....*.
gi 727186342   88 GTYRATGKSFNASFAHIYTLRGGKIV 113
Cdd:pfam12680  75 GTIPPTGRGVRVRGVDVFRFRDGKIV 100
 
Name Accession Description Interval E-value
YesE COG3631
Ketosteroid isomerase-related protein [General function prediction only];
3-130 2.01e-32

Ketosteroid isomerase-related protein [General function prediction only];


Pssm-ID: 442849  Cd Length: 126  Bit Score: 110.79  E-value: 2.01e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186342   3 TPLEIVRATYEGSSEENGRNLLAALAPDAEWTEAaGFPYAGTYIGPENIIKnVHQRLGSEWQGYRADVDHFYDAGDNVIA 82
Cdd:COG3631    1 TNRELVRRFYAAFNAGDVDALLALLAEDVVWEDP-GGPGAGTYRGKEAVRA-FFARLAAAFEDLRFEVRRVVADGDRVVV 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 727186342  83 QGFYHGTYRATGKSFNASFAHIYTLRGGKIVKFVQIVDSAKVLEAMQP 130
Cdd:COG3631   79 EGTVRGTVLATGKPYENRYADVFTVRDGKIVRVREYFDTAALAAALGA 126
SnoaL_2 pfam12680
SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.
8-113 2.12e-12

SnoaL-like domain; This family contains a large number of proteins that share the SnoaL fold.


Pssm-ID: 432716 [Multi-domain]  Cd Length: 100  Bit Score: 58.84  E-value: 2.12e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186342    8 VRATYEGSSEENGRNLLAALAPDAEWTEAAGfpyagTYIGPENIIKNVhQRLGSEWQGYRADVDHFYDAGDNVIAQGFYH 87
Cdd:pfam12680   1 VRRFYEALNAGDLDALAALFAPDAVFHDPGG-----PLRGRDAIRAFF-AALFAAFPDLRFEIHDVIADGDRVAVRWTVT 74
                          90       100
                  ....*....|....*....|....*.
gi 727186342   88 GTYRATGKSFNASFAHIYTLRGGKIV 113
Cdd:pfam12680  75 GTIPPTGRGVRVRGVDVFRFRDGKIV 100
COG5485 COG5485
Predicted ester cyclase [General function prediction only];
7-113 1.37e-05

Predicted ester cyclase [General function prediction only];


Pssm-ID: 444236 [Multi-domain]  Cd Length: 130  Bit Score: 41.77  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186342   7 IVRATYEGSseENGRN---LLAALAPDAEWTeaagFPYAGTYIGPENIiKNVHQRLGSEWQGYRADVDHFYDAGDNVIAQ 83
Cdd:COG5485    1 LVRRFFEEA--WNEGDldaLDELVAPDFVYH----GPLPGEPRGPEGF-RAFLRGLRAAFPDLRFEIEDLIAEGDRVAVR 73
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727186342  84 GFYHGTYR-------ATGKSFNASFAHIYTLRGGKIV 113
Cdd:COG5485   74 WTFTGTHTgeflgipPTGKRVEFRGIDIYRFEDGKIV 110
SnoaL COG4538
Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];
1-114 1.21e-03

Uncharacterized conserved protein, contains SnoaL-like domain [Function unknown];


Pssm-ID: 443604  Cd Length: 113  Bit Score: 36.02  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727186342   1 MPTPLEIVRATYEGSseeNGRNL---LAALAPDAEWteaAGFPYAGTYIGPENIIKnVHQRLGSEWQGYRADVDHFYDAG 77
Cdd:COG4538    2 TMTPEDVVQRQLDAY---NARDIdafLATYADDAEV---YRFPGTLLAKGREAIRE-RYAERFANEPDLHAELVSRIVLG 74
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727186342  78 DNVIAQGfyHGTYRATGKSFNAsfAHIYTLRGGKIVK 114
Cdd:COG4538   75 NKVIDHE--LVTGLFGGGPVEV--VAIYEVEDGLIAR 107
SnoaL pfam07366
SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in ...
67-113 3.04e-03

SnoaL-like polyketide cyclase; This family includes SnoaL a polyketide cyclase involved in nogalamycin biosynthesis. This family was formerly known as DUF1486. The proteins in this family adopt a distorted alpha-beta barrel fold. Structural data together with site-directed mutagenesis experiments have shown that SnoaL has a different mechanism to that of the classical aldolase for catalysing intramolecular aldol condensation.


Pssm-ID: 399975  Cd Length: 126  Bit Score: 35.35  E-value: 3.04e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 727186342   67 RADVDHFYDAGDNVIAQGFYHGTYR-------ATGKSFNASFAHIYTLRGGKIV 113
Cdd:pfam07366  58 RFEVEDLVAEGDKVAARLTFTGTHTgeflgipPTGRKVRFRGIDLYRFEDGKIV 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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