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Conserved domains on  [gi|727184167|ref|WP_033646351|]
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MULTISPECIES: anti-virulence regulator CigR family protein [Serratia]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T3SS_CigR_fam NF040487
anti-virulence regulator CigR family protein; Members of this family are full-length homologs ...
 68-161 3.64e-63

anti-virulence regulator CigR family protein; Members of this family are full-length homologs of CigR, an inner membrane protein that appears to act as an anti-virulence factor. It was previously thought to be exported as a type III secretion system (T3SS) effector. A low-complexity, variable length repetitive region, rich in Gly, Pro, His, Lys, and Asn, separates a short, hydrophobic N-terminal domain from a longer, well-conserved C-terminal domain. A short stretch of that C-terminal domain, about 25 amino acids long, shows similarity to the C-terminal half of the domain described by Pfam model PF11776.10 (RcnB), but similarity between CigR and RcnB is not extensive.


:

Pssm-ID: 468512 [Multi-domain]  Cd Length: 147  Bit Score: 190.82  E-value: 3.64e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727184167  68 DDNLVSVSLSRDRARSLARNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKVVPYSMLRDLPQYPGYEWRIAGDDLVLVAL 147
Cdd:NF040487  54 DPDLVGPSISYGRARGLAVNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKAVPGRMLGQLPHYPGYEWRQAGTDLVLVAL 133

                         90
                 ....*....|....
gi 727184167 148 STAIVASVINGVFD 161
Cdd:NF040487 134 ATGIVYEVLNGVFD 147
 
Name Accession Description Interval E-value
T3SS_CigR_fam NF040487
anti-virulence regulator CigR family protein; Members of this family are full-length homologs ...
 68-161 3.64e-63

anti-virulence regulator CigR family protein; Members of this family are full-length homologs of CigR, an inner membrane protein that appears to act as an anti-virulence factor. It was previously thought to be exported as a type III secretion system (T3SS) effector. A low-complexity, variable length repetitive region, rich in Gly, Pro, His, Lys, and Asn, separates a short, hydrophobic N-terminal domain from a longer, well-conserved C-terminal domain. A short stretch of that C-terminal domain, about 25 amino acids long, shows similarity to the C-terminal half of the domain described by Pfam model PF11776.10 (RcnB), but similarity between CigR and RcnB is not extensive.


Pssm-ID: 468512 [Multi-domain]  Cd Length: 147  Bit Score: 190.82  E-value: 3.64e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727184167  68 DDNLVSVSLSRDRARSLARNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKVVPYSMLRDLPQYPGYEWRIAGDDLVLVAL 147
Cdd:NF040487  54 DPDLVGPSISYGRARGLAVNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKAVPGRMLGQLPHYPGYEWRQAGTDLVLVAL 133

                         90
                 ....*....|....
gi 727184167 148 STAIVASVINGVFD 161
Cdd:NF040487 134 ATGIVYEVLNGVFD 147
RcnB COG5455
Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];
78-158 1.29e-04

Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];


Pssm-ID: 444206 [Multi-domain]  Cd Length: 121  Bit Score: 39.32  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727184167  78 RDRARSLARNYGLTGYSSLPPGIAKNLARGKPLPPGIAKK---VVPYSmLRDLPQYP-GYEWRIAGDDLVLVALSTAIVA 153
Cdd:COG5455   37 RRDDRHDDPGHRDKHRGAGPGEDYKRWRRGDRLPPEYRGRryvVNDWR-RYGLPAPPrGYHWVRVGGDYVLVAIATGIIV 115


                 ....*
gi 727184167 154 SVING 158
Cdd:COG5455  116 SIVLG 120
 
Name Accession Description Interval E-value
T3SS_CigR_fam NF040487
anti-virulence regulator CigR family protein; Members of this family are full-length homologs ...
 68-161 3.64e-63

anti-virulence regulator CigR family protein; Members of this family are full-length homologs of CigR, an inner membrane protein that appears to act as an anti-virulence factor. It was previously thought to be exported as a type III secretion system (T3SS) effector. A low-complexity, variable length repetitive region, rich in Gly, Pro, His, Lys, and Asn, separates a short, hydrophobic N-terminal domain from a longer, well-conserved C-terminal domain. A short stretch of that C-terminal domain, about 25 amino acids long, shows similarity to the C-terminal half of the domain described by Pfam model PF11776.10 (RcnB), but similarity between CigR and RcnB is not extensive.


Pssm-ID: 468512 [Multi-domain]  Cd Length: 147  Bit Score: 190.82  E-value: 3.64e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727184167  68 DDNLVSVSLSRDRARSLARNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKVVPYSMLRDLPQYPGYEWRIAGDDLVLVAL 147
Cdd:NF040487  54 DPDLVGPSISYGRARGLAVNYGLTGYSSLPPGIAKNLARGKPLPPGIAKKAVPGRMLGQLPHYPGYEWRQAGTDLVLVAL 133

                         90
                 ....*....|....
gi 727184167 148 STAIVASVINGVFD 161
Cdd:NF040487 134 ATGIVYEVLNGVFD 147
RcnB COG5455
Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];
78-158 1.29e-04

Periplasmic regulator RcnB of Ni and Co efflux [Inorganic ion transport and metabolism];


Pssm-ID: 444206 [Multi-domain]  Cd Length: 121  Bit Score: 39.32  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727184167  78 RDRARSLARNYGLTGYSSLPPGIAKNLARGKPLPPGIAKK---VVPYSmLRDLPQYP-GYEWRIAGDDLVLVALSTAIVA 153
Cdd:COG5455   37 RRDDRHDDPGHRDKHRGAGPGEDYKRWRRGDRLPPEYRGRryvVNDWR-RYGLPAPPrGYHWVRVGGDYVLVAIATGIIV 115


                 ....*
gi 727184167 154 SVING 158
Cdd:COG5455  116 SIVLG 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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