|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
7-401 |
3.26e-55 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 188.13 E-value: 3.26e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 7 NSLWLMLERVSLSLSGIFVSVYVARYLGPAQYGLINYLLSVIAIAVPLVQLGADAVLFNRVAKRRRSGMRLMLASMRIRR 86
Cdd:cd13128 4 NSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYRKEKIREIISTSLVLK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 87 QLFALIALPLMA-WTLLTQDRTNQIMMLLMLISAYFSVQDVYKIYYD---ALLKSKLNTLINNVALLLSIVMRLGLVYAQ 162
Cdd:cd13128 84 LILGILALLLLFlFAFLIAFYDPELVLLLYILALSLPFSALNSLFRGifqGFEKMKYIVIARIIESVLSLILALILVLLG 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 163 LPLVWFALPYVLSSLLPYAVRWVLFRREQAQMPAISGRHKRRygRYLFSVGLPLAISSLSIVIYTRIDQIMLGNYLGEHS 242
Cdd:cd13128 164 GGLIGFALAYLIASVLSAILLLYIYRKKILLPKFFSFDLKLA--KELLRFSIPLALSGIFSLIYTRIDTIMLGYFLGDAA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 243 VGLYSAAITLSQGWVFVPIALIMSMMPGVANAGSEQEQEAR--IRQLYLMVLVLSMPVIAVLSLFPQQIVALMFGESYRQ 320
Cdd:cd13128 242 VGIYNAAYRIAELLLFIPSAISTALFPRISELYKNDKDELKklLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYLP 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 321 TATILALCSVTSLFSVMGTVSYRAIVLFSGYRFIAIKMPLAALANVVMNFILIPRYGIMGAAISTLITEFISFFVLNSFF 400
Cdd:cd13128 322 AALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLISEFIIFILLLYLL 401
|
.
gi 727180965 401 R 401
Cdd:cd13128 402 K 402
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
1-396 |
5.49e-38 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 141.24 E-value: 5.49e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 1 MKAMLMNSLWLMLERVSLSLSGIFVSVYVARYLGPAQYGLINYLLSVIAIAVPLVQLGADAVLFNRVAKRRRSGMRLMLA 80
Cdd:COG2244 1 LKKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEELRRLLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 81 SMRIRRQLFALIALPLMAW------TLLTQDRTNQIMMLLMLISAYFSVQDVYKIYYDALLKSKLNTLINNVALLLSIVM 154
Cdd:COG2244 81 TALLLRLLLSLLLALLLLLlapfiaALLGEPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 155 RLGLVYAQLPLVWFALPYvlssllpyavrwvlfrreqaqmpaisgrhkrrygrylfsvGLPLAISSLSIVIYTRIDQIML 234
Cdd:COG2244 161 ALLLALLGLGLWGLVLKY----------------------------------------SLPLLLSGLLGLLLTNLDRLLL 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 235 GNYLGEHSVGLYSAAITLSQGWVFVPIALIMSMMPGVANAGSEQEQEA---RIRQLYLMVLVLSMPVIAVLSLFPQQIVA 311
Cdd:COG2244 201 GALLGPAAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREElrrLYRKALRLLLLLGLPLALGLALLAPPLLS 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 312 LMFGESYRQTATILALCSVTSLFSVMGTVSYRAIVLFSGYRFIAIKMPLAALANVVMNFILIPRYGIMGAAISTLITEFI 391
Cdd:COG2244 281 LLFGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLV 360
|
....*
gi 727180965 392 SFFVL 396
Cdd:COG2244 361 LLLLL 365
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
7-396 |
9.29e-20 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 90.62 E-value: 9.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 7 NSLWLMLERVSLSLSGIFVSVYVARYLGPAQYGLINYLLSVIAIAVPLVQLGADAVLFNR--VAKRRRS---GMRLMLAS 81
Cdd:cd13127 4 GAFWSAISQVVVQLLQFVVTIILARLLTPEDFGLVAMATVFIAFAQLFSDLGLSSALIQRkdLTEEDLStvfWLNLLLGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 82 MrirrqLFALIAL--PLMAWtLLTQDRTNQIMMLLMLISAYFSVQDVYKIYYDALLKSKLNTLINNVALLLSIVMRLGLV 159
Cdd:cd13127 84 L-----LYLLLFLlaPLIAA-FYNEPELIPLLRVLSLSFLLSGLGSVPRALLQRELRFKKLAIIELISTLVSGVVAIVLA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 160 YAQLPLVWFALPYVLSSLLPYAVRWVLFRreqaqmPAISGRHKRRYGRYLFSVGLPLAISSLSIVIYTRIDQIMLGNYLG 239
Cdd:cd13127 158 LLGFGVWALVAQQLVGALVSTVLLWILSR------WRPRLSFSLASLKELLSFGSKLLGSNLLNYFSRNLDNLIIGKFLG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 240 EHSVGLYSAAITLSQgwvfVPIALIMSMMPGVANAG--SEQEQEARIRQLYL----MVLVLSMPVIAVLSLFPQQIVALM 313
Cdd:cd13127 232 AAALGYYSRAYRLAL----LPVQNITGPITRVLFPAlsRLQDDPERLRRAYLkalrLLALITFPLMVGLALLAEPLVLLL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 314 FGESYRQTATILALCSVTSLFSVMGTVSYrAIVLFSGYRFIAIKMPLAALANVVMNFILIPRYGIMGAAISTLITEFISF 393
Cdd:cd13127 308 LGEKWLPAVPILQILALAGLFQPLSSLNG-SLLLALGRTDLLLKLGLIKAVLTVLALLIGIPYGIIGVAIAYVIASLLSF 386
|
...
gi 727180965 394 FVL 396
Cdd:cd13127 387 PLN 389
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
7-254 |
2.11e-12 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 66.94 E-value: 2.11e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 7 NSLWLMLERVSLSLSGIFVSVYVARYLGPAQYGLINYLLSVIAIAVPLVQLGADAVLFNRVAKRRRSGMR-----LMLAS 81
Cdd:pfam01943 4 NVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAALVREIAKYREKYELvslywLNALL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 82 MRIRRQLFALIALPLMAWTLLTQDRTNQIMMLLMLISAYFSVQdVYKIYYDALLKSKLNTLINNVALLLSIVMRLGLVYA 161
Cdd:pfam01943 84 VKLVLVLLFLLLPLIAAFLGLPELAVLYRILALMFLLLPGVVQ-FRRGLFQGLERMKYALISQIVESLSRVILVFIAVFL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 162 QLPLVWFALPYVLSSLLPYAVRWVLFRREQAQMPAISgrhKRRYGRYLFSVGLPLAISSLSIVIYTRIDQIMLGNYLGEH 241
Cdd:pfam01943 163 PGDIVAALLYQVLAALVGGIIALAVLRKIFRPRFVFP---SLKLVRKLLSFGAPLFISSLAISLYTYIDSILLGLLLGAG 239
|
250
....*....|...
gi 727180965 242 SVGLYSAAITLSQ 254
Cdd:pfam01943 240 AVGIYNAAYQLLV 252
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
146-400 |
2.65e-12 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 68.26 E-value: 2.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 146 VALLLSIVMRLGLVYAQLPLVWFALPYVLSSLLPYAVRWVLFRREQAQMPAISGRHK----RRYGRYLFSVGLPLAISSL 221
Cdd:COG5841 168 ILLLAYLLLPYGLEYAAAGATFGAVIGALAGLLVLLYYYRKRKKKLKRLLEKSKTKSkessKDILKELLRIAIPITLSSL 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 222 SIVIYTRIDQIMLGNYLGEHSV---------GLYSA-AITLSQGWVFVPIALIMSMMPGVANAGSEQEQEA---RIRQLY 288
Cdd:COG5841 248 VLPLFQLIDSFTVPRRLQAAGLsaseatslyGILSGmAQPLVNLPTVLATALATSLVPAISEAFAKKDRKLvrrRINQAL 327
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 289 LMVLVLSMPVIAVLSLFPQQIVALMFGESyrQTATILALCSVTSLFSVMGTVSYrAIVLFSGYRFIAIK-MPLAALANVV 367
Cdd:COG5841 328 RLTLLIGLPAAVGLAVLAEPINTLLFGNP--EGGGILAILAPSAIFLSLQQVTT-GILQGLGKQKIPVInLLIGLLVKII 404
|
250 260 270
....*....|....*....|....*....|...
gi 727180965 368 MNFILIPRYGIMGAAISTLITEFISfFVLNSFF 400
Cdd:COG5841 405 LNYLLVPLFGIYGAALATVIGYLVA-AILNLAA 436
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
174-387 |
3.87e-11 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 64.41 E-value: 3.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 174 LSSLLPYAVRWVLFRREQAQMPAISGRHKRRYGRY---LFSVGLPLAISSLSIVIYTRIDQIMLGNYLGEHSVGLYSA-- 248
Cdd:cd13124 188 LAGLLVLLYYYRKKRRELKRLLRKSPRSKISTKEIlkeLLSYAIPITLSSLILPLLQLIDSFTVPRRLQAAGLSESEAta 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 249 --------AITLSQGWVFVPIALIMSMMPGVANAGSEQEQEA---RIRQLYLMVLVLSMPVIAVLSLFPQQIVALMFGES 317
Cdd:cd13124 268 lygiltgrAQPLVQLPTVIATALSTSLVPAISEAYAKGDKKElrrRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDS 347
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180965 318 yrQTATILALCSVTSLFSVMGTVSyrAIVLFSG--YRFIAIKMPLAALANVVMNFILIPRYGIMGAAISTLI 387
Cdd:cd13124 348 --EGGLILQILAPSILFLSLQQVT--AAILQGLgkVKIPVINLLIGLLVKIVLNYVLIPIFGIYGAAIATVI 415
|
|
| MATE_epsE_like |
cd13129 |
Multidrug and toxic compound extrusion family and similar proteins; This model represents a ... |
5-392 |
3.26e-10 |
|
Multidrug and toxic compound extrusion family and similar proteins; This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins, including Ralstonia solanaceraum GMI1000 epsE, which may be involved in exporting exopolysaccharide EPS I, a virulence factor. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240534 [Multi-domain] Cd Length: 411 Bit Score: 61.74 E-value: 3.26e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 5 LMNSLWLMLERVSLSLSGIFVSVYVARYLGPAQYGLINYLLSVIAIAVPLVQLGADAV------LFNRVAKRRRSGMRLM 78
Cdd:cd13129 3 ASGSFWSLGGLVASRGAVFLTNIMVARSLGKHVFGEFGVIQVTIGLLGTFAGFGLGLAatkviaETKDVDPERAGRIIGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 79 LASMRIRRQLFALIALPLMAWTLLTQDRTN-------QIMMLLMLISAYFSVQDVYKIYYDALLKSKLNTLIN---NVAL 148
Cdd:cd13129 83 SILLAVVTGALAATVLFLSATWIAIATLNAphlaellRIAAIILILTAFTGAQTGFLSGFEAFRAIARVNIWAgllLLPL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 149 LLSIVMRLGLVYAQLPLVWFALPYVLSSLLpyavrwVLFRREQAQMPAISGRHKRRYGRYLFSVGLPLAISSLSIVIYTR 228
Cdd:cd13129 163 MWIGVYIRGLVGAVVILLASAAGNVASNSL------ILRRECQNQRGPVRTGLTWQELRVLFKFSLPSVLSGSMGSPVHW 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 229 IDQIMLGNY-LGEHSVGLYSAAITLSQGWVFVPIALIMSMMPGVANA--GSEQEQEARIRQLYLMVLVLSMPVIAVLSLF 305
Cdd:cd13129 237 IALAILVNQpNGYAELGLFNAANQWRQFITFLPATLGNVALPFLAENfgNNEGMFRQTFRSALLFGLGLSLPLGCVFILA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 306 PqQIVALMFGESYRQTATILALCSVTSLFSVMG-TVSYRAIVLFSGYRFIAIKMpLAALANVVMNFILIPRYGIMGAAIS 384
Cdd:cd13129 317 S-QIFAWLYGKEYGSAAASMRSLAVAAILVGLSvLLGQIIASSGKIWRGFALNM-VWSVIYVAAAYLLLRLYGAPGLALA 394
|
....*...
gi 727180965 385 TLITEFIS 392
Cdd:cd13129 395 MSAAYCVL 402
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
202-404 |
3.56e-10 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 61.31 E-value: 3.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 202 KRRYGRYLFSVGLPLAISSLSIVIYTRIDQIMLGNyLGEHSVglysAAITLSQGWVFVPIALIMSMMPGVAN-------A 274
Cdd:COG0534 3 EGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGR-LGTAAL----AAVGLAFPIFFLLIALGIGLGVGGTAlvaqalgA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 275 GSEQEQEARIRQLYLMVLVLSMPVIAVLSLFPQQIVALMF--GESYRQTATILALCSVTSLFSVMGTVsYRAIVLFSGY- 351
Cdd:COG0534 78 GDREEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGadPEVLALARDYLRIILLGLPFLLLFNV-LNGILRGLGDt 156
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 727180965 352 RFIAIKMPLAALANVVMNFILI--PRYGIMGAAISTLITEFISFFVLNSFFRGGK 404
Cdd:COG0534 157 KTPMIIMLIGNVLNIVLDPLLIfgGGLGVAGAALATVISQAVSALLLLYYLFRKR 211
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
206-423 |
4.98e-09 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 57.91 E-value: 4.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 206 GRYLFSVGLPLAISSLSIVIYTRIDQIMLGNYLGEHSVglysAAITLSqgwvfVPIALIM---SMMPGVANA-------G 275
Cdd:cd13143 3 GKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGVGALAL----AAVNLV-----FPIIMLLmalGLMIGVGGAslisrrlG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 276 SEQEQEAR--IRQLYLMVLVLSMPVIAVLSLFPQQIVALM--FGESYRQTATILALCSVTSLFSVMGTVSYRAIVLFSGY 351
Cdd:cd13143 74 AGDREKANriFSTALLLSLILGLLLTILGLLFLDPLLRLLgaSGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKP 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727180965 352 RFIAIKMPLAALANVVMN--FILIPRYGIMGAAISTLITEFISFFVLNS-FFRGGKITRLQVTCYRCFPQLIGKV 423
Cdd:cd13143 154 KLAMLGMLIGAVLNIILDplFIFVLGLGIAGAALATVIAQLISLLLLLLyFFRGKSLLKLSLLRFKLSLKIIKEI 228
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
207-404 |
5.97e-09 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 57.52 E-value: 5.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 207 RYLFSVGLPLAISSLSIVIYTRIDQIMLGNyLGEHSVglysAAITLSQGWVFVPIALIMSMMPG----VANA-GSEQEQE 281
Cdd:cd13137 1 RRIWSLAWPVILENLLQTLVGLVDVFMVGR-LGAEAI----AAVGLATQVLWLLLVLNMALGTGtvalVSQSyGAGDYER 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 282 AR--IRQLYLMVLVLSMPVIAVLSLFPQQIVALMF--GESYRQTATILALCSVTSLFSVMGTVSYRAIVLFSGYRFIAIK 357
Cdd:cd13137 76 ARraLGQSLLLALLLSLPLALLGLLFAEPLLRLLGadPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYI 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 727180965 358 MPLAALANVVMNFILI------PRYGIMGAAISTLITEFISFFVLNSFFRGGK 404
Cdd:cd13137 156 MIIVNVLNIVLDYVLIfglwgfPGLGVAGAALATVISRVVGALLLLFLLLRGR 208
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
20-401 |
2.00e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 56.01 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 20 LSGIFVSVYVARYLGPAQYGLINYLLSVIAIAVPLVQLG----------ADAVLFNRVAKRRRSGMRLMLASMRIRRQLF 89
Cdd:cd13125 15 LAGLIINKVVAVYLGPSGVALLGQLQNFVTILQTIAGGGinngvvkytaEYKDDEEKLARVWSTAFRITLILSILGGLLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 90 ALIALPLMAWTLLTQDRTNQIMMLLMLISAyFSVQDVYKIYYDALLKSKLNTLINNVALLLSIVMRLGLVYaQLPLVWFA 169
Cdd:cd13125 95 LLFSKPLSSLLFGDIDYSWVFILLGLALPL-FALNNLLLAILNGLKEIKRYALINIISSLIGLLVSVLLVY-FYGLKGAL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 170 LPYVLSSLLPYAVRWVLFRREQ-AQMPAISGRHKRRYGRYLFSVGLPLAISSLSIVIYTRIDQIMLGNYLGEHSVGLYSA 248
Cdd:cd13125 173 LALVLNQSLIFLVTLIYSRKQPwFKLKYLWGRLDKDIIKKLLKFSLMALVSALSLPLSQIIVRNILIRQLGWEAAGYWQA 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 249 AITLSQGWV-FVPIALIMSMMPGVANAGSEQEQEARIRQLYLMVLVLSMPVIAVLSLFPQQIVALMFGESYRQTATILAL 327
Cdd:cd13125 253 VWKISDVYLgFITTALSTYYLPRLSAIKDNKELKREVNKQLKVILPLVAIGALLIYLLRDLIIQILFSEEFLPARELFLW 332
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727180965 328 CSVTSLFSVMG-TVSYraIVLFSGYRFIAIKMPLA-ALANVVMNFILIPRYGIMGAAISTLITEFISFFVLNSFFR 401
Cdd:cd13125 333 QLIGDFFKIASwLLGY--ILLAKGMTKLFIITEILfALLFVLLSLLFIPLFGLEGAGIAYAINYILYLILMYFIFR 406
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
207-396 |
3.47e-08 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 55.16 E-value: 3.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 207 RYLFSVGLPLAISSLSIVIYTRIDQIMLGNYLGEHSVglysAAITLSQGWVFVPIALIMSMMPGVAN-------AGSEQE 279
Cdd:cd13138 3 KTLLLFALPLLLSNLLQQLYNLVDLLIVGQFLGVAAL----AAVSNGSPIIFLLTAIGMGLSMGGTIlisqyigAKDEEK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 280 QEARIRQLYLMVLVLSMPVIAVLSLFPQQIVALMF--GESYRQTATILALCSVTSLFSVMGTVsYRAIvlFSGY---RFI 354
Cdd:cd13138 79 AKKAVGTLLVLFLILGIVLTILGLLFAPPILRLMNtpAEILELAVSYLRICFLGIPFIFGYNA-YSAI--LRGLgdsKTP 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 727180965 355 AIKMPLAALANVVMNFILI--PRYGIMGAAISTLITEFISFFVL 396
Cdd:cd13138 156 LYFVIIACVLNIILDLLFIavFHMGVAGAALATVIAQAISVLLA 199
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
207-396 |
1.11e-07 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 53.66 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 207 RYLFSVGLPLAISSLSIVIYTRIDQIMLGNY----LGEHSVG--LYSAAITLSQGwvfvpiaLIMSMMPGVANA-GSEQE 279
Cdd:cd13131 3 RALLRLALPILIAQLAQMAMGFVDTVMAGRLgaddLAAVALGssLWFPVFTFGMG-------LLLAVTPLVAQAhGAGDR 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 280 QEAR--IRQLYLMVLVLSMPVIAVLSLFPQQIVALMFGESYRQTATILALCSVTSLFSVMGTVSYRAIVLFSGY-RFIAI 356
Cdd:cd13131 76 RRIRraVRQGLWLALLLSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRtRPAMV 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 727180965 357 KMPLAALANVVMNFILI------PRYGIMGAAISTLITEFISFFVL 396
Cdd:cd13131 156 ITLLALVLNIPLNYVLIfgkfglPALGGAGAGLATAIVYWLMFLAL 201
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
29-318 |
2.28e-07 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 52.21 E-value: 2.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 29 VARYLGPAQYGLINYLLSVIAIAVPLVQLGADAVLF---NRVAKRRRSGMRLMLASMRIRRQLFALIAlPLMAWtLLTQD 105
Cdd:pfam13440 2 LARLLSPEDFGVVAIATVVISFANIFVDMGFSSALIqkkDITETDYSTVFTFNLIFGALIYLILFALA-PLIAS-FYNQP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 106 RTN---QIMMLLMLISAYFSVQDVY---KIYYDALLKSKLntlinnVALLLSIVMRLGLVYAqLPLVWfALpyVLSSLLP 179
Cdd:pfam13440 80 ELVpvlRVLALVLILNGLSSVQTALlrrDLRFKKLFKITL------TSSVIGGIVGIVLAYL-GFGVW-AL--VIGTLAQ 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 180 YAVRWVLFRREQAQMPAISGRhkRRYGRYLFSVGLPLAISSLSIVIYTRIDQIMLGNYLGEHSVGLYSaaitLSQGWVFV 259
Cdd:pfam13440 150 QLLSLVLLWLASDWRPRLTFS--LKVIKELFSFGSWLLLSNLLNYLARNLDNLIIGKVLGTAALGLYS----VAYRLALL 223
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180965 260 PIALIMS-----MMPGVANAgseQEQEARIRQLYLMVL----VLSMPVIAVLSLFPQQIVALMFGESY 318
Cdd:pfam13440 224 PTANITSvitkvLFPALSRI---QDDKAKLRELYLRVLrliaFIVFPIMAGLAVVAEPLVLVLLGSQW 288
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
207-406 |
7.17e-07 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 51.04 E-value: 7.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 207 RYLFSVGLPLAISSLSIVIYTRIDQIMLGNyLGEHSVglysAAITLSQGWVFvpiaLIMSMMPGVANAGS---------E 277
Cdd:cd13142 11 RTLLKLAWPIIVSNLLQVAYNLADTFWLGR-LGADAV----AAPSISWPLIF----LFISLGGGLTVAGTalvaqytgaG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 278 QEQEAR--IRQLYLMVLVLSMPVIAVLSLFPQQIVALMFG---ESYRQTATILALCSVTSLFSVmGTVSYRAivLFSGY- 351
Cdd:cd13142 82 DYDKANkvAGQTFSFVIILSLILAVLGYILSRPLLLLLIGapeEVYPLALAYLRIIFLGLPFMF-IFFVFNS--LLRGIg 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180965 352 --RFIAIKMPLAALANVVMNFILI------PRYGIMGAAISTLITEF----ISFFVLNSFFRGGKIT 406
Cdd:cd13142 159 dtKTPMKIMFGSVLLNVILDPLLIfgigpfPGLGVAGAALATVISRGiaavIGLYLLFKGRVGLKIS 225
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
141-396 |
9.76e-07 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 50.53 E-value: 9.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 141 TLINNVALLLSIVmrLGLVYAQLPLVWFALPYVLSSLLPYAVRWVLFRREQAQM-PAISGRHKRRygRYLFSVGLPLAIS 219
Cdd:cd13123 152 PVLLNLVIIAGLL--LLAPLFDLGIYALAWGVLLGGVLQLLVQLPALRRLGFRFrPRLDFRDPGV--RRVLKLMLPALLG 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 220 SLSIVIYTRIDQImLGNYLGEHSVGLYSAAITLSQ---GwVFVpIALIMSMMPGVANAGSEQEQEARIRQLYL---MVLV 293
Cdd:cd13123 228 VSVSQINLLVDTI-LASFLPEGSISALYYADRLYQlplG-IFG-VAIATALLPRLSRLAAAGDLDEFRRTLSRglrLVLF 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 294 LSMPVIAVLSLFPQQIVALMFG------ESYRQTATILALCSVTSLFSVMGTVSYRAivlfsgyrFIAIKMP-------- 359
Cdd:cd13123 305 LLLPAAVGLIVLAEPIVRLLFErgaftaEDTLMTASALAAYALGLPAFALVKLLSRA--------FYALKDTktpvkiav 376
|
250 260 270
....*....|....*....|....*....|....*..
gi 727180965 360 LAALANVVMNFILIPRYGIMGAAISTLITEFISFFVL 396
Cdd:cd13123 377 IAVAVNILLNLLLIKPLGHVGLALATSLSAWVNALLL 413
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
207-407 |
1.15e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 50.60 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 207 RYLFSVGLPLAISSLSIVIYTRIDQIMLGNYlGEHSVglysAAITLSQGWVFVPIALIMSMMPGVA-----NAGSEQEQE 281
Cdd:cd13133 5 REILKIALPLVLSMLSQTVMGFTDRAFLGRL-SEVAL----AASGPAGVLYFAILMLFFGLSSGVQvfvaqYNGAGRYSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 282 -ARIRQLYLMVLVLSMPVIAVLSLFPQQIVALMFGES---YRQTATILALCSVTSLFSVMGTVsyraivlFSGYrFIAIK 357
Cdd:cd13133 80 iGRVLWQGLYFSLLLAPLLALLSALAAPLLFLLLGHSpevQALEVEYFRIRILGAPFSLLGAA-------LRAF-FSGIG 151
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727180965 358 MP--------LAALANVVMNFILI------PRYGIMGAAISTLITEFISFFVLNSFFRGGKITR 407
Cdd:cd13133 152 RTrvvmvanlVMVVVNIVLDYALIfgklgfPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRR 215
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
142-396 |
3.35e-06 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 48.99 E-value: 3.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 142 LINNVALLLSIVmrLGLVYAQLPLVWFALPYVLSSLLPYAVRWVLFRREQAQ-MPAISGRHKrrYGRYLFSVGLPLAISS 220
Cdd:COG0728 160 VLLNLVIIAGLL--LLAPLFGPGIYALAWGVLLGGVLQLLIQLPALRRLGLRlRPRFDLRDP--GVRRVLKLMLPALLGV 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 221 LSIVIYTRIDQImLGNYLGEHSVGLYSAAITLSQgwvfVPIALI-----MSMMPGVANAGSEQEQEA---RIRQLYLMVL 292
Cdd:COG0728 236 SVSQINLLVDTI-LASFLPEGSVSALYYADRLYQ----LPLGLFgvaigTALLPRLSRAAAAGDLEEfrrTLSRGLRLVL 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 293 VLSMPVIAVLSLFPQQIVALMFG------ESYRQTATILALCSVTSLFSVMGTVSYRAIVLFSGYRFIAIKMPLAALANV 366
Cdd:COG0728 311 LLTLPAAVGLIVLAEPIVRLLFErgaftaEDTALTALALAAYALGLPAFALVKVLARAFYARQDTRTPVRIAVIAVVVNI 390
|
250 260 270
....*....|....*....|....*....|
gi 727180965 367 VMNFILIPRYGIMGAAISTLITEFISFFVL 396
Cdd:COG0728 391 VLNLLLVPPLGHAGLALATSLSALVNALLL 420
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
214-405 |
7.64e-06 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 47.70 E-value: 7.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 214 LPLAISSLSIVIYTRIDQIMLGNYLGEhSVGLYSAAITLSQGWVFVPIALIMSMMPGVANA-GSEQEQEAR--IRQLYLM 290
Cdd:cd12082 2 APLLLSMLLQTLYNLVDTFFLGRLLGD-ALAAVGLAFPLIALLIALGVGLSVGTSALISQAiGAGDEEKARrvLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 291 VLVLSMPVIAVLSLFPQQIVALMF--GESYRQTATILALCSVTSLFSVMGTVSYRAIVLFSGYRFIAIKMPLAALANVVM 368
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGaeEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 727180965 369 NFILI-----PRYGIMGAAISTLITEFISFFVLNSFFRGGKI 405
Cdd:cd12082 161 DPLLIfglgpPELGIAGAALATVISYVIGALLLLIYLRKGKK 202
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
110-401 |
2.30e-04 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 43.08 E-value: 2.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 110 IMMLLMLIsayFSVQDVYKIYYDALLKSKLNTLINNVALLLSIVMRLGLVYAQLPLVWFALPYVLSSLLPYAV-----RW 184
Cdd:cd12082 119 ILILGLPI---TFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDPLLIFGLGPPELGIAGAALATVISYVIgalllLI 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 185 VLFRREQAQMPAISGRH-KRRYGRYLFSVGLPLAISSLSIVIYTRIDQIMLGNYLGEHSVGLYSAAITLSQGWVFVPIAL 263
Cdd:cd12082 196 YLRKGKKILKFKLSLLKpDLELLRRLLRIGLPSAIQNSLLSLGLLIIVAIVAAFGGAAALAAYTVAFRIASLAFMPALGL 275
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 264 IMSMMPGVA-NAGSEQEQEARIRQLYLMVLVLSMPVI--AVLSLFPQQIVALmfgesYRQTATILALcSVTSLFSVMGTV 340
Cdd:cd12082 276 AQAALPVVGqNLGAGNFDRARRITWVALLIGLLIGAVlgLLILLFPEPILSL-----FTNDPEFLEL-AVSYLRILAIYY 349
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180965 341 SYRAIVLFSGYRFIAIK---------MPLAALANVVMNFILIPR-YGIMGAAISTLITEFISFFVLNSFFR 401
Cdd:cd12082 350 LFVGIGYVLQAGFQAAGrtlkslivsLLSYWVVRLPLAYVLAYLgLGLYGIWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
209-396 |
3.02e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 42.87 E-value: 3.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 209 LFSVGLPLAISSLSIVIYTRIDQIMLGnYLGEHSVglysAAITLSQGWVFVPIALIMSMMPGVA-----NAGSEQEQEAR 283
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLS-RYSDNAV----AAVGVANQILFLLILIFSFISTGTSiliaqYLGAKDKKKAR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 284 --IRQLYLMVLVLSMPVIAVLSLFPQQIVALMF--GESYRQTATILALCSVTSLFSVMGTVsYRAIVLFSGY-RFIAIKM 358
Cdd:cd13134 80 qiAGVALLFNLLLGLVFSLLLLFFGAELLRLMGlpPELLALGSTYLRIVGGSLFLQALSLT-LSAILRSHGRtKIPMYVS 158
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 727180965 359 PLAALANVVMNFILI------PRYGIMGAAISTLITEFISFFVL 396
Cdd:cd13134 159 LIMNILNIVGNYLLIfgwfglPKLGVAGVAISTVISRAVGLVLL 202
|
|
| PRK10459 |
PRK10459 |
MOP flippase family protein; |
10-338 |
3.24e-04 |
|
MOP flippase family protein;
Pssm-ID: 236697 [Multi-domain] Cd Length: 492 Bit Score: 42.71 E-value: 3.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 10 WLMLERVSLSLSGIFVSVYVARYLGPAQYGLINYLLSVIAIAVPLVQLGADAVLFNRVAKRRRSGMRLMLASMRIRRQLF 89
Cdd:PRK10459 13 WTAISTVIIIGLQLVQLTVLARILDNHQFGLLTMSLVIIGFADTLSDMGIGASIIQRQDISHLQLSTLYWLNVGLGIVVF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 90 ALIAL--PLMAwTLLTQDRTNQIMMLLMLISAYFSVQDVYKIYYDALLKSKLNTLINNVALLLSIVMRLGLVYAQLPLVW 167
Cdd:PRK10459 93 VLVFLlsPLIA-DFYHNPELAPLIKTLSLAFVIIPIGQQFRALLQKELEFNKLAKIEISAVVAGFTFAVVSAFFWPGALA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 168 FALPYVLSSLLPYAVRWVLFRREQAQMPAISGRHKRRYgrylFSVGLPLAISSLSIVIYTRIDQIMLGNYLGEHSVGLYS 247
Cdd:PRK10459 172 AILGYLVNSSVRTLLFGYFGRKIYRPALHFSLASVKPN----LSFGAWQTAERIINYLNTNIDTILIGRILGAEVLGGYN 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 248 AAITLsqgwVFVPIALIMSMMPGVANA--GSEQEQEARIRQLYL----MVLVLSMPVIAVLSLFPQQIVALMFGESYRQT 321
Cdd:PRK10459 248 LAYNV----ATVPPMKINPIITRVAFPvfAKIQDDTEKLRVGFLkllsVLGIINFPLLLGLMVVSNNFVPLVFGEKWNSA 323
|
330
....*....|....*..
gi 727180965 322 ATILALCSVTSLFSVMG 338
Cdd:PRK10459 324 IPILQLLCIVGLLRSVG 340
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
215-371 |
4.29e-04 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 40.63 E-value: 4.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 215 PLAISSLSIVIYTRIDQIMLGnYLGEHSVGLYSAAITLSQGWVFVPIALIMSMMPGVANA-GSEQEQEAR--IRQLYLMV 291
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVG-HLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQAlGAGNFKRAGvaLRQGLILG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 292 LVLSMPVIAVLSLFPQQIVALMfgesyRQTATILALCSVTSLFSVMGTVSYRAIVLFSGY-------RFIAIKMPLAALA 364
Cdd:pfam01554 80 LLLSLPIALLVLLFSEPILSLF-----GQDEEVLALAKRYLRILILGIPFYALQFVLSGFlrgqgdtKPPMYINIISLLL 154
|
....*..
gi 727180965 365 NVVMNFI 371
Cdd:pfam01554 155 NIPLNYL 161
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
180-396 |
4.31e-04 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 42.44 E-value: 4.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 180 YAVRWVLFRREQAQMPAISGRHKRRYGRYLFSVGLPLAISSLSIVIYTRIDQIMLGNYlGEHSVGLYSAAITLSQGWVFV 259
Cdd:COG0534 202 LLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQLAESLGFLVLNALVARL-GTAAVAAYGIALRIESLAFMP 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 260 PIALIMSMMPGVA-NAGSEQEQEAR--IRQLYLMVLVLSMPVIAVLSLFPQQIVALMFG--ESYRQTATILALCSVTSLF 334
Cdd:COG0534 281 ALGLGQAAQPLVGqNLGAGDYDRARraARLALLLALGIGLLLALLLFLFPEPIIGLFTDdpEVIALAATYLRIAALFQPF 360
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727180965 335 SVMGTVSY---------RAIVLFSGYRFIAIKMPLAALANvvmnfilIPRYGIMGAAISTLITEFISFFVL 396
Cdd:COG0534 361 DGLQFVLSgalrgagdtRFPMIISLLRLWLVRLPLAYLLA-------FLGLGLTGVWLALPIGEVLRALLL 424
|
|
| MATE_like_11 |
cd13126 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
8-341 |
4.59e-04 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240531 [Multi-domain] Cd Length: 396 Bit Score: 42.29 E-value: 4.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 8 SLWLMLERVSLSLSGIFVSVYVARYLGPAQYGLINYLLSVIAIAVPLVQLGADAVLFNRVAKRRRSGMRLMLASMRIRRQ 87
Cdd:cd13126 1 ALWTLADQALSSLTNFALGVLVARSLGPEAFGAFSLAFTVFGVAVGVSRALVTAPLGIRYSAVDAAAFRRAVRKATGTAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 88 LFALIA-LPLMAWTLLTQDRTNQIMMLLMLISAYFSVQDVYKIYYDALLKSKLNTLINNVALLLsivmRLGLVYAQLPLV 166
Cdd:cd13126 81 AVGLALgLVTALVGALLGGTVGSPLVALGVVLPGLLLQDAWRGAFFAQGRPGRAAANDLVWAVA----QLAGAMLIVALV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 167 WFALPYVLSSLLPYAVRWVLFRREQAQMPAISG-RHKRRYGRYLFsvGLPLAI-SSLSIVIYTRIdqIMLGNYLGEHSVG 244
Cdd:cd13126 157 SGVAAALLAWGASAVVAALLGRAQAGLWPRPRGaLAWLREHRDLT--GYLLAEfVLGQGAAQNSD--LLLGALGSLAAVG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 245 LYSAAITLSQGWVFVPIALIMSMMPGVANAgSEQEQEARIRQLYLM---VLVLSMPVIAVLSLFPQQIVALMFGESYRQT 321
Cdd:cd13126 233 ALRGAQTLLGPLTILAAGLVTAAVPELARR-KDMSPRRRRRAALVLsgvVAAAALVWGLALLLLPDLIGEALLGDVWAGA 311
|
330 340
....*....|....*....|
gi 727180965 322 ATILALCSVTSLFSVMGTVS 341
Cdd:cd13126 312 QALLLPLILAQAGAALAVGP 331
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
207-396 |
4.86e-04 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 42.17 E-value: 4.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 207 RYLFSVGLPLAISSLSIVIYTRIDQIMLGnylgeHSVGLYSAAITLSQGWVFVPIALIMSmmpGVANA---------GSE 277
Cdd:cd13132 3 KKLLRLAAPLVLTSLLQYSLSVVSVVFVG-----HLGKLELAAASLASSFANVTGFSILL---GLASAldtlcgqafGAK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 278 QEQE-ARIRQLYLMVLVLSMPVIAVLSLFPQQIVALMfgesyRQTATILALCSVTSLFSVMGTVSYraIVLFSGYRF--- 353
Cdd:cd13132 75 NYKLvGVYLQRALVILLLCCVPISLLWLNTEPILLLL-----GQDPEIARLAGEYLRWLIPGLFAY--ALFEPLKRYlqa 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 727180965 354 IAIKMPL------AALANVVMNFILI--PRYGIMGAAISTLITEFISFFVL 396
Cdd:cd13132 148 QGIVLPLvyislvALLLNILLNYLLVfvLGLGFIGAALATSISYWLIVVLL 198
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
324-396 |
4.93e-04 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 40.25 E-value: 4.93e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180965 324 ILALCSVTSLFSVMGTVSYRAIVLFSGYRFIAIKMPLAALANVVMNFILIPRYGIMGAAISTLITEFISFFVL 396
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLN 73
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
209-408 |
7.39e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 38.28 E-value: 7.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 209 LFSVGLPLAISSLSIVIYTRIDQIMLGnYLGEH---SVGLYSAAITLSQGWVFVPIaliMSMMPGVANA-GSEQEQEAR- 283
Cdd:cd13140 7 LLRLALPIMGTSFIQMAYNLTDMFWVG-RLGSDavaAVGTAGFFVWLAYALALLSK---IGAQVKVSQSiGAKDEKEARk 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 284 -IRQLYLMVLVLSMPVIAVLSLFPQQIVALM-FGESY--RQTATILALCSVTSLFSVMGTVsYRAIVLFSGYRFIAIKMP 359
Cdd:cd13140 83 yARNALQLNLLLGILYGLLLLLFAKPLIGFFnLGDAEviSLAITYLRIVALGLIFSFLNPV-FTGIFNALGDSKTPFIIN 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 727180965 360 LAALA-NVVMNFILI------PRYGIMGAAISTLITEFISFFVLnsFFRGGKITRL 408
Cdd:cd13140 162 AIGLVlNIILDPLLIfgfgpfPALGVAGAALATVLAQAIVFLLF--LYALKKKKGL 215
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
173-395 |
7.66e-03 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 38.26 E-value: 7.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 173 VLSSLLPYAVRWVLFRREQAQMPAISGRHK--RRYGRYLFSVGLPLAISSLSIVIYTRIDQIMLGNYLGEHSVGLYSAAI 250
Cdd:cd13143 190 VIAQLISLLLLLLYFFRGKSLLKLSLLRFKlsLKIIKEILALGFPSFLMQLSSSVVTIVLNLTLLGYGGDIGVAAFGIVT 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 251 TLSQGWVFVPIALIMSMMPGVA-NAGSEQEQeaRIRQLY----LMVLVLSMPVIAVLSLFPQQIVALMFGES--YRQTAT 323
Cdd:cd13143 270 RILTFLFLPLIGLSQGLQPIIGyNYGAGNYD--RVKQALklalIVALIYGLVLFLILLLFPEQIVSLFTDDPelIALAAR 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180965 324 ILALCSVTSLFSvmgtvsyrAIVLFSGYRFIAIKMP-LAALANVVMNFILI-------PRY-GIMGAAISTLITEFISFF 394
Cdd:cd13143 348 ILRIFLLAFPLA--------GINIVLSGYFQAIGKAkRAALLSLLRQGLFLiplllilPRLfGLDGIWLAFPLAEILTLL 419
|
.
gi 727180965 395 V 395
Cdd:cd13143 420 L 420
|
|
| |
