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Conserved domains on  [gi|727180963|ref|WP_033643435|]
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MULTISPECIES: glycosyltransferase family A protein [Serratia]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11421525)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  16037492|18518825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-193 2.65e-17

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 78.59  E-value: 2.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   1 MDLSIVIPAFNNSNHLAATLARMTHYcAGFDYEIIVVDYSSEAGESEKIHGLLAANHRARLHESRVRGNIAVACNIGFRL 80
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQ-TYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963  81 ARSEVVFFLEPEDMFGTNYIIRRLRRHEDTRIDIVFGNYT----TVNDKNVRSYVFNYQEgvagedfLFIEMGDIRTSTI 156
Cdd:COG0463   81 ARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLiregESDLRRLGSRLFNLVR-------LLTNLPDSTSGFR 153

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 727180963 157 SVRKKQDRRFLFPEflARYQDWGFLvNATNLGARVVH 193
Cdd:COG0463  154 LFRREVLEELGFDE--GFLEDTELL-RALRHGFRIAE 187
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-193 2.65e-17

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 78.59  E-value: 2.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   1 MDLSIVIPAFNNSNHLAATLARMTHYcAGFDYEIIVVDYSSEAGESEKIHGLLAANHRARLHESRVRGNIAVACNIGFRL 80
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQ-TYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963  81 ARSEVVFFLEPEDMFGTNYIIRRLRRHEDTRIDIVFGNYT----TVNDKNVRSYVFNYQEgvagedfLFIEMGDIRTSTI 156
Cdd:COG0463   81 ARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLiregESDLRRLGSRLFNLVR-------LLTNLPDSTSGFR 153

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 727180963 157 SVRKKQDRRFLFPEflARYQDWGFLvNATNLGARVVH 193
Cdd:COG0463  154 LFRREVLEELGFDE--GFLEDTELL-RALRHGFRIAE 187
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-146 1.39e-10

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 58.67  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   5 IVIPAFNNSNHLAATLARMTH--YCagfDYEIIVVDYSSEAGESEKIHGLLAANHRARLHESRVRGNIAVACNIGFRLAR 82
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAqtYP---NFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAAR 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180963  83 SEVVFFLEPEDMFGTNYIIRRLRR-HEDTRIDIVFGNYTTVNDKNVRSYVFNYQE--GVAGEDFLFI 146
Cdd:cd00761   78 GEYILFLDADDLLLPDWLERLVAElLADPEADAVGGPGNLLFRRELLEEIGGFDEalLSGEEDDDFL 144
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-128 2.07e-10

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 58.56  E-value: 2.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963    4 SIVIPAFNNSNHLAATLARMTHYCaGFDYEIIVVDYSSEAGESEKIHGLLAANHRARLHESRVRGNIAVACNIGFRLARS 83
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQT-YPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 727180963   84 EVVFFLEPEDMFGTNYIIRRLRRHEDTRIDIVFGNYTTVNDKNVR 128
Cdd:pfam00535  80 DYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGE 124
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 1-38 1.39e-03

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 39.75  E-value: 1.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 727180963   1 MDLSIVIPAFNNSNHLAATLARMTHYCAG-------FDYEIIVVD 38
Cdd:PTZ00260  70 VDLSIVIPAYNEEDRLPKMLKETIKYLESrsrkdpkFKYEIIIVN 114
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-193 2.65e-17

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 78.59  E-value: 2.65e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   1 MDLSIVIPAFNNSNHLAATLARMTHYcAGFDYEIIVVDYSSEAGESEKIHGLLAANHRARLHESRVRGNIAVACNIGFRL 80
Cdd:COG0463    2 PLVSVVIPTYNEEEYLEEALESLLAQ-TYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963  81 ARSEVVFFLEPEDMFGTNYIIRRLRRHEDTRIDIVFGNYT----TVNDKNVRSYVFNYQEgvagedfLFIEMGDIRTSTI 156
Cdd:COG0463   81 ARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLiregESDLRRLGSRLFNLVR-------LLTNLPDSTSGFR 153

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 727180963 157 SVRKKQDRRFLFPEflARYQDWGFLvNATNLGARVVH 193
Cdd:COG0463  154 LFRREVLEELGFDE--GFLEDTELL-RALRHGFRIAE 187
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-89 2.69e-11

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 61.55  E-value: 2.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   1 MDLSIVIPAFNNSNHLAATLARMTHYCAGfDYEIIVVDYSSEAGESEKIHGLlaANHRARLHESRVRGNIAVACNIGFRL 80
Cdd:COG1216    3 PKVSVVIPTYNRPELLRRCLESLLAQTYP-PFEVIVVDNGSTDGTAELLAAL--AFPRVRVIRNPENLGFAAARNLGLRA 79


                 ....*....
gi 727180963  81 ARSEVVFFL 89
Cdd:COG1216   80 AGGDYLLFL 88
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 1-115 5.91e-11

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 62.07  E-value: 5.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   1 MDLSIVIPAFNNSNHLAATLARMTH--YcAGFDYEIIVVDYSSEAGESEKIHGLLAANHRARLHESRVRGNIAVACNIGF 78
Cdd:COG1215   29 PRVSVIIPAYNEEAVIEETLRSLLAqdY-PKEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIERPENGGKAAALNAGL 107

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727180963  79 RLARSEVVFFLEPEDMFGTNYIIRRLRRHEDTRIDIV 115
Cdd:COG1215  108 KAARGDIVVFLDADTVLDPDWLRRLVAAFADPGVGAS 144
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-146 1.39e-10

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 58.67  E-value: 1.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   5 IVIPAFNNSNHLAATLARMTH--YCagfDYEIIVVDYSSEAGESEKIHGLLAANHRARLHESRVRGNIAVACNIGFRLAR 82
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAqtYP---NFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAAR 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180963  83 SEVVFFLEPEDMFGTNYIIRRLRR-HEDTRIDIVFGNYTTVNDKNVRSYVFNYQE--GVAGEDFLFI 146
Cdd:cd00761   78 GEYILFLDADDLLLPDWLERLVAElLADPEADAVGGPGNLLFRRELLEEIGGFDEalLSGEEDDDFL 144
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-128 2.07e-10

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 58.56  E-value: 2.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963    4 SIVIPAFNNSNHLAATLARMTHYCaGFDYEIIVVDYSSEAGESEKIHGLLAANHRARLHESRVRGNIAVACNIGFRLARS 83
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQT-YPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 727180963   84 EVVFFLEPEDMFGTNYIIRRLRRHEDTRIDIVFGNYTTVNDKNVR 128
Cdd:pfam00535  80 DYIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGETGE 124
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 5-118 3.52e-10

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 57.97  E-value: 3.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   5 IVIPAFNNSNHLAATLARMTHYCA-GFDYEIIVVDYSSEAGESEKIHGLLAANHRAR-LHESRVRGNIAvACNIGFRLAR 82
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAVLEeGYDYEIIVVDDGSTDGTAEIARELAARVPRVRvIRLSRNFGKGA-AVRAGFKAAR 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 727180963  83 SEVVFFL------EPEDmfgtnyIIRRLRRHEDTRIDIVFGN 118
Cdd:cd04179   80 GDIVVTMdadlqhPPED------IPKLLEKLLEGGADVVIGS 115
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 5-123 2.02e-09

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 55.70  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   5 IVIPAFNNSNHLAATLarmtHYCAGFDY---EIIVVDYSSEAGESEKIHGLLAANHRARLHEsRVRGNI--AVACNIGFR 79
Cdd:cd06423    1 IIVPAYNEEAVIERTI----ESLLALDYpklEVIVVDDGSTDDTLEILEELAALYIRRVLVV-RDKENGgkAGALNAGLR 75

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 727180963  80 LARSEVVFFLEPEDMFGTNYIIRRLRRH-EDTRIDIVFGNYTTVN 123
Cdd:cd06423   76 HAKGDIVVVLDADTILEPDALKRLVVPFfADPKVGAVQGRVRVRN 120
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 5-134 1.71e-06

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 47.47  E-value: 1.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   5 IVIPAFNNSNHLAATLARMTHYCA--GFDYEIIVVDYSSEAGESEKIHGLLAANHRARL-HESRVRGN-IAVACniGFRL 80
Cdd:cd04187    1 IVVPVYNEEENLPELYERLKAVLEslGYDYEIIFVDDGSTDRTLEILRELAARDPRVKViRLSRNFGQqAALLA--GLDH 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727180963  81 ARSEVVFFL------EPEDmfgtnyiIRRLRRHEDTRIDIVFGNYTTVND---KNVRSYVFNY 134
Cdd:cd04187   79 ARGDAVITMdadlqdPPEL-------IPEMLAKWEEGYDVVYGVRKNRKEswlKRLTSKLFYR 134
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 3-89 1.78e-06

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 47.95  E-value: 1.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   3 LSIVIPAFNNSNHLAATLARMTHyCAGFDYEIIVVDYSSEAGESEkihglLAANHRARLHESRvRGNiAVACNIGFRLAR 82
Cdd:cd02522    1 LSIIIPTLNEAENLPRLLASLRR-LNPLPLEIIVVDGGSTDGTVA-----IARSAGVVVISSP-KGR-ARQMNAGAAAAR 72


                 ....*..
gi 727180963  83 SEVVFFL 89
Cdd:cd02522   73 GDWLLFL 79
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 4-122 1.94e-06

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 48.00  E-value: 1.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   4 SIVIPAFNNSNHLAATLARM--THYcAGFDYEIIVVDYSSEAGESEKIHGLLAANHRARLhESRVRGNIAVACNIGFRLA 81
Cdd:cd02525    3 SIIIPVRNEEKYIEELLESLlnQSY-PKDLIEIIVVDGGSTDGTREIVQEYAAKDPRIRL-IDNPKRIQSAGLNIGIRNS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 727180963  82 RSEVVFFLEPEDMFGTNYIIRRLRRHEDTRIDIVFGNYTTV 122
Cdd:cd02525   81 RGDIIIRVDAHAVYPKDYILELVEALKRTGADNVGGPMETI 121
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 5-87 2.99e-06

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 47.14  E-value: 2.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   5 IVIPAFNNSNHLAATLARMTHYCAGFDYEIIVVDYSSEAGESEKIHGLLAANHRARL-HESRVRGnIAVACNIGFRLARS 83
Cdd:cd06442    1 IIIPTYNERENIPELIERLDAALKGIDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLiVRPGKRG-LGSAYIEGFKAARG 79


                 ....
gi 727180963  84 EVVF 87
Cdd:cd06442   80 DVIV 83
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-91 4.23e-06

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 46.01  E-value: 4.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   5 IVIPAFNNSNHLAATLA--RMTHYCagfDYEIIVVDYSSEAGESEKIHGLLAanhRARLHESRVRGNIAVACNIGFRLAR 82
Cdd:cd04186    1 IIIVNYNSLEYLKACLDslLAQTYP---DFEVIVVDNASTDGSVELLRELFP---EVRLIRNGENLGFGAGNNQGIREAK 74


                 ....*....
gi 727180963  83 SEVVFFLEP 91
Cdd:cd04186   75 GDYVLLLNP 83
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 5-89 1.06e-05

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 45.64  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   5 IVIPAFNNSNHLAATLARMTHY---CAGFDYEIIVVDYSSEAGESEKIHGLLAAN--HRARLHESRVRGNiAVACNIGFR 79
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEAVEYleeRPSFSYEIIVVDDGSKDGTAEVARKLARKNpaLIRVLTLPKNRGK-GGAVRAGML 79

                         90
                 ....*....|
gi 727180963  80 LARSEVVFFL 89
Cdd:cd04188   80 AARGDYILFA 89
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 4-123 1.29e-04

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 42.57  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   4 SIVIPAFNNSNHLAATLARmthyCAGFDY-----EIIVVDYSSEAGESEKIHGLLAanHRARLHESRVRGNIAVACNIGF 78
Cdd:cd06439   32 TIIIPAYNEEAVIEAKLEN----LLALDYprdrlEIIVVSDGSTDGTAEIAREYAD--KGVKLLRFPERRGKAAALNRAL 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 727180963  79 RLARSEVVFF------LEPEdmfgtnyIIRRLRRH-EDTRIDIVFGNYTTVN 123
Cdd:cd06439  106 ALATGEIVVFtdanalLDPD-------ALRLLVRHfADPSVGAVSGELVIVD 150
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 3-129 1.80e-04

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 41.80  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   3 LSIVIPAFN-NSNHLAATLA--RMTHYCagfDYEIIVVDYSSEAGESEKIHGLLAANH-RARLHESRVRGNIAVACNIGF 78
Cdd:cd04184    3 ISIVMPVYNtPEKYLREAIEsvRAQTYP---NWELCIADDASTDPEVKRVLKKYAAQDpRIKVVFREENGGISAATNSAL 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 727180963  79 RLARSEVVFFLEPEDMFGTN---YIIRRLRRHEDtrIDIVFGNYTTVNDKNVRS 129
Cdd:cd04184   80 ELATGEFVALLDHDDELAPHalyEVVKALNEHPD--ADLIYSDEDKIDEGGKRS 131
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 4-131 5.24e-04

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 40.22  E-value: 5.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180963   4 SIVIPAFNNSNHLAATLA--RMTHYCagfDYEIIVVDYSSEAGESEKIHGllAANHRARLHESRVRGnIAVACNIGFRLA 81
Cdd:cd06433    1 SIITPTYNQAETLEETIDsvLSQTYP---NIEYIVIDGGSTDGTVDIIKK--YEDKITYWISEPDKG-IYDAMNKGIALA 74

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 727180963  82 RSEVVFFLEPEDMFGTNYIIRRLR-RHEDTRIDIVFGNYTTVNDKNVRSYV 131
Cdd:cd06433   75 TGDIIGFLNSDDTLLPGALLAVVAaFAEHPEVDVVYGDVLLVDENGRVIGR 125
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 1-38 1.39e-03

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 39.75  E-value: 1.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 727180963   1 MDLSIVIPAFNNSNHLAATLARMTHYCAG-------FDYEIIVVD 38
Cdd:PTZ00260  70 VDLSIVIPAYNEEDRLPKMLKETIKYLESrsrkdpkFKYEIIIVN 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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