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Conserved domains on  [gi|727180696|ref|WP_033643168|]
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MULTISPECIES: cysteine hydrolase family protein [Serratia]

Protein Classification

cysteine hydrolase family protein( domain architecture ID 10099067)

cysteine hydrolase family protein related to isochorismatase and nicotinamidase; catalyzes the hydrolysis of a chemical bond using an active site cysteinyl residue

EC:  3.-.-.-
Gene Ontology:  GO:0016787

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 10-162 1.19e-47

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


:

Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 152.36  E-value: 1.19e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  10 ALLVIDMQVGLFaSPDHPPFAAETLLAKTHALIRAARVANALVVFIRHTGPAGSPIAANSPLWQVHPDLDTdAQADWFID 89
Cdd:cd01014    1 ALLVIDVQNGYF-DGGLPPLNNEAALENIAALIAAARAAGIPVIHVRHIDDEGGSFAPGSEGWEIHPELAP-LEGETVIE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180696  90 KTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAHSCSDTA----ALGADAIIRHH 162
Cdd:cd01014   79 KTVPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFDLPdhggVLSAEEIHAHY 155
 
Name Accession Description Interval E-value
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 10-162 1.19e-47

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 152.36  E-value: 1.19e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  10 ALLVIDMQVGLFaSPDHPPFAAETLLAKTHALIRAARVANALVVFIRHTGPAGSPIAANSPLWQVHPDLDTdAQADWFID 89
Cdd:cd01014    1 ALLVIDVQNGYF-DGGLPPLNNEAALENIAALIAAARAAGIPVIHVRHIDDEGGSFAPGSEGWEIHPELAP-LEGETVIE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180696  90 KTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAHSCSDTA----ALGADAIIRHH 162
Cdd:cd01014   79 KTVPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFDLPdhggVLSAEEIHAHY 155
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 10-174 2.20e-38

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 129.25  E-value: 2.20e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  10 ALLVIDMQVGLFASPDHPPFAAETLLAKTHALIRAARVANALVVFIRHTGPAGSPIAA-----------NSPLWQVHPDL 78
Cdd:COG1335    1 ALLVIDVQNDFVPPGALAVPGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAefdlwpphcvpGTPGAELVPEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  79 DTDAqADWFIDKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAHSCSDtaalgaDAI 158
Cdd:COG1335   81 APLP-GDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRD------PEA 153

                        170
                 ....*....|....*.
gi 727180696 159 IRHHNQTLSGPFVTLA 174
Cdd:COG1335  154 HEAALARLRAAGATVV 169
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 9-161 2.27e-32

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 114.04  E-value: 2.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696    9 SALLVIDMQVGLFASPDHPPFAAETLLAKTHALIRAARVANALVVFIRHTGPAGSP-----------IAANSPLWQVHPD 77
Cdd:pfam00857   1 TALLVIDMQNDFVDSGGPKVEGIAAILENINRLLKAARKAGIPVIFTRQVPEPDDAdfalkdrpspaFPPGTTGAELVPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696   78 LDTDAQaDWFIDKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAhsCSDTAALGADA 157
Cdd:pfam00857  81 LAPLPG-DLVVDKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDA--CASLSPEAHDA 157


                  ....
gi 727180696  158 IIRH 161
Cdd:pfam00857 158 ALER 161
PLN02621 PLN02621
nicotinamidase
 5-149 1.69e-15

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 70.96  E-value: 1.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696   5 PAPR-SALLVIDMQvGLFASPDHPPFAAetlLAKTHALIRAARVAnalVVFIRHT--GPA----------GSPIAANSPL 71
Cdd:PLN02621  16 PDPKqAALLVIDMQ-NYFSSMAEPILPA---LLTTIDLCRRASIP---VFFTRHShkSPSdygmlgewwdGDLILDGTTE 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180696  72 WQVHPDLDTDAQADWFIDKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAHSCSD 149
Cdd:PLN02621  89 AELMPEIGRVTGPDEVVEKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATAN 166
 
Name Accession Description Interval E-value
nicotinamidase_related cd01014
Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share ...
 10-162 1.19e-47

Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia.


Pssm-ID: 238496 [Multi-domain]  Cd Length: 155  Bit Score: 152.36  E-value: 1.19e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  10 ALLVIDMQVGLFaSPDHPPFAAETLLAKTHALIRAARVANALVVFIRHTGPAGSPIAANSPLWQVHPDLDTdAQADWFID 89
Cdd:cd01014    1 ALLVIDVQNGYF-DGGLPPLNNEAALENIAALIAAARAAGIPVIHVRHIDDEGGSFAPGSEGWEIHPELAP-LEGETVIE 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727180696  90 KTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAHSCSDTA----ALGADAIIRHH 162
Cdd:cd01014   79 KTVPNAFYGTDLEEWLREAGIDHLVICGAMTEMCVDTTVRSAFDLGYDVTVVADACATFDLPdhggVLSAEEIHAHY 155
PncA COG1335
Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction ...
 10-174 2.20e-38

Nicotinamidase-related amidase [Coenzyme transport and metabolism, General function prediction only]; Nicotinamidase-related amidase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440946 [Multi-domain]  Cd Length: 169  Bit Score: 129.25  E-value: 2.20e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  10 ALLVIDMQVGLFASPDHPPFAAETLLAKTHALIRAARVANALVVFIRHTGPAGSPIAA-----------NSPLWQVHPDL 78
Cdd:COG1335    1 ALLVIDVQNDFVPPGALAVPGADAVVANIARLLAAARAAGVPVIHTRDWHPPDGSEFAefdlwpphcvpGTPGAELVPEL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  79 DTDAqADWFIDKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAHSCSDtaalgaDAI 158
Cdd:COG1335   81 APLP-GDPVVDKTRYSAFYGTDLDELLRERGIDTLVVAGLATDVCVLSTARDALDLGYEVTVVEDACASRD------PEA 153

                        170
                 ....*....|....*.
gi 727180696 159 IRHHNQTLSGPFVTLA 174
Cdd:COG1335  154 HEAALARLRAAGATVV 169
cysteine_hydrolases cd00431
Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine ...
 10-161 5.17e-36

Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It also contains isochorismatase, an enzyme that catalyzes the conversion of isochorismate to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of the vinyl ether bond, and other related enzymes with unknown function.


Pssm-ID: 238245 [Multi-domain]  Cd Length: 161  Bit Score: 122.76  E-value: 5.17e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  10 ALLVIDMQVGLFASPDHPPFAAETLLAKTHALIRAARVANALVVFIRHTGPAGSP----------IAANSPLWQVHPDLD 79
Cdd:cd00431    1 ALLVVDMQNDFVPGGGLLLPGADELVPNINRLLAAARAAGIPVIFTRDWHPPDDPefaellwpphCVKGTEGAELVPELA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  80 TDAqADWFIDKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAhsCSDTAALGADAII 159
Cdd:cd00431   81 PLP-DDLVIEKTRYSAFYGTDLDELLRERGIDTLVVCGIATDICVLATARDALDLGYRVIVVEDA--CATRDEEDHEAAL 157


                 ..
gi 727180696 160 RH 161
Cdd:cd00431  158 ER 159
Isochorismatase pfam00857
Isochorismatase family; This family are hydrolase enzymes.
 9-161 2.27e-32

Isochorismatase family; This family are hydrolase enzymes.


Pssm-ID: 376404 [Multi-domain]  Cd Length: 173  Bit Score: 114.04  E-value: 2.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696    9 SALLVIDMQVGLFASPDHPPFAAETLLAKTHALIRAARVANALVVFIRHTGPAGSP-----------IAANSPLWQVHPD 77
Cdd:pfam00857   1 TALLVIDMQNDFVDSGGPKVEGIAAILENINRLLKAARKAGIPVIFTRQVPEPDDAdfalkdrpspaFPPGTTGAELVPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696   78 LDTDAQaDWFIDKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAhsCSDTAALGADA 157
Cdd:pfam00857  81 LAPLPG-DLVVDKTRFSAFAGTDLDEILRELGIDTLVLAGVATDVCVLSTARDALDRGYEVVVVSDA--CASLSPEAHDA 157


                  ....
gi 727180696  158 IIRH 161
Cdd:pfam00857 158 ALER 161
PLN02621 PLN02621
nicotinamidase
 5-149 1.69e-15

nicotinamidase


Pssm-ID: 178229  Cd Length: 197  Bit Score: 70.96  E-value: 1.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696   5 PAPR-SALLVIDMQvGLFASPDHPPFAAetlLAKTHALIRAARVAnalVVFIRHT--GPA----------GSPIAANSPL 71
Cdd:PLN02621  16 PDPKqAALLVIDMQ-NYFSSMAEPILPA---LLTTIDLCRRASIP---VFFTRHShkSPSdygmlgewwdGDLILDGTTE 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727180696  72 WQVHPDLDTDAQADWFIDKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAHSCSD 149
Cdd:PLN02621  89 AELMPEIGRVTGPDEVVEKSTYSAFYNTRLEERLRKIGVKEVIVTGVMTNLCCETTAREAFVRGFRVFFSTDATATAN 166
EntB1 COG1535
Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
8-166 2.18e-14

Isochorismate hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441144 [Multi-domain]  Cd Length: 204  Bit Score: 67.95  E-value: 2.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696   8 RSALLVIDMQ---VGLFAsPDHPPfaAETLLAKTHALIRAARVANALVVFIRHTG---PA---------GSPIAANSPLW 72
Cdd:COG1535   19 RAALLIHDMQnyfLRPYD-PDEPP--IRELVANIARLRDACRAAGIPVVYTAQPGdqtPEdrgllndfwGPGLTAGPEGQ 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  73 QVHPDLDTDAQaDWFIDKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAhscsdTAA 152
Cdd:COG1535   96 EIVDELAPAPG-DTVLTKWRYSAFQRTDLEERLRELGRDQLIITGVYAHIGCLATAVDAFMRDIQPFVVADA-----VAD 169

                        170
                 ....*....|....
gi 727180696 153 LGADaiirHHNQTL 166
Cdd:COG1535  170 FSRE----EHRMAL 179
PRK11440 PRK11440
putative hydrolase; Provisional
 1-151 2.37e-12

putative hydrolase; Provisional


Pssm-ID: 183137  Cd Length: 188  Bit Score: 62.05  E-value: 2.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696   1 MPTIPAPRSALLVIDMQVGL--FASPdhpPFAAETLLAKTHALIRAARVANALVVFIRhTG-----------PAGSPIAA 67
Cdd:PRK11440   1 MLELNAKTTALVVIDLQEGIlpFAGG---PHTADEVVARAARLAAKFRASGSPVVLVR-VGwsadyaealkqPVDAPSPA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  68 NS--PLWQVHPDLDTDAQADWFIDKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAH 145
Cdd:PRK11440  77 KVlpENWWQHPAALGKTDSDIEVTKRQWGAFYGTDLELQLRRRGIDTIVLCGISTNIGVESTARNAWELGFNLVIAEDAC 156


                 ....*.
gi 727180696 146 SCSDTA 151
Cdd:PRK11440 157 SAASAE 162
YcaC_related cd01012
YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown ...
 10-150 2.09e-09

YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them. Multimerisation interface seems not to be conserved in all members.


Pssm-ID: 238494 [Multi-domain]  Cd Length: 157  Bit Score: 53.75  E-value: 2.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  10 ALLVIDMQVGLFASPDHPPfaaeTLLAKTHALIRAARVANALVVFIRH-TGPAGSPIaansplwqvhPDLDTDAQADWFI 88
Cdd:cd01012    1 ALLLVDVQEKLAPAIKSFD----ELINNTVKLAKAAKLLDVPVILTEQyPKGLGPTV----------PELREVFPDAPVI 66

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727180696  89 DKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAhsCSDT 150
Cdd:cd01012   67 EKTSFSCWEDEAFRKALKATGRKQVVLAGLETHVCVLQTALDLLEEGYEVFVVADA--CGSR 126
CSHase cd01015
N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, ...
 10-153 7.45e-08

N-carbamoylsarcosine amidohydrolase (CSHase) hydrolyzes N-carbamoylsarcosine to sarcosine, carbon dioxide and ammonia. CSHase is involved in one of the two alternative pathways for creatinine degradation to glycine in microorganisms.This CSHase-containing pathway degrades creatinine via N-methylhydantoin N-carbamoylsarcosine and sarcosine to glycine. Enzymes of this pathway are used in the diagnosis for renal disfunction, for determining creatinine levels in urine and serum.


Pssm-ID: 238497 [Multi-domain]  Cd Length: 179  Bit Score: 49.71  E-value: 7.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  10 ALLVIDMQVGlFASPDHPPFAA-ETLLAKTHALIRAARVANALVVfirHTGPAGSPIAANSPLW---------QVHPDLD 79
Cdd:cd01015    1 ALLVIDLVEG-YTQPGSYLAPGiAAALENVQRLLAAARAAGVPVI---HTTVVYDPDGADGGLWarkvpamsdLVEGSPL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  80 TD-------AQADWFIDKTHPSCFYRTGLAERLKQAGIGRLVISGMKTQYCVDTACRRGAELGFDLVLAADAhsCSDTAA 152
Cdd:cd01015   77 AAicdelapQEDEMVLVKKYASAFFGTSLAATLTARGVDTLIVAGCSTSGCIRATAVDAMQHGFRPIVVREC--VGDRAP 154


                 .
gi 727180696 153 L 153
Cdd:cd01015  155 A 155
nicotinamidase cd01011
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, ...
 8-144 1.52e-07

Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).


Pssm-ID: 238493  Cd Length: 196  Bit Score: 49.18  E-value: 1.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696   8 RSALLVIDMQVGlFASPDHPPFA-AETLLAKTHALIRAARVAnaLVVFIRHTGPA-GSPIAANSP--------------L 71
Cdd:cd01011    1 TDALLVVDVQND-FCPGGALAVPgGDAIVPLINALLSLFQYD--LVVATQDWHPAnHASFASNHPgqmpfitlppgpqvL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  72 W-----------QVHPDLDTDAqADWFIDK-THP-----SCFY------RTGLAERLKQAGIGRLVISGMKTQYCVDTAC 128
Cdd:cd01011   78 WpdhcvqgtpgaELHPGLPVPD-IDLIVRKgTNPdidsySAFFdndrrsSTGLAEYLRERGIDRVDVVGLATDYCVKATA 156

                        170
                 ....*....|....*.
gi 727180696 129 RRGAELGFDLVLAADA 144
Cdd:cd01011  157 LDALKAGFEVRVLEDA 172
PTZ00331 PTZ00331
alpha/beta hydrolase; Provisional
 1-158 3.37e-07

alpha/beta hydrolase; Provisional


Pssm-ID: 240363  Cd Length: 212  Bit Score: 48.52  E-value: 3.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696   1 MPTIPAPRS----ALLVIDMQV-----GLFASPDhppfaAETLLAKTHALirAARVANALVVF-------------IRHT 58
Cdd:PTZ00331   1 MSTSCITVSstndALIIVDVQNdfckgGSLAVPD-----AEEVIPVINQV--RQSHHFDLVVAtqdwhppnhisfaSNHG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727180696  59 GPAGSPIAANSPLW-----------QVHPDL-----------DTDAQADWFidkthpSCFY-----RTGLAERLKQAGIG 111
Cdd:PTZ00331  74 KPKILPDGTTQGLWpphcvqgtkgaQLHKDLvveridiiirkGTNRDVDSY------SAFDndkgsKTGLAQILKAHGVR 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 727180696 112 RLVISGMKTQYCVDTACRRGAELGFDLVLAADAhscsdTAALGADAI 158
Cdd:PTZ00331 148 RVFICGLAFDFCVLFTALDAVKLGFKVVVLEDA-----TRAVDPDAI 189
PRK11609 PRK11609
bifunctional nicotinamidase/pyrazinamidase;
68-124 3.01e-03

bifunctional nicotinamidase/pyrazinamidase;


Pssm-ID: 183228  Cd Length: 212  Bit Score: 36.89  E-value: 3.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727180696  68 NSPLWQVHPDLDTDAqADWFIDK-THP-----SCFY------RTGLAERLKQAGIGRLVISGMKTQYCV 124
Cdd:PRK11609  89 NSEGAALHPLLNQKA-IDAVFHKgENPlidsySAFFdnghrqKTALDDWLREHGITELIVMGLATDYCV 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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