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Conserved domains on  [gi|727171005|ref|WP_033638694|]
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MULTISPECIES: response regulator transcription factor [Serratia]

Protein Classification

response regulator transcription factor( domain architecture ID 1013612)

two-component system response regulator transcription factor binds DNA upon phosphorylation and functions as transcriptional regulator

CATH:  3.40.50.2300
Gene Ontology:  GO:0000156|GO:0000160|GO:0003677|GO:0006355
PubMed:  31100988|10966457
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15369 super family cl33127
two component system response regulator;
3-193 9.91e-35

two component system response regulator;


The actual alignment was detected with superfamily member PRK15369:

Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 122.11  E-value: 9.91e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:PRK15369   5 KILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVLT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGETHF------PAAALAEEAPTADGGLLTPKELEVLGLLSQG 156
Cdd:PRK15369  85 ARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIdpalnrEAILALLNADDTNPPLLTPRERQILKLITEG 164

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 727171005 157 LSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELV 193
Cdd:PRK15369 165 YTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELL 201
 
Name Accession Description Interval E-value
PRK15369 PRK15369
two component system response regulator;
3-193 9.91e-35

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 122.11  E-value: 9.91e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:PRK15369   5 KILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVLT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGETHF------PAAALAEEAPTADGGLLTPKELEVLGLLSQG 156
Cdd:PRK15369  85 ARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIdpalnrEAILALLNADDTNPPLLTPRERQILKLITEG 164

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 727171005 157 LSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELV 193
Cdd:PRK15369 165 YTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELL 201
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 6-199 1.00e-24

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 95.55  E-value: 1.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   6 LVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQe 85
Cdd:COG4566    4 IVDDDEAVRDSLAFLL--ESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGH- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  86 AEVyaRMA-HA--AGANGFVNKGSSLAELLQAIEQVLDGETHFPAAALAEEAPTADGGLLTPKELEVLGLLSQGLSNLQI 162
Cdd:COG4566   81 GDV--PMAvRAmkAGAVDFLEKPFDDQALLDAVRRALARDRARRAERARRAELRARLASLTPREREVLDLVVAGLSNKQI 158

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 727171005 163 ADRLHISNKTVSTHKKNIQRKTGAGNLLELVAVFKEL 199
Cdd:COG4566  159 ARELGISPRTVEVHRANVMEKLGARSLAELVRLALAL 195
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 5-119 1.63e-24

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 92.58  E-value: 1.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQ 84
Cdd:cd17535    2 LIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTAH 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727171005  85 EAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17535   82 DDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVA 116
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 5-116 4.12e-22

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 86.44  E-value: 4.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005    5 LLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQ 84
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEG--YVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAH 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 727171005   85 EAEVYARMAHAAGANGFVNKGSSLAELLQAIE 116
Cdd:pfam00072  80 GDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 142-194 3.35e-21

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 82.57  E-value: 3.35e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 727171005   142 LTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELVA 194
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVR 56
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 155-179 1.04e-03

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 38.31  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*
gi 727171005  155 QGLSNLQIADRLHISNKTVSTHKKN 179
Cdd:TIGR02985 128 EGLSNKEIAEELGISVKTVEYHITK 152
 
Name Accession Description Interval E-value
PRK15369 PRK15369
two component system response regulator;
3-193 9.91e-35

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 122.11  E-value: 9.91e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:PRK15369   5 KILLVDDHELIINGIKNMLAPYPRYKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNILVLT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGETHF------PAAALAEEAPTADGGLLTPKELEVLGLLSQG 156
Cdd:PRK15369  85 ARQEEHMASRTLAAGALGYVLKKSPQQILLAAIQTVAVGKRYIdpalnrEAILALLNADDTNPPLLTPRERQILKLITEG 164

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 727171005 157 LSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELV 193
Cdd:PRK15369 165 YTNRDIAEQLSISIKTVETHRLNMMRKLDVHKVAELL 201
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
3-197 8.00e-31

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 111.89  E-value: 8.00e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:PRK09935   5 SVIIMDTHPIIRMSIEVLLQKNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGETHFPAAALAEEAPTADGG------LLTPKELEVLGLLSQG 156
Cdd:PRK09935  85 SKSECFYAGRAIQAGANGFVSKCNDQNDIFHAVQMILSGYTFFPSETLNYIKSNKCSTnsstdtVLSNREVTILRYLVSG 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 727171005 157 LSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELVAVFK 197
Cdd:PRK09935 165 LSNKEIADQLLLSNKTVSAHKSNIYGKLGLHSIVELIDYAK 205
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
5-192 4.67e-27

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 101.90  E-value: 4.67e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAaLMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQ 84
Cdd:PRK09958   4 IIIDDHPLAIAAIRN-LLIKNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSAK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  85 EAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGETHFPAAALAEEAPTADGG----LLTPKELEVLGLLSQGLSNL 160
Cdd:PRK09958  83 NDHFYGKHCADAGANGFVSKKEGMNNIIAAIEAAKNGYCYFPFSLNRFVGSLTSDQqkldSLSKQEISVMRYILDGKDNN 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 727171005 161 QIADRLHISNKTVSTHKKNIQRKTGAGNLLEL 192
Cdd:PRK09958 163 DIAEKMFISNKTVSTYKSRLMEKLECKSLMDL 194
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
 6-199 1.00e-24

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 95.55  E-value: 1.00e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   6 LVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQe 85
Cdd:COG4566    4 IVDDDEAVRDSLAFLL--ESAGLRVETFASAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVIFLTGH- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  86 AEVyaRMA-HA--AGANGFVNKGSSLAELLQAIEQVLDGETHFPAAALAEEAPTADGGLLTPKELEVLGLLSQGLSNLQI 162
Cdd:COG4566   81 GDV--PMAvRAmkAGAVDFLEKPFDDQALLDAVRRALARDRARRAERARRAELRARLASLTPREREVLDLVVAGLSNKQI 158

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 727171005 163 ADRLHISNKTVSTHKKNIQRKTGAGNLLELVAVFKEL 199
Cdd:COG4566  159 ARELGISPRTVEVHRANVMEKLGARSLAELVRLALAL 195
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 5-119 1.63e-24

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 92.58  E-value: 1.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQ 84
Cdd:cd17535    2 LIVDDHPLVREGLRRLLESEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLTAH 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727171005  85 EAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17535   82 DDPEYVLRALKAGAAGYLLKDSSPEELIEAIRAVA 116
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 5-116 4.12e-22

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 86.44  E-value: 4.12e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005    5 LLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQ 84
Cdd:pfam00072   2 LIVDDDPLIRELLRQLLEKEG--YVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILTAH 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 727171005   85 EAEVYARMAHAAGANGFVNKGSSLAELLQAIE 116
Cdd:pfam00072  80 GDEDDAVEALEAGADDFLSKPFDPDELLAAIR 111
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-186 1.09e-21

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 87.70  E-value: 1.09e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILI 80
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREG--YEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPIIM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  81 YTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL-----DGETHFPAAALAEEAPTADGGL--LTPKELEVLGLL 153
Cdd:COG0745   79 LTARDDEEDRVRGLEAGADDYLTKPFDPEELLARIRALLrrraaEVLRVGDLLDLAAREVTRDGEPveLTPKEFRLLELL 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 727171005 154 S----QGLSNLQIADRL----HISNKTVSTHKKNIQRKTGA 186
Cdd:COG0745  159 MrnpgRVVSREQLLEEVwgydYGDDRTVDVHISRLRKKLED 199
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-199 3.17e-21

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 84.56  E-value: 3.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIrrrypqqpili 80
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLEAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL----------- 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  81 ytaqeaevyarmahaagangfvnkgsslaellqaieqvldgethfpaaalaeeaptadgglLTPKELEVLGLLSQGLSNL 160
Cdd:COG2197   70 -------------------------------------------------------------LTPREREVLRLLAEGLSNK 88

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 727171005 161 QIADRLHISNKTVSTHKKNIQRKTGAGNLLELVAVFKEL 199
Cdd:COG2197   89 EIAERLGISERTVKTHVSNILRKLGVRNRTELVLLALRL 127
HTH_LUXR smart00421
helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon
 142-194 3.35e-21

helix_turn_helix, Lux Regulon; lux regulon (activates the bioluminescence operon


Pssm-ID: 197715 [Multi-domain]  Cd Length: 58  Bit Score: 82.57  E-value: 3.35e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 727171005   142 LTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELVA 194
Cdd:smart00421   4 LTPREREVLRLLAEGLTNKEIAERLGISEKTVKTHLSNIMRKLGVRSRTQAVR 56
LuxR_C_like cd06170
C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix ...
 142-194 5.34e-20

C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many are active as homodimers. Many are two domain proteins in which the DNA binding property of the C-terminal DNA binding domain is modulated by modifications of the N-terminal domain. For example in the case of Lux R which participates in the regulation of gene expression in response to fluctuations in cell-population density (quorum-sensing), a signaling molecule, the pheromone Acyl HSL (N-acyl derivatives of homoserine lactone), binds to the N-terminal domain and leads to LuxR dimerization. For others phophorylation of the N-terminal domain leads to multimerization, for example Escherichia coli NarL and Sinorhizobium melilot FixJ. NarL controls gene expression of many respiratory-related operons when environmental nitrate or nitrite is present under anerobic conditions. FixJ is involved in the transcriptional activation of nitrogen fixation genes. The group also includes small proteins which lack an N-terminal signaling domain, such as Bacillus subtilis GerE. GerE is dimeric and acts in conjunction with sigmaK as an activator or a repressor modulating the expression of various genes in particular those encoding the spore-coat. These LuxR family regulators may share a similar organization of their target binding sites. For example the LuxR dimer binds the lux box, a 20bp inverted repeat, GerE dimers bind two 12bp consensus sequences in inverted orientation having the central four bases overlap, and the NarL dimer binds two 7bp inverted repeats separated by 2 bp.


Pssm-ID: 99777 [Multi-domain]  Cd Length: 57  Bit Score: 79.12  E-value: 5.34e-20
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 727171005 142 LTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELVA 194
Cdd:cd06170    1 LTPREREVLRLLAEGKTNKEIADILGISEKTVKTHLRNIMRKLGVKSRTQLVA 53
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-120 2.32e-19

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 84.63  E-value: 2.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILI 80
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELL--ERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVIL 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 727171005  81 YTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLD 120
Cdd:COG2204   80 LTGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALE 119
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-123 3.47e-19

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 79.12  E-value: 3.47e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRR--YPQQPI 78
Cdd:COG0784    5 GKRILVVDDNPDNRELLRRLL--ERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALprLPDIPI 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 727171005  79 LIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGET 123
Cdd:COG0784   83 IALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARAS 127
GerE pfam00196
Bacterial regulatory proteins, luxR family;
142-196 2.05e-18

Bacterial regulatory proteins, luxR family;


Pssm-ID: 425517 [Multi-domain]  Cd Length: 57  Bit Score: 75.31  E-value: 2.05e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 727171005  142 LTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELVAVF 196
Cdd:pfam00196   3 LSPREREVLRWLAAGKSNKEIADELGISEKTVKVHRSNIMRKLNVHSRVELVRMA 57
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-104 1.28e-17

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 74.19  E-value: 1.28e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQ 84
Cdd:cd00156    1 LIVDDDPAIRELLKSLL--EREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTAK 78

                         90       100
                 ....*....|....*....|
gi 727171005  85 EAEVYARMAHAAGANGFVNK 104
Cdd:cd00156   79 ADEEDAVRALELGADDYLVK 98
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
4-183 3.09e-17

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 76.43  E-value: 3.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:PRK10403   9 VLIVDDHPLMRRGVRQLLELDPGFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIIILTV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  84 QEA--EVYARMAhaAGANGFVNKGSSLAELLQAIEQVLDGETHFPAAALAEEAPTADGG-------LLTPKELEVLGLLS 154
Cdd:PRK10403  89 SDAssDVFALID--AGADGYLLKDSDPEVLLEAIRAGAKGSKVFSERVNQYLREREMFGaeedpfsVLTERELDVLHELA 166

                        170       180
                 ....*....|....*....|....*....
gi 727171005 155 QGLSNLQIADRLHISNKTVSTHKKNIQRK 183
Cdd:PRK10403 167 QGLSNKQIASVLNISEQTVKVHIRNLLRK 195
GerE COG5905
Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell ...
 141-194 5.80e-16

Spore transcriptional regulator GerE (stand-alone HTH domain) [Cell cycle control, cell division, chromosome partitioning, Transcription];


Pssm-ID: 444607 [Multi-domain]  Cd Length: 76  Bit Score: 69.22  E-value: 5.80e-16
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 727171005 141 LLTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELVA 194
Cdd:COG5905   12 LLTKREREVLELLAEGLTNKEIARQLFISEKTVKNHVSNILRKLGVRNRVQAVV 65
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-118 7.35e-16

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 71.86  E-value: 7.35e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--RYPQQPI 78
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLL--EAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRAdpRTADIPI 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 727171005  79 LIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQV 118
Cdd:COG3706   79 IFLTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLV 118
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 3-185 1.44e-15

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 71.98  E-value: 1.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:PRK10651   8 TILLIDDHPMLRTGVKQLISMAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGE-------THFPAAALAEEAPTADGGL--LTPKELEVLGLL 153
Cdd:PRK10651  88 VSNHEEDVVTALKRGADGYLLKDMEPEDLLKALQQAAAGEmvlsealTPVLAASLRANRATTERDVnqLTPRERDILKLI 167

                        170       180       190
                 ....*....|....*....|....*....|..
gi 727171005 154 SQGLSNLQIADRLHISNKTVSTHKKNIQRKTG 185
Cdd:PRK10651 168 AQGLPNKMIARRLDITESTVKVHVKHMLKKMK 199
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-120 8.68e-15

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 69.81  E-value: 8.68e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQ--PI 78
Cdd:COG3437    6 APTVLIVDDDPENLELLRQLL--RTLGYDVVTAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPSTRdiPV 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 727171005  79 LIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLD 120
Cdd:COG3437   84 IFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALE 125
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-120 2.84e-14

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 66.53  E-value: 2.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILI 80
Cdd:COG4565    3 MIRVLIVEDDPMVAELLRRYLERLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDVIV 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 727171005  81 YTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLD 120
Cdd:COG4565   83 ITAARDPETVREALRAGVVDYLIKPFTFERLREALERYLE 122
fixJ PRK09390
response regulator FixJ; Provisional
 7-193 4.83e-14

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 67.33  E-value: 4.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   7 VDDHPVVHVALEAALMKSSRPYRL-QAAQDdvqALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQE 85
Cdd:PRK09390   9 VDDDEAMRDSLAFLLDSAGFEVRLfESAQA---FLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIVMTGHG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  86 AEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGETHFPAAALAEEAPTADGGLLTPKELEVLGLLSQGLSNLQIADR 165
Cdd:PRK09390  86 DVPLAVEAMKLGAVDFIEKPFEDERLIGAIERALAQAPEAAKSEAVAADIRARIASLSERERQVMDGLVAGLSNKVIARD 165

                        170       180
                 ....*....|....*....|....*...
gi 727171005 166 LHISNKTVSTHKKNIQRKTGAGNLLELV 193
Cdd:PRK09390 166 LDISPRTVEVYRANVMTKMQAGSLSELV 193
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-104 1.00e-13

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 64.41  E-value: 1.00e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILEWEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIILS 80

                         90       100
                 ....*....|....*....|..
gi 727171005  83 AQEAEVYARMAHAAGANGFVNK 104
Cdd:COG4753   81 GYSDFEYAQEAIKLGADDYLLK 102
CsgD COG2771
DNA-binding transcriptional regulator, CsgD family [Transcription];
142-199 1.03e-13

DNA-binding transcriptional regulator, CsgD family [Transcription];


Pssm-ID: 442052 [Multi-domain]  Cd Length: 188  Bit Score: 66.70  E-value: 1.03e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727171005 142 LTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELVAVFKEL 199
Cdd:COG2771  128 LTPREREVLRLLAEGLTLKEIARILGISERTVRTHLKRIYRKLGVSSRAELVALALRL 185
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
 5-104 1.31e-13

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 63.97  E-value: 1.31e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQ 84
Cdd:cd17574    1 LVVEDDEEIAELLSDYLEKEG--YEVDTAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTAK 78

                         90       100
                 ....*....|....*....|
gi 727171005  85 EAEVYARMAHAAGANGFVNK 104
Cdd:cd17574   79 DEEEDKVLGLELGADDYITK 98
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 3-120 2.18e-13

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 63.97  E-value: 2.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVvHVAL-EAALMKSSRPYRLQAAQDDVQ-------ALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--R 72
Cdd:cd17557    1 TILLVEDNPG-DAELiQEAFKEAGVPNELHVVRDGEEaldflrgEGEYADAPRPDLILLDLNMPRMDGFEVLREIKAdpD 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 727171005  73 YPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLD 120
Cdd:cd17557   80 LRRIPVVVLTTSDAEEDIERAYELGANSYIVKPVDFEEFVEAIRSLGE 127
PRK10360 PRK10360
transcriptional regulator UhpA;
50-192 3.66e-12

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 62.30  E-value: 3.66e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRrypQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGETHFPAAA 129
Cdd:PRK10360  50 VCICDISMPDISGLELLSQLPK---GMATIMLSVHDSPALVEQALNAGARGFLSKRCSPDELIAAVHTVATGGCYLTPDI 126

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727171005 130 LAEEAPTADGGLlTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLEL 192
Cdd:PRK10360 127 AIKLASGRQDPL-TKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLMEKLGVSNDVEL 188
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
 2-115 8.90e-12

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 59.54  E-value: 8.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   2 PSLLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIY 81
Cdd:cd17554    1 KKILVVDDEENIRELYKEEL--EDEGYEVVTAGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVIIC 78

                         90       100       110
                 ....*....|....*....|....*....|....
gi 727171005  82 TAQeaEVYARMAHAAGANGFVNKGSSLAELLQAI 115
Cdd:cd17554   79 TAY--SEYKSDFSSWAADAYVVKSSDLTELKETI 110
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
 4-112 1.45e-11

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 58.83  E-value: 1.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:cd19934    1 LLLVEDDALLAAQLKEQLSDAG--YVVDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILTA 78

                         90       100
                 ....*....|....*....|....*....
gi 727171005  84 QEAEVYARMAHAAGANGFVNKGSSLAELL 112
Cdd:cd19934   79 RDSWQDKVEGLDAGADDYLTKPFHIEELL 107
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
 5-119 4.30e-11

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 57.62  E-value: 4.30e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQ 84
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEG--YTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTAL 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727171005  85 EAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17625   79 DAVEDRVKGLDLGADDYLPKPFSLAELLARIRALL 113
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
 3-193 1.14e-10

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 58.69  E-value: 1.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLP---QVDGLQLLKKIRRRYPQQPIL 79
Cdd:PRK10840   5 NVIIADDHPIVLFGIRKSLEQIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPgdkYGDGITLIKYIKRHFPSLSII 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  80 IYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGETHFPAAALAEEAPTADGGL----LTPKELEVLGLLSQ 155
Cdd:PRK10840  85 VLTMNNNPAILSAVLDLDIEGIVLKQGAPTDLPKALAALQKGKKFTPESVSRLLEKISAGGYgdkrLSPKESEVLRLFAE 164

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 727171005 156 GLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELV 193
Cdd:PRK10840 165 GFLVTEIAKKLNRSIKTISSQKKSAMMKLGVENDIALL 202
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 5-119 1.69e-10

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 56.16  E-value: 1.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--RYPQQPILIYT 82
Cdd:cd17562    4 LAVDDSASIRQMVSFTLRGAG--YEVVEAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKlpAYKFTPILMLT 81

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17562   82 TESSDEKKQEGKAAGATGWLVKPFDPEQLLEVVKKVL 118
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
 4-112 1.72e-10

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 55.95  E-value: 1.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:cd17624    1 ILLVEDDALLGDGLKTGLRKAG--YAVDWVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILTA 78

                         90       100       110
                 ....*....|....*....|....*....|
gi 727171005  84 QEAeVYARMAH-AAGANGFVNKGSSLAELL 112
Cdd:cd17624   79 RDG-VDDRVAGlDAGADDYLVKPFALEELL 107
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
 4-119 3.76e-10

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 55.12  E-value: 3.76e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYpQQPILIYTA 83
Cdd:cd17614    1 ILVVDDEKPISDILKFNLTKEG--YEVVTAYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTS-NVPIIMLTA 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 727171005  84 QEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17614   78 KDSEVDKVLGLELGADDYVTKPFSNRELLARVKANL 113
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 2-112 8.16e-10

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 54.32  E-value: 8.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   2 PSLLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRyPQQPILIY 81
Cdd:cd17619    1 PHILIVEDEPVTRATLKSYFEQEG--YDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQ-SEVGIILV 77

                         90       100       110
                 ....*....|....*....|....*....|.
gi 727171005  82 TAQEAEVYARMAHAAGANGFVNKGSSLAELL 112
Cdd:cd17619   78 TGRDDEVDRIVGLEIGADDYVTKPFNPRELL 108
PRK10643 PRK10643
two-component system response regulator PmrA;
4-112 9.22e-10

two-component system response regulator PmrA;


Pssm-ID: 182612 [Multi-domain]  Cd Length: 222  Bit Score: 56.20  E-value: 9.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:PRK10643   3 ILIVEDDTLLLQGLILAL--QTEGYACDCASTAREAEALLESGHYSLVVLDLGLPDEDGLHLLRRWRQKKYTLPVLILTA 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 727171005  84 QEAeVYARMAHA-AGANGFVNKGSSLAELL 112
Cdd:PRK10643  81 RDT-LEDRVAGLdVGADDYLVKPFALEELH 109
PRK09483 PRK09483
response regulator; Provisional
 1-192 1.07e-09

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 55.88  E-value: 1.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILI 80
Cdd:PRK09483   1 MINVLLVDDHELVRAGIRRILEDIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKIIM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  81 YTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGETHFP-----AAALAEEAPTADGGL--LTPKELEVLGLL 153
Cdd:PRK09483  81 LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVHSGQRYIAsdiaqQMALSQIEPATENPFasLSERELQIMLMI 160

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 727171005 154 SQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLEL 192
Cdd:PRK09483 161 TKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNISGDVEL 199
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 2-118 1.57e-09

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 54.92  E-value: 1.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   2 PSLLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPIL-- 79
Cdd:COG4567    5 RSLLLVDDDEAFARVLARAL--ERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVvl 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 727171005  80 -----IYTAQEaevyarmAHAAGANGFVNKGSSLAELLQAIEQV 118
Cdd:COG4567   83 tgyasIATAVE-------AIKLGADDYLAKPADADDLLAALERA 119
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 33-119 1.66e-09

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 53.50  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  33 AQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--RYPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAE 110
Cdd:cd19923   31 AEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRAdgALSHLPVLMVTAEAKKENVIAAAQAGVNNYIVKPFTAAT 110


                 ....*....
gi 727171005 111 LLQAIEQVL 119
Cdd:cd19923  111 LKEKLEKIF 119
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 5-119 2.43e-09

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 53.05  E-value: 2.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--RYPQQPILIYT 82
Cdd:cd19937    1 LVVDDEEDIVELLKYNLEKEG--YEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSdpKTSSIPIIMLT 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd19937   79 AKGEEFDKVLGLELGADDYITKPFSPRELLARVKAVL 115
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
 50-120 3.13e-09

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 52.72  E-value: 3.13e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA-QEAEvYARMAHAAGANGFVNKGSSLAELLQAIEQVLD 120
Cdd:cd17536   48 IVITDIRMPGMDGLELIEKIRELYPDIKIIILSGyDDFE-YAQKAIRLGVVDYLLKPVDEEELEEALEKAKE 118
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 2-104 3.36e-09

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 52.44  E-value: 3.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   2 PSLLLVDDHPVVHVALEAALmkSSRPY-RLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQ--PI 78
Cdd:cd17551    1 MRILIVDDNPTNLLLLEALL--RSAGYlEVVSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEdvPI 78

                         90       100
                 ....*....|....*....|....*.
gi 727171005  79 LIYTAQEAEVYARMAHAAGANGFVNK 104
Cdd:cd17551   79 VMITADTDREVRLRALEAGATDFLTK 104
MalT COG2909
ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];
152-199 3.37e-09

ATP-, maltotriose- and DNA-dependent transcriptional regulator MalT [Transcription];


Pssm-ID: 442153 [Multi-domain]  Cd Length: 184  Bit Score: 53.94  E-value: 3.37e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 727171005 152 LLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELVAVFKEL 199
Cdd:COG2909  133 LLAEGLSNKEIAERLFISVNTVKTHLRNIYRKLGVRSRTEAVARAREL 180
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
 4-119 7.79e-09

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 51.58  E-value: 7.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:cd17615    2 VLVVDDEPNITELLSMALRYEG--WDVETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFLTA 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727171005  84 QEAeVYARMAH-AAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17615   80 KDS-VEDRIAGlTAGGDDYVTKPFSLEEVVARLRALL 115
PRK15479 PRK15479
transcriptional regulator TctD;
4-111 8.91e-09

transcriptional regulator TctD;


Pssm-ID: 185376 [Multi-domain]  Cd Length: 221  Bit Score: 53.19  E-value: 8.91e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:PRK15479   3 LLLAEDNRELAHWLEKAL--VQNGFAVDCVFDGLAADHLLQSEMYALAVLDINMPGMDGLEVLQRLRKRGQTLPVLLLTA 80

                         90       100
                 ....*....|....*....|....*...
gi 727171005  84 QEAEVYARMAHAAGANGFVNKGSSLAEL 111
Cdd:PRK15479  81 RSAVADRVKGLNVGADDYLPKPFELEEL 108
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 4-83 9.41e-09

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 50.90  E-value: 9.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGLTEEG--YAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLTA 78
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
 4-120 1.05e-08

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 51.34  E-value: 1.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPIL---- 79
Cdd:cd17550    1 ILIVDDEEDIRESLSGIL--EDEGYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVImisg 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 727171005  80 ---IYTAQEAevyARMahaaGANGFVNKGSSLAELLQAIEQVLD 120
Cdd:cd17550   79 hgtIETAVKA---TKL----GAYDFIEKPLSLDRLLLTIERALE 115
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
 5-104 1.79e-08

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 50.24  E-value: 1.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIrRRYPQQPILIYTAQ 84
Cdd:cd17620    2 LVIEDEPQIRRFLRTAL--EAHGYRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRL-REWSAVPVIVLSAR 78

                         90       100
                 ....*....|....*....|
gi 727171005  85 EAEVYARMAHAAGANGFVNK 104
Cdd:cd17620   79 DEESDKIAALDAGADDYLTK 98
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-116 2.72e-08

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 51.50  E-value: 2.72e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSL--LLVDDHPVVHVALEAALMKSSrpYRLQA-AQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPqQP 77
Cdd:COG3707    1 MRGLrvLVVDDEPLRRADLREGLREAG--YEVVAeAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERP-AP 77

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 727171005  78 ILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIE 116
Cdd:COG3707   78 VILLTAYSDPELIERALEAGVSAYLVKPLDPEDLLPALE 116
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 50-120 2.83e-08

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 49.96  E-value: 2.83e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLD 120
Cdd:cd19930   47 VAILDIEMPGRTGLEVAAELREELPDTKVLIVTTFGRPGYFRRALAAGVDGYVLKDRPIEELADAIRTVHA 117
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
 4-119 8.73e-08

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 48.92  E-value: 8.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRFEG--YEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTA 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727171005  84 QEaEVYARMAH-AAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17627   79 RD-SVSDRVAGlDAGADDYLVKPFALEELLARVRALL 114
PRK15115 PRK15115
response regulator GlrR; Provisional
 3-119 9.22e-08

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 51.38  E-value: 9.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:PRK15115   7 HLLLVDDDPGLLKLLGMRL--TSEGYSVVTAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVIILT 84

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:PRK15115  85 AHGSIPDAVAATQQGVFSFLTKPVDRDALYKAIDDAL 121
PRK10610 PRK10610
chemotaxis protein CheY;
4-120 1.07e-07

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 48.82  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAaLMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--RYPQQPILIY 81
Cdd:PRK10610   8 FLVVDDFSTMRRIVRN-LLKELGFNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRAdgAMSALPVLMV 86

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 727171005  82 TAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLD 120
Cdd:PRK10610  87 TAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFE 125
PRK11475 PRK11475
DNA-binding transcriptional activator BglJ; Provisional
 61-185 1.27e-07

DNA-binding transcriptional activator BglJ; Provisional


Pssm-ID: 236915 [Multi-domain]  Cd Length: 207  Bit Score: 49.74  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  61 DGLQLLKKIRRRYPQQPILIYTAQEAEvyARMAHA---AGANGFVNKGSSLAELLQAIEQVLDGETHFPAAALAEEAPTA 137
Cdd:PRK11475  54 EGLSCLTELAIKFPRMRRLVIADDDIE--ARLIGSlspSPLDGVLSKASTLEILQQELFLSLNGVRQATDRLNNQWYINQ 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 727171005 138 DGgLLTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTG 185
Cdd:PRK11475 132 SR-MLSPTEREILRFMSRGYSMPQIAEQLERNIKTIRAHKFNVMSKLG 178
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
 4-115 1.32e-07

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 48.23  E-value: 1.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIR---RRYPQQPILI 80
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLLEKLG--YEVDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIReleGGGRRTPIIA 78

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727171005  81 YTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAI 115
Cdd:cd17546   79 LTANALEEDREKCLEAGMDDYLSKPVKLDQLKEVL 113
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
4-119 1.51e-07

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 50.62  E-value: 1.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:PRK11361   7 ILIVDDEDNVRRMLSTAFALQG--FETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVILMTA 84

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727171005  84 QeAEV-YARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:PRK11361  85 Y-AEVeTAVEALRCGAFDYVIKPFDLDELNLIVQRAL 120
PRK04841 PRK04841
HTH-type transcriptional regulator MalT;
142-199 1.89e-07

HTH-type transcriptional regulator MalT;


Pssm-ID: 235315 [Multi-domain]  Cd Length: 903  Bit Score: 50.33  E-value: 1.89e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727171005 142 LTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELVAVFKEL 199
Cdd:PRK04841 839 LTQREWQVLGLIYSGYSNEQIAGELDVAATTIKTHIRNLYQKLGIAHRQEAVQHAQDL 896
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
 4-104 3.43e-07

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 46.73  E-value: 3.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKssRPYRLQAAQDDVQALALLAE-AAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:cd18160    2 ILLADDEPSVRKFIVTTLKK--AGYAVTEAESGAEALEKLQQgKDIDIVVTDIVMPEMDGIELAREARKIDPDVKILFIS 79

                         90       100
                 ....*....|....*....|..
gi 727171005  83 AQEAEVYARMAHAAGANGFVNK 104
Cdd:cd18160   80 GGAAAAPELLSDAVGDNATLKK 101
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 5-119 5.19e-07

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 46.47  E-value: 5.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHP----VVHVALEAAlmkssrPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--RYPQQPI 78
Cdd:cd17618    4 LIVEDEPaireMIAFNLERA------GFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRdeMTRDIPI 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 727171005  79 LIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17618   78 IMLTARGEEEDKVRGLEAGADDYITKPFSPRELVARIKAVL 118
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 5-115 5.35e-07

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 46.67  E-value: 5.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRyPQQPILIYTAQ 84
Cdd:cd17594    3 LVVDDDAAMRHLLILYL--RERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRAR-SDVPIIIISGD 79

                         90       100       110
                 ....*....|....*....|....*....|..
gi 727171005  85 EAEVYAR-MAHAAGANGFVNKGSSLAELLQAI 115
Cdd:cd17594   80 RRDEIDRvVGLELGADDYLAKPFGLRELLARV 111
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 2-117 5.44e-07

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 46.43  E-value: 5.44e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   2 PSLLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIY 81
Cdd:cd17555    1 ATILVIDDDEVVRESIAAYL--EDSGFQVLQAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVV 78

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727171005  82 TAQEAEVYARMAHAAGANGFVNKG-SSLAELLQAIEQ 117
Cdd:cd17555   79 SGAGVMSDAVEALRLGAWDYLTKPiEDLAVLEHAVRR 115
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
 50-119 5.48e-07

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 46.60  E-value: 5.48e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRYpQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17622   47 AVLLDIMLPGIDGLTLCRDLRPKY-QGPILLLTALDSDIDHILGLELGADDYVVKPVEPAVLLARLRALL 115
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
 4-84 6.74e-07

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 45.83  E-value: 6.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--RYPQQPILIY 81
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYL--EDQGFTVIAASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKnaDFDTIPVIFL 78


                 ...
gi 727171005  82 TAQ 84
Cdd:cd19927   79 TAK 81
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
 5-115 6.93e-07

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 46.30  E-value: 6.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQ--PILIYT 82
Cdd:cd17580    2 LVVDDNEDAAEMLALLL--ELEGAEVTTAHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLRELPWLAntPAIALT 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELLQAI 115
Cdd:cd17580   80 GYGQPEDRERALEAGFDAHLVKPVDPDELIELI 112
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
 2-114 7.99e-07

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 45.90  E-value: 7.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   2 PSLLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIY 81
Cdd:cd17563    1 KSLLLVDDDEVFAERLARAL--ERRGFEVETAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVVL 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 727171005  82 TAqeaevYARMAHA-----AGANGFVNKGSSLAELLQA 114
Cdd:cd17563   79 TG-----YASIATAveaikLGADDYLAKPADADEILAA 111
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 50-119 8.79e-07

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 46.12  E-value: 8.79e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA--QEAEVyaRMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17542   48 LVTMDITMPEMDGIEALKEIKKIDPNAKVIMCSAmgQEEMV--KEAIKAGAKDFIVKPFQPERVLEAVEKVL 117
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
 2-74 1.02e-06

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 45.86  E-value: 1.02e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727171005   2 PSLLLVDDHPVVHVALEAALMKSsrPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYP 74
Cdd:cd17569    1 PTILLVDDEPNILKALKRLLRRE--GYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYP 71
PRK10100 PRK10100
transcriptional regulator CsgD;
50-194 1.20e-06

transcriptional regulator CsgD;


Pssm-ID: 182241 [Multi-domain]  Cd Length: 216  Bit Score: 47.17  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRYPQQP--ILIYTAQEAEvYARMAHAAGANGFVNKGSSLAELLQAIEQVLDGETHFPA 127
Cdd:PRK10100  55 IILLDMMEADKKLIHYWQDTLSRKNNNIkiLLLNTPEDYP-YREIENWPHINGVFYAMEDQERVVNGLQGVLRGECYFTQ 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727171005 128 AALAEE--------APTADGGLLTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGNLLELVA 194
Cdd:PRK10100 134 KLASYLithsgnyrYNSTESALLTHREKEILNKLRIGASNNEIARSLFISENTVKTHLYNLFKKIAVKNRTQAVS 208
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
 1-88 1.30e-06

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 47.26  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHP----VVHVALEAALMKSSRPYRLQAAQDDVQALAllaeaaFGLVILDIGLPQVDGLQLLKKIRRRYPQQ 76
Cdd:PRK11083   3 QPTILLVEDEQaiadTLVYALQSEGFTVEWFERGLPALDKLRQQP------PDLVILDVGLPDISGFELCRQLLAFHPAL 76

                         90
                 ....*....|..
gi 727171005  77 PILIYTAQEAEV 88
Cdd:PRK11083  77 PVIFLTARSDEV 88
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
3-83 1.88e-06

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 47.81  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005    3 SLLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:PRK09959  960 SILIADDHPTNRLLLKRQL--NLLGYDVDEATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQNSSLPIWGLT 1037


                  .
gi 727171005   83 A 83
Cdd:PRK09959 1038 A 1038
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
 2-83 2.00e-06

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 44.96  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   2 PSLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAafGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIY 81
Cdd:cd19919    1 KTVWIVDDDSSIRWVLERALAGAGLTVTSFENAQEALAALASSQP--DVLISDIRMPGMDGLALLAQIKQRHPDLPVIIM 78


                 ..
gi 727171005  82 TA 83
Cdd:cd19919   79 TA 80
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
4-119 2.47e-06

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 46.95  E-value: 2.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHpVVHVALEAALMKSsRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:PRK10365   8 ILVVDDD-ISHCTILQALLRG-WGYNVALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMTA 85

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 727171005  84 QEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:PRK10365  86 YSSVETAVEALKTGALDYLIKPLDFDNLQATLEKAL 121
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
 4-105 2.91e-06

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 44.29  E-value: 2.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQ---------ALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--R 72
Cdd:cd19924    1 ILVVDDSPTARKQLRDLL--KNLGFEIAEAVDGEEalnklenlaKEGNDLSKELDLIITDIEMPKMDGYELTFELRDdpR 78

                         90       100       110
                 ....*....|....*....|....*....|...
gi 727171005  73 YPQQPILIYTAQEAEVYARMAHAAGANGFVNKG 105
Cdd:cd19924   79 LANIPVILNSSLSGEFSRARGKKVGADAYLAKF 111
PRK10336 PRK10336
two-component system response regulator QseB;
4-187 3.34e-06

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 46.04  E-value: 3.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:PRK10336   3 ILLIEDDMLIGDGIKTGLSKMG--FSVDWFTQGRQGKEALYSAPYDAVILDLTLPGMDGRDILREWREKGQREPVLILTA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  84 QEAEVYARMAHAAGANGFVNKGSSLAEL---LQAIEQVLDGET-----HFPAAALAEEAPTADGG---LLTPKELEVLGL 152
Cdd:PRK10336  81 RDALAERVEGLRLGADDYLCKPFALIEVaarLEALMRRTNGQAsnelrHGNVMLDPGKRIATLAGeplTLKPKEFALLEL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 727171005 153 LSQG----LSNLQIADRLH-----ISNKTVSTHKKNIQRKTGAG 187
Cdd:PRK10336 161 LMRNagrvLPRKLIEEKLYtwdeeVTSNAVEVHVHHLRRKLGSD 204
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
 50-119 3.47e-06

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 44.29  E-value: 3.47e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRYpQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd19939   46 LVVLDIMLPGMDGLTVCREVREHS-HVPILMLTARTEEMDRVLGLEMGADDYLCKPFSPRELLARVRALL 114
PRK11517 PRK11517
DNA-binding response regulator HprR;
4-112 4.19e-06

DNA-binding response regulator HprR;


Pssm-ID: 183172 [Multi-domain]  Cd Length: 223  Bit Score: 45.66  E-value: 4.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYpQQPILIYTA 83
Cdd:PRK11517   3 ILLIEDNQRTQEWVTQGLSEAG--YVIDAVSDGRDGLYLALKDDYALIILDIMLPGMDGWQILQTLRTAK-QTPVICLTA 79

                         90       100
                 ....*....|....*....|....*....
gi 727171005  84 QEAEVYARMAHAAGANGFVNKGSSLAELL 112
Cdd:PRK11517  80 RDSVDDRVRGLDSGANDYLVKPFSFSELL 108
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
 4-119 4.98e-06

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 43.83  E-value: 4.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRyPQQPILIYTA 83
Cdd:cd17623    1 ILLIDDDRELTELLTEYL--EMEGFNVRAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKT-SQVPVLMLTA 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 727171005  84 QEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17623   78 RGDDIDRILGLELGADDYLPKPFNPRELVARIRAIL 113
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
 5-120 5.04e-06

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 44.02  E-value: 5.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQ 84
Cdd:cd17549    2 LLVDDDADVREALQQTLELAG--FRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVILITGH 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 727171005  85 eAEVyaRMAHAA---GANGFVNKGSSLAELLQAIEQVLD 120
Cdd:cd17549   80 -GDV--PMAVEAmraGAYDFLEKPFDPERLLDVVRRALE 115
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
 4-83 8.07e-06

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 43.34  E-value: 8.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:cd17572    1 VLLVEDSPSLAALYQEYL--SDEGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITA 78
rcsA PRK15411
transcriptional regulator RcsA;
142-188 1.12e-05

transcriptional regulator RcsA;


Pssm-ID: 185309 [Multi-domain]  Cd Length: 207  Bit Score: 44.35  E-value: 1.12e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 727171005 142 LTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGN 188
Cdd:PRK15411 138 LSRTESSMLRMWMAGQGTIQISDQMNIKAKTVSSHKGNIKRKIKTHN 184
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
 4-119 1.13e-05

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 43.11  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALeAALMKSSRPYRLQA-AQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:cd19931    1 VLLIDDHPLLRKGI-KQLIELDPDFTVVGeASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILT 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd19931   80 VSDAEDDVVTALRAGADGYLLKDMEPEDLLEALKQAA 116
ompR PRK09468
osmolarity response regulator; Provisional
 4-119 1.21e-05

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 44.58  E-value: 1.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:PRK09468   8 ILVVDDDMRLRALLERYL--TEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNNPTPIIMLTA 85

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 727171005  84 QEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:PRK09468  86 KGEEVDRIVGLEIGADDYLPKPFNPRELLARIRAVL 121
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
 5-104 1.52e-05

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 42.14  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQ 84
Cdd:cd19926    2 LVVDDEPDIRELLEITLGRMG--LDVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVITAY 79

                         90       100
                 ....*....|....*....|
gi 727171005  85 EAEVYARMAHAAGANGFVNK 104
Cdd:cd19926   80 GSLDTAIEALKAGAFDFLTK 99
PRK10766 PRK10766
two-component system response regulator TorR;
3-112 1.54e-05

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 43.87  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIyT 82
Cdd:PRK10766   4 HILVVEDEPVTRARLQGYFEQEG--YTVSEAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSRSTVGIILV-T 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 727171005  83 AQEAEVYARMAHAAGANGFVNKGSSLAELL 112
Cdd:PRK10766  81 GRTDSIDRIVGLEMGADDYVTKPLELRELL 110
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
 6-104 2.13e-05

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 41.66  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   6 LVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRyPQQPILIYTAQE 85
Cdd:cd19936    3 LVDDDRNILTSVSMAL--EAEGFSVETYTDGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQK-STLPVIFLTSKD 79

                         90
                 ....*....|....*....
gi 727171005  86 AEVYARMAHAAGANGFVNK 104
Cdd:cd19936   80 DEIDEVFGLRMGADDYITK 98
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
 50-119 2.75e-05

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 44.09  E-value: 2.75e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:PRK10923  50 VLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMTAHSDLDAAVSAYQQGAFDYLPKPFDIDEAVALVERAI 119
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 4-104 3.01e-05

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 41.33  E-value: 3.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIR--RRYPQQPILIY 81
Cdd:cd17538    2 ILVVDDEPANRELLEALL--SAEGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKedPETRHIPVIMI 79

                         90       100
                 ....*....|....*....|....*.
gi 727171005  82 TA---QEAEVyarMAHAAGANGFVNK 104
Cdd:cd17538   80 TAlddREDRI---RGLEAGADDFLSK 102
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 4-116 3.06e-05

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 41.63  E-value: 3.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALeAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPqQPILIYTA 83
Cdd:cd19932    3 VLIAEDEALIRMDL-REMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENI-APIVLLTA 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 727171005  84 QEAEVYARMAHAAGANGFVNKGSSLAELLQAIE 116
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVKPFSESDLIPAIE 113
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 50-119 4.77e-05

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 41.21  E-value: 4.77e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  50 LVILDIGLPQVDGLQLLKKIrRRYPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd19938   46 LILLDLMLPGTDGLTLCREI-RRFSDVPIIMVTARVEEIDRLLGLELGADDYICKPYSPREVVARVKAIL 114
COG1356 COG1356
Transcriptional regulator [Transcription];
140-182 5.23e-05

Transcriptional regulator [Transcription];


Pssm-ID: 440967 [Multi-domain]  Cd Length: 139  Bit Score: 41.38  E-value: 5.23e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 727171005 140 GLLTPKELEVLGLLSQGLSNLQIADRLHISNKTVST----HKKNIQR 182
Cdd:COG1356    7 SLLTRRQAEVLALRERGLTQQEIADILGTSRANVSSieksARENIEK 53
PRK10710 PRK10710
DNA-binding transcriptional regulator BaeR; Provisional
 50-183 5.61e-05

DNA-binding transcriptional regulator BaeR; Provisional


Pssm-ID: 182665 [Multi-domain]  Cd Length: 240  Bit Score: 42.36  E-value: 5.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  50 LVILDIGLPQVDGLQLLKKIrRRYPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVLD--GETHFPA 127
Cdd:PRK10710  57 LILLDLMLPGTDGLTLCREI-RRFSDIPIVMVTAKIEEIDRLLGLEIGADDYICKPYSPREVVARVKTILRrcKPQRELQ 135

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727171005 128 AALAEEAPTADGGL-----------LTPKELEVLGLLSQG----LSNLQIADRLH-----ISNKTVSTHKKNIQRK 183
Cdd:PRK10710 136 QQDAESPLIIDESRfqaswrgkmldLTPAEFRLLKTLSHEpgkvFSREQLLNHLYddyrvVTDRTIDSHIKNLRRK 211
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-119 5.80e-05

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 42.50  E-value: 5.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHPVVHVALEAALMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILI 80
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 727171005  81 YTAQEAevYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:COG3279   81 TTAYDE--YALEAFEVNAVDYLLKPIDEERLAKALEKAK 117
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
 50-111 6.09e-05

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 40.84  E-value: 6.09e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRYPqQPILI---YTAQEAEVYARmAHAAGANGFVNKGSSLAEL 111
Cdd:cd17541   49 VITLDIEMPVMDGLEALRRIMAERP-TPVVMvssLTEEGAEITLE-ALELGAVDFIAKPSGGISL 111
orf27 CHL00148
Ycf27; Reviewed
 4-119 7.35e-05

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 42.01  E-value: 7.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALmkSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRyPQQPILIYTA 83
Cdd:CHL00148   9 ILVVDDEAYIRKILETRL--SIIGYEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIRKE-SDVPIIMLTA 85

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727171005  84 QEaEVYAR-MAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:CHL00148  86 LG-DVSDRiTGLELGADDYVVKPFSPKELEARIRSVL 121
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
 48-119 1.05e-04

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 40.27  E-value: 1.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727171005  48 FGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd17537   45 PGCLVLDVRMPGMSGLELQDELLARGSNIPIIFITGHGDVPMAVEAMKAGAVDFLEKPFRDQVLLDAIEQAL 116
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
 50-104 1.06e-04

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 39.79  E-value: 1.06e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQEAEVYARMAHAAGANGFVNK 104
Cdd:cd19928   45 LVITDVVMPDENGLDLIPRIKKARPDLPIIVMSAQNTLMTAVKAAERGAFEYLPK 99
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
 50-104 1.72e-04

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 39.81  E-value: 1.72e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRYPQQP---ILIYTAQEAEVYARMAHaAGANGFVNK 104
Cdd:cd17544   48 LVITDYNMPEMDGFELVREIRKKYSRDQlaiIGISASGDNALSARFIK-AGANDFLTK 104
PRK10816 PRK10816
two-component system response regulator PhoP;
52-119 1.75e-04

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 40.88  E-value: 1.75e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727171005  52 ILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:PRK10816  49 IVDLGLPDEDGLSLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALM 116
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
 50-119 1.88e-04

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 39.57  E-value: 1.88e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  50 LVILDIGLPQVDGLQLLKKIRRRyPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:cd18159   45 LVLLDINLPYFDGFYWCREIRQI-SNVPIIFISSRDDNMDQVMAINMGGDDYITKPFDLDVLLAKIKAIL 113
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
 5-117 2.46e-04

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 39.06  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPV----VHVALEAAlmkssrPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--RYPQQPI 78
Cdd:cd17548    3 LIVEDNPLnmklARDLLESA------GYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKEdpATRDIPV 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 727171005  79 LIYTAqeaevYArM------AHAAGANGFVNKGSSLAELLQAIEQ 117
Cdd:cd17548   77 IALTA-----YA-MkgdrekILEAGCDGYISKPIDTREFLETVAK 115
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
 50-112 3.80e-04

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 40.17  E-value: 3.80e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727171005  50 LVILDIGLPQVDGLQLLKKIrRRYPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELL 112
Cdd:PRK10529  48 LIILDLGLPDGDGIEFIRDL-RQWSAIPVIVLSARSEESDKIAALDAGADDYLSKPFGIGELQ 109
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
5-118 3.99e-04

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 40.25  E-value: 3.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   5 LLVDDHPVVHVALEAALmkSSRP-YR-LQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPqQPILIYT 82
Cdd:PRK12555   4 GIVNDSPLAVEALRRAL--ARDPdHEvVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAERP-CPILIVT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 727171005  83 A---QEAE-VYARMAHaaGANGFVNK-----GSSL----AELLQAIEQV 118
Cdd:PRK12555  81 SlteRNASrVFEAMGA--GALDAVDTptlgiGAGLeeyaAELLAKIDQI 127
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 4-117 6.11e-04

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 39.82  E-value: 6.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSsrPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:PRK13558  10 VLFVGDDPEAGPVDCDLDEDG--RLDVTQIRDFVAARDRVEAGEIDCVVADHEPDGFDGLALLEAVRQTTAVPPVVVVPT 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 727171005  84 QEAEVYARMAHAAGANGFVNKGSS--LAELLQAIEQ 117
Cdd:PRK13558  88 AGDEAVARRAVDADAAAYVPAVSDdaTAAIAERIES 123
PRK10188 PRK10188
transcriptional regulator SdiA;
145-188 8.38e-04

transcriptional regulator SdiA;


Pssm-ID: 182292 [Multi-domain]  Cd Length: 240  Bit Score: 39.00  E-value: 8.38e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 727171005 145 KELEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRKTGAGN 188
Cdd:PRK10188 183 REKEILKWTAEGKTSAEIAMILSISENTVNFHQKNMQKKFNAPN 226
Sig70_bacteroi1 TIGR02985
RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors ...
 155-179 1.04e-03

RNA polymerase sigma-70 factor, Bacteroides expansion family 1; This group of sigma factors are members of the sigma-70 family (TIGR02937) and are found primarily in the genus Bacteroides. This family appears to have resulted from a lineage-specific expansion as B. thetaiotaomicron VPI-5482, Bacteroides forsythus ATCC 43037, Bacteroides fragilis YCH46 and Bacteroides fragilis NCTC 9343 contain 25, 12, 24 and 23 members, respectively. There are currentlyonly two known members of this family outside of the Bacteroides, in Rhodopseudomonas and Bradyrhizobium.


Pssm-ID: 274376 [Multi-domain]  Cd Length: 161  Bit Score: 38.31  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*
gi 727171005  155 QGLSNLQIADRLHISNKTVSTHKKN 179
Cdd:TIGR02985 128 EGLSNKEIAEELGISVKTVEYHITK 152
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
 3-115 1.04e-03

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 37.77  E-value: 1.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALMKSSRpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRR--YPQQPILI 80
Cdd:cd17575    2 MVLLVDDQAIIGEAVRRALADEED-IDFHYCSDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFRANpaTRDIPIIV 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727171005  81 YTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAI 115
Cdd:cd17575   81 LSTKEEPEVKSEAFALGANDYLVKLPDKIELVARI 115
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
 7-104 1.08e-03

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 36.96  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   7 VDDHPVVHVALEAALMKssRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRR--RYPQQPILIYTAQ 84
Cdd:cd17602    4 VDDRPSIQKMIEYFLEK--QGFRVVVIDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRKssALKDTPIIMLTGK 81

                         90       100
                 ....*....|....*....|
gi 727171005  85 EAEVYARMAHAAGANGFVNK 104
Cdd:cd17602   82 DGLVDRIRAKMAGASGYLTK 101
REC_LytTR_AgrA-like cd17533
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; ...
 17-120 1.21e-03

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AgrA; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AgrA-like group of LytTR/AlgR family response regulators are Staphylococcus aureus accessory gene regulator protein A (AgrA) and Streptococcus pneumoniae response regulator ComE, which are members of two-component regulatory systems. AgrA is a global regulator that controls the synthesis of virulence factors and other exoproteins. ComE is part of the ComD-ComE system that is part of a quorum-sensing signaling pathway that controls the development of competence, a physiological state required for genetic transformation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381088 [Multi-domain]  Cd Length: 131  Bit Score: 37.60  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005  17 LEAALMKSSRPYRLQ---AAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQEAEVYARMA 93
Cdd:cd17533   20 IENILKIENIEYVIEltgKTEELLEKIKERGKNGIYFLDIDIKMEEKNGLEVAQKIRKYDPYAIIIFVTTHSEFAPLTFE 99

                         90       100
                 ....*....|....*....|....*..
gi 727171005  94 HAAGANGFVNKGSSLAELLQAIEQVLD 120
Cdd:cd17533  100 YKVAALDFILKPLKLEEFKKRIEECIK 126
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
1-119 1.26e-03

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 38.63  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   1 MPSLLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAaFGLVILDIGLPQVDGLQLLKKIRRRYpQQPILI 80
Cdd:PRK10955   1 MNKILLVDDDRELTSLLKELLEMEG--FNVIVAHDGEQALDLLDDS-IDLLLLDVMMPKKNGIDTLKELRQTH-QTPVIM 76

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 727171005  81 YTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:PRK10955  77 LTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAIL 115
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 6-83 2.54e-03

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 36.45  E-value: 2.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727171005   6 LVDDHPVVHVALEAALMKSSRPYrLQAAQDDvqalallaeaafgLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:cd19925   19 YVEQVPGFTVIGTAGTGEEALKL-LKERQPD-------------LILLDIYLPDGNGLDLLRELRAAGHDVDVIVVTA 82
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
 3-118 3.13e-03

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 35.98  E-value: 3.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   3 SLLLVDDHPVVHVALEAALMKSSrPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRR-YPQQPILIY 81
Cdd:cd17593    2 KVLICDDSSMARKQLARALPADW-DVEITFAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEqLETKVIVVS 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727171005  82 TAQEAEVYARMAhAAGANGFVNKGSSLAELLQAIEQV 118
Cdd:cd17593   81 GDVQPEAKERVL-ELGALAFLKKPFDPEKLAQLLEEL 116
REC_ETR-like cd19933
phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and ...
 48-111 3.43e-03

phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins; Plant ethylene receptors contain N-terminal transmembrane domains that contain an ethylene binding site and also serve in localization of the receptor to the endoplasmic reticulum or the Golgi apparatus and a C-terminal histidine kinase (HK)-like domain. There are five ethylene receptors (ETR1, ERS1, ETR2, ERS2, and EIN4) in Arabidopsis thaliana. ETR1, ETR2, and EIN4 also contain REC domains C-terminal to the HK domain. ETR1 and ERS1 belong to subfamily 1, and have functional HK domains while ETR2, ERS2, and EIN4 belong to subfamily 2, and lack the necessary residues for HK activity and may function as serine/threonine kinases. The plant hormone ethylene plays an important role in plant growth and development. It regulates seed germination, seedling growth, leaf and petal abscission, fruit ripening, organ senescence, and pathogen responses. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381160 [Multi-domain]  Cd Length: 117  Bit Score: 35.84  E-value: 3.43e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727171005  48 FGLVILDIGLPQVDGLQLLKKIRRRYP--QQPILIYTAQEAEVYAR-MAHAAGANGFVNKGSSLAEL 111
Cdd:cd19933   47 FQLVLLDLCMPEMDGFEVALRIRKLFGrrERPLIVALTANTDDSTReKCLSLGMNGVITKPVSLHAL 113
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
 4-82 3.48e-03

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 35.85  E-value: 3.48e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727171005   4 LLLVDDHPVVHVALEaaLMKSSRPYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYT 82
Cdd:cd17616    1 VLLIEDDSATAQSIE--LMLKSEGFNVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTLRLAKVKTPILILS 77
PRK13557 PRK13557
histidine kinase; Provisional
 61-123 4.08e-03

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 37.34  E-value: 4.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727171005  61 DGLQLLKKIRRRYPQQPILIYTAqeaevYARMA---HAAGANGF--VNKGSSLAELLQAIEQVLDGET 123
Cdd:PRK13557 475 NGVMLAREARRRQPKIKVLLTTG-----YAEASierTDAGGSEFdiLNKPYRRAELARRVRMVLDGPT 537
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
 50-104 4.52e-03

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 35.28  E-value: 4.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 727171005  50 LVILDIGLPQVDGLQLLKKIR--RRYPQQPILIYTAQEAEVYARMAHAAGANGFVNK 104
Cdd:cd17561   50 VLLLDIIMPHLDGIGVLEKLRrmRLEKRPKIIMLTAFGQEDITQRAVELGASYYILK 106
PRK09836 PRK09836
DNA-binding transcriptional activator CusR; Provisional
 48-119 4.91e-03

DNA-binding transcriptional activator CusR; Provisional


Pssm-ID: 182102 [Multi-domain]  Cd Length: 227  Bit Score: 36.83  E-value: 4.91e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727171005  48 FGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIEQVL 119
Cdd:PRK09836  45 YDLIILDIMLPDVNGWDIVRMLRSANKGMPILLLTALGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLL 116
PRK15347 PRK15347
two component system sensor kinase;
48-116 5.57e-03

two component system sensor kinase;


Pssm-ID: 237951 [Multi-domain]  Cd Length: 921  Bit Score: 37.31  E-value: 5.57e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727171005  48 FGLVILDIGLPQVDGLQLLKKIRR----RYPQQPILIYTAQEAEVYARMAHAAGANGFVNKGSSLAELLQAIE 116
Cdd:PRK15347 735 FDLVLMDIRMPGLDGLETTQLWRDdpnnLDPDCMIVALTANAAPEEIHRCKKAGMNHYLTKPVTLAQLARALE 807
tfx PRK03975
putative transcriptional regulator; Provisional
 140-193 8.11e-03

putative transcriptional regulator; Provisional


Pssm-ID: 179690 [Multi-domain]  Cd Length: 141  Bit Score: 35.25  E-value: 8.11e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727171005 140 GLLTPKELEVLGLLSQGLSNLQIADRLHISNKTVSTHKK----NIQRktgAGNLLELV 193
Cdd:PRK03975   5 SFLTERQIEVLRLRERGLTQQEIADILGTSRANVSSIEKrareNIEK---ARETLAFA 59
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
147-183 8.91e-03

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 36.00  E-value: 8.91e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 727171005 147 LEVLGLLSQGLSNLQIADRLHISNKTVSTHKKNIQRK 183
Cdd:COG3677   66 LQAIRLLLNGISLRQIARVLGVSYKTVWRWLHRIREA 102
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
 4-96 9.28e-03

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 34.84  E-value: 9.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727171005   4 LLLVDDHPVVHVALEAALMKSSrpYRLQAAQDDVQALALLAEAAFGLVILDIGLPQVDGLQLLKKIRRRYPQQPILIYTA 83
Cdd:cd17553    3 ILIVDDQYGIRILLNEVFNKEG--YQTFQAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTA 80

                         90       100
                 ....*....|....*....|
gi 727171005  84 -------QEAEVYARMAHAA 96
Cdd:cd17553   81 ygeldmiQESKELGALTHFA 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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