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Conserved domains on  [gi|727170253|ref|WP_033638258|]
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MULTISPECIES: histidine utilization repressor [Serratia]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11493457)

GntR family transcriptional regulator such as the histidine utilization repressor HutC, a repressor which binds to the hutP region in the histidine utilization (hut) operon

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 20-249 7.44e-128

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


:

Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 361.25  E-value: 7.44e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253   20 PIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLEVHNI 99
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  100 ADEIAARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRVTPYT 179
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  180 YLTQAAPLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHRRTWSGKTVVTSARLLYPGSRYQLFGRFTS 249
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGRFTP 230
 
Name Accession Description Interval E-value
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 20-249 7.44e-128

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 361.25  E-value: 7.44e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253   20 PIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLEVHNI 99
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  100 ADEIAARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRVTPYT 179
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  180 YLTQAAPLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHRRTWSGKTVVTSARLLYPGSRYQLFGRFTS 249
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGRFTP 230
PRK14999 PRK14999
histidine utilization repressor; Provisional
 17-249 2.10e-110

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 317.64  E-value: 2.10e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  17 APAPIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLEV 96
Cdd:PRK14999   9 APAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  97 HNIADEIAARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRVT 176
Cdd:PRK14999  89 RSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLTQDYRQTT 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727170253 177 PYTYLTQAAPLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHRRTWSGKTVVTSARLLYPGSRYQLFGRFTS 249
Cdd:PRK14999 169 PHAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFIS 241
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
16-250 3.71e-78

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 235.53  E-value: 3.71e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  16 DAPAPIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLE 95
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  96 VHNIADEIAARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRV 175
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727170253 176 TPYTYLTQAA--PLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHRRTWS-GKTVVTSARLLYPGSRYQLFGRFTSE 250
Cdd:COG2188  161 SLYELLEERYglRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDaDGRPVEYSRSYYRGDRYRFVVELRRR 238
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 105-242 1.80e-35

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 123.48  E-value: 1.80e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  105 ARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRVTPYTYLTQA 184
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727170253  185 --APLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHRRTWSGK-TVVTSARLLYPGSRYQ 242
Cdd:pfam07702  81 ygLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDgRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 105-242 1.57e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 115.85  E-value: 1.57e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253   105 ARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRvTPYTYLTQ- 183
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSG-SLYEYLEEr 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727170253   184 ----AAPLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHR-RTWSGKTVVTSARLLYPGSRYQ 242
Cdd:smart00866  80 lglkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERvTYDDDGRPVEYSRSYYRGDRFR 143
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 20-85 1.01e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 90.58  E-value: 1.01e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727170253  20 PIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVA 85
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
his_ut_repres TIGR02018
histidine utilization repressor, proteobacterial; This model represents a proteobacterial ...
 20-249 7.44e-128

histidine utilization repressor, proteobacterial; This model represents a proteobacterial histidine utilization repressor. It is usually found clustered with the enzymes HutUHIG so that it can regulate its own expression as well. A number of species have several paralogs and may fine-tune the regulation according to levels of degradation intermediates such as urocanate. This family belongs to the larger GntR family of transcriptional regulators. [Energy metabolism, Amino acids and amines, Regulatory functions, DNA interactions]


Pssm-ID: 188194 [Multi-domain]  Cd Length: 230  Bit Score: 361.25  E-value: 7.44e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253   20 PIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLEVHNI 99
Cdd:TIGR02018   1 PLYQRIKQDILERIRSGEWPPGHRIPSEHELVAQYGCSRMTVNRALRELTDAGLLERRQGVGTFVAEPKAQSALLEIRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  100 ADEIAARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRVTPYT 179
Cdd:TIGR02018  81 ADEIVARGHRYRYELLELETRRATAEDAAALALPAGGKVFHSEIVHFENDVPFQLEDRLVNAAAVPDYLKQDFTQTTPGA 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  180 YLTQAAPLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHRRTWSGKTVVTSARLLYPGSRYQLFGRFTS 249
Cdd:TIGR02018 161 YLSQAAPLTEAEHRIEAISADPEEARLLAIDAGEPCLLIRRRTWSGAQVVTRARLLYPGSRYRLVGRFTP 230
PRK14999 PRK14999
histidine utilization repressor; Provisional
 17-249 2.10e-110

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 317.64  E-value: 2.10e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  17 APAPIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLEV 96
Cdd:PRK14999   9 APAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKGQSALFEV 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  97 HNIADEIAARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRVT 176
Cdd:PRK14999  89 RSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLTQDYRQTT 168

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727170253 177 PYTYLTQAAPLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHRRTWSGKTVVTSARLLYPGSRYQLFGRFTS 249
Cdd:PRK14999 169 PHAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFIS 241
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
16-250 3.71e-78

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 235.53  E-value: 3.71e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  16 DAPAPIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLE 95
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEPKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  96 VHNIADEIAARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRV 175
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALFPGLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727170253 176 TPYTYLTQAA--PLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHRRTWS-GKTVVTSARLLYPGSRYQLFGRFTSE 250
Cdd:COG2188  161 SLYELLEERYglRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDaDGRPVEYSRSYYRGDRYRFVVELRRR 238
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 105-242 1.80e-35

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 123.48  E-value: 1.80e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  105 ARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRVTPYTYLTQA 184
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLLEEDLEEGSLYDYLEER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727170253  185 --APLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHRRTWSGK-TVVTSARLLYPGSRYQ 242
Cdd:pfam07702  81 ygLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDgRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 105-242 1.57e-32

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 115.85  E-value: 1.57e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253   105 ARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRvTPYTYLTQ- 183
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGLLEEDLSG-SLYEYLEEr 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727170253   184 ----AAPLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHR-RTWSGKTVVTSARLLYPGSRYQ 242
Cdd:smart00866  80 lglkIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERvTYDDDGRPVEYSRSYYRGDRFR 143
PRK11402 PRK11402
transcriptional regulator PhoB;
20-240 1.66e-25

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 100.29  E-value: 1.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  20 PIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLEVHNI 99
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVENALLTVSGF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253 100 ADEIAARGHRHSSKILElKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLKQDFDRVTPYT 179
Cdd:PRK11402  89 TDFGVSQGKATKEKVIE-QERVSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDEIYVEGSSTYQ 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727170253 180 YLTQ---AAPlTAGEHIVEAVIPTRRERELLQLEDHEPGLLIHRRTW-SGKTVVTSARLLYPGSR 240
Cdd:PRK11402 168 LFQErfdTRV-VSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFdQNDKPVHVSELFCRANR 231
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 20-85 1.01e-23

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 90.58  E-value: 1.01e-23
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727170253  20 PIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVA 85
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
16-130 1.15e-21

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 86.77  E-value: 1.15e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  16 DAPAPIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLE 95
Cdd:COG1725    6 DSGVPIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEER 85

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727170253  96 VHNIADEIAARGhrhsskILELKARAASEEEATAL 130
Cdd:COG1725   86 REEFLEEALREL------VAEARRLGLSLEELLEL 114
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 22-84 5.28e-20

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 80.74  E-value: 5.28e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727170253   22 YQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFV 84
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 15-93 5.71e-19

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 85.27  E-value: 5.71e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727170253  15 SDAPAPIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTAL 93
Cdd:COG1167    7 RDSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAARLPAPAP 85
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 21-216 5.88e-18

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 80.21  E-value: 5.88e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253   21 IYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLEVHNIA 100
Cdd:TIGR02325   9 LWRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVAARRIDYPLSARTRFS 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  101 DEIAARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDyLKQDFDRVTPYTY 180
Cdd:TIGR02325  89 QNLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFPG-IGQAYAASGSITD 167

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 727170253  181 LTQA---APLTAGEHIVEAVIPTRRERELLQLEDHEPGL 216
Cdd:TIGR02325 168 ALREqgvADYRRSSTRISARHADAKDCARLELPPGRPLL 206
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
25-84 2.85e-16

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 70.68  E-value: 2.85e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253    25 VKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFV 84
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK09764 PRK09764
GntR family transcriptional regulator;
20-156 3.05e-16

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 75.25  E-value: 3.05e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  20 PIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALLEVHNI 99
Cdd:PRK09764   5 PLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEERVNYDIFQLTSF 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 727170253 100 ADEIAARGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVED 156
Cdd:PRK09764  85 DEKLSDRHVDTHSEVLIFEVIPADDFLQQQLQITAQDRVWHVKRVRYRKQKPMALEE 141
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
17-130 1.12e-15

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 73.81  E-value: 1.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  17 APAPIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAhtallev 96
Cdd:COG2186    4 RRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSP------- 76

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 727170253  97 HNIADEIAARGHRHSSKILEL-KARAASEEEATAL 130
Cdd:COG2186   77 WALLDPLALLLALDDASLRDLlEARLALEPEAARL 111
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
11-86 5.52e-09

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 54.93  E-value: 5.52e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727170253  11 AAAMSDAPAPIYQRVKQAIVNQIRAGHWQPHQRVpSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAE 86
Cdd:COG1802    2 TSPSPLRRESLAEQVYEALREAILSGELPPGERL-SEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 24-84 1.79e-08

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 53.62  E-value: 1.79e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727170253  24 RVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFV 84
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 21-227 2.57e-08

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 53.24  E-value: 2.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  21 IYQRVKQAIVNQIRAGHWqphqrVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFV----------AEAKAH 90
Cdd:PRK10079  17 IAAKLEQELRQHYRCGDY-----LPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVlmrpydyplnAQARFS 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  91 TALLEvhniadeiaaRGHRHSSKILELKARAASEEEATALGIHPGQRLFYSQIVHYENDVPVQVEDRCVNPLVAPDYLkQ 170
Cdd:PRK10079  92 QNLLD----------QGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNGVALCLIDHYFADLTWWPTL-Q 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 727170253 171 DFDRVTPYTYLTQ--AAPLTAGEHIVEAVIPTRRERELLQLEDHEPGLLIhrRTWSGKT 227
Cdd:PRK10079 161 RFDSGSLHDFLREqlGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCV--RTLNHRD 217
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
22-86 4.60e-07

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 49.63  E-value: 4.60e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727170253  22 YQRVKQ-----AIVNQ----IRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAE 86
Cdd:PRK09464   3 YSKIRQpklsdVIEQQleflILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS 76
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
 23-139 3.03e-05

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 43.97  E-value: 3.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  23 QRvKQAIVNQIRAghwqpHQRVPSEsELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTALlevhniade 102
Cdd:COG1349    5 ER-RQKILELLRE-----RGRVSVE-ELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEPPF--------- 68

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 727170253 103 iAARGHRHSskilELKARAAseEEATALgIHPGQRLF 139
Cdd:COG1349   69 -AERETLNA----EEKRAIA--RAAASL-IEDGDTIF 97
PRK10225 PRK10225
Uxu operon transcriptional regulator;
22-126 8.44e-05

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 42.70  E-value: 8.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  22 YQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTAL--LEVHNI 99
Cdd:PRK10225  11 YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLDSSGSHNTdsPDANVC 90

                         90       100       110
                 ....*....|....*....|....*....|.
gi 727170253 100 AD----EIAARGHRHSSKILELKARAASEEE 126
Cdd:PRK10225  91 NDagpfELLQARQLLESNIAEFAALQATRED 121
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 14-93 2.27e-04

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 41.29  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727170253  14 MSDAPAPIYQRVKQAIVNQIRAGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTAL 93
Cdd:PRK09990   1 MKDERRPIADVVAERIERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVARLNRVQDA 80
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
27-79 9.55e-04

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 36.43  E-value: 9.55e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 727170253    27 QAIVNQIRaghwqpHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQG 79
Cdd:smart00420   3 QQILELLA------QQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHG 49
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
49-80 1.35e-03

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 37.64  E-value: 1.35e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 727170253  49 ELVAELGVSRMTINRALRELTSEGFLIRMQGV 80
Cdd:COG3355   47 ELAEALDRSRSTVYRSLQKLLEAGLVEREKRN 78
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 29-93 2.10e-03

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 38.87  E-value: 2.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727170253  29 IVNQIR----AGHWQPHQRVPSESELVAELGVSRMTINRALRELTSEGFLIRMQGVGTFVAEAKAHTAL 93
Cdd:PRK15481  10 IFDSIRqliqAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSPSPVAL 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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