|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
15-396 |
3.34e-85 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 266.31 E-value: 3.34e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 15 KTLTLAALGGALEFYDFIIFVFFAAVV-GDLFFPADMPEwLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLS 93
Cdd:cd17369 2 RVALASLVGTAIEWYDFFIYGTAAALVfNKLFFPAVDPA-AGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 94 ILLMALPTLAMGLLPTYASIGIAAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVV 173
Cdd:cd17369 81 LLLMGIATFLIGLLPTYAQIGILAPILLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLATGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 174 ATVINTTLSPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKAlAEELPLKSVVLNHKREVAVSMLLTWL 253
Cdd:cd17369 161 FLLLSALLSDEAFLSWGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQ-VVRAPLVEVLRRHWRALLLAIGLRLA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 254 LSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAGCSWLFYQTVGVRP 333
Cdd:cd17369 240 ENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGS 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727167453 334 EMLFACYALVGFSVG---VVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTPIFVTLIMKLT 396
Cdd:cd17369 320 TWLIVLAAVVVLGVLhgmMYGPQAAFLAELFPTRVRYTGASLGYQLGAILGGGFAPLIATALVAAT 385
|
|
| 2A0106 |
TIGR00883 |
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the ... |
23-403 |
5.06e-81 |
|
metabolite-proton symporter; This model represents the metabolite:H+ symport subfamily of the major facilitator superfamily (pfam00083), including citrate-H+ symporters, dicarboxylate:H+ symporters, the proline/glycine-betaine transporter ProP, etc. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273320 [Multi-domain] Cd Length: 394 Bit Score: 255.28 E-value: 5.06e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 23 GGALEFYDFIIFVFFAAVVGDLFFPADMPEWLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTL 102
Cdd:TIGR00883 1 GNAVEWFDFYLYGFAAVLVFHTFFPPSGDPLVALLATFATFAAGFLARPLGAIVFGHFGDRIGRKKTLVITLLMMGIGTL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 103 AMGLLPTYASIGIAAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTTLS 182
Cdd:TIGR00883 81 LIGLLPSYATIGIWAPILLLLARLIQGFSLGGEWGGAALYLAEYAPPGKRGFYGSFQQVGAPVGLLLAALTVLLLSYLLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 183 PQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAeELPLKSVVLNHKREVAVSMLLTWLLSAGIVVVI 262
Cdd:TIGR00883 161 DDALLEWGWRIPFLVSAVLVLIGLYLRRNLEETPVFEKAQEKHKKK-RGPIAETLTKHRKPFLLGLGLVIATTTTFYLIT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 263 LMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAGCSWLFYQTVGVRPEMLFACYAL 342
Cdd:TIGR00883 240 TYLPTYLTQTLGLSANSALLVLMLSLILFFITIPLSGALSDRIGRRPVLIIFTVLAALLAVPLLMALLDSGSFTLFFFLV 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727167453 343 VGFSV---GVVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTPIFVTLIMKLT--PLAPAYY 403
Cdd:TIGR00883 320 LGMALiggMYTGPMGSFLPELFPTEVRYTGASLAYNLAGAIFGGFAPYIAAALVAMTgdWYAIGYY 385
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
20-404 |
1.40e-73 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 236.12 E-value: 1.40e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 20 AALGGALEFYDFIIFVFFAAVVGDLFFPADmPEWLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMAL 99
Cdd:cd17368 4 ATSGNALEFFDFGVYGFFAVYIGRLFFPSG-SEFASLLLTFATFGVGFFMRPIGAIVLGAYADRIGRKPAMTLTLAIMAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 100 PTLAMGLLPTYASIGIAAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINT 179
Cdd:cd17368 83 GTLLIALAPTYATIGIAAPLLVLLARLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVGYLLSL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 180 TLSPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAEelpLKSVVLNHKREVAVSMLLTWLLSAGIV 259
Cdd:cd17368 163 TLTAEALAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARPTRRE---LFALLANNRRIILLGMLLVAGSTVTFY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 260 VVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAGCSWLFYQTVGVRPE---ML 336
Cdd:cd17368 240 FTTVYTPTYAKTVLGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSfgrLL 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 337 FACYALVGFSVGVVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTPIFVTLIMKLT--PLAPAYYV 404
Cdd:cd17368 320 LVLLVLSFFFGMYGGAMVVALVELFPVRVRSTGFSLVYALAVAIFGGFAQFIVTWLIELTgsPLAPAWYL 389
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
20-403 |
2.90e-69 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 225.25 E-value: 2.90e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 20 AALGGALEFYDFIIFVFFAAVVGDLFFPADMPEwLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMAL 99
Cdd:cd17367 4 GSVGNLVEWYDWYVYAAFALYFAPQFFPSGDPT-VALLSTAAVFAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 100 PTLAMGLLPTYASIGIAAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINT 179
Cdd:cd17367 83 GSLVIAVTPTYATIGIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLQH 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 180 TLSPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEmQARKALAEELPLKSvVLNHKREVAVSMLLTWLLSAGIV 259
Cdd:cd17367 163 TLGEDQMAAWGWRIPFLLGGVLAVVVLWLRRGLEETESFEA-IAESNEASAGTLRE-LRRHPRELLLVVGLTAGGTLAFY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 260 VVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAGCSWLFYQTVGVRPEMLFA- 338
Cdd:cd17367 241 TWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTAf 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727167453 339 CYALVGFSVGVVGAVPYVMVRA--FPAEVRFTGISFSYNVSYAIFGGLTPiFVTLIMKLTPLAPAYY 403
Cdd:cd17367 321 ALVLVGLVFLSGYTSINAVVKAelFPTHVRALGVGLPYALAVAIFGGTAP-YVALWLKSIGHEWVFF 386
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
20-419 |
3.58e-64 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 211.06 E-value: 3.58e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 20 AALGGALEFYDFIIFVFFAAVVGDLFFPADMPEWlRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMAL 99
Cdd:cd17366 4 AALGNAMEWFDFGVYGYLAVTIGKVFFPGGDPTA-QLLATFATFAVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 100 PTLAMGLLPTYASIGIAAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINT 179
Cdd:cd17366 83 STFCIGLLPTYATIGVWAPILLLLARMVQGFSTGGEYGGAATFVAEYAPDRKRGFLGSWLEFGTLAGFILGAGLVTLLTL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 180 TLSPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLqetpifiemqarkalaeelpLKSVVLNHKREVAVSMLLTWLlsagiv 259
Cdd:cd17366 163 LLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRPL--------------------LICIGLVLVFNVTNYMLLSYM------ 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 260 vvilmtPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGS---VLLAGCSWLFYQTVGVrpEML 336
Cdd:cd17366 217 ------PSYLEETLGYSETHGLLVIIIIMVTMLVLQPFLGRLSDRVGRKPVYAAGLaglLVLAVPAFLLMNSGSI--AAI 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 337 FACYALVGFSVGV-VGAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTPIFVTLIMKLT--PLAPAYYVLALSLIGLL 413
Cdd:cd17366 289 FIGLLVLGLLLSCyTATMASTLPALFPTHVRYSALAIAFNISVSLFGGTTPLVASWLVSATgnPLMPAYYLMVAAVVGLV 368
|
....*.
gi 727167453 414 LGVYLH 419
Cdd:cd17366 369 AVLFLT 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-404 |
6.96e-64 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 209.38 E-value: 6.96e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 17 LTLAALGGALEFYDFIIFVFFAAVVGDLFfpadmPEWLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILL 96
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEF-----SLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 97 MALPTLAMGLLPTYASIGIaaplllllMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATV 176
Cdd:cd17316 76 FGLATLLIGLLPTPILLLV--------LRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 177 INTTLSPQSiaggGWRIPFLLGGMFGLVAMYLRRWlqetpifiemqarkalaeelplksvvlnhkreVAVSMLLTWLLSA 256
Cdd:cd17316 148 LIPLLSGDW----GWRILFLIGALPALLALLLRRR--------------------------------TLLLILLWFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 257 GIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAGCSWLFYQTVGVRPEML 336
Cdd:cd17316 192 GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLL 271
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 337 FACYALV-GFSVGVVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTPIFVTLIMK-LTPLAPAYYV 404
Cdd:cd17316 272 LLLLFILsFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAStGGTGVPALIL 341
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
15-423 |
1.40e-55 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 191.46 E-value: 1.40e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 15 KTLTLAALGGALEFYDFIIFVFFAAVVGDLFFPADMPEwLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSI 94
Cdd:PRK10642 16 KAITAASLGNAMEWFDFGVYGFVAYALGKVFFPGADPS-VQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 95 LLMALPTLAMGLLPTYASIGIAAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVA 174
Cdd:PRK10642 95 VIMSISTFCIGLIPSYATIGIWAPILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLDFGSIAGFVLGAGVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 175 TVINTTLSPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIF------IEMQARKALAE--ELPLKSVVLNHKREVAV 246
Cdd:PRK10642 175 VLISTIVGEANFLDWGWRIPFFIALPLGIIGLYLRHALEETPAFqqhvdkLEQGDREGLQDgpKVSFKEIATKHWRSLLT 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 247 SMLLtwLLSAGIVVVILMT--PTYLQKQFGIAPAL-TLQANSIATIMLIAGCIVaGLSADRFGASKTLVVGSV---LLAG 320
Cdd:PRK10642 255 CIGL--VIATNVTYYMLLTymPSYLSHNLHYSEDHgVLIIIAIMIGMLFVQPVM-GLLSDRFGRRPFVILGSValfVLAI 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 321 CSWLFYQT--VGVRPEMLFACYALVGFSVGVVGAVPYVMvraFPAEVRFTGISFSYNVSYAIfGGLTPIFVTLIMKLTP- 397
Cdd:PRK10642 332 PAFILINSnvIGLIFAGLLMLAVILNCFTGVMASTLPAM---FPTHIRYSALAAAFNISVLV-AGLTPTLAAWLVESTQn 407
|
410 420
....*....|....*....|....*..
gi 727167453 398 -LAPAYYVLALSLIGLLLGVYLHRDLN 423
Cdd:PRK10642 408 lMMPAYYLMVVAVIGLITGVTMKETAN 434
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
23-404 |
2.93e-47 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 167.81 E-value: 2.93e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 23 GGALEFYDFIIFVFFAAVVGDLFFPADmPEWLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTL 102
Cdd:PRK15075 23 GNFLEMFDFFLFGFYATAIAKTFFPAG-NEFASLMLTFAVFGAGFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGTL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 103 AMGLLPTYASIGIAAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTTLS 182
Cdd:PRK15075 102 LIAFVPGYATIGLAAPLLVLLGRLLQGFSAGVELGGVSVYLAEIATPGRKGFYTSWQSASQQVAVVFAALLGYLLNQWLS 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 183 PQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAEELplkSVVLNHKREVAVSMLLTWLLSAGIVVVI 262
Cdd:PRK15075 182 PAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEEFLARKHRPSMREIF---RSLAANWRIVLAGMLMVAMTTVSFYLIT 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 263 LMTPTYLQKqfgiapALTLqanSIATIMLIAGCI---------VAGLSADRFGASKTLVVGSVLLA-----GCSWLFYQ- 327
Cdd:PRK15075 259 VYTPTFGKT------VLHL---SAADSLLVTLCVgvsnfiwlpIGGALSDRIGRRPVLIAFTVLAIltaypALSWLVAAp 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 328 ------TVGVRPEMLFACYalvgfSVGVVGAVPYVMvrafPAEVRFTGISFSYNVSYAIFGGLTPIFVTLIMKLT--PLA 399
Cdd:PRK15075 330 sfarmlAVELWLSFLYGSY-----NGAMVVALTEVM----PAEVRTAGFSLAYSLATAIFGGFTPAISTWLIHVTgdKAA 400
|
....*
gi 727167453 400 PAYYV 404
Cdd:PRK15075 401 PGYWL 405
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
23-386 |
3.04e-41 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 151.81 E-value: 3.04e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 23 GGALEFYDFIIFVFFAAVVGDL-FFPADMPEWLRLVqTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPT 101
Cdd:PRK09952 30 GAVVDWYDFLLYGITAALVFNReFFPQVSPAMGTLA-AFATFGVGFLFRPLGGVVFGHFGDRLGRKRMLMLTVWMMGIAT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 102 LAMGLLPTYASIGIAAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTTL 181
Cdd:PRK09952 109 ALIGLLPSFSTIGWWAPVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMT 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 182 SPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAE-ELPLKSVVLNHKRE--VAVSMLLTWLLSAGI 258
Cdd:PRK09952 189 TDEQFLSWGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAAKkRIPVIEALLRHPGAflKIIALRLCELLTMYI 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 259 VVVILMtpTYLQKQFGIAPALTLQ------ANSIATIMLIAgcivagLSADRFGASKTLVVGSVLLAGCSWLFYQTVGVR 332
Cdd:PRK09952 269 VTAFAL--NYSTQNLGLPRELFLNigllvgGLSCLTIPCFA------WLADRFGRRRVYITGALIGTLSAFPFFMALEAQ 340
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 727167453 333 PEMLFACYALVGFSVG---VVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTP 386
Cdd:PRK09952 341 SIFWIVFFSIMLANIAhdmVVCVQQPMFTEMFGASYRYSGAGVGYQVASVVGGGFTP 397
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
20-420 |
1.21e-38 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 144.57 E-value: 1.21e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 20 AALGGALEFYDFIIFVFFAAVVGDLFFPADMPEwLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMAL 99
Cdd:PRK10406 27 ASSGNLVEWFDFYVYSFCSLYFAHIFFPSGNTT-TQLLQTAGVFAAGFLMRPIGGWLFGRIADKHGRKKSMLISVCMMCF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 100 PTLAMGLLPTYASIGIAAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINT 179
Cdd:PRK10406 106 GSLVIACLPGYETIGTWAPALLLLARLFQGLSVGGEYGTSATYMSEVAVEGRKGFYASFQYVTLIGGQLLALLVVVVLQQ 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 180 TLSPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETpifiEMQARKALAEELPLKSVVLNHKrevAVSMLLTWllSAGIV 259
Cdd:PRK10406 186 TLEDAELREWGWRIPFALGAVLAVVALWLRRQLDET----SQQETRALKEAGSLKGLWRNRR---AFIMVLGF--TAAGS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 260 VVILMTPTYLQKQfgIAPALTLQANSIATIMLIAGCI------VAGLSADRFGASKTLVVGSVLLAGCS---WLFYQTVg 330
Cdd:PRK10406 257 LCFYTFTTYMQKY--LVNTAGMHANVASGIMTAALFVfmliqpLIGALSDKIGRRTSMLCFGSLAALFTvpiLSALQNV- 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 331 VRPEMLFACYAL----VGFSVGVVGAVPYVMvraFPAEVRFTGISFSYNVSYAIFGGlTPIFVTLIMKLTPLAPAY--YV 404
Cdd:PRK10406 334 SSPYAAFGLVMCalliVSFYTSISGILKAEM---FPAQVRALGVGLSYAVANALFGG-SAEYVALSLKSIGMETAFfwYV 409
|
410
....*....|....*.
gi 727167453 405 LALSLIGLLLGVYLHR 420
Cdd:PRK10406 410 TLMAVVAFLVSLMLHR 425
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
19-401 |
4.96e-30 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 120.10 E-value: 4.96e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 19 LAALGGALEFYDFIIFVFFAAVVGDLFfPADMPEWLRLVQTFGIFAAgylarpLGGIVMAHFGDLVGRKKMFTLSILLMA 98
Cdd:cd17371 3 AAFLGWALDGFDLLLLGLVLPALIAEF-GLDEAEAGLLGTVTLAGGA------IGGILGGILADRFGRVRVLVITILLFA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 99 LPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLgsvvATVIN 178
Cdd:cd17371 76 VFTLLCGFAQNYWQLLIL--------RALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLL----ATLLA 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 179 TTLSPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAEELPLKSVVLNhkREVAVSMLLTWLLSAGI 258
Cdd:cd17371 144 ALLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSLRELFS--PPLLRTTLLASLLATGA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 259 VV----VILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAGCSWLFYQTVGVRPE 334
Cdd:cd17371 222 LGgyygITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTL 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727167453 335 MLFACYALVGFSVGVVGAVPYVMVRAFPAEVRFTGISFSYNVSYAIfGGLTPIFVTLIMKLTPLAPA 401
Cdd:cd17371 302 ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRII-GALFPFLVGFLATSGSLGTA 367
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-396 |
4.19e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 117.29 E-value: 4.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 14 YKTLTLAALGGALEFYDFIIFVFFAAVVGDLFfpadmpeWLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLS 93
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEF-------GLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 94 ILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVV 173
Cdd:COG2223 77 LLLLGIGLLLLALAVSYWLLLLL--------GLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 174 ATVInttlspqsIAGGGWRIPFLL-GGMFGLVAMYLRRWLQETPIFIEMQARKALAEELplksVVLNHKREVAVSMLLTw 252
Cdd:COG2223 149 APLL--------IAAFGWRNAFLIlGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQL----EALRDPRFWLLSLLYF- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 253 LLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAGCSWLFYQTVGVR 332
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727167453 333 PEMLFACYALVGFSVGVVGAVPYVMVRAFPAEVRFTGISFSYnVSYAIFGGLTPIFVTLIMKLT 396
Cdd:COG2223 296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVG-AAGGLGGFLGPLLFGALLDAT 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
6-404 |
1.73e-25 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 106.49 E-value: 1.73e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 6 NRRLNRQDYKTLTLAALGGALEFYDFIIFVFFAAVVGDLFFpadmpewLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVG 85
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLG-------LSAAQLGLLASAFFLGYALGQIPAGLLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 86 RKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTV 165
Cdd:COG2271 74 RRRVLAIGLLLWGLATLLFGFATSFWQLLLL--------RFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 166 GILLGSVVATVInttlspqsIAGGGWRIPFLLGGMFGLVAMYLRRWLqetpifiemqarkalaeelplksvvlnhkreva 245
Cdd:COG2271 146 GGALAPPLLGWL--------LAAFGWRAAFLILGLPGLLLALLRFWL--------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 246 vsMLLTWLLSAGIVVVILM-TPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGAS-KTLVVGSVLLAGCSW 323
Cdd:COG2271 185 --LALAYFLVYFALYGFLTwLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALAL 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 324 LFYQTVGVrPEMLFACYALVGFSVGVVGAVPYVMVR-AFPAEVRFTGISFsYNVSYAIFGGLTPIFVTLIMKLTPLAPAY 402
Cdd:COG2271 263 LLLALLPS-PALAIALLFLAGFGLGGAFGLLWALAAeLFPKKARGTASGL-VNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
..
gi 727167453 403 YV 404
Cdd:COG2271 341 LL 342
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-379 |
2.45e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 105.83 E-value: 2.45e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 11 RQDYKTLTLAALGGALEFYD-FIIFVFFAAVVGDLFFPADMPEWlrlvqtfgIFAAGYLARPLGGIVMAHFGDLVGRKKM 89
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGiGIVLPALPLIAADLGASPAQAGL--------VVTAYLLGAALGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 90 FTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILL 169
Cdd:COG2814 78 LLLGLLLFALGSLLCALAPSLWLLLAA--------RFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 170 GSVVATVINTTLspqsiaggGWRIPFLLGGMFGLVAMYL-RRWLQETPIFIEMQARKALAEELplksvvlnHKREVAVSM 248
Cdd:COG2814 150 GPLLGGLLADLF--------GWRWVFLVNAVLALLALLLlLRLLPESRPAARARLRGSLRELL--------RRPRLLLLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 249 LLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAGCSWLFYQT 328
Cdd:COG2814 214 LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 727167453 329 VGvrPEMLFACYALVGFSVGVVGAVPYVMV-RAFPAEVRFTGISFSYNVSYA 379
Cdd:COG2814 294 GS--LWLLLLALFLLGFGFGLLFPLLQALVaELAPPEARGRASGLYNSAFFL 343
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
6-320 |
1.07e-24 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 102.97 E-value: 1.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 6 NRRLNRQDYKTLTLAALGGALEFYDFIIFVFFAAVVGDLF-FPADMPEWlrlvqtfgIFAAGYLARPLGGIVMAHFGDLV 84
Cdd:COG0477 5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLgASSAQLGW--------IVSAYLLGRAIGLLLFGRLGDRY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 85 GRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLT 164
Cdd:COG0477 77 GRKRVLLIGLLLFGLASLLCGLAPSPELLIAA--------RALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 165 VGILLGSVVATVINTTLspqsiaggGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAEELPLKSVVLnhkREV 244
Cdd:COG0477 149 LGLALGPLLGGLLVAAL--------GWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALA---LLA 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727167453 245 AVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAG 320
Cdd:COG0477 218 LLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
7-401 |
1.55e-24 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 105.55 E-value: 1.55e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 7 RRLNRQDYKTLTLAALGGALEFYDFIIFVFFAAVVGDLFfpadmpeWLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGR 86
Cdd:PRK03893 12 RHLNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEF-------GLTTVQAASLISAAFISRWFGGLLLGAMGDRYGR 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 87 KKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVG 166
Cdd:PRK03893 85 RLAMVISIVLFSVGTLACGFAPGYWTLFIA--------RLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 167 ILLGSVVATVInttlspqsIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPifiEMQARKALAEELPLKSVVLNHKREVAV 246
Cdd:PRK03893 157 AVVAAQVYSLV--------VPVWGWRALFFIGILPIIFALWLRKNLPEAE---DWKEKHAGKAPVRTMVDILYRGEHRII 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 247 SMLLT-------------------------------------------WLLSAGIVVVIL-----------MTPTYLQKQ 272
Cdd:PRK03893 226 NILLTlaaaaalwfcfagnlqnaaivavlgllcaaifisfmvqssgkrWPTGVMLMVVVLfaflyswpiqaLLPTYLKTD 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 273 FGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGsvLLAGCSW---LFYQTVGVRPEMLFACYALVGFSVGV 349
Cdd:PRK03893 306 LGYDPHTVANVLFFSGFGAAVGCCVGGFLGDWLGTRKAYVCS--LLISQLLiipVFAIGGANVWVLGLLLFFQQMLGQGI 383
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|..
gi 727167453 350 VGAVPYVMVRAFPAEVRFTGISFSYNVSyAIFGGLTPIFVTLIMKLTPLAPA 401
Cdd:PRK03893 384 SGLLPKLIGGYFDTEQRAAGLGFTYNVG-ALGGALAPILGALIAQRLDLGTA 434
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
5-376 |
1.28e-22 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 98.97 E-value: 1.28e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 5 NNRRLNRQDYKTLTLAALGGALEFYDFIIFVFFAavvgdlffPADMPEW-LRLVQTFGIFAAGYLARPLGGIVMAHFGDL 83
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAA--------PAISAEWgLDPVQLGFLFSAGLIGMAFGALFFGPLADR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 84 VGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGL 163
Cdd:TIGR00895 79 IGRRRVLLWSILLFSVFTLLCALATNVTQLLIL--------RFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGY 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 164 TVGILLGsvvatvinTTLSPQSIAGGGWRIPFLLGGMFGLV-AMYLRRWLQETPIF---------------IEMQARKAL 227
Cdd:TIGR00895 151 PIGAAVG--------GFLAGWLIPVFGWRSLFYVGGIAPLLlLLLLMRFLPESIDFlvskrpetvrrivnaIAPQMQAEA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 228 AEELPLKSVVLNHKREV---------AVSMLLTWLL-SAGIVVVILMTP--TYLQKQFGIAPALTLQANSIATIMLIAGC 295
Cdd:TIGR00895 223 QSALPEQKSTQGTKRSVfkalfqgktARITVLLWLLyFMLLVGVYFLTNwlPKLMVELGFSLSLAATGGALFNFGGVIGS 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 296 IVAGLSADRFGaSKTLVVGSVLLAGCSWLFYQTVGVRPEMLFACYALVGFSVGVVGAVPYVMVRAFPAEVRFTGISFSYN 375
Cdd:TIGR00895 303 IIFGWLADRLG-PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIG 381
|
.
gi 727167453 376 V 376
Cdd:TIGR00895 382 I 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
62-404 |
1.32e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 95.72 E-value: 1.32e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 62 IFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWV 141
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLA--------RFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 142 FVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVInttlspqsIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIfIEM 221
Cdd:cd17325 108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL--------ADALGYRAPFLVCAALALLALVLALLLLPEPR-PPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 222 QARKALAEELPLKSVVLNHKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLS 301
Cdd:cd17325 179 NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 302 ADRFGASKTLVVGSVLLAGCSWLFYQTVGVrpEMLFACYALVGFSVGVVGAVPYVMV-RAFPAEVRFTGISFsYNVSYAI 380
Cdd:cd17325 259 SDRIGRKPLILIGLLLSAVALLLLPLATSF--WLLLLLLALLGLGLGLVFPATLALLaDIVPPEGRGTAMGL-FNTAFSL 335
|
330 340
....*....|....*....|....
gi 727167453 381 FGGLTPIFVTLIMKLTPLAPAYYV 404
Cdd:cd17325 336 GMVLGPLLGGFLYDAFGFATPFLA 359
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
18-404 |
4.13e-18 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 86.17 E-value: 4.13e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 18 TLAALGGALEFYDFIIFVFFAAVVGDLFF----PADMPEWLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLS 93
Cdd:pfam00083 3 LVAALGGFLFGYDTGVIGAFLTLIDFFKNfglsKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 94 ILLMALPTLAMGllptyASIGIAAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVV 173
Cdd:pfam00083 83 NVLFVIGAVLQG-----AAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 174 ATVINTTLspqsiAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAEE----------------------- 230
Cdd:pfam00083 158 GLGLNKTS-----NSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREvlaklrgvpdvdreldeikdsle 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 231 ----------LPLKSVVLNHKREVAVSMLLTWLLSAGIVVVILMtPTYLQKQFGIAPalTLQANSIATIMLIAGCIVAGL 300
Cdd:pfam00083 233 agqeaekaswKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYY-STTIFENLGLSD--SFLVTIIVGVVNFVFTFIAIF 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 301 SADRFGASKTLVVGSVLLAGCSWLFYQTVGVRPE--------MLFACYALVGFSVGVVGAVPYVMV-RAFPAEVRFTGIS 371
Cdd:pfam00083 310 LVDRFGRRPLLLLGAAGMAICFVILGIVALLGVSksdwagivAIVFIALFIAFFAMGWGPVPWVIVsELFPLSVRSKAMA 389
|
410 420 430
....*....|....*....|....*....|...
gi 727167453 372 FSYNVSYaIFGGLTPIFVTLIMKLTPLAPAYYV 404
Cdd:pfam00083 390 LATAANW-LANFLIGFLFPIITDAIGLGYTFFI 421
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
62-386 |
5.05e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 79.00 E-value: 5.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 62 IFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWV 141
Cdd:pfam07690 37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVL--------RVLQGLGAGALFPAALA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 142 FVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVInttlspqsIAGGGWRIPFLLGGMFGLVAMYLrRWLQETPIFIEM 221
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLL--------ASLFGWRAAFLILAILSLLAAVL-LLLPRPPPESKR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 222 QARKALAEELPLKSVVLNHKREVAVSMLLTWLLSAGIVVVILMTPTYlQKQFGIAPALTLQANSIATIMLIAGCIVAGLS 301
Cdd:pfam07690 180 PKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 302 ADRFGASKTLVVGSVLLAGCSW-LFYQTVGVRPEMLFACYALVGFSVGVV-GAVPYVMVRAFPAEVRFTGISFsYNVSYA 379
Cdd:pfam07690 259 SDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLLLGFGFGLVfPALNALVSDLAPKEERGTASGL-YNTAGS 337
|
....*..
gi 727167453 380 IFGGLTP 386
Cdd:pfam07690 338 LGGALGP 344
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
46-384 |
4.38e-15 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 76.08 E-value: 4.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 46 FPADMPEWLRLVQTFG-IFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllm 124
Cdd:cd17365 22 APALAQDWGLSPAQLGpVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL-------- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 125 RVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVInttlspqsIAGGGWRIPFLLGGMFGLV 204
Cdd:cd17365 94 RFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAAL--------IPAFGWRSVFLLGGVPPLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 205 AMYLrrwlqetpifiemqarkalaeelplksvvlnhkrevAVSMLLTWLLSAGIVVVILMTPTYLQKQFgIAPALTLQAN 284
Cdd:cd17365 166 LLPL------------------------------------LRGTLLLWVTFFMGLLLVYLLNSWLPKLM-VEAGYSLSQA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 285 SIATIML----IAGCIVAGLSADRFGASKTLVVGSVLLAGCSWLFyQTVGVRPEMLFACYALVGFSV-GVVGAVPYVMVR 359
Cdd:cd17365 209 LTITLLLniggVIGSLLLGWLADRFGPKRVLALFFALGAVSLALL-GVSPASLVLLYVLVFLAGACVnGAQVGLYALAAR 287
|
330 340
....*....|....*....|....*..
gi 727167453 360 AFPAEVRFTGISFSYNVSY--AIFGGL 384
Cdd:cd17365 288 FYPTEVRATGVGWALGVGRlgAILGPL 314
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
58-384 |
9.46e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 75.28 E-value: 9.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 58 QTFGIFAAGYLarpLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVP 137
Cdd:cd17324 38 LLVSAYALGYA---LGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA--------RALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 138 GAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTTLspqsiaggGWRIPFLLGGMFGLVAMY-LRRWLQETP 216
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL--------GWRAAFLAIAVLALLAALlLWRLLPSLP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 217 IFIEMQARKALAEELPLKSVVLnhkrevAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCI 296
Cdd:cd17324 179 PKKPGSLGLLSSLLLLLRNPRL------RLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 297 VAGLSADRFGAsKTLVVGSVLLAGCSWLFYQTVgvrPEMLFACYALVGFSVGVVGAVPYVMVRAFPAEVRFTGISFS-YN 375
Cdd:cd17324 253 LAGRLADRGGR-RALLIALLLLAAALLLLTLLG---PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSlYL 328
|
....*....
gi 727167453 376 VSYAIFGGL 384
Cdd:cd17324 329 AAYNLGGAL 337
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
62-392 |
3.84e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 73.61 E-value: 3.84e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 62 IFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWV 141
Cdd:cd06174 36 LFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG--------RFLLGLGSGLIDPAVLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 142 FVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINttlspqSIAGGGWRIPFLL-GGMFGLVAMYLRRWLQETPIFIE 220
Cdd:cd06174 108 LIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA------SSLGFGWRAVFLIaAALALLAAILLLLVVPDPPESAR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 221 MQARKALAEELPLKSVVLNHKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGL 300
Cdd:cd06174 182 AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 301 SADRFGASKTLVVGSVLLAGCSWLFYQTVGVRPEMlFACYALVGFSVGVVGAVPYVMV-RAFPAEVRFTGISFsYNVSYA 379
Cdd:cd06174 262 LSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL-LLLLLLLGFGLGGLLPLSFALIaELFPPEIRGTAFGL-LNTFGF 339
|
330
....*....|...
gi 727167453 380 IFGGLTPIFVTLI 392
Cdd:cd06174 340 LGGAIGPLLAGFL 352
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
76-393 |
1.10e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 72.23 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 76 VMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAiGGEVPGAWVFVAEHVPRRRIGFA 155
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG--------RALQGIG-GAVFPLAFALVREEFPPERVPVA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 156 CGTLTAGLTVGILLGSVVATVINTTLspqsiaggGWRIPFLLGGMFGLVAMYLrrwlqetpifiemqarkalaeeLPLKS 235
Cdd:cd17504 121 QGILSATFGIGAGIGLPLGGWIVQHL--------GWRWIFWTAAPVAVLLAAL----------------------VPLID 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 236 VVLNHKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALT-LQANSI----ATIMLIAGcIVAGLSADRFGASKT 310
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGiTEAGLLllpgALVMLIAG-PLAGRLIARVGPRRV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 311 LVVGSVLLAGcSWLFYQTVGVRPEMLFACYALVGFSVG-VVGAVPYVMVRAFPAEvrFTGISFSYN-VSYAIFGGLTPIF 388
Cdd:cd17504 250 LLIGLVISAV-GLLLLALLHSSLWALVVALLLIGIGLGlAFASLPNIVVESVPPD--RTGIATGMNtVLRTIGSAIGPAI 326
|
....*
gi 727167453 389 VTLIM 393
Cdd:cd17504 327 AGAIL 331
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
75-385 |
1.51e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 71.44 E-value: 1.51e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 75 IVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIgIAAplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGF 154
Cdd:cd17321 49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFL-IAA-------RALQGIGAAAIMPASLALIAATFPGERRGR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 155 ACGTLTAGLTVGILLGSVVATVINTTLspqsiaggGWRIPFLLGGMFGLVAMYLrrwlqetpifiemqarkalaeelplk 234
Cdd:cd17321 121 ALGLWGAVVGIGAALGPLLGGLLLELF--------GWRWIFLINVPIGLVALLL-------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 235 svvlnhKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVG 314
Cdd:cd17321 167 ------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 315 SVLLA-GCSWLFYQTVGVRPEMLFACYALVGFSVG-VVGAVPYVMVRAFPAE-----------VRFTGISFSYNVSYAIF 381
Cdd:cd17321 241 LLLTAvGLLLLALLGADSSVWLLLPGLVLLGLGLGlFATPLTNAALSSVPKEkagaasgilntARQLGGALGVALLGALL 320
|
....
gi 727167453 382 GGLT 385
Cdd:cd17321 321 TAGL 324
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
60-396 |
3.60e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 70.29 E-value: 3.60e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 60 FGIFAAGYLarpLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGA 139
Cdd:cd17319 44 ASAFFLGYA---LFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVL--------RFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 140 WVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVInttlspqsIAGGGWRIPFLLGGMFGLVA-----MYLRRWLQE 214
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL--------LLLFGWRWAFIIEGLLGLLLavlwwFYLRQVWGL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 215 TPIFIEMQArkalaeelplksvvlnhkrevAVSMLLTWLlsagivvvilmtPTYLQKQFGIAPALTLQANSIATIMLIAG 294
Cdd:cd17319 185 ALGYFGINY---------------------ALYGLLTWL------------PTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 295 CIVAGLSADRF--GASKTLVVGSVLLAGCSWLFYQTVGVrPEMLFACYALVGFSVGVVGAVPYVMV-RAFPAEVRFTGIS 371
Cdd:cd17319 232 MILGGRLSDRLlrGARRLVIIIGLLLAAVGLLLAYLTTS-PVVAVILLSLAGFGIGAASPVFWSLPaDLLPGEAAATAGG 310
|
330 340
....*....|....*....|....*
gi 727167453 372 FsYNVSYAIFGGLTPIFVTLIMKLT 396
Cdd:cd17319 311 L-INSGGNLGGFVAPLLIGYLVDAT 334
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
7-392 |
6.12e-13 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 69.96 E-value: 6.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 7 RRLNRQDYKTLTLAALGGALEFYDFIIFVFFAAVVGDLFFPADMpewlrlvQTFGIFAAGYLARPLGGIVMAHFGDLVGR 86
Cdd:PRK12307 10 SEITRPQKNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDM-------EGAFLATAAFIGRPFGGALFGLLADKFGR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 87 KKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVG 166
Cdd:PRK12307 83 KPLMMWSIVAYSVGTGLSGLASGVIMLTLS--------RFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 167 illgsvvaTVINTTLSPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAEELPLKSVVLNHKREVAV 246
Cdd:PRK12307 155 --------NIIAAYFMPSFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGKHSQSAWSVFSLSMKGLFN 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 247 SMLLTWLLSAGIVVVIL---------MTPTYLQKQfGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVL 317
Cdd:PRK12307 227 RAQFPLTLCVFIVLFSIfganwpifgLLPTYLAGE-GFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLM 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 318 lagcSWLFYQTVGVRPE----MLFAC-YALVGFSVGVVGAVPYVMVRAFPAEVRFTGISFSYNVSyAIFGGLTPIFVTLI 392
Cdd:PRK12307 306 ----SFLFIFPLFRIPQdnylLLGAClFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLA-ATSGTFNSMAATWL 380
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
55-370 |
4.36e-12 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 67.29 E-value: 4.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 55 RLVQTFG--------IFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRV 126
Cdd:PRK11551 40 RMAQEFGldvaqmgwAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVA--------RL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 127 LQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVinttlspqSIAGGGWRIPFLLGGMFGLVAM 206
Cdd:PRK11551 112 LTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVL--------AAGDAAWRHIFYVGGVGPLLLV 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 207 -YLRRWLQETPIFIemQARKALAEELPLKSVVLNHKRevAVSMLLTWL--LSAGIVVVILMT--PTYLQKQfGIAPAltl 281
Cdd:PRK11551 184 pLLMRWLPESRAFA--QAAGAGKQRAPVLRALFGEGR--ATATLLLWIsyFFTLIVLYFLLNwlPSLLVGQ-GLSRS--- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 282 QANsIATIML----IAGCIVAGLSADRFGASKTlvvgSVLLAGCSWLFYQTVGVRPEmlFACYALVGFSVG--VVGA--V 353
Cdd:PRK11551 256 QAG-LVQIAFniggALGSLLIGALMDRLRPRRV----VLLIYAGILASLAALAAAPS--FAGMLLAGFAAGlfVVGGqsV 328
|
330
....*....|....*...
gi 727167453 354 PYVMVRAF-PAEVRFTGI 370
Cdd:PRK11551 329 LYALAPLFyPTQVRGTGV 346
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
59-377 |
1.29e-10 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 62.67 E-value: 1.29e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 59 TFGI-FAAGYLARPLGGIvmahFGDLVGRKKMFTLSILLMALPTLAMGLLPTYasigiaapLLLLLMRVLQGAaIGGEVP 137
Cdd:cd17391 41 AFSStFLVSAIFSPIWGR----LADRYGRKPMLLRASLGMAIVIGLMAFVTNV--------WQLLILRLLQGV-FSGYVP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 138 GAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTTLspqsiaggGWRIPFLLGGMFGLVAMYLrrwlqeTPI 217
Cdd:cd17391 108 NATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLF--------GIRNVFFITGGLLFLAFLL------TLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 218 FI-EMQARKALAEELPLKSVvlnhkrevavsmlLTWLLSAGIVVVILMTPTYLQ-KQFGIAPALTLQANSIAT----IML 291
Cdd:cd17391 174 FVkEDFKPVEKKKMVSTKEV-------------WNSVPNPSLLISLFVTTFIIQlANQSIEPILTLYIRQLMGdasnLAF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 292 IAGCIVA--GLSA-----------DRFGASKTLVVGsvLLAGCSWLFYQTVGVRPEMLFACYALVGFSVGV-VGAVPYVM 357
Cdd:cd17391 241 ISGLVFSatGVSSllsaprlgklgDRIGHHRILLGA--LLASALLYIPQAFVQTPWQLGILRFLLGLATGGlLPAINSLL 318
|
330 340
....*....|....*....|
gi 727167453 358 VRAFPAEVrfTGISFSYNVS 377
Cdd:cd17391 319 AKITPKEV--AGRIFGYNQS 336
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
80-350 |
1.70e-10 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 62.21 E-value: 1.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 80 FGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTL 159
Cdd:cd17503 54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIF--------RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLV 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 160 TAGLTVGILLGSVVATVINTTLSpqsiagggWRIPFLLGGMFGLVAMYLrrwlqetpifiemqarkalaeeLPLKSVVLN 239
Cdd:cd17503 126 GLVILLAPAIGPTLGGWLTDNLS--------WRWIFYINLPIGILALLL----------------------APLLDLRLF 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 240 HKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPaltlqanSIATIMLIAGCIVAGLSA-------DRFGASKTLV 312
Cdd:cd17503 176 KDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSA-------FESGLVLAPGGLASAILSplvgrllDKFGPRLLLL 248
|
250 260 270
....*....|....*....|....*....|....*....
gi 727167453 313 VGSVLLA-GCSWLFYQTVGVRPEMLFACYALVGFSVGVV 350
Cdd:cd17503 249 AGLLLLAlGTLLLAFLTPDTSLWLIILPLFIRGLGMGLV 287
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
62-404 |
4.11e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 57.94 E-value: 4.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 62 IFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAAplllllmrVLQGAAIGGEVPGAWV 141
Cdd:COG0738 48 LLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLAL--------FLLGLGLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 142 FVAEHVP---RRRIGFACGTLTAGLTVGILLGSVVATvinttlspqSIAGGGWRIPFLLGGMFGLVAMYLRrWLQETPiF 218
Cdd:COG0738 120 YVAALGPetaASRLNLLHAFFSLGALLGPLLGGLLIL---------LGLSLSWHLPYLILAVLLLLLALLF-LRSKLP-E 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 219 IEMQARKALAEELPLKSVVlnhKREVAVSMLLTWLLSAGI-VVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIV 297
Cdd:COG0738 189 IEEEEEEAAGSAASLKSLL---KNPRLLLGGLAIFLYVGAeGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 298 AGLSADRFGASKTLVVGSVLLAGCSWLFYQTVGvrPEMLFACYALVGFSVGVVgaVPYVMVRAFPAEVRFTGISFSYNVS 377
Cdd:COG0738 266 GGFLLKRFGPVRLLRLSALLAAVGLLLALLAPG--PWLALIGLALVGLGLSLM--FPTIFSLALDGLGKRTAAAVSAVLI 341
|
330 340
....*....|....*....|....*...
gi 727167453 378 YAIFGGLT-PIFVTLIMKLTPLAPAYYV 404
Cdd:COG0738 342 MGIVGGAIgPPLIGFLADAFGLRAAFLV 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
160-396 |
5.98e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.60 E-value: 5.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 160 TAGLTVGILLGSVVATVINTTLSPQSIAGggWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAEelpLKSVVLN 239
Cdd:COG2211 153 FAFAGLGGLLASVLPPPLVAAFGGDAALG--YRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES---LKALLKN 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 240 HK-REVAVSMLLTWLlsaGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLL 318
Cdd:COG2211 228 RPfLLLLLAYLLFFL---ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLA 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 319 AGCSWLFYQTVGVRPEMLFACYALVGFSVGVVGAVPYVMV------RAFPAEVRFTGISFS-YNVSYAIFGGLTPIFVTL 391
Cdd:COG2211 305 ALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdyDEWKTGRRREGLYFGiFTFAIKLGQALAGALAGL 384
|
....*
gi 727167453 392 IMKLT 396
Cdd:COG2211 385 LLALF 389
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
80-404 |
5.08e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 54.53 E-value: 5.08e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 80 FGDLVGRKKMFTLS-ILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPgAWVFVAEHVPRRRIGFACGT 158
Cdd:cd17490 54 LSDRIGKRKLFIIIgLLFTVLASLIMILFPSPWGLLIA--------RFLSGIAAATWVS-FTVLYASYFPPDEAAKAMGL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 159 LTAGLTVGILLGSVVATVINTTLspqsiaggGWRIPFLLGGMFGLVAMYLRRWLQETPifieMQARKALAEELPLKSVVL 238
Cdd:cd17490 125 INLVNNLGQLIAFLIGGLIAEHF--------GMRAPFLLAALAGVLGFILSLFIKEER----REKKPVLTELKELLSVLK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 239 NhKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLqansIATIMLIAGCIVAGLSA----DRFGASKTLVVG 314
Cdd:cd17490 193 D-KKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGL----LSIIYLLPNALASLLSGtlfyKKLGERNTIIIG 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 315 SVLLAGCswLFYQTVGVRPEMLFACYALVGFSVGVVgaVPYVM---VRAFPAEVRFTGISFsYNVSYAIFGGLTPIFVTL 391
Cdd:cd17490 268 FLLLGAY--CFLIPFAPNLTLLYLLQALNGFGTGIL--FPLLMslsIEGVPAEQRSTAMGF-FQAIYALGMFLGPVLVGI 342
|
330
....*....|...
gi 727167453 392 IMKLTPLAPAYYV 404
Cdd:cd17490 343 ISEAFGLQTGFFV 355
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
73-212 |
1.09e-07 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 53.44 E-value: 1.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 73 GGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIaaPLLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRI 152
Cdd:cd17364 55 GQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGV--MGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRR 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727167453 153 GFACGTLTAGLTVGILLGSVVATVINTTLSPQSIAG------GGWRIPFLLGGMFGLVAMYLRRWL 212
Cdd:cd17364 133 GALIAAVFAMQGFGILAGAIVTLILSAIFEHPLPAGtyhhadLVWRIVLGLGAIPALSVLYFRKHL 198
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
7-216 |
1.98e-07 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 53.19 E-value: 1.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 7 RRLNRQDYKTLTLAALGGALEFYDFIIFVFFAAVVGDLFFPADMPewLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGR 86
Cdd:TIGR00887 8 APFGWQHFRAIVIAGVGFFTDSYDLFCISLVTKMLGYVYYHGKGP--LPSSVSAAVNGSASIGTLAGQLFFGWLADKLGR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 87 KKMFTLSILLMALPTLAMGLLPTYASIGIAAplLLLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIG------FAC---G 157
Cdd:TIGR00887 86 KRVYGMELIIMIIATVASGLSPGSSPKSVMA--TLCFWRFWLGVGIGGDYPLSAIITSEFATKKWRGammaavFAMqgfG 163
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727167453 158 TLTAGLTVGILLGS------VVATVINTTLSPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETP 216
Cdd:TIGR00887 164 ILAGAIVALIVLAGfkhsleAAADEASCTGSCVPAVDYMWRILIGFGAVPALLALYFRLTIPETP 228
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
72-324 |
5.84e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.41 E-value: 5.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 72 LGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAAplllllmrVLQGAAIGGEVPGAWVFVAEHVPRRr 151
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGT--------ALIGAGIAVGNVLLPGLIKRWFPDR- 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 152 IGFACGTLTAGLTVGILLGSVVATVInttlspqsIAGGGWRIPFLLGGMFGLVAMYLrrWLqetPIFIEMQARKALAEEL 231
Cdd:COG2807 139 VGLMTGLYTAAMGLGAALAAGLTVPL--------AAALGWRGALAVWALLALLALLL--WL---PLLRRRPAAAAAAPAA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 232 PLKSVVLNHKREVAVSMLLTwLLSAGIVVVILMTPTYLQkQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTL 311
Cdd:COG2807 206 ASLRSLWRSPLAWLLTLFFG-LQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPL 283
|
250
....*....|...
gi 727167453 312 VVGSVLLAGCSWL 324
Cdd:COG2807 284 LLLLGLLGLAGLL 296
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
63-396 |
7.02e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 51.06 E-value: 7.02e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 63 FAAGYLARPLGGIVMahfgDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVF 142
Cdd:cd17489 41 TLAALLARPFAGRLL----DRFGRKRLLLIGLLIFALATLLYLLATSVALLLVL--------RLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 143 VAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTTLSPQSIagggwripFLLGGMFGLVAMYLRRwlqetpiFIEMQ 222
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVL--------FIVAAVLALLALLLVF-------LVKDP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 223 ARKALAEELPLKSVVLNHKREVA-VSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLqanSIATIMLIAGCIVAGLS 301
Cdd:cd17489 174 PPVAAEEAEAGTRAFRRLVEKKVlPPALILFLASIAYGAISTFLPLYAAERGISNAGLFF---TVYAIALLLSRPFSGKL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 302 ADRFGASKTLVVGSVLLAGCSWLFYQTVGvrPEMLFACYALVGFSVG-VVGAVPYVMVRAFPAEVRFTGISfSYNVSYAI 380
Cdd:cd17489 251 SDRKGPKTVIIPGLLLLALGLLLLSFAGS--PWMLLLAAVLYGLGFGlLFPALQALAVDLVPPHRRGAANG-TFFIFFDL 327
|
330
....*....|....*.
gi 727167453 381 FGGLTPIFVTLIMKLT 396
Cdd:cd17489 328 GIGLGGLLLGLVAELF 343
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
80-388 |
1.16e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 50.25 E-value: 1.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 80 FGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTL 159
Cdd:cd17502 53 LSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVG--------RAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYI 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 160 TAGLTVGILLGSVVATVINTTLSpqsiagggWRIPFLLGGMFGLVAMYLrrwlqetpifiemqarkalaeelplksvvln 239
Cdd:cd17502 125 GAVFGIASVAGPLIGGAFTDHLS--------WRWCFYINLPIGGLALAL------------------------------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 240 hKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLA 319
Cdd:cd17502 166 -LRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVIGTILM 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 727167453 320 --GCSWLFYQTVGVRPEMLFACYALVGFSVGVVGAVPYVMVR-AFPAEVRFTGISFSY---NVSYAIFGGLTPIF 388
Cdd:cd17502 245 svGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQnAVPPADVGVATATNTffrSLGGTLGVAITDVF 319
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-358 |
1.21e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.25 E-value: 1.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 56 LVQTFGIFAAgyLARPLGGIvmahFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAAplllllmrVLQGAAIGGE 135
Cdd:cd17478 36 LVSVFSITSS--LLQPLFGY----LADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV--------ALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 136 VPGAWVFVAeHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTTLspqsiAGGGWRIPFLLGGMFGLVAMYLRRWLQET 215
Cdd:cd17478 102 HPEGARLAS-QAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALF-----GGLGLLILLIIPGLAVALLLLRLRPLKKP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 216 PIFIEMQARKALAEELPLKSVVLnhkREVAVSMLLTWLLSAGIVVVilmtPTYLQKQFGIapalTLQANSIATIMLIA-- 293
Cdd:cd17478 176 EAKKAAAKSSARSTLKGVWRALL---LLLIIVFLRSWVLSSLTTFL----PFYLVQRGYS----LVFAGLLLSLFLFAga 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 727167453 294 -GCIVAGLSADRFGASKTLVVGSVLLAGCSWLFYQTVGVrpeMLFACYALVGFSVGVVGAVPYVMV 358
Cdd:cd17478 245 iGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGI---WSYILLVLAGFLLFASFPVTVVLA 307
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
62-385 |
1.88e-06 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 49.92 E-value: 1.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 62 IFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIaaplllllMRVLQGAaIGGEVPGAWV 141
Cdd:PRK09874 59 VFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLI--------LRALLGL-LGGFVPNANA 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 142 FVAEHVPRRRIGFACGTLTAGLTVGILLGsvvatvinttlspqSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEM 221
Cdd:PRK09874 130 LIATQVPRNKSGWALGTLSTGGVSGALLG--------------PLAGGLLADSYGLRPVFFITASVLFLCFLVTLFCIRE 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 222 QArkalaeeLPLKSVVLNHKREVAVSmlltwLLSAGIVVVILMTPTYLQKQFG-IAPALTLQ----ANSIATIMLIAGCI 296
Cdd:PRK09874 196 NF-------QPVSKKEMLHMREVVTS-----LKNPKLVLSLFVTTLIIQVATGsIAPILTLYvrelAGNVSNIAFISGMI 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 297 --VAGLSA-----------DRFGASKTLVVG---SVLLAgCSWLFYQTvgvrPEMLFACYALVGFSVG-VVGAVPYVMVr 359
Cdd:PRK09874 264 asVPGVAAllsaprlgklgDRIGPEKILITAlifSVLLL-IPMSFVQT----PLQLGILRFLLGAADGaLLPAVQTLLV- 337
|
330 340
....*....|....*....|....*.
gi 727167453 360 aFPAEVRFTGISFSYNVSYAIFGGLT 385
Cdd:PRK09874 338 -YNSSNQIAGRIFSYNQSFRDIGNVT 362
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-397 |
3.42e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 48.72 E-value: 3.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 72 LGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEH-VPRR 150
Cdd:cd17473 50 LFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLAS--------RALLGIGVAGIMTLATALIGDYfEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 151 R---IGFACGTLTAGLTVGILLGSVVATVinttlspqsiaggGWRIPFLLGGMFGLVAMYLRRWLQETpifieMQARKAL 227
Cdd:cd17473 122 RakmLGLQSAAMSLGGVVFLLLGGALAEI-------------GWRAPFLVYLLALPVLILVLLFLPEP-----ARKSKSA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 228 AEELPLKSVVLNHKReVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGA 307
Cdd:cd17473 184 ASPGAATAAALPWKR-VLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 308 SKTLVVGSVLLAGCSWLFYQTVGVRpeMLFACYALVGFSVGVVgaVPYVMVRAF---PAEVRFTGISFsynVSYAIFGG- 383
Cdd:cd17473 263 RRLLAIGFALMALGFLLLALASGLW--VVLLGAILAGLGFGLL--LPTLNSWAMslvPPELRGRAMGI---VTSAFFLGq 335
|
330
....*....|....*
gi 727167453 384 -LTPIFVTLIMKLTP 397
Cdd:cd17473 336 fLSPLVLGPLVNLTG 350
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
51-404 |
7.75e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 48.00 E-value: 7.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 51 PEWLRLVQTFgiFAAGYLarpLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIgiaaplllLLMRVLQGA 130
Cdd:cd17328 33 DSLAGLLQTV--FIISYM---VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQL--------LLFRALVGI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 131 AIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTtlspqsiAGGGWRIPFLLGGMFGLVAMYLRR 210
Cdd:cd17328 100 GEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQ-------ATGGWRWAFRVTGVLGVLLAILLL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 211 WlqetpiFIEMQARKALAEELPLKSVV---------LNHKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPA--- 278
Cdd:cd17328 173 L------FVREPPRGAAEGGVMAKSTAtsfladlkaLAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLssa 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 279 -LTLQANSIATIMLIAGCIVAGLSADRFGASKT---LVVGSVLLAGCSWLFYQTVGVRPEMLFACYALVGFSVGVV---- 350
Cdd:cd17328 247 dVGLIFGAITCIAGVLGVLLGGILADRLRRKTPradPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLslnw 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 727167453 351 GAVPYVMVRAFPAEVRFTGISFSYNVSYAIFGGLTPIFVTLIMKLTPLAPAYYV 404
Cdd:cd17328 327 APVFAILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDLLRQNKDSPL 380
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
72-373 |
7.81e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 47.57 E-value: 7.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 72 LGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVP-RR 150
Cdd:cd17315 49 IGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVG--------RFLLGLGVGLASVLVPLYISEIAPaKI 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 151 RigfacGTLTAGLTVGILLGSVVATVINTTLSpqSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIemqarkalaee 230
Cdd:cd17315 121 R-----GALGTLNQLMITFGILLAYLLGLALS--LSPPGWWRLMFALAAVPALLQLLLMFFLPESRALL----------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 231 lplksvvlnhkreVAVSMLLTWLLSaGIVVVILMTPTYLQKQFGIAPALTlqANSIATIMLIAGCIVAGLSADRFGASKT 310
Cdd:cd17315 183 -------------VGVGLQLLQQLT-GINAVMYYAPTIFKSAGGGTASIL--ASIIVGVVNLLATLVAIRLVDKVGRRPL 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727167453 311 LVVGSVLLAGCSWLFYQTVGVRPEMLFACYA--------LVGFSVGvVGAVPYVMV-RAFPAEVRFTGISFS 373
Cdd:cd17315 247 LLIGFAGMAASLLLLAIAFLLPALAKAAGWLallgillyIAAFAMG-AGPVPWLLLsEIFPLRIRGKGMAIA 317
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
72-392 |
7.83e-06 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 47.73 E-value: 7.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 72 LGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRR 151
Cdd:cd17362 54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVG--------RLIYGVGIGLAMHAAPVYIAETSPSHI 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 152 IGFACGTLTAGLTVGILLGSVVATVINTtlspqsiAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFiEMQARKALAeel 231
Cdd:cd17362 126 RGLLVSLKELFIVLGILLGYVSGYAFAD-------VVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW-QGNYRKPLI--- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 232 plksvvlnhkreVAVSMLLTWLLSaGIVVVILMTPTYLQKQ-FGIAPALTLQANSIATIMLIAgCIVAGLSADRFGASKT 310
Cdd:cd17362 195 ------------IGLGLVLFQQIT-GQPSVLYYAATIFKSAgFSAASDATLVSVGLGVFKLLM-TIVAVLLVDKLGRRPL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 311 LVVG------SVLLAGCSWLFYQ--TVGVRPEMLFACYALVG-FSVGvVGAVPYVMV-RAFPAEVRFTGISFSYNVSYAI 380
Cdd:cd17362 261 LLGGvsgmvvSLFLLAAYNLFVQmgPAGLAWLSLVALLLYVGaYQIS-FGPISWLMVsEIFPLRVRGRAIALAVLVNFGS 339
|
330
....*....|..
gi 727167453 381 FGGLTPIFVTLI 392
Cdd:cd17362 340 NALVSLAFLPLQ 351
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
72-373 |
1.29e-05 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 47.18 E-value: 1.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 72 LGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRR 151
Cdd:cd17359 51 IGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIA--------RIIGGLAVGGASALVPMYIAEVAPAEI 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 152 IGFACGTLTAGLTVGILLGSVVATVINTTLSPQSIAGGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALaeel 231
Cdd:cd17359 123 RGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGKPIL---- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 232 pLKSVVLnhkrevAVSMLLTwllsaGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIaGCIVAGLSADRFGASKTL 311
Cdd:cd17359 199 -IIGIGL------AIFQQFV-----GINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVI-FTIIAILLVDKVGRKPLL 265
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 312 VVGSV------LLAGCSWLFYQTVGVRPEMLFACYAL-VGFSVGVVGAVPYVMV-RAFPAEVRFTGISFS 373
Cdd:cd17359 266 LIGSIgmaislLLIGTAFYFAPGSQASGIVALVLILLfVAFFAMSWGPVTWVLLsEIFPNRIRGLAMGIA 335
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
62-404 |
2.14e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 62 IFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAAPLLLLLMRVLQGAAIGgevPGAWV 141
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFG---PARQA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 142 FVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVInttlspqsIAGGGWRIPFLLGG----MFGLVAMYLRRWLQETPI 217
Cdd:cd06173 116 LLPELVPKEQLVRANALNSLATQLARIIGPALGGLL--------VALLGPGGAFAINAlsflLSALLLLFIRRPPPAAPG 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 218 FIEMQARKALAEELplksVVLNHKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIV 297
Cdd:cd06173 188 ESSSLLLRDLREGL----RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 298 AGLSADRFGASKTLVVGSVLLAGCSWLFYqtVGVRPEMLFACYALVGFSVGVVGAVPYVMV-RAFPAEVRFTGISFsYNV 376
Cdd:cd06173 264 LGRLSKRRRRGRLLLIGALLLGLALLVLG--LSPSLWLLLAALFLLGLAGGLFNVPLNTLLqLRVPDELRGRVFSV-YNA 340
|
330 340
....*....|....*....|....*...
gi 727167453 377 SYAIFGGLTPIFVTLIMKLTPLAPAYYV 404
Cdd:cd06173 341 LNSGAMPLGALLAGLLADALGLSAVFLL 368
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
61-361 |
2.50e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 46.11 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 61 GIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllMRVLQGAAIGGEVPGAW 140
Cdd:cd17355 42 LAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLL-------WGLLGGGGAGTLAAVAF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 141 VFVAEHVPRRRIGFACGTLTAGLTVGILLGSvvatvintTLSPQSIAGGGWRIPFLLGGMFGLVAM-----YLRRWLqet 215
Cdd:cd17355 115 ATVAAWWFERRRGLALGILTAGGGLGSLVFL--------PLGAALIEAFGWRTALLVLALLALLVLvpvllLLRRRP--- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 216 pifiemqARKALAEELPLKSVVLNHKREVAVSMLLTWLLSAGIVV-------VILMTPTYLQkQFGIAPALTLQANSIAT 288
Cdd:cd17355 184 -------ADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLcgfavvgLIVHLVPYLA-DRGISPAAAAVALALIG 255
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727167453 289 IMLIAGCIVAGLSADRFGASKTLVVgSVLLAGCSWLFYQTVGVRPEMLFACYALVGFSVGVVGAVPYVMVRAF 361
Cdd:cd17355 256 LFNIVGRLLSGWLGDRYSPRRLLAA-SYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARY 327
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
58-352 |
4.23e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 45.64 E-value: 4.23e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 58 QTFGIFAAGYLarpLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAaplllllmRVLQGAAIGGEVP 137
Cdd:cd17320 38 LTLSAYLLGFA---LGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIA--------RFLQGLGAAAGSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 138 GAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTTlspqsiagGGWRIPFL-LGGMFGLVAMYLRRWLQETp 216
Cdd:cd17320 107 VARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLF--------FGWRAIFVfLALLGLLLLLLVLLFLPET- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 217 ifiemqaRKALAEELPLKSVVLNHK-----REVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIML 291
Cdd:cd17320 178 -------LPEEKRKPLLSSLLRAYKrvlknRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIAL 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727167453 292 IAGCIVAGLSADRFGASKTLVVGSVLLAGCS---WLFYQTVGVRPEMLFACYALVGFSVGVVGA 352
Cdd:cd17320 251 ILGSLLNGRLVRRFGPRRLLRLGLLLLLAAAlvlLLAALLGGLSLWPLVAPLFLIFFGFGLIFP 314
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
169-348 |
4.35e-05 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 45.53 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 169 LGSVVATVINTTL--SPQSI----AGGGWRIPFLLGGM-FGLVAMYLRRWLQETPIFIEMQARKALAEELP-LKSVV--L 238
Cdd:COG2270 155 LGGVLLLLINLALflKPEAFglpdAGEAVRISFLLTALwWLLFALPLFLFLPERPRPGPAPPRGAVRAGFReLRRTLreL 234
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 239 NHKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLL 318
Cdd:COG2270 235 RRYRDLLRFLLAYFFYRDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIW 314
|
170 180 190
....*....|....*....|....*....|
gi 727167453 319 AGCSWLFYQTvgVRPEMLFACYALVGFSVG 348
Cdd:COG2270 315 IVVCLAAYFL--TTALAFWILGLLIGLVMG 342
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
75-404 |
6.09e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 6.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 75 IVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIgiaaplllLLMRVLQGAAIGGEVPGAWVFVAEHVPRRRIGF 154
Cdd:cd17474 52 PVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL--------LAGRALQGIGAAGLGPLALTLIGDLFEGGERAK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 155 ACGTLTAGLTVGILLGSVVATVInttlspqsiAGGGWRIPFLLGGMFGLVAMYLRRWLQETPifiEMQARKALAEELPLK 234
Cdd:cd17474 124 AMGLYEAALGLGIAVGPLLGGLL---------AAISWRYPFFLLAALIPVAFLAILFLLPEP---KEKAKSSSATKLRDL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 235 SVVLNHKReVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAG-LSADRFGASKTLVV 313
Cdd:cd17474 192 KKALRGRG-LLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVI 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 314 GSVLLAGCSWLFYQTVGvrPEMLFACYALVGFSVGVV-GAVPYVMVRAFPAEVRFTGISFsYNVSYAIFGGLTPIFVTLI 392
Cdd:cd17474 271 GLLLYALSLLLLGFVPS--LALLLIAIVLFGLGLGLNlPLLTTLVTELAPEEERGTASSL-YNFVRFLGQAVGPLLFGLL 347
|
330
....*....|..
gi 727167453 393 MKLTPLAPAYYV 404
Cdd:cd17474 348 LEIFGLSAPFLV 359
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
68-373 |
2.03e-04 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 43.33 E-value: 2.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 68 LARPLGGIVMAHFGDLVGRKKmftlSILLMALPTLAMGLLPTYASigiaAPLLLLLMRVLQGAAIGGEVPGAWVFVAEHV 147
Cdd:cd17358 52 LGALIGALLSGKLADRIGRKR----TLLISAIPCILGWLLIAFAK----DVWMLYLGRFLAGFGGGAASVVVPVYIAEIA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 148 PRRRIGFACGTLTAGLTVGILLGSVVATVINttlspqsiagggWRIPFLLGGMFGLVAMYLRRWLQETPIFIEM-----Q 222
Cdd:cd17358 124 PKNVRGALGSLNQLLVNIGILLGYVLGSFLP------------WRTLALIGAIPPVVFLILLFFIPESPRWLAKkgreeE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 223 ARKALAEELPLKSVVLNHKREVAVSMLLTWLLSAGIVVVILMTPTYLqKQFGIAPALTL-------------------QA 283
Cdd:cd17358 192 AEKSLQFLRGKDADISKEAAEIQEELAELEKEAKESSFSDLFQRKYL-KPLVIGLGLMLfqqlsginavifyassifdEA 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 284 NS-----IATIML----IAGCIVAGLSADRFG-------ASKTLVVGSVLLAGCSWL-----FYQTVGVRPEMLFACYaL 342
Cdd:cd17358 271 GSgldpnTATIIIgvvqVVGTLVATLLVDRLGrrplllvSAIGMGIGLLALGLYFYLqehgaLLSSVSWLPLVGLVIY-I 349
|
330 340 350
....*....|....*....|....*....|..
gi 727167453 343 VGFSVGvVGAVPYV-MVRAFPAEVRFTGISFS 373
Cdd:cd17358 350 ISFSIG-LGPLPWViMSEIFPAKIKGLAGSLV 380
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-230 |
2.54e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 43.08 E-value: 2.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 53 WLR-LVQTfgIFAAGYLarpLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIaaplllllMRVLQGAA 131
Cdd:TIGR00898 127 WKVdLTQS--CFFVGVL---LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLV--------FRLLVGMG 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 132 IGGEVPGAWVFVAEHVPR--RRIgfaCGTL-TAGLTVGILLGSVVATVINttlspqsiaggGWRIPFLLGGMFGLVAMYL 208
Cdd:TIGR00898 194 IGGIWVQAVVLNTEFLPKkqRAI---VGTLiQVFFSLGLVLLPLVAYFIP-----------DWRWLQLAVSLPTFLFFLL 259
|
170 180
....*....|....*....|..
gi 727167453 209 RRWLQETPIFIEMQARKALAEE 230
Cdd:TIGR00898 260 SWFVPESPRWLISQGRIEEALK 281
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-206 |
6.13e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.78 E-value: 6.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 19 LAALGGALEFYdFIIFVFFAAVVGDLFFPADMPEWLRLVQTFGIFAAG------YLARPLGGIVMAHFGDLVGRKKMFTL 92
Cdd:COG2271 173 PGLLLALLRFW-LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGlllslpFLAGIVGSLLGGWLSDRLGRRRKLVL 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 93 SI--LLMALPTLAMGLLPTYASIGIAAplllllmrVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLG 170
Cdd:COG2271 252 AIglLLAALALLLLALLPSPALAIALL--------FLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALG 323
|
170 180 190
....*....|....*....|....*....|....*.
gi 727167453 171 SVVATVInttlspqsIAGGGWRIPFLLGGMFGLVAM 206
Cdd:COG2271 324 PLLVGYL--------LDATGYQAAFLLLAALALLAA 351
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
251-386 |
7.81e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.40 E-value: 7.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 251 TWLLSAGIVVVIL-MTPT---------YLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAG 320
Cdd:COG2807 16 RWLLLLAIVLVALnLRPAitsvgpllpEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 727167453 321 CSWLFYQTVGVrpEMLFACYALVGFSVGVVGAV-PYVMVRAFPAEVRF-TGI-SFSYNVSYAIFGGLTP 386
Cdd:COG2807 96 GLLLRSLAPSV--ALLLAGTALIGAGIAVGNVLlPGLIKRWFPDRVGLmTGLyTAAMGLGAALAAGLTV 162
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
31-216 |
1.05e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.02 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 31 FIIFVFFAAVVGDLFFPADMPEWLRLVQTFGIFAAgyLARPLGGIvmahFGDLVGRKKMFTLSILLMALPTLAMGLLPTY 110
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA--LGRPLGGW----LSDRIGGRRVLLIVFALMALGLLLLALALGS 294
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 111 ASIGIAAplllllmRVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTtlspqsiAGGG 190
Cdd:COG2223 295 LWLFLVL-------FLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD-------ATGS 360
|
170 180
....*....|....*....|....*.
gi 727167453 191 WRIPFLLGGMFGLVAMYLRRWLQETP 216
Cdd:COG2223 361 YTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
68-365 |
1.13e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 41.08 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 68 LARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLptyasigIAAPLLLLLMRVLQGAAIGGEVPGAwVFVAEHV 147
Cdd:cd17341 45 LAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALA-------VSSYWGLLVLGFLLGFAGANFASGQ-PWASFWF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 148 PRRRIGFACGTLTAGLTVGILLGSVVATVINTTLSpQSIAGGGWRIPFLLGGMFGLVAMYLR-RWLQETPifiemQARKA 226
Cdd:cd17341 117 PKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIV-FDGGFVGWRNAFFVPGILLAIAAVLVlLFGDDLP-----TGKAS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 227 LAEELPLKSVVLNHKREVAVSmlLTWLLSAGIVVVI-LMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRF 305
Cdd:cd17341 191 ALEFLKVQLAVLKNYRTWILS--LLYGVTFGSFVGFsNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRF 268
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 727167453 306 GASKTLVVGSVLLAGCSWLFYQTVGVRPEMLFACYAL---VGFSVGVV-GAVPYVMVRAFPAEV 365
Cdd:cd17341 269 GGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLALfvaLGLGAGAGnGSVFRMVPFIFRREL 332
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
248-421 |
1.30e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 248 MLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKTLVVGSVLLAGCSWLFYQ 327
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 328 TVGVrpEMLFACYALVGFSVGVVGAVPYVMV-RAFPAEVRFTGISFsYNVSYAIFGGLTPIFVTLIMKLTPLAPAYYVLA 406
Cdd:pfam07690 82 ASSL--WLLLVLRVLQGLGAGALFPAALALIaDWFPPEERGRALGL-VSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|....*
gi 727167453 407 LSLIGLLLGVYLHRD 421
Cdd:pfam07690 159 ILSLLAAVLLLLPRP 173
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
72-322 |
1.34e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 40.68 E-value: 1.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 72 LGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIAAplllllmrVLQGAAIGGEVPGAWVFVAEHVPRRR 151
Cdd:cd17475 46 VSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLL--------FLVGAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 152 IGFACGTLTAGLTVGILLGSVVATVINTTLspqsiaggGWRIPFLLGGMFGLVAMYLR-RWLQETPIFIeMQARKALAEE 230
Cdd:cd17475 118 RGLAMGIRQTGVPLGGALAAALLPPLALHY--------GWRAAFVVAGLVSILAAVLFwLFYREPPAAS-AATESASTLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 231 LPLKSVVLNhkREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVAGLSADRF--GAS 308
Cdd:cd17475 189 RSLKEVLRN--RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRR 266
|
250
....*....|....
gi 727167453 309 KTLVVGSVLLAGCS 322
Cdd:cd17475 267 RPVLVITAAIAAAA 280
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
56-409 |
1.37e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 40.64 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 56 LVQTfgIFAAGYLarpLGGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASigiaapllLLLMRVLQGAAIGGE 135
Cdd:cd17317 29 LVQT--IFFLGVL---IGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL--------FLVLRFLVGVTSAGI 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 136 VPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTtlspqsiagggWRIPFLLGGMFGLVAMYLRRWLqet 215
Cdd:cd17317 96 FTVGFVLGMEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD-----------WRWLQLAISLPGLLFLLLLWWL--- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 216 pifiemqarkalaeelPLKSVVlnhkrevavsMLLTWLLSAGIVVVILMTPTYLQKQFgiapaltLQANSIATIMLIAGC 295
Cdd:cd17317 162 ----------------PRRTII----------VGLIWFVTSLVYYGLSLNSSNLGGNL-------YLNFFLSGLVEIPAY 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 296 IVAGLSADRFGaSKTLVVGSVLLAGCSWLFYQTVGVRPEMLFACYALVG-FSVGVVGAVPYV-MVRAFPAEVRFTGISFS 373
Cdd:cd17317 209 FLALLLLDRLG-RRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGkFAISAAFSVIYLyTAELYPTVVRNTGVGLC 287
|
330 340 350
....*....|....*....|....*....|....*.
gi 727167453 374 ynVSYAIFGGLTPIFVTLIMKLTPLAPAYYVLALSL 409
Cdd:cd17317 288 --STVARVGAILAPFIVLLGKIGPLLPLIIFGVLAL 321
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
61-215 |
2.19e-03 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 38.40 E-value: 2.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 61 GIFAAGYLARPL-GGIVMAHFGDLVGRKKMFTLSILLMALPTLAMGLLPTYASIGIaaplllllMRVLQGAAIGGEVPGA 139
Cdd:TIGR00880 1 GLLLAGYALGQLiYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLII--------ARFLQGFGAAFALVAG 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727167453 140 WVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVInttlspqsIAGGGWRIPFLLGGMFGLVAMYLR-RWLQET 215
Cdd:TIGR00880 73 AALIADIYPPEERGVALGLMSAGIALGPLLGPPLGGVL--------AQFLGWRAPFLFLAILALAAFILLaFLLPET 141
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
29-206 |
2.62e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.83 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 29 YDFIIFVFFAAVVGDLFFPADMP------EWLRLVQTFGIFAAGYLARPLGGIVMAHFGDLVGRKKMFTLSILLMALPTL 102
Cdd:cd17370 200 KAFWLYLLAVALFALGNFSFAFLilraqeLGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 103 AMGLLPTYASIGIAAplllllmrVLQGAAIGGEVPGAWVFVAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVINTTLS 182
Cdd:cd17370 280 GFALGSSLWLLLLGF--------ILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS 351
|
170 180
....*....|....*....|....
gi 727167453 183 PQsiagggwrIPFLLGGMFGLVAM 206
Cdd:cd17370 352 PS--------AAFLFSAVLALIAL 367
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
153-353 |
3.93e-03 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 39.12 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 153 GFACGTLTAGLTVGILLGSVVATVINTTLSpqsiagggWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAEELP 232
Cdd:cd17486 126 GAGAGVRVNGYRIGMLVAGAGALYLADSLS--------WSAVYLIMAALMGPGILATLFAPEPPRTDPPANSLSETVVAF 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 233 LKSVVLNHKREVAVSMLLTWLL--SAGIVVVILMTPTYLQKQFgIAPALTLQANSIATIMLIAGCIVAGLSADRFGASKT 310
Cdd:cd17486 198 FAPFKDFFGQPGALLILAFILLykLGDAMLGAMATPFLLDLGF-TKTEIGAVYKTVGLIATIVGGLLGGFLMSRLGLKRS 276
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 727167453 311 LVVGSVLLAGCSWLFYQTVGVRPE--MLFACYALVGFSVGVVGAV 353
Cdd:cd17486 277 LWLFGILQALSNLGFIYLAHAGPNltLLVAAVAVENFGGGLGTTA 321
|
|
| SP |
TIGR00879 |
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ... |
18-393 |
4.80e-03 |
|
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273317 [Multi-domain] Cd Length: 481 Bit Score: 39.24 E-value: 4.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 18 TLAALGGALEFYD-FIIFVFFAAVVGDLFFPADMPEWLRLVQTfGIFAAGYLarpLGGIVMAHFGDLVGRKKMFTLSILL 96
Cdd:TIGR00879 31 LIAAIGGLMFGYDtGVIGGALALPAFEFKFTSANSDSYSSSLW-GLVVSIFL---VGGFIGALFAGWLSDRFGRKKSLLI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 97 MALPTLAMGLLPTYASIGIAAPLLLLLmRVLQGAAIGGEVPGAWVFVAEHVPRRrIGFACGTLTA-GLTVGILLGSVVAT 175
Cdd:TIGR00879 107 IALLFVIGAILMGLAAFALSVEMLIVG-RVLLGIGVGIASALVPMYLSEIAPKA-LRGALTSLYQlAITFGILVAYGFGS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 176 VINTTLSPqsiagGGWRIPFLLGGMFGLVAMYLRRWLQETPIFIEMQARKALAEE------------------------- 230
Cdd:TIGR00879 185 GKVSLNNT-----LGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKslarlrgtsgedkelldelelidik 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 231 ------------LPLKSVVLNHKREVAVSMLLTWLLSAGIVVVILMTPTYLQKQFGIAPALTLQANSIATIMLIAGCIVA 298
Cdd:TIGR00879 260 rsiekrsvqpswGSLFSSTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSIIVGAVNFAFTFVA 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 299 GLSADRFGASKTLVVGSVLLAGCSW----LFYQTVGVRPE-----MLFACYALVGFSVGVVGAVPYVMV-RAFPAEVRft 368
Cdd:TIGR00879 340 IFLVDRFGRRPLLLIGAAGMAICLFvlgiLGASFVTGSSKssgnvAIVFILLFIAFFAMGWGPVPWVIVsEIFPLSLR-- 417
|
410 420
....*....|....*....|....*
gi 727167453 369 GISFSYNVSYAIFGGLTPIFVTLIM 393
Cdd:TIGR00879 418 PKGISIAVAANWLANFIVGFLFPTM 442
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
63-312 |
9.79e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 37.92 E-value: 9.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 63 FAAGYLarpLGGIVMAHFGDLVGRKKMFTLSILLMALPTLamgLLPTYASIGIAApllLLLMRVLQGAAIGGEVPGAWVF 142
Cdd:cd17380 43 FFWGYA---LTQVLGGYLADRFGGKKVLLLAVALWSLATL---LTPLLAYSSLPL---LILSRILLGLGEGVHFPSMTSL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 143 VAEHVPRRRIGFACGTLTAGLTVGILLGSVVATVInttlspqsIAGGGWRIPFLLGGMFGLVAMYLRRWLqetpifiemq 222
Cdd:cd17380 114 FSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLL--------LEYYGWPSVFYFFGLLGLLWALVWLIY---------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727167453 223 arkalaeELPLKSVVLNHkrevaVSM------LLTWLlsagivvvilmtPTYLQKQFGiapALTLQA--NSIATIMLIAG 294
Cdd:cd17380 176 -------LPPVWAIIVAH-----FCMnwgfyiLLSWL------------PTYFHEVLV---PLAKGWvfNVVPWLVMFPS 228
|
250 260
....*....|....*....|.
gi 727167453 295 CIVAGLSADRF---GASKTLV 312
Cdd:cd17380 229 SNVAGWLADHLisrGWTVTSV 249
|
|
| |
