|
Name |
Accession |
Description |
Interval |
E-value |
| mpl |
TIGR01081 |
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; Alternate name: ... |
2-450 |
0e+00 |
|
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; Alternate name: murein tripeptide ligase [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 130153 [Multi-domain] Cd Length: 448 Bit Score: 819.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 2 RIHILGICGTFMGGLAMLARSLGHDVTGSDANVYPPMSTLLENQGIDLIQGYDPAQLDPAPDLVIIGNAMTRGNPCVEAV 81
Cdd:TIGR01081 1 HIHILGICGTFMGGLAMIAKQLGHEVTGSDANVYPPMSTQLEAQGIEIIEGFDAAQLEPKPDLVVIGNAMKRGNPCVEAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 82 LERGIPYVSGPQWLHDAVLRDRWVLAVAGTHGKTTTAGMATWILEACGYQPGFVIGGVPGNFDVSARLGGSPFFVIEADE 161
Cdd:TIGR01081 81 LNLNLPYTSGPQWLHDFVLHDRWVLAVAGTHGKTTTASMLAWVLEQCGLKPGFLIGGVPGNFGVSARLGESPFFVIEADE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 162 YDCAFFDKRSKFVHYSPRTLIMNNLEFDHADIFDDLKAIQKQFHHLVRLVPGKGKIILPDNDSHLKQVMAMGCWSEQELV 241
Cdd:TIGR01081 161 YDTAFFDKRSKFVHYRPRTLVLNNLEFDHADIFDDLKAIQRQFHHLVRTVPGEGLILCPGRDQSLKDTLAKGCWSEQEFF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 242 GEEGTWRAQKLTPDASHYAVFLDGEQVGEVNWALVGEHNMHNGLMAIAATRHVGVQPADACRALGDFINARRRLELRGEA 321
Cdd:TIGR01081 241 GEQGEWQAEKITADGSHFDVLLDGEKVGEVKWSLVGRHNMHNALMAIAAARHVGVAIEDACEALGSFVNAKRRLELKGEA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 322 NGVTVYDDFAHHPTAILATLAALRGKVGGtARILAVLEPRSNTMKMGISKNDLAPSLGRADEVFLFQPHHIPWQVAEVAD 401
Cdd:TIGR01081 321 NGITVYDDFAHHPTAIEATLQGLRQKVGG-ARILAVLEPRSNTMKLGVHKDDLAPSLGRADQVFLYQPGQIPWDVAEVAA 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 727166820 402 ACVQPAHWSADLDTLVDMVVKTAQPGDHILVMSNGGFGGIHDRLLDALA 450
Cdd:TIGR01081 400 QCVQPANVSADFDAFVAMIVKNAQPGDHILVMSNGGFGGIHGKLLDALR 448
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
1-447 |
0e+00 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 584.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 1 MRIHILGICGTFMGGLAMLARSLGHDVTGSDANVYPpMSTLLENQGIDLIQGYDPAQLDpAPDLVIIGNAMTRGNPCVEA 80
Cdd:COG0773 5 MHIHFIGIGGIGMSGLAEILLALGYKVSGSDLAESP-MTERLEALGIPVFIGHDAENID-DADLVVVSSAIPRDNPELVA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 81 VLERGIPYVSGPQWLHDaVLRDRWVLAVAGTHGKTTTAGMATWILEACGYQPGFVIGGVPGNFDVSARLGGSPFFVIEAD 160
Cdd:COG0773 83 ARERGIPVLSRAEMLAE-LMRGKRSIAVAGTHGKTTTTSMLAHILEEAGLDPTFLIGGILNNFGTNARLGDGDYFVAEAD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 161 EYDCAFfdkrskfVHYSPRTLIMNNLEFDHADIFDDLKAIQKQFHHLVRLVPGKGKIILPDNDSHLKQVMAMgCWSEQEL 240
Cdd:COG0773 162 ESDGSF-------LHYSPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPR-CGRPVIT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 241 VG--EEGTWRAQKLTPDA--SHYAVFLDGEQVGEVNWALVGEHNMHNGLMAIAATRHVGVQPADACRALGDFINARRRLE 316
Cdd:COG0773 234 YGfsEDADYRAENIRIDGggSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 317 LRGEANGVTVYDDFAHHPTAILATLAALRGKVGGtARILAVLEPRSNTMkMGISKNDLAPSLGRADEVFLFQPHH----- 391
Cdd:COG0773 314 LKGEVGGVTVIDDYAHHPTEIAATLAAAREKYPD-RRLVAVFQPHRYSR-TRDFLDEFAEALSLADEVILLDIYAarekp 391
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 392 IP-WQVAEVADAC---VQPAHWSADLDTLVDMVVKTAQPGDHILVMSNGGFGGIHDRLLD 447
Cdd:COG0773 392 IPgVSSEDLAEAIrkrGKDVVYVPDLDELVEALAEIARPGDVVLTMGAGDIGGLGEKLLE 451
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
4-386 |
5.78e-32 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 129.55 E-value: 5.78e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 4 HILGICGTFMGGLAMLARSLGHDVTGSDANVYPPMSTLlENQGIDLIQGYDPAQLdPAPDLVIIGNAMTRGNPCVEAVLE 83
Cdd:PRK14573 8 HFIGIGGIGMSALAHILLDRGYSVSGSDLSEGKTVEKL-KAKGARFFLGHQEEHV-PEDAVVVYSSSISKDNVEYLSAKS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 84 RGIPYVSGPQWLHDaVLRDRWVLAVAGTHGKTTTAGMATWILEACGYQPGFVIGGVPGNFdVSARLGGSPFFVIEADEYD 163
Cdd:PRK14573 86 RGNRLVHRAELLAE-LMQEQISILVSGSHGKTTVSSLITAIFQEAKKDPSYAIGGLNQEG-LNGYSGSSEYFVAEADESD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 164 caffdkrSKFVHYSPRTLIMNNLEFDHADIFD-DLKAIQKQFHHLVRLVPGKGKIILPDNDSHLK---QVMAMGCWSEQE 239
Cdd:PRK14573 164 -------GSLKHYTPEFSVITNIDNEHLSNFEgDRELLLASIQDFARKVQQINKCFYNGDCPRLKgclQGHSYGFSSSCD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 240 L----VGEEGtWRaqkltpdaSHYAVFLDGEQVGEVNWALVGEHNMHNGLMAIAATRHVGVQPADACRALGDFINARRRL 315
Cdd:PRK14573 237 LhilsYYQEG-WR--------SYFSAKFLGVVYQDIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727166820 316 ELRGEANGVTVYDDFAHHPTAILATLAALRGKVgGTARILAVLEP-RSNTMKMGIskNDLAPSLGRADEVFL 386
Cdd:PRK14573 308 ERKNSSETFLFLEDYAHHPSEISCTLRAVRDAV-GLRRIIAICQPhRFSRLRECL--DSFPSAFQDADEVIL 376
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
2-103 |
8.17e-17 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 74.96 E-value: 8.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 2 RIHILGICGTFMGGLAMLARSLGHDVTGSDANVYppmstlLENQGIDLIQGYDPAqldpapdlviigNAMTRGNPCVEAV 81
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIES------LIALGAAAVVGHDAA------------NNISPDNPELEAA 62
|
90 100
....*....|....*....|..
gi 727166820 82 LERGIPYVSGPQWLHDAVLRDR 103
Cdd:pfam01225 63 KVPGIPVIDRREALAELAAAFY 84
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| mpl |
TIGR01081 |
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; Alternate name: ... |
2-450 |
0e+00 |
|
UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase; Alternate name: murein tripeptide ligase [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 130153 [Multi-domain] Cd Length: 448 Bit Score: 819.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 2 RIHILGICGTFMGGLAMLARSLGHDVTGSDANVYPPMSTLLENQGIDLIQGYDPAQLDPAPDLVIIGNAMTRGNPCVEAV 81
Cdd:TIGR01081 1 HIHILGICGTFMGGLAMIAKQLGHEVTGSDANVYPPMSTQLEAQGIEIIEGFDAAQLEPKPDLVVIGNAMKRGNPCVEAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 82 LERGIPYVSGPQWLHDAVLRDRWVLAVAGTHGKTTTAGMATWILEACGYQPGFVIGGVPGNFDVSARLGGSPFFVIEADE 161
Cdd:TIGR01081 81 LNLNLPYTSGPQWLHDFVLHDRWVLAVAGTHGKTTTASMLAWVLEQCGLKPGFLIGGVPGNFGVSARLGESPFFVIEADE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 162 YDCAFFDKRSKFVHYSPRTLIMNNLEFDHADIFDDLKAIQKQFHHLVRLVPGKGKIILPDNDSHLKQVMAMGCWSEQELV 241
Cdd:TIGR01081 161 YDTAFFDKRSKFVHYRPRTLVLNNLEFDHADIFDDLKAIQRQFHHLVRTVPGEGLILCPGRDQSLKDTLAKGCWSEQEFF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 242 GEEGTWRAQKLTPDASHYAVFLDGEQVGEVNWALVGEHNMHNGLMAIAATRHVGVQPADACRALGDFINARRRLELRGEA 321
Cdd:TIGR01081 241 GEQGEWQAEKITADGSHFDVLLDGEKVGEVKWSLVGRHNMHNALMAIAAARHVGVAIEDACEALGSFVNAKRRLELKGEA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 322 NGVTVYDDFAHHPTAILATLAALRGKVGGtARILAVLEPRSNTMKMGISKNDLAPSLGRADEVFLFQPHHIPWQVAEVAD 401
Cdd:TIGR01081 321 NGITVYDDFAHHPTAIEATLQGLRQKVGG-ARILAVLEPRSNTMKLGVHKDDLAPSLGRADQVFLYQPGQIPWDVAEVAA 399
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 727166820 402 ACVQPAHWSADLDTLVDMVVKTAQPGDHILVMSNGGFGGIHDRLLDALA 450
Cdd:TIGR01081 400 QCVQPANVSADFDAFVAMIVKNAQPGDHILVMSNGGFGGIHGKLLDALR 448
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
1-447 |
0e+00 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 584.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 1 MRIHILGICGTFMGGLAMLARSLGHDVTGSDANVYPpMSTLLENQGIDLIQGYDPAQLDpAPDLVIIGNAMTRGNPCVEA 80
Cdd:COG0773 5 MHIHFIGIGGIGMSGLAEILLALGYKVSGSDLAESP-MTERLEALGIPVFIGHDAENID-DADLVVVSSAIPRDNPELVA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 81 VLERGIPYVSGPQWLHDaVLRDRWVLAVAGTHGKTTTAGMATWILEACGYQPGFVIGGVPGNFDVSARLGGSPFFVIEAD 160
Cdd:COG0773 83 ARERGIPVLSRAEMLAE-LMRGKRSIAVAGTHGKTTTTSMLAHILEEAGLDPTFLIGGILNNFGTNARLGDGDYFVAEAD 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 161 EYDCAFfdkrskfVHYSPRTLIMNNLEFDHADIFDDLKAIQKQFHHLVRLVPGKGKIILPDNDSHLKQVMAMgCWSEQEL 240
Cdd:COG0773 162 ESDGSF-------LHYSPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYGLLVLCADDPGLRELLPR-CGRPVIT 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 241 VG--EEGTWRAQKLTPDA--SHYAVFLDGEQVGEVNWALVGEHNMHNGLMAIAATRHVGVQPADACRALGDFINARRRLE 316
Cdd:COG0773 234 YGfsEDADYRAENIRIDGggSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRFE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 317 LRGEANGVTVYDDFAHHPTAILATLAALRGKVGGtARILAVLEPRSNTMkMGISKNDLAPSLGRADEVFLFQPHH----- 391
Cdd:COG0773 314 LKGEVGGVTVIDDYAHHPTEIAATLAAAREKYPD-RRLVAVFQPHRYSR-TRDFLDEFAEALSLADEVILLDIYAarekp 391
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 392 IP-WQVAEVADAC---VQPAHWSADLDTLVDMVVKTAQPGDHILVMSNGGFGGIHDRLLD 447
Cdd:COG0773 392 IPgVSSEDLAEAIrkrGKDVVYVPDLDELVEALAEIARPGDVVLTMGAGDIGGLGEKLLE 451
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
2-446 |
1.79e-82 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 261.47 E-value: 1.79e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 2 RIHILGICGTFMGGLAMLARSLGHDVTGSDANVYPpMSTLLENQGIDLIQGYDPAQLDPaPDLVIIGNAMTRGNPCVEAV 81
Cdd:TIGR01082 1 KIHFVGIGGIGMSGIAEILLNRGYQVSGSDIAENA-TTKRLEALGIPIYIGHSAENLDD-ADVVVVSAAIKDDNPEIVEA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 82 LERGIPYVSGPQWLHDaVLRDRWVLAVAGTHGKTTTAGMATWILEACGYQPGFVIGGVPGNFDVSARLGGSPFFVIEADE 161
Cdd:TIGR01082 79 KERGIPVIRRAEMLAE-LMRFRHSIAVAGTHGKTTTTAMIAVILKEAGLDPTVVVGGLVKEAGTNARLGSGEYLVAEADE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 162 YDcaffdkrSKFVHYSPRTLIMNNLEFDHADIF-DDLKAIQKQFHHLVRLVPGKGKIILPDNDSHLKQVMAMGcwSEQEL 240
Cdd:TIGR01082 158 SD-------ASFLHLQPNVAIVTNIEPDHLDTYgSSFERLKAAFEKFIHNLPFYGLAVICADDPVLRELVPKA--TEQVI 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 241 V----GEEGTWRAQK--LTPDASHYAVFLDGEQVGEVNWALVGEHNMHNGLMAIAATRHVGVQPADACRALGDFINARRR 314
Cdd:TIGR01082 229 TyggsGEDADYRAENiqQSGAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRR 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 315 LELRGEANGVTVYDDFAHHPTAILATLAALRGKvGGTARILAVLEPR--SNTMKmgiSKNDLAPSLGRADEVFL------ 386
Cdd:TIGR01082 309 FEILGEFGGVLLIDDYAHHPTEIKATLKAARQG-YPDKRIVVVFQPHrySRTRD---LFDDFAKVLSDADELILldiyaa 384
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727166820 387 ----FQPHHIpwqvAEVADACVQPAHWSA----DLDTLVDMVVKTAQPGDHILVMSNGGFGGIHDRLL 446
Cdd:TIGR01082 385 geepINGIDG----KSLARKITQLGKIEPyfvpDLAELVEFLAAVLQSGDLILTMGAGDIIKLARELL 448
|
|
| PRK14573 |
PRK14573 |
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase; |
4-386 |
5.78e-32 |
|
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
Pssm-ID: 184752 [Multi-domain] Cd Length: 809 Bit Score: 129.55 E-value: 5.78e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 4 HILGICGTFMGGLAMLARSLGHDVTGSDANVYPPMSTLlENQGIDLIQGYDPAQLdPAPDLVIIGNAMTRGNPCVEAVLE 83
Cdd:PRK14573 8 HFIGIGGIGMSALAHILLDRGYSVSGSDLSEGKTVEKL-KAKGARFFLGHQEEHV-PEDAVVVYSSSISKDNVEYLSAKS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 84 RGIPYVSGPQWLHDaVLRDRWVLAVAGTHGKTTTAGMATWILEACGYQPGFVIGGVPGNFdVSARLGGSPFFVIEADEYD 163
Cdd:PRK14573 86 RGNRLVHRAELLAE-LMQEQISILVSGSHGKTTVSSLITAIFQEAKKDPSYAIGGLNQEG-LNGYSGSSEYFVAEADESD 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 164 caffdkrSKFVHYSPRTLIMNNLEFDHADIFD-DLKAIQKQFHHLVRLVPGKGKIILPDNDSHLK---QVMAMGCWSEQE 239
Cdd:PRK14573 164 -------GSLKHYTPEFSVITNIDNEHLSNFEgDRELLLASIQDFARKVQQINKCFYNGDCPRLKgclQGHSYGFSSSCD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 240 L----VGEEGtWRaqkltpdaSHYAVFLDGEQVGEVNWALVGEHNMHNGLMAIAATRHVGVQPADACRALGDFINARRRL 315
Cdd:PRK14573 237 LhilsYYQEG-WR--------SYFSAKFLGVVYQDIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRL 307
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727166820 316 ELRGEANGVTVYDDFAHHPTAILATLAALRGKVgGTARILAVLEP-RSNTMKMGIskNDLAPSLGRADEVFL 386
Cdd:PRK14573 308 ERKNSSETFLFLEDYAHHPSEISCTLRAVRDAV-GLRRIIAICQPhRFSRLRECL--DSFPSAFQDADEVIL 376
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
1-431 |
2.44e-23 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 102.08 E-value: 2.44e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 1 MRIHILGicgtfMG--GLAM--LARSLGHDVTGSDANVYPPMS-TLLENQGIDLIQGYDPAQLDPAPDLVII--GNAMTr 73
Cdd:COG0771 5 KKVLVLG-----LGksGLAAarLLAKLGAEVTVSDDRPAPELAaAELEAPGVEVVLGEHPEELLDGADLVVKspGIPPD- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 74 gNPCVEAVLERGIPYVSGPQ---WLHDAvlrdRWVlAVAGTHGKTTTAGMATWILEACGYQPGFViggvpGNFdvsarlg 150
Cdd:COG0771 79 -HPLLKAARAAGIPVIGEIElayRLSPA----PII-AITGTNGKTTTTTLIGHILKAAGLRVAVG-----GNI------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 151 GSPF--FVIEADEYDCaffdkrskFV------------HYSPRTLIMNNLEFDHADIFDDLKA-IQ-KQfhHLVRLVPGK 214
Cdd:COG0771 141 GTPLldLLLEPEPPDV--------YVlelssfqlettpSLRPDVAVILNITPDHLDRHGSMEAyAAaKA--RIFANQTPD 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 215 GKIILPDNDshlKQVMAMGCWSEQELVG-------EEGTW-RAQKLTPDASHYAVFldgeQVGEVnwALVGEHNMHNGLM 286
Cdd:COG0771 211 DYAVLNADD---PLTRALAEEAKARVVPfslkeplEGGAGlEDGKLVDRASGEELL----PVDDL--RLPGRHNLENALA 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 287 AIAATRHVGVQPADACRALGDFINARRRLELRGEANGVTVYDD-FAhhpTAILATLAALRG---KV----GGTARilavl 358
Cdd:COG0771 282 ALAAARALGVPPEAIREALRSFKGLPHRLEFVAEINGVRFINDsKA---TNPDATLAALESfdgPVvliaGGLDK----- 353
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727166820 359 eprsntmkmGISKNDLAPSL-GRADEVFLF---QPhhipwQVAEVADACVQPAHWSADLDTLVDMVVKTAQPGDHIL 431
Cdd:COG0771 354 ---------GADFSPLAPAVaERVKAVVLIgedAE-----KIAAALAGAGVPVVIVETMEEAVAAAAELARPGDVVL 416
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
2-431 |
5.86e-21 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 94.71 E-value: 5.86e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 2 RIHILGICGTfmgGLAMLA--RSLGHDVTGSD----ANVYPPMSTLLENQGIDLIQGYDPAQLDPApDLVIIGNAMTRGN 75
Cdd:TIGR01087 1 KILILGLGKT---GRAVARflHKKGAEVTVTDlkpnEELEPSMGQLRLNEGSVLHTGLHLEDLNNA-DLVVKSPGIPPDH 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 76 PCVEAVLERGIPYVSGPQWLHDavLRDRWVLAVAGTHGKTTTAGMATWILEACGyqPGFVIGGvpgNFDVSA----RLGG 151
Cdd:TIGR01087 77 PLVQAAAKRGIPVVGDIELFLR--LVPLPVVAITGTNGKTTTTSLLYHLLKAAG--LKAFLGG---NIGTPAlevlDQEG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 152 SPFFVIEAdeydcaffdkrSKF-VHYS----PRTLIMNNLEFDHADIFDDL----KAIQKQFHHLvrlvPGKGKIILPDN 222
Cdd:TIGR01087 150 AELYVLEL-----------SSFqLETTeslrPEIALILNISEDHLDWHGSFedyvAAKLKIFARQ----TEGDVAVLNAD 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 223 DSHLkqvmamgcwseqelVGEEGTWRAQKLTPDASHYA----VFLDGEQVGEVNWA---LVGEHNMHNGLMAIAATRHVG 295
Cdd:TIGR01087 215 DPRF--------------ARLAQKSKAQVIWFSVEKDAerglCIRDGGLYLKPNDLegsLLGLHNAENILAAIALAKSLG 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 296 VQPADACRALGDFINARRRLELRGEANGVTVYDDF-AHHPTAILATLAALRGKV----GGTAR---ILAVLEPRSNTMK- 366
Cdd:TIGR01087 281 LNLEAILEALRSFKGLPHRLEYVGQKNGVHFYNDSkATNVHATLAALSAFDNPVilivGGDDKgadFSPLAPAAAGKVKa 360
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727166820 367 ---MGISKNDLAPSLGRADEVFlfqphhipwQVAEVADACVQPAhwsadldtlvdmvVKTAQPGDHIL 431
Cdd:TIGR01087 361 vlaIGEDAAKIAPLLKEAGLSV---------YLVESLEEAVQAA-------------REVASPGDVVL 406
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
104-357 |
3.70e-18 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 86.29 E-value: 3.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 104 WVLAVAGTHGKTTTAGMATWILEACGYQPGfVIG----GVPGNF-----------DVSARLG-----GSPFFVIEA---- 159
Cdd:COG0769 81 KLIGVTGTNGKTTTTYLLAQILRALGKKTG-LIGtvgnGIGGELipsslttpealDLQRLLAemvdaGVTHVVMEVssha 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 160 ------D--EYDCAFFdkrskfvhysprtlimNNLEFDHADifddlkaiqkqFHH-----------LVRLVPGKGKIILP 220
Cdd:COG0769 160 ldqgrvDgvRFDVAVF----------------TNLTRDHLD-----------YHGtmeayfaakarLFDQLGPGGAAVIN 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 221 DNDSHLKQVMAM---GCWSeqelVG--EEGTWRAQKLTPDASHYAVFLDG-EQVGEVNWALVGEHNMHNGLMAIAATRHV 294
Cdd:COG0769 213 ADDPYGRRLAAAapaRVIT----YGlkADADLRATDIELSADGTRFTLVTpGGEVEVRLPLIGRFNVYNALAAIAAALAL 288
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727166820 295 GVQPADACRALGDFINARRRLELRGEANGVTVYDDFAHHPTAILATLAALRGKVGGtaRILAV 357
Cdd:COG0769 289 GIDLEEILAALEKLKGVPGRMERVDGGQGPTVIVDYAHTPDALENVLEALRPHTKG--RLIVV 349
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
2-103 |
8.17e-17 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 74.96 E-value: 8.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 2 RIHILGICGTFMGGLAMLARSLGHDVTGSDANVYppmstlLENQGIDLIQGYDPAqldpapdlviigNAMTRGNPCVEAV 81
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIES------LIALGAAAVVGHDAA------------NNISPDNPELEAA 62
|
90 100
....*....|....*....|..
gi 727166820 82 LERGIPYVSGPQWLHDAVLRDR 103
Cdd:pfam01225 63 KVPGIPVIDRREALAELAAAFY 84
|
|
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
190-454 |
1.82e-14 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 75.14 E-value: 1.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 190 HADIFDDLKAIQKQ----FHHLvrlvPGKGKIILPDNDSHLKQVMAMgcwSEQELV----GEEGTWRAQ--KLTPDASHY 259
Cdd:COG0770 188 HLEGFGSLEGIARAkgeiFEGL----PPGGVAVLNADDPLLAALAER---AKARVLtfglSEDADVRAEdiELDEDGTRF 260
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 260 AVFLDGEQVgEVNWALVGEHNMHNGLMAIAATRHVGVQPADACRALGDFINARRRLELRGEANGVTVYDDfAHH--PTAI 337
Cdd:COG0770 261 TLHTPGGEL-EVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDD-SYNanPDSM 338
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 338 LATLAALrGKVGGTARILAVL----E--PRSNTM--KMGisknDLAPSLGrADEVFLFQPHhipwqVAEVADACVQP-AH 408
Cdd:COG0770 339 KAALDVL-AQLPGGGRRIAVLgdmlElgEESEELhrEVG----ELAAELG-IDRLFTVGEL-----ARAIAEAAGGErAE 407
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 727166820 409 WSADLDTLVDMVVKTAQPGDHILVM-SNG-GFggihDRLLDALAKKQE 454
Cdd:COG0770 408 HFEDKEELLAALKALLRPGDVVLVKgSRGmGL----ERVVEALKEGAA 451
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
108-290 |
1.00e-12 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 66.94 E-value: 1.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 108 VAGTHGKTTTAGMATWILEACGYQ---PGFVIGGVPGNF----DVSARL-----GGSPFFVIEADEYdcAFFDKRSKFVh 175
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVigtIGTYIGKSGNTTnnaiGLPLTLaemveAGAEYAVLEVSSH--GLGEGRLSGL- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 176 YSPRTLIMNNLEFDHADIFDDLKAIQKQFHHLVRLVPGKGKIILPDNDSHLKQVMAM--GCWSEQELVGEEG--TWRAQK 251
Cdd:pfam08245 78 LKPDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKlkKAGVRVITYGIEGeaDLRAAN 157
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 727166820 252 L--TPDASHYAVFLDGEQVGEVNWALVGEHNMHNGLMAIAA 290
Cdd:pfam08245 158 IelSSDGTSFDLFTVPGGELEIEIPLLGRHNVYNALAAIAA 198
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
105-357 |
5.15e-12 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 67.46 E-value: 5.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 105 VLAVAGTHGKTTTAGMATWILEACGYQPGfVIG----GVPGNFDVS----------------ARLGGSPFFVIEAD---- 160
Cdd:PRK00139 97 LIGVTGTNGKTTTAYLLAQILRLLGEKTA-LIGtlgnGIGGELIPSglttpdaldlqrllaeLVDAGVTYAAMEVSshal 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 161 --------EYDCAFFdkrskfvhysprtlimNNLEFDHADifddlkaiqkqFHHLV--------RLVPGKGKIILPDNDS 224
Cdd:PRK00139 176 dqgrvdglKFDVAVF----------------TNLSRDHLD-----------YHGTMedylaakaRLFSELGLAAVINADD 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 225 HLKQVMAMGCWSeQELVGEEGTWRAQKLTPDASHyavfLDGEQVGEVNWALVGEHNMHNGLMAIAATRHVGVQPADACRA 304
Cdd:PRK00139 229 EVGRRLLALPDA-YAVSMAGADLRATDVEYTDSG----QTFTLVTEVESPLIGRFNVSNLLAALAALLALGVPLEDALAA 303
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 727166820 305 LGDFINARRRLELRGEANGVTVYDDFAHHPTAILATLAALRGKVGGtaRILAV 357
Cdd:PRK00139 304 LAKLQGVPGRMERVDAGQGPLVIVDYAHTPDALEKVLEALRPHAKG--RLICV 354
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
80-329 |
5.83e-11 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 64.73 E-value: 5.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 80 AVLERGIPYVSGPQWLHD----------AVLRDRW---VLAVAGTHGKTTTAGMATWILEAcgYQPGFVIGGVPGNFDvs 146
Cdd:PRK11929 567 AVVERQVADVDLPQIVVDdtraalgrlaTAWRARFslpVVAITGSNGKTTTKEMIAAILAA--WQGEDRVLATEGNFN-- 642
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 147 aRLGGSPFFVIEADE-YDCAFF----DKRSKFVHYS----PRTLIMNNLEFDHADIFDDLKAIQKQFHHLVRLVPGKGKI 217
Cdd:PRK11929 643 -NEIGVPLTLLRLRAqHRAAVFelgmNHPGEIAYLAaiaaPTVALVTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVA 721
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 218 ILPDNDSHL---------KQVMAMGCWSEQElvGEEGTWRAQKLTPDASHYAVFLD-GEQVGEVNWALVGEHNMHNGLMA 287
Cdd:PRK11929 722 VVNGDDPYTaiwaklagaRRVLRFGLQPGAD--VYAEKIAKDISVGEAGGTRCQVVtPAGSAEVYLPLIGEHNLRNALAA 799
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 727166820 288 IAATRHVGVQPADACRALGDFINARRRLELRGEANGVTVYDD 329
Cdd:PRK11929 800 IACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDD 841
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
105-346 |
7.41e-10 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 61.26 E-value: 7.41e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 105 VLAVAGTHGKTTTAGMATWILEACGYQPGfVIGGVPGNFDVS------------------ARL--GGSPFFVIEADEY-- 162
Cdd:PRK11929 114 LVAVTGTNGKTSCAQLLAQLLTRLGKPCG-SIGTLGARLDGRlipgslttpdaiilhrilARMraAGADAVAMEASSHgl 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 163 -----DCAFFDkrskfvhysprTLIMNNLEFDHADIFDDLKAIQKQFHHLVRLVPGKGKIILPDNDSHLKQVMAMGCWSE 237
Cdd:PRK11929 193 eqgrlDGLRIA-----------VAGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAAARLLAALPRGL 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 238 QELVGEEGT---WRAQKLTPDASHYAVFL-DGEQVGEVNWALVGEHNMHNGLMAIAATRHVGVQPADACRALGDFINARR 313
Cdd:PRK11929 262 KVGYSPQNAgadVQARDLRATAHGQVFTLaTPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPG 341
|
250 260 270
....*....|....*....|....*....|....*.
gi 727166820 314 RLE---LRGEANGVTVYDDFAHHPTAILATLAALRG 346
Cdd:PRK11929 342 RMErvgPTAGAQGPLVVVDYAHTPDALAKALTALRP 377
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
312-387 |
2.10e-09 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 54.27 E-value: 2.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 312 RRRLELRGEANGVTVYDDFAHHPTAILATLAALRGKVGGtaRILAVLEPrsntmkMGISKNDLAPSLGR-----ADEVFL 386
Cdd:pfam02875 2 PGRLEVVGENNGVLVIDDYAHNPDAMEAALRALRNLFPG--RLILVFGG------MGDRDAEFHALLGRlaaalADVVIL 73
|
.
gi 727166820 387 F 387
Cdd:pfam02875 74 T 74
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
105-345 |
4.36e-09 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 58.48 E-value: 4.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 105 VLAVAGTHGKTTTAGMATWILEACGYQPGFVigGVPGNFDVSARLGGSP------------------------FFVIEAD 160
Cdd:TIGR01085 87 VIGVTGTNGKTTTTSLIAQLLRLLGKKTGLI--GTIGYRLGGNDLIKNPaalttpealtlqstlaemveagaqYAVMEVS 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 161 EYdcAFFDKRSKFVHYspRTLIMNNLEFDHADI---FDDLKAIQKqfhHLVRLVPGKGKIILPDNDSH---LKQVMAMGC 234
Cdd:TIGR01085 165 SH--ALAQGRVRGVRF--DAAVFTNLSRDHLDFhgtMENYFAAKA---SLFTELGLKRFAVINLDDEYgaqFVKRLPKDI 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 235 WSEqeLVGEEGTWRAQKLTPDASHYA------VFLDGEQVGEVNWALVGEHNMHNGLMAIAATRHVG-VQPADACRALGD 307
Cdd:TIGR01085 238 TVS--AITQPADGRAQDIKITDSGYSfegqqfTFETPAGEGHLHTPLIGRFNVYNLLAALATLLHLGgIDLEDIVAALEK 315
|
250 260 270
....*....|....*....|....*....|....*...
gi 727166820 308 FINARRRLELRGEANGVTVYDDFAHHPTAILATLAALR 345
Cdd:TIGR01085 316 FRGVPGRMELVDGGQKFLVIVDYAHTPDALEKALRTLR 353
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
15-329 |
3.28e-07 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 52.28 E-value: 3.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 15 GLAmLAR---SLGHDVTGSDANVYPPMS---TLLENQGIDLIQGYDPAQLDPAPDLVIIGNAMTRGNPCVEAVLERGIPY 88
Cdd:PRK14106 17 GLA-LAKflkKLGAKVILTDEKEEDQLKealEELGELGIELVLGEYPEEFLEGVDLVVVSPGVPLDSPPVVQAHKKGIEV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 89 VSGPQ---WLHDAVlrdrwVLAVAGTHGKTTTAGMATWILEACGyQPGFVIG--GVPgNFDVSARLGGSPFFVIEAdeyd 163
Cdd:PRK14106 96 IGEVElayRFSKAP-----IVAITGTNGKTTTTTLLGEIFKNAG-RKTLVAGniGYP-LIDAVEEYGEDDIIVAEV---- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 164 caffdkrSKF-----VHYSPRTLIMNNLEFDHAD--------------IF-------------DDLKAiqkqfHHLVRLV 211
Cdd:PRK14106 165 -------SSFqletiKEFKPKVGCILNITPDHLDrhktmenyikakarIFenqrpsdytvlnyDDPRT-----RSLAKKA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 212 pgKGKIILpdndshlkqvmamgcWSEQELVgEEGTW-RAQKLtpdashYAVFLDGEQ----VGEVnwALVGEHNMHNGLM 286
Cdd:PRK14106 233 --KARVIF---------------FSRKSLL-EEGVFvKNGKI------VISLGGKEEevidIDEI--FIPGEHNLENALA 286
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 727166820 287 AIAATRHVGVQPADACRALGDFINARRRLELRGEANGVTVYDD 329
Cdd:PRK14106 287 ATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEINGVKFIND 329
|
|
| FolC |
COG0285 |
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ... |
274-432 |
6.51e-04 |
|
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Pssm-ID: 440054 [Multi-domain] Cd Length: 423 Bit Score: 42.01 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 274 ALVGEHNMHNGLMAIAATRHVGVQ----PADACRAlGdFINARR--RLELRGEanGVTVYDDFAHHPTAILATLAALRgK 347
Cdd:COG0285 248 PLLGAHQAENAALALAALEALRELglpiSEEAIRE-G-LANARWpgRLEVLSR--GPLVILDGAHNPAGARALAETLK-E 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166820 348 VGGTARILAVleprsntmkMGISKN-D----LAPSLGRADEVFLFQPHH---IPW-QVAEVADACVQPAHWSADLDTLVD 418
Cdd:COG0285 323 LFPFRKLHLV---------FGMLADkDiegmLAALAPLADEVIVTTPPSpraLDAeELAEAARELGLRVEVAPDVEEALE 393
|
170
....*....|....
gi 727166820 419 MVVKTAQPGDHILV 432
Cdd:COG0285 394 AALELADPDDLILV 407
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
105-134 |
1.85e-03 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 40.91 E-value: 1.85e-03
10 20 30
....*....|....*....|....*....|
gi 727166820 105 VLAVAGTHGKTTTAGMATWILEACGYQPGF 134
Cdd:PRK14016 482 IVAVTGTNGKTTTTRLIAHILKLSGKRVGM 511
|
|
| |
