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Conserved domains on  [gi|727166047|ref|WP_033636456|]
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MULTISPECIES: NAD(P)H-dependent glycerol-3-phosphate dehydrogenase [Serratia]

Protein Classification

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase( domain architecture ID 11478026)

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of glycerone phosphate and sn-glycerol-3-phosphate

EC:  1.1.1.94
SCOP:  4000111

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-330 0e+00

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


:

Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 553.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   6 ASMTVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQAFLPDVPFPDTLLLEADLARALAASRDVLVVVPS 85
Cdd:PRK00094   2 MKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEALADADLILVAVPS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  86 HVFGDVLRQLKPHLRPDARIVWATKGLEAETGRLLQDVAREALGEAIPLAVLSGPTFAKELAAGLPTAIALAATDAQFAD 165
Cdd:PRK00094  82 QALREVLKQLKPLLPPDAPIVWATKGIEPGTGKLLSEVLEEELPDLAPIAVLSGPSFAKEVARGLPTAVVIASTDEELAE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 166 DLQQLLHCGkSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSALGADPSTFMGMAG 245
Cdd:PRK00094 162 RVQELFHSP-YFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETFLGLAG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 246 LGDLVLTCTDNQSRNRRFGIMLGQGKGVQEAQDSIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKDAREAAL 325
Cdd:PRK00094 241 LGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYEGKDPREAVE 320

                 ....*
gi 727166047 326 SLLGR 330
Cdd:PRK00094 321 DLMGR 325
 
Name Accession Description Interval E-value
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-330 0e+00

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 553.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   6 ASMTVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQAFLPDVPFPDTLLLEADLARALAASRDVLVVVPS 85
Cdd:PRK00094   2 MKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEALADADLILVAVPS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  86 HVFGDVLRQLKPHLRPDARIVWATKGLEAETGRLLQDVAREALGEAIPLAVLSGPTFAKELAAGLPTAIALAATDAQFAD 165
Cdd:PRK00094  82 QALREVLKQLKPLLPPDAPIVWATKGIEPGTGKLLSEVLEEELPDLAPIAVLSGPSFAKEVARGLPTAVVIASTDEELAE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 166 DLQQLLHCGkSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSALGADPSTFMGMAG 245
Cdd:PRK00094 162 RVQELFHSP-YFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETFLGLAG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 246 LGDLVLTCTDNQSRNRRFGIMLGQGKGVQEAQDSIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKDAREAAL 325
Cdd:PRK00094 241 LGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYEGKDPREAVE 320

                 ....*
gi 727166047 326 SLLGR 330
Cdd:PRK00094 321 DLMGR 325
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
6-333 0e+00

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 530.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   6 ASMTVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQAFLPDVPFPDTLLLEADLARALAASRDVLVVVPS 85
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLPENLRATSDLEEALAGADLVLLAVPS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  86 HVFGDVLRQLKPHLRPDARIVWATKGLEAETGRLLQDVAREALGEAIPLAVLSGPTFAKELAAGLPTAIALAATDAQFAD 165
Cdd:COG0240   81 QALREVLEQLAPLLPPGAPVVSATKGIEPGTGLLMSEVIAEELPGALRIAVLSGPSFAEEVARGLPTAVVVASEDEEVAE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 166 DLQQLLHCgKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSALGADPSTFMGMAG 245
Cdd:COG0240  161 RLQELLST-PYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 246 LGDLVLTCTDNQSRNRRFGIMLGQGKGVQEAQDSIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKDAREAAL 325
Cdd:COG0240  240 LGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPREAVE 319

                 ....*...
gi 727166047 326 SLLGRARK 333
Cdd:COG0240  320 ALMARPLK 327
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
184-323 6.31e-81

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 242.29  E-value: 6.31e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  184 DFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSALGADPSTFMGMAGLGDLVLTCTDNQSRNRRF 263
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  264 GIMLGQGKGVQEAQDSIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKDAREA 323
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYEGKSPEEA 140
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
7-315 5.65e-62

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 201.03  E-value: 5.65e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047    7 SMTVIGAGSYGTALAITLARNG--------HTVVLW-------GHNPAQVqtLQQDRCNQAFLPDVPFPDTLLLEADLAR 71
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENAralpelfeESVRMWvfeeeieGRNLTEI--INTTHENVKYLPGIKLPANLVAVPDLVE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   72 ALAASRDVLVVVPSHVFGDVLRQLKPHLRPDARIVWATKGLE--AETGRLLQDVAREALGeaIPLAVLSGPTFAKELAAG 149
Cdd:TIGR03376  79 AAKGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEvsKDGVKLLSDIIEEELG--IPCGVLSGANLANEVAKE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  150 LPTAIALAATDAQFADD----LQQLLHcGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAE 225
Cdd:TIGR03376 157 KFSETTVGYRDPADFDVdarvLKALFH-RPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLE 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  226 MSRLGSALG--ADPSTFMGMAGLGDLVLTCTDnqSRNRRFGIMLGQ-GKGVQEAQDSI--GQVVEGYRNTKEVLALAQRH 300
Cdd:TIGR03376 236 MIKFARMFFptGEVTFTFESCGVADLITTCLG--GRNFKVGRAFAKtGKSLEELEKELlnGQSLQGVATAKEVHELLKNK 313
                         330
                  ....*....|....*..
gi 727166047  301 GV--EMPITEQIYQVLY 315
Cdd:TIGR03376 314 NKddEFPLFEAVYQILY 330
 
Name Accession Description Interval E-value
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-330 0e+00

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 553.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   6 ASMTVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQAFLPDVPFPDTLLLEADLARALAASRDVLVVVPS 85
Cdd:PRK00094   2 MKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEALADADLILVAVPS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  86 HVFGDVLRQLKPHLRPDARIVWATKGLEAETGRLLQDVAREALGEAIPLAVLSGPTFAKELAAGLPTAIALAATDAQFAD 165
Cdd:PRK00094  82 QALREVLKQLKPLLPPDAPIVWATKGIEPGTGKLLSEVLEEELPDLAPIAVLSGPSFAKEVARGLPTAVVIASTDEELAE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 166 DLQQLLHCGkSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSALGADPSTFMGMAG 245
Cdd:PRK00094 162 RVQELFHSP-YFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETFLGLAG 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 246 LGDLVLTCTDNQSRNRRFGIMLGQGKGVQEAQDSIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKDAREAAL 325
Cdd:PRK00094 241 LGDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYEGKDPREAVE 320

                 ....*
gi 727166047 326 SLLGR 330
Cdd:PRK00094 321 DLMGR 325
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
6-333 0e+00

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 530.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   6 ASMTVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQAFLPDVPFPDTLLLEADLARALAASRDVLVVVPS 85
Cdd:COG0240    1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLPENLRATSDLEEALAGADLVLLAVPS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  86 HVFGDVLRQLKPHLRPDARIVWATKGLEAETGRLLQDVAREALGEAIPLAVLSGPTFAKELAAGLPTAIALAATDAQFAD 165
Cdd:COG0240   81 QALREVLEQLAPLLPPGAPVVSATKGIEPGTGLLMSEVIAEELPGALRIAVLSGPSFAEEVARGLPTAVVVASEDEEVAE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 166 DLQQLLHCgKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSALGADPSTFMGMAG 245
Cdd:COG0240  161 RLQELLST-PYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAG 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 246 LGDLVLTCTDNQSRNRRFGIMLGQGKGVQEAQDSIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKDAREAAL 325
Cdd:COG0240  240 LGDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYEGKSPREAVE 319

                 ....*...
gi 727166047 326 SLLGRARK 333
Cdd:COG0240  320 ALMARPLK 327
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
10-314 8.83e-87

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 264.72  E-value: 8.83e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  10 VIGAGSYGTALAITLARNGHTVvLWGHNPAQVQTLQQDRCNQAFLP-DVPFPDTLLLEADLARAlAASRDVLVV-VPSHV 87
Cdd:PRK12439  12 VLGGGSWGTTVASICARRGPTL-QWVRSAETADDINDNHRNSRYLGnDVVLSDTLRATTDFAEA-ANCADVVVMgVPSHG 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  88 FGDVLRQLKPHLRPDARIVWATKGLEAETGRLLQDVAREALgEAIPLAVLSGPTFAKELAAGLPTAIALAATDAQFADDL 167
Cdd:PRK12439  90 FRGVLTELAKELRPWVPVVSLVKGLEQGTNMRMSQIIEEVL-PGHPAGILAGPNIAREVAEGYAAAAVLAMPDQHLATRL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 168 QQLLHCgKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSALGADPSTFMGMAGLG 247
Cdd:PRK12439 169 SPLFRT-RRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREMTKLGVAMGGNPETFAGLAGMG 247
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 727166047 248 DLVLTCTDNQSRNRRFGIMLGQGKGVQEAQDSIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVL 314
Cdd:PRK12439 248 DLIVTCTSQRSRNRHVGEQLGAGKPIDEIIASMNQVAEGVKAASVVMEFADEYGLNMPIAREVDAVI 314
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
2-335 2.36e-85

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 260.57  E-value: 2.36e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   2 NTVNASMTVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQAFLPDVPFPDTLLLEADLARALAASRDVLV 81
Cdd:PRK14618   1 MHHGMRVAVLGAGAWGTALAVLAASKGVPVRLWARRPEFAAALAAERENREYLPGVALPAELYPTADPEEALAGADFAVV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  82 VVPSHVFGDVLRQLKPHLRpdarIVWATKGLEAETGRLLQDVAREALGEAIPLAVLSGPTFAKELAAGLPTAIALAATDA 161
Cdd:PRK14618  81 AVPSKALRETLAGLPRALG----YVSCAKGLAPDGGRLSELARVLEFLTQARVAVLSGPNHAEEIARFLPAATVVASPEP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 162 QFADDLQQLLhCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSALGADPSTFM 241
Cdd:PRK14618 157 GLARRVQAAF-SGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVALGAEEATFY 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 242 GMAGLGDLVLTCTDNQSRNRRFGIMLGQGKGvQEAQDSIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKDAR 321
Cdd:PRK14618 236 GLSGLGDLIATATSPHSRNRAAGEAIVRGVD-REHLEAGGKVVEGLYTVKALDAWAKAHGHDLPIVEAVARVARGGWDPL 314
                        330
                 ....*....|....
gi 727166047 322 EAALSLLGRARKDE 335
Cdd:PRK14618 315 AGLRSLMGREAKEE 328
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
7-335 2.84e-83

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 254.53  E-value: 2.84e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   7 SMTVIGAGSYGTALAITLARNGHTVVLWGHNPAQvqtlqqdrcnqaflpdvpfpdtllleaDLARALAASRDVLVVVPSH 86
Cdd:PRK14619   6 TIAILGAGAWGSTLAGLASANGHRVRVWSRRSGL---------------------------SLAAVLADADVIVSAVSMK 58
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  87 VFGDVLRQLKP-HLRPDARIVWATKGLEAETGRLLQDVAREALGEAiPLAVLSGPTFAKELAAGLPTAIALAATDAQFAD 165
Cdd:PRK14619  59 GVRPVAEQVQAlNLPPETIIVTATKGLDPETTRTPSQIWQAAFPNH-PVVVLSGPNLSKEIQQGLPAATVVASRDLAAAE 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 166 DLQQLLhCGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSALGADPSTFMGMAG 245
Cdd:PRK14619 138 TVQQIF-SSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMIRVGTHLGAQTETFYGLSG 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 246 LGDLVLTCTDNQSRNRRFGIMLGQGKGVQEAQDSIGQVVEGYrNTKEVLA-LAQRHGVEMPITEQIYQVLYCHKDAREAA 324
Cdd:PRK14619 217 LGDLLATCTSPLSRNYQVGYGLAQGKSLEQILAELEGTAEGV-NTANVLVqLAQQQNIAVPITEQVYRLLQGEITPQQAL 295
                        330
                 ....*....|.
gi 727166047 325 LSLLGRARKDE 335
Cdd:PRK14619 296 EELMERDLKPE 306
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
184-323 6.31e-81

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 242.29  E-value: 6.31e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  184 DFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSALGADPSTFMGMAGLGDLVLTCTDNQSRNRRF 263
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  264 GIMLGQGKGVQEAQDSIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLYCHKDAREA 323
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYEGKSPEEA 140
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
7-164 3.63e-72

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 220.91  E-value: 3.63e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047    7 SMTVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQAFLPDVPFPDTLLLEADLARALAASRDVLVVVPSH 86
Cdd:pfam01210   1 KIAVLGAGSWGTALAKVLADNGHEVRLWGRDEELIEEINTTHENVRYLPGIKLPENLKATTDLAEALKGADIIVIVVPSQ 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727166047   87 VFGDVLRQLKPHLRPDARIVWATKGLEAETGRLLQDVAREALGEAIPLAVLSGPTFAKELAAGLPTAIALAATDAQFA 164
Cdd:pfam01210  81 ALREVLKQLKGLLKPDAILVSLSKGIEPGTLKLLSEVIEEELGIQPPIAVLSGPSHAEEVAQGLPTATVIASKDEEAA 158
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
8-315 1.71e-70

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 222.40  E-value: 1.71e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   8 MTVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQAFLPDVPFPDTLLLEADLARALAASRDVLVV-VPSH 86
Cdd:PRK14620   3 ISILGAGSFGTAIAIALSSKKISVNLWGRNHTTFESINTKRKNLKYLPTCHLPDNISVKSAIDEVLSDNATCIILaVPTQ 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  87 VFGDVLRQLK-PHLRPDARIVWATKGLEAETGRLLQDVAREALGEAiPLAVLSGPTFAKELAAGLPTAIALAATDAQFAD 165
Cdd:PRK14620  83 QLRTICQQLQdCHLKKNTPILICSKGIEKSSLKFPSEIVNEILPNN-PIAILSGPSFAKEIAEKLPCSIVLAGQNETLGS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 166 DLQQLLHcGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRLGSA--LGADPSTFMGM 243
Cdd:PRK14620 162 SLISKLS-NENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTLYSAknGSIDLNTLIGP 240
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 727166047 244 AGLGDLVLTCTDNQSRNRRFGIMLGQGKGVQEAQDSIGQVVEGYRNTKEVLALAQRHGVEMPITEQIYQVLY 315
Cdd:PRK14620 241 SCLGDLILTCTTLHSRNMSFGFKIGNGFNINQILSEGKSVIEGFSTVKPLISLAKKLNIELPICESIYNLLY 312
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
7-315 5.65e-62

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 201.03  E-value: 5.65e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047    7 SMTVIGAGSYGTALAITLARNG--------HTVVLW-------GHNPAQVqtLQQDRCNQAFLPDVPFPDTLLLEADLAR 71
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENAralpelfeESVRMWvfeeeieGRNLTEI--INTTHENVKYLPGIKLPANLVAVPDLVE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   72 ALAASRDVLVVVPSHVFGDVLRQLKPHLRPDARIVWATKGLE--AETGRLLQDVAREALGeaIPLAVLSGPTFAKELAAG 149
Cdd:TIGR03376  79 AAKGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEvsKDGVKLLSDIIEEELG--IPCGVLSGANLANEVAKE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  150 LPTAIALAATDAQFADD----LQQLLHcGKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAE 225
Cdd:TIGR03376 157 KFSETTVGYRDPADFDVdarvLKALFH-RPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLE 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  226 MSRLGSALG--ADPSTFMGMAGLGDLVLTCTDnqSRNRRFGIMLGQ-GKGVQEAQDSI--GQVVEGYRNTKEVLALAQRH 300
Cdd:TIGR03376 236 MIKFARMFFptGEVTFTFESCGVADLITTCLG--GRNFKVGRAFAKtGKSLEELEKELlnGQSLQGVATAKEVHELLKNK 313
                         330
                  ....*....|....*..
gi 727166047  301 GV--EMPITEQIYQVLY 315
Cdd:TIGR03376 314 NKddEFPLFEAVYQILY 330
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
9-322 2.25e-41

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 147.86  E-value: 2.25e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   9 TVIGAGSYGTALAITLARNGH-------TVVLW-------GHNPAQVqtLQQDRCNQAFLPDVPFPDTLLLEADLARALA 74
Cdd:PTZ00345  15 SVIGSGNWGSAISKVVGENTQrnyifhnEVRMWvleeiveGEKLSDI--INTKHENVKYLPGIKLPDNIVAVSDLKEAVE 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  75 ASrDVLV-VVPSHVFGDVLRQLKPH--LRPDARIVWATKGLEAETGR--LLQDVAREALGeaIPLAVLSGPTFAKELAAG 149
Cdd:PTZ00345  93 DA-DLLIfVIPHQFLESVLSQIKENnnLKKHARAISLTKGIIVENGKpvLCSDVIEEELG--IPCCALSGANVANDVARE 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 150 LPTAIALAATDAQFADDLQQLLHCgKSFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANARTALITRGLAEMSRL 229
Cdd:PTZ00345 170 EFSEATIGCEDKDDALIWQRLFDR-PYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLF 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 230 GSAL--GADPSTFMGMAGLGDLVLTCTDnqSRNRRFGIMLGQGKGVQ-----EAQDSIGQVVEGYRNTKEVLALAQRHGV 302
Cdd:PTZ00345 249 GKIFfpNVMDETFFESCGLADLITTCLG--GRNVRCAAEFAKRNGKKsweeiEAELLNGQKLQGTVTLKEVYEVLESHDL 326
                        330       340
                 ....*....|....*....|..
gi 727166047 303 --EMPITEQIYQVLYCHKDARE 322
Cdd:PTZ00345 327 kkEFPLFTVTYKIAFEGADPSS 348
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
244-310 5.18e-29

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 106.43  E-value: 5.18e-29
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727166047  244 AGLGDLVLTCTDNQSRNRRFGIMLgqGKGVQEAQDSIGQVVEGYRNTKEVL-ALAQRHGVEMPITEQI 310
Cdd:pfam20618   1 AGLGDLVLTCTSDLSRNRTFGLLL--GKGMTLAEAGNGQVAEGVRTAKAVAaILARAHNVEMPILEAV 66
ApbA pfam02558
Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also ...
9-142 7.87e-08

Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.


Pssm-ID: 426831 [Multi-domain]  Cd Length: 147  Bit Score: 50.69  E-value: 7.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047    9 TVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQ------TLQQDRCNQAFLPDVPFPDTLLLE-ADLaralaasrdVLV 81
Cdd:pfam02558   2 AILGAGAIGSLLGARLAKAGHDVTLILRGAELAAikknglRLTSPGGERIVPPPAVTSASESLGpIDL---------VIV 72
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 727166047   82 VVPSHVFGDVLRQLKPHLRPDARIVWATKGLEAEtgrllqDVAREALGEAiplAVLSGPTF 142
Cdd:pfam02558  73 TVKAYQTEEALEDIAPLLGPNTVVLLLQNGLGHE------EVLREAVPRE---RVLGGVTT 124
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
9-314 2.52e-07

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 51.40  E-value: 2.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   9 TVIGAGSYGTALAITLARNGHTVVLWGHnPAQVQTLQQ--------DRCNQAFLPDVPFPDTLLLEADLaralaasrdVL 80
Cdd:COG1893    4 AILGAGAIGGLLGARLARAGHDVTLVAR-GAHAEALREnglrlespDGDRTTVPVPAVTDPEELGPADL---------VL 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  81 VVVPSHVFGDVLRQLKPHLRPDARIVWATKGLEAEtgrllqDVAREALGEAiplAVLSGPTF--AKELAAGL-----PTA 153
Cdd:COG1893   74 VAVKAYDLEAAAEALAPLLGPDTVVLSLQNGLGHE------ERLAEALGAE---RVLGGVVTigATREEPGVvrhtgGGR 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 154 IALAATDAQFADDLQQLL----HCGksFRVYSNPDFIGVQLGGAVKNVIAIGAGMSDGIGFGANART----ALITRGLAE 225
Cdd:COG1893  145 LVLGELDGGPSERLEALAelleAAG--IPVEVSDDIRGALWEKLLLNAAINPLTALTGAPNGELLADpearALARALMRE 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047 226 MSRLGSALGADPSTFMGMAGLGDLVLTCTDNQSRnrrfgiMLgqgkgvqeaQDsigqvVEGYRNT------KEVLALAQR 299
Cdd:COG1893  223 VLAVARAEGVPLPEDDLEERVAAVAEATADNRSS------ML---------QD-----LEAGRPTeidainGAVVRLARR 282
                        330
                 ....*....|....*
gi 727166047 300 HGVEMPITEQIYQVL 314
Cdd:COG1893  283 LGVPTPVNEALYALL 297
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
9-106 2.85e-06

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 48.31  E-value: 2.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   9 TVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNqafLPDVPFPDTLLLEADLARalAASRDVLVV-VPSHV 87
Cdd:PRK06522   4 AILGAGAIGGLFGAALAQAGHDVTLVARRGAHLDALNENGLR---LEDGEITVPVLAADDPAE--LGPQDLVILaVKAYQ 78
                         90
                 ....*....|....*....
gi 727166047  88 FGDVLRQLKPHLRPDARIV 106
Cdd:PRK06522  79 LPAALPSLAPLLGPDTPVL 97
PRK08229 PRK08229
2-dehydropantoate 2-reductase; Provisional
5-135 5.43e-06

2-dehydropantoate 2-reductase; Provisional


Pssm-ID: 236193 [Multi-domain]  Cd Length: 341  Bit Score: 47.69  E-value: 5.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   5 NASMTVIGAGSYGTALAITLARNGHTVVLWGHnPAQVQTLQQD-------RCNQAFLPdvpfPDTLLLEADLArALAASR 77
Cdd:PRK08229   2 MARICVLGAGSIGCYLGGRLAAAGADVTLIGR-ARIGDELRAHgltltdyRGRDVRVP----PSAIAFSTDPA-ALATAD 75
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 727166047  78 DVLVVVPSHVFGDVLRQLKPHLRPDARIVWATKGLEAEtgrllqDVAREALGEAIPLA 135
Cdd:PRK08229  76 LVLVTVKSAATADAAAALAGHARPGAVVVSFQNGVRNA------DVLRAALPGATVLA 127
PRK09599 PRK09599
NADP-dependent phosphogluconate dehydrogenase;
10-102 1.39e-05

NADP-dependent phosphogluconate dehydrogenase;


Pssm-ID: 236582 [Multi-domain]  Cd Length: 301  Bit Score: 46.28  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  10 VIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQAflpdvpfpDTLlleADLARALAASRDVLVVVPS-HVF 88
Cdd:PRK09599   5 MIGLGRMGGNMARRLLRGGHEVVGYDRNPEAVEALAEEGATGA--------DSL---EELVAKLPAPRVVWLMVPAgEIT 73
                         90
                 ....*....|....
gi 727166047  89 GDVLRQLKPHLRPD 102
Cdd:PRK09599  74 DATIDELAPLLSPG 87
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
10-106 2.66e-05

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 45.19  E-value: 2.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  10 VIGAGSYGTALAITLARNGHTVV-LWGHNPAQVQTLqqdrcnQAFLPDVPF--PDTLLLEADLaralaasrdVLVVVPSH 86
Cdd:COG5495    8 IIGAGRVGTALAAALRAAGHEVVgVYSRSPASAERA------AALLGAVPAldLEELAAEADL---------VLLAVPDD 72
                         90       100
                 ....*....|....*....|..
gi 727166047  87 VFGDVLRQLK--PHLRPDARIV 106
Cdd:COG5495   73 AIAEVAAGLAaaGALRPGQLVV 94
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
9-148 2.25e-04

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 42.70  E-value: 2.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   9 TVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRcnqaflpdVPF--P--DTLLLEA----------DLARALA 74
Cdd:COG1004    4 AVIGTGYVGLVTAACLAELGHEVTCVDIDEEKIEALNAGE--------IPIyePglEELVARNvaagrlrfttDLAEAVA 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  75 ASRDVLVVVP-----------SHVFGdVLRQLKPHLRPDARIVwaTK-----GleaeTGRLLQDVAREAL-GEAIPLAVL 137
Cdd:COG1004   76 EADVVFIAVGtpsdedgsadlSYVLA-AARSIGEALKGYKVVV--TKstvpvG----TADRVRAIIAEELrGAGVDFDVV 148
                        170
                 ....*....|.
gi 727166047 138 SGPTFAKELAA 148
Cdd:COG1004  149 SNPEFLREGSA 159
PRK08655 PRK08655
prephenate dehydrogenase; Provisional
7-102 4.05e-04

prephenate dehydrogenase; Provisional


Pssm-ID: 236326 [Multi-domain]  Cd Length: 437  Bit Score: 41.90  E-value: 4.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   7 SMTVIGA-GSYGTALAITLARNGHTVVLWGHNPAQVQTLQqDRCNQAFLPDvpfPDTLLLEADLaralaasrdVLVVVPS 85
Cdd:PRK08655   2 KISIIGGtGGLGKWFARFLKEKGFEVIVTGRDPKKGKEVA-KELGVEYAND---NIDAAKDADI---------VIISVPI 68
                         90
                 ....*....|....*..
gi 727166047  86 HVFGDVLRQLKPHLRPD 102
Cdd:PRK08655  69 NVTEDVIKEVAPHVKEG 85
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
10-132 5.39e-04

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 40.54  E-value: 5.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  10 VIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLqqdrcNQAFLPDVPFpdtllleADLARALAASrDVLVV-VPSHVF 88
Cdd:COG2085    3 IIGTGNIGSALARRLAAAGHEVVIGSRDPEKAAAL-----AAELGPGARA-------GTNAEAAAAA-DVVVLaVPYEAV 69
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 727166047  89 GDVLRQLKPHLrpDARIVW-ATKGLEAETGRLLQDVAREALGEAI 132
Cdd:COG2085   70 PDVLESLGDAL--AGKIVIdATNPLPERDGFILDPPGGGSAAELV 112
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
6-42 1.05e-03

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 40.41  E-value: 1.05e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 727166047   6 ASMTVIGAGSYGTALAITLARNGHTVVLWGHNPAQVQ 42
Cdd:PRK06129   3 GSVAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAA 39
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
10-106 1.37e-03

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 39.66  E-value: 1.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047  10 VIGAGSYGTALAITLARNGHT---VVLWGHNPAQVQTLQQdRCNQAFLPDvpfpdtllleadlARALAASRDVLVV-VPS 85
Cdd:COG0345    7 FIGAGNMGSAIIKGLLKSGVPpedIIVSDRSPERLEALAE-RYGVRVTTD-------------NAEAAAQADVVVLaVKP 72
                         90       100
                 ....*....|....*....|.
gi 727166047  86 HVFGDVLRQLKPHLRPDARIV 106
Cdd:COG0345   73 QDLAEVLEELAPLLDPDKLVI 93
PRK09291 PRK09291
SDR family oxidoreductase;
10-81 1.93e-03

SDR family oxidoreductase;


Pssm-ID: 181762 [Multi-domain]  Cd Length: 257  Bit Score: 39.21  E-value: 1.93e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 727166047  10 VIGAGS-YGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQAFLPDVPFPDtLLLEADLARALAASRDVLV 81
Cdd:PRK09291   7 ITGAGSgFGREVALRLARKGHNVIAGVQIAPQVTALRAEAARRGLALRVEKLD-LTDAIDRAQAAEWDVDVLL 78
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
10-83 2.34e-03

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 39.28  E-value: 2.34e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 727166047  10 VIGAGSYGTALAITLARNGHTVVLWGHNPAQVQTLQQDRCNQ----AFLPDVpfpdtlLLEADLARAlaasrDVLVVV 83
Cdd:COG0569  100 IIGAGRVGRSLARELEEEGHDVVVIDKDPERVERLAEEDVLVivgdATDEEV------LEEAGIEDA-----DAVIAA 166
TyrA COG0287
Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is ...
9-105 4.16e-03

Prephenate dehydrogenase [Amino acid transport and metabolism]; Prephenate dehydrogenase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440056 [Multi-domain]  Cd Length: 278  Bit Score: 38.18  E-value: 4.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 727166047   9 TVIGAGSYGTALAITLARNG--HTVVLWGHNPAQVQTLQQ----DRCnqaflpdvpfpdtlllEADLARALAASrDVLVV 82
Cdd:COG0287    5 AIIGLGLIGGSLALALKRAGlaHEVVGVDRSPETLERALElgviDRA----------------ATDLEEAVADA-DLVVL 67
                         90       100
                 ....*....|....*....|....
gi 727166047  83 -VPSHVFGDVLRQLKPHLRPDARI 105
Cdd:COG0287   68 aVPVGATIEVLAELAPHLKPGAIV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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