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Conserved domains on  [gi|723588308|ref|WP_033567186|]
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MULTISPECIES: ornithine carbamoyltransferase [Salmonella]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11479748)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

EC:  2.1.3.3
Gene Ontology:  GO:0005737|GO:0016597|GO:0019546|GO:0004585|GO:0019547
PubMed:  27109103

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-334 0e+00

ornithine carbamoyltransferase; Validated


:

Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 686.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   1 MVISLKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGP 80
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  81 SGSQIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHApgKTLPELSF 160
Cdd:PRK02102  81 NDSQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHF--GPLKGLKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 161 AYLGDARNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGE 240
Cdd:PRK02102 159 AYVGDGRNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 241 PKEaWAERVSLMTPYQVNQQVVNATGNPDVKFMHCLPAFHNEHTKVGREIEMAYGLKGLEVTEEVFESAGSIVFDEAENR 320
Cdd:PRK02102 239 EDE-WEERIKLLKPYQVNMDLMKATGNPDVIFMHCLPAFHDTETKVGKEIAEKYGLKGLEVTDEVFESKYSIVFDEAENR 317

                        330
                 ....*....|....
gi 723588308 321 MHTIKAVMVATLGD 334
Cdd:PRK02102 318 MHTIKAVMVATLGD 331
 
Name Accession Description Interval E-value
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-334 0e+00

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 686.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   1 MVISLKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGP 80
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  81 SGSQIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHApgKTLPELSF 160
Cdd:PRK02102  81 NDSQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHF--GPLKGLKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 161 AYLGDARNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGE 240
Cdd:PRK02102 159 AYVGDGRNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 241 PKEaWAERVSLMTPYQVNQQVVNATGNPDVKFMHCLPAFHNEHTKVGREIEMAYGLKGLEVTEEVFESAGSIVFDEAENR 320
Cdd:PRK02102 239 EDE-WEERIKLLKPYQVNMDLMKATGNPDVIFMHCLPAFHDTETKVGKEIAEKYGLKGLEVTDEVFESKYSIVFDEAENR 317

                        330
                 ....*....|....
gi 723588308 321 MHTIKAVMVATLGD 334
Cdd:PRK02102 318 MHTIKAVMVATLGD 331
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 4-334 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 523.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   4 SLKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGS 83
Cdd:COG0078    2 NLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  84 QIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHapGKTLPELSFAYL 163
Cdd:COG0078   82 QLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREH--FGKLKGLKVAYV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 164 GDArNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGEPKE 243
Cdd:COG0078  160 GDG-NNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 244 AwAERVSLMTPYQVNQQVVNATGnPDVKFMHCLPAFHNEhtkvgreiemayglkglEVTEEVFESAGSIVFDEAENRMHT 323
Cdd:COG0078  239 A-EERIKAFKPYQVNEELMALAK-PDAIFMHCLPAHRGE-----------------EVTDEVIDGPQSVVFDEAENRLHA 299

                        330
                 ....*....|.
gi 723588308 324 IKAVMVATLGD 334
Cdd:COG0078  300 QKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 8-333 5.33e-162

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 454.12  E-value: 5.33e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308    8 RNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGSQIGH 87
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   88 KESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHAPGktLPELSFAYLGDAr 167
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGK--LKGVKVVYVGDG- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  168 NNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGEpKEAWAE 247
Cdd:TIGR00658 158 NNVCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGE-EDKKEE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  248 RVSLMTPYQVNQQVVNATgNPDVKFMHCLPAFHnehtkvgreiemayglkGLEVTEEVFESAGSIVFDEAENRMHTIKAV 327
Cdd:TIGR00658 237 RLKLFRPYQVNEELMELA-KPEVIFMHCLPAHR-----------------GEEVTDEVIEGPHSIVFDQAENRLHAQKAV 298


                  ....*.
gi 723588308  328 MVATLG 333
Cdd:TIGR00658 299 MVALLG 304
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
9-148 1.03e-71

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 218.84  E-value: 1.03e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308    9 NFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGSQIGHK 88
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   89 ESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLE 148
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 1-334 0e+00

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 686.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   1 MVISLKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGP 80
Cdd:PRK02102   1 MAFNLKGRSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  81 SGSQIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHApgKTLPELSF 160
Cdd:PRK02102  81 NDSQLGKKESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHF--GPLKGLKL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 161 AYLGDARNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGE 240
Cdd:PRK02102 159 AYVGDGRNNMANSLMVGGAKLGMDVRICAPKELWPEEELVALAREIAKETGAKITITEDPEEAVKGADVIYTDVWVSMGE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 241 PKEaWAERVSLMTPYQVNQQVVNATGNPDVKFMHCLPAFHNEHTKVGREIEMAYGLKGLEVTEEVFESAGSIVFDEAENR 320
Cdd:PRK02102 239 EDE-WEERIKLLKPYQVNMDLMKATGNPDVIFMHCLPAFHDTETKVGKEIAEKYGLKGLEVTDEVFESKYSIVFDEAENR 317

                        330
                 ....*....|....
gi 723588308 321 MHTIKAVMVATLGD 334
Cdd:PRK02102 318 MHTIKAVMVATLGD 331
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 5-332 0e+00

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 627.90  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   5 LKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGSQ 84
Cdd:PRK03515   4 FYQRHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQ 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  85 IGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHAPGKTLPELSFAYLG 164
Cdd:PRK03515  84 IGHKESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLAYAG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 165 DARNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGEPKEA 244
Cdd:PRK03515 164 DARNNMGNSLLEAAALTGLDLRLVAPKACWPEAALVTECRALAQKNGGNITLTEDIAEGVKGADFIYTDVWVSMGEPKEV 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 245 WAERVSLMTPYQVNQQVVNATGNPDVKFMHCLPAFHNEHTKVGREIEMAYGLK-GLEVTEEVFESAGSIVFDEAENRMHT 323
Cdd:PRK03515 244 WAERIALLRPYQVNSKMMQLTGNPQVKFLHCLPAFHDDQTTLGKKMAEEYGLHgGMEVTDEVFESAHSIVFDQAENRLHT 323


                 ....*....
gi 723588308 324 IKAVMVATL 332
Cdd:PRK03515 324 IKAVMVATL 332
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 4-334 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 565.14  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   4 SLKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGS 83
Cdd:PRK04284   3 NLRNRSFLTLLDFTPKEIEYLLDLSEDLKRAKYAGIEVQKLKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPTGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  84 QIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHAPgKTLPELSFAYL 163
Cdd:PRK04284  83 QMGKKESTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHLK-KPYKDIKFTYV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 164 GDARNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGEPKE 243
Cdd:PRK04284 162 GDGRNNVANALMQGAAIMGMDFHLVCPKELNPDDELLNKCKEIAAETGGKITITDDIDEGVKGSDVIYTDVWVSMGEPDE 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 244 AWAERVSLMTPYQVNQQVVNATGNPDVKFMHCLPAFHNEHTKVGREIEMAYGLKGLEVTEEVFESAGSIVFDEAENRMHT 323
Cdd:PRK04284 242 VWEERIKLLKPYQVNKEMMKKTGNPNAIFEHCLPSFHDLDTKVGKEIFEKYGLKEMEVTDEVFESKASVVFDEAENRMHT 321

                        330
                 ....*....|.
gi 723588308 324 IKAVMVATLGD 334
Cdd:PRK04284 322 IKAVMVATLGE 332
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 1-332 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 530.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   1 MVISLKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGP 80
Cdd:PRK01713   1 MAFNLKNRHLLSLVNHTEREIKYLLDLSRDLKRAKYAGTEQQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  81 SGSQIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHAPgKTLPELSF 160
Cdd:PRK01713  81 NSSQIGHKESMKDTARVLGRMYDAIEYRGFKQSIVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENCD-KPLSEISY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 161 AYLGDARNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGE 240
Cdd:PRK01713 160 VYIGDARNNMGNSLLLIGAKLGMDVRICAPKALLPEASLVEMCEKFAKESGARITVTDDIDKAVKGVDFVHTDVWVSMGE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 241 PKEAWAERVSLMTPYQVNQQVVNATGNPDVKFMHCLPAFHNEHTKVGREIEMAYG--LKGLEVTEEVFESAGSIVFDEAE 318
Cdd:PRK01713 240 PLETWGERIKLLMPYQVTPELMKRTGNPKVKFMHCLPAFHNSETKVGRQIAEKYPelANGIEVTEDVFESPMNIAFEQAE 319

                        330
                 ....*....|....
gi 723588308 319 NRMHTIKAVMVATL 332
Cdd:PRK01713 320 NRMHTIKAVMVASL 333
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 4-334 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 523.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   4 SLKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGS 83
Cdd:COG0078    2 NLKGRHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  84 QIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHapGKTLPELSFAYL 163
Cdd:COG0078   82 QLGRGESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREH--FGKLKGLKVAYV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 164 GDArNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGEPKE 243
Cdd:COG0078  160 GDG-NNVANSLLLAAAKLGMDVRIATPEGYEPDPEIVAKAKEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEE 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 244 AwAERVSLMTPYQVNQQVVNATGnPDVKFMHCLPAFHNEhtkvgreiemayglkglEVTEEVFESAGSIVFDEAENRMHT 323
Cdd:COG0078  239 A-EERIKAFKPYQVNEELMALAK-PDAIFMHCLPAHRGE-----------------EVTDEVIDGPQSVVFDEAENRLHA 299

                        330
                 ....*....|.
gi 723588308 324 IKAVMVATLGD 334
Cdd:COG0078  300 QKALLAWLLGG 310
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 4-333 0e+00

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 520.00  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   4 SLKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGS 83
Cdd:PRK12562   3 GFYKKHFLKLLDFTPAELNSLLQLAAKLKADKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  84 QIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHAPGKTLPELSFAYL 163
Cdd:PRK12562  83 QIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHLPGKAFNEMTLVYA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 164 GDARNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGEPKE 243
Cdd:PRK12562 163 GDARNNMGNSMLEAAALTGLDLRLVAPQACWPEASLVAECSALAQKHGGKITLTEDIAAGVKGADFIYTDVWVSMGEPKE 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 244 AWAERVSLMTPYQVNQQVVNATGNPDVKFMHCLPAFHNEHTKVGREIEMAYGLK-GLEVTEEVFESAGSIVFDEAENRMH 322
Cdd:PRK12562 243 KWAERIALLRGYQVNSKMMALTGNPQVKFLHCLPAFHDDQTTLGKKMAKEFGLHgGMEVTDEVFESPASIVFDQAENRMH 322

                        330
                 ....*....|.
gi 723588308 323 TIKAVMVATLG 333
Cdd:PRK12562 323 TIKAVMVATLA 333
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 8-333 5.33e-162

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 454.12  E-value: 5.33e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308    8 RNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGSQIGH 87
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   88 KESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHAPGktLPELSFAYLGDAr 167
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGK--LKGVKVVYVGDG- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  168 NNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGEpKEAWAE 247
Cdd:TIGR00658 158 NNVCNSLMLAGAKLGMDVVVATPEGYEPDADIVKKAQEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGE-EDKKEE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  248 RVSLMTPYQVNQQVVNATgNPDVKFMHCLPAFHnehtkvgreiemayglkGLEVTEEVFESAGSIVFDEAENRMHTIKAV 327
Cdd:TIGR00658 237 RLKLFRPYQVNEELMELA-KPEVIFMHCLPAHR-----------------GEEVTDEVIEGPHSIVFDQAENRLHAQKAV 298


                  ....*.
gi 723588308  328 MVATLG 333
Cdd:TIGR00658 299 MVALLG 304
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 4-332 5.85e-138

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 393.30  E-value: 5.85e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   4 SLKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGS 83
Cdd:PRK00779   1 MLMGRHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  84 QIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHapGKTLPELSFAYL 163
Cdd:PRK00779  81 QLGRGEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEH--RGSLKGLKVAWV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 164 GDArNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQcreIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGEPKE 243
Cdd:PRK00779 159 GDG-NNVANSLLLAAALLGFDLRVATPKGYEPDPEIVEK---IAKETGASIEVTHDPKEAVKGADVVYTDVWVSMGQEAE 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 244 AwAERVSLMTPYQVNQQVVnATGNPDVKFMHCLPAfHnehtkvgreiemayglKGLEVTEEVFESAGSIVFDEAENRMHT 323
Cdd:PRK00779 235 A-EERLKAFAPYQVNEELM-ALAKPDAIFMHCLPA-H----------------RGEEVTDEVIDGPQSVVWDEAENRLHA 295


                 ....*....
gi 723588308 324 IKAVMVATL 332
Cdd:PRK00779 296 QKALLAWLL 304
putr_carbamoyl TIGR04384
putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase ...
 10-334 3.25e-101

putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase (EC 2.1.3.6). There is some overlapping specificity with ornithine carbamoyltransferase (EC 2.1.3.3). The gene regularly is found next to agmatine deiminase and a carbamate kinase, suggesting a conserved catabolic agmatine deiminase pathway. [Energy metabolism, Amino acids and amines]


Pssm-ID: 275177  Cd Length: 330  Bit Score: 300.80  E-value: 3.25e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   10 FLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGSQIGHKE 89
Cdd:TIGR04384   2 FIDTNDFTKEEILDIIDLSLKIKEAIKDGYYPPLLKNKSLGMIFEQSSTRTRVSFETAMTQLGGHAQYLAPGQIQLGGHE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   90 SMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHAP-GKTLPELSFAYLGDArN 168
Cdd:TIGR04384  82 SIEDTARVLSRLVDIIMARVDRHETVVELAKYATVPVINGMSDYNHPTQELGDLFTMIEHLPaGKKLEDCKVVFVGDA-T 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  169 NMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMGEPKEAWAER 248
Cdd:TIGR04384 161 QVCVSLMFICTKMGMDFVHFGPKGYQIPEEWLAIAEANCKVSGGSVTVTDDVDEAVKGADFIYTDVWYGLYDQELSEEER 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  249 VSLMTP-YQVNQQVVnATGNPDVKFMHCLPAFHNEhtkvgreiemayglkglEVTEEVFESAGSIVFDEAENRMHTIKAV 327
Cdd:TIGR04384 241 MAIFYPkYQVNPELM-AKAGPHAKFMHCLPASRGE-----------------EVTDEVMDSPQSICFDEAENRLTAIRAL 302


                  ....*..
gi 723588308  328 MVATLGD 334
Cdd:TIGR04384 303 LVYFLYP 309
PLN02342 PLN02342
ornithine carbamoyltransferase
 5-333 2.96e-96

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 289.00  E-value: 2.96e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   5 LKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEK-QTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGS 83
Cdd:PLN02342  43 SKPKHFLHIDDFDKEEILGLLDRAKEVKALLKSGDRSfQPFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDDI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  84 QIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEH---APGKTLpelsf 160
Cdd:PLN02342 123 QLGKREETRDIARVLSRYNDIIMARVFAHQDVLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEHigrLEGTKV----- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 161 AYLGDArNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREiASVTgaRITLTESVEDGVHGVDFLYTDVWVSMGE 240
Cdd:PLN02342 198 VYVGDG-NNIVHSWLLLAAVLPFHFVCACPKGYEPDAKTVEKARA-AGIS--KIEITNDPAEAVKGADVVYTDVWASMGQ 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 241 pKEAWAERVSLMTPYQVNQQVVNATGnPDVKFMHCLPAFhnehtkvgreiemayglKGLEVTEEVFESAGSIVFDEAENR 320
Cdd:PLN02342 274 -KEEAEKRKKAFQGFQVNEALMKLAG-PQAYFMHCLPAE-----------------RGVEVTDGVMEAPNSIVFPQAENR 334

                        330
                 ....*....|...
gi 723588308 321 MHTIKAVMVATLG 333
Cdd:PLN02342 335 MHAQNAIMLHQLG 347
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 8-333 1.24e-87

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 265.40  E-value: 1.24e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   8 RNFLKLLDYTPAEIQHLIDLAIELKAAKKAgcEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGSQIGH 87
Cdd:PRK14805   2 KHLLSIKELTQQQLLDLLALAKTIKANPAE--YRQALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGALGK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  88 KESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHAPgkTLPELSFAYLGDAr 167
Cdd:PRK14805  80 RESVADFAANLSCWADAIVARVFSHSTIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQFG--DVSKVKLAYVGDG- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 168 NNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDgVHGVDFLYTDVWVSMGEPKEAWAE 247
Cdd:PRK14805 157 NNVTHSLMYGAAILGATMTVICPPGHFPDGQIVAEAQELAAKSGGKLVLTSDIEA-IEGHDAIYTDTWISMGDDTPLAEI 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 248 RVSLMtPYQVNQQVVNATGNPdvKFMHCLPAFhnehtkvgreiemayglKGLEVTEEVFESAGSIVFDEAENRMHTIKAV 327
Cdd:PRK14805 236 KAKFA-PYQVNKALMEKAGAT--FVMHCQPAH-----------------RGVEITSEVMDGEGSLILQQAENRMHAQNAV 295


                 ....*.
gi 723588308 328 MVATLG 333
Cdd:PRK14805 296 LVTLLS 301
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
9-148 1.03e-71

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 218.84  E-value: 1.03e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308    9 NFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGSQIGHK 88
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   89 ESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLE 148
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
160-331 2.86e-66

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 205.54  E-value: 2.86e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  160 FAYLGDARNNMGNSLMVGAAKMGMDIRLIAPKSFWPDAALVAQCREIASVTGARITLTESVEDGVHGVDFLYTDVWVSMG 239
Cdd:pfam00185   2 IAYVGDGHNNVAHSLIIAAAKLGMDVRLATPKGYPPDPEVLDKAKKIAEKSGGSIEITDDPAEAVKGADVVYTDVWQSMG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  240 EPKEaWAERVSLMTPYQVNQQVVNATGnPDVKFMHCLPAFHNEhtkvgreiemayglkglEVTEEVFESAGSIVFDEAEN 319
Cdd:pfam00185  82 QEKE-REERLKAFKPYQVNEELMKLAK-KDAIFMHCLPAHRGE-----------------EVTDDVFDGPRSVVFDQAEN 142

                         170
                  ....*....|..
gi 723588308  320 RMHTIKAVMVAT 331
Cdd:pfam00185 143 RLHAQKALLALL 154
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 15-332 2.73e-43

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 151.33  E-value: 2.73e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  15 DYTPAEIQHLIDLAIELKAAK--KAGcekqTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGSQIgHKESMK 92
Cdd:PRK14804  14 DWSDSEILDLLDFAVHVKKNRvnYAG----HMSGRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMASNF-QLSDID 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  93 DTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNGLTDEFHPTQILADLMTMLEHAPGKTLPELSFAYLGdARNNMGN 172
Cdd:PRK14804  89 LEARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMFHPCQSLADIMTIALDSPEIPLNQKQLTYIG-VHNNVVN 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 173 SLMVGAAKMGMDIRLIAPksFWPDAALVAQCREIASVTGArITLTESVEDGVHGVDFLYTDVWVSM---GEPKEA--WAE 247
Cdd:PRK14804 168 SLIGITAALGIHLTLVTP--IAAKENIHAQTVERAKKKGT-LSWEMNLHKAVSHADYVYTDTWLDMeffNDPSYAdkKKQ 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 248 RVSLMTPYQVNQQVVNATgnpDVKFMHCLPaFHnehtkvgreiemayglKGLEVTEEVFESAGSIVFDEAENRMHTIKAV 327
Cdd:PRK14804 245 RMELMMPYQINSSLMEKT---NAKVMHDMP-IH----------------AGYEITREVVLSDRSIIFQQAENRLDAQKAV 304


                 ....*
gi 723588308 328 MVATL 332
Cdd:PRK14804 305 ILKLL 309
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 8-328 5.30e-39

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 140.65  E-value: 5.30e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   8 RNFLKLLDYTPAEIQHLIDLAIELKAAKKAgcekQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGS--QI 85
Cdd:PRK04523   4 KHFLNTQDWSRAELDALLTQAAAFKRNKLG----SALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLQPGKDawPI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  86 GHK----------ESMKDTAHVLGRMYDGIEYRGFGQH----------IVEELGEYAGVPVWNGLTDEfHPTQILADLMT 145
Cdd:PRK04523  80 EFElgavmdgeteEHIREVARVLSRYVDLIGVRAFPKFvdwskdrqdqVLNSFAKYSTVPVINMETIT-HPCQELAHALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 146 MLEH----APGKTLPeLSFAY----LGDArnnMGNSLMVGAAKMGMDIRLIAPK-SFWPDAALVAQCREIASVTGARITL 216
Cdd:PRK04523 159 LQEHfgttLRGKKYV-LTWTYhpkpLNTA---VANSALLIATRLGMDVTLLCPTpDYILDERYMDWAEQNAAESGGSLTV 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 217 TESVEDGVHGVDFLYTDVWvsmGEPK--EAWAERVSLMTPYQ---VNQQVVNATGNpdVKFMHCLPAFHNehtkvgreie 291
Cdd:PRK04523 235 SHDIDSAYAGADVVYAKSW---GALPffGNWEPEKPIRDQYQhfiVDERKMALTNN--GVFSHCLPLRRN---------- 299

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 723588308 292 mayglkgLEVTEEVFESAGSIVFDEAENRMHTIKAVM 328
Cdd:PRK04523 300 -------VKVTDAVMDSPNCIAIDEAENRLHVQKAIM 329
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
4-328 6.40e-31

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 118.25  E-value: 6.40e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   4 SLKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEK-QTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSG 82
Cdd:PRK00856   2 PLKMKHLLSIEDLSREEIELLLDTAEEFKEVLRREVKKvPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAST 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  83 SQIGHKESMKDTAHVLGRMY-DGIEYRgfgqH----IVEELGEYAGVPVWNGlTD---EfHPTQILADLMTMLEHapGKT 154
Cdd:PRK00856  82 SSVSKGETLADTIRTLSAMGaDAIVIR----HpqsgAARLLAESSDVPVINA-GDgshQ-HPTQALLDLLTIREE--FGR 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 155 LPELSFAYLGD------ARnnmgnSLMVGAAKMGMDIRLIAPKSFWPDAAlvaqcreiasvtgARITLTESVEDGVHGVD 228
Cdd:PRK00856 154 LEGLKVAIVGDikhsrvAR-----SNIQALTRLGAEVRLIAPPTLLPEGM-------------PEYGVHTDLDEVIEDAD 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 229 FLYTdvw--vsMGEPKEAWAERVSLMtpYQVNQQVVNATgNPDVKFMHCLPafhnehtkVGREIEMAYglkglevteEVF 306
Cdd:PRK00856 216 VVMMlrvqkerMDGGLLPSYEEYKRS--YGLTAERLALA-KPDAIVMHPGP--------VNRGVEIAS---------DVA 275

                        330       340
                 ....*....|....*....|....*.
gi 723588308 307 ESAGSIVFDEAEN----RMhtikAVM 328
Cdd:PRK00856 276 DGPQSVIFEQVTNgvavRM----AVL 297
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 5-330 5.11e-16

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 78.24  E-value: 5.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308   5 LKNRNFLKLLDYTPAEIQHLIDLAIELKAAKKAGCEKQTL-IGKNIALiFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGS 83
Cdd:PRK07200  18 MHEKDFLLTWEKTPDELKAVLDVADALRALREENISTKVFnSGLGISV-FRDNSTRTRFSYASACNLLGLEVQDLDEGKS 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  84 QIGHKESMKDTAHVLGRMYDGIEYR-----GFGQHIVEELGEY------AGV----PVWNGL-TDEFHPTQILADLMTML 147
Cdd:PRK07200  97 QIAHGETVRETANMISFMADVIGIRddmyiGKGNAYMREVGAAvddgykQGVlpqrPTLVNLqCDIDHPTQSMADLLHLI 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 148 EH------APGKTLPeLSFAYlgdaRNNMGNSLMV--GAA----KMGMDIRLIAPKSF--WPDAALVAqcREIASVTGAR 213
Cdd:PRK07200 177 EHfgglenLKGKKIA-MTWAY----SPSYGKPLSVpqGIIglmtRFGMDVTLAHPEGYdlMPEVVEVA--KKNAKASGGS 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 214 ITLTESVEDGVHGVDFLYTDVWVsmgePKEAWAERVSLMTP----------------------YQVNQQVVNATGNPDVK 271
Cdd:PRK07200 250 FRQVNSMEEAFKDADIVYPKSWA----PYKVMEERTELYRAgdhegikalekellaqnaqhkdWHCTEEMMKLTKDGKAL 325

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 723588308 272 FMHCLPAfhnEHTKVGREiemayglKGlEVTEEVFESAGSIVFDEAENRMHTIKAVMVA 330
Cdd:PRK07200 326 YMHCLPA---DISGVSCK-------EG-EVTESVFDRYRIALYKEASWKPYIIAAMIFL 373
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 51-277 9.31e-16

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 77.60  E-value: 9.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  51 LIFEkTSTRTRCAFEvAAFDQ--GAQVTYLGPSGSQIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWN 128
Cdd:PRK11891 132 LFFE-ASTRTRVSFG-AAFCRlgGSVCDTTGFTFSSMAKGESIYDTSRVMSGYVDALVIRHPEQGSVAEFARATNLPVIN 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 129 GLTDEF-HPTQILADLMTMLEHAP--GKTLPELSFAYLGDARNNMG-NSLM-VGAAKMGMDIRLIAPksfwPDAALVAQC 203
Cdd:PRK11891 210 GGDGPGeHPSQALLDLYTIQREFSrlGKIVDGAHIALVGDLKYGRTvHSLVkLLALYRGLKFTLVSP----PTLEMPAYI 285

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 723588308 204 REIASVTGARITLTESVEDGVHGVDFLY-TDVwvsmgePKEAWA-ERVSLMTP-YQVNQQVVNATGNPDVKFMHCLP 277
Cdd:PRK11891 286 VEQISRNGHVIEQTDDLAAGLRGADVVYaTRI------QKERFAdESFEGYTPdFQINQALVDAVCKPDTLIMHPLP 356
pyrB PRK13814
aspartate carbamoyltransferase;
42-196 1.32e-14

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 73.21  E-value: 1.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  42 QTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSGSQIGHKESMKDTAHVLGRMydGIEY---RGFGQHIVEEL 118
Cdd:PRK13814  41 ETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISAISKGETLFDTIKTLEAM--GVYFfivRHSENETPEQI 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 119 GEY--AGVPVWNGLTDEFHPTQILADLMTMLEHAPGKTlpELSFAYLGDARNN-MGNSLMVGAAKMGM-DIRLIAPKSFW 194
Cdd:PRK13814 119 AKQlsSGVVINAGDGNHQHPSQALIDLMTIKQHKPHWN--KLCVTIIGDIRHSrVANSLMDGLVTMGVpEIRLVGPSSLL 196


                 ..
gi 723588308 195 PD 196
Cdd:PRK13814 197 PD 198
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 51-277 2.10e-14

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 72.84  E-value: 2.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  51 LIFEKtSTRTRCAFEVAAFDQGAQVT-YLGPSGSQIGHKESMKDTAHVLGRMYDGIEYRGFGQHIVEELGEYAGVPVWNG 129
Cdd:PRK08192  50 LFFEP-STRTRVSFGCAFNLLGGHVReTTGMASSSLSKGESLYDTARVLSTYSDVIAMRHPDAGSVKEFAEGSRVPVING 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 130 --LTDEfHPTQILADLMTM---LEHApGKTLPELSFAYLGDARNnmGNSLMVGAAKMGM--DIR--LIAPKSFWPDAALV 200
Cdd:PRK08192 129 gdGSNE-HPTQALLDLFTIqkeLAHA-GRGIDGMHIAMVGDLKF--GRTVHSLSRLLCMykNVSftLVSPKELAMPDYVI 204

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 723588308 201 AQCREiasvTGARITLTESVEDGVHGVDFLY-TDVWVS-MGEPKEAWAERvslmTPYQVNQQVVNATGNPDVKFMHCLP 277
Cdd:PRK08192 205 SDIEN----AGHKITITDQLEGNLDKADILYlTRIQEErFPSQEEANKYR----GKFRLNQSIYTQHCKSNTVIMHPLP 275
PLN02527 PLN02527
aspartate carbamoyltransferase
 24-334 4.23e-07

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 50.90  E-value: 4.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308  24 LIDLAIELKAAKKAGCEKQTLIGKNIALIFEKTSTRTRCAFEVAAFDQGAQVTYLGPSG--SQIGHKESMKDTAHVLGRM 101
Cdd:PLN02527  17 LFEVAREMEKVERGSPGSQMLKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTENAGefSSAAKGETLEDTIRTVEGY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 102 YDGIEYRGFGQHIVEELGEYAGVPVWN-GLTDEFHPTQILADLMTmLEHAPGKtLPELSFAYLGDARNNMG-NSLMVGAA 179
Cdd:PLN02527  97 SDIIVLRHFESGAARRAAATAEIPVINaGDGPGQHPTQALLDVYT-IQREIGR-LDGIKVGLVGDLANGRTvRSLAYLLA 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 180 KM-GMDIRLIAPKSF-WPDaalvaQCREIASVTGARITLTESVEDGVHGVDFLY-TDVwvsmgePKEAWAERVSLMTP-- 254
Cdd:PLN02527 175 KYeDVKIYFVAPDVVkMKD-----DIKDYLTSKGVEWEESSDLMEVASKCDVLYqTRI------QRERFGERIDLYEAar 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723588308 255 --YQVNQQVVNATgNPDVKFMHCLPAFHnehtkvgreiemayglkglEVTEEVFESAGSIVFDEAENRMHTIKAVMVATL 332
Cdd:PLN02527 244 gkYIVDKKVMDVL-PKHAVVMHPLPRLD-------------------EITTDVDSDPRAAYFRQAKNGLFIRMALLKLLL 303


                 ..
gi 723588308 333 GD 334
Cdd:PLN02527 304 GG 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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