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Conserved domains on  [gi|723050030|ref|WP_033547277|]
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MULTISPECIES: ATP-dependent endonuclease [Enterobacteriaceae]

Protein Classification

ATP-dependent nuclease( domain architecture ID 11466458)

ATP-dependent nuclease is an OLD (overcoming lysogenization defect) family ATP-dependent nuclease which may have DNAse as well as RNAse activity; similar to Bacillus cereus endonuclease GajA and bacteriophage P2 OLD nuclease, which displays exonuclease activity

CATH:  3.40.50.300
EC:  3.1.-.-
Gene Ontology:  GO:0004519|GO:0004527|GO:0016887|GO:0005524|GO:0046872
PubMed:  18466635|32009148|31400118|37840731

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YbjD COG3593
Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM ...
 25-462 1.25e-22

Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains [Replication, recombination and repair];


:

Pssm-ID: 442812 [Multi-domain]  Cd Length: 359  Bit Score: 99.69  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  25 FIQHIRFPYFKNIEqNARIDFQFPITALVGKNGTNKSSVIKAL---FGCPHGKNITRywfttetDEFpdlkladgsslkp 101
Cdd:COG3593    2 KLEKIKIKNFRSIK-DLSIELSDDLTVLVGENNSGKSSILEALrllLGPSSSRKFDE-------EDF------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 102 ryiygYKNADGRLVEIlqarinatkktidywetsrpsvgdnmeSISddlgansnatrwkkikkglvfLDFRSEISAFdrc 181
Cdd:COG3593   61 -----YLGDDPDLPEI---------------------------EIE---------------------LTFGSLLSRL--- 84

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 182 myhSDFKLRKKKSGVLITKQDYIRSKSKYIKKAFDEKLSNLrlwgAETIVKNITLapelveHVSFILGKKYKVIKFLEHR 261
Cdd:COG3593   85 ---LRLLLKEEDKEELEEALEELNEELKEALKALNELLSEY----LKELLDGLDL------ELELSLDELEDLLKSLSLR 151

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 262 LFgtrggtallstDKLNYTEAFAGSGE-----FAIVSLILNIYSAKPNSLILLDEPEVSLHPGAQKRMMDVLYSIVEqKK 336
Cdd:COG3593  152 IE-----------DGKELPLDRLGSGFqrlilLALLSALAELKRAPANPILLIEEPEAHLHPQAQRRLLKLLKELSE-KP 219

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 337 HQVVISTHSPVIVNTLPKDAIKLFVFDEESETAKIVQNIAPDEAFI---ELGHDIN-----KKTIIVEDKLAKAIIDKAI 408
Cdd:COG3593  220 NQVIITTHSPHLLSEVPLENIRRLRRDSGGTTSTKLIDLDDEDLRKllrYLGVTRSellfaRKVILVEGDTEVILLPALA 299

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 723050030 409 KNDERLSLSFSVSYIPGGSETILsKHLPSYAVVERNDILFLLDGDKNKKIKPVR 462
Cdd:COG3593  300 RKLGKDLDEEGISIIPVGGKSNL-KPLAKLLKALGIPVAVLTDGDEAGKAETIE 352
 
Name Accession Description Interval E-value
YbjD COG3593
Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM ...
 25-462 1.25e-22

Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains [Replication, recombination and repair];


Pssm-ID: 442812 [Multi-domain]  Cd Length: 359  Bit Score: 99.69  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  25 FIQHIRFPYFKNIEqNARIDFQFPITALVGKNGTNKSSVIKAL---FGCPHGKNITRywfttetDEFpdlkladgsslkp 101
Cdd:COG3593    2 KLEKIKIKNFRSIK-DLSIELSDDLTVLVGENNSGKSSILEALrllLGPSSSRKFDE-------EDF------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 102 ryiygYKNADGRLVEIlqarinatkktidywetsrpsvgdnmeSISddlgansnatrwkkikkglvfLDFRSEISAFdrc 181
Cdd:COG3593   61 -----YLGDDPDLPEI---------------------------EIE---------------------LTFGSLLSRL--- 84

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 182 myhSDFKLRKKKSGVLITKQDYIRSKSKYIKKAFDEKLSNLrlwgAETIVKNITLapelveHVSFILGKKYKVIKFLEHR 261
Cdd:COG3593   85 ---LRLLLKEEDKEELEEALEELNEELKEALKALNELLSEY----LKELLDGLDL------ELELSLDELEDLLKSLSLR 151

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 262 LFgtrggtallstDKLNYTEAFAGSGE-----FAIVSLILNIYSAKPNSLILLDEPEVSLHPGAQKRMMDVLYSIVEqKK 336
Cdd:COG3593  152 IE-----------DGKELPLDRLGSGFqrlilLALLSALAELKRAPANPILLIEEPEAHLHPQAQRRLLKLLKELSE-KP 219

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 337 HQVVISTHSPVIVNTLPKDAIKLFVFDEESETAKIVQNIAPDEAFI---ELGHDIN-----KKTIIVEDKLAKAIIDKAI 408
Cdd:COG3593  220 NQVIITTHSPHLLSEVPLENIRRLRRDSGGTTSTKLIDLDDEDLRKllrYLGVTRSellfaRKVILVEGDTEVILLPALA 299

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 723050030 409 KNDERLSLSFSVSYIPGGSETILsKHLPSYAVVERNDILFLLDGDKNKKIKPVR 462
Cdd:COG3593  300 RKLGKDLDEEGISIIPVGGKSNL-KPLAKLLKALGIPVAVLTDGDEAGKAETIE 352
AAA_21 pfam13304
AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being ...
 49-350 4.42e-17

AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.


Pssm-ID: 433102 [Multi-domain]  Cd Length: 303  Bit Score: 82.44  E-value: 4.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030   49 ITALVGKNGTNKSSVIKAL---------------FGCPHGKN--ITRYWFTTETDEFPDLKLADGSSLKPRYIYGYKNAD 111
Cdd:pfam13304   1 INVLIGPNGSGKSNLLEALrfladfdalvigltdERSRNGGIggIPSLLNGIDPKEPIEFEISEFLEDGVRYRYGLDLER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  112 GRLVEILQARINATKKTIDY-------WETSRPSVGDNMESISDDLGANSNATRWKKIKKGLVFLDFRSEISAFdrcmYH 184
Cdd:pfam13304  81 EDVEEKLSSKPTLLEKRLLLredseerEPKFPPEAEELRLGLDVEERIELSLSELSDLISGLLLLSIISPLSFL----LL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  185 SDFKLRKKKSGVLITKQDYIR--SKSKYIKKAFDEKLSNLRLWGAETIVKNITLAPELVEHVSFILGKKYKVIKFLEHRL 262
Cdd:pfam13304 157 LDEGLLLEDWAVLDLAADLALfpDLKELLQRLVRGLKLADLNLSDLGEGIEKSLLVDDRLRERGLILLENGGGGELPAFE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  263 FGtrggtallstdklnyteafagSGEFAIVSLILNIYSA-KPNSLILLDEPEVSLHPGAQKRMMDVLySIVEQKKHQVVI 341
Cdd:pfam13304 237 LS---------------------DGTKRLLALLAALLSAlPKGGLLLIDEPESGLHPKLLRRLLELL-KELSRNGAQLIL 294


                  ....*....
gi 723050030  342 STHSPVIVN 350
Cdd:pfam13304 295 TTHSPLLLD 303
ABC_UvrA cd03238
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ...
 287-351 2.55e-04

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.


Pssm-ID: 213205 [Multi-domain]  Cd Length: 176  Bit Score: 42.31  E-value: 2.55e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 723050030 287 GEFAIVSLILNIYSAKPNSLILLDEPEVSLHPGAQKRMMDVLYSIVeQKKHQVVISTHSPVIVNT 351
Cdd:cd03238   91 GELQRVKLASELFSEPPGTLFILDEPSTGLHQQDINQLLEVIKGLI-DLGNTVILIEHNLDVLSS 154
retron_eff_Eco8 NF038234
retron Eco8 family effector endonuclease; This ATPase, found as the effector protein partner ...
 306-360 4.61e-03

retron Eco8 family effector endonuclease; This ATPase, found as the effector protein partner next to a reverse transcriptase in Eco8 type retron systems, is a predicted OLD family endonuclease.


Pssm-ID: 468422 [Multi-domain]  Cd Length: 679  Bit Score: 40.01  E-value: 4.61e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 723050030 306 LILLDEPEVSLHPGAQKRMMDVLYSIVEQKKH-------QVVISTHSPVIVntlpKDAIKLF 360
Cdd:NF038234 275 FIFIDEPELGLHPKLNEQLINEIYESYSFKKKdnktpypKIILATHSPRII----KNIIKLF 332
cbiO PRK13634
cobalt transporter ATP-binding subunit; Provisional
 307-345 7.81e-03

cobalt transporter ATP-binding subunit; Provisional


Pssm-ID: 237454 [Multi-domain]  Cd Length: 290  Bit Score: 38.85  E-value: 7.81e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 723050030 307 ILLDEPEVSLHPGAQKRMMDVLYSIVEQKKHQVVISTHS 345
Cdd:PRK13634 167 LVLDEPTAGLDPKGRKEMMEMFYKLHKEKGLTTVLVTHS 205
 
Name Accession Description Interval E-value
YbjD COG3593
Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM ...
 25-462 1.25e-22

Predicted ATP-dependent endonuclease of the OLD family, contains P-loop ATPase and TOPRIM domains [Replication, recombination and repair];


Pssm-ID: 442812 [Multi-domain]  Cd Length: 359  Bit Score: 99.69  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  25 FIQHIRFPYFKNIEqNARIDFQFPITALVGKNGTNKSSVIKAL---FGCPHGKNITRywfttetDEFpdlkladgsslkp 101
Cdd:COG3593    2 KLEKIKIKNFRSIK-DLSIELSDDLTVLVGENNSGKSSILEALrllLGPSSSRKFDE-------EDF------------- 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 102 ryiygYKNADGRLVEIlqarinatkktidywetsrpsvgdnmeSISddlgansnatrwkkikkglvfLDFRSEISAFdrc 181
Cdd:COG3593   61 -----YLGDDPDLPEI---------------------------EIE---------------------LTFGSLLSRL--- 84

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 182 myhSDFKLRKKKSGVLITKQDYIRSKSKYIKKAFDEKLSNLrlwgAETIVKNITLapelveHVSFILGKKYKVIKFLEHR 261
Cdd:COG3593   85 ---LRLLLKEEDKEELEEALEELNEELKEALKALNELLSEY----LKELLDGLDL------ELELSLDELEDLLKSLSLR 151

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 262 LFgtrggtallstDKLNYTEAFAGSGE-----FAIVSLILNIYSAKPNSLILLDEPEVSLHPGAQKRMMDVLYSIVEqKK 336
Cdd:COG3593  152 IE-----------DGKELPLDRLGSGFqrlilLALLSALAELKRAPANPILLIEEPEAHLHPQAQRRLLKLLKELSE-KP 219

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 337 HQVVISTHSPVIVNTLPKDAIKLFVFDEESETAKIVQNIAPDEAFI---ELGHDIN-----KKTIIVEDKLAKAIIDKAI 408
Cdd:COG3593  220 NQVIITTHSPHLLSEVPLENIRRLRRDSGGTTSTKLIDLDDEDLRKllrYLGVTRSellfaRKVILVEGDTEVILLPALA 299

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 723050030 409 KNDERLSLSFSVSYIPGGSETILsKHLPSYAVVERNDILFLLDGDKNKKIKPVR 462
Cdd:COG3593  300 RKLGKDLDEEGISIIPVGGKSNL-KPLAKLLKALGIPVAVLTDGDEAGKAETIE 352
COG4637 COG4637
Predicted ATPase [General function prediction only];
26-368 6.03e-18

Predicted ATPase [General function prediction only];


Pssm-ID: 443675 [Multi-domain]  Cd Length: 371  Bit Score: 85.75  E-value: 6.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  26 IQHIRFPYFKNIEqNARIDFQfPITALVGKNGTNKSSVIKAL-F--GCPHGkNITRY-----------WFTTETDEFP-- 89
Cdd:COG4637    2 ITRIRIKNFKSLR-DLELPLG-PLTVLIGANGSGKSNLLDALrFlsDAARG-GLQDAlarrggleellWRGPRTITEPir 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  90 -DLKLADGSSLKPRYIY--GYKNADGRLV---EILQARINATKKTIDYWETSRPSVGDNMESISDDlgaNSNATRWKKIK 163
Cdd:COG4637   79 lELEFAEEDERDLRYELelGLPEPGGRPEvkeERLWLKRGSGGRPFLDFRPKGRAVGGEPERLDSP---ESLLSQLGDPE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 164 KGLVFLDFRSEISAFdRCMYHSDFKLRKkksGVLITKQDYIRSKS-------KYIKKAFDEKLsnlrlwgaETIVKNITL 236
Cdd:COG4637  156 RFPELRALREALRSW-RFYDFHPAPLRQ---PQPAGRTPVLAPDGsnlaavlATLRETHPERF--------ERILEALRD 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 237 APELVEHVSFILGKKYKVIKFLEHRLFGTRGGTALLSTDKLNYteafagsgeFAIVSLILniySAKPNSLILLDEPEVSL 316
Cdd:COG4637  224 AFPGFEDIEVEPDEDGRVLLEFREKGLDRPFPARELSDGTLRF---------LALLAALL---SPRPPPLLCIEEPENGL 291

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 723050030 317 HPGAQKRMMDVLYSIVEqkKHQVVISTHSPVIVNTLPKDAIKLFVFDEESET 368
Cdd:COG4637  292 HPDLLPALAELLREASE--RTQVIVTTHSPALLDALEPEEVLVLEREDDGET 341
AAA_21 pfam13304
AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being ...
 49-350 4.42e-17

AAA domain, putative AbiEii toxin, Type IV TA system; Several members are annotated as being of the abortive phage resistance system, in which case the family would be acting as the toxin for a type IV toxin-antitoxin resistance system.


Pssm-ID: 433102 [Multi-domain]  Cd Length: 303  Bit Score: 82.44  E-value: 4.42e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030   49 ITALVGKNGTNKSSVIKAL---------------FGCPHGKN--ITRYWFTTETDEFPDLKLADGSSLKPRYIYGYKNAD 111
Cdd:pfam13304   1 INVLIGPNGSGKSNLLEALrfladfdalvigltdERSRNGGIggIPSLLNGIDPKEPIEFEISEFLEDGVRYRYGLDLER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  112 GRLVEILQARINATKKTIDY-------WETSRPSVGDNMESISDDLGANSNATRWKKIKKGLVFLDFRSEISAFdrcmYH 184
Cdd:pfam13304  81 EDVEEKLSSKPTLLEKRLLLredseerEPKFPPEAEELRLGLDVEERIELSLSELSDLISGLLLLSIISPLSFL----LL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  185 SDFKLRKKKSGVLITKQDYIR--SKSKYIKKAFDEKLSNLRLWGAETIVKNITLAPELVEHVSFILGKKYKVIKFLEHRL 262
Cdd:pfam13304 157 LDEGLLLEDWAVLDLAADLALfpDLKELLQRLVRGLKLADLNLSDLGEGIEKSLLVDDRLRERGLILLENGGGGELPAFE 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  263 FGtrggtallstdklnyteafagSGEFAIVSLILNIYSA-KPNSLILLDEPEVSLHPGAQKRMMDVLySIVEQKKHQVVI 341
Cdd:pfam13304 237 LS---------------------DGTKRLLALLAALLSAlPKGGLLLIDEPESGLHPKLLRRLLELL-KELSRNGAQLIL 294


                  ....*....
gi 723050030  342 STHSPVIVN 350
Cdd:pfam13304 295 TTHSPLLLD 303
COG3950 COG3950
Predicted ATP-binding protein involved in virulence [General function prediction only];
25-366 6.99e-14

Predicted ATP-binding protein involved in virulence [General function prediction only];


Pssm-ID: 443150 [Multi-domain]  Cd Length: 276  Bit Score: 72.34  E-value: 6.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  25 FIQHIRFPYFKNIEqNARIDFQFP--ITALVGKNGTNKSSVIKALFGCphgknITRYWFTTETDEFPDLKLADGSSLKPR 102
Cdd:COG3950    2 RIKSLTIENFRGFE-DLEIDFDNPprLTVLVGENGSGKTTLLEAIALA-----LSGLLSRLDDVKFRKLLIRNGEFGDSA 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 103 YIYGYKNAdGRLVeiLQARINATKKTidywetsRPSVGDNMESISDDLGANSNATRWKKikkglVFLDFRSEISAFDRCM 182
Cdd:COG3950   76 KLILYYGT-SRLL--LDGPLKKLERL-------KEEYFSRLDGYDSLLDEDSNLREFLE-----WLREYLEDLENKLSDE 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 183 YHSDFKLrkkksgvlitkqdyirskskyIKKAFDEKLSNlrlwgaetiVKNITLAPELVEHVsfILGKKYKVIKFLEhrl 262
Cdd:COG3950  141 LDEKLEA---------------------VREALNKLLPD---------FKDIRIDRDPGRLV--ILDKNGEELPLNQ--- 185

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 263 fgtrggtalLStdklnyteafagSGE---FAIVS-LILNIYSAKP--------NSLILLDEPEVSLHPGAQKRMMDVLYS 330
Cdd:COG3950  186 ---------LS------------DGErslLALVGdLARRLAELNPalenplegEGIVLIDEIDLHLHPKWQRRILPDLRK 244

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 723050030 331 IVeqKKHQVVISTHSPVIVNTLPKDAIklFVFDEES 366
Cdd:COG3950  245 IF--PNIQFIVTTHSPLILSSLEDEEV--IVLERDE 276
COG4938 COG4938
Predicted ATPase [General function prediction only];
246-398 9.91e-14

Predicted ATPase [General function prediction only];


Pssm-ID: 443965 [Multi-domain]  Cd Length: 277  Bit Score: 71.92  E-value: 9.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 246 FILGK-KYKVIKFLEHRLFGTRGGTallstDKLNYTEAFAGSGEFAIVSLILNiYSAKPNSLILLDEPEVSLHPGAQKRM 324
Cdd:COG4938  110 IFPGKvEVDASSDLVRLVFRPSGNG-----KRIPLSNVGSGVSELLPILLALL-SAAKPGSLLIIEEPEAHLHPKAQSAL 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030 325 MDVLYSIVEQKKhQVVISTHSPVIVN----------TLPKDAIKLFVFDEESETAKIVQNI---------APDEAFIELG 385
Cdd:COG4938  184 AELLAELANSGV-QVIIETHSDYILNglrnlikegkLLDPDDVAVYFFERDGGGSELRRIEidengiisdWPDGFFDEVS 262

                        170
                 ....*....|...
gi 723050030 386 HDINKKTIIVEDK 398
Cdd:COG4938  263 EDLAELFEALLEK 275
AAA_15 pfam13175
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 39-349 6.72e-12

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433011 [Multi-domain]  Cd Length: 392  Bit Score: 67.62  E-value: 6.72e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030   39 QNARIDFQFPITALVGKNGTNKSSVIKAL------------------------FGCPHGKNITRY--------------- 79
Cdd:pfam13175  15 KDTEIDLDEDLTVLIGKNNSGKSSILEALdiflnnkekffeddflvlylkdviKIDKEDLNIFENisfsidieidvefll 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030   80 -WFTTETDEFPDLKLADGSSLKPRYIYGYKNADGRLVEILQARINATKKTIDYWETSRPsvgdNMESISDDLGANSNATR 158
Cdd:pfam13175  95 iLFGYLEIKKKYLCLASKGKAKEYEKTLHPKGANKADLLLELKISDLKKYLKQFKIYIY----NNYYLDEKKNVFDKKSK 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  159 WKKIKKGLVFLDFRSEISAFDRC-------MYHSDFKLRKKKSGVLITKQDYIRSK-------SKYIKKAFDEKLSNLRL 224
Cdd:pfam13175 171 YELPSLKEEFLNSEKEEIKVDKEdlkklinELEKSINYHENVLENLQIKKLLISADrnasdedSEKINSLLGALKQRIFE 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 723050030  225 WGAETIVKNITLAPELVE---HVSFILGKKYK------VIKFLEHRLFGTRGGTALLSTDKLNYTEAFAGSGEFAIVSLI 295
Cdd:pfam13175 251 EALQEELELTEKLKETQNklkEIDKTLAEELKnilfkkIDKLKDFGYPPFLNPEIEIKKDDEDLPLNKNGSGVQRLILLI 330

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 723050030  296 LNIYSA--------KPNSLILLDEPEVSLHPGAQKRMMDVLYSIVEQKKHQVVISTHSPVIV 349
Cdd:pfam13175 331 FFIAEAerkedeieEKNVILAIEEPEAHLHPQAQRVLIKLLKELANDNKTQVIITTHSPHII 392
COG3910 COG3910
Predicted ATPase [General function prediction only];
302-365 2.57e-07

Predicted ATPase [General function prediction only];


Pssm-ID: 443116 [Multi-domain]  Cd Length: 239  Bit Score: 52.08  E-value: 2.57e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723050030 302 KPNSLILLDEPEVSLHPGAQKRMMDVLYSIVEQKKhQVVISTHSPVIVnTLPkDAiKLFVFDEE 365
Cdd:COG3910  151 RGNGLYLLDEPEAALSPSRQLALLALIHDLVREGS-QFIIATHSPILM-AYP-GA-TIYEFDED 210
COG1106 COG1106
ATPase/GTPase, AAA15 family [General function prediction only];
289-354 3.32e-05

ATPase/GTPase, AAA15 family [General function prediction only];


Pssm-ID: 440723 [Multi-domain]  Cd Length: 330  Bit Score: 46.19  E-value: 3.32e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 723050030 289 FAIVSLILNIYsaKPNSLILLDEPEVSLHPGAQKRMMDVLYSIVEQKKHQVVISTHSPVIVNTLPK 354
Cdd:COG1106  211 LALAGALLDAL--AKGGVLLIDEIEASLHPSLLRKLLKLFLDLANKNNAQLIFTTHSTELLDAFLE 274
ABC_UvrA cd03238
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ...
 287-351 2.55e-04

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.


Pssm-ID: 213205 [Multi-domain]  Cd Length: 176  Bit Score: 42.31  E-value: 2.55e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 723050030 287 GEFAIVSLILNIYSAKPNSLILLDEPEVSLHPGAQKRMMDVLYSIVeQKKHQVVISTHSPVIVNT 351
Cdd:cd03238   91 GELQRVKLASELFSEPPGTLFILDEPSTGLHQQDINQLLEVIKGLI-DLGNTVILIEHNLDVLSS 154
ABC_ATPase cd00267
ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large ...
 305-346 2.73e-03

ATP-binding cassette transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide-binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213179 [Multi-domain]  Cd Length: 157  Bit Score: 38.77  E-value: 2.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 723050030 305 SLILLDEPEVSLHPGAQKRMMDVLYSIVEQKKhQVVISTHSP 346
Cdd:cd00267  100 DLLLLDEPTSGLDPASRERLLELLRELAEEGR-TVIIVTHDP 140
ABC_Rad50 cd03240
ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ...
 34-68 3.37e-03

ATP-binding cassette domain of Rad50; The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence.


Pssm-ID: 213207 [Multi-domain]  Cd Length: 204  Bit Score: 39.13  E-value: 3.37e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 723050030  34 FKNIEQNARIDFQFPITALVGKNGTNKSSVIKALF 68
Cdd:cd03240    9 IRSFHERSEIEFFSPLTLIVGQNGAGKTTIIEALK 43
retron_eff_Eco8 NF038234
retron Eco8 family effector endonuclease; This ATPase, found as the effector protein partner ...
 306-360 4.61e-03

retron Eco8 family effector endonuclease; This ATPase, found as the effector protein partner next to a reverse transcriptase in Eco8 type retron systems, is a predicted OLD family endonuclease.


Pssm-ID: 468422 [Multi-domain]  Cd Length: 679  Bit Score: 40.01  E-value: 4.61e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 723050030 306 LILLDEPEVSLHPGAQKRMMDVLYSIVEQKKH-------QVVISTHSPVIVntlpKDAIKLF 360
Cdd:NF038234 275 FIFIDEPELGLHPKLNEQLINEIYESYSFKKKdnktpypKIILATHSPRII----KNIIKLF 332
ABC_ThiQ_thiamine_transporter cd03298
ATP-binding cassette domain of the thiamine transport system; Part of the ...
 287-360 4.75e-03

ATP-binding cassette domain of the thiamine transport system; Part of the binding-protein-dependent transport system tbpA-thiPQ for thiamine and TPP. Probably responsible for the translocation of thiamine across the membrane. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The nucleotide binding domain shows the highest similarity between all members of the family. ABC transporters are a subset of nucleotide hydrolases that contain a signature motif, Q-loop, and H-loop/switch region, in addition to, the Walker A motif/P-loop and Walker B motif commonly found in a number of ATP- and GTP-binding and hydrolyzing proteins.


Pssm-ID: 213265 [Multi-domain]  Cd Length: 211  Bit Score: 39.01  E-value: 4.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 723050030 287 GEFAIVSLILNIYSAKPnsLILLDEPEVSLHPGAQKRMMDVLYSIVEQKKHQVVISTHSpvivntlPKDAIKLF 360
Cdd:cd03298  132 GERQRVALARVLVRDKP--VLLLDEPFAALDPALRAEMLDLVLDLHAETKMTVLMVTHQ-------PEDAKRLA 196
cbiO PRK13634
cobalt transporter ATP-binding subunit; Provisional
 307-345 7.81e-03

cobalt transporter ATP-binding subunit; Provisional


Pssm-ID: 237454 [Multi-domain]  Cd Length: 290  Bit Score: 38.85  E-value: 7.81e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 723050030 307 ILLDEPEVSLHPGAQKRMMDVLYSIVEQKKHQVVISTHS 345
Cdd:PRK13634 167 LVLDEPTAGLDPKGRKEMMEMFYKLHKEKGLTTVLVTHS 205
ABC_MJ0796_LolCDE_FtsE cd03255
ATP-binding cassette domain of the transporters involved in export of lipoprotein and ...
 306-351 7.91e-03

ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and Cell division ATP-binding protein FtsE; This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of lipoproteins from the cytoplasmic membrane (LolCDE). They are clustered together phylogenetically. MacAB is an exporter that confers resistance to macrolides, while the LolCDE system is not a transporter at all. The FtsEX complex resembles an ABC transporter, where FtsE is the ATPase and the membrane subunit FtsX resembles a permease subunit. But rather than transporting any substrate, the complex acts in cell division by undergoing conformational changes that alter the activity of cell wall hydrolases located outside the plasma membrane. The complex is widely conserved in bacteria, but also extremely divergent in sequence between different lineages. The LolCDE complex catalyzes the release of lipoproteins from the cytoplasmic membrane prior to their targeting to the outer membrane.


Pssm-ID: 213222 [Multi-domain]  Cd Length: 218  Bit Score: 38.24  E-value: 7.91e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 723050030 306 LILLDEPEVSLHPGAQKRMMDVLYSIVEQKKHQVVISTHSPVIVNT 351
Cdd:cd03255  161 IILADEPTGNLDSETGKEVMELLRELNKEAGTTIVVVTHDPELAEY 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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