NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|705432744|ref|WP_033510323|]
View 

galactokinase [Bifidobacterium pullorum]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  3.30.70.890|3.30.230.10
EC:  2.7.1.6
Gene Ontology:  GO:0005524|GO:0004335|GO:0005534|GO:0006012|GO:0046835
PubMed:  26862196|15526155
SCOP:  4001389|4000959

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
16-402 8.00e-164

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 465.01  E-value: 8.00e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  16 VARATELFRATFGEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVSDVNPTAVaETELDGL 95
Cdd:COG0153    2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEV-EFDLDDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  96 KARGVDGWAAYPTGVAWAMREAGFdQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGygatdEGRVTLITMA 175
Cdd:COG0153   81 EPGEEDGWANYVRGVAWALQERGY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLG-----LDPVELAKIG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 176 IKSENDMAGASTGGLDQNASMRCTAGHAIRLDCmpglsavDSVSQQEFDLDKYGLELLVVDTQAHHQLNDGQYEQRRRTC 255
Cdd:COG0153  155 QRAENEFVGVPCGIMDQFASALGKKGHALLLDC-------RSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAEC 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 256 EQAAELLGYEHLRAVAEAVaystdpegsLAAVLNCLNDETMKKRVRHVITEIGRVDEFVKAFAAGDIAESGRLFNASHDS 335
Cdd:COG0153  228 EAAAAILGVKSLRDVTLED---------LEAARARLGDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHAS 298

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 705432744 336 LRDDYEVTVPELDVAVDVARA-NGAYGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFEARGFHAPR 402
Cdd:COG0153  299 LRDDYEVSCPELDTLVELALAeAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPD 366
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
16-402 8.00e-164

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 465.01  E-value: 8.00e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  16 VARATELFRATFGEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVSDVNPTAVaETELDGL 95
Cdd:COG0153    2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEV-EFDLDDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  96 KARGVDGWAAYPTGVAWAMREAGFdQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGygatdEGRVTLITMA 175
Cdd:COG0153   81 EPGEEDGWANYVRGVAWALQERGY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLG-----LDPVELAKIG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 176 IKSENDMAGASTGGLDQNASMRCTAGHAIRLDCmpglsavDSVSQQEFDLDKYGLELLVVDTQAHHQLNDGQYEQRRRTC 255
Cdd:COG0153  155 QRAENEFVGVPCGIMDQFASALGKKGHALLLDC-------RSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAEC 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 256 EQAAELLGYEHLRAVAEAVaystdpegsLAAVLNCLNDETMKKRVRHVITEIGRVDEFVKAFAAGDIAESGRLFNASHDS 335
Cdd:COG0153  228 EAAAAILGVKSLRDVTLED---------LEAARARLGDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHAS 298

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 705432744 336 LRDDYEVTVPELDVAVDVARA-NGAYGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFEARGFHAPR 402
Cdd:COG0153  299 LRDDYEVSCPELDTLVELALAeAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPD 366
PRK00555 PRK00555
galactokinase; Provisional
 35-401 3.91e-86

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 266.73  E-value: 3.91e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  35 WAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVSDVNPTAVAeTELDGLKArGVDGWAAYPTGVAWAM 114
Cdd:PRK00555   5 YAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADGSAR-IPLDTTPG-QVTGWAAYAAGVIWAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 115 REAGFdQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGlgygaTDEGRVTLITMAIKSENDMAGASTGGLDQNA 194
Cdd:PRK00555  83 RGAGH-PVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATG-----TRIDRLEQARLAQRAENEYVGAPTGLLDQLA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 195 SMRCTAGHAIRLDCmpglsAVDSVSQQEFDLDKYGLELLVVDTQAHHQLNDGQYEQRRRTCEQAAELLGYEHLRAVAEAV 274
Cdd:PRK00555 157 ALFGAPKTALLIDF-----RDLTVRPVAFDPDAAGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDRG 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 275 AystdpeGSLAAVlnclNDETMKKRVRHVITEIGRVDEFVKAFAAGDIAESGRLFNASHDSLRDDYEVTVPELDVAVDVA 354
Cdd:PRK00555 232 L------AALGAI----ADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSA 301

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 705432744 355 RANGAYGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFEARGFHAP 401
Cdd:PRK00555 302 VRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAAVTAGYPEP 348
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 19-395 2.61e-80

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 252.44  E-value: 2.61e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744   19 ATELFRATFGEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVSDVNPTAVAETELDG-LKA 97
Cdd:TIGR00131   4 IQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERSLDLpLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744   98 RGVDGWAAYPTGVAWAMREAGFDQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGYGATDegrvtLITMAIK 177
Cdd:TIGR00131  84 SEVSDWANYFKGVLHVAQERFNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQ-----ILLRIQV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  178 SENDMAGASTGGLDQNASMRCTAGHAIRLDCmpglsavDSVSQQEFDLDKYGLELLVVDTQAHHQLNDGQYEQRRRTCEQ 257
Cdd:TIGR00131 159 AENHFVGVNCGIMDQAASVLGKEDHALLVEC-------RSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  258 AAELLGYEHLRAVAE-AVAYSTDPEGSLAAVLNCLNdetmkKRVRHVITEIGRVDEFVKAFAAGDIAESGRLFNASHDSL 336
Cdd:TIGR00131 232 AANFLAATDKGALRDfMNEYFARYIARLTKMLPLVE-----ERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASC 306

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  337 RDDYEVTVPELDVAVD-VARANGAYGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFEA 395
Cdd:TIGR00131 307 DDDYECTCPEIDELVCsAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPK 366
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 21-70 3.32e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 85.97  E-value: 3.32e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 705432744   21 ELFRATFGEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKP 70
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
16-402 8.00e-164

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 465.01  E-value: 8.00e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  16 VARATELFRATFGEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVSDVNPTAVaETELDGL 95
Cdd:COG0153    2 LERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADFDEEV-EFDLDDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  96 KARGVDGWAAYPTGVAWAMREAGFdQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGygatdEGRVTLITMA 175
Cdd:COG0153   81 EPGEEDGWANYVRGVAWALQERGY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLG-----LDPVELAKIG 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 176 IKSENDMAGASTGGLDQNASMRCTAGHAIRLDCmpglsavDSVSQQEFDLDKYGLELLVVDTQAHHQLNDGQYEQRRRTC 255
Cdd:COG0153  155 QRAENEFVGVPCGIMDQFASALGKKGHALLLDC-------RSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAEC 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 256 EQAAELLGYEHLRAVAEAVaystdpegsLAAVLNCLNDETMKKRVRHVITEIGRVDEFVKAFAAGDIAESGRLFNASHDS 335
Cdd:COG0153  228 EAAAAILGVKSLRDVTLED---------LEAARARLGDEVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHAS 298

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 705432744 336 LRDDYEVTVPELDVAVDVARA-NGAYGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFEARGFHAPR 402
Cdd:COG0153  299 LRDDYEVSCPELDTLVELALAeAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPD 366
PRK00555 PRK00555
galactokinase; Provisional
 35-401 3.91e-86

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 266.73  E-value: 3.91e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  35 WAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVSDVNPTAVAeTELDGLKArGVDGWAAYPTGVAWAM 114
Cdd:PRK00555   5 YAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADGSAR-IPLDTTPG-QVTGWAAYAAGVIWAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 115 REAGFdQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGlgygaTDEGRVTLITMAIKSENDMAGASTGGLDQNA 194
Cdd:PRK00555  83 RGAGH-PVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATG-----TRIDRLEQARLAQRAENEYVGAPTGLLDQLA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 195 SMRCTAGHAIRLDCmpglsAVDSVSQQEFDLDKYGLELLVVDTQAHHQLNDGQYEQRRRTCEQAAELLGYEHLRAVAEAV 274
Cdd:PRK00555 157 ALFGAPKTALLIDF-----RDLTVRPVAFDPDAAGVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDRG 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 275 AystdpeGSLAAVlnclNDETMKKRVRHVITEIGRVDEFVKAFAAGDIAESGRLFNASHDSLRDDYEVTVPELDVAVDVA 354
Cdd:PRK00555 232 L------AALGAI----ADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSA 301

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 705432744 355 RANGAYGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFEARGFHAP 401
Cdd:PRK00555 302 VRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAAVTAGYPEP 348
PRK05322 PRK05322
galactokinase; Provisional
 23-379 8.81e-85

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 264.03  E-value: 8.81e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  23 FRATFGEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVS-DVNPTAVAETELDGLKARGVD 101
Cdd:PRK05322  10 FAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSaNFEDLGIIEFDLDDLSFDKED 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 102 GWAAYPTGVAWAMREAGFDQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLgygatDEGRVTLITMAIKSEND 181
Cdd:PRK05322  90 DWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNL-----DLDRLELVKLGQKTENE 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 182 MAGASTGGLDQNASMRCTAGHAIRLDCmpglsavdsvSQQEFD---LDKYGLELLVVDTQAHHQLNDGQYEQRRRTCEQA 258
Cdd:PRK05322 165 FIGVNSGIMDQFAIGMGKKDHAILLDC----------NTLEYEyvpLDLGDYVIVIMNTNKRRELADSKYNERRAECEKA 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 259 AELLGYE-HLRAVAEavaysTDPEgSLAAVLNCLNDETMKKRVRHVITEIGRVDEFVKAFAAGDIAESGRLFNASHDSLR 337
Cdd:PRK05322 235 LEELQKKlDIKSLGE-----LTEE-EFDEYSYLIKDETLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLR 308

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 705432744 338 DDYEVTVPELDVAVDVA-RANGAYGARMTGGGFGGSIIALVDK 379
Cdd:PRK05322 309 DDYEVTGLELDTLVEAAwKQEGVLGARMTGAGFGGCAIAIVKK 351
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 19-395 2.61e-80

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 252.44  E-value: 2.61e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744   19 ATELFRATFGEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVSDVNPTAVAETELDG-LKA 97
Cdd:TIGR00131   4 IQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERSLDLpLDG 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744   98 RGVDGWAAYPTGVAWAMREAGFDQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGYGATDegrvtLITMAIK 177
Cdd:TIGR00131  84 SEVSDWANYFKGVLHVAQERFNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQ-----ILLRIQV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  178 SENDMAGASTGGLDQNASMRCTAGHAIRLDCmpglsavDSVSQQEFDLDKYGLELLVVDTQAHHQLNDGQYEQRRRTCEQ 257
Cdd:TIGR00131 159 AENHFVGVNCGIMDQAASVLGKEDHALLVEC-------RSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTT 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  258 AAELLGYEHLRAVAE-AVAYSTDPEGSLAAVLNCLNdetmkKRVRHVITEIGRVDEFVKAFAAGDIAESGRLFNASHDSL 336
Cdd:TIGR00131 232 AANFLAATDKGALRDfMNEYFARYIARLTKMLPLVE-----ERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASC 306

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  337 RDDYEVTVPELDVAVD-VARANGAYGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFEA 395
Cdd:TIGR00131 307 DDDYECTCPEIDELVCsAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPK 366
PRK03817 PRK03817
galactokinase; Provisional
 37-402 1.29e-78

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 246.83  E-value: 1.29e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  37 APGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDtaVRLVSDvNPTAVAETELDGLKARGvdGWAAYPTGVAWAMRE 116
Cdd:PRK03817   5 SPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSEK--FIFYSE-NFNEEKTFELDKLEKLN--SWADYIKGVIWVLEK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 117 AGFDqVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGYGatdegRVTLITMAIKSENDMAGASTGGLDQNASM 196
Cdd:PRK03817  80 RGYE-VGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLS-----KLELALLAREAENEFVGVPCGIMDQFAVA 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 197 RCTAGHAIRLDCMpglsavdSVSQQEFDLDKyGLELLVVDTQAHHQLNDGQYEQRRRTCEQAAELLGYEHLRAVAEAvay 276
Cdd:PRK03817 154 FGKKDHAIFLDTM-------TLEYEYVPFPE-DYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEE--- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 277 stDpegslaavLNCLnDETMKKRVRHVITEIGRVDEFVKAFAAGDIAESGRLFNASHDSLRDDYEVTVPELDVAVDVARA 356
Cdd:PRK03817 223 --D--------LSKL-PPLLRKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALE 291

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 705432744 357 NGAYGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFEARGFHAPR 402
Cdd:PRK03817 292 LGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKRFGIDPK 337
PRK05101 PRK05101
galactokinase; Provisional
 18-396 4.86e-75

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 238.67  E-value: 4.86e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  18 RATELFRATFGEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVS-DVNpTAVAETELDG-L 95
Cdd:PRK05101   6 KTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAaDYD-NQQDEFSLDApI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  96 KARGVDGWAAYPTGVAWAMREAGFDqVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGYGATDegrVTLITMa 175
Cdd:PRK05101  85 VPHPEQQWANYVRGVVKHLQERNPD-FGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAE---IALNGQ- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 176 iKSENDMAGASTGGLDQNASMRCTAGHAIRLDC---------MPGlsavdsvsqqefdldkyGLELLVVDTQAHHQLNDG 246
Cdd:PRK05101 160 -EAENQFVGCNCGIMDQLISALGKKDHALLIDCrsletkavpMPE-----------------GVAVVIINSNVKRGLVDS 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 247 QYEQRRRTCEQAAELLGYEHLRAVAEAvaystdpegSLAAVLNCLNDETMKkRVRHVITEIGRVDEFVKAFAAGDIAESG 326
Cdd:PRK05101 222 EYNTRRQQCETAARFFGVKALRDVTLE---------QFNAVAAELDPVVAK-RARHVITENARTLEAASALAAGDLKRMG 291

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 705432744 327 RLFNASHDSLRDDYEVTVPELDVAVDVARA----NGayGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFEAR 396
Cdd:PRK05101 292 ELMAESHASMRDDFEITVPQIDTLVEIVKAvigdQG--GVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAK 363
PLN02521 PLN02521
galactokinase
 17-390 4.06e-38

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 143.69  E-value: 4.06e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  17 ARATELFRATFGEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVSDVN---PTAVAETELD 93
Cdd:PLN02521  33 ARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSKKLRIANVNdkyTTCTFPADPD 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  94 GLKARGVDGWAAY----PTGVAWAMREAGFD--QVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGYGATDeg 167
Cdd:PLN02521 113 QEVDLANHKWGNYficgYKGVFEFLKSKGVDvgPPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKE-- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 168 rvtLITMAIKSENDMaGASTGGLDQNASMRCTAGHAIRLDCMPgLSAVDSVsqqefdLDKYGLELLVvdtqahHQLNDGQ 247
Cdd:PLN02521 191 ---VAQFTCKCERHI-GTQSGGMDQAISIMAQQGVAKLIDFNP-VRATDVQ------LPAGGTFVIA------NSLAESN 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 248 --------YEQRRRTCEQAAELLGYEHLRAVAEAVA-YST--DPEG-------------SLAAVLNCLNDE--------- 294
Cdd:PLN02521 254 kavtaatnYNNRVVECRLAAIVLAVKLGMSAEEAISkVKTlsDVEGlcvsfagshgssdPAVAVKELLHEGpytaeeiee 333

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 295 --------------------------TMKKRVRHVITEIGRVDEFVKAFAAGDIAES-----GRLFNASHDSLRDDYEVT 343
Cdd:PLN02521 334 ilgesltsifknsptslavlkaakhfKLHQRAVHVYSEAKRVHAFRDTVSSSLSEEEklkklGDLMNESHYSCSVLYECS 413

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 705432744 344 VPELDVAVDVARANGAYGARMTGGGFGGSIIALVdkgRSQEVAQLIA 390
Cdd:PLN02521 414 CPELEELVKVCRDNGALGARLTGAGWGGCAVALV---KEAIVPQFIL 457
PLN02865 PLN02865
galactokinase
 28-394 9.34e-35

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 133.39  E-value: 9.34e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  28 GEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVSDVNPTAV--------AETELDGLKARG 99
Cdd:PLN02865  26 NSGEVRVVVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEGEVrfrvdeiqHPIANVSSDSKE 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 100 VDGWAAYPTGVAWAMREAGFDQVRGFdAAFVSCVP--LGSGLSSSAAMTCSTALALDDVYGLGYGATDEgrvtlITMAIK 177
Cdd:PLN02865 106 ESNWGDYARGAVYALQSRGHALSQGI-TGYISGSEglDSSGLSSSAAVGVAYLLALENANNLTVSPEDN-----IELDRL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 178 SENDMAGASTGGLDQNASMRCTAGHAIRLDCMPGLSAVDSVSQQEFDLDKYGLELLVVDTQAHHQLNDGQYEQRRRTCEQ 257
Cdd:PLN02865 180 IENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPGGEKPFKILLAFSGLRHALTNKPGYNLRVSECQE 259

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 258 AAELLGYEHLRAVAEAVAYSTDPEGSLAavLNCLNDETMKKRVRHVITEIGRVDEFVKAFAAGDIAESGRLFNASHDSLR 337
Cdd:PLN02865 260 AARFLLEASGNDELEPLLCNVEPEVYEA--HKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLSSI 337

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 705432744 338 DDYEVTVPEL-DVAVDVARANGAYGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFE 394
Cdd:PLN02865 338 ENYECGCEPLiQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYE 395
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 37-377 4.61e-24

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 100.69  E-value: 4.61e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  37 APGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTAVRLVSD-----VNPTAVAETELDGLKArgvdgwaayptGVA 111
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPdlggtLDLDPLADAALRYIKA-----------AIE 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 112 WAMREAGFDqVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGYGATDegrvtLITMAIKSENDMAGAStGGLD 191
Cdd:COG1577   70 AALEYLGLP-LKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYGVELSKEE-----LFKLALEAEKIVHGNP-SGLD 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 192 QNASmrcTAGHAIRLDcmpglsavDSVSQQEFDLDKyGLELLVVDTqahhqlndgqyEQRRRTceqaAELLgyehlRAVA 271
Cdd:COG1577  143 TAAS---TYGGPIYYQ--------RGDRAEPLELPK-NLPLVVGDT-----------GVPAST----KELV-----AKVR 190

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 272 EAvaYSTDPEgslaavlnclndetmkkRVRHVITEIGR-VDEFVKAFAAGDIAESGRLFNASHDsLRDDYEVTVPELDVA 350
Cdd:COG1577  191 KL--KERNPE-----------------LYEAFLEEIGDlVEEAIEALEEGDLEALGELMNENHG-LLRALGVSTPELDRL 250

                        330       340
                 ....*....|....*....|....*..
gi 705432744 351 VDVARANGAYGARMTGGGFGGSIIALV 377
Cdd:COG1577  251 VEAARKAGALGAKLTGAGGGGCVIALA 277
PTZ00290 PTZ00290
galactokinase; Provisional
 13-396 2.08e-22

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 98.74  E-value: 2.08e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  13 DDGVARATELFRATFG-EEPAGV-WA----APGRVNLIGEHTDYNAGLCLPIALPHRTFL---ALKPREDTAVRLVSdvn 83
Cdd:PTZ00290  12 DSTLSTLKPIFLETFKvENDADVeWLlftfAPGRVNFIGEHVDYMGGYVCPAAVLEGCHIlvgRVKHFCDHKLRFAT--- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  84 pTAVAETELDGL-KARGVDGWAAYPTG-VAWAMREAGF----DQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDV- 156
Cdd:PTZ00290  89 -ETDEHFVLDHLgGAKHNKAWTTFVRGaATLRLNRLGVaidaPSLQGVCMVVHGTLPMGAGMSASASFGVALLNAINTVv 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 157 --------------YGLGYGATDEGRVTLITMAIKSENDMAGASTGGLDQNASMRCTAGHAIRLDCmpglsavDSVSQQE 222
Cdd:PTZ00290 168 trrykgcptspgrrYSILPPMSKEELIELAKQARRIETEFCGVNVGIMDQFISAFAEEDKFMFLDC-------KSLTFES 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 223 FDLDKY---GLELLVVDTQAHHQL---NDGQYEQRRRTCEQAAELLGYEHLRAVA----------EAVAYSTDPEGSLAA 286
Cdd:PTZ00290 241 HDMTPLlgdGACFLLIDSMIKHDLlggTAGMYNTVRSDQEGAQKKIGKHRYRGKPftfsdlvrnpKKYTFDGDVVAFMES 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 287 VLNCLNDETMKKRVRHVITEIgRVDEFVKAFAAG-------DIAESGRLFNASHDSLRDDYEVTVPELD-VAVDVARANG 358
Cdd:PTZ00290 321 CKPLMTPGEFERGTYNIMEQI-RTLEFIKLNDPElplsreeRFRKAGEILNAGHQGMRDLMKITTPELDfIHELINEEKG 399

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 705432744 359 AYGARMTGGGFGGSIIALVDKGRSQEVAQLIADEFEAR 396
Cdd:PTZ00290 400 VAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKAR 437
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 21-70 3.32e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 85.97  E-value: 3.32e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 705432744   21 ELFRATFGEEPAGVWAAPGRVNLIGEHTDYNAGLCLPIALPHRTFLALKP 70
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 37-376 2.50e-19

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 87.35  E-value: 2.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744   37 APGRVNLIGEHTDYNAGLCLPIALPHRTFLALKPREDTaVRLVSDV--NPTAVAETELDGLKARGVDgwaayptgvawAM 114
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVIESSDG-SFIESDLgrGSLDDAPDELDGLKYVLAE-----------FL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  115 REAGFDQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGYGATDegrvtLITMAIKSENDMAGASTgGLDqna 194
Cdd:TIGR00549  69 SRFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEE-----LAELANEAEKIAHGKPS-GID--- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  195 SMRCTAGHAIRLDcmpglsavdsvSQQEFD--LDKYGLELLVVDTQAHhqlndgqyeqrRRTceqaAELLgyEHLRAVAE 272
Cdd:TIGR00549 140 TATSTSGGPVYFE-----------KGEGEFtkLISLDGYFVIADTGVS-----------GST----KEAV--ARVRQLLE 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  273 AvaystdpegslaavlnclNDETMKKRVRHvITEIgrVDEFVKAFAAGDIAESGRLFNASHDSLrDDYEVTVPELDVAVD 352
Cdd:TIGR00549 192 R------------------FPELIDSIMDA-IGEL--TLEAKAALQDGDVESLGELMNINQGLL-KALGVSHPKLDQLVE 249

                         330       340
                  ....*....|....*....|....
gi 705432744  353 VARANGAYGARMTGGGFGGSIIAL 376
Cdd:TIGR00549 250 IARKAGALGAKLTGAGGGGCMIAL 273
PRK03926 PRK03926
mevalonate kinase; Provisional
 36-390 3.19e-14

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 72.78  E-value: 3.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  36 AAPGRVNLIGEHTD-YN-AGLCLPIALphRTFLALKPRED-----TAVRLVSDVNPTAVAETELdglkargvdgwaaypt 108
Cdd:PRK03926   5 SAPGKIYLFGEHAVvYGkPAIACAIDL--RTYVRAEFNDDsiyieSDYGKTGEKHPYVSAAIEK---------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 109 gvawaMREagFDQVRGFDAAFVSCVPLGSGLSSSAAMTCSTALALDDVYGLGYGATDEGRvtlitMAIKSENDMAGASTG 188
Cdd:PRK03926  67 -----MRE--EADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAK-----LGHKVELLVQGAASP 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 189 gLDQNASmrcTAGHAIRLDCMPGLSAVDsvsqqefdldkygLELLVVDTqahhqlndgqyeqrrrtceqaaellgyehlr 268
Cdd:PRK03926 135 -TDTYVS---TMGGFVTIPDRKKLPFPE-------------CGIVVGYT------------------------------- 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744 269 avaeAVAYSTdpeGSLAAVLNCLNdETMKKRVRHVITEIGRVDEFVKAF-AAGDIAESGRLFNASHdSLRDDYEVTVPEL 347
Cdd:PRK03926 167 ----GSSGST---KELVANVRKLK-EEYPELIEPILSSIGKISEKGEELiLSGDYVSLGELMNINQ-GLLDALGVSTKEL 237

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 705432744 348 DVAVDVARANGAYGARMTGGGFGGSIIALVDKGRSQEVAQLIA 390
Cdd:PRK03926 238 SELIYAARTAGALGAKITGAGGGGCMVALAAPEKQSEVATAIK 280
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 313-397 1.39e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 57.48  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705432744  313 FVKAFAAGDIAESGRLFNASHDSL--RDDYEVTVPELDVAVDVARANGaYGARMTGGGFGGSIIALVDkgrSQEVAQLIA 390
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELG-LGAKLSGSGGGPTVFALFK---DEDDAEEVA 76


                  ....*..
gi 705432744  391 DEFEARG 397
Cdd:pfam08544  77 RALREAG 83
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 131-196 1.19e-08

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 51.01  E-value: 1.19e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 705432744  131 SCVPLGSGLSSSAAMTCSTALALDDVYGLGygatdegrvtLITMAIKSENDMAGASTGGLDQNASM 196
Cdd:pfam00288   6 SNIPLGAGLGSSAALAVALLLALNELFGLP----------LAKLALEAEELAGGGRGGGMDVAASL 61
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 310-376 2.42e-07

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 52.16  E-value: 2.42e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 705432744 310 VDEFVKAFAAGDIAESGRLFNASHDSLRDdYEVTVPELDVAVDVARANGAYGARMTGGGFGGSIIAL 376
Cdd:PTZ00298 227 VSEAKEALQKGNLFRVGELMNANHDLCQK-LTVSCRELDSIVQTCRTYGALGAKMSGTGRGGLVVAL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH