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Conserved domains on  [gi|705423160|ref|WP_033505273|]
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hypothetical protein [Bifidobacterium pullorum]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
iso_D2_wall_anc super family cl41511
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
 107-193 1.33e-03

SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.


The actual alignment was detected with superfamily member NF033902:

Pssm-ID: 468234 [Multi-domain]  Cd Length: 533  Bit Score: 39.74  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705423160 107 TTLTSGASRDLASVLSDYAAEHGLYEQSATADAYGTAHFGVLPAGLYLLTRTGVAQDGESCATmPMLVGVPAVE----AG 182
Cdd:NF033902 110 AKLTTAAAGTAAAFATTLGDTTKTTTTTGTTDADGTAKFSNLPLGLYLVEETDAPYSVVVKAA-PFLVTVPLTNptgnAT 188

                         90
                 ....*....|.
gi 705423160 183 GIVYDVTVDPK 193
Cdd:NF033902 189 KWNYDVHVYPK 199
 
Name Accession Description Interval E-value
iso_D2_wall_anc NF033902
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
 107-193 1.33e-03

SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.


Pssm-ID: 468234 [Multi-domain]  Cd Length: 533  Bit Score: 39.74  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705423160 107 TTLTSGASRDLASVLSDYAAEHGLYEQSATADAYGTAHFGVLPAGLYLLTRTGVAQDGESCATmPMLVGVPAVE----AG 182
Cdd:NF033902 110 AKLTTAAAGTAAAFATTLGDTTKTTTTTGTTDADGTAKFSNLPLGLYLVEETDAPYSVVVKAA-PFLVTVPLTNptgnAT 188

                         90
                 ....*....|.
gi 705423160 183 GIVYDVTVDPK 193
Cdd:NF033902 189 KWNYDVHVYPK 199
 
Name Accession Description Interval E-value
iso_D2_wall_anc NF033902
SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits ...
 107-193 1.33e-03

SpaH/EbpB family LPXTG-anchored major pilin; Members of this family are pilin major subunits whose structure includes an LPXTG motif-containing signal (see TIGR01167) near the C-terminus, for processing by sortases. Most contain a recognizable D2-type fimbrial isopeptide formation domain (see TIGR04226), in which Lys-to-Asn isopeptide bond formation provides additional structural integrity to support adhesion despite shear. For proper members of this subfamily, lengths fall typically in the range of 460 to 640 amino acids in length. Many members of this family contribute to the virulence of certain Gram-positive pathogens, including SpaA, SpaD, and SpaH from Corynebacterium diphtheriae, and EbpB and EbpC from Enterococcus faecalis.


Pssm-ID: 468234 [Multi-domain]  Cd Length: 533  Bit Score: 39.74  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 705423160 107 TTLTSGASRDLASVLSDYAAEHGLYEQSATADAYGTAHFGVLPAGLYLLTRTGVAQDGESCATmPMLVGVPAVE----AG 182
Cdd:NF033902 110 AKLTTAAAGTAAAFATTLGDTTKTTTTTGTTDADGTAKFSNLPLGLYLVEETDAPYSVVVKAA-PFLVTVPLTNptgnAT 188

                         90
                 ....*....|.
gi 705423160 183 GIVYDVTVDPK 193
Cdd:NF033902 189 KWNYDVHVYPK 199
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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