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Conserved domains on  [gi|700663582|ref|WP_033181108|]
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MULTISPECIES: phosphonate ABC transporter, permease protein PhnE [Rhizobium]

Protein Classification

PhnE/PtxC family ABC transporter permease( domain architecture ID 11466536)

PhnE/PtxC family ABC transporter permease is the transmembrane subunit found in a periplasmic binding protein (PBP)-dependent ABC transport system, which may be involved in the transport of phosphonate, phosphate, or phosphite ions

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 216-442 2.11e-73

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 230.74  E-value: 2.11e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582 216 VSGPRIKPDQSNLSLAFDDIWNNSEWQHGDVWTKLFQTIVMAFLGTLLGSLTAFPLAFLAARNITPNRLLNQILKRFFDF 295
Cdd:COG3639   19 FDLGRLIDGLPNLADFLSRFFPPDWSYLPDLLSALLETLAIALLGTLLGAVLALPLAFLAARNLAPNPWVRLLARRLLNV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582 296 LRSVDMLIWALFLTRAFGPGPLAGSGAIFLTETGTLGKLYSEGLENIDNKPREGIKSTGAQTVLVHRYGIMPQIVPIFVS 375
Cdd:COG3639   99 LRAIPELVWALIFVAAVGLGPFAGVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQVLPQFLS 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 700663582 376 QTLYQWESNVRGATIIGAVGAGGIGLKLWEAMRTnANWENVAYMVILILIVVFIFDTASNALRHRLM 442
Cdd:COG3639  179 YTLYRFEINIRAATVLGLVGAGGIGLLLNEAIRL-FQYDEVAAILLVILVLVLLIDLLSARLRRRLI 244
 
Name Accession Description Interval E-value
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 216-442 2.11e-73

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 230.74  E-value: 2.11e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582 216 VSGPRIKPDQSNLSLAFDDIWNNSEWQHGDVWTKLFQTIVMAFLGTLLGSLTAFPLAFLAARNITPNRLLNQILKRFFDF 295
Cdd:COG3639   19 FDLGRLIDGLPNLADFLSRFFPPDWSYLPDLLSALLETLAIALLGTLLGAVLALPLAFLAARNLAPNPWVRLLARRLLNV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582 296 LRSVDMLIWALFLTRAFGPGPLAGSGAIFLTETGTLGKLYSEGLENIDNKPREGIKSTGAQTVLVHRYGIMPQIVPIFVS 375
Cdd:COG3639   99 LRAIPELVWALIFVAAVGLGPFAGVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQVLPQFLS 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 700663582 376 QTLYQWESNVRGATIIGAVGAGGIGLKLWEAMRTnANWENVAYMVILILIVVFIFDTASNALRHRLM 442
Cdd:COG3639  179 YTLYRFEINIRAATVLGLVGAGGIGLLLNEAIRL-FQYDEVAAILLVILVLVLLIDLLSARLRRRLI 244
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 246-441 2.87e-63

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 204.70  E-value: 2.87e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582  246 VWTKLFQTIVMAFLGTLLGSLTAFPLAFLAARNITPNRLLNQILKRFFDFLRSVDMLIWALFLTRAFGPGPLAGSGAIFL 325
Cdd:TIGR01097  56 ILKALLETLAMAILGTVLAAVLAVPLALLAARNITPSPWLYGLARLLLNFLRAIPELVWALIFVAAVGLGPFAGVLALAF 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582  326 TETGTLGKLYSEGLENIDNKPREGIKSTGAQTVLVHRYGIMPQIVPIFVSQTLYQWESNVRGATIIGAVGAGGIGLKLWE 405
Cdd:TIGR01097 136 HTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFLSYTLYRFEINVRAAAVLGLVGAGGIGLELDT 215

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 700663582  406 AMRTnANWENVAYMVILILIVVFIFDTASNALRHRL 441
Cdd:TIGR01097 216 AIGL-FDYDEVSAIILVILVVVVIIDLISARLRRRL 250
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 250-432 1.66e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 57.29  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582 250 LFQTIVMAFLGTLLGSLTAFPLAFLAARNitpNRLLNQILKRFFDFLRSVDMLIWALFLTRAFGPGPLAGSGAIFLTETG 329
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARK---RGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPAL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582 330 TLG---------KLYSEGLENIDNKPREGIKSTGAQTVLVHRYGIMPQIVPIFVSQTLYQWESNVRGATIIGAVGAGGIG 400
Cdd:cd06261   78 ILAllliapfarLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAP 157

                        170       180       190
                 ....*....|....*....|....*....|..
gi 700663582 401 LKLWEAMRTNANWENVAYMVILILIVVFIFDT 432
Cdd:cd06261  158 GPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
 
Name Accession Description Interval E-value
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 216-442 2.11e-73

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 230.74  E-value: 2.11e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582 216 VSGPRIKPDQSNLSLAFDDIWNNSEWQHGDVWTKLFQTIVMAFLGTLLGSLTAFPLAFLAARNITPNRLLNQILKRFFDF 295
Cdd:COG3639   19 FDLGRLIDGLPNLADFLSRFFPPDWSYLPDLLSALLETLAIALLGTLLGAVLALPLAFLAARNLAPNPWVRLLARRLLNV 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582 296 LRSVDMLIWALFLTRAFGPGPLAGSGAIFLTETGTLGKLYSEGLENIDNKPREGIKSTGAQTVLVHRYGIMPQIVPIFVS 375
Cdd:COG3639   99 LRAIPELVWALIFVAAVGLGPFAGVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQVLPQFLS 178

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 700663582 376 QTLYQWESNVRGATIIGAVGAGGIGLKLWEAMRTnANWENVAYMVILILIVVFIFDTASNALRHRLM 442
Cdd:COG3639  179 YTLYRFEINIRAATVLGLVGAGGIGLLLNEAIRL-FQYDEVAAILLVILVLVLLIDLLSARLRRRLI 244
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 246-441 2.87e-63

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 204.70  E-value: 2.87e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582  246 VWTKLFQTIVMAFLGTLLGSLTAFPLAFLAARNITPNRLLNQILKRFFDFLRSVDMLIWALFLTRAFGPGPLAGSGAIFL 325
Cdd:TIGR01097  56 ILKALLETLAMAILGTVLAAVLAVPLALLAARNITPSPWLYGLARLLLNFLRAIPELVWALIFVAAVGLGPFAGVLALAF 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582  326 TETGTLGKLYSEGLENIDNKPREGIKSTGAQTVLVHRYGIMPQIVPIFVSQTLYQWESNVRGATIIGAVGAGGIGLKLWE 405
Cdd:TIGR01097 136 HTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQVLPQFLSYTLYRFEINVRAAAVLGLVGAGGIGLELDT 215

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 700663582  406 AMRTnANWENVAYMVILILIVVFIFDTASNALRHRL 441
Cdd:TIGR01097 216 AIGL-FDYDEVSAIILVILVVVVIIDLISARLRRRL 250
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 250-432 1.66e-09

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 57.29  E-value: 1.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582 250 LFQTIVMAFLGTLLGSLTAFPLAFLAARNitpNRLLNQILKRFFDFLRSVDMLIWALFLTRAFGPGPLAGSGAIFLTETG 329
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARK---RGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPAL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 700663582 330 TLG---------KLYSEGLENIDNKPREGIKSTGAQTVLVHRYGIMPQIVPIFVSQTLYQWESNVRGATIIGAVGAGGIG 400
Cdd:cd06261   78 ILAllliapfarLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAP 157

                        170       180       190
                 ....*....|....*....|....*....|..
gi 700663582 401 LKLWEAMRTNANWENVAYMVILILIVVFIFDT 432
Cdd:cd06261  158 GPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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