MULTISPECIES: choline ABC transporter substrate-binding protein [Pseudomonas]
Protein Classification
choline ABC transporter substrate-binding protein( domain architecture ID 10799157)
choline ABC transporter substrate-binding protein functions as the initial receptor in the ABC transport of choline
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| ABC_choline_bnd | TIGR03414 | choline ABC transporter, periplasmic binding protein; Partial phylogenetic profiling () vs. ... |
21-313 | 0e+00 | |||||
choline ABC transporter, periplasmic binding protein; Partial phylogenetic profiling () vs. the genome property of glycine betaine biosynthesis from choline consistently reveals a member of this ABC transporter periplasmic binding protein as the best match, save for the betaine biosynthesis enzymes themselves. Genomes often carry several paralogs, one encoded together with the permease and ATP-binding components and another encoded next to a choline-sulfatase gene, suggesting that different members of this protein family interact with shared components and give some flexibility in substrate. Of two members from Sinorhizobium meliloti 1021, one designated ChoX has been shown experimentally to bind choline (though not various related compounds such as betaine) and to be required for about 60 % of choline uptake. Members of this protein have an invariant Cys residue near the N-terminus and likely are lipoproteins. [Transport and binding proteins, Amino acids, peptides and amines] : Pssm-ID: 188316 Cd Length: 290 Bit Score: 501.05 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | |||||
| ABC_choline_bnd | TIGR03414 | choline ABC transporter, periplasmic binding protein; Partial phylogenetic profiling () vs. ... |
21-313 | 0e+00 | |||||
choline ABC transporter, periplasmic binding protein; Partial phylogenetic profiling () vs. the genome property of glycine betaine biosynthesis from choline consistently reveals a member of this ABC transporter periplasmic binding protein as the best match, save for the betaine biosynthesis enzymes themselves. Genomes often carry several paralogs, one encoded together with the permease and ATP-binding components and another encoded next to a choline-sulfatase gene, suggesting that different members of this protein family interact with shared components and give some flexibility in substrate. Of two members from Sinorhizobium meliloti 1021, one designated ChoX has been shown experimentally to bind choline (though not various related compounds such as betaine) and to be required for about 60 % of choline uptake. Members of this protein have an invariant Cys residue near the N-terminus and likely are lipoproteins. [Transport and binding proteins, Amino acids, peptides and amines] Pssm-ID: 188316 Cd Length: 290 Bit Score: 501.05 E-value: 0e+00
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| PBP2_ChoX | cd13640 | Substrate binding domain of ABC-type choline transport system; the type 2 periplasmic binding ... |
29-297 | 4.37e-145 | |||||
Substrate binding domain of ABC-type choline transport system; the type 2 periplasmic binding protein fold; This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to choline and acetylcholine for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as choline and betaines. Choline is necessary for the biosynthesis of glycine betaine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. In the case of the Sinorhizobium meliloti choline uptake system ChoVWX, ChoV is the nucleotide-binding domain that provides energy for the transport process via ATP hydrolysis, ChoW is the integral transmembrane protein that forms the substrate translaocation pathway, and ChoX is the substrate-binding domain. ChoX belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. Pssm-ID: 270358 [Multi-domain] Cd Length: 266 Bit Score: 408.90 E-value: 4.37e-145
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| ProX | COG2113 | ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport ... |
18-299 | 2.91e-109 | |||||
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport and metabolism]; Pssm-ID: 441716 [Multi-domain] Cd Length: 297 Bit Score: 319.49 E-value: 2.91e-109
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| OpuAC | pfam04069 | Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity ... |
28-268 | 1.74e-48 | |||||
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis. The family member OpuBC is closely related, and involved in choline transport. Choline is necessary for the biosynthesis of glycine betaine. L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA). Pssm-ID: 397954 [Multi-domain] Cd Length: 257 Bit Score: 162.88 E-value: 1.74e-48
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| Name | Accession | Description | Interval | E-value | |||||
| ABC_choline_bnd | TIGR03414 | choline ABC transporter, periplasmic binding protein; Partial phylogenetic profiling () vs. ... |
21-313 | 0e+00 | |||||
choline ABC transporter, periplasmic binding protein; Partial phylogenetic profiling () vs. the genome property of glycine betaine biosynthesis from choline consistently reveals a member of this ABC transporter periplasmic binding protein as the best match, save for the betaine biosynthesis enzymes themselves. Genomes often carry several paralogs, one encoded together with the permease and ATP-binding components and another encoded next to a choline-sulfatase gene, suggesting that different members of this protein family interact with shared components and give some flexibility in substrate. Of two members from Sinorhizobium meliloti 1021, one designated ChoX has been shown experimentally to bind choline (though not various related compounds such as betaine) and to be required for about 60 % of choline uptake. Members of this protein have an invariant Cys residue near the N-terminus and likely are lipoproteins. [Transport and binding proteins, Amino acids, peptides and amines] Pssm-ID: 188316 Cd Length: 290 Bit Score: 501.05 E-value: 0e+00
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| PBP2_ChoX | cd13640 | Substrate binding domain of ABC-type choline transport system; the type 2 periplasmic binding ... |
29-297 | 4.37e-145 | |||||
Substrate binding domain of ABC-type choline transport system; the type 2 periplasmic binding protein fold; This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to choline and acetylcholine for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as choline and betaines. Choline is necessary for the biosynthesis of glycine betaine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. In the case of the Sinorhizobium meliloti choline uptake system ChoVWX, ChoV is the nucleotide-binding domain that provides energy for the transport process via ATP hydrolysis, ChoW is the integral transmembrane protein that forms the substrate translaocation pathway, and ChoX is the substrate-binding domain. ChoX belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. Pssm-ID: 270358 [Multi-domain] Cd Length: 266 Bit Score: 408.90 E-value: 4.37e-145
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| ProX | COG2113 | ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport ... |
18-299 | 2.91e-109 | |||||
ABC-type proline/glycine betaine transport system, periplasmic component [Amino acid transport and metabolism]; Pssm-ID: 441716 [Multi-domain] Cd Length: 297 Bit Score: 319.49 E-value: 2.91e-109
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| PBP2_Osm_BCP_like | cd13535 | Substrate binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline ... |
29-284 | 6.38e-56 | |||||
Substrate binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline transport system and related proteins; the type 2 periplasmic binding protein fold; This family is part of a high affinity multicomponent binding-protein-dependent ATP-binding cassette transport system specific to certain quaternary ammonium compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as betaines, choline, and L-proline. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. Pssm-ID: 270253 [Multi-domain] Cd Length: 277 Bit Score: 182.75 E-value: 6.38e-56
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| PBP2_OpuAC_like | cd13639 | Substrate binding domain of Lactococcus lactis ABC-type transporter OpuA and related proteins; ... |
49-295 | 1.94e-49 | |||||
Substrate binding domain of Lactococcus lactis ABC-type transporter OpuA and related proteins; the type 2 periplasmic binding protein fold; This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to betaine compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine and proline betaine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. Pssm-ID: 270357 [Multi-domain] Cd Length: 254 Bit Score: 165.02 E-value: 1.94e-49
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| OpuAC | pfam04069 | Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity ... |
28-268 | 1.74e-48 | |||||
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis. The family member OpuBC is closely related, and involved in choline transport. Choline is necessary for the biosynthesis of glycine betaine. L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA). Pssm-ID: 397954 [Multi-domain] Cd Length: 257 Bit Score: 162.88 E-value: 1.74e-48
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| PBP2_BCP_2 | cd13643 | Substrate-binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline ... |
49-293 | 1.09e-10 | |||||
Substrate-binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline transport system-like; the type 2 periplasmic-binding protein fold; This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to certain quaternary ammonium compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine, proline betaine, choline, and carnitine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. Pssm-ID: 270361 [Multi-domain] Cd Length: 283 Bit Score: 61.15 E-value: 1.09e-10
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| PBP2_BCP_1 | cd13642 | Substrate-binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline ... |
66-217 | 9.52e-07 | |||||
Substrate-binding domain of osmoregulatory ABC-type glycine betaine/choline/L-proline transport system-like; the type 2 periplasmic-binding protein fold; This subfamily is part of a high affinity multicomponent binding-protein-dependent transport system specific to certain quaternary ammonium compounds for osmoregulation. The periplasmic substrate-binding domain, which is often fused to the permease component of the ATP-binding cassette transporter complex, is involved in uptake of osmoprotectants (also termed compatible solutes) such as glycine betaine, proline betaine, choline, and carnitine. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. This domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. Pssm-ID: 270360 [Multi-domain] Cd Length: 292 Bit Score: 49.31 E-value: 9.52e-07
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| PBP2_EcProx_like | cd13638 | Substrate binding domain of Escherichia coli betaine transport system-like; the type 2 ... |
24-212 | 2.09e-05 | |||||
Substrate binding domain of Escherichia coli betaine transport system-like; the type 2 periplasmic binding protein fold; This group includes the periplasmic substrate-binding protein ProX. ProX from the Escherichia coli ATP-binding cassette transport system ProU binds the compatible solutes glycine betaine and proline betaine with high affinity and specificity. Many microorganisms accumulate these compatible solutes in response to high osmolarity to offset the loss of cell water. The ProX belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap. Pssm-ID: 270356 [Multi-domain] Cd Length: 299 Bit Score: 45.36 E-value: 2.09e-05
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