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Conserved domains on  [gi|696312154|ref|WP_032887604|]
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MULTISPECIES: ANTAR domain-containing response regulator [Pseudomonas]

Protein Classification

ANTAR domain-containing response regulator( domain architecture ID 11467116)

ANTAR domain-containing response regulator, a response regulator with a signal receiver (REC) domain and RNA binding antiterminator (ANTAR) domain involved in transcriptional antitermination, similar to Mycobacterium tuberculosis transcriptional regulatory protein pdtaR that is a member of the two-component regulatory system pdtaR/pdtaS

Gene Ontology:  GO:0000160
PubMed:  11557134|20226724|16740923|11796212|18076326|11934609
SCOP:  4003632

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-191 2.13e-57

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 179.00  E-value: 2.13e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   1 MLRILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFT 80
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154  81 DEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQLQARDQQLAERKRIELAKGMLMKMKACNEEE 160
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDE 162

                        170       180       190
                 ....*....|....*....|....*....|.
gi 696312154 161 AYTLMRRQAMSRQQKLIQVAEQIIAMSELLG 191
Cdd:COG3707  163 AYRLLRKQAMDRRVKLAEVAEAILAAAELLK 193
 
Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-191 2.13e-57

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 179.00  E-value: 2.13e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   1 MLRILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFT 80
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154  81 DEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQLQARDQQLAERKRIELAKGMLMKMKACNEEE 160
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDE 162

                        170       180       190
                 ....*....|....*....|....*....|.
gi 696312154 161 AYTLMRRQAMSRQQKLIQVAEQIIAMSELLG 191
Cdd:COG3707  163 AYRLLRKQAMDRRVKLAEVAEAILAAAELLK 193
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 2-119 1.80e-12

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 61.28  E-value: 1.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   2 LRILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFTD 81
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVLLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 696312154  82 EHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAMAR 119
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 130-184 9.20e-12

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 57.49  E-value: 9.20e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 696312154   130 LQARDQQLAERKRIELAKGMLMKMKACNEEEAYTLMRRQAMSRQQKLIQVAEQII 184
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAIV 55
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 137-181 1.58e-11

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 56.57  E-value: 1.58e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 696312154  137 LAERKRIELAKGMLMKMKACNEEEAYTLMRRQAMSRQQKLIQVAE 181
Cdd:pfam03861   2 LESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-140 5.09e-04

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 39.83  E-value: 5.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLpARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTD 81
Cdd:PRK11361   6 RILIVDDEDNVRRMLSTAFALQGFETHCANNGRTAL-HLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRtPVILMTA 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 696312154  82 EHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAMARfesdQALRAQLQARDQQLAER 140
Cdd:PRK11361  85 YAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQL----QSMKKEIRHLHQALSTS 139
 
Name Accession Description Interval E-value
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
 1-191 2.13e-57

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 179.00  E-value: 2.13e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   1 MLRILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFT 80
Cdd:COG3707    3 GLRVLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPAPVILLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154  81 DEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQLQARDQQLAERKRIELAKGMLMKMKACNEEE 160
Cdd:COG3707   83 AYSDPELIERALEAGVSAYLVKPLDPEDLLPALELALARFRELRALRRELAKLREALEERKLIERAKGILMERRGLSEDE 162

                        170       180       190
                 ....*....|....*....|....*....|.
gi 696312154 161 AYTLMRRQAMSRQQKLIQVAEQIIAMSELLG 191
Cdd:COG3707  163 AYRLLRKQAMDRRVKLAEVAEAILAAAELLK 193
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
 2-119 1.80e-12

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 61.28  E-value: 1.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   2 LRILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFTD 81
Cdd:cd19932    1 VRVLIAEDEALIRMDLREMLEEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIAPIVLLTA 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 696312154  82 EHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAMAR 119
Cdd:cd19932   81 YSQQDLVERAKEAGAMAYLVKPFSESDLIPAIEMAIAR 118
ANTAR smart01012
ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found ...
 130-184 9.20e-12

ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; The majority of the domain consists of a coiled-coil.


Pssm-ID: 198080 [Multi-domain]  Cd Length: 55  Bit Score: 57.49  E-value: 9.20e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 696312154   130 LQARDQQLAERKRIELAKGMLMKMKACNEEEAYTLMRRQAMSRQQKLIQVAEQII 184
Cdd:smart01012   1 LEQLREALESRKVIEQAKGILMERRGLSEEEAFELLRKLAMDRNVKLRDVAEAIV 55
ANTAR pfam03861
ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding ...
 137-181 1.58e-11

ANTAR domain; ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.


Pssm-ID: 427550 [Multi-domain]  Cd Length: 46  Bit Score: 56.57  E-value: 1.58e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 696312154  137 LAERKRIELAKGMLMKMKACNEEEAYTLMRRQAMSRQQKLIQVAE 181
Cdd:pfam03861   2 LESRKVIEQAKGILMERLGLSEDEAFRLLRKLSMDRNVKLREVAE 46
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 1-147 1.89e-10

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 57.23  E-value: 1.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   1 MLRILLINDTPRKVGRLRTALIEAGFEVID----ESGLtidlpARVETVRPDVILIDTESP---GRDVMEQVvlvsRDQP 73
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLLEAAGYEVVEaadgEEAL-----ELLQEHRPDLILLDLEMPdmdGLELCRRL----RADP 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154  74 R----PIVMFTDEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAmARFESDQ---ALRAQLQARDQQLAERKRIELA 146
Cdd:COG3706   72 RtadiPIIFLTALDDEEDRARALEAGADDYLTKPFDPEELLARVDLV-ARYGGEEfaiLLPGTDLEGALAVAERIREAVA 150


                 .
gi 696312154 147 K 147
Cdd:COG3706  151 E 151
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
 17-100 1.57e-09

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 53.28  E-value: 1.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154  17 LRTAL-IEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTDEHDPNVMRQAIKS 94
Cdd:cd17535   14 LRRLLeSEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDlKVIVLTAHDDPEYVLRALKA 93


                 ....*.
gi 696312154  95 GVSAYI 100
Cdd:cd17535   94 GAAGYL 99
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 1-129 2.69e-09

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 55.35  E-value: 2.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   1 MLRILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLpARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMF 79
Cdd:COG2204    2 MARILVVDDDPDIRRLLKELLERAGYEVETAASGEEAL-ALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDlPVILL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 696312154  80 TDEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQ 129
Cdd:COG2204   81 TGYGDVETAVEAIKAGAFDYLTKPFDLEELLAAVERALERRRLRRENAED 130
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 1-131 3.86e-09

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 54.02  E-value: 3.86e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   1 MLRILLINDTPRKVGRLRTALIEAGFEVID----ESGLtidlpARVETVRPDVILIDTESPGRD---VMEQVVLVSRDQP 73
Cdd:COG3437    6 APTVLIVDDDPENLELLRQLLRTLGYDVVTaesgEEAL-----ELLLEAPPDLILLDVRMPGMDgfeLLRLLRADPSTRD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 696312154  74 RPIVMFTDEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQLQ 131
Cdd:COG3437   81 IPVIFLTALADPEDRERALEAGADDYLTKPFDPEELLARVRNALELRRLQRELDDLVL 138
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 5-101 1.13e-08

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 50.69  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   5 LLINDTPRKVGRLRTALIEAGFEViDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTDEH 83
Cdd:cd00156    1 LIVDDDPAIRELLKSLLEREGYEV-DTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDiPVIVLTAKA 79

                         90
                 ....*....|....*...
gi 696312154  84 DPNVMRQAIKSGVSAYIV 101
Cdd:cd00156   80 DEEDAVRALELGADDYLV 97
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 1-134 1.80e-07

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 48.04  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   1 MLRILLINDTPRkVGRLRTALIE--AGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIV 77
Cdd:COG4565    3 MIRVLIVEDDPM-VAELLRRYLErlPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDvDVI 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 696312154  78 MFTDEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDvamaRFESDQALRAQLQARD 134
Cdd:COG4565   82 VITAARDPETVREALRAGVVDYLIKPFTFERLREALE----RYLEYRRLLREDQEED 134
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
 3-109 2.52e-07

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 47.27  E-value: 2.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPRP-IVMFTD 81
Cdd:cd17542    2 KVLIVDDAAFMRMMLKDILTKAGYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAkVIMCSA 81

                         90       100
                 ....*....|....*....|....*...
gi 696312154  82 EHDPNVMRQAIKSGVSAYIVEGIQAQRL 109
Cdd:cd17542   82 MGQEEMVKEAIKAGAKDFIVKPFQPERV 109
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 1-122 7.64e-07

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 46.38  E-value: 7.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   1 MLRILLINDTPRKVGRLRTALIEAGFEVID-ESGLtiDLPARVETVRPDVILIDTESP---GRDVMEQVVLVSRDQPRPI 76
Cdd:COG0784    5 GKRILVVDDNPDNRELLRRLLERLGYEVTTaEDGA--EALELLRAGPPDLILLDINMPgmdGLELLRRIRALPRLPDIPI 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 696312154  77 VMFTDEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAMARFES 122
Cdd:COG0784   83 IALTAYADEEDRERALEAGADDYLTKPVDPEELLEALRRLLARASA 128
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
 2-114 7.96e-06

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 43.39  E-value: 7.96e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   2 LRILLINDTPRkVGRLRTALIEA--GFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQV-VLVSRDQPRPIVM 78
Cdd:cd19925    1 INVLIVEDDPM-VAEIHRAYVEQvpGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLrELRAAGHDVDVIV 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 696312154  79 FTDEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILD 114
Cdd:cd19925   80 VTAANDVETVREALRLGVVDYLIKPFTFERLRQRLE 115
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
 3-100 9.73e-06

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 42.81  E-value: 9.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRD---VMEQVVLVSRDQPRPIVMF 79
Cdd:cd17551    2 RILIVDDNPTNLLLLEALLRSAGYLEVVSFTDPREALAWCRENPPDLILLDYMMPGMDgleFIRRLRALPGLEDVPIVMI 81

                         90       100
                 ....*....|....*....|.
gi 696312154  80 TDEHDPNVMRQAIKSGVSAYI 100
Cdd:cd17551   82 TADTDREVRLRALEAGATDFL 102
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 1-101 3.18e-05

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 42.64  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   1 MLRILLINDTPRKVGRLRTALIEAGFEVID----ESGLtidlpARVETVRPDVILIDTESPGRD---VMEQVvlvsRDQP 73
Cdd:COG0745    1 MPRILVVEDDPDIRELLADALEREGYEVDTaadgEEAL-----ELLEEERPDLILLDLMLPGMDgleVCRRL----RARP 71

                         90       100       110
                 ....*....|....*....|....*....|
gi 696312154  74 R--PIVMFTDEHDPNVMRQAIKSGVSAYIV 101
Cdd:COG0745   72 SdiPIIMLTARDDEEDRVRGLEAGADDYLT 101
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
 1-134 1.48e-04

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 40.96  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   1 MLRILLINDTPRKVGRLRTALIE-AGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMF 79
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLEKyPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPIIF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 696312154  80 T---DEHdpnvMRQAIKSGVSAYIVEGIQAQRLQPILDVAMARFESDQALRAQLQARD 134
Cdd:COG3279   81 TtayDEY----ALEAFEVNAVDYLLKPIDEERLAKALEKAKERLEAKAAAEASPEEKD 134
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-140 5.09e-04

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 39.83  E-value: 5.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLpARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTD 81
Cdd:PRK11361   6 RILIVDDEDNVRRMLSTAFALQGFETHCANNGRTAL-HLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRtPVILMTA 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 696312154  82 EHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVAMARfesdQALRAQLQARDQQLAER 140
Cdd:PRK11361  85 YAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQL----QSMKKEIRHLHQALSTS 139
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
 3-101 7.90e-04

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 37.45  E-value: 7.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTPRKVGRLRTAL-IEAGFEVIDE--SGLT-IDLparVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIV 77
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILeWEAGFEVVGEaeNGEEaLEL---LEEHKPDLVITDINMPGMDGLELLEAIRELDPDtKII 77

                         90       100
                 ....*....|....*....|....
gi 696312154  78 MFTDEHDPNVMRQAIKSGVSAYIV 101
Cdd:COG4753   78 ILSGYSDFEYAQEAIKLGADDYLL 101
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 4-109 8.71e-04

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 37.52  E-value: 8.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154    4 ILLINDTPRKVGRLRTALIEAGFEVID-ESGLtiDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTD 81
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEaDDGK--EALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTtPVIILTA 78

                          90       100
                  ....*....|....*....|....*...
gi 696312154   82 EHDPNVMRQAIKSGVSAYIVEGIQAQRL 109
Cdd:pfam00072  79 HGDEDDAVEALEAGADDFLSKPFDPDEL 106
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
 3-117 1.07e-03

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 37.18  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTPRKVGRLRTALIEAGFEVID----ESGLTIdlparVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIV 77
Cdd:cd17555    2 TILVIDDDEVVRESIAAYLEDSGFQVLQaadgRQGLEL-----FRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDtPVI 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 696312154  78 MFTDEhdpNVMR---QAIKSGVSAYIVegiqaqrlQPILDVAM 117
Cdd:cd17555   77 VVSGA---GVMSdavEALRLGAWDYLT--------KPIEDLAV 108
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
 3-109 1.11e-03

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 37.06  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLPArVETVRPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFTDE 82
Cdd:cd17626    2 RILVVDDDAALAEMIGIVLRGEGFDPAFCGDGTQALAA-FREVRPDLVLLDLMLPGIDGIEVCRQIRAESGVPIVMLTAK 80

                         90       100
                 ....*....|....*....|....*..
gi 696312154  83 HDPNVMRQAIKSGVSAYIVEGIQAQRL 109
Cdd:cd17626   81 SDTVDVVLGLESGADDYVAKPFKPKEL 107
PRK10610 PRK10610
chemotaxis protein CheY;
2-114 1.27e-03

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 37.26  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   2 LRILLIND--TPRKVgrLRTALIEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRD---QPRPI 76
Cdd:PRK10610   6 LKFLVVDDfsTMRRI--VRNLLKELGFNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIRADgamSALPV 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 696312154  77 VMFTDEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILD 114
Cdd:PRK10610  84 LMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLN 121
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
 2-116 1.28e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 37.32  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   2 LRILLIND--TPRKVgrLRTALIEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR---PI 76
Cdd:cd19923    1 MKVLVVDDfsTMRRI--IKNLLKELGFNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRADGALshlPV 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 696312154  77 VMFTDEHDPNVMRQAIKSGVSAYIVEGIQAQRLQPILDVA 116
Cdd:cd19923   79 LMVTAEAKKENVIAAAQAGVNNYIVKPFTAATLKEKLEKI 118
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
 17-109 1.31e-03

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 36.87  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154  17 LRTAL-----IEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTDEHDPNVMRQ 90
Cdd:cd19930   10 VRGALaalleLEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDtKVLIVTTFGRPGYFRR 89

                         90
                 ....*....|....*....
gi 696312154  91 AIKSGVSAYIVEGIQAQRL 109
Cdd:cd19930   90 ALAAGVDGYVLKDRPIEEL 108
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
 3-109 1.73e-03

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 36.90  E-value: 1.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTP--RKVgrLRTALIEAGFEVID----ESGLtidlpARVETVRPDVILIDTESPGRDVMEQVVLVsRDQPR-- 74
Cdd:cd17562    2 KILAVDDSAsiRQM--VSFTLRGAGYEVVEaadgRDAL-----SKAQSKKFDLIITDQNMPNMDGIELIKEL-RKLPAyk 73

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 696312154  75 --PIVMFTDEHDPNVMRQAIKSGVSAYIVEGIQAQRL 109
Cdd:cd17562   74 ftPILMLTTESSDEKKQEGKAAGATGWLVKPFDPEQL 110
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
 3-95 2.69e-03

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 35.94  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTPRKVGRLRTALIEAGFEVID-ESGltIDLPARVETVRPDVILIDTESPGRDVMEqVVLVSRDQPR----PIV 77
Cdd:cd17538    1 KILVVDDEPANRELLEALLSAEGYEVLTaDSG--QEALALAEEELPDLILLDVMMPGMDGFE-VCRRLKEDPEtrhiPVI 77

                         90
                 ....*....|....*...
gi 696312154  78 MFTDEHDPNVMRQAIKSG 95
Cdd:cd17538   78 MITALDDREDRIRGLEAG 95
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
 46-101 3.98e-03

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 35.85  E-value: 3.98e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 696312154  46 RPDVILIDTESP---GRDVMEQVvlvsRDQPR----PIVMFT---DEHDpnvMRQAIKSGVSAYIV 101
Cdd:cd17557   52 RPDLILLDLNMPrmdGFEVLREI----KADPDlrriPVVVLTtsdAEED---IERAYELGANSYIV 110
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
 1-63 5.47e-03

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 35.64  E-value: 5.47e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 696312154   1 MLRILLINDTPRKVGRLRTAL-IEAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVME 63
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLeAEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLE 64
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
 3-155 7.68e-03

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 35.77  E-value: 7.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTPRkvgrLRTALI-----EAGFEVIDESGLTIDLPARVETVRPDVILIDTESPGRDVMEQVV-LVSRDQPRPI 76
Cdd:PRK10651   8 TILLIDDHPM----LRTGVKqlismAPDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDkLREKSLSGRI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154  77 VMFT-DEHDPNVMrQAIKSGVSAY---------IVEGIQA---------QRLQPILDVAM-ARFESDQALRAQLQARDQQ 136
Cdd:PRK10651  84 VVFSvSNHEEDVV-TALKRGADGYllkdmepedLLKALQQaaagemvlsEALTPVLAASLrANRATTERDVNQLTPRERD 162

                        170
                 ....*....|....*....
gi 696312154 137 LAERkrieLAKGMLMKMKA 155
Cdd:PRK10651 163 ILKL----IAQGLPNKMIA 177
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 3-80 8.39e-03

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 34.66  E-value: 8.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 696312154   3 RILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLPARVETVrPDVILIDTESPGRDVMEQVVLVSRDQPRPIVMFT 80
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTP-PDLILLDLMLPGTDGLTLCREIRRFSDVPIIMVT 77
fixJ PRK09390
response regulator FixJ; Provisional
 21-142 9.41e-03

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 35.75  E-value: 9.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154  21 LIEAGFEV-IDESGltIDLPARVETVRPDVILIDTESPGRDVMEQVV-LVSRDQPRPIVMFTDEHDPNVMRQAIKSGVSA 98
Cdd:PRK09390  23 LDSAGFEVrLFESA--QAFLDALPGLRFGCVVTDVRMPGIDGIELLRrLKARGSPLPVIVMTGHGDVPLAVEAMKLGAVD 100

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 696312154  99 YIVEGIQAQRLQPILDVAMARFES---DQALRAQLQARDQQLAERKR 142
Cdd:PRK09390 101 FIEKPFEDERLIGAIERALAQAPEaakSEAVAADIRARIASLSERER 147
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 3-139 9.89e-03

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 35.97  E-value: 9.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696312154   3 RILLINDTPRKVGRLRTALIEAGFEVIDESGLTIDLpARVETVRPDVILIDTESPGRDVMEQVVLVSRDQPR-PIVMFTD 81
Cdd:PRK13558   9 GVLFVGDDPEAGPVDCDLDEDGRLDVTQIRDFVAAR-DRVEAGEIDCVVADHEPDGFDGLALLEAVRQTTAVpPVVVVPT 87

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 696312154  82 EHDPNVMRQAIKSGVSAYI-----------VEGIQAQRLQPILDVAMARFESDQALRAQLQARDQQLAE 139
Cdd:PRK13558  88 AGDEAVARRAVDADAAAYVpavsddataaiAERIESAVPEHSRDTEARMPISDLTVESDRRLKERALDE 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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