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Conserved domains on  [gi|696222341|ref|WP_032802811|]
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helix-turn-helix transcriptional regulator [Vibrio sp. HENC-03]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 14398449)

AraC family transcriptional regulator containing a cupin domain as its effector domain and an AraC family helix-turn-helix (HTH) DNA binding domain, controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

CATH:  2.60.120.10
Gene Ontology:  GO:0003700|GO:0006355|GO:0043565
PubMed:  11282467|33837749|9409145|12270809|19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 29-122 1.43e-23

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


:

Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 91.48  E-value: 1.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341  29 LVKTIDMPKGYIDALHQHTWHQVIFPIKGLLQTKTDHYQHLVPHTSALFVPAGIQHESIALSHTTFVGIYLNPKFGTEYE 108
Cdd:cd06124    2 LARAADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAGLP 81

                         90
                 ....*....|....
gi 696222341 109 HQVRTITLTPFLNE 122
Cdd:cd06124   82 AEPCVLAVSPLLRE 95
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
183-265 1.11e-22

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 88.76  E-value: 1.11e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341   183 DWSLKQWGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLL-DEELSIQSIADQVGYQNDSSYIKAFKAYFDVTP 261
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLrDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 696222341   262 QQFR 265
Cdd:smart00342  81 SEYR 84
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 29-122 1.43e-23

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 91.48  E-value: 1.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341  29 LVKTIDMPKGYIDALHQHTWHQVIFPIKGLLQTKTDHYQHLVPHTSALFVPAGIQHESIALSHTTFVGIYLNPKFGTEYE 108
Cdd:cd06124    2 LARAADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAGLP 81

                         90
                 ....*....|....
gi 696222341 109 HQVRTITLTPFLNE 122
Cdd:cd06124   82 AEPCVLAVSPLLRE 95
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
183-265 1.11e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 88.76  E-value: 1.11e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341   183 DWSLKQWGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLL-DEELSIQSIADQVGYQNDSSYIKAFKAYFDVTP 261
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLrDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 696222341   262 QQFR 265
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
35-270 3.14e-21

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 89.84  E-value: 3.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341  35 MPKGYIDALHQHTWHQVIFPIKGLLQTKTDHYQHLVPHTSALFVPAGIQHESIALSHTTFVGIYLNPKFGTEYEHQVRTI 114
Cdd:COG2207   18 LLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 115 TLTPFLNELLQEIRRQCEGFVSDEEVSRLLGVLHDQIMKDNVQTFQLLLPEDRRLKLIFEALTDTPALDW--SLKQWGEK 192
Cdd:COG2207   98 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLllTLEELARE 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 696222341 193 VGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLL-DEELSIQSIADQVGYQNDSSYIKAFKAYFDVTPQQFRVNGRR 270
Cdd:COG2207  178 LGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLaETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRA 256
HTH_18 pfam12833
Helix-turn-helix domain;
189-265 1.55e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 80.33  E-value: 1.55e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 696222341  189 WGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLLDEE--LSIQSIADQVGYQNDSSYIKAFKAYFDVTPQQFR 265
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtgLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 164-265 1.02e-17

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 80.97  E-value: 1.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 164 PEDRRLKLIFEALTDTPALDWSLKQWGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLLDE-ELSIQSIADQVG 242
Cdd:COG4977  207 HRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETtDLSIEEIAAACG 286

                         90       100
                 ....*....|....*....|...
gi 696222341 243 YQNDSSYIKAFKAYFDVTPQQFR 265
Cdd:COG4977  287 FGSASHFRRAFRRRFGVSPSAYR 309
ftrA PRK09393
transcriptional activator FtrA; Provisional
 165-265 6.00e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 61.52  E-value: 6.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 165 EDRRLKLIFEALTDTPALDWSLKQWGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLLDEE-LSIQSIADQVGY 243
Cdd:PRK09393 216 ESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSaLSIDQIAERAGF 295

                         90       100
                 ....*....|....*....|..
gi 696222341 244 QNDSSYIKAFKAYFDVTPQQFR 265
Cdd:PRK09393 296 GSEESLRHHFRRRAATSPAAYR 317
 
Name Accession Description Interval E-value
cupin_NimR-like_N cd06124
AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This ...
 29-122 1.43e-23

AraC/XylS family transcriptional regulators similar to NimR, N-terminal cupin domain; This family contains mostly bacterial proteins containing an AraC/XylS family helix-turn-helix (HTH) DNA-binding domain C-terminal to a cupin domain, and may be possible transcriptional regulators. Included in this family is Escherichia coli HTH-type transcriptional regulator NimR (also called YeaM) that negatively regulates expression of the nimT operon and its own expression. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380379 [Multi-domain]  Cd Length: 95  Bit Score: 91.48  E-value: 1.43e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341  29 LVKTIDMPKGYIDALHQHTWHQVIFPIKGLLQTKTDHYQHLVPHTSALFVPAGIQHESIALSHTTFVGIYLNPKFGTEYE 108
Cdd:cd06124    2 LARAADYPAGHRTPWHSHPWGQLLYASSGVMTVETEDGRWLVPPQRAVWIPAGVEHSVRMLGAVELRSLYIDPEAAAGLP 81

                         90
                 ....*....|....
gi 696222341 109 HQVRTITLTPFLNE 122
Cdd:cd06124   82 AEPCVLAVSPLLRE 95
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
183-265 1.11e-22

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 88.76  E-value: 1.11e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341   183 DWSLKQWGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLL-DEELSIQSIADQVGYQNDSSYIKAFKAYFDVTP 261
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLrDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ....
gi 696222341   262 QQFR 265
Cdd:smart00342  81 SEYR 84
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
35-270 3.14e-21

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 89.84  E-value: 3.14e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341  35 MPKGYIDALHQHTWHQVIFPIKGLLQTKTDHYQHLVPHTSALFVPAGIQHESIALSHTTFVGIYLNPKFGTEYEHQVRTI 114
Cdd:COG2207   18 LLLLLLLLLLILLLLALVLLLLLLALLLLLLLLLGLLGGLLLLLLLLLLLGLLLLLLLLLLGLLLLALLALLLLVGLLLL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 115 TLTPFLNELLQEIRRQCEGFVSDEEVSRLLGVLHDQIMKDNVQTFQLLLPEDRRLKLIFEALTDTPALDW--SLKQWGEK 192
Cdd:COG2207   98 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLllTLEELARE 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 696222341 193 VGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLL-DEELSIQSIADQVGYQNDSSYIKAFKAYFDVTPQQFRVNGRR 270
Cdd:COG2207  178 LGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLaETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEYRKRLRA 256
HTH_18 pfam12833
Helix-turn-helix domain;
189-265 1.55e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 80.33  E-value: 1.55e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 696222341  189 WGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLLDEE--LSIQSIADQVGYQNDSSYIKAFKAYFDVTPQQFR 265
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLLEDtgLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYR 79
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 164-265 1.02e-17

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 80.97  E-value: 1.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 164 PEDRRLKLIFEALTDTPALDWSLKQWGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLLDE-ELSIQSIADQVG 242
Cdd:COG4977  207 HRDPRLARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETtDLSIEEIAAACG 286

                         90       100
                 ....*....|....*....|...
gi 696222341 243 YQNDSSYIKAFKAYFDVTPQQFR 265
Cdd:COG4977  287 FGSASHFRRAFRRRFGVSPSAYR 309
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 174-270 3.97e-12

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 65.46  E-value: 3.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 174 EALTDTPALDWSLKQWGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLLDEELSIQSIADQVGYQNDSSYIKAF 253
Cdd:COG2169   91 RLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGLSVTDAAYAAGFGSLSRFYEAF 170

                         90
                 ....*....|....*..
gi 696222341 254 KAYFDVTPQQFRVNGRR 270
Cdd:COG2169  171 KKLLGMTPSAYRRGGAG 187
ftrA PRK09393
transcriptional activator FtrA; Provisional
 165-265 6.00e-11

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 61.52  E-value: 6.00e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 165 EDRRLKLIFEALTDTPALDWSLKQWGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLLDEE-LSIQSIADQVGY 243
Cdd:PRK09393 216 ESDRLGPLIDWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSaLSIDQIAERAGF 295

                         90       100
                 ....*....|....*....|..
gi 696222341 244 QNDSSYIKAFKAYFDVTPQQFR 265
Cdd:PRK09393 296 GSEESLRHHFRRRAATSPAAYR 317
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
174-271 8.80e-07

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 47.02  E-value: 8.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 174 EALTDTPALDW---------SLKQWGEKVGASERTLSRLFSKEFNTSF-QLWRQQIRLIYSLSLLDEELSIQSIADQVGY 243
Cdd:PRK11511   7 DAITIHSILDWiednlesplSLEKVSERSGYSKWHLQRMFKKETGHSLgQYIRSRKMTEIAQKLKESNEPILYLAERYGF 86

                         90       100
                 ....*....|....*....|....*...
gi 696222341 244 QNDSSYIKAFKAYFDVTPQQFRVNGRRG 271
Cdd:PRK11511  87 ESQQTLTRTFKNYFDVPPHKYRMTNMQG 114
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
2-99 1.25e-06

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 46.00  E-value: 1.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341   2 MPTRQIDsHSGVmtSNEMMAANPHSPALVKtIDMPKGYIDALHQHTWHQVIFPIKGLLQTKTDHYQHLVPHTSALFVPAG 81
Cdd:COG1917    1 MRLAEIA-LTGV--SVRVLADGEDELEVVR-VTFEPGARTPWHSHPGEELIYVLEGEGEVEVGGEEYELKPGDVVFIPPG 76

                         90
                 ....*....|....*...
gi 696222341  82 IQHESIALSHTTFVGIYL 99
Cdd:COG1917   77 VPHAFRNLGDEPAVLLVV 94
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 228-265 6.64e-05

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 39.44  E-value: 6.64e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 696222341  228 LDEELSIQSIADQVGYqnDSSY-IKAFKAYFDVTPQQFR 265
Cdd:pfam00165   5 LSTNLTIADIADELGF--SRSYfSRLFKKYTGVTPSQYR 41
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
162-265 8.04e-05

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 43.35  E-value: 8.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 162 LLPEDRRLKLIFEALTDTPALDWSLKQWGEKVGASERTLSRLFSKEFNTSFQLWRQQIRLIYSLSLL-DEELSIQSIADQ 240
Cdd:PRK13501 171 LLPDGEQLDLIMSALQQSLGAYFDMADFCHKNQLVERSLKQLFRQQTGMSISHYLRQIRLCHAKCLLrGSEHRISDIAAR 250

                         90       100
                 ....*....|....*....|....*.
gi 696222341 241 VGYqNDSSYIKA-FKAYFDVTPQQFR 265
Cdd:PRK13501 251 CGF-EDSNYFSAvFTREAGMTPRDYR 275
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 172-264 3.42e-04

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 41.52  E-value: 3.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 172 IFEALTDTPALDWSLKQWGEKVGASERTLSRLFSKEfNTSFQLWRQQIRLIYSLSLLDE-ELSIQSIADQVGYQNDSSYI 250
Cdd:PRK15185 211 VYNIISSSPSRQWKLTDVADHIFMSTSTLKRKLAEE-GTSFSDIYLSARMNQAAKLLRIgNHNVNAVALKCGYDSTSYFI 289

                         90
                 ....*....|....
gi 696222341 251 KAFKAYFDVTPQQF 264
Cdd:PRK15185 290 QCFKKYFKTTPSTF 303
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 191-265 6.68e-04

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 40.40  E-value: 6.68e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 696222341 191 EKVGASERTLSRLFSKEfNTSFQLWRQQIRLIYSL----SLLDEElSIQSIADQVGYQNDSSYIKAFKAYFDVTPQQFR 265
Cdd:PRK09685 222 GELGISVRSLYRLFAEQ-GLVVAQYIRNRRLDRCAddlrPAADDE-KITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYR 298
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 184-263 8.30e-04

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 40.07  E-value: 8.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 184 WSLKQWGEKVGASERTLSRLFSKEfNTSFQLWRQQIRLIYSLSLLDEELSIQSIADQVGYQNDSSYIKAFKAYFDVTPQQ 263
Cdd:PRK09940 151 WKLKDICDCLYISESLLKKKLKQE-QTTFSQILLDARMQHAKNLIRVEGSVNKIAEQCGYASTSYFIYAFRKHFGNSPKR 229
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 184-264 2.56e-03

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 38.51  E-value: 2.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 696222341 184 WSLKQWGEKVGASERTLSRLFSKEfNTSFQLWRQQIRLIYSLSLL-DEELSIQSIADQVGYQNDSSYIKAFKAYFDVTPQ 262
Cdd:PRK15186 198 WALKDISDSLYMSCSTLKRKLKQE-NTSFSEVYLNARMNKATKLLrNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPS 276


                 ..
gi 696222341 263 QF 264
Cdd:PRK15186 277 EF 278
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 183-217 4.98e-03

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 34.05  E-value: 4.98e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 696222341  183 DWSLKQWGEKVGASERTLSRLFSKEFNTSFQLWRQ 217
Cdd:pfam00165   8 NLTIADIADELGFSRSYFSRLFKKYTGVTPSQYRH 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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