NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|695792229|ref|WP_032706451|]
View 

MULTISPECIES: Lrp/AsnC family transcriptional regulator [Klebsiella]

Protein Classification

Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)

Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination

Gene Ontology:  GO:0043565

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 1.85e-54

DNA-binding transcriptional regulator, Lrp family [Transcription];


:

Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 168.03  E-value: 1.85e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695792229   1 MDSIDRKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYRANLDPGKMGFNFLAIVFATLkegDKKAVS 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV---PPHRLD 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 695792229  81 AFEEAVAEIPQVVLAQRLFGDPDYLMHVVTRDLPAFQKLYDDKLSAMPGVQHLRSTLVM 139
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 1.85e-54

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 168.03  E-value: 1.85e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695792229   1 MDSIDRKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYRANLDPGKMGFNFLAIVFATLkegDKKAVS 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV---PPHRLD 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 695792229  81 AFEEAVAEIPQVVLAQRLFGDPDYLMHVVTRDLPAFQKLYDDKLSAMPGVQHLRSTLVM 139
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
1-110 2.53e-42

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 136.49  E-value: 2.53e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695792229     1 MDSIDRKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYRANLDPGKMGFNFLAIVFATLKEGDKkaVS 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDK--LE 78
                           90       100       110
                   ....*....|....*....|....*....|
gi 695792229    81 AFEEAVAEIPQVVLAQRLFGDPDYLMHVVT 110
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-144 6.30e-31

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 109.08  E-value: 6.30e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695792229   1 MDSIDRKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYRANLDPGKMGFNFLAIVFATLKEGDKKAVS 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695792229  81 AFEEAVAEIPQVVLAQRLFGDPDYLMHVVTRDLPAFQKLYDDKLSAMPGVQHLRSTLVMKTVVQ 144
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQ 155
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
75-141 9.48e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 77.57  E-value: 9.48e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695792229   75 DKKAVSAFEEAVAEIPQVVLAQRLFGDPDYLMHVVTRDLPAFQKLYDDKLSAMPGVQHLRSTLVMKT 141
Cdd:pfam01037   7 PGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
2-52 1.62e-10

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 54.23  E-value: 1.62e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 695792229   2 DSIDRKILAELqADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYRA 52
Cdd:cd00090    6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
7-48 7.49e-04

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 38.11  E-value: 7.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 695792229    7 KILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVIT 48
Cdd:TIGR01884 147 KILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVE 188
 
Name Accession Description Interval E-value
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
1-139 1.85e-54

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 168.03  E-value: 1.85e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695792229   1 MDSIDRKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYRANLDPGKMGFNFLAIVFATLkegDKKAVS 80
Cdd:COG1522    3 LDEIDRRILRLLQEDGRLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYGAVVDPEKLGLGVTAFVEVKV---PPHRLD 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 695792229  81 AFEEAVAEIPQVVLAQRLFGDPDYLMHVVTRDLPAFQKLYDDKLSAMPGVQHLRSTLVM 139
Cdd:COG1522   80 EFAEALAAIPEVLECYLVTGDYDLLLKVVARDMEELERFLLERLAALPGVRRTETSFVL 138
HTH_ASNC smart00344
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ...
1-110 2.53e-42

helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli)


Pssm-ID: 214628 [Multi-domain]  Cd Length: 108  Bit Score: 136.49  E-value: 2.53e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695792229     1 MDSIDRKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYRANLDPGKMGFNFLAIVFATLKEGDKkaVS 80
Cdd:smart00344   1 LDEIDRKILEELQKDARISLAELAKKVGLSPSTVHNRVKRLEEEGVIKGYTAVLNPKKLGLSVTAFVGVTLENPDK--LE 78
                           90       100       110
                   ....*....|....*....|....*....|
gi 695792229    81 AFEEAVAEIPQVVLAQRLFGDPDYLMHVVT 110
Cdd:smart00344  79 EFLEKLEKLPEVEEVYLVTGDYDYLLKVRA 108
PRK11169 PRK11169
leucine-responsive transcriptional regulator Lrp;
1-144 6.30e-31

leucine-responsive transcriptional regulator Lrp;


Pssm-ID: 183009 [Multi-domain]  Cd Length: 164  Bit Score: 109.08  E-value: 6.30e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695792229   1 MDSIDRKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYRANLDPGKMGFNFLAIVFATLKEGDKKAVS 80
Cdd:PRK11169  12 LDRIDRNILNELQKDGRISNVELSKRVGLSPTPCLERVRRLERQGFIQGYTALLNPHYLDASLLVFVEITLNRGAPDVFE 91
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695792229  81 AFEEAVAEIPQVVLAQRLFGDPDYLMHVVTRDLPAFQKLYDDKLSAMPGVQHLRSTLVMKTVVQ 144
Cdd:PRK11169  92 QFNAAVQKLEEIQECHLVSGDFDYLLKTRVPDMSAYRKLLGETLLRLPGVNDTRTYVVMEEVKQ 155
AsnC_trans_reg pfam01037
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ...
75-141 9.48e-20

Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426007  Cd Length: 73  Bit Score: 77.57  E-value: 9.48e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695792229   75 DKKAVSAFEEAVAEIPQVVLAQRLFGDPDYLMHVVTRDLPAFQKLYDDKLSAMPGVQHLRSTLVMKT 141
Cdd:pfam01037   7 PGHALEEFAEALAAIPEVVECYRVTGDYDYLLKVVARDLEALERFLREKLRSLPGVARTETSIVLST 73
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
4-47 9.58e-19

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 74.39  E-value: 9.58e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 695792229    4 IDRKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVI 47
Cdd:pfam13412   2 TDRKILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
HTH_AsnC-type pfam13404
AsnC-type helix-turn-helix domain;
2-42 6.32e-17

AsnC-type helix-turn-helix domain;


Pssm-ID: 433180 [Multi-domain]  Cd Length: 41  Bit Score: 69.71  E-value: 6.32e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 695792229    2 DSIDRKILAELQADGRLSITELAERVNLSLSPCHRRLRALE 42
Cdd:pfam13404   1 DEIDRKILRLLQEDARISFAELAERVGLSESTVLRRIRRLE 41
PRK11179 PRK11179
DNA-binding transcriptional regulator AsnC; Provisional
1-131 3.62e-14

DNA-binding transcriptional regulator AsnC; Provisional


Pssm-ID: 183019 [Multi-domain]  Cd Length: 153  Bit Score: 65.50  E-value: 3.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695792229   1 MDSIDRKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYRANLDPGKMGFN---FLAIVFATLKEGDkK 77
Cdd:PRK11179   7 IDNLDRGILEALMENARTPYAELAKQFGVSPGTIHVRVEKMKQAGIITGTRVDVNPKQLGYDvccFIGIILKSAKDYP-S 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 695792229  78 AVSAFEeavaEIPQVVLAQRLFGDPDYLMHVVTRDLPAFQKLYDDKLSAMPGVQ 131
Cdd:PRK11179  86 ALAKLE----SLDEVVEAYYTTGHYSIFIKVMCRSIDALQHVLINKIQTIDEIQ 135
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
2-52 1.62e-10

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 54.23  E-value: 1.62e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 695792229   2 DSIDRKILAELqADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYRA 52
Cdd:cd00090    6 DPTRLRILRLL-LEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRRE 55
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
1-48 3.99e-05

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 42.04  E-value: 3.99e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 695792229   1 MDSIDR--KILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVIT 48
Cdd:COG1349    1 MLAEERrqKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLR 50
COG3355 COG3355
Predicted transcriptional regulator [Transcription];
5-88 4.25e-05

Predicted transcriptional regulator [Transcription];


Pssm-ID: 442583 [Multi-domain]  Cd Length: 131  Bit Score: 40.72  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695792229   5 DRKILAELQADGR-LSITELAERVNLSLSPCHRRLRALEQEGVITGYRANLDPGkmGFNFL--AIVFATLKEGDKKAVSA 81
Cdd:COG3355   29 DAEVYLILLENGEpLTVEELAEALDRSRSTVYRSLQKLLEAGLVEREKRNLEGG--GYPYVyyAIDPEELKEKLVDDLDE 106

                 ....*..
gi 695792229  82 FEEAVAE 88
Cdd:COG3355  107 WYEKVGE 113
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
1-48 7.30e-05

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 39.49  E-value: 7.30e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 695792229     1 MDSIDR--KILAELQA-DGRLSITELAERVNLSLSPCHRRLRALEQEGVIT 48
Cdd:smart00346   1 IQSLERglAVLRALAEePGGLTLAELAERLGLSKSTAHRLLNTLQELGYVE 51
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
1-51 1.48e-04

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 38.36  E-value: 1.48e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 695792229   1 MDSIDRKILAEL-QADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYR 51
Cdd:COG2512   13 LLEDERRVLELLrENGGRMTQSEIVKETGWSKSKVSRLLSRLEERGLIEKER 64
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
7-51 2.49e-04

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 37.58  E-value: 2.49e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 695792229     7 KILAELqADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYR 51
Cdd:smart00418   1 KILKLL-AEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRR 44
IclR COG1414
DNA-binding transcriptional regulator, IclR family [Transcription];
3-45 2.96e-04

DNA-binding transcriptional regulator, IclR family [Transcription];


Pssm-ID: 441024 [Multi-domain]  Cd Length: 253  Bit Score: 39.42  E-value: 2.96e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 695792229   3 SIDR--KILAEL-QADGRLSITELAERVNLSLSPCHRRLRALEQEG 45
Cdd:COG1414    7 SLERalAILEALaEAGGGLSLSELARRLGLPKSTVHRLLATLEEEG 52
cas_HTH TIGR01884
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ...
7-48 7.49e-04

CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ]


Pssm-ID: 273852 [Multi-domain]  Cd Length: 203  Bit Score: 38.11  E-value: 7.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 695792229    7 KILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVIT 48
Cdd:TIGR01884 147 KILEVLKATGEKSVKNIAKKLGKSLSTISRHLAELEKKGLVE 188
HTH_IclR pfam09339
IclR helix-turn-helix domain;
3-45 1.29e-03

IclR helix-turn-helix domain;


Pssm-ID: 430539 [Multi-domain]  Cd Length: 52  Bit Score: 35.08  E-value: 1.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 695792229    3 SIDR--KILAEL-QADGRLSITELAERVNLSLSPCHRRLRALEQEG 45
Cdd:pfam09339   1 SLDRalAILDALaEAPGPLTLTEIARRTGLPKSTAHRLLQTLVELG 46
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
6-51 1.49e-03

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 36.02  E-value: 1.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 695792229   6 RKILAELqADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYR 51
Cdd:COG0640   23 LRILRLL-AEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRR 67
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
2-48 2.77e-03

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 34.73  E-value: 2.77e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 695792229   2 DSIDRKILA-ELQADGRL-SITELAERVNLSLSPCHRRLRALEQEGVIT 48
Cdd:cd07377    8 DQLREAILSgELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVE 56
COG2345 COG2345
Predicted transcriptional regulator, ArsR family [Transcription];
6-48 5.56e-03

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441914 [Multi-domain]  Cd Length: 217  Bit Score: 35.67  E-value: 5.56e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 695792229   6 RKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVIT 48
Cdd:COG2345   16 RRILELLKRAGPVTAAELAEALGLTPNAVRRHLDALEEEGLVE 58
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
5-51 6.46e-03

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 35.24  E-value: 6.46e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 695792229   5 DRKILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYR 51
Cdd:COG3398   99 PRRILLYLLENPGATNKELAEELGISRSTVSWHLKRLEEDGLVERER 145
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
7-51 9.78e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 32.90  E-value: 9.78e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 695792229    7 KILAELQADGRLSITELAERVNLSLSPCHRRLRALEQEGVITGYR 51
Cdd:pfam01047   7 HILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSR 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH
HHS Vulnerability Disclosure