MULTISPECIES: Lrp/AsnC family transcriptional regulator [Klebsiella]
Lrp/AsnC family transcriptional regulator( domain architecture ID 11445815)
Lrp/AsnC (leucine-responsive regulatory protein/asparagine synthase C) family transcriptional regulator regulates many cellular processes such as amino acid metabolism, pili synthesis, and DNA repair and recombination
List of domain hits
Name | Accession | Description | Interval | E-value | |||
Lrp | COG1522 | DNA-binding transcriptional regulator, Lrp family [Transcription]; |
1-139 | 1.85e-54 | |||
DNA-binding transcriptional regulator, Lrp family [Transcription]; : Pssm-ID: 441131 [Multi-domain] Cd Length: 138 Bit Score: 168.03 E-value: 1.85e-54
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Name | Accession | Description | Interval | E-value | |||
Lrp | COG1522 | DNA-binding transcriptional regulator, Lrp family [Transcription]; |
1-139 | 1.85e-54 | |||
DNA-binding transcriptional regulator, Lrp family [Transcription]; Pssm-ID: 441131 [Multi-domain] Cd Length: 138 Bit Score: 168.03 E-value: 1.85e-54
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HTH_ASNC | smart00344 | helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ... |
1-110 | 2.53e-42 | |||
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli) Pssm-ID: 214628 [Multi-domain] Cd Length: 108 Bit Score: 136.49 E-value: 2.53e-42
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PRK11169 | PRK11169 | leucine-responsive transcriptional regulator Lrp; |
1-144 | 6.30e-31 | |||
leucine-responsive transcriptional regulator Lrp; Pssm-ID: 183009 [Multi-domain] Cd Length: 164 Bit Score: 109.08 E-value: 6.30e-31
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AsnC_trans_reg | pfam01037 | Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ... |
75-141 | 9.48e-20 | |||
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 426007 Cd Length: 73 Bit Score: 77.57 E-value: 9.48e-20
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HTH_ARSR | cd00090 | Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ... |
2-52 | 1.62e-10 | |||
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions. Pssm-ID: 238042 [Multi-domain] Cd Length: 78 Bit Score: 54.23 E-value: 1.62e-10
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cas_HTH | TIGR01884 | CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ... |
7-48 | 7.49e-04 | |||
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ] Pssm-ID: 273852 [Multi-domain] Cd Length: 203 Bit Score: 38.11 E-value: 7.49e-04
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Name | Accession | Description | Interval | E-value | |||
Lrp | COG1522 | DNA-binding transcriptional regulator, Lrp family [Transcription]; |
1-139 | 1.85e-54 | |||
DNA-binding transcriptional regulator, Lrp family [Transcription]; Pssm-ID: 441131 [Multi-domain] Cd Length: 138 Bit Score: 168.03 E-value: 1.85e-54
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HTH_ASNC | smart00344 | helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase ... |
1-110 | 2.53e-42 | |||
helix_turn_helix ASNC type; AsnC: an autogenously regulated activator of asparagine synthetase A transcription in Escherichia coli) Pssm-ID: 214628 [Multi-domain] Cd Length: 108 Bit Score: 136.49 E-value: 2.53e-42
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PRK11169 | PRK11169 | leucine-responsive transcriptional regulator Lrp; |
1-144 | 6.30e-31 | |||
leucine-responsive transcriptional regulator Lrp; Pssm-ID: 183009 [Multi-domain] Cd Length: 164 Bit Score: 109.08 E-value: 6.30e-31
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AsnC_trans_reg | pfam01037 | Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family ... |
75-141 | 9.48e-20 | |||
Lrp/AsnC ligand binding domain; The l-leucine-responsive regulatory protein (Lrp/AsnC) family is a family of similar bacterial transcription regulatory proteins. The family is named after two E. coli proteins involved in regulating amino acid metabolism. This entry corresponds to the usually C-terminal regulatory ligand binding domain. Structurally this domain has a dimeric alpha/beta barrel fold. This domain binds almost exclusively amino acids but also 4-hydroxyphenylpyruvate and kynurenine (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). Pssm-ID: 426007 Cd Length: 73 Bit Score: 77.57 E-value: 9.48e-20
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HTH_24 | pfam13412 | Winged helix-turn-helix DNA-binding; |
4-47 | 9.58e-19 | |||
Winged helix-turn-helix DNA-binding; Pssm-ID: 404317 [Multi-domain] Cd Length: 45 Bit Score: 74.39 E-value: 9.58e-19
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HTH_AsnC-type | pfam13404 | AsnC-type helix-turn-helix domain; |
2-42 | 6.32e-17 | |||
AsnC-type helix-turn-helix domain; Pssm-ID: 433180 [Multi-domain] Cd Length: 41 Bit Score: 69.71 E-value: 6.32e-17
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PRK11179 | PRK11179 | DNA-binding transcriptional regulator AsnC; Provisional |
1-131 | 3.62e-14 | |||
DNA-binding transcriptional regulator AsnC; Provisional Pssm-ID: 183019 [Multi-domain] Cd Length: 153 Bit Score: 65.50 E-value: 3.62e-14
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HTH_ARSR | cd00090 | Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ... |
2-52 | 1.62e-10 | |||
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions. Pssm-ID: 238042 [Multi-domain] Cd Length: 78 Bit Score: 54.23 E-value: 1.62e-10
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GlpR | COG1349 | DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ... |
1-48 | 3.99e-05 | |||
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism]; Pssm-ID: 440960 [Multi-domain] Cd Length: 254 Bit Score: 42.04 E-value: 3.99e-05
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COG3355 | COG3355 | Predicted transcriptional regulator [Transcription]; |
5-88 | 4.25e-05 | |||
Predicted transcriptional regulator [Transcription]; Pssm-ID: 442583 [Multi-domain] Cd Length: 131 Bit Score: 40.72 E-value: 4.25e-05
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HTH_ICLR | smart00346 | helix_turn_helix isocitrate lyase regulation; |
1-48 | 7.30e-05 | |||
helix_turn_helix isocitrate lyase regulation; Pssm-ID: 214629 [Multi-domain] Cd Length: 91 Bit Score: 39.49 E-value: 7.30e-05
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COG2512 | COG2512 | Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ... |
1-51 | 1.48e-04 | |||
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only]; Pssm-ID: 442002 [Multi-domain] Cd Length: 80 Bit Score: 38.36 E-value: 1.48e-04
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HTH_ARSR | smart00418 | helix_turn_helix, Arsenical Resistance Operon Repressor; |
7-51 | 2.49e-04 | |||
helix_turn_helix, Arsenical Resistance Operon Repressor; Pssm-ID: 197713 [Multi-domain] Cd Length: 66 Bit Score: 37.58 E-value: 2.49e-04
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IclR | COG1414 | DNA-binding transcriptional regulator, IclR family [Transcription]; |
3-45 | 2.96e-04 | |||
DNA-binding transcriptional regulator, IclR family [Transcription]; Pssm-ID: 441024 [Multi-domain] Cd Length: 253 Bit Score: 39.42 E-value: 2.96e-04
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cas_HTH | TIGR01884 | CRISPR locus-related DNA-binding protein; Most but not all examples of this family are ... |
7-48 | 7.49e-04 | |||
CRISPR locus-related DNA-binding protein; Most but not all examples of this family are associated with CRISPR loci, a combination of DNA repeats and characteristic proteins encoded near the repeat cluster. The C-terminal region of this protein is homologous to DNA-binding helix-turn-helix domains with predicted transcriptional regulatory activity. [Regulatory functions, DNA interactions, , ] Pssm-ID: 273852 [Multi-domain] Cd Length: 203 Bit Score: 38.11 E-value: 7.49e-04
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HTH_IclR | pfam09339 | IclR helix-turn-helix domain; |
3-45 | 1.29e-03 | |||
IclR helix-turn-helix domain; Pssm-ID: 430539 [Multi-domain] Cd Length: 52 Bit Score: 35.08 E-value: 1.29e-03
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ArsR | COG0640 | DNA-binding transcriptional regulator, ArsR family [Transcription]; |
6-51 | 1.49e-03 | |||
DNA-binding transcriptional regulator, ArsR family [Transcription]; Pssm-ID: 440405 [Multi-domain] Cd Length: 92 Bit Score: 36.02 E-value: 1.49e-03
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WHTH_GntR | cd07377 | Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ... |
2-48 | 2.77e-03 | |||
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences. Pssm-ID: 153418 [Multi-domain] Cd Length: 66 Bit Score: 34.73 E-value: 2.77e-03
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COG2345 | COG2345 | Predicted transcriptional regulator, ArsR family [Transcription]; |
6-48 | 5.56e-03 | |||
Predicted transcriptional regulator, ArsR family [Transcription]; Pssm-ID: 441914 [Multi-domain] Cd Length: 217 Bit Score: 35.67 E-value: 5.56e-03
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COG3398 | COG3398 | Predicted transcriptional regulator, contains two HTH domains [Transcription]; |
5-51 | 6.46e-03 | |||
Predicted transcriptional regulator, contains two HTH domains [Transcription]; Pssm-ID: 442625 [Multi-domain] Cd Length: 159 Bit Score: 35.24 E-value: 6.46e-03
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MarR | pfam01047 | MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ... |
7-51 | 9.78e-03 | |||
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif. Pssm-ID: 426012 [Multi-domain] Cd Length: 59 Bit Score: 32.90 E-value: 9.78e-03
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Blast search parameters | ||||
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